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Aliases for CXCL14 Gene

Aliases for CXCL14 Gene

  • C-X-C Motif Chemokine Ligand 14 2 3 5
  • Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 14 (BRAK) 2 3
  • Chemokine (C-X-C Motif) Ligand 14 2 3
  • Small-Inducible Cytokine B14 3 4
  • Breast And Kidney 2 3
  • Chemokine BRAK 3 4
  • MIP-2g 3 4
  • SCYB14 3 4
  • MIP2G 3 4
  • NJAC 3 4
  • CXC Chemokine In Breast And Kidney 3
  • Tumor-Suppressing Chemokine 3
  • C-X-C Motif Chemokine 14 3
  • MIP-2 Gamma 3
  • Bolekine 3
  • BMAC 3
  • BRAK 3
  • KEC 3
  • KS1 3

External Ids for CXCL14 Gene

Previous HGNC Symbols for CXCL14 Gene

  • SCYB14

Previous GeneCards Identifiers for CXCL14 Gene

  • GC05M134742
  • GC05M134937
  • GC05M134982
  • GC05M134934
  • GC05M130094

Summaries for CXCL14 Gene

Entrez Gene Summary for CXCL14 Gene

  • This antimicrobial gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. [provided by RefSeq, Sep 2014]

GeneCards Summary for CXCL14 Gene

CXCL14 (C-X-C Motif Chemokine Ligand 14) is a Protein Coding gene. Diseases associated with CXCL14 include Squamous Cell Carcinoma, Head And Neck and Pelvic Lipomatosis. Among its related pathways are PEDF Induced Signaling and Akt Signaling. GO annotations related to this gene include chemokine activity.

UniProtKB/Swiss-Prot for CXCL14 Gene

  • Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL14 Gene

Genomics for CXCL14 Gene

Regulatory Elements for CXCL14 Gene

Enhancers for CXCL14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F135455 1.7 FANTOM5 Ensembl ENCODE 10.3 +122.5 122493 2.4 ATF1 ZNF48 ZNF2 ZNF143 FOS ZNF263 JUNB REST SMARCA4 MYNN TIFAB ENSG00000250167 CXCL14 H2AFY NEUROG1
GH05F135481 1.3 Ensembl ENCODE 11 +97.3 97253 1.5 HDGF ARNT MLX ARID4B GLI4 DMAP1 ZNF48 ELK1 GATA2 ZNF416 ENSG00000250167 NEUROG1 CXCL14 SEC24A ENSG00000254239 TIFAB
GH05F135488 1.2 Ensembl ENCODE 11.1 +89.6 89596 2.6 ZNF48 GLIS2 KLF7 ZNF263 SP3 SP5 NFYC ZNF610 SMARCA4 GLIS1 NEUROG1 ENSG00000250167 CXCL14 TIFAB ENSG00000249639 JADE2 ENSG00000270021
GH05F135308 1.1 Ensembl ENCODE 9.9 +269.9 269908 2.9 MLX RARA YY1 FOS CREM EGR2 SMARCA5 ZNF781 ZNF518A NR2F2 ENSG00000250167 CXCL14 GC05M135339 GC05M135248
GH05F135304 1.1 Ensembl ENCODE 9.9 +274.8 274759 0.2 ARID4B DMAP1 THRB RAD21 RARA CREM SMARCA5 HMG20B RCOR2 GLIS1 ENSG00000250167 CXCL14 GC05M135339 GC05M135248
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CXCL14 on UCSC Golden Path with GeneCards custom track

Genomic Location for CXCL14 Gene

Chromosome:
5
Start:
135,570,679 bp from pter
End:
135,579,279 bp from pter
Size:
8,601 bases
Orientation:
Minus strand

Genomic View for CXCL14 Gene

Genes around CXCL14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCL14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCL14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL14 Gene

Proteins for CXCL14 Gene

  • Protein details for CXCL14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95715-CXL14_HUMAN
    Recommended name:
    C-X-C motif chemokine 14
    Protein Accession:
    O95715
    Secondary Accessions:
    • B3KQU8
    • Q6UW97
    • Q86U69
    • Q9BTR1
    • Q9NS21

    Protein attributes for CXCL14 Gene

    Size:
    111 amino acids
    Molecular mass:
    13078 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD38944.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CXCL14 Gene

neXtProt entry for CXCL14 Gene

Post-translational modifications for CXCL14 Gene

Other Protein References for CXCL14 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for CXCL14

No data available for DME Specific Peptides for CXCL14 Gene

Domains & Families for CXCL14 Gene

Gene Families for CXCL14 Gene

Protein Domains for CXCL14 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CXCL14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95715

UniProtKB/Swiss-Prot:

CXL14_HUMAN :
  • The destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
  • Belongs to the intercrine alpha (chemokine CxC) family.
Domain:
  • The destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL14: view

Function for CXCL14 Gene

Molecular function for CXCL14 Gene

UniProtKB/Swiss-Prot Function:
Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays.
UniProtKB/Swiss-Prot Induction:
Up-regulated in peripheral blood lymphocytes in response to bacterial lipopolysaccharides (LPS).

Gene Ontology (GO) - Molecular Function for CXCL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008009 chemokine activity IEA --
genes like me logo Genes that share ontologies with CXCL14: view
genes like me logo Genes that share phenotypes with CXCL14: view

Animal Models for CXCL14 Gene

MGI Knock Outs for CXCL14:

Animal Model Products

  • Taconic Biosciences Mouse Models for CXCL14

miRNA for CXCL14 Gene

miRTarBase miRNAs that target CXCL14

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CXCL14 Gene

Localization for CXCL14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL14 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXCL14 gene
Compartment Confidence
extracellular 5
golgi apparatus 4
plasma membrane 2
nucleus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CXCL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with CXCL14: view

Pathways & Interactions for CXCL14 Gene

genes like me logo Genes that share pathways with CXCL14: view

Pathways by source for CXCL14 Gene

Gene Ontology (GO) - Biological Process for CXCL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA,TAS 10049774
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 10049774
GO:0007267 cell-cell signaling TAS 10049774
GO:0045662 negative regulation of myoblast differentiation IEA --
genes like me logo Genes that share ontologies with CXCL14: view

No data available for SIGNOR curated interactions for CXCL14 Gene

Transcripts for CXCL14 Gene

mRNA/cDNA for CXCL14 Gene

Unigene Clusters for CXCL14 Gene

Chemokine (C-X-C motif) ligand 14:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL14 Gene

No ASD Table

Relevant External Links for CXCL14 Gene

GeneLoc Exon Structure for
CXCL14
ECgene alternative splicing isoforms for
CXCL14

Expression for CXCL14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CXCL14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CXCL14 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x8.9) and Skin - Not Sun Exposed (Suprapubic) (x7.8).

Protein differential expression in normal tissues from HIPED for CXCL14 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CXCL14 Gene



Protein tissue co-expression partners for CXCL14 Gene

NURSA nuclear receptor signaling pathways regulating expression of CXCL14 Gene:

CXCL14

SOURCE GeneReport for Unigene cluster for CXCL14 Gene:

Hs.483444

mRNA Expression by UniProt/SwissProt for CXCL14 Gene:

O95715-CXL14_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highly expressed in normal tissue without inflammatory stimuli and infrequently expressed in cancer cell lines. Weakly expressed in monocyte-derived dendritic cells. Not detected in lung or unstimulated peripheral blood lymphocytes.
genes like me logo Genes that share expression patterns with CXCL14: view

Primer Products

Orthologs for CXCL14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCL14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXCL14 34 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia CXCL14 34 35
  • 97.53 (n)
dog
(Canis familiaris)
Mammalia CXCL14 34 35
  • 94.28 (n)
mouse
(Mus musculus)
Mammalia Cxcl14 34 16 35
  • 93.98 (n)
rat
(Rattus norvegicus)
Mammalia Cxcl14 34
  • 92.37 (n)
oppossum
(Monodelphis domestica)
Mammalia CXCL14 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CXCL14 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves CXCL14 34
  • 67.5 (n)
JSC 35
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CXCL14 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cxcl14 34
  • 67.47 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24598 34
zebrafish
(Danio rerio)
Actinopterygii cxcl14 34 35
  • 65.06 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2735 34
Species where no ortholog for CXCL14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXCL14 Gene

ENSEMBL:
Gene Tree for CXCL14 (if available)
TreeFam:
Gene Tree for CXCL14 (if available)

Paralogs for CXCL14 Gene

(2) SIMAP similar genes for CXCL14 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CXCL14: view

No data available for Paralogs for CXCL14 Gene

Variants for CXCL14 Gene

Sequence variations from dbSNP and Humsavar for CXCL14 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10042445 -- 135,571,198(+) CATCA(C/T)AGGAT utr-variant-3-prime
rs10054204 -- 135,573,782(+) CAGAC(G/T)CTGCG intron-variant
rs1016666 -- 135,572,712(+) TGGCC(A/G)GAAGC intron-variant
rs1046092 -- 135,571,341(-) ACTCC(A/G)CAGTG utr-variant-3-prime
rs10477771 -- 135,580,245(+) GAACT(A/G)GGACT intron-variant, upstream-variant-2KB

Variation tolerance for CXCL14 Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CXCL14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXCL14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CXCL14 Gene

Disorders for CXCL14 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CXCL14 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
squamous cell carcinoma, head and neck
  • squamous cell carcinoma, head and neck, somatic
pelvic lipomatosis
  • excess of mature unencapsulated fatty tissue in the pelvis
otomycosis
  • singapore ear
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CXCL14

Genetic Association Database (GAD)
CXCL14
Human Genome Epidemiology (HuGE) Navigator
CXCL14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CXCL14
genes like me logo Genes that share disorders with CXCL14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL14 Gene

Publications for CXCL14 Gene

  1. Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in normal versus malignant cells. (PMID: 10049774) Hromas R. … Hou Y.-H. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 22 64
  2. Structural determinants involved in the regulation of CXCL14/BRAK expression by the 26 S proteasome. (PMID: 16987528) Peterson F.C. … Schwarze S.R. (J. Mol. Biol. 2006) 3 4 22 64
  3. In vivo expression of the novel CXC chemokine BRAK in normal and cancerous human tissue. (PMID: 10854217) Frederick M.J. … Clayman G.L. (Am. J. Pathol. 2000) 3 4 22 64
  4. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L. … Crovella S. (Vaccine 2010) 3 46 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for CXCL14 Gene

Sources for CXCL14 Gene

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