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Aliases for CXCL16 Gene

Aliases for CXCL16 Gene

  • C-X-C Motif Chemokine Ligand 16 2 3 5
  • Scavenger Receptor For Phosphatidylserine And Oxidized Low Density Lipoprotein 3 4
  • Chemokine (C-X-C Motif) Ligand 16 2 3
  • Transmembrane Chemokine CXCL16 3 4
  • Small-Inducible Cytokine B16 3 4
  • CXC Chemokine Ligand 16 2 3
  • SR-PSOX 3 4
  • SRPSOX 3 4
  • C-X-C Motif Chemokine 16 3
  • CXCLG16 3
  • SCYB16 4

External Ids for CXCL16 Gene

Previous GeneCards Identifiers for CXCL16 Gene

  • GC17M005063
  • GC17M004982
  • GC17M004587
  • GC17M004843
  • GC17M004583
  • GC17M004637
  • GC17M004527

Summaries for CXCL16 Gene

GeneCards Summary for CXCL16 Gene

CXCL16 (C-X-C Motif Chemokine Ligand 16) is a Protein Coding gene. Diseases associated with CXCL16 include Xanthogranulomatous Cholecystitis. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include chemokine activity and low-density lipoprotein receptor activity.

UniProtKB/Swiss-Prot for CXCL16 Gene

  • Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL16 Gene

Genomics for CXCL16 Gene

Regulatory Elements for CXCL16 Gene

Enhancers for CXCL16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F004735 0.4 ENCODE 32.2 +3.6 3607 1.7 CTCF PKNOX1 ETV1 SIN3A RAD21 ZNF335 CTBP1 GATA3 ZBTB48 PATZ1 CXCL16 ENSG00000261898
GH17F004724 0.8 Ensembl ENCODE 26.7 +14.2 14227 2.2 CTCF ZNF362 ESRRA PRDM10 MLLT1 ZNF18 EGR2 CXCL16 MINK1 GGT6 LOC101928000 ZFP3 MED11 GC17P004725 GC17M004721
GH17F004738 0.2 ENCODE 20 +0.7 691 2.2 SIN3A ZNF2 GLIS2 CREM EGR2 ZNF263 ZHX2 MXD4 ZEB2 TGIF2 CXCL16 ENSG00000261898
GH17F004732 0.4 ENCODE 18.5 +6.4 6444 1.2 CTCF PKNOX1 RAD21 ZFHX2 EED SMC3 ETV6 CREM MTA2 JUNB CXCL16 LOC105371506 ENSG00000261898
GH17F004730 0.4 ENCODE 18.5 +8.6 8622 2.0 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CXCL16 NUP88 DERL2 ZNF594 LOC101927979 LOC100130950 ZNF232 LOC101928000 MED11 GC17M004714
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CXCL16 on UCSC Golden Path with GeneCards custom track

Promoters for CXCL16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001339607 628 1801 ZNF133 SIN3A ZNF2 GLIS2 CREM EGR2 ZNF263 ZHX2 MXD4 ZEB2

Genomic Location for CXCL16 Gene

Chromosome:
17
Start:
4,733,526 bp from pter
End:
4,739,928 bp from pter
Size:
6,403 bases
Orientation:
Minus strand

Genomic View for CXCL16 Gene

Genes around CXCL16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCL16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCL16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL16 Gene

Proteins for CXCL16 Gene

  • Protein details for CXCL16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2A7-CXL16_HUMAN
    Recommended name:
    C-X-C motif chemokine 16
    Protein Accession:
    Q9H2A7
    Secondary Accessions:
    • A0N0N4
    • A8K7U9
    • B2RCB0
    • Q8TC80
    • Q96K63
    • Q9BXD6
    • Q9H2F6

    Protein attributes for CXCL16 Gene

    Size:
    254 amino acids
    Molecular mass:
    27579 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG34365.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH17588.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH44930.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=ABK41925.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55078.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAF84803.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG37507.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CXCL16 Gene

Post-translational modifications for CXCL16 Gene

Other Protein References for CXCL16 Gene

Antibody Products

  • Abcam antibodies for CXCL16
  • Cloud-Clone Corp. Antibodies for CXCL16

No data available for DME Specific Peptides for CXCL16 Gene

Domains & Families for CXCL16 Gene

Protein Domains for CXCL16 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CXCL16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H2A7

UniProtKB/Swiss-Prot:

CXL16_HUMAN :
  • Belongs to the intercrine alpha (chemokine CxC) family.
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL16: view

Function for CXCL16 Gene

Molecular function for CXCL16 Gene

UniProtKB/Swiss-Prot Function:
Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.

Gene Ontology (GO) - Molecular Function for CXCL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005041 low-density lipoprotein receptor activity ISS --
GO:0005044 scavenger receptor activity IEA,TAS 11060282
GO:0005125 cytokine activity IEA --
GO:0008009 chemokine activity IEA,ISS --
GO:0042379 chemokine receptor binding IEA --
genes like me logo Genes that share ontologies with CXCL16: view
genes like me logo Genes that share phenotypes with CXCL16: view

Animal Models for CXCL16 Gene

MGI Knock Outs for CXCL16:

Animal Model Products

  • Taconic Biosciences Mouse Models for CXCL16

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CXCL16 Gene

Localization for CXCL16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL16 Gene

Cell membrane; Single-pass type I membrane protein. Secreted. Note=Also exists as a soluble form.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CXCL16 Gene COMPARTMENTS Subcellular localization image for CXCL16 gene
Compartment Confidence
extracellular 5
plasma membrane 4
nucleus 1

Gene Ontology (GO) - Cellular Components for CXCL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 18373975
GO:0005886 plasma membrane IEA --
GO:0016020 membrane TAS 11060282
GO:0016021 integral component of membrane NAS 11290797
genes like me logo Genes that share ontologies with CXCL16: view

Pathways & Interactions for CXCL16 Gene

genes like me logo Genes that share pathways with CXCL16: view

Gene Ontology (GO) - Biological Process for CXCL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IEA,NAS 11060282
GO:0006935 chemotaxis IEA,NAS 11290797
GO:0010818 T cell chemotaxis IBA --
GO:0030307 positive regulation of cell growth IEA,IMP 18373975
GO:0030335 positive regulation of cell migration IEA,IMP 18373975
genes like me logo Genes that share ontologies with CXCL16: view

No data available for SIGNOR curated interactions for CXCL16 Gene

Drugs & Compounds for CXCL16 Gene

(2) Drugs for CXCL16 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(125) Additional Compounds for CXCL16 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PS(14:0/14:0)
  • 1-Myristoyl-2-myristoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:0)
  • Phosphatidylserine(28:0)
  • PS(14:0/14:0)
  • PS(28:0)
PS(14:0/14:1(9Z))
  • 1-Myristoyl-2-myristoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:1)
  • Phosphatidylserine(14:0/14:1n5)
  • Phosphatidylserine(14:0/14:1w5)
  • Phosphatidylserine(28:1)
PS(14:0/16:0)
  • 1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:0)
  • Phosphatidylserine(30:0)
  • PS(14:0/16:0)
  • PS(30:0)
PS(14:0/16:1(9Z))
  • 1-Myristoyl-2-palmitoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:1)
  • Phosphatidylserine(14:0/16:1n7)
  • Phosphatidylserine(14:0/16:1w7)
  • Phosphatidylserine(30:1)
PS(14:0/18:0)
  • 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/18:0)
  • Phosphatidylserine(32:0)
  • PS(14:0/18:0)
  • PS(32:0)
genes like me logo Genes that share compounds with CXCL16: view

Transcripts for CXCL16 Gene

Unigene Clusters for CXCL16 Gene

Chemokine (C-X-C motif) ligand 16:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL16 Gene

No ASD Table

Relevant External Links for CXCL16 Gene

GeneLoc Exon Structure for
CXCL16
ECgene alternative splicing isoforms for
CXCL16

Expression for CXCL16 Gene

mRNA expression in normal human tissues for CXCL16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CXCL16 Gene

This gene is overexpressed in Whole Blood (x8.6) and Testis (x7.4).

Protein differential expression in normal tissues from HIPED for CXCL16 Gene

This gene is overexpressed in Bone (54.6) and Islet of Langerhans (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CXCL16 Gene



Protein tissue co-expression partners for CXCL16 Gene

NURSA nuclear receptor signaling pathways regulating expression of CXCL16 Gene:

CXCL16

SOURCE GeneReport for Unigene cluster for CXCL16 Gene:

Hs.745037

mRNA Expression by UniProt/SwissProt for CXCL16 Gene:

Q9H2A7-CXL16_HUMAN
Tissue specificity: Expressed in T-cell areas. Expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. Weak expression in heart and liver and no expression in brain and bone marrow.
genes like me logo Genes that share expression patterns with CXCL16: view

Primer Products

Orthologs for CXCL16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CXCL16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXCL16 34 35
  • 98.78 (n)
dog
(Canis familiaris)
Mammalia CXCL16 34 35
  • 73.65 (n)
mouse
(Mus musculus)
Mammalia Cxcl16 34 16 35
  • 68.33 (n)
rat
(Rattus norvegicus)
Mammalia Cxcl16 34
  • 68.19 (n)
cow
(Bos Taurus)
Mammalia CXCL16 34 35
  • 66.67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CXCL16 35
  • 26 (a)
OneToOne
Species where no ortholog for CXCL16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL16 Gene

ENSEMBL:
Gene Tree for CXCL16 (if available)
TreeFam:
Gene Tree for CXCL16 (if available)

Paralogs for CXCL16 Gene

No data available for Paralogs for CXCL16 Gene

Variants for CXCL16 Gene

Sequence variations from dbSNP and Humsavar for CXCL16 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1050997 -- 4,738,460(-) TGTGG(A/G)GGCAA upstream-variant-2KB, reference, synonymous-codon
rs1050998 -- 4,735,442(-) CCCAA(C/T)TTCTC reference, missense
rs1051007 -- 4,733,518(-) ATGTA(C/T)TTTCA intron-variant, utr-variant-3-prime
rs1051009 -- 4,734,591(-) GGAAG(C/T)TTGTG utr-variant-3-prime
rs1078801 -- 4,740,187(-) AACGG(C/T)TTGGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CXCL16 Gene

Variant ID Type Subtype PubMed ID
dgv525e199 CNV deletion 23128226
esv3168235 CNV deletion 24192839
esv3554041 CNV deletion 23714750
nsv1952 CNV insertion 18451855
nsv574273 CNV gain 21841781
nsv833346 CNV loss 17160897

Variation tolerance for CXCL16 Gene

Residual Variation Intolerance Score: 80.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.64; 72.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CXCL16 Gene

Human Gene Mutation Database (HGMD)
CXCL16
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXCL16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL16 Gene

Disorders for CXCL16 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CXCL16 Gene - From: GeneCards

Disorder Aliases PubMed IDs
xanthogranulomatous cholecystitis
  • cx
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CXCL16

Genetic Association Database (GAD)
CXCL16
Human Genome Epidemiology (HuGE) Navigator
CXCL16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CXCL16
genes like me logo Genes that share disorders with CXCL16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL16 Gene

Publications for CXCL16 Gene

  1. A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. (PMID: 11017100) Matloubian M. … Cyster J.G. (Nat. Immunol. 2000) 2 3 4 22 64
  2. Molecular cloning of a novel scavenger receptor for oxidized low density lipoprotein, SR-PSOX, on macrophages. (PMID: 11060282) Shimaoka T. … Yonehara S. (J. Biol. Chem. 2000) 2 3 4 64
  3. An intron polymorphism in the CXCL16 gene is associated with increased risk of coronary artery disease in Chinese Han population: a large angiography-based study. (PMID: 19954776) Huang M. … Yan C. (Atherosclerosis 2010) 3 46 64
  4. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A. … Janssen R. (Pediatr. Pulmonol. 2010) 3 46 64
  5. Chemokine CXC Ligand 16 serum concentration but not A181V genotype is associated with atherosclerotic stroke. (PMID: 20621591) Wang K.D. … Kang X.X. (Clin. Chim. Acta 2010) 3 46 64

Products for CXCL16 Gene

  • Cloud-Clone Corp. Antibodies for CXCL16
  • Cloud-Clone Corp. Proteins for CXCL16
  • Cloud-Clone Corp Assay Kits for CXCL16

Sources for CXCL16 Gene

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