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Aliases for CXCL3 Gene

Aliases for CXCL3 Gene

  • C-X-C Motif Chemokine Ligand 3 2 3 5
  • Macrophage Inflammatory Protein 2-Beta 3 4
  • Chemokine (C-X-C Motif) Ligand 3 2 3
  • Growth-Regulated Protein Gamma 3 4
  • GRO-Gamma(1-73) 3 4
  • GRO3 Oncogene 2 3
  • GRO-Gamma 3 4
  • MIP2-Beta 3 4
  • SCYB3 3 4
  • GROg 3 4
  • GRO3 3 4
  • Melanoma Growth Stimulatory Activity Gamma 3
  • C-X-C Motif Chemokine 3 3
  • MGSA Gamma 3
  • CINC-2b 3
  • MIP-2b 3
  • MIP2B 3

External Ids for CXCL3 Gene

Previous HGNC Symbols for CXCL3 Gene

  • GRO3

Previous GeneCards Identifiers for CXCL3 Gene

  • GC04M074891
  • GC04M075141
  • GC04M075302
  • GC04M075368
  • GC04M075267
  • GC04M075121
  • GC04M070713

Summaries for CXCL3 Gene

Entrez Gene Summary for CXCL3 Gene

  • This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]

GeneCards Summary for CXCL3 Gene

CXCL3 (C-X-C Motif Chemokine Ligand 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include chemokine activity and CXCR chemokine receptor binding. An important paralog of this gene is CXCL2.

UniProtKB/Swiss-Prot for CXCL3 Gene

  • Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL3 Gene

Genomics for CXCL3 Gene

Regulatory Elements for CXCL3 Gene

Enhancers for CXCL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F073660 1.2 FANTOM5 Ensembl ENCODE 53.6 +376.4 376411 3.3 CTCF ATF1 JUN RAD21 YY1 ZNF664 SMC3 FOS MAFK ZNF654 CXCL3 CXCL2 CXCL8 RASSF6 MTHFD2L PF4V1 LOC105377272
GH04F073725 1.6 FANTOM5 Ensembl ENCODE 40.1 +312.5 312508 2.0 JUN CEBPB EP300 JUND ZNF366 IKZF1 ZNF512 FOS NFE2 MAFK CXCL2 CXCL8 CXCL3 MTHFD2L PF4V1 LOC105377272
GH04F073720 1.1 FANTOM5 Ensembl ENCODE 37.2 +316.9 316859 2.0 JUN CEBPB CEBPG EP300 ZBTB40 JUND ATF3 TRIM24 FOXP2 CXCL8 CXCL2 CXCL3 MTHFD2L PF4V1 LOC105377272 CXCL5
GH04F073729 1.3 FANTOM5 Ensembl ENCODE 36.4 +306.2 306207 7.2 PKNOX1 ATF1 TBL1XR1 BMI1 ZBTB40 RAD21 CBX5 ZNF143 ETV6 CREM CXCL8 CXCL2 CXCL3 PF4V1 MTHFD2L ANKRD17 CXCL1 LOC105377272
GH04F073702 1.3 FANTOM5 Ensembl ENCODE 32.7 +332.5 332507 7.4 PKNOX1 ARNT CREB3L1 SIN3A FEZF1 FOS KLF13 JUNB REST MEF2D CXCL8 CXCL2 CXCL3 MTHFD2L PF4V1 LOC105377272 CXCL5 ANKRD17 CXCL1 RASSF6
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CXCL3 on UCSC Golden Path with GeneCards custom track

Promoters for CXCL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001242891 506 2600 ATF1 PKNOX1 CREB3L1 SIN3A GLIS2 GATA2 ZNF263 SP3 REST SMARCA4

Genomic Location for CXCL3 Gene

Chromosome:
4
Start:
74,036,589 bp from pter
End:
74,038,807 bp from pter
Size:
2,219 bases
Orientation:
Minus strand

Genomic View for CXCL3 Gene

Genes around CXCL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL3 Gene

Proteins for CXCL3 Gene

  • Protein details for CXCL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19876-CXCL3_HUMAN
    Recommended name:
    C-X-C motif chemokine 3
    Protein Accession:
    P19876
    Secondary Accessions:
    • Q4W5H9

    Protein attributes for CXCL3 Gene

    Size:
    107 amino acids
    Molecular mass:
    11342 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CXCL3 Gene

Post-translational modifications for CXCL3 Gene

  • N-terminal processed form GRO-gamma(5-73) is produced by proteolytic cleavage after secretion from peripheral blood monocytes.

Other Protein References for CXCL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CXCL3 (CXCL3/GRO gamma/CINC-2/DCIP-1)

No data available for DME Specific Peptides for CXCL3 Gene

Domains & Families for CXCL3 Gene

Gene Families for CXCL3 Gene

Suggested Antigen Peptide Sequences for CXCL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P19876

UniProtKB/Swiss-Prot:

CXCL3_HUMAN :
  • Belongs to the intercrine alpha (chemokine CxC) family.
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL3: view

Function for CXCL3 Gene

Molecular function for CXCL3 Gene

UniProtKB/Swiss-Prot Function:
Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.

Gene Ontology (GO) - Molecular Function for CXCL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008009 chemokine activity IEA,ISS --
GO:0045236 CXCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with CXCL3: view

Phenotypes for CXCL3 Gene

genes like me logo Genes that share phenotypes with CXCL3: view

Animal Model Products

miRNA for CXCL3 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CXCL3 Gene

Localization for CXCL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CXCL3 Gene COMPARTMENTS Subcellular localization image for CXCL3 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for CXCL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA,IDA 10095777
genes like me logo Genes that share ontologies with CXCL3: view

Pathways & Interactions for CXCL3 Gene

genes like me logo Genes that share pathways with CXCL3: view

Gene Ontology (GO) - Biological Process for CXCL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0006952 defense response IEA --
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IEA,IBA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with CXCL3: view

No data available for SIGNOR curated interactions for CXCL3 Gene

Drugs & Compounds for CXCL3 Gene

(1) Drugs for CXCL3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for CXCL3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CXCL3: view

Transcripts for CXCL3 Gene

Unigene Clusters for CXCL3 Gene

Chemokine (C-X-C motif) ligand 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL3 Gene

No ASD Table

Relevant External Links for CXCL3 Gene

GeneLoc Exon Structure for
CXCL3
ECgene alternative splicing isoforms for
CXCL3

Expression for CXCL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CXCL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CXCL3 Gene

This gene is overexpressed in Lung (x7.4), Stomach (x6.4), and Heart - Atrial Appendage (x4.5).

Protein differential expression in normal tissues from HIPED for CXCL3 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CXCL3 Gene



Protein tissue co-expression partners for CXCL3 Gene

NURSA nuclear receptor signaling pathways regulating expression of CXCL3 Gene:

CXCL3

SOURCE GeneReport for Unigene cluster for CXCL3 Gene:

Hs.89690
genes like me logo Genes that share expression patterns with CXCL3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CXCL3 Gene

Orthologs for CXCL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXCL3 34 35
  • 97.51 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 80 (a)
ManyToMany
CXCL3 35
  • 80 (a)
ManyToMany
GRO1 35
  • 51 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cxcl2 34 16
  • 78.4 (n)
Cxcl1 35
  • 61 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cxcl2 34
  • 75.59 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 57 (a)
ManyToMany
-- 35
  • 54 (a)
ManyToMany
-- 35
  • 51 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 41 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 36 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 39 (a)
OneToMany
Species where no ortholog for CXCL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL3 Gene

ENSEMBL:
Gene Tree for CXCL3 (if available)
TreeFam:
Gene Tree for CXCL3 (if available)

Paralogs for CXCL3 Gene

Paralogs for CXCL3 Gene

(15) SIMAP similar genes for CXCL3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CXCL3: view

Variants for CXCL3 Gene

Sequence variations from dbSNP and Humsavar for CXCL3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1051754 -- 74,036,810(-) TTTTT(A/T)AAAAA upstream-variant-2KB, utr-variant-3-prime
rs10658871 -- 74,037,448(+) AATGC(-/T)TTTTT intron-variant, upstream-variant-2KB
rs111615115 -- 74,036,548(+) GAAGA(A/G)CTAAA downstream-variant-500B
rs112785228 -- 74,036,957(+) CACTA(A/G)ATATT upstream-variant-2KB, utr-variant-3-prime
rs112910913 -- 74,036,436(+) GCATC(A/G)GATAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CXCL3 Gene

Variant ID Type Subtype PubMed ID
esv3575747 CNV gain 25503493
nsv1004768 CNV gain 25217958
nsv1006029 CNV gain 25217958
nsv525980 CNV gain 19592680

Variation tolerance for CXCL3 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CXCL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXCL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL3 Gene

Disorders for CXCL3 Gene

Relevant External Links for CXCL3

Genetic Association Database (GAD)
CXCL3
Human Genome Epidemiology (HuGE) Navigator
CXCL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CXCL3

No disorders were found for CXCL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CXCL3 Gene

Publications for CXCL3 Gene

  1. Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms. (PMID: 10095777) Wuyts A. … Van Damme J. (Eur. J. Biochem. 1999) 3 4 22 64
  2. Identification of three related human GRO genes encoding cytokine functions. (PMID: 2217207) Haskill S. … Sager R. (Proc. Natl. Acad. Sci. U.S.A. 1990) 2 3 4 64
  3. Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues. (PMID: 2201751) Tekamp-Olson P. … Cerami A. (J. Exp. Med. 1990) 3 4 22 64
  4. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L. … Crovella S. (Vaccine 2010) 3 46 64
  5. Differential expression of the chemokines GRO-2, GRO-3, and interleukin-8 in colon cancer and their impact on metastatic disease and survival. (PMID: 20162422) Doll D. … Janssen K.P. (Int J Colorectal Dis 2010) 3 22 64

Products for CXCL3 Gene

Sources for CXCL3 Gene

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