CXCL16 Gene

Aliases
for CXCL16 gene

Previous GC identifers: GC17M005063 GC17M004982 GC17M004587 GC17M004843 GC17M004583 GC17M004527

Summaries
for CXCL16 gene

Genomic Views
for CXCL16 gene

RefSeq DNA sequence:

NC_000017.10  NC_018928.1  NT_010718.16  

SwitchGear Promoter luciferase reporter plasmid: CXCL16 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCL16

CXCL16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M004637:  view genomic region     (about GC identifiers)

Proteins
for CXCL16 gene

Explore the universe of human proteins at neXtProt for CXCL16: NX_Q9H2A7

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CXCL16
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 3): CXCL16 OriGene Custom Protein Services for CXCL16
	GenScript Purified and Recombinant Proteins for CXCL16
	Novus Biologicals CXCL16 Proteins Novus Biologicals CXCL16 Lysates
	Sino Biological Recombinant Protein for CXCL16
	ProSpec Recombinant Protein for CXCL16
	Uscn Proteins for CXCL16

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CXCL16
	Browse OriGene Antibodies OriGene Custom Antibody Services for CXCL16
	GenScript Custom Superior Antibodies Services for CXCL16
	Novus Biologicals CXCL16 Antibodies
	Search for Antibodies for CXCL16 at Abcam
	Uscn Antibodies for CXCL16
	ThermoFisher Antibodies for CXCL16

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for CXCL16         (see all)
	GenScript Custom Assay Services for CXCL16
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CXCL16

Protein Domains /
Families
for CXCL16 gene

ProtoNet protein and cluster: Q9H2A7

Function
for CXCL16 gene

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CXCL16 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCL16
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL16:
		hsa-miR-1244 hsa-miR-3153
		SwitchGear 3'UTR luciferase reporter plasmid: CXCL16 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXCL16 (see all 7) OriGene shRNA RFP: CXCL16 OriGene siRNA: CXCL16
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCL16

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CXCL16

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL16 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL16 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CXCL16 (NM_022059)
		Sino Biological Human cDNA Clone for CXCL16
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL16
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL16

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CXCL16
		Search LifeMap BioReagents cell lines for CXCL16

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL16

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

(inferred from 3 alleles) (MGI details for Cxcl16)

Pathways & Interactions
for CXCL16 gene

	Super-pathway	contained gene-specific pathways
1	PEDF Induced Signaling	8/9 pathways (see all 9) PEDF Induced Signaling 1.00 RAR-Gamma-RXR-Alpha Degradation 0.54 MIF Mediated Glucocorticoid Regulation 0.73 STAT3 Pathway 0.47 MIF Regulation of Innate Immune Cells 0.71 Endothelin-1 Signaling Pathway 0.44 IL-6 Pathway 0.61 Cytokine-cytokine receptor interaction 0.26
2	Class A/1 (Rhodopsin-like receptors)	Class A/1 (Rhodopsin-like receptors) 1.00 Peptide ligand-binding receptors 0.61 GPCR ligand binding 0.75 G alpha (i) signalling events 0.44
3	Rho Family GTPases	Rho Family GTPases 1.00 Molecular Mechanisms of Cancer 0.51 ERK Signaling 0.61
4	Signaling by GPCR	Signaling by GPCR 1.00 Signal Transduction 0.56 GPCR downstream signaling 0.89
5	PAK Pathway	PAK Pathway 1.00 Antioxidant Action of Vitamin-C 0.56

5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CXCL16

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	Transendothelial Migration of Leukocytes
	MIF Mediated Glucocorticoid Regulation

5/8        Reactome Pathways for CXCL16

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Chemokine receptors bind chemokines
	Signal Transduction
	Signaling by GPCR

2         Kegg Pathways  (Kegg details for CXCL16)

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

Drugs & Compounds
for CXCL16 gene

Transcripts
for CXCL16 gene

Expression
for CXCL16 gene

CXCL16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGGCCCTA

2 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BrainMeninges			Brain
	Umbilical CordUmbilical Veins			Umbilical Cord
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 2 LifeMap Cells
	Name			Category
	PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)			Endothelium
	PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CXCL16 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CXCL16
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXCL16
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL16

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL16

Orthologs
for CXCL16 gene

Paralogs
for CXCL16 gene

Genomic Variants
for CXCL16 gene

10/188 NCBI SNPs in CXCL16 are shown (see all 188)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs81231,2	C,F,A,H,	--	4636565(-)	CTCATA/CCTCCC	2	--	int1 ut31		30		EA MN NA NS WA CSA	4468
rs1138541541,2	C,F,	--	4636582(+)	CATACC/TCTGCT	2	--	ut31 int1		4		CSA WA EA	243
rs1442602101,2	C,	--	4636638(+)	AACTG-/AAGCCC	2	--	ut31 int1		0	--	--	--	--
rs65028191,2	C,F,H,	--	4636664(+)	TATGCC/TTTGGC	1	--	int1		21		NS EA NA WA CSA	1468
rs1908333371,2		--	4636764(+)	CTCAAA/GCACTT	2	--	int1 ut31		0	--	--	--	--
rs1487344261,2		--	4636793(+)	TTCCCA/GCAGAC	2	--	ut31 int1		0	--	--	--	--
rs10510071,2	C,F,O,A,H,	--	4636813(-)	ATGTAT/CTTTCA	2	--	int1 ut31		22		MN NA NS EA WA	2654
rs1170482731,2		--	4636831(+)	CATTCG/AGAGAG	2	--	ut31		1		NA	120
rs47906961,2	C,H,	--	4637016(+)	CTTCGT/CTGCGG	1	--	int1 ese3		17		NA WA CSA EA	519
rs1812525491,2		--	4637141(+)	AGGGCA/GCAAGG	2	--	int1 ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for CXCL16 (4636821 - 4643223 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CXCL16
     1 CNV: 4985
Human Gene Mutation Database (HGMD): CXCL16

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CXCL16

DNA2.0 Custom Variant and Variant Library Synthesis for CXCL16

Disorders / Diseases
for CXCL16 gene

20/26 diseases for CXCL16

5 Novoseek disease relationships for CXCL16 gene    About this table

Publications
for CXCL16 gene

PubMed articles for CXCL16 gene, integrated from 9 sources (see all 107): (articles sorted by number of sources associating them with CXCL16)

Utopia: connect your pdf to the dynamic world of online information

1. A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. (PubMed id 11017100)^{1, 2, 3, 9} Matloubian M.... Cyster J.G. (2000)
2. Molecular cloning of a novel scavenger receptor for oxidized low density lipoprotein, SR-PSOX, on macrophages. (PubMed id 11060282)^{1, 2, 3} Shimaoka T....Yonehara S. (2000)
3. Severity of coronary artery stenosis is associated with a polymorphism in the CXCL16/SR-PSOX gene. (PubMed id 15836657)^{1, 4} Lundberg G.A....Eriksson P. (2005)
4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
7. Expression cloning of the strl33/bonzo/tymstr ligand reveals elements of cc, cxc, and cx3c chemokines. (PubMed id 11290797)^{1, 2} Wilbanks A.... Briskin M. (2001)
8. The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10. (PubMed id 15128827)^{1, 9} Abel S....Ludwig A. (2004)
9. CXCL16 functions as a novel chemotactic factor for prostate cancer cells in vitro. (PubMed id 18344492)^{1, 9} Lu Y....Zhang J. (2008)
10. Expression and potential function of the CXC chemokine CXCL16 in pancreatic ductal adenocarcinoma. (PubMed id 18636150)^{1, 9} Wente M.N....Friess H. (2008)

External Searches for CXCL16 gene

Genome Databases showing CXCL16 gene

Other Databases showing CXCL16 gene

Specialized Databases showing CXCL16 gene

Products
for CXCL16 gene