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CXCL3 Gene

protein-coding   GIFtS: 58
GCID: GC04M074891

Chemokine (C-X-C Motif) Ligand 3

(Previous name: GRO3 oncogene)
(Previous symbol: GRO3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chemokine (C-X-C Motif) Ligand 31 2     MIP2B2 5
GRO31 2 3 5     CINC-2b2
GRO3 Oncogene1 2     GROg2
Growth-Regulated Protein Gamma2 3     MIP-2b2
Macrophage Inflammatory Protein 2-Beta2 3     C-X-C Motif Chemokine 32
GRO-gamma2 3     Melanoma Growth Stimulatory Activity Gamma2
GRO-gamma(1-73)2 3     MGSA Gamma2
MIP2-beta2 3     GROG3
SCYB32 3     

External Ids:    HGNC: 46041   Entrez Gene: 29212   Ensembl: ENSG000001637347   OMIM: 1391115   UniProtKB: P198763   
ORGUL members:         

Export aliases for CXCL3 gene to outside databases

Previous GC identifers: GC04M075141 GC04M075302 GC04M075368 GC04M075267 GC04M075121 GC04M070713


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CXCL3 Gene:
CXCL3 (chemokine (C-X-C motif) ligand 3) is a protein-coding gene. Diseases associated with CXCL3 include legionellosis, and ovarian epithelial cancer. GO annotations related to this gene include chemokine activity. An important paralog of this gene is PPBP.

UniProtKB/Swiss-Prot: CXCL3_HUMAN, P19876
Function: Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in
inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form
GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CXCL3 gene promoter:
         Max1   STAT1   STAT4   STAT1beta   HNF-3beta   STAT1alpha   STAT2   ARP-1   STAT3   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXCL3 promoter sequence
   Search Chromatin IP Primers for CXCL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CXCL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q21

CXCL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCL3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M074891:  view genomic region     (about GC identifiers)

Start:
74,902,306 bp from pter      End:
74,904,524 bp from pter
Size:
2,219 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CXCL3_HUMAN, P19876 (See protein sequence)
Recommended Name: C-X-C motif chemokine 3 precursor  
Size: 107 amino acids; 11342 Da
Secondary accessions: Q4W5H9

Explore the universe of human proteins at neXtProt for CXCL3: NX_P19876

Explore proteomics data for CXCL3 at MOPED

Post-translational modifications: 

  • N-terminal processed form GRO-gamma(5-73) is produced by proteolytic cleavage after secretion from peripheral
    blood monocytes1
  • Modification sites at neXtProt

  • See CXCL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002081.2  
    ENSEMBL proteins: 
     ENSP00000296026  
    Reactome Protein details: P19876

    CXCL3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CXCL3 (CXCL3/GRO gamma/CINC-2/DCIP-1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CXCL3
    GenScript Purified and Recombinant Proteins for CXCL3
    Novus Biologicals CXCL3 Proteins
    Sino Biological Recombinant Protein for CXCL3
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CXCL3
    Browse Proteins at Cloud-Clone Corp.

    CXCL3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CXCL3 (CXCL3/GRO gamma/CINC-2/DCIP-1)
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    OriGene Custom Antibody Services for CXCL3
    Novus Biologicals CXCL3 Antibody
    Abcam antibodies for CXCL3
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CXCL3
    LSBio Antibodies in human, mouse, rat for CXCL3

    CXCL3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CXCL3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CXCL3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    3 InterPro protein domains:
     IPR001811 Chemokine_IL8-like_dom
     IPR001089 Chemokine_CXC
     IPR018048 Chemokine_CXC_CS

    Graphical View of Domain Structure for InterPro Entry P19876

    ProtoNet protein and cluster: P19876

    1 Blocks protein domain: IPB002473 Interleukin-8 signature

    UniProtKB/Swiss-Prot: CXCL3_HUMAN, P19876
    Similarity: Belongs to the intercrine alpha (chemokine CxC) family


    CXCL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CXCL3_HUMAN, P19876
    Function: Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in
    inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form
    GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008009chemokine activity ISS--
         
    CXCL3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CXCL3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CXCL3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CXCL3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CXCL3

    miRNA
    Products:
        
    miRTarBase miRNAs that target CXCL3:
    hsa-mir-335-5p (MIRT018278), hsa-mir-1 (MIRT023824), hsa-mir-204-5p (MIRT005823)

    Block miRNA regulation of human, mouse, rat CXCL3 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate CXCL3:
    hsa-miR-3910 hsa-miR-3163 hsa-miR-641 hsa-miR-409-3p hsa-miR-194 hsa-miR-3662 hsa-miR-3617 hsa-miR-888*
    SwitchGear 3'UTR luciferase reporter plasmidCXCL3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CXCL3
    Predesigned siRNA for gene silencing in human, mouse, rat CXCL3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CXCL3

    Clone
    Products:
         
    OriGene clones in human, mouse for CXCL3 (see all 6)
    OriGene ORF clones in mouse, rat for CXCL3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CXCL3 (NM_002090)
    Sino Biological Human cDNA Clone for CXCL3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CXCL3
    Browse ESI BIO Cell Lines and PureStem Progenitors for CXCL3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CXCL3_HUMAN, P19876: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA10095777

    CXCL3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CXCL3 About   (see all 12)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    IL-6 Pathway0.61
    MIF Mediated Glucocorticoid Regulation0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43
    2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine receptors bind chemokines0.81
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    3Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    4Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.44
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CXCL3
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    17 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CXCL3 (see first 5)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    MIF Mediated Glucocorticoid Regulation
    Rho Family GTPases
    Akt Signaling
    PAK Pathway
    MIF Regulation of Innate Immune Cells
    Chemokine Signaling
    STAT3 Pathway
    ERK Signaling
    all-trans-Retinoic Acid Signaling in Brain
    PEDF Induced Signaling
    p38 Signaling
    RAR-Gamma-RXR-Alpha Degradation
    IL-6 Pathway


    2 Reactome Pathways for CXCL3
        Chemokine receptors bind chemokines
    G alpha (i) signalling events


    5 Kegg Pathways  (Kegg details for CXCL3):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    TNF signaling pathway
    Salmonella infection
    Legionellosis


    CXCL3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CXCL3 (see all 10): 
              Angiogenic Growth Factors in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Angiogenesis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Th17 Response in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CXCL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CXCL3 (P198763 ENSP000002960264) via UniProtKB, MINT, STRING, and/or I2D (see all 153)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CXCR2P250253, ENSP000003196354I2D: score=1 STRING: ENSP00000319635
    CXCR1P250243, ENSP000002956834I2D: score=1 STRING: ENSP00000295683
    MMP12P399003I2D: score=1 
    PLSCR1O151623I2D: score=1 
    ACKR3ENSP000002729284STRING: ENSP00000272928
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0030593neutrophil chemotaxis ISS--

    CXCL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CXCL3

    5 Novoseek inferred chemical compound relationships for CXCL3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    grogamma 98.6 18 8702798 (5), 15832427 (2), 9553055 (2), 10695618 (1) (see all 9)
    grobeta 96.5 16 8702798 (5), 15832427 (2), 9553055 (2), 10695618 (1) (see all 7)
    groalpha 92.7 10 8702798 (2), 10695618 (1), 9054580 (1), 19594487 (1) (see all 6)
    rantes 68.4 7 7682242 (2), 15832427 (1), 11001915 (1), 11808935 (1) (see all 6)
    calcium 0 4 10095777 (1), 8340371 (1), 8702798 (1)



    CXCL3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CXCL3 gene: 
    NM_002090.2  

    Unigene Cluster for CXCL3:

    Chemokine (C-X-C motif) ligand 3
    Hs.89690  [show with all ESTs]
    Unigene Representative Sequence: AK311367
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296026(uc003hhl.3) ENST00000511669 ENST00000502974 ENST00000510390

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CXCL3 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate CXCL3:
    hsa-miR-3910 hsa-miR-3163 hsa-miR-641 hsa-miR-409-3p hsa-miR-194 hsa-miR-3662 hsa-miR-3617 hsa-miR-888*
    SwitchGear 3'UTR luciferase reporter plasmidCXCL3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CXCL3
    Predesigned siRNA for gene silencing in human, mouse, rat CXCL3
    Clone
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    OriGene clones in human, mouse for CXCL3 (see all 6)
    OriGene ORF clones in mouse, rat for CXCL3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CXCL3 (NM_002090)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CXCL3
    OriGene qSTAR qPCR primer pairs in human, mouse for CXCL3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CXCL3
      QuantiTect SYBR Green Assays in human, mouse, rat CXCL3
      QuantiFast Probe-based Assays in human, mouse, rat CXCL3

    Additional mRNA sequence: 

    AK307064.1 AK311367.1 BC016308.1 BC065743.1 M36821.1 X53800.1 

    3 DOTS entries:

    DT.105208  DT.40257611  DT.97783873 

    Selected AceView cDNA sequences (see all 34):

    BU626899 X53800 BI832837 AI829424 BC065743 CR591181 CD370075 BM128099 
    CD743042 BM128087 CB129465 BM828712 M36821 CB128389 NM_002090 BG570567 
    CD520079 BX352546 BV192573 BQ215959 BX390861 BC016308 CA309555 T29169 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CXCL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAATAAAAG
    CXCL3 Expression
    About this image


    CXCL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Heart (Cardiovascular System)
             Mature Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Mature Cardiac Fibroblasts Myocardium
     
     Smooth Muscle (Muscoskeletal System)
    CXCL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CXCL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.89690
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CXCL3 (see all 10): 
              Angiogenic Growth Factors in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Angiogenesis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Th17 Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CXCL3
    OriGene qSTAR qPCR primer pairs in human, mouse for CXCL3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CXCL3
    QuantiTect SYBR Green Assays in human, mouse, rat CXCL3
    QuantiFast Probe-based Assays in human, mouse, rat CXCL3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CXCL3 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cxcl35
    Cxcl21
    chemokine (C-X-C motif) ligand 35
    chemokine (C-X-C motif) ligand 21
    78.4(n)1
    69.01(a)1
      5 (44.78 cM)5
    203101  NM_009140.21  NP_033166.11 
     907861035 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    36(a)
    1 → many
    4(50379773-50381069)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    39(a)
    1 → many
    6(60123888-60134622)


    ENSEMBL Gene Tree for CXCL3 (if available)
    TreeFam Gene Tree for CXCL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CXCL3 gene
    PPBP2  PF42  CXCL12  PF4V12  CXCL62  CXCL52  CXCL22  IL82  
    15 SIMAP similar genes for CXCL3 using alignment to 1 protein entry:     CXCL3_HUMAN:
    MGSA gamma    CXCL2    CXCL1    PPBP    CXCL9    CXCL5
    CXCL6    PF4    CXCL10    IL8    PF4V1    CXCL11
    CXCL13    CXCL12    CXCL14

    CXCL3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CXCL3 (see all 177)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs753461951,2
    C--74901871(+) TTTTTA/TATATC 1 -- ds50010--------
    rs1915988241,2
    --74901912(+) ACTTTC/TCTACC 1 -- ds50010--------
    rs1831163441,2
    --74901991(+) TCTAGC/TAGATC 1 -- ds50010--------
    rs1880348751,2
    --74902004(+) GCAGAC/TGCCCA 1 -- ds50010--------
    rs1911604771,2
    --74902126(+) TTGGGA/GGGTAG 1 -- ds50010--------
    rs1129109131,2
    C--74902153(+) GCATCG/AGATAG 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs46946621,2
    C--74902283(+) AAGAAT/GTTTTT 1 -- ds50011Minor allele frequency- G:0.00NA 2
    rs1822829021,2
    --74902380(+) CCAAGA/GGAAAG 1 -- ut310--------
    rs10517541,2
    C--74902527(-) TTTTTA/TAAAAA 1 -- ut310--------
    rs131502581,2
    C,A--74902664(+) TATGGT/CCTCCC 1 -- ut31 ese31Minor allele frequency- C:0.00NA 2

    HapMap Linkage Disequilibrium report for CXCL3 (74902306 - 74904524 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CXCL3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv525980CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CXCL3
    DNA2.0 Custom Variant and Variant Library Synthesis for CXCL3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 139111    OMIM disorders: --

    Selected diseases for CXCL3 (see all 23):    
    About MalaCards
    legionellosis    ovarian epithelial cancer    familial hypercholesterolemia    osteosarcoma
    hypercholesterolemia    ulcerative colitis    bronchiolitis    duchenne muscular dystrophy
    melanoma    cystic fibrosis    periodontitis    muscular dystrophy
    influenza    hepatitis b    tuberculosis    endotheliitis
    inflammatory bowel disease    retinitis    ovarian cancer    hepatitis


    CXCL3 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for CXCL3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon carcinoma 43.3 3 15787094 (1), 20162422 (1)
    necrosis 38.4 2 11001915 (1), 9277410 (1)
    osteosarcoma 37.7 1 18606014 (1)
    inflammation 26.8 1 9553055 (1)
    tumors 23.8 3 10095777 (1), 11001915 (1), 9277410 (1)
    melanoma 16 1 2201751 (1)

    Genetic Association Database (GAD): CXCL3
    Human Genome Epidemiology (HuGE) Navigator: CXCL3 (8 documents)

    Export disorders for CXCL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CXCL3 gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with CXCL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of three related human GRO genes encoding cytokine functions. (PubMed id 2217207)1, 2, 3 Haskill S.... Sager R. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    2. Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms. (PubMed id 10095777)1, 2, 9 Wuyts A.... Van Damme J. (Eur. J. Biochem. 1999)
    3. Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues. (PubMed id 2201751)1, 2, 9 Tekamp-Olson P.... Cerami A. (J. Exp. Med. 1990)
    4. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    5. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    6. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    7. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
    8. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)
    9. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2921 HGNC: 4604 AceView: CXCL3 Ensembl:ENSG00000163734 euGenes: HUgn2921
    ECgene: CXCL3 Kegg: 2921 H-InvDB: CXCL3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CXCL3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CXCL3 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CXCL3

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CXCL3 gene:
    Search GeneIP for patents involving CXCL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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