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Aliases for CXCL2 Gene

Aliases for CXCL2 Gene

  • C-X-C Motif Chemokine Ligand 2 2 3
  • Chemokine (C-X-C Motif) Ligand 2 2 3 5
  • Macrophage Inflammatory Protein 2-Alpha 3 4
  • Growth-Regulated Protein Beta 3 4
  • GRO2 Oncogene 2 3
  • MIP2-Alpha 3 4
  • Gro-Beta 3 4
  • MIP2A 3 4
  • SCYB2 3 4
  • GROb 3 4
  • GRO2 3 4
  • Melanoma Growth Stimulatory Activity Beta 3
  • MGSA Beta 3
  • CINC-2a 3
  • MGSA-B 3
  • MIP-2a 3
  • MIP2 3

External Ids for CXCL2 Gene

Previous HGNC Symbols for CXCL2 Gene

  • GRO2

Previous GeneCards Identifiers for CXCL2 Gene

  • GC04M074951
  • GC04M075202
  • GC04M075363
  • GC04M075429
  • GC04M075329
  • GC04M074962
  • GC04M070774

Summaries for CXCL2 Gene

Entrez Gene Summary for CXCL2 Gene

  • This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014]

GeneCards Summary for CXCL2 Gene

CXCL2 (C-X-C Motif Chemokine Ligand 2) is a Protein Coding gene. Diseases associated with CXCL2 include Acanthamoeba Keratitis and Keratitis. Among its related pathways are Peptide ligand-binding receptors and TNF signaling pathway. GO annotations related to this gene include chemokine activity and CXCR chemokine receptor binding. An important paralog of this gene is PF4.

UniProtKB/Swiss-Prot for CXCL2 Gene

  • Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL2 Gene

Genomics for CXCL2 Gene

Regulatory Elements for CXCL2 Gene

Enhancers for CXCL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CXCL2 on UCSC Golden Path with GeneCards custom track

Promoters for CXCL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CXCL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CXCL2 Gene

74,097,035 bp from pter
74,099,293 bp from pter
2,259 bases
Minus strand

Genomic View for CXCL2 Gene

Genes around CXCL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL2 Gene

Proteins for CXCL2 Gene

  • Protein details for CXCL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-X-C motif chemokine 2
    Protein Accession:
    Secondary Accessions:
    • Q6FGD6
    • Q9UPB8

    Protein attributes for CXCL2 Gene

    107 amino acids
    Molecular mass:
    11389 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CXCL2 Gene

neXtProt entry for CXCL2 Gene

Proteomics data for CXCL2 Gene at MOPED

Post-translational modifications for CXCL2 Gene

  • The N-terminal processed form GRO-beta(5-73) is produced by proteolytic cleavage after secretion from bone marrow stromal cells.

Other Protein References for CXCL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CXCL2 (CXCL2/GRO beta/MIP-2/CINC-3)

No data available for DME Specific Peptides for CXCL2 Gene

Domains & Families for CXCL2 Gene

Gene Families for CXCL2 Gene

Protein Domains for CXCL2 Gene

Suggested Antigen Peptide Sequences for CXCL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intercrine alpha (chemokine CxC) family.
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL2: view

Function for CXCL2 Gene

Molecular function for CXCL2 Gene

UniProtKB/Swiss-Prot Function:
Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity.
genes like me logo Genes that share phenotypes with CXCL2: view

Animal Models for CXCL2 Gene

MGI Knock Outs for CXCL2:

Animal Model Products

miRNA for CXCL2 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CXCL2 Gene

Localization for CXCL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL2 Gene


Subcellular locations from

Jensen Localization Image for CXCL2 Gene COMPARTMENTS Subcellular localization image for CXCL2 gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 1
lysosome 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CXCL2 Gene

Pathways & Interactions for CXCL2 Gene

genes like me logo Genes that share pathways with CXCL2: view

Gene Ontology (GO) - Biological Process for CXCL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis TAS 2643119
GO:0006955 immune response IEA,IBA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0032496 response to lipopolysaccharide IBA --
GO:0042127 regulation of cell proliferation IBA --
genes like me logo Genes that share ontologies with CXCL2: view

No data available for SIGNOR curated interactions for CXCL2 Gene

Drugs & Compounds for CXCL2 Gene

(18) Drugs for CXCL2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(23) Additional Compounds for CXCL2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CXCL2: view

Transcripts for CXCL2 Gene

mRNA/cDNA for CXCL2 Gene

Unigene Clusters for CXCL2 Gene

Chemokine (C-X-C motif) ligand 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL2 Gene

No ASD Table

Relevant External Links for CXCL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CXCL2 Gene

mRNA expression in normal human tissues for CXCL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CXCL2 Gene

This gene is overexpressed in Liver (x19.8) and Lung (x4.3).

Protein differential expression in normal tissues from HIPED for CXCL2 Gene

This gene is overexpressed in Milk (38.2) and Platelet (27.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CXCL2 Gene

SOURCE GeneReport for Unigene cluster for CXCL2 Gene Hs.75765

genes like me logo Genes that share expression patterns with CXCL2: view

Protein tissue co-expression partners for CXCL2 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CXCL2 Gene

Orthologs for CXCL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CXCL2 35
  • 85.46 (n)
  • 82.98 (a)
-- 36
  • 82 (a)
CXCL3 36
  • 80 (a)
GRO1 36
  • 52 (a)
(Mus musculus)
Mammalia Cxcl1 35
  • 78.67 (n)
  • 72 (a)
Cxcl1 16
Cxcl1 36
  • 65 (a)
(Pan troglodytes)
Mammalia CXCL2 35
  • 98.44 (n)
  • 96.26 (a)
CXCL2 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Cxcl1 35
  • 79.11 (n)
  • 73.33 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 42 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
-- 36
  • 38 (a)
-- 36
  • 54 (a)
-- 36
  • 52 (a)
(Gallus gallus)
Aves -- 36
  • 38 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 39 (a)
Species with no ortholog for CXCL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL2 Gene

Gene Tree for CXCL2 (if available)
Gene Tree for CXCL2 (if available)

Paralogs for CXCL2 Gene

Paralogs for CXCL2 Gene

(13) SIMAP similar genes for CXCL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CXCL2: view

Variants for CXCL2 Gene

Sequence variations from dbSNP and Humsavar for CXCL2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs9131 -- 74,097,332(-) CCAGT(A/G)AGATC utr-variant-3-prime
rs1049806 -- 74,097,653(-) CCTGG(A/C)TTGCG utr-variant-3-prime
rs1837558 -- 74,097,867(-) ATTCA(A/G)AAAAC intron-variant
rs3806792 -- 74,099,557(+) CATCC(C/T)TACCG upstream-variant-2KB
rs5859414 -- 74,097,601(+) ATAAA(-/ATAA)TAAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CXCL2 Gene

Variant ID Type Subtype PubMed ID
nsv525980 CNV Gain 19592680

Variation tolerance for CXCL2 Gene

Residual Variation Intolerance Score: 61.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.77% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CXCL2 Gene

Disorders for CXCL2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CXCL2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acanthamoeba keratitis
  • keratitis, hereditary
stachybotrys chartarum
  • stachybotrys atra
demyelinating disease
  • demyelinating disorder
nephrogenic systemic fibrosis
  • nephrogenic fibrosing dermopathy
- elite association - COSMIC cancer census association via MalaCards
Search CXCL2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CXCL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CXCL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL2 Gene

Publications for CXCL2 Gene

  1. Identification of three related human GRO genes encoding cytokine functions. (PMID: 2217207) Haskill S. … Sager R. (Proc. Natl. Acad. Sci. U.S.A. 1990) 2 3 4 67
  2. A key role for early growth response-1 and nuclear factor-kappaB in mediating and maintaining GRO/CXCR2 proliferative signaling in esophageal cancer. (PMID: 19435811) Wang B. … Hendricks D.T. (Mol. Cancer Res. 2009) 3 23
  3. A CXCL2 polymorphism is associated with better outcomes in patients with severe sepsis. (PMID: 17944017) Villar J. … Kacmarek R.M. (Crit. Care Med. 2007) 3 23
  4. Neutrophil elastase, MIP-2, and TLR-4 expression during human and experimental sepsis. (PMID: 15614130) Tsujimoto H. … Mochizuki H. (Shock 2005) 3 23
  5. Expression of growth-regulated oncogene beta in an endometrial epithelial cell line, HHUA, and cultured human endometrial cells. (PMID: 12892904) Fukuda J. … Miyakawa I. (J. Reprod. Immunol. 2003) 3 23

Products for CXCL2 Gene

Sources for CXCL2 Gene