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Aliases for CXCL17 Gene

Aliases for CXCL17 Gene

  • Chemokine (C-X-C Motif) Ligand 17 2 3
  • VCC1 3 4 6
  • DMC 3 4 6
  • Dendritic Cell And Monocyte Chemokine-Like Protein 3 4
  • C-X-C Motif Chemokine 17 3 4
  • VEGF Co-Regulated Chemokine 1 3
  • VEGF Coregulated Chemokine 1 3
  • UNQ473 3
  • Dcip1 3
  • VCC-1 3

External Ids for CXCL17 Gene

Summaries for CXCL17 Gene

GeneCards Summary for CXCL17 Gene

CXCL17 (Chemokine (C-X-C Motif) Ligand 17) is a Protein Coding gene. Among its related pathways are Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions.

UniProtKB/Swiss-Prot for CXCL17 Gene

  • Plays a role in angiogenesis and possibly in the development of tumors. May be a housekeeping chemokine regulating recruitment of nonactivated blood monocytes and immature dendritic cells into tissues. May play a role in the innate defense against infections.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL17 Gene

Genomics for CXCL17 Gene

Genomic Location for CXCL17 Gene

Start:
42,428,288 bp from pter
End:
42,443,048 bp from pter
Size:
14,761 bases
Orientation:
Minus strand

Genomic View for CXCL17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CXCL17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL17 Gene

Regulatory Elements for CXCL17 Gene

Proteins for CXCL17 Gene

  • Protein details for CXCL17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXB2-VCC1_HUMAN
    Recommended name:
    VEGF coregulated chemokine 1
    Protein Accession:
    Q6UXB2
    Secondary Accessions:
    • A8KAC0

    Protein attributes for CXCL17 Gene

    Size:
    119 amino acids
    Molecular mass:
    13819 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CXCL17 Gene

Proteomics data for CXCL17 Gene at MOPED

Post-translational modifications for CXCL17 Gene

No Post-translational modifications

Other Protein References for CXCL17 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CXCL17 Gene

Domains for CXCL17 Gene

Protein Domains for CXCL17 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

VCC1_HUMAN
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.:
    • Q6UXB2
genes like me logo Genes that share domains with CXCL17: view

No data available for Gene Families for CXCL17 Gene

Function for CXCL17 Gene

Molecular function for CXCL17 Gene

UniProtKB/Swiss-Prot Function: Plays a role in angiogenesis and possibly in the development of tumors. May be a housekeeping chemokine regulating recruitment of nonactivated blood monocytes and immature dendritic cells into tissues. May play a role in the innate defense against infections.
UniProtKB/Swiss-Prot Induction: Found to be up-regulated in duodenal mucosa during acute cholera.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CXCL17 Gene

Localization for CXCL17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL17 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CXCL17 Gene COMPARTMENTS Subcellular localization image for CXCL17 gene
Compartment Confidence
extracellular 5
lysosome 1

Gene Ontology (GO) - Cellular Components for CXCL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with CXCL17: view

Pathways for CXCL17 Gene

genes like me logo Genes that share pathways with CXCL17: view

Pathways by source for CXCL17 Gene

Interacting Proteins for CXCL17 Gene

Gene Ontology (GO) - Biological Process for CXCL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006935 chemotaxis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with CXCL17: view

Transcripts for CXCL17 Gene

mRNA/cDNA for CXCL17 Gene

Unigene Clusters for CXCL17 Gene

Chemokine (C-X-C motif) ligand 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL17 Gene

No ASD Table

Relevant External Links for CXCL17 Gene

GeneLoc Exon Structure for
CXCL17
ECgene alternative splicing isoforms for
CXCL17

Expression for CXCL17 Gene

mRNA expression in normal human tissues for CXCL17 Gene

mRNA differential expression in normal tissues according to GTEx for CXCL17 Gene

This gene is overexpressed in Stomach (16.0), Minor Salivary Gland (11.6), Esophagus - Mucosa (9.8), and Lung (5.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CXCL17 Gene

SOURCE GeneReport for Unigene cluster for CXCL17 Gene Hs.445586

mRNA Expression by UniProt/SwissProt for CXCL17 Gene

Q6UXB2-VCC1_HUMAN
Tissue specificity: Detected in trachea, stomach, lung and skeletal muscle. Detected in intestine and in normal and asthmatic lung (at protein level). Breast tumors showed 3- to 24-fold up-regulation.
genes like me logo Genes that share expressions with CXCL17: view

Orthologs for CXCL17 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CXCL17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXCL17 36
  • 98.6 (n)
  • 98.32 (a)
CXCL17 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CXCL17 36
  • 84.42 (n)
  • 76.09 (a)
CXCL17 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CXCL17 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cxcl17 36
  • 80.33 (n)
  • 71 (a)
Cxcl17 16
Cxcl17 37
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cxcl17 36
  • 78 (n)
  • 65 (a)
Species with no ortholog for CXCL17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL17 Gene

ENSEMBL:
Gene Tree for CXCL17 (if available)
TreeFam:
Gene Tree for CXCL17 (if available)

Paralogs for CXCL17 Gene

No data available for Paralogs for CXCL17 Gene

Variants for CXCL17 Gene

Structural Variations from Database of Genomic Variants (DGV) for CXCL17 Gene

Variant ID Type Subtype PubMed ID
nsv526186 CNV Gain 19592680
esv2422471 CNV Deletion 17116639
dgv3886n71 CNV Gain 21882294
nsv911804 CNV Loss 21882294

Relevant External Links for CXCL17 Gene

HapMap Linkage Disequilibrium report
CXCL17

No data available for Sequence variations from dbSNP and Humsavar for CXCL17 Gene

Disorders for CXCL17 Gene

No disorders were found for CXCL17 Gene.

No data available for UniProtKB/Swiss-Prot for CXCL17 Gene

Publications for CXCL17 Gene

  1. VCC-1, a novel chemokine, promotes tumor growth. (PMID: 16989774) Weinstein E.J. … Mazzarella R. (Biochem. Biophys. Res. Commun. 2006) 3 4 23
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  4. Novel human dendritic cell- and monocyte-attracting chemokine-like protein identified by fold recognition methods. (PMID: 16455961) Pisabarro M.T. … Schmidt K.N. (J. Immunol. 2006) 3 4
  5. The chemokine and chemokine receptor superfamilies and their molecular evolution. (PMID: 17201934) Zlotnik A. … Nomiyama H. (Genome Biol. 2006) 2 3

Products for CXCL17 Gene

Sources for CXCL17 Gene

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