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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CXCL3 Gene

protein-coding GIFtS: 55
GCID: GC04M074891

chemokine (C-X-C motif) ligand 3

(Previous name: GRO3 oncogene )
(Previous symbol: GRO3)

Explore 21 diseases affiliated with
CXCL3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chemokine (C-X-C Motif) Ligand 3¹ ²		GRO-Gamma¹
GRO3¹ ² ³ ⁵		GRO-Gamma(1-73)¹
SCYB3¹ ² ³		MIP2-Beta¹
CINC-2b¹ ²		MIP2B² ⁵
GROg¹ ²		C-X-C Motif Chemokine 3²
MIP-2b¹ ²		Melanoma Growth Stimulatory Activity Gamma²
GRO3 Oncogene¹ ²		MGSA Gamma²
Growth-Regulated Protein Gamma² ³		GROG³
Macrophage Inflammatory Protein 2-Beta² ³

External Ids:	HGNC: 4604¹	Entrez Gene: 2921²	Ensembl: ENSG00000163734⁷	OMIM: 139111⁵	UniProtKB: P19876³

Export aliases for CXCL3 gene to outside databases

Previous GC identifers: GC04M075141 GC04M075302 GC04M075368 GC04M075267 GC04M075121 GC04M070713

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CXCL3_HUMAN, P19876

Function: Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation

and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows

a fivefold higher chemotactic activity for neutrophilic granulocytes

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_022778.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CXCL3 gene promoter:
Max1 STAT1 STAT4 STAT1beta HNF-3beta STAT1alpha STAT2 ARP-1 STAT3 Ik-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CXCL3 promoter sequence

Search SABiosciences Chromatin IP Primers for CXCL3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCL3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21 Ensembl cytogenetic band: 4q13.3 HGNC cytogenetic band: 4q21

CXCL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCL3 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M074891: view genomic region (about GC identifiers)

Start:	74,902,306 bp from pter	End:	74,904,524 bp from pter
Size:	2,219 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CXCL3_HUMAN, P19876 (See protein sequence)

Recommended Name: C-X-C motif chemokine 3 precursor

Size: 107 amino acids; 11342 Da

Subcellular location: Secreted

Secondary accessions: Q4W5H9

Explore the universe of human proteins at neXtProt for CXCL3: NX_P19876

Post-translational modifications:

N-terminal processed form GRO-gamma(5-73) is produced by proteolytic cleavage after secretion from peripheral blood

monocytes¹

View neXtProt modification sites for NX_P19876

CXCL3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002081.2

ENSEMBL proteins:

ENSP00000296026

Reactome Protein details: P19876
Human Recombinant Protein Products for CXCL3:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CXCL3 (CXCL3/GRO gamma/CINC-2/DCIP-1)
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	GenScript Purified and Recombinant Proteins for CXCL3
	Novus Biologicals CXCL3 Proteins
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CXCL3
	Uscn Proteins for CXCL3

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IDA	10095777

CXCL3 for ontologies About GeneDecksing

CXCL3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CXCL3 (CXCL3/GRO gamma/CINC-2/DCIP-1)
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	Abcam antibodies for CXCL3
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	ThermoFisher Antibodies for CXCL3

Assay Products for CXCL3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CXCL3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CXCL3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CXCL3 for domains About GeneDecksing

3 InterPro domains/families:

IPR001811 Chemokine_IL8-like_dom

IPR001089 Chemokine_CXC

IPR018048 Chemokine_CXC_CS

Graphical View of Domain Structure for InterPro Entry P19876

ProtoNet protein and cluster: P19876

1 Blocks protein family: IPB002473 Interleukin-8 signature

UniProtKB/Swiss-Prot: CXCL3_HUMAN, P19876

Similarity: Belongs to the intercrine alpha (chemokine CxC) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CXCL3_HUMAN, P19876

Function: Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation

and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows

a fivefold higher chemotactic activity for neutrophilic granulocytes

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008009	chemokine activity	ISS	--

CXCL3 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CXCL3

miRNA Products:		miRTarBase miRNAs that target CXCL3: hsa-mir-204 (MIRT005823)

		OriGene 3'-UTR Clone: CXCL3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCL3
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL3:
		hsa-miR-3910 hsa-miR-3163 hsa-miR-641 hsa-miR-409-3p hsa-miR-194 hsa-miR-3662 hsa-miR-3617 hsa-miR-888*

		SwitchGear 3'UTR luciferase reporter plasmid: CXCL3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXCL3 (see all 4) OriGene shRNA RFP: CXCL3 OriGene siRNA: CXCL3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCL3
		Sirion Biotech Custom design and validation of potent shRNA sequences against CXCL3

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CXCL3
			Sirion Biotech Customized adenovirus for overexpression of CXCL3 Sirion Biotech Customized adenovirus for potent knockdown of CXCL3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CXCL3 (NM_002090)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CXCL3
		Search LifeMap BioReagents cell lines for CXCL3
		Sirion Biotech Customized stable knockdown cell line services for CXCL3 Sirion Biotech Customized inducible knockdown cell line services for CXCL3 Sirion Biotech Customized stable overexpressing cell line services for CXCL3 Sirion Biotech Customized inducible overexpressing cell line services for CXCL3

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CXCL3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PEDF Induced Signaling

8/9 pathways (see all 9)
PEDF Induced Signaling	1.00	RAR-Gamma-RXR-Alpha Degradation	0.54
MIF Mediated Glucocorticoid Regulation	0.73	STAT3 Pathway	0.47
MIF Regulation of Innate Immune Cells	0.71	Endothelin-1 Signaling Pathway	0.44
IL-6 Pathway	0.61	Cytokine-cytokine receptor interaction	0.26

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			Peptide ligand-binding receptors	0.61
	GPCR ligand binding	0.75			G alpha (i) signalling events	0.44

Rho Family GTPases

	Rho Family GTPases	1.00			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

PAK Pathway

PAK Pathway

1.00

Antioxidant Action of Vitamin-C

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CXCL3 (see all 17)

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	Transendothelial Migration of Leukocytes
	MIF Mediated Glucocorticoid Regulation

5/8 Reactome Pathways for CXCL3 (see all 8)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Chemokine receptors bind chemokines
	Signal Transduction
	Signaling by GPCR

2 Kegg Pathways (Kegg details for CXCL3):

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway

CXCL3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CXCL3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

131/153 Interacting proteins for CXCL3 (P19876³ ENSP00000296026⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 153) (see top 5)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CXCR2	P25025³, ENSP00000319635⁴	I2D: score=1 STRING: ENSP00000319635
CXCR1	P25024³, ENSP00000295683⁴	I2D: score=1 STRING: ENSP00000295683
MMP12	P39900³	I2D: score=1
PLSCR1	O15162³	I2D: score=1
ANXA1	ENSP00000257497⁴	STRING: ENSP00000257497
C3	ENSP00000245907⁴	STRING: ENSP00000245907
C3AR1	ENSP00000302079⁴	STRING: ENSP00000302079
C5AR1	ENSP00000347197⁴	STRING: ENSP00000347197
CCL16	ENSP00000293275⁴	STRING: ENSP00000293275
CCL19	ENSP00000308815⁴	STRING: ENSP00000308815
CCL20	ENSP00000351671⁴	STRING: ENSP00000351671
CCL21	ENSP00000259607⁴	STRING: ENSP00000259607
CCL25	ENSP00000375086⁴	STRING: ENSP00000375086
CCL27	ENSP00000259631⁴	STRING: ENSP00000259631
CCL28	ENSP00000354416⁴	STRING: ENSP00000354416
CCL5	ENSP00000293272⁴	STRING: ENSP00000293272
CCR1	ENSP00000296140⁴	STRING: ENSP00000296140
CCR3	ENSP00000350003⁴	STRING: ENSP00000350003
CCR5	ENSP00000292303⁴	STRING: ENSP00000292303
CCR6	ENSP00000339393⁴	STRING: ENSP00000339393
CCR7	ENSP00000246657⁴	STRING: ENSP00000246657
CCR8	ENSP00000326432⁴	STRING: ENSP00000326432
CXCL1	ENSP00000379110⁴	STRING: ENSP00000379110
CXCL10	ENSP00000305651⁴	STRING: ENSP00000305651
CXCL11	ENSP00000306884⁴	STRING: ENSP00000306884
CXCL13	ENSP00000286758⁴	STRING: ENSP00000286758
CXCL16	ENSP00000293778⁴	STRING: ENSP00000293778
CXCL5	ENSP00000296027⁴	STRING: ENSP00000296027
CXCL6	ENSP00000226317⁴	STRING: ENSP00000226317
CXCL9	ENSP00000354901⁴	STRING: ENSP00000354901
CXCR5	ENSP00000292174⁴	STRING: ENSP00000292174
CXCR6	ENSP00000304414⁴	STRING: ENSP00000304414
CXCR7	ENSP00000272928⁴	STRING: ENSP00000272928
FPR1	ENSP00000302707⁴	STRING: ENSP00000302707
GPR18	ENSP00000343428⁴	STRING: ENSP00000343428
HCAR2	ENSP00000375066⁴	STRING: ENSP00000375066
PPBP	ENSP00000296028⁴	STRING: ENSP00000296028
RGS1	ENSP00000356429⁴	STRING: ENSP00000356429
ADCY1	ENSP00000297323⁴	STRING: ENSP00000297323
ADCY2	ENSP00000342952⁴	STRING: ENSP00000342952
ADCY4	ENSP00000312126⁴	STRING: ENSP00000312126
ADCY5	ENSP00000419361⁴	STRING: ENSP00000419361
ADCY6	ENSP00000311405⁴	STRING: ENSP00000311405
ADCY7	ENSP00000254235⁴	STRING: ENSP00000254235
ADCY8	ENSP00000286355⁴	STRING: ENSP00000286355
ADCY9	ENSP00000294016⁴	STRING: ENSP00000294016
ADORA1	ENSP00000308549⁴	STRING: ENSP00000308549
ADORA3	ENSP00000358730⁴	STRING: ENSP00000358730
ADRA2A	ENSP00000280155⁴	STRING: ENSP00000280155
ADRA2B	ENSP00000387281⁴	STRING: ENSP00000387281
ADRA2C	ENSP00000386069⁴	STRING: ENSP00000386069
AGTR2	ENSP00000360973⁴	STRING: ENSP00000360973
APLN	ENSP00000305464⁴	STRING: ENSP00000305464
APLNR	ENSP00000257254⁴	STRING: ENSP00000257254
APP	ENSP00000284981⁴	STRING: ENSP00000284981
BDKRB1	ENSP00000216629⁴	STRING: ENSP00000216629
BDKRB2	ENSP00000307713⁴	STRING: ENSP00000307713
C5	ENSP00000223642⁴	STRING: ENSP00000223642
CASR	ENSP00000296154⁴	STRING: ENSP00000296154
CHRM2	ENSP00000319984⁴	STRING: ENSP00000319984
CHRM4	ENSP00000409378⁴	STRING: ENSP00000409378
DRD2	ENSP00000354859⁴	STRING: ENSP00000354859
DRD3	ENSP00000373169⁴	STRING: ENSP00000373169
DRD4	ENSP00000176183⁴	STRING: ENSP00000176183
FPR2	ENSP00000340191⁴	STRING: ENSP00000340191
FPR3	ENSP00000341821⁴	STRING: ENSP00000341821
GAL	ENSP00000265643⁴	STRING: ENSP00000265643
GALR1	ENSP00000299727⁴	STRING: ENSP00000299727
GALR2	ENSP00000329684⁴	STRING: ENSP00000329684
GALR3	ENSP00000249041⁴	STRING: ENSP00000249041
GNAI2	ENSP00000312999⁴	STRING: ENSP00000312999
GNG2	ENSP00000334448⁴	STRING: ENSP00000334448
GPER	ENSP00000297469⁴	STRING: ENSP00000297469
GPR17	ENSP00000272644⁴	STRING: ENSP00000272644
GPR55	ENSP00000375893⁴	STRING: ENSP00000375893
HEBP1	ENSP00000014930⁴	STRING: ENSP00000014930
HRH3	ENSP00000342560⁴	STRING: ENSP00000342560
HRH4	ENSP00000256906⁴	STRING: ENSP00000256906
HTR1A	ENSP00000316244⁴	STRING: ENSP00000316244
HTR1B	ENSP00000358963⁴	STRING: ENSP00000358963
HTR1D	ENSP00000313661⁴	STRING: ENSP00000313661
HTR1E	ENSP00000307766⁴	STRING: ENSP00000307766
HTR1F	ENSP00000322924⁴	STRING: ENSP00000322924
HTR5A	ENSP00000287907⁴	STRING: ENSP00000287907
KNG1	ENSP00000265023⁴	STRING: ENSP00000265023
LPAR1	ENSP00000351755⁴	STRING: ENSP00000351755
LPAR2	ENSP00000384665⁴	STRING: ENSP00000384665
LPAR3	ENSP00000359643⁴	STRING: ENSP00000359643
MCHR1	ENSP00000249016⁴	STRING: ENSP00000249016
MCHR2	ENSP00000281806⁴	STRING: ENSP00000281806
MTNR1A	ENSP00000302811⁴	STRING: ENSP00000302811
MTNR1B	ENSP00000257068⁴	STRING: ENSP00000257068
NMS	ENSP00000366061⁴	STRING: ENSP00000366061
NMU	ENSP00000264218⁴	STRING: ENSP00000264218
NMUR1	ENSP00000305877⁴	STRING: ENSP00000305877
NMUR2	ENSP00000255262⁴	STRING: ENSP00000255262
NPB	ENSP00000332766⁴	STRING: ENSP00000332766
NPBWR1	ENSP00000330284⁴	STRING: ENSP00000330284
NPBWR2	ENSP00000358783⁴	STRING: ENSP00000358783
NPW	ENSP00000330070⁴	STRING: ENSP00000330070
NPY	ENSP00000242152⁴	STRING: ENSP00000242152
NPY1R	ENSP00000354652⁴	STRING: ENSP00000354652
NPY2R	ENSP00000332591⁴	STRING: ENSP00000332591
NPY5R	ENSP00000339377⁴	STRING: ENSP00000339377
OPRD1	ENSP00000234961⁴	STRING: ENSP00000234961
OPRK1	ENSP00000265572⁴	STRING: ENSP00000265572
OPRL1	ENSP00000336764⁴	STRING: ENSP00000336764
OPRM1	ENSP00000394624⁴	STRING: ENSP00000394624
OXER1	ENSP00000367930⁴	STRING: ENSP00000367930
P2RY12	ENSP00000307259⁴	STRING: ENSP00000307259
P2RY13	ENSP00000320376⁴	STRING: ENSP00000320376
P2RY14	ENSP00000308361⁴	STRING: ENSP00000308361
P2RY4	ENSP00000363643⁴	STRING: ENSP00000363643
PDYN	ENSP00000217305⁴	STRING: ENSP00000217305
PENK	ENSP00000324248⁴	STRING: ENSP00000324248
PMCH	ENSP00000332225⁴	STRING: ENSP00000332225
PNOC	ENSP00000301908⁴	STRING: ENSP00000301908
POMC	ENSP00000264708⁴	STRING: ENSP00000264708
PPY	ENSP00000225992⁴	STRING: ENSP00000225992
PPYR1	ENSP00000363431⁴	STRING: ENSP00000363431
PTGDR2	ENSP00000332812⁴	STRING: ENSP00000332812
PTGER3	ENSP00000349003⁴	STRING: ENSP00000349003
PYY	ENSP00000353198⁴	STRING: ENSP00000353198
RGS10	ENSP00000358099⁴	STRING: ENSP00000358099
RGS14	ENSP00000386229⁴	STRING: ENSP00000386229
RGS18	ENSP00000356430⁴	STRING: ENSP00000356430
RGS19	ENSP00000333194⁴	STRING: ENSP00000333194
RGS20	ENSP00000297313⁴	STRING: ENSP00000297313
RGS4	ENSP00000397181⁴	STRING: ENSP00000397181
RGS6	ENSP00000383953⁴	STRING: ENSP00000383953
RGS7	ENSP00000355520⁴	STRING: ENSP00000355520

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006954	inflammatory response	IEA	--
GO:0006955	immune response	IEA	--
GO:0030593	neutrophil chemotaxis	ISS	--

CXCL3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CXCL3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CXCL3
5 Novoseek chemical compound relationships for CXCL3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
grogamma	98.6	18	8702798 (5), 15832427 (2), 9553055 (2), 10695618 (1) (see all 9)
grobeta	96.5	16	8702798 (5), 15832427 (2), 9553055 (2), 10695618 (1) (see all 7)
groalpha	92.7	10	8702798 (2), 10695618 (1), 9054580 (1), 19594487 (1) (see all 6)
rantes	68.4	7	7682242 (2), 15832427 (1), 11001915 (1), 11808935 (1) (see all 6)
calcium	0	4	10095777 (1), 8340371 (1), 8702798 (1)

Search CenterWatch for drugs/clinical trials and news about CXCL3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CXCL3 gene:

NM_002090.2

Unigene Cluster for CXCL3:

Chemokine (C-X-C motif) ligand 3

Hs.89690 [show with all ESTs]

Unigene Representative Sequence: AK311367

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000296026(uc003hhl.3) ENST00000511669 ENST00000502974 ENST00000510390

miRNA Products:		OriGene 3'-UTR Clone: CXCL3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCL3
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL3:
		hsa-miR-3910 hsa-miR-3163 hsa-miR-641 hsa-miR-409-3p hsa-miR-194 hsa-miR-3662 hsa-miR-3617 hsa-miR-888*

		SwitchGear 3'UTR luciferase reporter plasmid: CXCL3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXCL3 (see all 4) OriGene shRNA RFP: CXCL3 OriGene siRNA: CXCL3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCL3
		Sirion Biotech Custom design and validation of potent shRNA sequences against CXCL3

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Additional cDNA sequence:

AK307064.1 AK311367.1 BC016308.1 BC065743.1 M36821.1 X53800.1

3 DOTS entries:

DT.105208 DT.40257611 DT.97783873

24/34 AceView cDNA sequences (see all 34):

BM128099 CD370075 BI832837 X53800 BM128087 AI829424 BC065743 CR591181

CD743042 BU626899 CB129465 BQ215959 CA309305 CB128389 BM828712 BX390861

BC016308 CD520079 CA309555 M36821 BX352546 T29169 AW079760 BV192573

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CXCL3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATAATAAAAG

About this image

CXCL3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Myocardium

Mature Cardiac Fibroblasts

Epicardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

See CXCL3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CXCL3

SOURCE GeneReport for Unigene cluster: Hs.89690

SABiosciences Expression via Pathway-Focused PCR Arrays including CXCL3 (see all 10):

Angiogenic Growth Factors in human mouse rat

Inflammatory Response & Autoimmunity in human mouse rat

Angiogenesis in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Th17 Response in human mouse rat

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In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CXCL3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CXCL3 gene from 1/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	--	Uncharacterized protein	36(a)	1 → many	4(52472071-52473367)

ENSEMBL Gene Tree for CXCL3 (if available)
TreeFam Gene Tree for CXCL3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CXCL3 gene

PPBP² PF4² CXCL1² PF4V1² CXCL6² CXCL5² CXCL2² IL8²

15 SIMAP similar genes for CXCL3 using alignment to 1 protein entry: CXCL3_HUMAN:

MGSA gamma CXCL2 CXCL1 PPBP CXCL9 CXCL5

CXCL6 PF4 CXCL10 IL8 PF4V1 CXCL11

CXCL13 CXCL12 CXCL14

CXCL3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs35370169^1,2	C	--	74901862(+)	`GGTCAT/-TTTTT`	1	--	ds500¹		1		CSA	2
rs33952565^1,2	C	--	74901863(+)	`TTTTTT/-AATAT`	1	--	ds500¹		1		NA	2
rs75346195^1,2	C	--	74901871(+)	`TTTTTA/TATATC`	1	--	ds500¹		0	--	--	--	--
rs191598824^1,2		--	74901912(+)	`ACTTTC/TCTACC`	1	--	ds500¹		0	--	--	--	--
rs183116344^1,2		--	74901991(+)	`TCTAGC/TAGATC`	1	--	ds500¹		0	--	--	--	--
rs188034875^1,2		--	74902004(+)	`GCAGAC/TGCCCA`	1	--	ds500¹		0	--	--	--	--
rs191160477^1,2		--	74902126(+)	`TTGGGA/GGGTAG`	1	--	ds500¹		0	--	--	--	--
rs4694662^1,2	C	--	74902283(+)	`AAGAAT/GTTTTT`	1	--	ds500¹		1		NA	2
rs182282902^1,2		--	74902380(+)	`CCAAGA/GGAAAG`	1	--	ut3¹		0	--	--	--	--
rs1051754^1,2	C	--	74902527(-)	`TTTTTA/TAAAAA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CXCL3 (74902306 - 74904524 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CXCL3: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CXCL3

DNA2.0 Custom Variant and Variant Library Synthesis for CXCL3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CXCL3 for disorders           About GeneDecksing

OMIM gene information: 139111    OMIM disorders: --

20/21 diseases for CXCL3 (see all 21):    About MalaCards

melanoma familial hypercholesterolemia ulcerative colitis hypercholesterolemia

bronchiolitis cystic fibrosis colon carcinoma osteosarcoma

hepatitis b fibrosis colon cancer periodontitis

ovarian cancer influenza hepatitis carcinoma

retinitis arthritis tuberculosis pancreatitis

6 Novoseek disease relationships for CXCL3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
colon carcinoma	43.3	3	15787094 (1), 20162422 (1)
necrosis	38.4	2	11001915 (1), 9277410 (1)
osteosarcoma	37.7	1	18606014 (1)
inflammation	26.8	1	9553055 (1)
tumors	23.8	3	10095777 (1), 11001915 (1), 9277410 (1)
melanoma	16	1	2201751 (1)

Human Genome Epidemiology (HuGE) Navigator: CXCL3 (8 documents)

Export disorders for CXCL3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CXCL3 gene, integrated from 9 sources (see all 57):
(articles sorted by number of sources associating them with CXCL3)

Utopia: connect your pdf to the dynamic
world of online information

Identification of three related human GRO genes encoding cytokine functions. (PubMed id 2217207)^{1, 2, 3} Haskill S.... Sager R. (1990)
Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms. (PubMed id 10095777)^{1, 2, 9} Wuyts A.... Van Damme J. (1999)
Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues. (PubMed id 2201751)^{1, 2, 9} Tekamp-Olson P.... Cerami A. (1990)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Differential expression of the chemokines GRO-2, GRO- 3, and interleukin-8 in colon cancer and their impact on metastatic disease and survival. (PubMed id 20162422)^{1, 9} Doll D....Janssen K.P. (2010)
The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor. (PubMed id 8702798)^{1, 9} Ahuja S.K. and Murphy P.M. (1996)
Constitutive and stimulated MCP-1, GRO alpha, beta, and gamma expression in human airway epithelium and bronchoalveolar macrophages. (PubMed id 8166297)^{1, 9} Becker S....Haskill J.S. (1994)
Role of IKK and ERK pathways in intrinsic inflammation of cystic fibrosis airways. (PubMed id 17466952)^{1, 9} Verhaeghe C....Bours V. (2007)
Human hepatocytes express an array of proinflammatory cytokines after agonist stimulation or bacterial invasion. (PubMed id 9277410)^{1, 9} Rowell D.L....Kagnoff M.F. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2921	HGNC: 4604	AceView: CXCL3	Ensembl:ENSG00000163734	euGenes: HUgn2921
ECgene: CXCL3	Kegg: 2921	H-InvDB: CXCL3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CXCL3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CXCL3	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/CXCL3

Intellectual Property for CXCL3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CXCL3 gene:
Search GeneIP for patents involving CXCL3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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CXCL3 Gene

chemokine (C-X-C motif) ligand 3

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CXCL3 Gene

chemokine (C-X-C motif) ligand 3

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