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CXCL14 Gene

protein-coding   GIFtS: 52
GCID: GC05M134934

Chemokine (C-X-C Motif) Ligand 14

(Previous names: small inducible cytokine subfamily B (Cys-X-Cys), member...)
(Previous symbol: SCYB14)
  See CXCL14-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-X-C Motif) Ligand 141 2     KEC2
SCYB141 2 3 5     KS12
Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 14 (BRAK)1 2     MIP-2g2
Breast And Kidney1 2     bolekine2
Chemokine BRAK2 3     C-X-C Motif Chemokine 142
Small-Inducible Cytokine B142 3     CXC Chemokine In Breast And Kidney2
MIP2G2 3     MIP-2 Gamma2
NJAC2 3     Tumor-Suppressing Chemokine2
BRAK2 5     MIP-2G3
BMAC2     

External Ids:    HGNC: 106401   Entrez Gene: 95472   Ensembl: ENSG000001458247   OMIM: 6041865   UniProtKB: O957153   

Export aliases for CXCL14 gene to outside databases

Previous GC identifers: GC05M134742 GC05M135617 GC05M134937 GC05M134982 GC05M130094


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CXCL14 Gene:
This gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and
inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily
of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This
cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or
macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived
macrophages rather than in inflammation. (provided by RefSeq, Jul 2008)

GeneCards Summary for CXCL14 Gene:
CXCL14 (chemokine (C-X-C motif) ligand 14) is a protein-coding gene. Diseases associated with CXCL14 include penile neoplasm, and papillary thyroid carcinoma. GO annotations related to this gene include chemokine activity.

UniProtKB/Swiss-Prot: CXL14_HUMAN, O95715
Function: Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells,
B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors
in colony formation assays




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the CXCL14 gene promoter:
         RP58   AML1a   HNF-4alpha2   NF-kappaB   HNF-4alpha1   FOXL1   POU2F1   CP2   POU2F1a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXCL14 promoter sequence
   Search Chromatin IP Primers for CXCL14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CXCL14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31

CXCL14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCL14 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M134934:  view genomic region     (about GC identifiers)

Start:
134,906,369 bp from pter      End:
134,914,969 bp from pter
Size:
8,601 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CXL14_HUMAN, O95715 (See protein sequence)
Recommended Name: C-X-C motif chemokine 14 precursor  
Size: 111 amino acids; 13078 Da
Caution: It is uncertain whether Met-1 or Met-13 is the initiator
Sequence caution: Sequence=AAD38944.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for CXCL14:
2HDL (3D)    
Secondary accessions: B3KQU8 Q6UW97 Q86U69 Q9BTR1 Q9NS21

Explore the universe of human proteins at neXtProt for CXCL14: NX_O95715

Explore proteomics data for CXCL14 at MOPED

Post-translational modifications: 

  • Ubiquitinated, followed by degradation by the proteasome1
  • Modification sites at neXtProt

  • See CXCL14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004878.2  
    ENSEMBL proteins: 
     ENSP00000423783   ENSP00000337065  

    CXCL14 Human Recombinant Protein Products:

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    Novus Biologicals CXCL14 Lysate
    Sino Biological Recombinant Protein for CXCL14
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CXCL14
    Browse Proteins at Cloud-Clone Corp.

     
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    CXCL14 Antibody Products:

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    Search eBioscience for ELISAs for CXCL14 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry O95715

    ProtoNet protein and cluster: O95715

    UniProtKB/Swiss-Prot: CXL14_HUMAN, O95715
    Domain: The destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome
    pathway
    Similarity: Belongs to the intercrine alpha (chemokine CxC) family


    Find genes that share domains with CXCL14           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CXL14_HUMAN, O95715
    Function: Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells,
    B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors
    in colony formation assays
    Induction: Up-regulated in peripheral blood lymphocytes in response to bacterial lipopolysaccharides (LPS)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008009chemokine activity IEA--
         
    Find genes that share ontologies with CXCL14           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CXCL14:
     Decreased viability with carbo 

         11 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Cxcl14):
     adipose tissue  behavior/neurological  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  mortality/aging  no phenotypic analysis  renal/urinary system 
     reproductive system 

    Find genes that share phenotypes with CXCL14           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CXCL14: Cxcl14tm1Tha Cxcl14tm1.1Rih Cxcl14tm1Bmsr

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CXCL14
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CXCL14

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CXCL14
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CXCL14

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CXCL14 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CXCL14 (see all 49):
    hsa-miR-142-5p hsa-miR-607 hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-550a* hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidCXCL14 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CXCL14
    Predesigned siRNA for gene silencing in human, mouse, rat CXCL14

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: CXCL14 (NM_004887)
    Sino Biological Human cDNA Clone for CXCL14
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL14

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    Browse ESI BIO Cell Lines and PureStem Progenitors for CXCL14 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL14


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CXL14_HUMAN, O95715: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    golgi apparatus4
    plasma membrane2
    cytosol1
    lysosome1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--
    GO:0005794Golgi apparatus IDA--

    Find genes that share ontologies with CXCL14           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CXCL14 About   (see all 8)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    IL-6 Pathway0.61
    MIF Mediated Glucocorticoid Regulation0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43
    2Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    3ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    4Akt Signaling
    Akt Signaling0.60
    p38 Signaling0.60
    5PAK Pathway
    PAK Pathway0.56
    Antioxidant Action of Vitamin-C0.56


    Find genes that share SuperPaths with CXCL14           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CXCL14
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CXCL14 (see all 17)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    MIF Mediated Glucocorticoid Regulation

    1 BioSystems Pathway for CXCL14
        Senescence and Autophagy



    2 Kegg Pathways  (Kegg details for CXCL14):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CXCL14: 
              Angiogenic Growth Factors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CXCL14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for CXCL14 (O957152 ENSP000003370654) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CXCR4P610732, ENSP000003868844MINT-8427972 STRING: ENSP00000386884
    CCR1ENSP000002961404STRING: ENSP00000296140
    CCR10ENSP000003325044STRING: ENSP00000332504
    CCR2ENSP000002923014STRING: ENSP00000292301
    CCR3ENSP000003500034STRING: ENSP00000350003
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis TAS10049774
    GO:0006955immune response IEA--
    GO:0007165signal transduction TAS10049774
    GO:0007267cell-cell signaling TAS10049774
    GO:0048839inner ear development IEA--

    Find genes that share ontologies with CXCL14           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CXCL14 (CXL14)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CXCL14 gene: 
    NM_004887.4  

    Unigene Cluster for CXCL14:

    Chemokine (C-X-C motif) ligand 14
    Hs.483444  [show with all ESTs]
    Unigene Representative Sequence: NM_004887
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000512158 ENST00000337225(uc003lay.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CXCL14 (see all 49):
    hsa-miR-142-5p hsa-miR-607 hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-550a* hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidCXCL14 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CXCL14
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    GenScript: all cDNA clones in your preferred vector: CXCL14 (NM_004887)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL14
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    Primer
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    OriGene qPCR primer pairs and template standards for CXCL14
    OriGene qSTAR qPCR primer pairs in human, mouse for CXCL14
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CXCL14
      QuantiTect SYBR Green Assays in human, mouse, rat CXCL14
      QuantiFast Probe-based Assays in human, mouse, rat CXCL14

    Additional mRNA sequence: 

    AB543622.1 AF073957.1 AF086340.1 AF106911.1 AF144103.1 AK075514.1 AY358906.1 BC003513.1 
    BT007080.1 

    16 DOTS entries:

    DT.217947  DT.100790327  DT.113827  DT.101987380  DT.100889248  DT.92467925  DT.100889234  DT.86838770 
    DT.100790321  DT.100889274  DT.120808082  DT.91703153  DT.100032508  DT.120894722  DT.92021274  DT.97863821 

    Selected AceView cDNA sequences (see all 300):

    BM694795 AA331237 BM700201 BU734826 W84568 AI942296 AI905185 AF086340 
    AI143836 AI272105 AW271559 AK075514 BU727842 BG677005 AI634020 BP339151 
    BM705787 BX106404 BT007080 BG696197 CB216697 AI222528 BG740936 BF588509 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CXCL14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGTTTCAT
    CXCL14 Expression
    About this image


    CXCL14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Ureteric Bud Tip Cells Ureteric Bud
             Renal Vesicle
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Vascular endothelial growth factor-induced embryoid bodies
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mandibular Process
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Limb (Muscoskeletal System)
             Limb Bud
    CXCL14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CXCL14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.483444

    UniProtKB/Swiss-Prot: CXL14_HUMAN, O95715
    Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highly
    expressed in normal tissue without inflammatory stimuli and infrequently expressed in cancer cell lines. Weakly
    expressed in monocyte-derived dendritic cells. Not detected in lung or unstimulated peripheral blood lymphocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CXCL14: 
              Angiogenic Growth Factors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CXCL14
    OriGene qSTAR qPCR primer pairs in human, mouse for CXCL14
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CXCL14
    QuantiTect SYBR Green Assays in human, mouse, rat CXCL14
    QuantiFast Probe-based Assays in human, mouse, rat CXCL14
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CXCL14 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cxcl141 , 5 chemokine (C-X-C motif) ligand 141, 5 93.98(n)1
    95.18(a)1
      13 (30.06 cM)5
    572661  NM_019568.21  NP_062514.21 
     562886475 
    chicken
    (Gallus gallus)
    Aves CXCL141 chemokine (C-X-C motif) ligand 14 67.5(n)
    62.5(a)
      395451  NM_204712.2  NP_990043.1 
    lizard
    (Anolis carolinensis)
    Reptilia CXCL146
    chemokine (C-X-C motif) ligand 14
    61(a)
    1 ↔ 1
    GL343223.1(1126942-1146713)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.245982 Xenopus laevis transcribed sequence with weak similarity more 73.07(n)    CD301814.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cxcl141 chemokine (C-X-C motif) ligand 14 65.06(n)
    55.42(a)
      58151  NM_131627.1  NP_571702.1 


    ENSEMBL Gene Tree for CXCL14 (if available)
    TreeFam Gene Tree for CXCL14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for CXCL14 gene
    2 SIMAP similar genes for CXCL14 using alignment to 1 protein entry:     CXL14_HUMAN:
    CXCL2    CXCL3

    Find genes that share paralogs with CXCL14           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CXCL14 (see all 215)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1451616051,2
    C--134905913(+) GCATGC/TAAGGC 1 -- ds50010--------
    rs1154367951,2
    F--134906292(+) TTGTCC/TTTATT 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1898217671,2
    C--134906328(+) TTGTCA/GTCCTA 1 -- ds50010--------
    rs1392552831,2
    C--134906409(+) ATCTT-/AGAA  
            
    AGAAT
    1 -- ut310--------
    rs1817166601,2
    --134906469(+) TATAAC/TACAGC 1 -- ut310--------
    rs1491412721,2
    C--134906484(+) CAATGC/TGGCAT 1 -- ut310--------
    rs1858389791,2
    --134906500(+) GGGGGA/GCAGTG 1 -- ut310--------
    rs1903461451,2
    --134906537(+) ATGTAC/TAGAGG 1 -- ut310--------
    rs1433910761,2
    C--134906557(+) ATGGTC/TATCTT 1 -- ut310--------
    rs1159319201,2
    C,F--134906636(+) TAGTAC/TTGCAT 1 -- ut311Minor allele frequency- T:0.04WA 118

    HapMap Linkage Disequilibrium report for CXCL14 (134906369 - 134914969 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CXCL14: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CXCL14
    DNA2.0 Custom Variant and Variant Library Synthesis for CXCL14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604186    OMIM disorders: --

    2 diseases for CXCL14:    
    About MalaCards
    penile neoplasm    papillary thyroid carcinoma

    1 disease from the University of Copenhagen DISEASES database for CXCL14:
    Penile neoplasm

    Find genes that share disorders with CXCL14           About GenesLikeMe

    6 Novoseek inferred disease relationships for CXCL14 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cervical squamous cell carcinoma 70.1 2 10854217 (1), 15843547 (1)
    hnscc 65.6 9 15843547 (3), 19673887 (2), 10854217 (1)
    carcinoma squamous cell 36.1 8 19673887 (2), 15843547 (1), 15548693 (1)
    tumors 25 36 15651028 (4), 19673887 (4), 15548693 (3), 10854217 (2) (see all 6)
    prostate cancer 24.6 7 15651028 (3), 20460540 (2)
    cancer 20 10 15651028 (2), 10854217 (2), 16987528 (2), 20460540 (1) (see all 5)

    Genetic Association Database (GAD): CXCL14
    Human Genome Epidemiology (HuGE) Navigator: CXCL14 (13 documents)

    Export disorders for CXCL14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CXCL14 gene, integrated from 10 sources (see all 66):
    (articles sorted by number of sources associating them with CXCL14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in normal versus malignant cells. (PubMed id 10049774)1, 2, 3, 9 Hromas R.... Hou Y.-H. (Biochem. Biophys. Res. Commun. 1999)
    2. In vivo expression of the novel CXC chemokine BRAK in normal and cancerous human tissue. (PubMed id 10854217)1, 2, 9 Frederick M.J.... Clayman G.L. (Am. J. Pathol. 2000)
    3. Structural determinants involved in the regulation of CXCL14/BRAK expression by the 26 S proteasome. (PubMed id 16987528)1, 2, 9 Peterson F.C.... Schwarze S.R. (J. Mol. Biol. 2006)
    4. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    5. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    6. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    9. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    10. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9547 HGNC: 10640 AceView: CXCL14 Ensembl:ENSG00000145824 euGenes: HUgn9547
    ECgene: CXCL14 Kegg: 9547 H-InvDB: CXCL14

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CXCL14 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CXCL14

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CXCL14 gene:
    Search GeneIP for patents involving CXCL14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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