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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CXCL3 Gene

protein-coding   GIFtS: 55
GCID: GC04M074891

chemokine (C-X-C motif) ligand 3

(Previous name: GRO3 oncogene )
(Previous symbol: GRO3)
 Explore 21 diseases affiliated with
CXCL3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CXCL3    

Aliases
for CXCL3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chemokine (C-X-C Motif) Ligand 31 2     GRO-Gamma1
GRO31 2 3 5     GRO-Gamma(1-73)1
SCYB31 2 3     MIP2-Beta1
CINC-2b1 2     MIP2B2 5
GROg1 2     C-X-C Motif Chemokine 32
MIP-2b1 2     Melanoma Growth Stimulatory Activity Gamma2
GRO3 Oncogene1 2     MGSA Gamma2
Growth-Regulated Protein Gamma2 3     GROG3
Macrophage Inflammatory Protein 2-Beta2 3     

External Ids:    HGNC: 46041   Entrez Gene: 29212   Ensembl: ENSG000001637347   OMIM: 1391115   UniProtKB: P198763   

Export aliases for CXCL3 gene to outside databases

Previous GC identifers: GC04M075141 GC04M075302 GC04M075368 GC04M075267 GC04M075121 GC04M070713


Summaries
for CXCL3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: CXCL3_HUMAN, P19876
Function: Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation
and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows
a fivefold higher chemotactic activity for neutrophilic granulocytes




Genomic Views
for CXCL3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_022778.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CXCL3 gene promoter:
         Max1   STAT1   STAT4   STAT1beta   HNF-3beta   STAT1alpha   STAT2   ARP-1   STAT3   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CXCL3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CXCL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q21

CXCL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCL3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M074891:  view genomic region     (about GC identifiers)

Start:
 74,902,306 bp from pter      End:
 74,904,524 bp from pter
Size:
 2,219 bases      Orientation:
 minus strand

Proteins
for CXCL3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CXCL3_HUMAN, P19876 (See protein sequence)
Recommended Name: C-X-C motif chemokine 3 precursor  
Size: 107 amino acids; 11342 Da
Subcellular location: Secreted
Secondary accessions: Q4W5H9

Explore the universe of human proteins at neXtProt for CXCL3: NX_P19876

Post-translational modifications:

  • N-terminal processed form GRO-gamma(5-73) is produced by proteolytic cleavage after secretion from peripheral blood
    • monocytes1
  • View neXtProt modification sites for NX_P19876

    • CXCL3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002081.2  
    ENSEMBL proteins: 
     ENSP00000296026  
    Reactome Protein details: P19876
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CXCL3 (CXCL3/GRO gamma/CINC-2/DCIP-1)
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for CXCL3 
    GenScript Purified and Recombinant Proteins for CXCL3
    Novus Biologicals CXCL3 Proteins
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CXCL3
    Uscn Proteins for CXCL3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA10095777


    CXCL3 for ontologies           About GeneDecksing



    CXCL3 Antibody Products: 
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    ThermoFisher Antibodies for CXCL3

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    Uscn ELISAs and CLIAs for CXCL3

    Protein Domains /
    Families
    for CXCL3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CXCL3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001811 Chemokine_IL8-like_dom
     IPR001089 Chemokine_CXC
     IPR018048 Chemokine_CXC_CS

    Graphical View of Domain Structure for InterPro Entry P19876

    ProtoNet protein and cluster: P19876

    1 Blocks protein family: IPB002473 Interleukin-8 signature

    UniProtKB/Swiss-Prot: CXCL3_HUMAN, P19876
    Similarity: Belongs to the intercrine alpha (chemokine CxC) family


    Function
    for CXCL3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CXCL3_HUMAN, P19876
    Function: Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation
    and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows
    a fivefold higher chemotactic activity for neutrophilic granulocytes

    miRNA
    Products:            		miRTarBase miRNAs that target CXCL3:
    hsa-mir-204 (MIRT005823)

    OriGene 3'-UTR Clone: CXCL3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCL3
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL3:
    hsa-miR-3910 hsa-miR-3163 hsa-miR-641 hsa-miR-409-3p hsa-miR-194 hsa-miR-3662 hsa-miR-3617 hsa-miR-888*
    SwitchGear 3'UTR luciferase reporter plasmid: CXCL3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXCL3 (see all 4)
    OriGene shRNA RFP: CXCL3
    OriGene siRNA: CXCL3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCL3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CXCL3

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CXCL3 (NM_002090)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CXCL3
    Search LifeMap BioReagents cell lines for CXCL3

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CXCL3

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008009chemokine activity ISS--


    CXCL3 for ontologies           About GeneDecksing



    Pathways & Interactions
    for CXCL3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    8/9 pathways (see all 9)
    		PEDF Induced Signaling1.00
    		RAR-Gamma-RXR-Alpha Degradation0.54
    		MIF Mediated Glucocorticoid Regulation0.73
    		STAT3 Pathway0.47
    		MIF Regulation of Innate Immune Cells0.71
    		Endothelin-1 Signaling Pathway0.44
    		IL-6 Pathway0.61
    		Cytokine-cytokine receptor interaction0.26
    2Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		Peptide ligand-binding receptors0.61
    		GPCR ligand binding0.75
    		G alpha (i) signalling events0.44
    3Rho Family GTPases
    		Rho Family GTPases1.00
    		Molecular Mechanisms of Cancer0.51
    		ERK Signaling0.61
    4Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    5PAK Pathway
    		PAK Pathway1.00
    		Antioxidant Action of Vitamin-C0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CXCL3 (see all 17)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    MIF Mediated Glucocorticoid Regulation

    5/8        Reactome Pathways for CXCL3 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    2         Kegg Pathways  (Kegg details for CXCL3):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway


    CXCL3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CXCL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/153 Interacting proteins for CXCL3 (P198763 ENSP000002960264) via UniProtKB, MINT, STRING, and/or I2D (see all 153)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CXCR2P250253, ENSP000003196354I2D: score=1 STRING: ENSP00000319635
    CXCR1P250243, ENSP000002956834I2D: score=1 STRING: ENSP00000295683
    MMP12P399003I2D: score=1 
    PLSCR1O151623I2D: score=1 
    ANXA1ENSP000002574974STRING: ENSP00000257497
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0030593neutrophil chemotaxis ISS--


    CXCL3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CXCL3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CXCL3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CXCL3
    5 Novoseek chemical compound relationships for CXCL3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    grogamma 98.6 18 8702798 (5), 15832427 (2), 9553055 (2), 10695618 (1) (see all 9)
    grobeta 96.5 16 8702798 (5), 15832427 (2), 9553055 (2), 10695618 (1) (see all 7)
    groalpha 92.7 10 8702798 (2), 10695618 (1), 9054580 (1), 19594487 (1) (see all 6)
    rantes 68.4 7 7682242 (2), 15832427 (1), 11001915 (1), 11808935 (1) (see all 6)
    calcium 0 4 10095777 (1), 8340371 (1), 8702798 (1)

    Search CenterWatch for drugs/clinical trials and news about CXCL3 

    Transcripts
    for CXCL3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CXCL3 gene: 
    NM_002090.2  

    Unigene Cluster for CXCL3:

    Chemokine (C-X-C motif) ligand 3
    Hs.89690  [show with all ESTs]
    Unigene Representative Sequence: AK311367
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296026(uc003hhl.3) ENST00000511669 ENST00000502974 ENST00000510390


    miRNA
    Products:             		 OriGene 3'-UTR Clone: CXCL3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCL3
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL3:
    hsa-miR-3910 hsa-miR-3163 hsa-miR-641 hsa-miR-409-3p hsa-miR-194 hsa-miR-3662 hsa-miR-3617 hsa-miR-888*
    SwitchGear 3'UTR luciferase reporter plasmid: CXCL3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXCL3 (see all 4)
    OriGene shRNA RFP: CXCL3
    OriGene siRNA: CXCL3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCL3
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CXCL3 (NM_002090)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL3 
    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CXCL3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXCL3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL3

    Additional cDNA sequence: 

    AK307064.1 AK311367.1 BC016308.1 BC065743.1 M36821.1 X53800.1 

    3 DOTS entries:

    DT.105208  DT.40257611  DT.97783873 

    24/34 AceView cDNA sequences (see all 34):

    BM128099 CD370075 BI832837 X53800 BM128087 AI829424 BC065743 CR591181 
    CD743042 BU626899 CB129465 BQ215959 CA309305 CB128389 BM828712 BX390861 
    BC016308 CD520079 CA309555 M36821 BX352546 T29169 AW079760 BV192573 

    GeneLoc Exon Structure


    Expression
    for CXCL3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CXCL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATAATAAAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CXCL3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartMyocardiumMature Cardiac FibroblastsEpicardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

    See CXCL3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CXCL3

    SOURCE GeneReport for Unigene cluster: Hs.89690
        SABiosciences Expression via Pathway-Focused PCR Arrays including CXCL3 (see first 5): 
              Angiogenic Growth Factors in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Angiogenesis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Th17 Response in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Antifungal Response in human mouse rat
              Chemokines & Receptors in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL3
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CXCL3

    Orthologs
    for CXCL3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CXCL3 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves --
    		 Uncharacterized protein
    		 36(a)
    		 1 → many
    		 4(52472071-52473367)


    ENSEMBL Gene Tree for CXCL3 (if available)
    TreeFam Gene Tree for CXCL3 (if available) 

    Paralogs
    for CXCL3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CXCL3 gene
    PPBP2  PF42  CXCL12  PF4V12  CXCL62  CXCL52  CXCL22  IL82  
    15 SIMAP similar genes for CXCL3 using alignment to 1 protein entry:     CXCL3_HUMAN:
    MGSA gamma    CXCL2    CXCL1    PPBP    CXCL9    CXCL5
    CXCL6    PF4    CXCL10    IL8    PF4V1    CXCL11
    CXCL13    CXCL12    CXCL14

    CXCL3 for paralogs           About GeneDecksing



    Genomic Variants
    for CXCL3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CXCL3
    DNA2.0 Custom Variant and Variant Library Synthesis for CXCL3

    Disorders / Diseases
    for CXCL3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CXCL3 for disorders           About GeneDecksing

    OMIM gene information: 139111    OMIM disorders: --

    20/21 diseases for CXCL3 (see all 21):    About MalaCards
    melanoma    familial hypercholesterolemia    ulcerative colitis    hypercholesterolemia
    bronchiolitis    cystic fibrosis    colon carcinoma    osteosarcoma
    hepatitis b    fibrosis    colon cancer    periodontitis
    ovarian cancer    influenza    hepatitis    carcinoma
    retinitis    arthritis    tuberculosis    pancreatitis

    6 Novoseek disease relationships for CXCL3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon carcinoma 43.3 3 15787094 (1), 20162422 (1)
    necrosis 38.4 2 11001915 (1), 9277410 (1)
    osteosarcoma 37.7 1 18606014 (1)
    inflammation 26.8 1 9553055 (1)
    tumors 23.8 3 10095777 (1), 11001915 (1), 9277410 (1)
    melanoma 16 1 2201751 (1)

    Human Genome Epidemiology (HuGE) Navigator: CXCL3 (8 documents)

    Export disorders for CXCL3 gene to outside databases

    Publications
    for CXCL3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CXCL3 gene, integrated from 9 sources (see all 57):
    (articles sorted by number of sources associating them with CXCL3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of three related human GRO genes encoding cytokine functions. (PubMed id 2217207)1, 2, 3 Haskill S.... Sager R. (1990)
    2. Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms. (PubMed id 10095777)1, 2, 9 Wuyts A.... Van Damme J. (1999)
    3. Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues. (PubMed id 2201751)1, 2, 9 Tekamp-Olson P.... Cerami A. (1990)
    4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Differential expression of the chemokines GRO-2, GRO- 3, and interleukin-8 in colon cancer and their impact on metastatic disease and survival. (PubMed id 20162422)1, 9 Doll D....Janssen K.P. (2010)
    7. The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor. (PubMed id 8702798)1, 9 Ahuja S.K. and Murphy P.M. (1996)
    8. Constitutive and stimulated MCP-1, GRO alpha, beta, and gamma expression in human airway epithelium and bronchoalveolar macrophages. (PubMed id 8166297)1, 9 Becker S....Haskill J.S. (1994)
    9. Role of IKK and ERK pathways in intrinsic inflammation of cystic fibrosis airways. (PubMed id 17466952)1, 9 Verhaeghe C....Bours V. (2007)
    10. Human hepatocytes express an array of proinflammatory cytokines after agonist stimulation or bacterial invasion. (PubMed id 9277410)1, 9 Rowell D.L....Kagnoff M.F. (1997)

    External Searches for CXCL3 gene

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    Genome Databases showing CXCL3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2921 HGNC: 4604 AceView: CXCL3 Ensembl:ENSG00000163734 euGenes: HUgn2921
    ECgene: CXCL3 Kegg: 2921 H-InvDB: CXCL3

    Other Databases showing CXCL3 gene

    (According to HUGE)
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    Specialized Databases showing CXCL3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CXCL3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CXCL3 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CXCL3

    Intellectual Property
    for CXCL3 gene

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