Aliases for CXCL2 Gene
External Ids for CXCL2 Gene
Previous HGNC Symbols for CXCL2 Gene
Previous GeneCards Identifiers for CXCL2 Gene
This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014]
GeneCards Summary for CXCL2 Gene
CXCL2 (C-X-C Motif Chemokine Ligand 2) is a Protein Coding gene. Diseases associated with CXCL2 include acanthamoeba keratitis and keratitis. Among its related pathways are Signaling by GPCR and ERK Signaling. GO annotations related to this gene include chemokine activity and CXCR chemokine receptor binding. An important paralog of this gene is PF4.
UniProtKB/Swiss-Prot for CXCL2 Gene
Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity.