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Aliases for CXCL17 Gene

Aliases for CXCL17 Gene

  • C-X-C Motif Chemokine Ligand 17 2 3
  • Chemokine (C-X-C Motif) Ligand 17 2 3 5
  • Dendritic Cell And Monocyte Chemokine-Like Protein 3 4
  • C-X-C Motif Chemokine 17 3 4
  • VCC1 3 4
  • DMC 3 4
  • VEGF Co-Regulated Chemokine 1 3
  • UNQ473 3
  • Dcip1 3
  • VCC-1 3

External Ids for CXCL17 Gene

Previous GeneCards Identifiers for CXCL17 Gene

  • GC19M047625
  • GC19M042932
  • GC19M039362

Summaries for CXCL17 Gene

Entrez Gene Summary for CXCL17 Gene

  • The protein encoded by this gene is a mucosal chemokine that attracts immature dendritic cells and blood monocytes to the lungs. The encoded protein also promotes tumorigenesis through an angiogenic activity. Finally, this protein exhibits strong antimicrobial activity against E. coli, S. aureus, Salmonella, P. aeruginosa, and C. albicans. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for CXCL17 Gene

CXCL17 (C-X-C Motif Chemokine Ligand 17) is a Protein Coding gene. Among its related pathways are Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions.

UniProtKB/Swiss-Prot for CXCL17 Gene

  • Plays a role in angiogenesis and possibly in the development of tumors. May be a housekeeping chemokine regulating recruitment of nonactivated blood monocytes and immature dendritic cells into tissues. May play a role in the innate defense against infections.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL17 Gene

Genomics for CXCL17 Gene

Regulatory Elements for CXCL17 Gene

Genomic Location for CXCL17 Gene

Chromosome:
19
Start:
42,428,288 bp from pter
End:
42,443,048 bp from pter
Size:
14,761 bases
Orientation:
Minus strand

Genomic View for CXCL17 Gene

Genes around CXCL17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCL17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCL17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL17 Gene

Proteins for CXCL17 Gene

  • Protein details for CXCL17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXB2-VCC1_HUMAN
    Recommended name:
    VEGF coregulated chemokine 1
    Protein Accession:
    Q6UXB2
    Secondary Accessions:
    • A8KAC0

    Protein attributes for CXCL17 Gene

    Size:
    119 amino acids
    Molecular mass:
    13819 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CXCL17 Gene

Proteomics data for CXCL17 Gene at MOPED

Post-translational modifications for CXCL17 Gene

No Post-translational modifications

Other Protein References for CXCL17 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CXCL17 (CXCL17/VCC-1)

No data available for DME Specific Peptides for CXCL17 Gene

Domains & Families for CXCL17 Gene

Gene Families for CXCL17 Gene

Protein Domains for CXCL17 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CXCL17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UXB2

UniProtKB/Swiss-Prot:

VCC1_HUMAN :
  • Belongs to the intercrine alpha (chemokine CxC) family.
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL17: view

Function for CXCL17 Gene

Molecular function for CXCL17 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in angiogenesis and possibly in the development of tumors. May be a housekeeping chemokine regulating recruitment of nonactivated blood monocytes and immature dendritic cells into tissues. May play a role in the innate defense against infections.
UniProtKB/Swiss-Prot Induction:
Found to be up-regulated in duodenal mucosa during acute cholera.
genes like me logo Genes that share phenotypes with CXCL17: view

Animal Models for CXCL17 Gene

MGI Knock Outs for CXCL17:

Animal Model Products

  • Taconic Biosciences Mouse Models for CXCL17

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CXCL17 Gene

Localization for CXCL17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL17 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CXCL17 Gene COMPARTMENTS Subcellular localization image for CXCL17 gene
Compartment Confidence
extracellular 5
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CXCL17 Gene

Pathways & Interactions for CXCL17 Gene

genes like me logo Genes that share pathways with CXCL17: view

Pathways by source for CXCL17 Gene

Interacting Proteins for CXCL17 Gene

Gene Ontology (GO) - Biological Process for CXCL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
genes like me logo Genes that share ontologies with CXCL17: view

No data available for SIGNOR curated interactions for CXCL17 Gene

Drugs & Compounds for CXCL17 Gene

No Compound Related Data Available

Transcripts for CXCL17 Gene

mRNA/cDNA for CXCL17 Gene

Unigene Clusters for CXCL17 Gene

Chemokine (C-X-C motif) ligand 17:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL17 Gene

No ASD Table

Relevant External Links for CXCL17 Gene

GeneLoc Exon Structure for
CXCL17
ECgene alternative splicing isoforms for
CXCL17

Expression for CXCL17 Gene

mRNA expression in normal human tissues for CXCL17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CXCL17 Gene

This gene is overexpressed in Stomach (x16.0), Minor Salivary Gland (x11.6), Esophagus - Mucosa (x9.8), and Lung (x5.5).

Protein differential expression in normal tissues from HIPED for CXCL17 Gene

This gene is overexpressed in Lung (45.7) and Pancreas (23.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CXCL17 Gene



SOURCE GeneReport for Unigene cluster for CXCL17 Gene Hs.445586

mRNA Expression by UniProt/SwissProt for CXCL17 Gene

Q6UXB2-VCC1_HUMAN
Tissue specificity: Detected in trachea, stomach, lung and skeletal muscle. Detected in intestine and in normal and asthmatic lung (at protein level). Breast tumors showed 3- to 24-fold up-regulation.
genes like me logo Genes that share expression patterns with CXCL17: view

Protein tissue co-expression partners for CXCL17 Gene

Primer Products

In Situ Assay Products

Orthologs for CXCL17 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CXCL17 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CXCL17 35
  • 84.42 (n)
  • 76.09 (a)
CXCL17 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cxcl17 35
  • 80.33 (n)
  • 71 (a)
Cxcl17 16
Cxcl17 36
  • 52 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CXCL17 35
  • 98.6 (n)
  • 98.32 (a)
CXCL17 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cxcl17 35
  • 78 (n)
  • 65 (a)
dog
(Canis familiaris)
Mammalia CXCL17 36
  • 83 (a)
OneToOne
Species with no ortholog for CXCL17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL17 Gene

ENSEMBL:
Gene Tree for CXCL17 (if available)
TreeFam:
Gene Tree for CXCL17 (if available)

Paralogs for CXCL17 Gene

No data available for Paralogs for CXCL17 Gene

Variants for CXCL17 Gene

Structural Variations from Database of Genomic Variants (DGV) for CXCL17 Gene

Variant ID Type Subtype PubMed ID
nsv526186 CNV Gain 19592680
esv2422471 CNV Deletion 17116639
dgv3886n71 CNV Gain 21882294
nsv911804 CNV Loss 21882294

Variation tolerance for CXCL17 Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CXCL17 Gene

HapMap Linkage Disequilibrium report
CXCL17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for CXCL17 Gene

Disorders for CXCL17 Gene

Relevant External Links for CXCL17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CXCL17

No disorders were found for CXCL17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CXCL17 Gene

Publications for CXCL17 Gene

  1. VCC-1, a novel chemokine, promotes tumor growth. (PMID: 16989774) Weinstein E.J. … Mazzarella R. (Biochem. Biophys. Res. Commun. 2006) 3 4 23 67
  2. The chemokine and chemokine receptor superfamilies and their molecular evolution. (PMID: 17201934) Zlotnik A. … Nomiyama H. (Genome Biol. 2006) 2 3
  3. VCC-1 over-expression inhibits cisplatin-induced apoptosis in HepG2 cells. (PMID: 22425983) Zhou Z. … Li M. (Biochem. Biophys. Res. Commun. 2012) 3
  4. CXCL17 is a mucosal chemokine elevated in idiopathic pulmonary fibrosis that exhibits broad antimicrobial activity. (PMID: 22611239) Burkhardt A.M. … Zlotnik A. (J. Immunol. 2012) 3
  5. CXCL17 and ICAM2 are associated with a potential anti-tumor immune response in early intraepithelial stages of human pancreatic carcinogenesis. (PMID: 20955708) Hiraoka N. … Kanai Y. (Gastroenterology 2011) 3

Products for CXCL17 Gene

Sources for CXCL17 Gene

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