CXCL3 Gene

Aliases
for CXCL3 gene

Previous GC identifers: GC04M075141 GC04M075302 GC04M075368 GC04M075267 GC04M075121 GC04M070713

Summaries
for CXCL3 gene

Genomic Views
for CXCL3 gene

RefSeq DNA sequence:

NC_000004.11  NC_018915.1  NT_022778.16  

SwitchGear Promoter luciferase reporter plasmid: CXCL3 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCL3

CXCL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M074891:  view genomic region     (about GC identifiers)

Proteins
for CXCL3 gene

Explore the universe of human proteins at neXtProt for CXCL3: NX_P19876

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CXCL3 (CXCL3/GRO gamma/CINC-2/DCIP-1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for CXCL3
	GenScript Purified and Recombinant Proteins for CXCL3
	Novus Biologicals CXCL3 Proteins
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CXCL3
	Uscn Proteins for CXCL3

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CXCL3 (CXCL3/GRO gamma/CINC-2/DCIP-1)
	Browse OriGene Antibodies OriGene Custom Antibody Services for CXCL3
	GenScript Custom Superior Antibodies Services for CXCL3
	Novus Biologicals CXCL3 Antibody
	Search for Antibodies for CXCL3 at Abcam
	Uscn Antibodies for CXCL3
	ThermoFisher Antibodies for CXCL3

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CXCL3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CXCL3

Protein Domains /
Families
for CXCL3 gene

ProtoNet protein and cluster: P19876

Function
for CXCL3 gene

miRNA Products:		miRTarBase miRNAs that target CXCL3: hsa-mir-204 (MIRT005823)
		OriGene 3'-UTR Clone: CXCL3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCL3
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL3:
		hsa-miR-3910 hsa-miR-3163 hsa-miR-641 hsa-miR-409-3p hsa-miR-194 hsa-miR-3662 hsa-miR-3617 hsa-miR-888*
		SwitchGear 3'UTR luciferase reporter plasmid: CXCL3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXCL3 (see all 4) OriGene shRNA RFP: CXCL3 OriGene siRNA: CXCL3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCL3

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CXCL3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL3 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CXCL3 (NM_002090)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CXCL3
		Search LifeMap BioReagents cell lines for CXCL3

In Situ Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CXCL3

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

Pathways & Interactions
for CXCL3 gene

	Super-pathway	contained gene-specific pathways
1	PEDF Induced Signaling	8/9 pathways (see all 9) PEDF Induced Signaling 1.00 RAR-Gamma-RXR-Alpha Degradation 0.54 MIF Mediated Glucocorticoid Regulation 0.73 STAT3 Pathway 0.47 MIF Regulation of Innate Immune Cells 0.71 Endothelin-1 Signaling Pathway 0.44 IL-6 Pathway 0.61 Cytokine-cytokine receptor interaction 0.26
2	Class A/1 (Rhodopsin-like receptors)	Class A/1 (Rhodopsin-like receptors) 1.00 Peptide ligand-binding receptors 0.61 GPCR ligand binding 0.75 G alpha (i) signalling events 0.44
3	Rho Family GTPases	Rho Family GTPases 1.00 Molecular Mechanisms of Cancer 0.51 ERK Signaling 0.61
4	Signaling by GPCR	Signaling by GPCR 1.00 Signal Transduction 0.56 GPCR downstream signaling 0.89
5	PAK Pathway	PAK Pathway 1.00 Antioxidant Action of Vitamin-C 0.56

5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CXCL3

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	Transendothelial Migration of Leukocytes
	MIF Mediated Glucocorticoid Regulation

5/8        Reactome Pathways for CXCL3

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Chemokine receptors bind chemokines
	Signal Transduction
	Signaling by GPCR

2         Kegg Pathways  (Kegg details for CXCL3)

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for CXCL3 gene

Transcripts
for CXCL3 gene

Expression
for CXCL3 gene

CXCL3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATAATAAAAG

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	HeartMyocardiumMature Cardiac Fibroblasts			Epicardium
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CXCL3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CXCL3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXCL3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL3

In Situ Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CXCL3

Orthologs
for CXCL3 gene

Paralogs
for CXCL3 gene

Paralogs for CXCL3 gene

PPBP²  PF4²  CXCL1²  PF4V1²  CXCL6²  CXCL5²  CXCL2²  IL8²  

15 SIMAP similar genes for CXCL3 using alignment to 1 protein entry:     CXCL3_HUMAN:

MGSA gamma    CXCL2    CXCL1    PPBP    CXCL9    CXCL5

CXCL6    PF4    CXCL10    IL8    PF4V1    CXCL11

CXCL13    CXCL12    CXCL14

CXCL3 for paralogs           About GeneDecksing

Genomic Variants
for CXCL3 gene

Disorders / Diseases
for CXCL3 gene

20/21 diseases for CXCL3

6 Novoseek disease relationships for CXCL3 gene    About this table

Publications
for CXCL3 gene

PubMed articles for CXCL3 gene, integrated from 9 sources (see all 57): (articles sorted by number of sources associating them with CXCL3)

Utopia: connect your pdf to the dynamic world of online information

1. Identification of three related human GRO genes encoding cytokine functions. (PubMed id 2217207)^{1, 2, 3} Haskill S.... Sager R. (1990)
2. Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms. (PubMed id 10095777)^{1, 2, 9} Wuyts A.... Van Damme J. (1999)
3. Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues. (PubMed id 2201751)^{1, 2, 9} Tekamp-Olson P.... Cerami A. (1990)
4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
6. Differential expression of the chemokines GRO-2, GRO- 3, and interleukin-8 in colon cancer and their impact on metastatic disease and survival. (PubMed id 20162422)^{1, 9} Doll D....Janssen K.P. (2010)
7. The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor. (PubMed id 8702798)^{1, 9} Ahuja S.K. and Murphy P.M. (1996)
8. Constitutive and stimulated MCP-1, GRO alpha, beta, and gamma expression in human airway epithelium and bronchoalveolar macrophages. (PubMed id 8166297)^{1, 9} Becker S....Haskill J.S. (1994)
9. Role of IKK and ERK pathways in intrinsic inflammation of cystic fibrosis airways. (PubMed id 17466952)^{1, 9} Verhaeghe C....Bours V. (2007)
10. Human hepatocytes express an array of proinflammatory cytokines after agonist stimulation or bacterial invasion. (PubMed id 9277410)^{1, 9} Rowell D.L....Kagnoff M.F. (1997)

External Searches for CXCL3 gene

Genome Databases showing CXCL3 gene

Other Databases showing CXCL3 gene

Specialized Databases showing CXCL3 gene

Products
for CXCL3 gene