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CXCL2 Gene

protein-coding   GIFtS: 58
GCID: GC04M074962

Chemokine (C-X-C Motif) Ligand 2

(Previous name: GRO2 oncogene)
(Previous symbol: GRO2)
  See CXCL2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-X-C Motif) Ligand 21 2     MGSA-b2
GRO21 2 3 5     MIP-2a2
MIP2A2 3 5     MIP22
GRO2 Oncogene1 2     C-X-C Motif Chemokine 22
Growth-Regulated Protein Beta2 3     gro-beta2
Macrophage Inflammatory Protein 2-Alpha2 3     Melanoma Growth Stimulatory Activity Beta2
MIP2-alpha2 3     MGSA Beta2
SCYB22 3     GROB3
CINC-2a2     Gro-beta3
GROb2     

External Ids:    HGNC: 46031   Entrez Gene: 29202   Ensembl: ENSG000000810417   OMIM: 1391105   UniProtKB: P198753   

Export aliases for CXCL2 gene to outside databases

Previous GC identifers: GC04M074951 GC04M075202 GC04M075363 GC04M075429 GC04M075329 GC04M070774


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CXCL2 Gene:
CXCL2 (chemokine (C-X-C motif) ligand 2) is a protein-coding gene. Diseases associated with CXCL2 include acanthamoeba keratitis, and stachybotrys chartarum. GO annotations related to this gene include chemokine activity. An important paralog of this gene is PPBP.

UniProtKB/Swiss-Prot: CXCL2_HUMAN, P19875
Function: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory
chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly
enhanced hematopoietic activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CXCL2 gene promoter:
         TBP   PPAR-gamma1   AML1a   TFIID   PPAR-gamma2   NF-E2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXCL2 promoter sequence
   Search Chromatin IP Primers for CXCL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CXCL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3

CXCL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCL2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M074962:  view genomic region     (about GC identifiers)

Start:
74,962,752 bp from pter      End:
74,965,010 bp from pter
Size:
2,259 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CXCL2_HUMAN, P19875 (See protein sequence)
Recommended Name: C-X-C motif chemokine 2 precursor  
Size: 107 amino acids; 11389 Da
1 PDB 3D structure from and Proteopedia for CXCL2:
1QNK (3D)    
Secondary accessions: Q6FGD6 Q9UPB8

Explore the universe of human proteins at neXtProt for CXCL2: NX_P19875

Explore proteomics data for CXCL2 at MOPED

Post-translational modifications: 

  • The N-terminal processed form GRO-beta(5-73) is produced by proteolytic cleavage after secretion from bone marrow
    stromal cells1
  • Modification sites at neXtProt

  • See CXCL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002080.1  
    ENSEMBL proteins: 
     ENSP00000427279  
    Reactome Protein details: P19875

    CXCL2 Human Recombinant Protein Products:

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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CXCL2
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    OriGene MassSpec for CXCL2
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    GenScript Purified and Recombinant Proteins for CXCL2
    Novus Biologicals CXCL2 Proteins
    Novus Biologicals CXCL2 Lysate
    Sino Biological Recombinant Protein for CXCL2
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CXCL2
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CXCL2 

     
    antibodies-online proteins for CXCL2 (101 products) 

     
    antibodies-online peptides for CXCL2

    CXCL2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals CXCL2 Antibodies
    Abcam antibodies for CXCL2
    Browse Antibodies at Cloud-Clone Corp.
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    antibodies-online antibodies for CXCL2 (85 products) 

    CXCL2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CXCL2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CXCL2 
    antibodies-online kits for CXCL2 (48 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    3 InterPro protein domains:
     IPR001811 Chemokine_IL8-like_dom
     IPR001089 Chemokine_CXC
     IPR018048 Chemokine_CXC_CS

    Graphical View of Domain Structure for InterPro Entry P19875

    ProtoNet protein and cluster: P19875

    1 Blocks protein domain: IPB002473 Interleukin-8 signature

    UniProtKB/Swiss-Prot: CXCL2_HUMAN, P19875
    Similarity: Belongs to the intercrine alpha (chemokine CxC) family


    Find genes that share domains with CXCL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CXCL2_HUMAN, P19875
    Function: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory
    chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly
    enhanced hematopoietic activity

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18275857
    GO:0008009chemokine activity IEA--
         
    Find genes that share ontologies with CXCL2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CXCL2:
     Decreased focal adhesion (FA)   Increased G1 DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CXCL2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CXCL2:
    hsa-mir-1 (MIRT023893), hsa-mir-98-5p (MIRT027726), hsa-mir-335-5p (MIRT018317)

    Block miRNA regulation of human, mouse, rat CXCL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CXCL2 (see all 11):
    hsa-miR-3163 hsa-miR-607 hsa-miR-409-3p hsa-miR-128 hsa-miR-3681* hsa-miR-3617 hsa-miR-421 hsa-miR-641
    SwitchGear 3'UTR luciferase reporter plasmidCXCL2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CXCL2
    Predesigned siRNA for gene silencing in human, mouse, rat CXCL2

    Gene Editing
    Products:
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    Clone
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    OriGene clones in human, mouse for CXCL2 (see all 7)
    OriGene ORF clones in mouse, rat for CXCL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CXCL2 (NM_002089)
    Sino Biological Human cDNA Clone for CXCL2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CXCL2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CXCL2_HUMAN, P19875: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with CXCL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CXCL2 About   (see all 16)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    IL-6 Pathway0.61
    MIF Mediated Glucocorticoid Regulation0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43
    2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine receptors bind chemokines0.81
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    3Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    4Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.44
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with CXCL2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CXCL2
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CXCL2 (see all 17)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    MIF Mediated Glucocorticoid Regulation

    2 BioSystems Pathways for CXCL2
        Cytokines and Inflammatory Response
    Spinal Cord Injury


    2 Reactome Pathways for CXCL2
        Chemokine receptors bind chemokines
    G alpha (i) signalling events


    Selected Kegg Pathways  (Kegg details for CXCL2) (see all 7):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    NF-kappa B signaling pathway
    NOD-like receptor signaling pathway
    TNF signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CXCL2 (see all 20): 
              Neurogenesis in human mouse rat
              Wound Healing in human mouse rat
              Inflammasomes in human mouse rat
              Notch Signaling Targets in human mouse rat
              Th17 Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CXCL2

    Selected Interacting proteins for CXCL2 (P198751, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DPP4P274871, 2, 3EBI-2114901,EBI-2871277 MINT-8091061 I2D: score=1 
    CXCR2P250253I2D: score=3 
    CXCR1P250243I2D: score=2 
    MMP12P399003I2D: score=2 
    ELOF1P600023I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002237response to molecule of bacterial origin IDA19912257
    GO:0006935chemotaxis TAS2643119
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0060326cell chemotaxis TAS9873037

    Find genes that share ontologies with CXCL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CXCL2

    UniProtKB/Swiss-Prot: CXCL2_HUMAN, P19875
    Pharmaceutical: GRO-beta(5-73) is available under the name Garnocestim as immunomodulator. It is used prior to
    hematopoietic transplantation for peripheral blood stem cell mobilization and reduction of incidence, duration,
    and/or severity of chemotherapy induced cytopenias

    Selected Novoseek inferred chemical compound relationships for CXCL2 gene (see all 41)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    grobeta 92.1 37 8702798 (5), 16540656 (4), 15292528 (3), 19435811 (2) (see all 13)
    grogamma 91.3 15 8702798 (5), 15832427 (2), 9553055 (2), 10695618 (1) (see all 8)
    groalpha 81.6 12 8702798 (2), 16540656 (2), 10695618 (1), 19435811 (1) (see all 9)
    rantes 73.5 41 10505748 (3), 17015748 (3), 7682242 (2), 10531235 (2) (see all 28)
    ccl3 68.7 10 15585879 (2), 14734774 (1), 16552065 (1), 19067439 (1) (see all 8)
    tmtu 59.2 2 9726445 (1), 9707512 (1)
    tarc 46.1 4 15941911 (2), 20308302 (1), 11001915 (1)
    endotoxin 42.5 4 11705739 (2), 14504103 (1), 10768990 (1)
    ccl4 29.5 7 14734774 (1), 19120450 (1), 16552065 (1), 18340639 (1) (see all 6)
    8-oxo-dg 24.9 1 15337697 (1)



    Find genes that share compounds with CXCL2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CXCL2 gene: 
    NM_002089.3  

    Unigene Cluster for CXCL2:

    Chemokine (C-X-C motif) ligand 2
    Hs.75765  [show with all ESTs]
    Unigene Representative Sequence: NM_002089
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508487(uc003hhm.4) ENST00000296031 ENST00000510048
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CXCL2 (see all 11):
    hsa-miR-3163 hsa-miR-607 hsa-miR-409-3p hsa-miR-128 hsa-miR-3681* hsa-miR-3617 hsa-miR-421 hsa-miR-641
    SwitchGear 3'UTR luciferase reporter plasmidCXCL2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: CXCL2 (NM_002089)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat CXCL2
      QuantiFast Probe-based Assays in human, mouse, rat CXCL2

    Additional mRNA sequence: 

    AF043340.1 AK308504.1 AK311304.1 BC015753.1 CR542171.1 M36820.1 M57731.1 X53799.1 

    10 DOTS entries:

    DT.40314945  DT.40313580  DT.101968867  DT.121273395  DT.100786999  DT.95299876  DT.92445243  DT.95299860 
    DT.100786997  DT.101987218 

    Selected AceView cDNA sequences (see all 122):

    BM923815 AA362186 CR542171 CR601860 CA865685 CD367441 CR602080 AW103962 
    CA865443 BM772327 BM768469 CR617096 BM749667 BM761152 BX397603 BM763035 
    CD240332 BM820337 X53799 BM756509 C02042 CA309975 AA487664 BF847972 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CXCL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGAAGCTTT
    CXCL2 Expression
    About this image


    CXCL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
     
     Pancreas (Endocrine System)
             Duct Cells Pancreatic Ducts
     
     Adipose (Muscoskeletal System)
             Visceral White Adipose
     
     Blood (Cardiovascular System)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
    CXCL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CXCL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.75765
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CXCL2 (see all 20): 
              Neurogenesis in human mouse rat
              Wound Healing in human mouse rat
              Inflammasomes in human mouse rat
              Notch Signaling Targets in human mouse rat
              Th17 Response in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for CXCL2
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    QuantiTect SYBR Green Assays in human, mouse, rat CXCL2
    QuantiFast Probe-based Assays in human, mouse, rat CXCL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for CXCL2 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cxcl25
    Cxcl11
    chemokine (C-X-C motif) ligand 25
    chemokine (C-X-C motif) ligand 11
    78.67(n)1
    72(a)1
      5 (44.78 cM)5
    148251  NM_008176.31  NP_032202.11 
     909038995 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    38(a)
    1 → many
    4(50379773-50381069)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    39(a)
    1 → many
    6(60123888-60134622)


    ENSEMBL Gene Tree for CXCL2 (if available)
    TreeFam Gene Tree for CXCL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for CXCL2 gene
    PPBP2  PF42  CXCL12  PF4V12  CXCL62  CXCL32  CXCL52  IL82  
    13 SIMAP similar genes for CXCL2 using alignment to 1 protein entry:     CXCL2_HUMAN:
    CXCL3    CXCL1    PPBP    CXCL9    CXCL5    CXCL6
    CXCL10    PF4    PF4V1    IL8    CXCL11    CXCL12
    CXCL14

    Find genes that share paralogs with CXCL2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for CXCL2 (see all 179)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1449677661,2
    --74962269(+) TGTAAC/GCTGTT 1 -- ds50010--------
    rs1877215911,2
    --74962527(+) TATCAC/GTGATT 1 -- ds50010--------
    rs1490538851,2
    --74962615(+) ACCACA/GTGAAA 1 -- ds50010--------
    rs1923842001,2
    --74962642(+) GTTTAC/TCTGTA 1 -- ds50010--------
    rs1855752411,2
    C--74962698(+) GTAAAA/TCATCA 1 -- ds50010--------
    rs1152117581,2
    --74962767(+) TTAAAA/TATTTT 1 -- ut310--------
    rs91311,2
    C,F,O,A,H--74963049(-) CCAGTA/GAGATC 1 -- ut31 ese335Minor allele frequency- N:0.00MN EA NA NS WA 3727
    rs1433677141,2
    C--74963072(+) ATTCCC/TCAGCC 1 -- ut310--------
    rs1512973311,2
    C--74963209(+) CTAAAA/GTAAAC 1 -- ut310--------
    rs339504861,2
    C--74963303(+) CAAAC-/A/A   
       AAT
    /T
    TAAAT
    3 -- ut310--------

    HapMap Linkage Disequilibrium report for CXCL2 (74962752 - 74965010 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CXCL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv525980CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CXCL2
    DNA2.0 Custom Variant and Variant Library Synthesis for CXCL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 139110    OMIM disorders: --

    7 diseases for CXCL2:    
    About MalaCards
    acanthamoeba keratitis    stachybotrys chartarum    arthus reaction    stenotrophomonas maltophilia
    nephrogenic systemic fibrosis    extrinsic allergic alveolitis    sepsis


    Find genes that share disorders with CXCL2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CXCL2 gene (see all 33)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 65 23 19515386 (2), 11292716 (1), 11303726 (1), 10453028 (1) (see all 18)
    bronchoalveolar lavage fluid 63 13 16046875 (1), 10358192 (1), 16424224 (1), 16002559 (1) (see all 12)
    necrosis 58 56 2104219 (1), 18266468 (1), 20012648 (1), 14507887 (1) (see all 53)
    pneumonia 53.2 2 15320896 (1), 19522764 (1)
    pulmonary infection 41.3 1 10768990 (1)
    sepsis 41.3 12 17944017 (3), 15614130 (2), 11373406 (1), 19184349 (1) (see all 7)
    tumors 35.1 70 16424980 (4), 17561115 (4), 7927176 (2), 2104219 (1) (see all 51)
    peritonitis 32.1 7 15614130 (2), 11231849 (2), 11755216 (2), 11303726 (1)
    histopathology 30 2 19815632 (1), 11705739 (1)
    keratitis 24.7 6 12565810 (3)

    Genetic Association Database (GAD): CXCL2
    Human Genome Epidemiology (HuGE) Navigator: CXCL2 (9 documents)

    Export disorders for CXCL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CXCL2 gene, integrated from 10 sources (see all 416):
    (articles sorted by number of sources associating them with CXCL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of three related human GRO genes encoding cytokine functions. (PubMed id 2217207)1, 2, 3, 9 Haskill S.... Sager R. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    2. Identification of unique truncated KC/GRO beta chemokines with potent hematopoietic and anti-infective activities. (PubMed id 10725737)1, 2, 9 King A.G....Pelus L.M. (J. Immunol. 2000)
    3. A CXCL2 polymorphism is associated with better outcomes in patients with severe sepsis. (PubMed id 17944017)1, 4, 9 Villar J....Kacmarek R.M. (Crit. Care Med. 2007)
    4. Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues. (PubMed id 2201751)1, 2, 9 Tekamp-Olson P.... Cerami A. (J. Exp. Med. 1990)
    5. Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue. (PubMed id 2078213)1, 2, 9 Iida N. and Grotendorst G.R. (Mol. Cell. Biol. 1990)
    6. Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT). (PubMed id 21738479)1, 4 Reiner A.P....Wilson J.G. (PLoS Genet. 2011)
    7. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    8. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
    9. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)
    10. A CXCL2 tandem repeat promoter polymorphism is associated with susceptibility to severe sepsis in the Spanish population. (PubMed id 16421598)1, 4 Flores C.... . (Genes Immun. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2920 HGNC: 4603 AceView: CXCL2 Ensembl:ENSG00000081041 euGenes: HUgn2920
    ECgene: CXCL2 Kegg: 2920 H-InvDB: CXCL2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CXCL2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CXCL2 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CXCL2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CXCL2 gene:
    Search GeneIP for patents involving CXCL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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