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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CXCL2 Gene

protein-coding GIFtS: 57
GCID: GC04M074962

chemokine (C-X-C motif) ligand 2

(Previous name: GRO2 oncogene )
(Previous symbol: GRO2)

Explore 56 diseases affiliated with
CXCL2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chemokine (C-X-C Motif) Ligand 2¹ ²		Macrophage Inflammatory Protein 2-Alpha² ³
GRO2¹ ² ³ ⁵		MIP2-Alpha¹
SCYB2¹ ² ³		MIP2²
MIP2A² ³ ⁵		C-X-C Motif Chemokine 2²
CINC-2a¹ ²		Gro-Beta¹
GROb¹ ²		Melanoma Growth Stimulatory Activity Beta²
MGSA-B¹		MGSA Beta²
MIP-2a¹ ²		GROB³
GRO2 Oncogene¹ ²		Gro-Beta¹
Growth-Regulated Protein Beta² ³

External Ids:	HGNC: 4603¹	Entrez Gene: 2920²	Ensembl: ENSG00000081041⁷	OMIM: 139110⁵	UniProtKB: P19875³

Export aliases for CXCL2 gene to outside databases

Previous GC identifers: GC04M074951 GC04M075202 GC04M075363 GC04M075429 GC04M075329 GC04M070774

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CXCL2_HUMAN, P19875

Function: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory

chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly

enhanced hematopoietic activity

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_022778.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CXCL2 gene promoter:
TBP PPAR-gamma1 AML1a TFIID PPAR-gamma2 NF-E2 C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CXCL2 promoter sequence

Search SABiosciences Chromatin IP Primers for CXCL2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCL2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21 Ensembl cytogenetic band: 4q13.3 HGNC cytogenetic band: 4q13.3

CXCL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCL2 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M074962: view genomic region (about GC identifiers)

Start:	74,962,752 bp from pter	End:	74,965,010 bp from pter
Size:	2,259 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CXCL2_HUMAN, P19875 (See protein sequence)

Recommended Name: C-X-C motif chemokine 2 precursor

Size: 107 amino acids; 11389 Da

Subcellular location: Secreted

1 PDB 3D structure from and Proteopedia for CXCL2:

1QNK (3D)

Secondary accessions: Q6FGD6 Q9UPB8

Explore the universe of human proteins at neXtProt for CXCL2: NX_P19875

Post-translational modifications:

The N-terminal processed form GRO-beta(5-73) is produced by proteolytic cleavage after secretion from bone marrow

stromal cells¹

View neXtProt modification sites for NX_P19875

CXCL2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002080.1

ENSEMBL proteins:

ENSP00000427279

Reactome Protein details: P19875
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CXCL2 (CXCL2/GRO beta/MIP-2/CINC-3)
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	OriGene Purified Protein: CXCL2 OriGene Protein Over-expression Lysate: CXCL2 OriGene Custom Protein Services for CXCL2
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	Novus Biologicals CXCL2 Proteins Novus Biologicals CXCL2 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CXCL2
	Uscn Proteins for CXCL2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0005625	soluble fraction	--	--

CXCL2 for ontologies About GeneDecksing

CXCL2 Antibody Products:

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	Search for Antibodies for CXCL2 at Abcam
	Uscn Antibodies for CXCL2
	ThermoFisher Antibodies for CXCL2

Assay Products for CXCL2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for CXCL2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CXCL2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CXCL2 for domains About GeneDecksing

3 InterPro domains/families:

IPR001811 Chemokine_IL8-like_dom

IPR001089 Chemokine_CXC

IPR018048 Chemokine_CXC_CS

Graphical View of Domain Structure for InterPro Entry P19875

ProtoNet protein and cluster: P19875

1 Blocks protein family: IPB002473 Interleukin-8 signature

UniProtKB/Swiss-Prot: CXCL2_HUMAN, P19875

Similarity: Belongs to the intercrine alpha (chemokine CxC) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CXCL2_HUMAN, P19875

Function: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory

chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly

enhanced hematopoietic activity

miRNA Products:		OriGene 3'-UTR Clone: CXCL2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCL2
		8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL2 (see all 11):
		hsa-miR-3163 hsa-miR-607 hsa-miR-409-3p hsa-miR-128 hsa-miR-3681* hsa-miR-3617 hsa-miR-421 hsa-miR-641

		SwitchGear 3'UTR luciferase reporter plasmid: CXCL2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXCL2 (see all 7) OriGene shRNA RFP: CXCL2 OriGene siRNA: CXCL2
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CXCL2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CXCL2 (NM_002089)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CXCL2
		Search LifeMap BioReagents cell lines for CXCL2

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CXCL2

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008009	chemokine activity	IEA	--

CXCL2 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for CXCL2:

Decreased focal adhesion (FA)

Increased G1 DNA content

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PEDF Induced Signaling

8/9 pathways (see all 9)
PEDF Induced Signaling	1.00	RAR-Gamma-RXR-Alpha Degradation	0.54
MIF Mediated Glucocorticoid Regulation	0.73	STAT3 Pathway	0.47
MIF Regulation of Innate Immune Cells	0.71	Endothelin-1 Signaling Pathway	0.44
IL-6 Pathway	0.61	Cytokine-cytokine receptor interaction	0.26

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			Peptide ligand-binding receptors	0.61
	GPCR ligand binding	0.75			G alpha (i) signalling events	0.44

Rho Family GTPases

	Rho Family GTPases	1.00			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

PAK Pathway

PAK Pathway

1.00

Antioxidant Action of Vitamin-C

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CXCL2 (see all 17)

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	Transendothelial Migration of Leukocytes
	MIF Mediated Glucocorticoid Regulation

1 BioSystems Pathway for CXCL2

Cytokines and Inflammatory Response

5/8 Reactome Pathways for CXCL2 (see all 8)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Chemokine receptors bind chemokines
	Signal Transduction
	Signaling by GPCR

3 Kegg Pathways (Kegg details for CXCL2):

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway
	NOD-like receptor signaling pathway

CXCL2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CXCL2

5/14 Interacting proteins for CXCL2 (P19875^{2, 3}) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DPP4	P27487²^,³	MINT-8091061 I2D: score=1
CXCR2	P25025³	I2D: score=3
CXCR1	P25024³	I2D: score=2
MMP12	P39900³	I2D: score=2
ELOF1	P60002³	I2D: score=1

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002237	response to molecule of bacterial origin	IDA	19912257
GO:0006935	chemotaxis	IEA	--
GO:0006954	inflammatory response	IEA	--
GO:0006955	immune response	IEA	--

CXCL2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CXCL2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CXCL2
UniProtKB/Swiss-Prot: CXCL2_HUMAN, P19875

Pharmaceutical: GRO-beta(5-73) is available under the name Garnocestim as immunomodulator. It is used prior to

hematopoietic transplantation for peripheral blood stem cell mobilization and reduction of incidence, duration, and/or

severity of chemotherapy induced cytopenias

10/41 Novoseek chemical compound relationships for CXCL2 gene (see all 41) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
grobeta	92.1	37	8702798 (5), 16540656 (4), 15292528 (3), 19435811 (2) (see all 13)
grogamma	91.3	15	8702798 (5), 15832427 (2), 9553055 (2), 10695618 (1) (see all 8)
groalpha	81.6	12	8702798 (2), 16540656 (2), 10695618 (1), 19435811 (1) (see all 9)
rantes	73.5	41	10505748 (3), 17015748 (3), 7682242 (2), 10531235 (2) (see all 28)
ccl3	68.7	10	15585879 (2), 14734774 (1), 16552065 (1), 19067439 (1) (see all 8)
tmtu	59.2	2	9726445 (1), 9707512 (1)
tarc	46.1	4	15941911 (2), 20308302 (1), 11001915 (1)
endotoxin	42.5	4	11705739 (2), 14504103 (1), 10768990 (1)
ccl4	29.5	7	14734774 (1), 19120450 (1), 16552065 (1), 18340639 (1) (see all 6)
8-oxo-dg	24.9	1	15337697 (1)

Search CenterWatch for drugs/clinical trials and news about CXCL2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CXCL2 gene:

NM_002089.3

Unigene Cluster for CXCL2:

Chemokine (C-X-C motif) ligand 2

Hs.75765 [show with all ESTs]

Unigene Representative Sequence: NM_002089

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000508487(uc003hhm.4) ENST00000296031 ENST00000510048

miRNA Products:		OriGene 3'-UTR Clone: CXCL2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCL2
		8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL2 (see all 11):
		hsa-miR-3163 hsa-miR-607 hsa-miR-409-3p hsa-miR-128 hsa-miR-3681* hsa-miR-3617 hsa-miR-421 hsa-miR-641

		SwitchGear 3'UTR luciferase reporter plasmid: CXCL2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXCL2 (see all 7) OriGene shRNA RFP: CXCL2 OriGene siRNA: CXCL2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCL2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CXCL2 (NM_002089)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL2

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXCL2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL2

Additional cDNA sequence:

AF043340.1 AK308504.1 AK311304.1 BC015753.1 CR542171.1 M36820.1 M57731.1 X53799.1

10 DOTS entries:

DT.40314945 DT.40313580 DT.101968867 DT.121273395 DT.100786999 DT.95299876 DT.92445243 DT.95299860

DT.100786997 DT.101987218

24/122 AceView cDNA sequences (see all 122):

CR601860 BM763035 AW103962 BM820337 AA487664 X53799 BM768469 CD367441

CR617096 CD240332 BM756509 CA865443 BM772327 CR542171 CR602080 BF847972

BX397603 BM761152 CA309975 CA865685 BM923815 C02042 BM749667 BM771156

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CXCL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGAAGCTTT

About this image

CXCL2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Myocardium

Cardiac Fibroblasts

Epicardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

See CXCL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CXCL2

SOURCE GeneReport for Unigene cluster: Hs.75765

SABiosciences Expression via Pathway-Focused PCR Arrays including CXCL2 (see all 20):

Neurogenesis in human mouse rat

Wound Healing in human mouse rat

Inflammasomes in human mouse rat

Notch Signaling Targets in human mouse rat

Th17 Response in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CXCL2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CXCL2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXCL2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL2

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CXCL2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CXCL2 gene from 2/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cxcl2⁵ Cxcl1¹	chemokine (C-X-C motif) ligand 2⁵ chemokine (C-X-C motif) ligand 1¹	77.04(n)¹ 70(a)¹		5 (44.78 cM)⁵ 14825¹ NM_008176.3¹ NP_032202.1¹ 90903899⁵
chicken (Gallus gallus)	Aves	--	Uncharacterized protein	38(a)	1 → many	4(52472071-52473367)

ENSEMBL Gene Tree for CXCL2 (if available)
TreeFam Gene Tree for CXCL2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CXCL2 gene

CXCL3² PPBP² PF4² CXCL5² CXCL1² PF4V1² IL8² CXCL6²

13 SIMAP similar genes for CXCL2 using alignment to 1 protein entry: CXCL2_HUMAN:

CXCL3 CXCL1 PPBP CXCL9 CXCL5 CXCL6

CXCL10 PF4 PF4V1 IL8 CXCL11 CXCL12

CXCL14

CXCL2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CXCL2

DNA2.0 Custom Variant and Variant Library Synthesis for CXCL2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CXCL2 for disorders           About GeneDecksing

OMIM gene information: 139110    OMIM disorders: --

20/56 diseases for CXCL2 (see all 56):    About MalaCards

glycogen storage disease type ia extrinsic allergic alveolitis stachybotrys chartarum human monocytic ehrlichiosis

glycogen storage disease arthus reaction clostridium difficile surfactant deficiency

melanoma keratitis atrial fibrillation esophageal squamous cell carcinoma

squamous cell carcinoma autoimmune myocarditis inflammatory bowel disease sickle cell disease

brain injury ehrlichiosis meningoencephalitis ulcerative colitis

1 disease from the University of Copenhagen DISEASES database for CXCL2:

Human monocytic ehrlichiosis

10/33 Novoseek disease relationships for CXCL2 gene (see all 33) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	65	23	19515386 (2), 11292716 (1), 11303726 (1), 10453028 (1) (see all 18)
bronchoalveolar lavage fluid	63	13	16046875 (1), 10358192 (1), 16424224 (1), 16002559 (1) (see all 12)
necrosis	58	56	2104219 (1), 18266468 (1), 20012648 (1), 14507887 (1) (see all 53)
pneumonia	53.2	2	15320896 (1), 19522764 (1)
pulmonary infection	41.3	1	10768990 (1)
sepsis	41.3	12	17944017 (3), 15614130 (2), 11373406 (1), 19184349 (1) (see all 7)
tumors	35.1	70	16424980 (4), 17561115 (4), 7927176 (2), 2104219 (1) (see all 51)
peritonitis	32.1	7	15614130 (2), 11231849 (2), 11755216 (2), 11303726 (1)
histopathology	30	2	19815632 (1), 11705739 (1)
keratitis	24.7	6	12565810 (3)

Human Genome Epidemiology (HuGE) Navigator: CXCL2 (9 documents)

Export disorders for CXCL2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CXCL2 gene, integrated from 9 sources (see all 407):
(articles sorted by number of sources associating them with CXCL2)

Utopia: connect your pdf to the dynamic
world of online information

Identification of three related human GRO genes encoding cytokine functions. (PubMed id 2217207)^{1, 2, 3, 9} Haskill S.... Sager R. (1990)
Identification of unique truncated KC/GRO beta chemokines with potent hematopoietic and anti-infective activities. (PubMed id 10725737)^{1, 2, 9} King A.G....Pelus L.M. (2000)
Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues. (PubMed id 2201751)^{1, 2, 9} Tekamp-Olson P.... Cerami A. (1990)
Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue. (PubMed id 2078213)^{1, 2, 9} Iida N. and Grotendorst G.R. (1990)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Nuclear magnetic resonance solution structure of truncated human GRObeta [5-73] and its structural comparison with CXC chemokine family members GROalpha and IL-8. (PubMed id 10600366)^{1, 2} Qian Y.Q.... McDevitt P. (1999)
Monocyte adherence results in selective induction of novel genes sharing homology with mediators of inflammation and tissue repair. (PubMed id 2341726)^{1, 2} Sporn S.A.... Haskill S. (1990)
Functional and receptor binding characterization of recombinant murine macrophage inflammatory protein 2: sequence analysis and mutagenesis identify receptor binding epitopes. (PubMed id 9260277)^{1, 9} Jerva L.F....Lolis E. (1997)
Expression of growth-regulated oncogene beta in an endometrial epithelial cell line, HHUA, and cultured human endometrial cells. (PubMed id 12892904)^{1, 9} Fukuda J....Miyakawa I. (2003)
The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor. (PubMed id 8702798)^{1, 9} Ahuja S.K. and Murphy P.M. (1996)

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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2920	HGNC: 4603	AceView: CXCL2	Ensembl:ENSG00000081041	euGenes: HUgn2920
ECgene: CXCL2	Kegg: 2920	H-InvDB: CXCL2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CXCL2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CXCL2	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/CXCL2

Intellectual Property for CXCL2 gene
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Patent Information for CXCL2 gene:
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CXCL2 Gene

chemokine (C-X-C motif) ligand 2

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CXCL2 (Gene Symbol)
Chemokine (C-X-C Motif) Ligand 2
GRO2
SCYB2
MIP2A
CINC-2a
GROb
MGSA-B
MIP-2a
GRO2 Oncogene
Growth-Regulated Protein Beta
Macrophage Inflammatory Protein 2-Alpha
MIP2-Alpha
MIP2
C-X-C Motif Chemokine 2
Gro-Beta
Melanoma Growth Stimulatory Activity Beta
MGSA Beta
GROB
Gro-Beta

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Osteoarthritis
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Leukemia
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Intoxication
Edema
cell damage
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Respiratory Tract Infections
Shock
Bronchoalveolar Lavage Fluid
Bleeding
Inflammation
Histopathology
Gastritis
aqueous humor
LIVER DAMAGE
Pneumonia
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Necrosis
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virus infection
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CXCL2 Gene

chemokine (C-X-C motif) ligand 2

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for CXCL2 gene

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for CXCL2 gene

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for CXCL2 gene

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