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Aliases for CXCL3 Gene

Aliases for CXCL3 Gene

  • C-X-C Motif Chemokine Ligand 3 2 3
  • Chemokine (C-X-C Motif) Ligand 3 2 3 5
  • Macrophage Inflammatory Protein 2-Beta 3 4
  • Growth-Regulated Protein Gamma 3 4
  • GRO-Gamma(1-73) 3 4
  • GRO3 Oncogene 2 3
  • GRO-Gamma 3 4
  • MIP2-Beta 3 4
  • SCYB3 3 4
  • GROg 3 4
  • GRO3 3 4
  • Melanoma Growth Stimulatory Activity Gamma 3
  • MGSA Gamma 3
  • CINC-2b 3
  • MIP-2b 3
  • MIP2B 3

External Ids for CXCL3 Gene

Previous HGNC Symbols for CXCL3 Gene

  • GRO3

Previous GeneCards Identifiers for CXCL3 Gene

  • GC04M074891
  • GC04M075141
  • GC04M075302
  • GC04M075368
  • GC04M075267
  • GC04M075121
  • GC04M070713

Summaries for CXCL3 Gene

Entrez Gene Summary for CXCL3 Gene

  • This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]

GeneCards Summary for CXCL3 Gene

CXCL3 (C-X-C Motif Chemokine Ligand 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and ERK Signaling. GO annotations related to this gene include chemokine activity and CXCR chemokine receptor binding. An important paralog of this gene is PF4.

UniProtKB/Swiss-Prot for CXCL3 Gene

  • Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL3 Gene

Genomics for CXCL3 Gene

Regulatory Elements for CXCL3 Gene

Promoters for CXCL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CXCL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CXCL3 Gene

Chromosome:
4
Start:
74,036,589 bp from pter
End:
74,038,807 bp from pter
Size:
2,219 bases
Orientation:
Minus strand

Genomic View for CXCL3 Gene

Genes around CXCL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL3 Gene

Proteins for CXCL3 Gene

  • Protein details for CXCL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19876-CXCL3_HUMAN
    Recommended name:
    C-X-C motif chemokine 3
    Protein Accession:
    P19876
    Secondary Accessions:
    • Q4W5H9

    Protein attributes for CXCL3 Gene

    Size:
    107 amino acids
    Molecular mass:
    11342 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CXCL3 Gene

Proteomics data for CXCL3 Gene at MOPED

Post-translational modifications for CXCL3 Gene

  • N-terminal processed form GRO-gamma(5-73) is produced by proteolytic cleavage after secretion from peripheral blood monocytes.

Other Protein References for CXCL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CXCL3 (CXCL3/GRO gamma/CINC-2/DCIP-1)

No data available for DME Specific Peptides for CXCL3 Gene

Domains & Families for CXCL3 Gene

Gene Families for CXCL3 Gene

Protein Domains for CXCL3 Gene

Suggested Antigen Peptide Sequences for CXCL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P19876

UniProtKB/Swiss-Prot:

CXCL3_HUMAN :
  • Belongs to the intercrine alpha (chemokine CxC) family.
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL3: view

Function for CXCL3 Gene

Molecular function for CXCL3 Gene

UniProtKB/Swiss-Prot Function:
Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.

Phenotypes for CXCL3 Gene

GenomeRNAi human phenotypes for CXCL3:
genes like me logo Genes that share phenotypes with CXCL3: view

Animal Model Products

miRNA for CXCL3 Gene

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CXCL3 Gene

Localization for CXCL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CXCL3 Gene COMPARTMENTS Subcellular localization image for CXCL3 gene
Compartment Confidence
extracellular 5
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for CXCL3 Gene

Pathways & Interactions for CXCL3 Gene

genes like me logo Genes that share pathways with CXCL3: view

Gene Ontology (GO) - Biological Process for CXCL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0030593 neutrophil chemotaxis ISS --
GO:0032496 response to lipopolysaccharide IBA --
GO:0090023 positive regulation of neutrophil chemotaxis IBA --
genes like me logo Genes that share ontologies with CXCL3: view

No data available for SIGNOR curated interactions for CXCL3 Gene

Drugs & Compounds for CXCL3 Gene

(1) Drugs for CXCL3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for CXCL3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CXCL3: view

Transcripts for CXCL3 Gene

Unigene Clusters for CXCL3 Gene

Chemokine (C-X-C motif) ligand 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL3 Gene

No ASD Table

Relevant External Links for CXCL3 Gene

GeneLoc Exon Structure for
CXCL3
ECgene alternative splicing isoforms for
CXCL3

Expression for CXCL3 Gene

mRNA expression in normal human tissues for CXCL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CXCL3 Gene

This gene is overexpressed in Lung (x7.4), Stomach (x6.4), and Heart - Atrial Appendage (x4.5).

Protein differential expression in normal tissues from HIPED for CXCL3 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CXCL3 Gene



SOURCE GeneReport for Unigene cluster for CXCL3 Gene Hs.89690

genes like me logo Genes that share expression patterns with CXCL3: view

Protein tissue co-expression partners for CXCL3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CXCL3 Gene

Orthologs for CXCL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXCL3 36
  • 96 (a)
OneToOne
CXCL3 35
  • 97.51 (n)
  • 96.26 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 80 (a)
ManyToMany
CXCL3 36
  • 80 (a)
ManyToMany
GRO1 36
  • 51 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cxcl2 16
Cxcl2 35
  • 78.4 (n)
  • 69.01 (a)
Cxcl1 36
  • 61 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 41 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cxcl2 35
  • 75.59 (n)
  • 66.2 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 36 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 39 (a)
OneToMany
Species with no ortholog for CXCL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL3 Gene

ENSEMBL:
Gene Tree for CXCL3 (if available)
TreeFam:
Gene Tree for CXCL3 (if available)

Paralogs for CXCL3 Gene

Paralogs for CXCL3 Gene

(15) SIMAP similar genes for CXCL3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CXCL3: view

Variants for CXCL3 Gene

Sequence variations from dbSNP and Humsavar for CXCL3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_059210 -
rs4694662 -- 74,036,566(+) AAGAA(G/T)TTTTT downstream-variant-500B
rs191598824 -- 74,036,195(+) ACTTT(C/T)CTACC downstream-variant-500B
rs200713242 -- 74,036,632(+) CAAAT(A/G)TAACA utr-variant-3-prime
rs199742726 -- 74,036,622(+) GTCAT(C/T)TGTAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CXCL3 Gene

Variant ID Type Subtype PubMed ID
nsv525980 CNV Gain 19592680

Variation tolerance for CXCL3 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CXCL3 Gene

HapMap Linkage Disequilibrium report
CXCL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL3 Gene

Disorders for CXCL3 Gene

Relevant External Links for CXCL3

Genetic Association Database (GAD)
CXCL3
Human Genome Epidemiology (HuGE) Navigator
CXCL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CXCL3

No disorders were found for CXCL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CXCL3 Gene

Publications for CXCL3 Gene

  1. Identification of three related human GRO genes encoding cytokine functions. (PMID: 2217207) Haskill S. … Sager R. (Proc. Natl. Acad. Sci. U.S.A. 1990) 2 3 4 67
  2. Differential expression of the chemokines GRO-2, GRO-3, and interleukin-8 in colon cancer and their impact on metastatic disease and survival. (PMID: 20162422) Doll D. … Janssen K.P. (Int J Colorectal Dis 2010) 3 23
  3. Role of IKK and ERK pathways in intrinsic inflammation of cystic fibrosis airways. (PMID: 17466952) Verhaeghe C. … Bours V. (Biochem. Pharmacol. 2007) 3 23
  4. Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms. (PMID: 10095777) Wuyts A. … Van Damme J. (Eur. J. Biochem. 1999) 3 23
  5. Human hepatocytes express an array of proinflammatory cytokines after agonist stimulation or bacterial invasion. (PMID: 9277410) Rowell D.L. … Kagnoff M.F. (Am. J. Physiol. 1997) 3 23

Products for CXCL3 Gene

Sources for CXCL3 Gene

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