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Aliases for CXCL14 Gene

Aliases for CXCL14 Gene

  • Chemokine (C-X-C Motif) Ligand 14 2 3
  • SCYB14 3 4 6
  • Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 14 (BRAK) 2 3
  • Small-Inducible Cytokine B14 3 4
  • Breast And Kidney 2 3
  • Chemokine BRAK 3 4
  • MIP-2g 3 4
  • MIP2G 3 4
  • BRAK 3 6
  • NJAC 3 4
  • CXC Chemokine In Breast And Kidney 3
  • Tumor-Suppressing Chemokine 3
  • C-X-C Motif Chemokine 14 3
  • MIP-2 Gamma 3
  • Bolekine 3
  • BMAC 3
  • KS1 3
  • KEC 3

External Ids for CXCL14 Gene

Previous Symbols for CXCL14 Gene

  • SCYB14

Summaries for CXCL14 Gene

Entrez Gene Summary for CXCL14 Gene

  • This antimicrobial gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. [provided by RefSeq, Sep 2014]

GeneCards Summary for CXCL14 Gene

CXCL14 (Chemokine (C-X-C Motif) Ligand 14) is a Protein Coding gene. Diseases associated with CXCL14 include penile neoplasm. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include chemokine activity.

UniProtKB/Swiss-Prot for CXCL14 Gene

  • Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL14 Gene

Genomics for CXCL14 Gene

Genomic Location for CXCL14 Gene

Start:
135,570,679 bp from pter
End:
135,579,279 bp from pter
Size:
8,601 bases
Orientation:
Minus strand

Genomic View for CXCL14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CXCL14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL14 Gene

Regulatory Elements for CXCL14 Gene

Proteins for CXCL14 Gene

  • Protein details for CXCL14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95715-CXL14_HUMAN
    Recommended name:
    C-X-C motif chemokine 14
    Protein Accession:
    O95715
    Secondary Accessions:
    • B3KQU8
    • Q6UW97
    • Q86U69
    • Q9BTR1
    • Q9NS21

    Protein attributes for CXCL14 Gene

    Size:
    111 amino acids
    Molecular mass:
    13078 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD38944.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CXCL14 Gene

neXtProt entry for CXCL14 Gene

Proteomics data for CXCL14 Gene at MOPED

Post-translational modifications for CXCL14 Gene

Other Protein References for CXCL14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CXCL14 Gene

Domains for CXCL14 Gene

Protein Domains for CXCL14 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CXCL14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95715

UniProtKB/Swiss-Prot:

CXL14_HUMAN
Domain:
  • The destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.:
    • O95715
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.:
    • O95715
genes like me logo Genes that share domains with CXCL14: view

No data available for Gene Families for CXCL14 Gene

Function for CXCL14 Gene

Molecular function for CXCL14 Gene

UniProtKB/Swiss-Prot Function: Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays.
UniProtKB/Swiss-Prot Induction: Up-regulated in peripheral blood lymphocytes in response to bacterial lipopolysaccharides (LPS).

Gene Ontology (GO) - Molecular Function for CXCL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008009 chemokine activity IEA --
genes like me logo Genes that share ontologies with CXCL14: view
genes like me logo Genes that share phenotypes with CXCL14: view

Animal Models for CXCL14 Gene

MGI Knock Outs for CXCL14:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CXCL14 Gene

Localization for CXCL14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL14 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CXCL14 Gene COMPARTMENTS Subcellular localization image for CXCL14 gene
Compartment Confidence
extracellular 5
golgi apparatus 4
plasma membrane 2
cytosol 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CXCL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with CXCL14: view

Pathways for CXCL14 Gene

genes like me logo Genes that share pathways with CXCL14: view

Pathways by source for CXCL14 Gene

Gene Ontology (GO) - Biological Process for CXCL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis TAS 10049774
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 10049774
GO:0007267 cell-cell signaling TAS 10049774
GO:0045662 negative regulation of myoblast differentiation IEA --
genes like me logo Genes that share ontologies with CXCL14: view

Transcripts for CXCL14 Gene

mRNA/cDNA for CXCL14 Gene

Unigene Clusters for CXCL14 Gene

Chemokine (C-X-C motif) ligand 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL14 Gene

No ASD Table

Relevant External Links for CXCL14 Gene

GeneLoc Exon Structure for
CXCL14
ECgene alternative splicing isoforms for
CXCL14

Expression for CXCL14 Gene

mRNA expression in normal human tissues for CXCL14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CXCL14 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (8.9) and Skin - Not Sun Exposed (Suprapubic) (7.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CXCL14 Gene

SOURCE GeneReport for Unigene cluster for CXCL14 Gene Hs.483444

mRNA Expression by UniProt/SwissProt for CXCL14 Gene

O95715-CXL14_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highly expressed in normal tissue without inflammatory stimuli and infrequently expressed in cancer cell lines. Weakly expressed in monocyte-derived dendritic cells. Not detected in lung or unstimulated peripheral blood lymphocytes.
genes like me logo Genes that share expressions with CXCL14: view

Orthologs for CXCL14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCL14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXCL14 35
  • 100 (n)
  • 100 (a)
CXCL14 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CXCL14 35
  • 97.53 (n)
  • 98.77 (a)
CXCL14 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CXCL14 35
  • 94.28 (n)
  • 96.97 (a)
CXCL14 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cxcl14 35
  • 93.98 (n)
  • 95.18 (a)
Cxcl14 16
Cxcl14 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CXCL14 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CXCL14 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cxcl14 35
  • 92.37 (n)
  • 96.39 (a)
chicken
(Gallus gallus)
Aves CXCL14 35
  • 67.5 (n)
  • 62.5 (a)
JSC 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CXCL14 36
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24598 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cxcl14 35
  • 67.47 (n)
  • 68.67 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2735 35
zebrafish
(Danio rerio)
Actinopterygii cxcl14 35
  • 65.06 (n)
  • 55.42 (a)
cxcl14 36
  • 53 (a)
OneToOne
Species with no ortholog for CXCL14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXCL14 Gene

ENSEMBL:
Gene Tree for CXCL14 (if available)
TreeFam:
Gene Tree for CXCL14 (if available)

Paralogs for CXCL14 Gene

Selected SIMAP similar genes for CXCL14 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CXCL14: view

No data available for Paralogs for CXCL14 Gene

Variants for CXCL14 Gene

Sequence variations from dbSNP and Humsavar for CXCL14 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs2547 -- 135,571,862(+) TCTTC(A/G)TAGAC reference, synonymous-codon
rs7666 -- 135,570,955(-) CAACA(G/T)AACAT utr-variant-3-prime
rs245114 -- 135,571,451(+) AGCAA(C/T)ACTGC utr-variant-3-prime
rs245115 -- 135,571,890(+) CATGT(A/G)TAAGT intron-variant
rs1016666 -- 135,572,712(+) TGGCC(A/G)GAAGC intron-variant

Relevant External Links for CXCL14 Gene

HapMap Linkage Disequilibrium report
CXCL14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CXCL14 Gene

Disorders for CXCL14 Gene

(1) MalaCards Diseases for CXCL14 Gene

Search for CXCL14 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CXCL14 Gene

(6) Novoseek inferred disease relationships for CXCL14 Gene

Disease -log(P) Hits PubMed IDs
cervical squamous cell carcinoma 70.1 2
hnscc 65.6 6
carcinoma squamous cell 36.1 4
tumors 25 16
prostate cancer 24.6 5

Relevant External Links for CXCL14

Genetic Association Database (GAD)
CXCL14
Human Genome Epidemiology (HuGE) Navigator
CXCL14
genes like me logo Genes that share disorders with CXCL14: view

No data available for UniProtKB/Swiss-Prot for CXCL14 Gene

Publications for CXCL14 Gene

  1. Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in normal versus malignant cells. (PMID: 10049774) Hromas R. … Hou Y.-H. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23
  2. In vivo expression of the novel CXC chemokine BRAK in normal and cancerous human tissue. (PMID: 10854217) Frederick M.J. … Clayman G.L. (Am. J. Pathol. 2000) 3 4 23
  3. Structural determinants involved in the regulation of CXCL14/BRAK expression by the 26 S proteasome. (PMID: 16987528) Peterson F.C. … Schwarze S.R. (J. Mol. Biol. 2006) 3 4 23
  4. Molecular cloning and characterization of a novel CXC chemokine macrophage inflammatory protein-2 gamma chemoattractant for human neutrophils and dendritic cells. (PMID: 10946286) Cao X. … Chen G. (J. Immunol. 2000) 3 4
  5. BRAK/CXCL14 is a potent inhibitor of angiogenesis and a chemotactic factor for immature dendritic cells. (PMID: 15548693) Shellenberger T.D. … Frederick M.J. (Cancer Res. 2004) 3 23

Products for CXCL14 Gene

Sources for CXCL14 Gene

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