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Aliases for CXCL3 Gene

Aliases for CXCL3 Gene

  • Chemokine (C-X-C Motif) Ligand 3 2 3
  • GRO3 3 4 6
  • Macrophage Inflammatory Protein 2-Beta 3 4
  • Growth-Regulated Protein Gamma 3 4
  • GRO-Gamma(1-73) 3 4
  • GRO3 Oncogene 2 3
  • GRO-Gamma 3 4
  • MIP2-Beta 3 4
  • MIP2B 3 6
  • SCYB3 3 4
  • GROg 3 4
  • Melanoma Growth Stimulatory Activity Gamma 3
  • C-X-C Motif Chemokine 3 3
  • MGSA Gamma 3
  • CINC-2b 3
  • MIP-2b 3

External Ids for CXCL3 Gene

Previous HGNC Symbols for CXCL3 Gene

  • GRO3

Previous GeneCards Identifiers for CXCL3 Gene

  • GC04M074891
  • GC04M075141
  • GC04M075302
  • GC04M075368
  • GC04M075267
  • GC04M075121
  • GC04M070713

Summaries for CXCL3 Gene

Entrez Gene Summary for CXCL3 Gene

  • This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]

GeneCards Summary for CXCL3 Gene

CXCL3 (Chemokine (C-X-C Motif) Ligand 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include chemokine activity. An important paralog of this gene is PF4.

UniProtKB/Swiss-Prot for CXCL3 Gene

  • Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL3 Gene

Genomics for CXCL3 Gene

Regulatory Elements for CXCL3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CXCL3 Gene

Start:
74,036,589 bp from pter
End:
74,038,807 bp from pter
Size:
2,219 bases
Orientation:
Minus strand

Genomic View for CXCL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CXCL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL3 Gene

Proteins for CXCL3 Gene

  • Protein details for CXCL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19876-CXCL3_HUMAN
    Recommended name:
    C-X-C motif chemokine 3
    Protein Accession:
    P19876
    Secondary Accessions:
    • Q4W5H9

    Protein attributes for CXCL3 Gene

    Size:
    107 amino acids
    Molecular mass:
    11342 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CXCL3 Gene

Proteomics data for CXCL3 Gene at MOPED

Post-translational modifications for CXCL3 Gene

  • N-terminal processed form GRO-gamma(5-73) is produced by proteolytic cleavage after secretion from peripheral blood monocytes.

Other Protein References for CXCL3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CXCL3 (CXCL3/GRO gamma/CINC-2/DCIP-1)

Protein Products

No data available for DME Specific Peptides for CXCL3 Gene

Domains for CXCL3 Gene

Gene Families for CXCL3 Gene

HGNC:

Protein Domains for CXCL3 Gene

Suggested Antigen Peptide Sequences for CXCL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P19876

UniProtKB/Swiss-Prot:

CXCL3_HUMAN :
  • P19876
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL3: view

Function for CXCL3 Gene

Molecular function for CXCL3 Gene

UniProtKB/Swiss-Prot Function:
Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.

Gene Ontology (GO) - Molecular Function for CXCL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008009 chemokine activity ISS --
GO:0045236 CXCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with CXCL3: view

Animal Model Products

miRNA for CXCL3 Gene

miRTarBase miRNAs that target CXCL3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CXCL3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CXCL3 Gene

Localization for CXCL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CXCL3 Gene COMPARTMENTS Subcellular localization image for CXCL3 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for CXCL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 10095777
genes like me logo Genes that share ontologies with CXCL3: view

Pathways for CXCL3 Gene

genes like me logo Genes that share pathways with CXCL3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CXCL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002690 positive regulation of leukocyte chemotaxis IBA --
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IBA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0030593 neutrophil chemotaxis ISS --
genes like me logo Genes that share ontologies with CXCL3: view

Compounds for CXCL3 Gene

(5) Novoseek inferred chemical compound relationships for CXCL3 Gene

Compound -log(P) Hits PubMed IDs
grogamma 98.6 15
grobeta 96.5 13
groalpha 92.7 7
rantes 68.4 7
calcium 0 3
genes like me logo Genes that share compounds with CXCL3: view

Transcripts for CXCL3 Gene

mRNA/cDNA for CXCL3 Gene

Unigene Clusters for CXCL3 Gene

Chemokine (C-X-C motif) ligand 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CXCL3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL3 Gene

No ASD Table

Relevant External Links for CXCL3 Gene

GeneLoc Exon Structure for
CXCL3
ECgene alternative splicing isoforms for
CXCL3

Expression for CXCL3 Gene

mRNA expression in normal human tissues for CXCL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CXCL3 Gene

This gene is overexpressed in Lung (7.4), Stomach (6.4), and Heart - Atrial Appendage (4.5).

Protein differential expression in normal tissues for CXCL3 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CXCL3 Gene

SOURCE GeneReport for Unigene cluster for CXCL3 Gene Hs.89690

genes like me logo Genes that share expressions with CXCL3: view

Expression partners for CXCL3 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CXCL3 Gene

Orthologs for CXCL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCL3 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Cxcl2 35
  • 78.4 (n)
  • 69.01 (a)
Cxcl3 16
Cxcl1 36
  • 61 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CXCL3 35
  • 97.51 (n)
  • 96.26 (a)
CXCL3 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cxcl2 35
  • 75.59 (n)
  • 66.2 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 80 (a)
ManyToMany
CXCL3 36
  • 80 (a)
ManyToMany
GRO1 36
  • 51 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 41 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 36 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 39 (a)
OneToMany
Species with no ortholog for CXCL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL3 Gene

ENSEMBL:
Gene Tree for CXCL3 (if available)
TreeFam:
Gene Tree for CXCL3 (if available)

Paralogs for CXCL3 Gene

Paralogs for CXCL3 Gene

Selected SIMAP similar genes for CXCL3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CXCL3: view

Variants for CXCL3 Gene

Sequence variations from dbSNP and Humsavar for CXCL3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs181272 -- 74,037,647(-) TCAAC(A/G)TTATT intron-variant
rs352043 - 74,038,604(-) GGCCC(A/G)CGCCA reference, missense
rs370655 -- 74,037,417(-) ATAGA(A/G)GGCAG intron-variant
rs1051754 -- 74,036,810(-) TTTTT(A/T)AAAAA utr-variant-3-prime
rs3048371 -- 74,037,463(+) TTTTT(-/TT)CAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CXCL3 Gene

Variant ID Type Subtype PubMed ID
nsv525980 CNV Gain 19592680

Relevant External Links for CXCL3 Gene

HapMap Linkage Disequilibrium report
CXCL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL3 Gene

Disorders for CXCL3 Gene

(6) Novoseek inferred disease relationships for CXCL3 Gene

Disease -log(P) Hits PubMed IDs
colon carcinoma 43.3 2
necrosis 38.4 2
osteosarcoma 37.7 1
inflammation 26.8 1
tumors 23.8 3

Relevant External Links for CXCL3

Genetic Association Database (GAD)
CXCL3
Human Genome Epidemiology (HuGE) Navigator
CXCL3
genes like me logo Genes that share disorders with CXCL3: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for CXCL3 Gene

Publications for CXCL3 Gene

  1. Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues. (PMID: 2201751) Tekamp-Olson P. … Cerami A. (J. Exp. Med. 1990) 3 4 23
  2. Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms. (PMID: 10095777) Wuyts A. … Van Damme J. (Eur. J. Biochem. 1999) 3 4 23
  3. Identification of three related human GRO genes encoding cytokine functions. (PMID: 2217207) Haskill S. … Sager R. (Proc. Natl. Acad. Sci. U.S.A. 1990) 2 3 4
  4. Role of IKK and ERK pathways in intrinsic inflammation of cystic fibrosis airways. (PMID: 17466952) Verhaeghe C. … Bours V. (Biochem. Pharmacol. 2007) 3 23
  5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4

Products for CXCL3 Gene

Sources for CXCL3 Gene

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