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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CXCL14 Gene

protein-coding   GIFtS: 56
GCID: GC05M134934

chemokine (C-X-C motif) ligand 14

(Previous names: small inducible cytokine subfamily B (Cys-X-Cys), member...)
(Previous symbol: SCYB14)
 Explore 25 diseases affiliated with
CXCL14 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CXCL14    

Aliases
for CXCL14 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chemokine (C-X-C Motif) Ligand 141 2     Small-Inducible Cytokine B142 3
SCYB141 2 3 5     MIP2G2 3
NJAC1 2 3     Kec1
BRAK1 2 5     KEC2
BMAC1 2     Breast And Kidney2
KS11 2     C-X-C Motif Chemokine 142
MIP-2g1 2     CXC Chemokine In Breast And Kidney2
Bolekine1     MIP-2 Gamma2
Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 14 (BRAK)1 2     Tumor-Suppressing Chemokine2
Chemokine BRAK2 3     MIP-2G3

External Ids:    HGNC: 106401   Entrez Gene: 95472   Ensembl: ENSG000001458247   OMIM: 6041865   UniProtKB: O957153   

Export aliases for CXCL14 gene to outside databases

Previous GC identifers: GC05M134742 GC05M135617 GC05M134937 GC05M134982 GC05M130094


Summaries
for CXCL14 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CXCL14:
This gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and
inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of
cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This
cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or
macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages
rather than in inflammation. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CXL14_HUMAN, O95715
Function: Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells,
monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony
formation assays




Genomic Views
for CXCL14 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CXCL14 gene promoter:
         RP58   AML1a   HNF-4alpha2   NF-kappaB   HNF-4alpha1   FOXL1   POU2F1   CP2   POU2F1a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CXCL14 promoter sequence
   Search SABiosciences Chromatin IP Primers for CXCL14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCL14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31

CXCL14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCL14 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M134934:  view genomic region     (about GC identifiers)

Start:
 134,906,369 bp from pter      End:
 134,914,969 bp from pter
Size:
 8,601 bases      Orientation:
 minus strand

Proteins
for CXCL14 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CXL14_HUMAN, O95715 (See protein sequence)
Recommended Name: C-X-C motif chemokine 14 precursor  
Size: 111 amino acids; 13078 Da
Subcellular location: Secreted
Caution: It is uncertain whether Met-1 or Met-13 is the initiator
Sequence caution: Sequence=AAD38944.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for CXCL14:
2HDL (3D)    
Secondary accessions: B3KQU8 Q6UW97 Q86U69 Q9BTR1 Q9NS21

Explore the universe of human proteins at neXtProt for CXCL14: NX_O95715

Post-translational modifications:

  • Ubiquitinated, followed by degradation by the proteasome1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95715

    • CXCL14 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004878.2  
    ENSEMBL proteins: 
     ENSP00000423783   ENSP00000337065  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CXCL14 (CXCL14/BRAK)
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: CXCL14
    OriGene Custom Protein Services for CXCL14 
    GenScript Custom Purified and Recombinant Proteins Services for CXCL14
    Novus Biologicals CXCL14 Protein
    Novus Biologicals CXCL14 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CXCL14
    Uscn Proteins for CXCL14

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005794Golgi apparatus IDA--


    CXCL14 for ontologies           About GeneDecksing



    CXCL14 Antibody Products: 
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    Abcam antibodies for CXCL14 
    Uscn Antibodies for CXCL14
    ThermoFisher Antibodies for CXCL14

    Assay Products for CXCL14: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for CXCL14 (CXCL14/BRAK)
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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CXCL14

    Protein Domains /
    Families
    for CXCL14 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CXCL14 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry O95715

    ProtoNet protein and cluster: O95715

    UniProtKB/Swiss-Prot: CXL14_HUMAN, O95715
    Domain: The destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway
    Similarity: Belongs to the intercrine alpha (chemokine CxC) family


    Function
    for CXCL14 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CXL14_HUMAN, O95715
    Function: Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells,
    monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony
    formation assays
    Induction: Up-regulated in peripheral blood lymphocytes in response to bacterial lipopolysaccharides (LPS)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: CXCL14
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCL14
    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL14 (see all 49):
    hsa-miR-142-5p hsa-miR-607 hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-550a* hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmid: CXCL14 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXCL14 (see all 7)
    OriGene shRNA RFP: CXCL14
    OriGene siRNA: CXCL14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCL14

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CXCL14

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL14 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL14
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CXCL14 (NM_004887)
    Sino Biological Human cDNA Clone for CXCL14
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL14 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CXCL14
    Search LifeMap BioReagents cell lines for CXCL14

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL14

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008009chemokine activity IEA--


    CXCL14 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CXCL14:
     Decreased viability with carbo 

    Animal Models:
         Mouse knock-outs for CXCL14: Cxcl14tm1Tha Cxcl14tm1Bmsr
         11 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Cxcl14):
     adipose tissue  behavior/neurological  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  mortality/aging  no phenotypic analysis  renal/urinary system 
     reproductive system 

    CXCL14 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CXCL14 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    8/9 pathways (see all 9)
    		PEDF Induced Signaling1.00
    		RAR-Gamma-RXR-Alpha Degradation0.54
    		MIF Mediated Glucocorticoid Regulation0.73
    		STAT3 Pathway0.47
    		MIF Regulation of Innate Immune Cells0.71
    		Endothelin-1 Signaling Pathway0.44
    		IL-6 Pathway0.61
    		Cytokine-cytokine receptor interaction0.26
    2Rho Family GTPases
    		Rho Family GTPases1.00
    		Molecular Mechanisms of Cancer0.51
    		ERK Signaling0.61
    3PAK Pathway
    		PAK Pathway1.00
    		Antioxidant Action of Vitamin-C0.56
    4Akt Signaling
    		Akt Signaling1.00
    		p38 Signaling0.60
    5Chemokine Signaling
    		Chemokine Signaling1.00
    		Chemokine signaling pathway0.33

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CXCL14 (see all 17)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    MIF Mediated Glucocorticoid Regulation

    1 BioSystems Pathway for CXCL14 
        Senescence and Autophagy


    2         Kegg Pathways  (Kegg details for CXCL14):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway


    CXCL14 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CXCL14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/19 Interacting proteins for CXCL14 (ENSP000003370654) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCR1ENSP000002961404STRING: ENSP00000296140
    CCR10ENSP000003325044STRING: ENSP00000332504
    CCR2ENSP000002923014STRING: ENSP00000292301
    CCR3ENSP000003500034STRING: ENSP00000350003
    CCR4ENSP000003326594STRING: ENSP00000332659
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis IEA--
    GO:0006955immune response IEA--
    GO:0007165signal transduction TAS10049774
    GO:0007267cell-cell signaling TAS10049774
    GO:0048839inner ear development IEA--


    CXCL14 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CXCL14 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CXCL14
    Search CenterWatch for drugs/clinical trials and news about CXCL14 / CXL14 

    Transcripts
    for CXCL14 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CXCL14 gene: 
    NM_004887.4  

    Unigene Cluster for CXCL14:

    Chemokine (C-X-C motif) ligand 14
    Hs.483444  [show with all ESTs]
    Unigene Representative Sequence: NM_004887
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000512158 ENST00000337225(uc003lay.3)

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCL14
    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL14 (see all 49):
    hsa-miR-142-5p hsa-miR-607 hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-550a* hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmid: CXCL14 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXCL14 (see all 7)
    OriGene shRNA RFP: CXCL14
    OriGene siRNA: CXCL14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCL14
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL14 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL14
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CXCL14 (NM_004887)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL14 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CXCL14
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CXCL14
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXCL14
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL14

    Additional cDNA sequence: 

    AB543622.1 AF073957.1 AF086340.1 AF106911.1 AF144103.1 AK075514.1 AY358906.1 BC003513.1 
    BT007080.1 

    16 DOTS entries:

    DT.217947  DT.100790327  DT.113827  DT.101987380  DT.100889248  DT.92467925  DT.100889234  DT.86838770 
    DT.91703153  DT.100790321  DT.100889274  DT.120808082  DT.100032508  DT.120894722  DT.92021274  DT.97863821 

    24/300 AceView cDNA sequences (see all 300):

    AW271559 AI272105 BQ448215 AW612339 AY358906 AI422269 BX106404 BG677521 
    AI143836 BM705787 CB216697 BM712022 BC003513 BF726908 BQ942525 BG740936 
    BM670294 AA368944 BU727767 BM721407 BF434951 AI307640 W73190 AW779779 

    GeneLoc Exon Structure


    Expression
    for CXCL14 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CXCL14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGGTTTCAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CXCL14 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayernGnG Amacrine CellsAmacrine, Retina
    KidneyUreteric BudUreteric Bud Tip CellsKidney
    BoneMandibular ProcessBone
    BoneZeugopod Epiphyseal EndBone
    KidneyRenal VesicleKidney
    KidneyS-shaped BodyKidney
    KidneyUreteric BudKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Trophoblast-like cells (Generation of tropho...)
    Embryoid bodies (Two-step protocol fo...)

    See CXCL14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CXCL14

    SOURCE GeneReport for Unigene cluster: Hs.483444

    UniProtKB/Swiss-Prot: CXL14_HUMAN, O95715
    Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highly
    expressed in normal tissue without inflammatory stimuli and infrequently expressed in cancer cell lines. Weakly
    expressed in monocyte-derived dendritic cells. Not detected in lung or unstimulated peripheral blood lymphocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including CXCL14: 
              Angiogenic Growth Factors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL14
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL14

    Orthologs
    for CXCL14 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CXCL14 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cxcl141 , 5 chemokine (C-X-C motif) ligand 141, 5 94.28(n)1
    94.95(a)1    		   13 (30.06 cM)5
    572661  NM_019568.21  NP_062514.21 
     562886475 
    chicken
    (Gallus gallus)    		 Aves CXCL141 chemokine (C-X-C motif) ligand 14 67.7(n)
    61.86(a)    		   395451  NM_204712.2  NP_990043.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.245982 Xenopus laevis transcribed sequence with weak similarity more 73.07(n)    CD301814.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii cxcl141 chemokine (C-X-C motif) ligand 14 62.54(n)
    54.64(a)    		   58151  NM_131627.1  NP_571702.1 


    ENSEMBL Gene Tree for CXCL14 (if available)
    TreeFam Gene Tree for CXCL14 (if available) 

    Paralogs
    for CXCL14 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for CXCL14 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/162 NCBI SNPs in CXCL14 are shown (see all 162)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1451616051,2
    		--134905913(+) GCATGC/TAAGGC 1 -- ds50010--------
    rs1154367951,2
    		--134906292(+) TTGTCC/TTTATT 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1898217671,2
    		--134906328(+) TTGTCA/GTCCTA 1 -- ds50010--------
    rs1392552831,2
    		C,--134906409(+) ATCTT-/AGAA  
                AGAAT     		1 -- ut310--------
    rs1817166601,2
    		--134906469(+) TATAAC/TACAGC 1 -- ut310--------
    rs1491412721,2
    		--134906484(+) CAATGC/TGGCAT 1 -- ut310--------
    rs1858389791,2
    		--134906500(+) GGGGGA/GCAGTG 1 -- ut310--------
    rs1903461451,2
    		--134906537(+) ATGTAC/TAGAGG 1 -- ut310--------
    rs1433910761,2
    		--134906557(+) ATGGTC/TATCTT 1 -- ut310--------
    rs1159319201,2
    		C,F,--134906636(+) TAGTAC/TTGCAT 1 -- ut311Minor allele frequency- T:0.04WA 118

    HapMap Linkage Disequilibrium report for CXCL14 (134906369 - 134914969 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CXCL14: --

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    Disorders / Diseases
    for CXCL14 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CXCL14 for disorders           About GeneDecksing

    OMIM gene information: 604186    OMIM disorders: --

    20/25 diseases for CXCL14 (see all 25):    About MalaCards
    penile neoplasm    cervical squamous cell carcinoma    paratyphoid fever    squamous cell carcinoma
    papillary thyroid carcinoma    bronchiolitis    neuroendocrine carcinoma    thyroid carcinoma
    hepatitis c    hemangioma    carcinoma    hepatitis b
    cervicitis    prostate cancer    thyroiditis    hepatocellular carcinoma
    ovarian cancer    hepatitis    pancreatic cancer    lung cancer

    1 disease from the University of Copenhagen DISEASES database for CXCL14:
    Penile neoplasm

    6 Novoseek disease relationships for CXCL14 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cervical squamous cell carcinoma 70.1 2 10854217 (1), 15843547 (1)
    hnscc 65.6 9 15843547 (3), 19673887 (2), 10854217 (1)
    carcinoma squamous cell 36.1 8 19673887 (2), 15843547 (1), 15548693 (1)
    tumors 25 36 15651028 (4), 19673887 (4), 15548693 (3), 10854217 (2) (see all 6)
    prostate cancer 24.6 7 15651028 (3), 20460540 (2)
    cancer 20 10 15651028 (2), 10854217 (2), 16987528 (2), 20460540 (1) (see all 5)

    Genetic Association Database (GAD): CXCL14
    Human Genome Epidemiology (HuGE) Navigator: CXCL14 (13 documents)

    Export disorders for CXCL14 gene to outside databases

    Publications
    for CXCL14 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CXCL14 gene, integrated from 9 sources (see all 60):
    (articles sorted by number of sources associating them with CXCL14)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in normal versus malignant cells. (PubMed id 10049774)1, 2, 3, 9 Hromas R.... Hou Y.-H. (1999)
    2. In vivo expression of the novel CXC chemokine BRAK in normal and cancerous human tissue. (PubMed id 10854217)1, 2, 9 Frederick M.J.... Clayman G.L. (2000)
    3. Structural determinants involved in the regulation of CXCL14/BRAK expression by the 26 S proteasome. (PubMed id 16987528)1, 2, 9 Peterson F.C....Schwarze S.R. (2006)
    4. Large-scale search of single nucleotide polymorphisms for hepatocellular carcinoma susceptibility genes in patients with hepatitis C. (PubMed id 16175604)1, 4 Kato N....Omata M. (2005)
    5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    8. Molecular cloning and characterization of a novel CXC chemokine macrophage inflammatory protein-2 gamma chemoattractant for human neutrophils and dendritic cells. (PubMed id 10946286)1, 2 Cao X....Chen G. (2000)
    9. Modulation of CXCL14 (BRAK) expression in prostate cancer. (PubMed id 15651028)1, 9 Schwarze S.R....Jarrard D.F. (2005)
    10. BRAK/CXCL14 is a potent inhibitor of angiogenesis and a chemotactic factor for immature dendritic cells. (PubMed id 15548693)1, 9 Shellenberger T.D....Frederick M.J. (2004)

    External Searches for CXCL14 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CXCL14 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9547 HGNC: 10640 AceView: CXCL14 Ensembl:ENSG00000145824 euGenes: HUgn9547
    ECgene: CXCL14 Kegg: 9547 H-InvDB: CXCL14

    Other Databases showing CXCL14 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CXCL14 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CXCL14 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CXCL14

    Intellectual Property
    for CXCL14 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CXCL14 gene:
    Search GeneIP for patents involving CXCL14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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