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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CXCL13 Gene

protein-coding   GIFtS: 64
GCID: GC04P078343

chemokine (C-X-C motif) ligand 13

(Previous names: small inducible cytokine B subfamily (Cys-X-Cys motif),...)
(Previous symbol: SCYB13)
 Explore 60 diseases affiliated with
CXCL13 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CXCL13    

Aliases
for CXCL13 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chemokine (C-X-C Motif) Ligand 131 2     B Lymphocyte Chemoattractant2 3
BLC1 2 3 5     Small-Inducible Cytokine B132 3
SCYB131 2 3 5     CXC Chemokine BLC2 3
BCA-11 2 3     B-Cell Chemoattractant2
BCA12 3 5     B-Cell-Attracting Chemokine 12
ANGIE1 2     B-Cell-Homing Chemokine (Ligand For Burkitt'S Lymphoma Receptor-1)2
ANGIE21 2     B-Lymphocyte Chemoattractant2
BLR1L1 2     C-X-C Motif Chemokine 132
Small Inducible Cytokine B Subfamily (Cys-X-Cys Motif), Member 13 (B-Cell
Chemoattractant)1 2
     Chemokine (C-X-C Motif) Ligand 13 (B-Cell Chemoattractant)2
B Cell-Attracting Chemokine 12 3     Angie3

External Ids:    HGNC: 106391   Entrez Gene: 105632   Ensembl: ENSG000001562347   OMIM: 6051495   UniProtKB: O439273   

Export aliases for CXCL13 gene to outside databases

Previous GC identifers: GC04P078623 GC04P078825 GC04P078891 GC04P078866 GC04P078790 GC04P074184


Summaries
for CXCL13 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CXCL13:
B lymphocyte chemoattractant, independently cloned and named Angie, is a CXC chemokine strongly expressed in the
follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes
(compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells
expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to
follicles. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CXL13_HUMAN, O43927
Function: Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium
release in B-lymphocytes. Binds to BLR1/CXCR5

Gene Wiki entry for CXCL13


Genomic Views
for CXCL13 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CXCL13 gene promoter:
         ISGF-3   Nkx2-2   Evi-1   RORalpha1   PPAR-gamma1   POU2F1   POU2F1a   IRF-7A   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CXCL13 promoter sequence
   Search SABiosciences Chromatin IP Primers for CXCL13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCL13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q21.1   HGNC cytogenetic band: 4q21

CXCL13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCL13 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P078343:  view genomic region     (about GC identifiers)

Start:
 78,432,907 bp from pter      End:
 78,532,988 bp from pter
Size:
 100,082 bases      Orientation:
 plus strand

Proteins
for CXCL13 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CXL13_HUMAN, O43927 (See protein sequence)
Recommended Name: C-X-C motif chemokine 13 precursor  
Size: 109 amino acids; 12664 Da
Subcellular location: Secreted

Explore the universe of human proteins at neXtProt for CXCL13: NX_O43927

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43927

    • CXCL13 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006410.1  
    ENSEMBL proteins: 
     ENSP00000286758  
    Reactome Protein details: O43927
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CXCL13 (CXCL13/BLC/BCA-1)
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: CXCL13
    OriGene Custom Protein Services for CXCL13 
    GenScript Purified and Recombinant Proteins for CXCL13
    Novus Biologicals CXCL13 Proteins
    Novus Biologicals CXCL13 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CXCL13
    Browse Proteins at Uscn

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005625soluble fraction ----


    CXCL13 for ontologies           About GeneDecksing



    CXCL13 Antibody Products: 
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    ThermoFisher Antibodies for CXCL13

    Assay Products for CXCL13: 
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    GenScript Custom Assay Services for CXCL13
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for CXCL13 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CXCL13 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001811 Chemokine_IL8-like_dom
     IPR001089 Chemokine_CXC
     IPR018048 Chemokine_CXC_CS

    Graphical View of Domain Structure for InterPro Entry O43927

    ProtoNet protein and cluster: O43927

    1 Blocks protein family: IPB002473 Interleukin-8 signature

    UniProtKB/Swiss-Prot: CXL13_HUMAN, O43927
    Similarity: Belongs to the intercrine alpha (chemokine CxC) family


    Function
    for CXCL13 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CXL13_HUMAN, O43927
    Function: Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium
    release in B-lymphocytes. Binds to BLR1/CXCR5

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCL13
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL13:
    hsa-miR-576-3p hsa-miR-186 hsa-miR-548n
    SwitchGear 3'UTR luciferase reporter plasmid: CXCL13 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXCL13 (see all 7)
    OriGene shRNA RFP: CXCL13
    OriGene siRNA: CXCL13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCL13

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CXCL13

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL13 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL13 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CXCL13 (NM_006419)
    Sino Biological Human cDNA Clone for CXCL13
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL13 

    Cell Line
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    Search LifeMap BioReagents cell lines for CXCL13

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL13

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008009chemokine activity IDA11554781
    GO:0008201heparin binding IDA11708770
    GO:0017134fibroblast growth factor binding IDA11708770
    GO:0031724CXCR5 chemokine receptor binding IDA9463416
    GO:0031735CCR10 chemokine receptor binding IDA10706668


    CXCL13 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Cxcl13tm1Mmi for CXCL13
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cxcl13):
     cellular  hematopoietic system  immune system 

    CXCL13 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CXCL13 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    8/9 pathways (see all 9)
    		PEDF Induced Signaling1.00
    		RAR-Gamma-RXR-Alpha Degradation0.54
    		MIF Mediated Glucocorticoid Regulation0.73
    		STAT3 Pathway0.47
    		MIF Regulation of Innate Immune Cells0.71
    		Endothelin-1 Signaling Pathway0.44
    		IL-6 Pathway0.61
    		Cytokine-cytokine receptor interaction0.26
    2Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		Peptide ligand-binding receptors0.61
    		GPCR ligand binding0.75
    		G alpha (i) signalling events0.44
    3Apoptosis and survival_Lymphotoxin-beta receptor signaling
    		Apoptosis and survival Lymphotoxin-beta receptor signaling1.00
    		LT-BetaR Pathway0.46
    		Apoptosis and survival_Lymphotoxin-beta receptor signaling1.00
    4Rho Family GTPases
    		Rho Family GTPases1.00
    		Molecular Mechanisms of Cancer0.51
    		ERK Signaling0.61
    5Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CXCL13
        Apoptosis and survival Lymphotoxin-beta receptor signaling

    5/18 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CXCL13 (see all 18)
        LT-BetaR Pathway
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes

    1 GeneGo (Thomson Reuters) Pathway for CXCL13
        Apoptosis and survival Lymphotoxin-beta receptor signaling

    1 BioSystems Pathway for CXCL13 
        CXCR3-mediated signaling events

    5/8        Reactome Pathways for CXCL13 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    2         Kegg Pathways  (Kegg details for CXCL13):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway


    CXCL13 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CXCL13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/156 Interacting proteins for CXCL13 (O439272, 3 ENSP000002867584) via UniProtKB, MINT, STRING, and/or I2D (see all 156)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYNP062412, 3, ENSP000003576564MINT-8110959 I2D: score=1 STRING: ENSP00000357656
    EEF1GP266412, 3MINT-63167 I2D: score=5 
    CCL19Q997313, ENSP000003088154I2D: score=2 STRING: ENSP00000308815
    CCR10P460923, ENSP000003325044I2D: score=2 STRING: ENSP00000332504
    CXCR5P323023, ENSP000002921744I2D: score=2 STRING: ENSP00000292174
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002467germinal center formation NAS16543475
    GO:0002518lymphocyte chemotaxis across high endothelial venule ISS--
    GO:0002544chronic inflammatory response NAS15284119
    GO:0002920regulation of humoral immune response NAS16531331
    GO:0006955immune response IC11554781


    CXCL13 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CXCL13 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CXCL13 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CXCL13

    1 HMDB Compound for CXCL13    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    3 Novoseek chemical compound relationships for CXCL13 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    teck 83.4 4 18501472 (1), 20109310 (1), 10967023 (1)
    peg-10 72.5 5 16225771 (2), 17082584 (2)
    calcium 0 4 11554781 (2), 9463416 (1), 14600836 (1)

    Search CenterWatch for drugs/clinical trials and news about CXCL13 / CXL13 

    Transcripts
    for CXCL13 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CXCL13 gene: 
    NM_006419.2  

    Unigene Cluster for CXCL13:

    Chemokine (C-X-C motif) ligand 13
    Hs.100431  [show with all ESTs]
    Unigene Representative Sequence: NM_006419
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000286758(uc003hkr.3) ENST00000506590

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCL13
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL13:
    hsa-miR-576-3p hsa-miR-186 hsa-miR-548n
    SwitchGear 3'UTR luciferase reporter plasmid: CXCL13 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXCL13 (see all 7)
    OriGene shRNA RFP: CXCL13
    OriGene siRNA: CXCL13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCL13
    Clone
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    GenScript: all cDNA clones in your preferred vector: CXCL13 (NM_006419)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL13

    Additional cDNA sequence: 

    AF029894.1 AF044197.1 AJ002211.1 BC012589.1 CR407624.1 

    5 DOTS entries:

    DT.452512  DT.92422575  DT.75120990  DT.91832529  DT.121242389 

    24/99 AceView cDNA sequences (see all 99):

    CB046963 BF057200 BC012589 CA418514 W80984 BM919473 BI521089 AI620182 
    BP338594 AI767090 AI819524 AW445025 AW440518 BF057804 BE503228 AW515662 
    AW768461 AI612763 AI621076 AI650870 CR407624 AI360623 AF029894 BI834605 

    GeneLoc Exon Structure


    Expression
    for CXCL13 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CXCL13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATCCTTTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CXCL13 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeBody Subcutaneous White AdiposeAdipose
    AdiposeThoracic Perivascular AdiposeAdipose
    Head MesenchymeFrontonasal ProcessHead Mesenchyme
    KidneyInterstitial StromaKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    HyStem+BMP4-induced 7SMOO32 cells (HyStem+BMP4 inductio...)Adipose
    HyStem+TGF?3+GDF5-induced 7PEND24 cells (HyStem+TGF?3+GDF5 in...)Bone
    Mature follicles (In-vitro growth and ...)

    See CXCL13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CXCL13

    SOURCE GeneReport for Unigene cluster: Hs.100431

    UniProtKB/Swiss-Prot: CXL13_HUMAN, O43927
    Tissue specificity: Highest levels in liver, followed by spleen, lymph node, appendix and stomach. Low levels in
    salivary gland, mammary gland and fetal spleen

        SABiosciences Expression via Pathway-Focused PCR Arrays including CXCL13 (see all 6): 
              Lung Cancer in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL13

    Orthologs
    for CXCL13 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CXCL13 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cxcl131 , 5 chemokine (C-X-C motif) ligand 131, 5 66.67(n)1
    48.08(a)1    		   5 (47.29 cM)5
    559851  NM_018866.21  NP_061354.11 
     959569395 
    chicken
    (Gallus gallus)    		 Aves --
    		 Uncharacterized protein
    		 34(a)
    		 1 ↔ 1
    		 4(36133252-36134522)


    ENSEMBL Gene Tree for CXCL13 (if available)
    TreeFam Gene Tree for CXCL13 (if available) 

    Paralogs
    for CXCL13 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for CXCL13 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CXCL13
         1 CNV: 63869
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CXCL13
    DNA2.0 Custom Variant and Variant Library Synthesis for CXCL13

    Disorders / Diseases
    for CXCL13 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CXCL13 for disorders           About GeneDecksing

    OMIM gene information: 605149    OMIM disorders: --

    20/60 diseases for CXCL13 (see all 60):    About MalaCards
    burkitt's lymphoma    central nervous system lymphoma    hypersensitivity reaction type ii disease    dendritic cell sarcoma
    follicular dendritic cell sarcoma    neuromyelitis optica    graft versus host disease    malt lymphoma
    non-hodgkin lymphoma    myasthenia gravis    thymic hyperplasia    relapsing fever
    oral squamous cell carcinoma    systemic lupus erythematosus    lymphocytic leukemia    squamous cell carcinoma
    peripheral t-cell lymphoma    sjogren's syndrome    lupus erythematosus    autoimmune thyroiditis

    2 diseases from the University of Copenhagen DISEASES database for CXCL13:
    Lyme disease     Lymphoma

    10/18 Novoseek disease relationships for CXCL13 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    angioimmunoblastic t-cell lymphoma 72.9 8 16680156 (5), 16625095 (1), 18792075 (1), 17361209 (1)
    lymphoid hyperplasia 53.8 5 20223524 (2), 16086967 (1), 16680156 (1)
    sjogrens syndrome 51.7 7 11710719 (2), 12832715 (1), 18354239 (1)
    lymphoma t-cell peripheral 49.4 5 16680156 (4), 17361209 (1)
    b-all 48.4 5 16225771 (3), 17082584 (2)
    pseudolymphoma 45.7 2 12855271 (1), 16086967 (1)
    burkitt lymphoma 42.1 3 16565322 (1), 9486651 (1), 11554781 (1)
    primary central nervous system lymphoma 39.6 2 12393412 (1)
    malt lymphoma 37.2 5 10562310 (3), 18354239 (2)
    autoimmune thyroid disease 32.3 1 14763921 (1)

    Human Genome Epidemiology (HuGE) Navigator: CXCL13 (7 documents)

    Export disorders for CXCL13 gene to outside databases

    Publications
    for CXCL13 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CXCL13 gene, integrated from 9 sources (see all 164):
    (articles sorted by number of sources associating them with CXCL13)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. (PubMed id 9463416)1, 2, 3, 9 Legler D.F.... Moser B. (1998)
    2. A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. (PubMed id 9486651)1, 2, 3, 9 Gunn M.D....Williams L.T. (1998)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Human B cell-attracting chemokine 1 (BCA-1; CXCL13) is an agonist for the human CXCR3 receptor. (PubMed id 11554781)1, 9 Jenh C.H....Zavodny P.J. (2001)
    5. Expression of B-cell-attracting chemokine 1 (CXCL13) by malignant lymphocytes and vascular endothelium in primary central nervous system lymphoma. (PubMed id 12393412)1, 9 Smith J.R....Rosenbaum J.T. (2003)
    6. Identification of CXCL13 as a new marker for follicular dendritic cell sarcoma. (PubMed id 18792075)1, 9 Vermi W....Facchetti F. (2008)
    7. Serum levels of the homeostatic B cell chemokine, CXCL13, are elevated during HIV infection. (PubMed id 16318584)1, 9 Widney D.P....Martinez-Maza O. (2005)
    8. The chemokine CXCL13 (BCA-1) inhibits FGF-2 effects on endothelial cells. (PubMed id 11708770)1, 9 Spinetti G....Napolitano M. (2001)
    9. The nervous system as ectopic germinal center: CXCL13 and IgG in lyme neuroborreliosis. (PubMed id 15929033)1, 9 Narayan K....Pachner A.R. (2005)
    10. Monocyte-like and mature macrophages produce CXCL13 (B cell-attracting chemokine 1) in inflammatory lesions with lymphoid neogenesis. (PubMed id 15284119)1, 9 Carlsen H.S....Brandtzaeg P. (2004)

    External Searches for CXCL13 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    Genome Databases showing CXCL13 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10563 HGNC: 10639 AceView: CXCL13 Ensembl:ENSG00000156234 euGenes: HUgn10563
    ECgene: CXCL13 Kegg: 10563 H-InvDB: CXCL13

    Other Databases showing CXCL13 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CXCL13 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CXCL13 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CXCL13 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CXCL13

    Intellectual Property
    for CXCL13 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CXCL13 gene:
    Search GeneIP for patents involving CXCL13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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