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Aliases for CXCL16 Gene

Aliases for CXCL16 Gene

  • Chemokine (C-X-C Motif) Ligand 16 2 3
  • Scavenger Receptor For Phosphatidylserine And Oxidized Low Density Lipoprotein 3 4
  • Transmembrane Chemokine CXCL16 3 4
  • Small-Inducible Cytokine B16 3 4
  • CXC Chemokine Ligand 16 2 3
  • SR-PSOX 3 4
  • SRPSOX 3 4
  • CXCLG16 3
  • SCYB16 4

External Ids for CXCL16 Gene

Previous GeneCards Identifiers for CXCL16 Gene

  • GC17M005063
  • GC17M004982
  • GC17M004587
  • GC17M004843
  • GC17M004583
  • GC17M004637
  • GC17M004527

Summaries for CXCL16 Gene

GeneCards Summary for CXCL16 Gene

CXCL16 (Chemokine (C-X-C Motif) Ligand 16) is a Protein Coding gene. Diseases associated with CXCL16 include xanthogranulomatous cholecystitis. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include chemokine activity and low-density lipoprotein receptor activity.

UniProtKB/Swiss-Prot for CXCL16 Gene

  • Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL16 Gene

Genomics for CXCL16 Gene

Regulatory Elements for CXCL16 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CXCL16 Gene

Chromosome:
17
Start:
4,733,526 bp from pter
End:
4,739,928 bp from pter
Size:
6,403 bases
Orientation:
Minus strand

Genomic View for CXCL16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CXCL16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL16 Gene

Proteins for CXCL16 Gene

  • Protein details for CXCL16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2A7-CXL16_HUMAN
    Recommended name:
    C-X-C motif chemokine 16
    Protein Accession:
    Q9H2A7
    Secondary Accessions:
    • A0N0N4
    • A8K7U9
    • B2RCB0
    • Q8TC80
    • Q96K63
    • Q9BXD6
    • Q9H2F6

    Protein attributes for CXCL16 Gene

    Size:
    254 amino acids
    Molecular mass:
    27579 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG34365.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH17588.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH44930.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=ABK41925.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55078.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAF84803.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG37507.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CXCL16 Gene

Proteomics data for CXCL16 Gene at MOPED

Post-translational modifications for CXCL16 Gene

Other Protein References for CXCL16 Gene

Antibody Products

No data available for DME Specific Peptides for CXCL16 Gene

Domains & Families for CXCL16 Gene

Gene Families for CXCL16 Gene

Protein Domains for CXCL16 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CXCL16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H2A7

UniProtKB/Swiss-Prot:

CXL16_HUMAN :
  • Belongs to the intercrine alpha (chemokine CxC) family.
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL16: view

Function for CXCL16 Gene

Molecular function for CXCL16 Gene

UniProtKB/Swiss-Prot Function:
Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.

Gene Ontology (GO) - Molecular Function for CXCL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005041 low-density lipoprotein receptor activity ISS --
GO:0005044 scavenger receptor activity TAS 11060282
GO:0008009 chemokine activity ISS --
GO:0042379 chemokine receptor binding --
genes like me logo Genes that share ontologies with CXCL16: view
genes like me logo Genes that share phenotypes with CXCL16: view

Animal Models for CXCL16 Gene

MGI Knock Outs for CXCL16:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CXCL16

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CXCL16 Gene

Localization for CXCL16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL16 Gene

Cell membrane; Single-pass type I membrane protein. Secreted. Note=Also exists as a soluble form.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CXCL16 Gene COMPARTMENTS Subcellular localization image for CXCL16 gene
Compartment Confidence
extracellular 5
plasma membrane 3
nucleus 1

Gene Ontology (GO) - Cellular Components for CXCL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 18373975
GO:0005886 plasma membrane IEA --
GO:0016020 membrane TAS 11060282
GO:0016021 integral component of membrane NAS 11290797
genes like me logo Genes that share ontologies with CXCL16: view

Pathways & Interactions for CXCL16 Gene

genes like me logo Genes that share pathways with CXCL16: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CXCL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis NAS 11060282
GO:0006935 chemotaxis NAS 11290797
GO:0010818 T cell chemotaxis IBA --
GO:0030307 positive regulation of cell growth IMP 18373975
GO:0030335 positive regulation of cell migration IMP 18373975
genes like me logo Genes that share ontologies with CXCL16: view

No data available for SIGNOR curated interactions for CXCL16 Gene

Drugs & Compounds for CXCL16 Gene

(2) Drugs for CXCL16 Gene - From: HMDB and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphatidylserine Approved Nutra 0
Calcium Nutra 0

(125) Additional Compounds for CXCL16 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PS(14:0/14:0)
  • 1-Myristoyl-2-myristoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:0)
  • Phosphatidylserine(28:0)
  • PS(14:0/14:0)
  • PS(28:0)
PS(14:0/14:1(9Z))
  • 1-Myristoyl-2-myristoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:1)
  • Phosphatidylserine(14:0/14:1n5)
  • Phosphatidylserine(14:0/14:1w5)
  • Phosphatidylserine(28:1)
PS(14:0/16:0)
  • 1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:0)
  • Phosphatidylserine(30:0)
  • PS(14:0/16:0)
  • PS(30:0)
PS(14:0/16:1(9Z))
  • 1-Myristoyl-2-palmitoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:1)
  • Phosphatidylserine(14:0/16:1n7)
  • Phosphatidylserine(14:0/16:1w7)
  • Phosphatidylserine(30:1)
PS(14:0/18:0)
  • 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/18:0)
  • Phosphatidylserine(32:0)
  • PS(14:0/18:0)
  • PS(32:0)
genes like me logo Genes that share compounds with CXCL16: view

Transcripts for CXCL16 Gene

Unigene Clusters for CXCL16 Gene

Chemokine (C-X-C motif) ligand 16:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CXCL16

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL16 Gene

No ASD Table

Relevant External Links for CXCL16 Gene

GeneLoc Exon Structure for
CXCL16
ECgene alternative splicing isoforms for
CXCL16

Expression for CXCL16 Gene

mRNA expression in normal human tissues for CXCL16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CXCL16 Gene

This gene is overexpressed in Whole Blood (x8.6) and Testis (x7.4).

Protein differential expression in normal tissues from HIPED for CXCL16 Gene

This gene is overexpressed in Bone (54.6) and Islet of Langerhans (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CXCL16 Gene



SOURCE GeneReport for Unigene cluster for CXCL16 Gene Hs.745037

mRNA Expression by UniProt/SwissProt for CXCL16 Gene

Q9H2A7-CXL16_HUMAN
Tissue specificity: Expressed in T-cell areas. Expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. Weak expression in heart and liver and no expression in brain and bone marrow
genes like me logo Genes that share expression patterns with CXCL16: view

Protein tissue co-expression partners for CXCL16 Gene

Primer Products

In Situ Assay Products

Orthologs for CXCL16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CXCL16 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CXCL16 35
  • 66.67 (n)
  • 56 (a)
CXCL16 36
  • 50 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CXCL16 35
  • 73.65 (n)
  • 61.14 (a)
CXCL16 36
  • 33 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cxcl16 35
  • 68.33 (n)
  • 51.13 (a)
Cxcl16 16
Cxcl16 36
  • 47 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CXCL16 35
  • 98.78 (n)
  • 97.07 (a)
CXCL16 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cxcl16 35
  • 68.19 (n)
  • 50.68 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia CXCL16 36
  • 26 (a)
OneToOne
Species with no ortholog for CXCL16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL16 Gene

ENSEMBL:
Gene Tree for CXCL16 (if available)
TreeFam:
Gene Tree for CXCL16 (if available)

Paralogs for CXCL16 Gene

No data available for Paralogs for CXCL16 Gene

Variants for CXCL16 Gene

Sequence variations from dbSNP and Humsavar for CXCL16 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1050998 -- 4,735,442(-) CCCAA(C/T)TTCTC missense, reference
rs1051009 -- 4,734,591(-) GGAAG(C/T)TTGTG utr-variant-3-prime
rs1876444 -- 4,735,189(+) AGGAC(C/T)GGCAC reference, synonymous-codon
rs2277680 - 4,735,268(+) GCCCA(A/G)CTGCC reference, missense
rs3191385 -- 4,735,205(-) CAGGA(A/C)ATCAG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for CXCL16 Gene

Variant ID Type Subtype PubMed ID
nsv833346 CNV Loss 17160897
nsv1952 CNV Insertion 18451855
dgv525e199 CNV Deletion 23128226

Variation tolerance for CXCL16 Gene

Residual Variation Intolerance Score: 80.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.64; 72.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CXCL16 Gene

HapMap Linkage Disequilibrium report
CXCL16
Human Gene Mutation Database (HGMD)
CXCL16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL16 Gene

Disorders for CXCL16 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CXCL16 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
xanthogranulomatous cholecystitis
  • cx
- elite association

Relevant External Links for CXCL16

Genetic Association Database (GAD)
CXCL16
Human Genome Epidemiology (HuGE) Navigator
CXCL16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CXCL16
genes like me logo Genes that share disorders with CXCL16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL16 Gene

Publications for CXCL16 Gene

  1. A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. (PMID: 11017100) Matloubian M. … Cyster J.G. (Nat. Immunol. 2000) 2 23 67
  2. Expression of CXCR6 on CD8(+) T cells was up-regulated in allograft rejection. (PMID: 20035869) Jiang X. … Liang J. (Transpl. Immunol. 2010) 23 67
  3. CXCL16 is expressed in podocytes and acts as a scavenger receptor for oxidized low-density lipoprotein. (PMID: 19435795) Gutwein P. … Pfeilschifter J. (Am. J. Pathol. 2009) 23 67
  4. Repair-related activation of hedgehog signaling promotes cholangiocyte chemokine production. (PMID: 19575365) Omenetti A. … Diehl A.M. (Hepatology 2009) 23 67
  5. The chemokine CXCL16 is highly and constitutively expressed by human bronchial epithelial cells. (PMID: 19415545) Day C. … Wardlaw A.J. (Exp. Lung Res. 2009) 23 67

Products for CXCL16 Gene

Sources for CXCL16 Gene

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