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Aliases for CXCL17 Gene

Aliases for CXCL17 Gene

  • C-X-C Motif Chemokine Ligand 17 2 3 5
  • Dendritic Cell And Monocyte Chemokine-Like Protein 3 4
  • Chemokine (C-X-C Motif) Ligand 17 2 3
  • VEGF Coregulated Chemokine 1 3 4
  • 6-Cys CXCL17 3 4
  • VCC1 3 4
  • DMC 3 4
  • VEGF Co-Regulated Chemokine 1 3
  • C-X-C Motif Chemokine 17 3
  • UNQ473 3
  • Dcip1 3
  • VCC-1 3

External Ids for CXCL17 Gene

Previous GeneCards Identifiers for CXCL17 Gene

  • GC19M047625
  • GC19M042932
  • GC19M039362

Summaries for CXCL17 Gene

Entrez Gene Summary for CXCL17 Gene

  • The protein encoded by this gene is a mucosal chemokine that attracts immature dendritic cells and blood monocytes to the lungs. The encoded protein also promotes tumorigenesis through an angiogenic activity. Finally, this protein exhibits strong antimicrobial activity against E. coli, S. aureus, Salmonella, P. aeruginosa, and C. albicans. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for CXCL17 Gene

CXCL17 (C-X-C Motif Chemokine Ligand 17) is a Protein Coding gene. Diseases associated with CXCL17 include Cholera. Among its related pathways are Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions.

UniProtKB/Swiss-Prot for CXCL17 Gene

  • Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells (PubMed:16455961, PubMed:23115081). Plays a role in angiogenesis and possibly in the development of tumors (PubMed:16989774, PubMed:23115081). Acts as an anti-inflammatory in the stomach (PubMed:23115081). May play a role in the innate defense against infections (PubMed:17307946). Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions (PubMed:25411203).

  • 4-Cys CXCL17: seems exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17.

Additional gene information for CXCL17 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL17 Gene

Genomics for CXCL17 Gene

Regulatory Elements for CXCL17 Gene

Enhancers for CXCL17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H042440 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9 +0.1 95 5 FOXA2 ARID4B DMAP1 YY1 ZNF416 ZNF143 RUNX3 REST PPARG KAT8 ZNF574 ZNF526 LIPE-AS1 CNFN CXCL17 PSG8 ENSG00000268355 CD177 GC19P042435
GH19H042496 1.5 Ensembl ENCODE dbSUPER 8.4 -55.3 -55288 3 PKNOX1 FOXA2 ATF1 MLX ARID4B DMAP1 YY1 ATF7 RUNX3 JUNB CXCL17 ZNF526 CD177 MEGF8 LOC732229 LOC105372407
GH19H042480 1.5 Ensembl ENCODE dbSUPER 7.7 -38.1 -38115 1 PKNOX1 FOXA2 ARID4B SLC30A9 SP5 NFYC PPARG KAT8 NFIL3 MIER3 CXCL17 PSG8 ENSG00000268355 GC19M042479 RNU4-60P
GH19H042526 1.2 Ensembl ENCODE 9.3 -85.2 -85162 3 HDGF MLX ARID4B YY1 ZNF143 RUNX3 SP5 REST PPARG KAT8 CXCL17 ENSG00000268355 LOC105372407 CEACAM1
GH19H042465 1.1 Ensembl ENCODE 8.2 -23.4 -23411 2 HDGF TBL1XR1 RAD21 ZNF143 ETV6 RUNX3 CREM IKZF2 CBFB ZNF217 CXCL17 CD177 PIR51613 RNU4-60P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CXCL17 on UCSC Golden Path with GeneCards custom track

Genomic Location for CXCL17 Gene

Chromosome:
19
Start:
42,428,288 bp from pter
End:
42,443,048 bp from pter
Size:
14,761 bases
Orientation:
Minus strand

Genomic View for CXCL17 Gene

Genes around CXCL17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCL17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCL17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL17 Gene

Proteins for CXCL17 Gene

  • Protein details for CXCL17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXB2-CXL17_HUMAN
    Recommended name:
    C-X-C motif chemokine 17
    Protein Accession:
    Q6UXB2
    Secondary Accessions:
    • A8KAC0

    Protein attributes for CXCL17 Gene

    Size:
    119 amino acids
    Molecular mass:
    13819 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CXCL17 Gene

Post-translational modifications for CXCL17 Gene

  • Likely to undergo an endoproteolytic process to form a four-cysteine-containing mature peptide with a canonical CXC chemokine scaffold after secretion.

Other Protein References for CXCL17 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CXCL17 (CXCL17/VCC-1)
  • Santa Cruz Biotechnology (SCBT) Antibodies for CXCL17

No data available for DME Specific Peptides for CXCL17 Gene

Domains & Families for CXCL17 Gene

Gene Families for CXCL17 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for CXCL17 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CXCL17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UXB2

UniProtKB/Swiss-Prot:

CXL17_HUMAN :
  • Belongs to the intercrine alpha (chemokine CxC) family.
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL17: view

Function for CXCL17 Gene

Molecular function for CXCL17 Gene

UniProtKB/Swiss-Prot Function:
Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells (PubMed:16455961, PubMed:23115081). Plays a role in angiogenesis and possibly in the development of tumors (PubMed:16989774, PubMed:23115081). Acts as an anti-inflammatory in the stomach (PubMed:23115081). May play a role in the innate defense against infections (PubMed:17307946). Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions (PubMed:25411203).
UniProtKB/Swiss-Prot Function:
4-Cys CXCL17: seems exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17.
UniProtKB/Swiss-Prot Induction:
Found to be up-regulated in duodenal mucosa during acute cholera.
genes like me logo Genes that share phenotypes with CXCL17: view

Animal Models for CXCL17 Gene

MGI Knock Outs for CXCL17:

Animal Model Products

  • Taconic Biosciences Mouse Models for CXCL17

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CXCL17
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CXCL17 Gene

Localization for CXCL17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL17 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXCL17 gene
Compartment Confidence
extracellular 5
lysosome 1

Gene Ontology (GO) - Cellular Components for CXCL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IMP 23115081
genes like me logo Genes that share ontologies with CXCL17: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CXCL17 Gene

Pathways & Interactions for CXCL17 Gene

genes like me logo Genes that share pathways with CXCL17: view

Pathways by source for CXCL17 Gene

Interacting Proteins for CXCL17 Gene

Selected Interacting proteins: Q6UXB2-CXL17_HUMAN for CXCL17 Gene via IID

Gene Ontology (GO) - Biological Process for CXCL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IMP 23115081
GO:0001525 angiogenesis IEA --
GO:0006935 chemotaxis IEA --
GO:0007275 multicellular organism development IEA --
GO:0010575 positive regulation of vascular endothelial growth factor production IMP 23115081
genes like me logo Genes that share ontologies with CXCL17: view

No data available for SIGNOR curated interactions for CXCL17 Gene

Drugs & Compounds for CXCL17 Gene

No Compound Related Data Available

Transcripts for CXCL17 Gene

mRNA/cDNA for CXCL17 Gene

Unigene Clusters for CXCL17 Gene

Chemokine (C-X-C motif) ligand 17:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CXCL17
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL17 Gene

No ASD Table

Relevant External Links for CXCL17 Gene

GeneLoc Exon Structure for
CXCL17
ECgene alternative splicing isoforms for
CXCL17

Expression for CXCL17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXCL17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CXCL17 Gene

This gene is overexpressed in Stomach (x16.0), Minor Salivary Gland (x11.6), Esophagus - Mucosa (x9.8), and Lung (x5.5).

Protein differential expression in normal tissues from HIPED for CXCL17 Gene

This gene is overexpressed in Lung (45.7) and Pancreas (23.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CXCL17 Gene



Protein tissue co-expression partners for CXCL17 Gene

NURSA nuclear receptor signaling pathways regulating expression of CXCL17 Gene:

CXCL17

SOURCE GeneReport for Unigene cluster for CXCL17 Gene:

Hs.445586

mRNA Expression by UniProt/SwissProt for CXCL17 Gene:

Q6UXB2-CXL17_HUMAN
Tissue specificity: Detected in trachea, stomach, lung and skeletal muscle. Detected in intestine and in normal and asthmatic lung (at protein level). Breast tumors showed 3- to 24-fold up-regulation.

Evidence on tissue expression from TISSUES for CXCL17 Gene

  • Lung(4.5)
  • Heart(4)
  • Stomach(2.3)
genes like me logo Genes that share expression patterns with CXCL17: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCL17 Gene

Orthologs for CXCL17 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CXCL17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXCL17 33 34
  • 98.6 (n)
cow
(Bos Taurus)
Mammalia CXCL17 33 34
  • 84.42 (n)
dog
(Canis familiaris)
Mammalia CXCL17 34
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cxcl17 33 16 34
  • 80.33 (n)
rat
(Rattus norvegicus)
Mammalia Cxcl17 33
  • 78 (n)
Species where no ortholog for CXCL17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL17 Gene

ENSEMBL:
Gene Tree for CXCL17 (if available)
TreeFam:
Gene Tree for CXCL17 (if available)

Paralogs for CXCL17 Gene

No data available for Paralogs for CXCL17 Gene

Variants for CXCL17 Gene

Sequence variations from dbSNP and Humsavar for CXCL17 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000020124 -- 42,428,236(+) AGTCA(C/T)AAATA intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1000057023 -- 42,430,856(+) TTTTT(G/T)AGATG intron-variant
rs1000194157 -- 42,434,957(+) GGCGG(A/T)TCATG intron-variant
rs1000211965 -- 42,434,541(+) CTCCC(A/G)TCTCA intron-variant
rs1000231020 -- 42,440,987(+) CACAA(C/T)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CXCL17 Gene

Variant ID Type Subtype PubMed ID
esv2422471 CNV deletion 17116639
nsv526186 CNV gain 19592680

Variation tolerance for CXCL17 Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CXCL17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXCL17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL17 Gene

Disorders for CXCL17 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CXCL17 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cholera
  • cholera - vibrio cholerae
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CXCL17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CXCL17
genes like me logo Genes that share disorders with CXCL17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL17 Gene

Publications for CXCL17 Gene

  1. VCC-1, a novel chemokine, promotes tumor growth. (PMID: 16989774) Weinstein EJ … Mazzarella R (Biochemical and biophysical research communications 2006) 3 4 22 60
  2. Cutting edge: GPR35/CXCR8 is the receptor of the mucosal chemokine CXCL17. (PMID: 25411203) Maravillas-Montero JL … Zlotnik A (Journal of immunology (Baltimore, Md. : 1950) 2015) 3 4 60
  3. CXCL17, an orphan chemokine, acts as a novel angiogenic and anti-inflammatory factor. (PMID: 23115081) Lee WY … Luo CW (American journal of physiology. Endocrinology and metabolism 2013) 3 4 60
  4. The chemokine and chemokine receptor superfamilies and their molecular evolution. (PMID: 17201934) Zlotnik A … Nomiyama H (Genome biology 2006) 2 3 60
  5. Cutting edge: novel human dendritic cell- and monocyte-attracting chemokine-like protein identified by fold recognition methods. (PMID: 16455961) Pisabarro MT … Schmidt KN (Journal of immunology (Baltimore, Md. : 1950) 2006) 3 4 60

Products for CXCL17 Gene

Sources for CXCL17 Gene

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