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Aliases for CXCL13 Gene

Aliases for CXCL13 Gene

  • Chemokine (C-X-C Motif) Ligand 13 2 3
  • SCYB13 3 4 6
  • BCA1 3 4 6
  • BLC 3 4 6
  • Small Inducible Cytokine B Subfamily (Cys-X-Cys Motif), Member 13 (B-Cell Chemoattractant) 2 3
  • B Cell-Attracting Chemokine 1 3 4
  • B Lymphocyte Chemoattractant 3 4
  • Small-Inducible Cytokine B13 3 4
  • B-Cell Chemoattractant 2 3
  • CXC Chemokine BLC 3 4
  • ANGIE 3 4
  • BCA-1 3 4
  • B-Cell-Homing Chemokine (Ligand For Burkitts Lymphoma Receptor-1) 3
  • Chemokine (C-X-C Motif) Ligand 13 (B-Cell Chemoattractant) 3
  • B-Cell-Attracting Chemokine 1 3
  • B-Lymphocyte Chemoattractant 3
  • C-X-C Motif Chemokine 13 3
  • ANGIE2 3
  • BLR1L 3

External Ids for CXCL13 Gene

Previous HGNC Symbols for CXCL13 Gene

  • SCYB13

Previous GeneCards Identifiers for CXCL13 Gene

  • GC04P078343
  • GC04P078623
  • GC04P078825
  • GC04P078891
  • GC04P078866
  • GC04P078790
  • GC04P074184

Summaries for CXCL13 Gene

Entrez Gene Summary for CXCL13 Gene

  • B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. [provided by RefSeq, Oct 2014]

GeneCards Summary for CXCL13 Gene

CXCL13 (Chemokine (C-X-C Motif) Ligand 13) is a Protein Coding gene. Diseases associated with CXCL13 include thymic hyperplasia and follicular dendritic cell sarcoma. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include protein heterodimerization activity and chemokine activity.

UniProtKB/Swiss-Prot for CXCL13 Gene

  • Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5

Gene Wiki entry for CXCL13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL13 Gene

Genomics for CXCL13 Gene

Regulatory Elements for CXCL13 Gene

Genomic Location for CXCL13 Gene

Start:
77,511,753 bp from pter
End:
77,611,834 bp from pter
Size:
100,082 bases
Orientation:
Plus strand

Genomic View for CXCL13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CXCL13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL13 Gene

Proteins for CXCL13 Gene

  • Protein details for CXCL13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43927-CXL13_HUMAN
    Recommended name:
    C-X-C motif chemokine 13
    Protein Accession:
    O43927
    Secondary Accessions:

    Protein attributes for CXCL13 Gene

    Size:
    109 amino acids
    Molecular mass:
    12664 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CXCL13 Gene

Proteomics data for CXCL13 Gene at MOPED

Post-translational modifications for CXCL13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CXCL13 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CXCL13 Gene

Domains for CXCL13 Gene

Gene Families for CXCL13 Gene

HGNC:

Protein Domains for CXCL13 Gene

Suggested Antigen Peptide Sequences for CXCL13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43927

UniProtKB/Swiss-Prot:

CXL13_HUMAN :
  • O43927
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL13: view

Function for CXCL13 Gene

Molecular function for CXCL13 Gene

UniProtKB/Swiss-Prot Function: Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5

Gene Ontology (GO) - Molecular Function for CXCL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008009 chemokine activity IDA 11554781
GO:0008201 heparin binding IDA 11708770
GO:0017134 fibroblast growth factor binding IDA 11708770
GO:0031724 CXCR5 chemokine receptor binding IDA 9463416
GO:0031735 CCR10 chemokine receptor binding IDA 10706668
genes like me logo Genes that share ontologies with CXCL13: view

Phenotypes for CXCL13 Gene

genes like me logo Genes that share phenotypes with CXCL13: view

Animal Models for CXCL13 Gene

MGI Knock Outs for CXCL13:

miRNA for CXCL13 Gene

miRTarBase miRNAs that target CXCL13

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CXCL13 Gene

Localization for CXCL13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL13 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CXCL13 Gene COMPARTMENTS Subcellular localization image for CXCL13 gene
Compartment Confidence
extracellular 5
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CXCL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with CXCL13: view

Pathways for CXCL13 Gene

genes like me logo Genes that share pathways with CXCL13: view

Pathways by source for CXCL13 Gene

Gene Ontology (GO) - Biological Process for CXCL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002467 germinal center formation NAS 16543475
GO:0002518 lymphocyte chemotaxis across high endothelial venule ISS --
GO:0002544 chronic inflammatory response NAS 15284119
GO:0002920 regulation of humoral immune response NAS 16531331
GO:0006954 inflammatory response IBA --
genes like me logo Genes that share ontologies with CXCL13: view

Compounds for CXCL13 Gene

(1) HMDB Compounds for CXCL13 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(3) Novoseek inferred chemical compound relationships for CXCL13 Gene

Compound -log(P) Hits PubMed IDs
teck 83.4 3
peg-10 72.5 4
calcium 0 4
genes like me logo Genes that share compounds with CXCL13: view

Transcripts for CXCL13 Gene

mRNA/cDNA for CXCL13 Gene

Unigene Clusters for CXCL13 Gene

Chemokine (C-X-C motif) ligand 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL13 Gene

No ASD Table

Relevant External Links for CXCL13 Gene

GeneLoc Exon Structure for
CXCL13
ECgene alternative splicing isoforms for
CXCL13

Expression for CXCL13 Gene

mRNA expression in normal human tissues for CXCL13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CXCL13 Gene

This gene is overexpressed in Spleen (38.1) and Small Intestine - Terminal Ileum (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CXCL13 Gene

SOURCE GeneReport for Unigene cluster for CXCL13 Gene Hs.100431

mRNA Expression by UniProt/SwissProt for CXCL13 Gene

O43927-CXL13_HUMAN
Tissue specificity: Highest levels in liver, followed by spleen, lymph node, appendix and stomach. Low levels in salivary gland, mammary gland and fetal spleen
genes like me logo Genes that share expressions with CXCL13: view

Orthologs for CXCL13 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CXCL13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXCL13 35
  • 99.69 (n)
  • 99.08 (a)
CXCL13 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CXCL13 35
  • 72.59 (n)
  • 51.4 (a)
CXCL13 36
  • 50 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CXCL13 35
  • 75.62 (n)
  • 56.48 (a)
CXCL13 36
  • 55 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cxcl13 35
  • 64.04 (n)
  • 44.94 (a)
Cxcl13 16
Cxcl13 36
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cxcl13 35
  • 67.04 (n)
  • 43.82 (a)
Species with no ortholog for CXCL13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL13 Gene

ENSEMBL:
Gene Tree for CXCL13 (if available)
TreeFam:
Gene Tree for CXCL13 (if available)

Paralogs for CXCL13 Gene

Selected SIMAP similar genes for CXCL13 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CXCL13: view

No data available for Paralogs for CXCL13 Gene

Variants for CXCL13 Gene

Sequence variations from dbSNP and Humsavar for CXCL13 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs11868 -- 77,611,735(-) CACAA(A/G)AAAAG utr-variant-3-prime
rs168539 -- 77,561,921(+) cgccc(A/C)gtgct intron-variant
rs171388 -- 77,600,371(+) GATAT(C/T)AAGGG intron-variant
rs183061 -- 77,596,582(+) gagtt(A/C)gagac intron-variant
rs184807 -- 77,571,644(+) tgccc(C/T)gacaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CXCL13 Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER Inversion 18451855
nsv829975 CNV Gain 17160897
esv2669104 CNV Deletion 23128226
esv29506 CNV Loss 19812545
nsv4395 CNV Insertion 18451855

Relevant External Links for CXCL13 Gene

HapMap Linkage Disequilibrium report
CXCL13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL13 Gene

Disorders for CXCL13 Gene

(2) University of Copenhagen DISEASES for CXCL13 Gene

(18) Novoseek inferred disease relationships for CXCL13 Gene

Disease -log(P) Hits PubMed IDs
angioimmunoblastic t-cell lymphoma 72.9 8
lymphoid hyperplasia 53.8 4
sjogrens syndrome 51.7 4
lymphoma t-cell peripheral 49.4 5
b-all 48.4 5

Relevant External Links for CXCL13

Genetic Association Database (GAD)
CXCL13
Human Genome Epidemiology (HuGE) Navigator
CXCL13
genes like me logo Genes that share disorders with CXCL13: view

No data available for UniProtKB/Swiss-Prot for CXCL13 Gene

Publications for CXCL13 Gene

  1. B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. (PMID: 9463416) Legler D.F. … Moser B. (J. Exp. Med. 1998) 2 3 4 23
  2. A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. (PMID: 9486651) Gunn M.D. … Williams L.T. (Nature 1998) 2 3 4 23
  3. Expression of B-cell-attracting chemokine 1 (CXCL13) by malignant lymphocytes and vascular endothelium in primary central nervous system lymphoma. (PMID: 12393412) Smith J.R. … Rosenbaum J.T. (Blood 2003) 3 23
  4. CXCL13 (BCA-1) is produced by follicular lymphoma cells: role in the accumulation of malignant B cells. (PMID: 12406091) Husson H. … Ghia P. (Br. J. Haematol. 2002) 3 23
  5. BCR ligation reprograms B cells for migration to the T zone and B-cell follicle sequentially. (PMID: 11877260) Casamayor-PallejA M. … Defrance T. (Blood 2002) 3 23

Products for CXCL13 Gene

Sources for CXCL13 Gene

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