CXCL17 Gene
protein-coding GIFtS: 41
GCID: GC19M042932
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chemokine (C-X-C motif) ligand 17
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Aliases
for CXCL17 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chemokine (C-X-C Motif) Ligand 171 2 | | Dendritic Cell And Monocyte Chemokine-Like Protein2 3 | | DMC1 2 3 | | C-X-C Motif Chemokine 172 3 | | VCC11 2 3 | | VCC-12 | | Dcip11 2 | | VEGF Co-Regulated Chemokine 12 | | UNQ4731 2 | | |
Export aliases for CXCL17 gene to outside databasesPrevious GC identifers: GC19M047625 GC19M039362 |
Summaries
for CXCL17 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: VCC1_HUMAN, Q6UXB2Function: Plays a role in angiogenesis and possibly in the development of tumors. May be a housekeeping chemokineregulating recruitment of nonactivated blood monocytes and immature dendritic cells into tissues. May play a role inthe innate defense against infections
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Genomic Views
for CXCL17 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CXCL17 gene promoter:
COUP-TF1 COUP FOXD1 Tal-1beta AREB6 RORalpha1 COUP-TF c-Myb Sox9 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CXCL17
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCL17 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2CXCL17 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M042932: view genomic region
(about GC identifiers)
Start:
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42,932,695 bp from pter |
End:
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42,947,136 bp from pter |
Size:
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14,442 bases |
Orientation:
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minus strand |
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Proteins
for CXCL17 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: VCC1_HUMAN, Q6UXB2 (See
protein sequence)Recommended Name: VEGF co-regulated chemokine 1 precursor Size: 119 amino acids; 13819 Da
Subcellular location: Secreted
Developmental stage: Detected in fetal lung
Secondary accessions: A8KAC0Explore the universe of human proteins at neXtProt for CXCL17: NX_Q6UXB2
CXCL17 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_940879.1
ENSEMBL proteins: ENSP00000345317
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
CXCL17 for ontologies About GeneDecksing
CXCL17 Antibody Products:
Assay Products for CXCL17: |
Protein
Domains /
Families
for CXCL17 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q6UXB2 UniProtKB/Swiss-Prot: VCC1_HUMAN, Q6UXB2Similarity: Belongs to the intercrine alpha (chemokine CxC) family |
Function
for CXCL17 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: VCC1_HUMAN, Q6UXB2Function: Plays a role in angiogenesis and possibly in the development of tumors. May be a housekeeping chemokineregulating recruitment of nonactivated blood monocytes and immature dendritic cells into tissues. May play a role inthe innate defense against infectionsInduction: Found to be up-regulated in duodenal mucosa during acute cholera
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL17
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for CXCL17 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL17 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL17 |
Animal Models:
Mouse knock-out Cxcl17tm1Lex for CXCL17
1 MGI phenotypic allele  for Cxcl17 (no phenotypes)
CXCL17 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CXCL17 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CXCL17
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
CXCL17 for ontologies About GeneDecksing
|
Drugs & Compounds
for CXCL17 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CXCL17
Search CenterWatch for drugs/clinical trials and news about CXCL17 / VCC1
|
Transcripts
for CXCL17 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CXCL17 gene: NM_198477.1 Unigene Cluster for CXCL17: Chemokine (C-X-C motif) ligand 17 Hs.445586 [show with all ESTs]Unigene Representative Sequence: BG5354851 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000341918(uc002otu.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL17 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL17
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CXCL17 (NM_198477) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CXCL17 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL17 |
Additional cDNA sequence: AK292985.1 AY358433.1 AY598464.1 BC093946.1 BC112095.1 5 DOTS entries: DT.101980768 DT.95263598 DT.121424030 DT.310278 DT.91706174 24/74 AceView cDNA sequences (see all 74): BF055365 BM766904 AI207071 NM_198477 AI860310 BM766526 CB242167 BX102380 BF196945 BM768531 AY358433 BM854000 C00521 BM769069 BM769732 BM982101 AW298444 BM831028 AA481852 AA366288 BE645174 BM766900 AA479746 AI474243
GeneLoc Exon Structure
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Expression
for CXCL17 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CXCL17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTTCAAGA
About this image
See CXCL17 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CXCL17
SOURCE GeneReport for Unigene cluster: Hs.445586
UniProtKB/Swiss-Prot: VCC1_HUMAN, Q6UXB2Tissue specificity: Detected in trachea, stomach, lung and skeletal muscle. Detected in intestine and in normal andasthmatic lung (at protein level). Breast tumors showed 3- to 24-fold up-regulation
SABiosciences Custom PCR Arrays for CXCL17
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CXCL17
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CXCL17 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXCL17 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL17 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL17 |
Orthologs
for CXCL17 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for CXCL17 gene from 1/4 species (see all 4) About this table
ENSEMBL Gene Tree for CXCL17 (if available)
TreeFam Gene Tree for CXCL17 (if available) |
Paralogs
for CXCL17 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CXCL17 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CXCL17 (42932695 - 42947136 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CXCL17
1 CNV: 5445 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CXCL17 |
|
Disorders
/ Diseases
for CXCL17 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CXCL17 for disorders About GeneDecksing
OMIM gene information: 611387
OMIM disorders: --
5  diseases for CXCL17: About MalaCardsduodenitis cholera hepatocellular carcinoma carcinoma
pancreatitis
Export disorders for CXCL17 gene to outside databases
|
Publications
for CXCL17 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CXCL17 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with CXCL17) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- VCC-1, a novel chemokine, promotes tumor growth. (PubMed id 16989774)1, 2, 9 Weinstein E.J.... Mazzarella R. (2006)
- Novel human dendritic cell- and monocyte-attracting chemokine-like protein identified by fold recognition methods. (PubMed id 16455961)1, 2 Pisabarro M.T.... Schmidt K.N. (2006)
- The chemokine and chemokine receptor superfamilies and their molecular evolution. (PubMed id 17201934)1, 3 Zlotnik A....Nomiyama H. (2006)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- VCC-1 over-expression inhibits cisplatin-induced apopt osis in HepG2 cells. (PubMed id 22425983)1 Zhou Z....Li M. (2012)
- CXCL17 is a mucosal chemokine elevated in idiopathic p ulmonary fibrosis that exhibits broad antimicrobial activity. (PubMed id 22611239)1 Burkhardt A.M....Zlotnik A. (2012)
- Site-directed mutagenesis of the CC chemokine binding protein 35K-Fc reveals residues essential for activity and mutations that incr ease the potency of CC chemokine blockade. (PubMed id 21586597)1 White G.E....Greaves D.R. (2011)
- CXCL17 and ICAM2 are associated with a potential anti -tumor immune response in early intraepithelial stages of human pancreatic carc inogenesis. (PubMed id 20955708)1 Hiraoka N....Kanai Y. (2011)
- Overexpression of VCC-1 gene in human hepatocellular carcinoma cells promotes cell proliferation and invasion. (PubMed id 19657564)1 Mu X....Li M. (2009)
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External Searches for CXCL17 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing CXCL17 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing CXCL17 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CXCL17 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CXCL17 | Pharmacogenomics, SNPs, Pathways | | Wikipedia | http://en.wikipedia.org/wiki/CXCL17 |
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| | |
About This Section
| Patent Information for CXCL17 gene:
Search GeneIP for patents involving CXCL17
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CXCL17 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CXCL17 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXCL17 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CXCL17 | | | OriGene Protein Over-expression Lysate for CXCL17 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CXCL17 | | OriGene 3'-UTR Clone for CXCL17 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL17 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL17 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |  |  |  |  | | | | | | Recombinant Protein for CXCL17 |
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 | | | CXCL17 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL17 |
|  |  |  | | | | Search ThermoFisher Antibodies for CXCL17 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL17 |
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