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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CXCL2 Gene

protein-coding   GIFtS: 58
GCID: GC04M074962

Chemokine (C-X-C Motif) Ligand 2

(Previous name: GRO2 oncogene)
(Previous symbol: GRO2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chemokine (C-X-C Motif) Ligand 21 2     MGSA-b2
GRO21 2 3 5     MIP-2a2
MIP2A2 3 5     MIP22
GRO2 Oncogene1 2     C-X-C Motif Chemokine 22
Growth-Regulated Protein Beta2 3     gro-beta2
Macrophage Inflammatory Protein 2-Alpha2 3     Melanoma Growth Stimulatory Activity Beta2
MIP2-alpha2 3     MGSA Beta2
SCYB22 3     GROB3
CINC-2a2     Gro-beta3
GROb2     

External Ids:    HGNC: 46031   Entrez Gene: 29202   Ensembl: ENSG000000810417   OMIM: 1391105   UniProtKB: P198753   

Export aliases for CXCL2 gene to outside databases

Previous GC identifers: GC04M074951 GC04M075202 GC04M075363 GC04M075429 GC04M075329 GC04M070774


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CXCL2 Gene: 
CXCL2 (chemokine (C-X-C motif) ligand 2) is a protein-coding gene. Diseases associated with CXCL2 include acanthamoeba keratitis, and human monocytic ehrlichiosis, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Chemokine signaling pathway. GO annotations related to this gene include chemokine activity. An important paralog of this gene is PPBP.

UniProtKB/Swiss-Prot: CXCL2_HUMAN, P19875
Function: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory
chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly
enhanced hematopoietic activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_022778.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CXCL2 gene promoter:
         TBP   PPAR-gamma1   AML1a   TFIID   PPAR-gamma2   NF-E2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXCL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CXCL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3

CXCL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCL2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M074962:  view genomic region     (about GC identifiers)

Start:
74,962,752 bp from pter      End:
74,965,010 bp from pter
Size:
2,259 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CXCL2_HUMAN, P19875 (See protein sequence)
Recommended Name: C-X-C motif chemokine 2 precursor  
Size: 107 amino acids; 11389 Da
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for CXCL2:
1QNK (3D)    
Secondary accessions: Q6FGD6 Q9UPB8

Explore the universe of human proteins at neXtProt for CXCL2: NX_P19875

Explore proteomics data for CXCL2 at MOPED 

Post-translational modifications:

  • UniProtKB: The N-terminal processed form GRO-beta(5-73) is produced by proteolytic cleavage after secretion from bone marrow
    stromal cells
  • View neXtProt modification sites for NX_P19875

  • CXCL2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CXCL2 Protein Expression
    REFSEQ proteins: NP_002080.1  
    ENSEMBL proteins: 
     ENSP00000427279  
    Reactome Protein details: P19875
    Human Recombinant Protein Products for CXCL2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CXCL2 (CXCL2/GRO beta/MIP-2/CINC-3)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CXCL2
    OriGene Protein Over-expression Lysate for CXCL2
    OriGene MassSpec for CXCL2 
    OriGene Custom Protein Services for CXCL2
    GenScript Purified and Recombinant Proteins for CXCL2
    Novus Biologicals CXCL2 Proteins
    Novus Biologicals CXCL2 Lysate
    Sino Biological Recombinant Protein for CXCL2
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CXCL2
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    CXCL2 for ontologies           About GeneDecksing



    CXCL2 Antibody Products: 
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    Assay Products for CXCL2: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CXCL2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands

    3 InterPro protein domains:
     IPR001811 Chemokine_IL8-like_dom
     IPR001089 Chemokine_CXC
     IPR018048 Chemokine_CXC_CS

    Graphical View of Domain Structure for InterPro Entry P19875

    ProtoNet protein and cluster: P19875

    1 Blocks protein domain: IPB002473 Interleukin-8 signature

    UniProtKB/Swiss-Prot: CXCL2_HUMAN, P19875
    Similarity: Belongs to the intercrine alpha (chemokine CxC) family


    CXCL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CXCL2_HUMAN, P19875
    Function: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory
    chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly
    enhanced hematopoietic activity

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18275857
    GO:0008009chemokine activity IEA--
         
    CXCL2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CXCL2:
     Decreased focal adhesion (FA)   Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CXCL2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CXCL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CXCL2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CXCL2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCL2
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL2 (see all 11):
    hsa-miR-3163 hsa-miR-607 hsa-miR-409-3p hsa-miR-128 hsa-miR-3681* hsa-miR-3617 hsa-miR-421 hsa-miR-641
    SwitchGear 3'UTR luciferase reporter plasmidCXCL2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CXCL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCL2

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CXCL2

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector: CXCL2 (NM_002089)
    Sino Biological Human cDNA Clone for CXCL2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL2
    Sirion Biotech Customized lentivirus for stable overexpression of CXCL2 
                         Customized lentivirus expression plasmids for stable overexpression of CXCL2 

    Cell Line
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    Search LifeMap BioReagents cell lines for CXCL2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CXCL2 About   (see all 16)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    IL-6 Pathway0.61
    MIF Regulation of Innate Immune Cells0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43
    2Chemokine Signaling
    Chemokine Signaling0.33
    Chemokine signaling pathway0.33
    3Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.46
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    5Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CXCL2 (see all 17)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    MIF Mediated Glucocorticoid Regulation

    2 BioSystems Pathways for CXCL2
        Cytokines and Inflammatory Response
    Spinal Cord Injury


    5/8        Reactome Pathways for CXCL2 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    5/7         Kegg Pathways  (Kegg details for CXCL2) (see all 7):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    NF-kappa B signaling pathway
    NOD-like receptor signaling pathway
    TNF signaling pathway


    CXCL2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CXCL2

    5/14 Interacting proteins for CXCL2 (P198752, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DPP4P274872, 3MINT-8091061 I2D: score=1 
    CXCR2P250253I2D: score=3 
    CXCR1P250243I2D: score=2 
    MMP12P399003I2D: score=2 
    ELOF1P600023I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002237response to molecule of bacterial origin IDA19912257
    GO:0006935chemotaxis IEA--
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--

    CXCL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CXCL2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CXCL2

    UniProtKB/Swiss-Prot: CXCL2_HUMAN, P19875
    Pharmaceutical: GRO-beta(5-73) is available under the name Garnocestim as immunomodulator. It is used prior to
    hematopoietic transplantation for peripheral blood stem cell mobilization and reduction of incidence, duration,
    and/or severity of chemotherapy induced cytopenias

    10/41 Novoseek inferred chemical compound relationships for CXCL2 gene (see all 41)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    grobeta 92.1 37 8702798 (5), 16540656 (4), 15292528 (3), 19435811 (2) (see all 13)
    grogamma 91.3 15 8702798 (5), 15832427 (2), 9553055 (2), 10695618 (1) (see all 8)
    groalpha 81.6 12 8702798 (2), 16540656 (2), 10695618 (1), 19435811 (1) (see all 9)
    rantes 73.5 41 10505748 (3), 17015748 (3), 7682242 (2), 10531235 (2) (see all 28)
    ccl3 68.7 10 15585879 (2), 14734774 (1), 16552065 (1), 19067439 (1) (see all 8)
    tmtu 59.2 2 9726445 (1), 9707512 (1)
    tarc 46.1 4 15941911 (2), 20308302 (1), 11001915 (1)
    endotoxin 42.5 4 11705739 (2), 14504103 (1), 10768990 (1)
    ccl4 29.5 7 14734774 (1), 19120450 (1), 16552065 (1), 18340639 (1) (see all 6)
    8-oxo-dg 24.9 1 15337697 (1)

    Search CenterWatch for drugs/clinical trials and news about CXCL2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CXCL2 gene: 
    NM_002089.3  

    Unigene Cluster for CXCL2:

    Chemokine (C-X-C motif) ligand 2
    Hs.75765  [show with all ESTs]
    Unigene Representative Sequence: NM_002089
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508487(uc003hhm.4) ENST00000296031 ENST00000510048
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCL2
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL2 (see all 11):
    hsa-miR-3163 hsa-miR-607 hsa-miR-409-3p hsa-miR-128 hsa-miR-3681* hsa-miR-3617 hsa-miR-421 hsa-miR-641
    SwitchGear 3'UTR luciferase reporter plasmidCXCL2 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCL2
    Clone
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    GenScript: all cDNA clones in your preferred vector: CXCL2 (NM_002089)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL2
    Sirion Biotech Customized lentivirus for stable overexpression of CXCL2 
                         Customized lentivirus expression plasmids for stable overexpression of CXCL2 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXCL2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL2

    Additional mRNA sequence: 

    AF043340.1 AK308504.1 AK311304.1 BC015753.1 CR542171.1 M36820.1 M57731.1 X53799.1 

    10 DOTS entries:

    DT.40314945  DT.40313580  DT.101968867  DT.121273395  DT.100786999  DT.95299876  DT.92445243  DT.95299860 
    DT.100786997  DT.101987218 

    24/122 AceView cDNA sequences (see all 122):

    CR542171 CR601860 BX397603 BM768469 X53799 BM761152 BM923815 CA309975 
    BM772327 BM771156 CA865443 CR617096 CD240332 BM749667 AA362186 CD367441 
    AW103962 CR602080 C02042 AA487664 CA865685 BF847972 BM756509 BM763035 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CXCL2 expression in normal human tissues (normalized intensities)      CXCL2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGAAGCTTT
    CXCL2 Expression
    About this image


    CXCL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 3 entries
             Duct Cells Pancreatic Ducts
             Pancreatic endoderm/endocrine precursor-like cells ( A scalable, suspension protocol...
             Pancreatic Islet   
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Human Umbilical Vein Smooth Muscle Cells (HUVSMC)   
             cd31+ cells   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 3 entries
             Human Umbillical Artery Smooth Muscle Cells (HUASMC)   
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
             cd31+ cells   
     
     Smooth Muscle (Muscoskeletal System)
             Human Umbillical Artery Smooth Muscle Cells (HUASMC)   

    See CXCL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CXCL2

    SOURCE GeneReport for Unigene cluster: Hs.75765
        SABiosciences Expression via Pathway-Focused PCR Arrays including CXCL2 (see all 20): 
              Neurogenesis in human mouse rat
              Wound Healing in human mouse rat
              Inflammasomes in human mouse rat
              Notch Signaling Targets in human mouse rat
              Th17 Response in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CXCL2 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cxcl25
    Cxcl11
    chemokine (C-X-C motif) ligand 25
    chemokine (C-X-C motif) ligand 11
    77.04(n)1
    70(a)1
      5 (44.78 cM)5
    148251  NM_008176.31  NP_032202.11 
     909038995 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    34(a)
    possible ortholog
    4(50379773-50381069)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    38(a)
    possible ortholog
    6(60123888-60134622)


    ENSEMBL Gene Tree for CXCL2 (if available)
    TreeFam Gene Tree for CXCL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CXCL2 gene
    PPBP2  PF42  CXCL12  PF4V12  CXCL62  CXCL32  CXCL52  IL82  
    13 SIMAP similar genes for CXCL2 using alignment to 1 protein entry:     CXCL2_HUMAN:
    CXCL3    CXCL1    PPBP    CXCL9    CXCL5    CXCL6
    CXCL10    PF4    PF4V1    IL8    CXCL11    CXCL12
    CXCL14

    CXCL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/179 SNPs in CXCL2 are shown (see all 179)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1449677661,2
    --74962269(+) TGTAAC/GCTGTT 1 -- ds50010--------
    rs1877215911,2
    --74962527(+) TATCAC/GTGATT 1 -- ds50010--------
    rs1490538851,2
    --74962615(+) ACCACA/GTGAAA 1 -- ds50010--------
    rs1923842001,2
    --74962642(+) GTTTAC/TCTGTA 1 -- ds50010--------
    rs1855752411,2
    C--74962698(+) GTAAAA/TCATCA 1 -- ds50010--------
    rs1152117581,2
    --74962767(+) TTAAAA/TATTTT 1 -- ut310--------
    rs91311,2
    C,F,O,A,H--74963049(-) CCAGTA/GAGATC 1 -- ut31 ese335Minor allele frequency- N:0.00MN EA NA NS WA 3727
    rs1433677141,2
    C--74963072(+) ATTCCC/TCAGCC 1 -- ut310--------
    rs1512973311,2
    C--74963209(+) CTAAAA/GTAAAC 1 -- ut310--------
    rs339504861,2
    C--74963303(+) CAAAC-/A/A   
       AAT
    /T
    TAAAT
    3 -- ut310--------

    HapMap Linkage Disequilibrium report for CXCL2 (74962752 - 74965010 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CXCL2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv525980CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 139110    OMIM disorders: --

    20/50 diseases for CXCL2 (see all 50):    About MalaCards
    acanthamoeba keratitis    human monocytic ehrlichiosis    stachybotrys chartarum    arthus reaction
    clostridium difficile    ehrlichiosis    keratitis    meningoencephalitis
    autoimmune myocarditis    myocarditis    extrinsic allergic alveolitis    peritonitis
    glycogen storage disease    gastritis    ulcerative colitis    vaginitis
    pyelonephritis    meningitis    sickle cell disease    candidiasis


    CXCL2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/33 Novoseek inferred disease relationships for CXCL2 gene (see all 33)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 65 23 19515386 (2), 11292716 (1), 11303726 (1), 10453028 (1) (see all 18)
    bronchoalveolar lavage fluid 63 13 16046875 (1), 10358192 (1), 16424224 (1), 16002559 (1) (see all 12)
    necrosis 58 56 2104219 (1), 18266468 (1), 20012648 (1), 14507887 (1) (see all 53)
    pneumonia 53.2 2 15320896 (1), 19522764 (1)
    pulmonary infection 41.3 1 10768990 (1)
    sepsis 41.3 12 17944017 (3), 15614130 (2), 11373406 (1), 19184349 (1) (see all 7)
    tumors 35.1 70 16424980 (4), 17561115 (4), 7927176 (2), 2104219 (1) (see all 51)
    peritonitis 32.1 7 15614130 (2), 11231849 (2), 11755216 (2), 11303726 (1)
    histopathology 30 2 19815632 (1), 11705739 (1)
    keratitis 24.7 6 12565810 (3)

    Genetic Association Database (GAD): CXCL2
    Human Genome Epidemiology (HuGE) Navigator: CXCL2 (9 documents)

    Export disorders for CXCL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CXCL2 gene, integrated from 9 sources (see all 415):
    (articles sorted by number of sources associating them with CXCL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of three related human GRO genes encoding cytokine functions. (PubMed id 2217207)1, 2, 3, 9 Haskill S.... Sager R. (1990)
    2. Identification of unique truncated KC/GRO beta chemokines with potent hematopoietic and anti-infective activities. (PubMed id 10725737)1, 2, 9 King A.G....Pelus L.M. (2000)
    3. A CXCL2 polymorphism is associated with better outcomes in patients with severe sepsis. (PubMed id 17944017)1, 4, 9 Villar J....Kacmarek R.M. (2007)
    4. Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues. (PubMed id 2201751)1, 2, 9 Tekamp-Olson P.... Cerami A. (1990)
    5. Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue. (PubMed id 2078213)1, 2, 9 Iida N. and Grotendorst G.R. (1990)
    6. Genome-wide association study of white blood cell cou nt in 16,388 African Americans: the continental origins and genetic epidemiolog y network (COGENT). (PubMed id 21738479)1, 4 Reiner A.P....Wilson J.G. (2011)
    7. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)
    8. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)
    9. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (2007)
    10. A CXCL2 tandem repeat promoter polymorphism is associated with susceptibility to severe sepsis in the Spanish population. (PubMed id 16421598)1, 4 Flores C.... . (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2920 HGNC: 4603 AceView: CXCL2 Ensembl:ENSG00000081041 euGenes: HUgn2920
    ECgene: CXCL2 Kegg: 2920 H-InvDB: CXCL2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CXCL2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CXCL2 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CXCL2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CXCL2 gene:
    Search GeneIP for patents involving CXCL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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