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CXCL13 Gene

protein-coding   GIFtS: 63
GCID: GC04P078343

Chemokine (C-X-C Motif) Ligand 13

(Previous names: small inducible cytokine B subfamily (Cys-X-Cys motif),...)
(Previous symbol: SCYB13)
  See CXCL13-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-X-C Motif) Ligand 131 2     CXC Chemokine BLC2 3
SCYB131 2 3 5     ANGIE2
BCA12 3 5     ANGIE22
BLC2 3 5     BLR1L2
Small Inducible Cytokine B Subfamily (Cys-X-Cys Motif), Member 13 (B-Cell
Chemoattractant)1 2
     B-Cell-Attracting Chemokine 12
B-Cell Chemoattractant1 2     B-Cell-Homing Chemokine (Ligand For Burkitt'S Lymphoma Receptor-1)2
B Cell-Attracting Chemokine 12 3     B-Lymphocyte Chemoattractant2
B Lymphocyte Chemoattractant2 3     C-X-C Motif Chemokine 132
Small-Inducible Cytokine B132 3     Chemokine (C-X-C Motif) Ligand 13 (B-Cell Chemoattractant)2
BCA-12 3     Angie3

External Ids:    HGNC: 106391   Entrez Gene: 105632   Ensembl: ENSG000001562347   OMIM: 6051495   UniProtKB: O439273   

Export aliases for CXCL13 gene to outside databases

Previous GC identifers: GC04P078623 GC04P078825 GC04P078891 GC04P078866 GC04P078790 GC04P074184


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CXCL13 Gene:
B lymphocyte chemoattractant, independently cloned and named Angie, is a CXC chemokine strongly expressed in the
follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B
lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis
of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B
lymphocytes to follicles. (provided by RefSeq, Jul 2008)

GeneCards Summary for CXCL13 Gene:
CXCL13 (chemokine (C-X-C motif) ligand 13) is a protein-coding gene. Diseases associated with CXCL13 include thymic hyperplasia, and follicular dendritic cell sarcoma. GO annotations related to this gene include protein heterodimerization activity and chemokine activity.

UniProtKB/Swiss-Prot: CXL13_HUMAN, O43927
Function: Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce
calcium release in B-lymphocytes. Binds to BLR1/CXCR5

Gene Wiki entry for CXCL13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CXCL13 gene promoter:
         ISGF-3   Nkx2-2   Evi-1   RORalpha1   PPAR-gamma1   POU2F1   POU2F1a   IRF-7A   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXCL13 promoter sequence
   Search Chromatin IP Primers for CXCL13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CXCL13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q21.1   HGNC cytogenetic band: 4q21

CXCL13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCL13 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P078343:  view genomic region     (about GC identifiers)

Start:
78,432,907 bp from pter      End:
78,532,988 bp from pter
Size:
100,082 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CXL13_HUMAN, O43927 (See protein sequence)
Recommended Name: C-X-C motif chemokine 13 precursor  
Size: 109 amino acids; 12664 Da

Explore the universe of human proteins at neXtProt for CXCL13: NX_O43927

Explore proteomics data for CXCL13 at MOPED


See CXCL13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_006410.1  
ENSEMBL proteins: 
 ENSP00000286758  
Reactome Protein details: O43927

CXCL13 Human Recombinant Protein Products:

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R&D Systems Recombinant & Natural Proteins for CXCL13 (CXCL13/BLC/BCA-1)
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for CXCL13
OriGene Custom MassSpec
OriGene Custom Protein Services for CXCL13
GenScript Purified and Recombinant Proteins for CXCL13
Novus Biologicals CXCL13 Proteins
Novus Biologicals CXCL13 Lysates
Sino Biological Recombinant Protein for CXCL13
Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for CXCL13
Browse Proteins at Cloud-Clone Corp.

 
Search eBioscience for Proteins for CXCL13 

 
antibodies-online proteins for CXCL13 (36 products) 

 
Search antibodies-online for peptides for CXCL13

CXCL13 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for CXCL13 (CXCL13/BLC/BCA-1)
OriGene Antibodies for CXCL13
OriGene Custom Antibody Services for CXCL13
Novus Biologicals CXCL13 Antibodies
Abcam antibodies for CXCL13
Browse Antibodies at Cloud-Clone Corp.
ThermoFisher Antibodies for CXCL13
antibodies-online antibodies for CXCL13 (71 products) 

CXCL13 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for CXCL13
R&D Systems ELISAs for CXCL13 (CXCL13/BLC/BCA-1)         (see all)
GenScript Custom Assay Services for CXCL13
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.
Search eBioscience for ELISAs for CXCL13 
antibodies-online kits for CXCL13 (13 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ENDOLIG: Endogenous ligands

3 InterPro protein domains:
 IPR001811 Chemokine_IL8-like_dom
 IPR001089 Chemokine_CXC
 IPR018048 Chemokine_CXC_CS

Graphical View of Domain Structure for InterPro Entry O43927

ProtoNet protein and cluster: O43927

1 Blocks protein domain: IPB002473 Interleukin-8 signature

UniProtKB/Swiss-Prot: CXL13_HUMAN, O43927
Similarity: Belongs to the intercrine alpha (chemokine CxC) family


Find genes that share domains with CXCL13           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CXL13_HUMAN, O43927
Function: Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce
calcium release in B-lymphocytes. Binds to BLR1/CXCR5

     Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008009chemokine activity IDA11554781
GO:0008201heparin binding IDA11708770
GO:0017134fibroblast growth factor binding IDA11708770
GO:0031724CXCR5 chemokine receptor binding IDA9463416
GO:0031735CCR10 chemokine receptor binding IDA10706668
     
Find genes that share ontologies with CXCL13           About GenesLikeMe


Phenotypes:
     3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cxcl13):
 cellular  hematopoietic system  immune system 

Find genes that share phenotypes with CXCL13           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Cxcl13tm1Mmi for CXCL13

   genOway: Develop your customized and physiologically relevant rodent model for CXCL13

miRNA
Products:
    
miRTarBase miRNAs that target CXCL13:
hsa-mir-26b-5p (MIRT028916)

Block miRNA regulation of human, mouse, rat CXCL13 using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate CXCL13:
hsa-miR-576-3p hsa-miR-186 hsa-miR-548n
SwitchGear 3'UTR luciferase reporter plasmidCXCL13 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for CXCL13
Predesigned siRNA for gene silencing in human, mouse, rat CXCL13

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CXCL13

Clone
Products:
     
OriGene clones in human, mouse for CXCL13 (see all 7)
OriGene ORF clones in mouse, rat for CXCL13
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CXCL13 (NM_006419)
Sino Biological Human cDNA Clone for CXCL13
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL13
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL13

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for CXCL13
Browse ESI BIO Cell Lines and PureStem Progenitors for CXCL13 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL13


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CXL13_HUMAN, O43927: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
cytoskeleton1
nucleus1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IEA--

Find genes that share ontologies with CXCL13           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CXCL13 About   (see all 11)  
See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1PEDF Induced Signaling
MIF Regulation of Innate Immune Cells0.94
IL-6 Pathway0.61
MIF Mediated Glucocorticoid Regulation0.94
STAT3 Pathway0.47
PEDF Induced Signaling0.73
Endothelin-1 Signaling Pathway0.46
all-trans-Retinoic Acid Signaling in Brain0.71
Cytokine-cytokine receptor interaction0.43
2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
Chemokine receptors bind chemokines0.81
Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
3LT-BetaR Pathway
Apoptosis and survival Lymphotoxin beta receptor signaling0.46
LT-BetaR Pathway0.46
4Chemokine Signaling
Chemokine signaling pathway0.33
Chemokine Signaling0.33
5Peptide ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)0.71
Peptide ligand-binding receptors0.60
GPCR ligand binding0.71
G alpha (i) signalling events0.44


Find genes that share SuperPaths with CXCL13           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 R&D Systems Pathway for CXCL13
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CXCL13 (see all 18)
    LT-BetaR Pathway
Endothelin-1 Signaling Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
Transendothelial Migration of Leukocytes

1 GeneGo (Thomson Reuters) Pathway for CXCL13
    Apoptosis and survival Lymphotoxin-beta receptor signaling

1 BioSystems Pathway for CXCL13
    CXCR3-mediated signaling events


2 Reactome Pathways for CXCL13
    Chemokine receptors bind chemokines
G alpha (i) signalling events


2 Kegg Pathways  (Kegg details for CXCL13):
    Cytokine-cytokine receptor interaction
Chemokine signaling pathway

    Pathway & Disease-focused RT2 Profiler PCR Arrays including CXCL13 (see all 6): 
          Lung Cancer in human mouse rat
          Angiogenic Growth Factors in human mouse rat
          Inflammatory Cytokines & Receptors in human mouse rat
          Cytokines & Chemokines in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Interactions:

    GeneGlobe Interaction Network for CXCL13

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CXCL13 (O439272, 3 ENSP000002867584) via UniProtKB, MINT, STRING, and/or I2D (see all 161)
InteractantInteraction Details
GeneCardExternal ID(s)
FYNP062412, 3, ENSP000003576564MINT-8110959 I2D: score=1 STRING: ENSP00000357656
EEF1GP266412, 3MINT-63167 I2D: score=5 
CCL19Q997313, ENSP000003088154I2D: score=2 STRING: ENSP00000308815
CCR10P460923, ENSP000003325044I2D: score=2 STRING: ENSP00000332504
CXCR5P323023, ENSP000002921744I2D: score=2 STRING: ENSP00000292174
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Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002467germinal center formation NAS16543475
GO:0002518lymphocyte chemotaxis across high endothelial venule ISS--
GO:0002544chronic inflammatory response NAS15284119
GO:0002920regulation of humoral immune response NAS16531331
GO:0006955immune response IC11554781

Find genes that share ontologies with CXCL13           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CXCL13 (CXL13)

1 HMDB Compound for CXCL13    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--

3 Novoseek inferred chemical compound relationships for CXCL13 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
teck 83.4 4 18501472 (1), 20109310 (1), 10967023 (1)
peg-10 72.5 5 16225771 (2), 17082584 (2)
calcium 0 4 11554781 (2), 9463416 (1), 14600836 (1)



Find genes that share compounds with CXCL13           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CXCL13 gene: 
NM_006419.2  

Unigene Cluster for CXCL13:

Chemokine (C-X-C motif) ligand 13
Hs.100431  [show with all ESTs]
Unigene Representative Sequence: NM_006419
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000286758(uc003hkr.3) ENST00000506590
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat CXCL13 using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate CXCL13:
hsa-miR-576-3p hsa-miR-186 hsa-miR-548n
SwitchGear 3'UTR luciferase reporter plasmidCXCL13 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for CXCL13
Predesigned siRNA for gene silencing in human, mouse, rat CXCL13
Clone
Products:
     
OriGene clones in human, mouse for CXCL13 (see all 7)
OriGene ORF clones in mouse, rat for CXCL13
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CXCL13 (NM_006419)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL13
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL13
Primer
Products:
    
OriGene qPCR primer pairs and template standards for CXCL13
OriGene qSTAR qPCR primer pairs in human, mouse for CXCL13
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CXCL13
  QuantiTect SYBR Green Assays in human, mouse, rat CXCL13
  QuantiFast Probe-based Assays in human, mouse, rat CXCL13

Additional mRNA sequence: 

AF029894.1 AF044197.1 AJ002211.1 BC012589.1 CR407624.1 

5 DOTS entries:

DT.452512  DT.92422575  DT.75120990  DT.91832529  DT.121242389 

Selected AceView cDNA sequences (see all 99):

AI360623 CR407624 AI650870 AW440518 AW445025 AW515662 BE503228 AI819524 
AW768461 BF057804 AI612763 AI621076 BF057200 BC012589 BP338594 AI620182 
W80984 BI521089 BM919473 AI767090 CA418514 CB046963 W81087 AA410383 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CXCL13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TATCCTTTCA
CXCL13 Expression
About this image


CXCL13 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 7) fully expand
 
 Bone (Muscoskeletal System)    fully expand to see all 4 entries
         Bone Marrow
         Chondrocyte-like cells
 
 Adipose (Muscoskeletal System)    fully expand to see all 2 entries
         Visceral White Adipocytes Visceral White Adipose
         HyStem+BMP4-induced 7SMOO32 cells
 
 Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
         Chondrocyte-like cells
 
 Ovary (Reproductive System)
         Mature follicles
 
 Testis (Reproductive System)
         Leydig Cells Testis Interstitium
CXCL13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CXCL13 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.100431

UniProtKB/Swiss-Prot: CXL13_HUMAN, O43927
Tissue specificity: Highest levels in liver, followed by spleen, lymph node, appendix and stomach. Low levels in
salivary gland, mammary gland and fetal spleen

    Pathway & Disease-focused RT2 Profiler PCR Arrays including CXCL13 (see all 6): 
          Lung Cancer in human mouse rat
          Angiogenic Growth Factors in human mouse rat
          Inflammatory Cytokines & Receptors in human mouse rat
          Cytokines & Chemokines in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for CXCL13
OriGene qSTAR qPCR primer pairs in human, mouse for CXCL13
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CXCL13
QuantiTect SYBR Green Assays in human, mouse, rat CXCL13
QuantiFast Probe-based Assays in human, mouse, rat CXCL13
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL13

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for CXCL13 gene from Selected species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cxcl131 , 5 chemokine (C-X-C motif) ligand 131, 5 64.04(n)1
44.94(a)1
  5 (47.29 cM)5
559851  NM_018866.21  NP_061354.11 
 959569395 


ENSEMBL Gene Tree for CXCL13 (if available)
TreeFam Gene Tree for CXCL13 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CXCL13 gene
5 SIMAP similar genes for CXCL13 using alignment to 3 protein entries:     CXL13_HUMAN (see all proteins):
CXCL10    CXCL5    CXCL3    CXCL6    IL8

Find genes that share paralogs with CXCL13           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CXCL13 (see all 2229)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1901391731,2
--78430984(+) ACTCAA/G/TCCTTA 1 -- us2k10--------
rs1173730301,2
F--78431202(+) CCACAC/TAGAAG 1 -- us2k11Minor allele frequency- T:0.03EA 120
rs1827355811,2
--78431236(+) TCCTCA/GAGCCT 1 -- us2k10--------
rs1873056731,2
--78431252(+) TCAGGC/GCTTTG 1 -- us2k10--------
rs1931424141,2
--78431407(+) AGCTGC/TGTTGC 1 -- us2k10--------
rs170027121,2
C,F,H--78431444(+) TTTTCG/ATCTGA 1 -- us2k121Minor allele frequency- A:0.12NA NS EA WA CSA 2052
rs1853241841,2
--78431464(+) AGTTGA/CAGAGA 1 -- us2k10--------
rs1888919701,2
--78431472(+) AGAGAC/GAGACA 1 -- us2k10--------
rs1503003651,2
--78431537(+) GAGGGA/GCAGTT 1 -- us2k10--------
rs1383031221,2
--78431618(+) AAAACA/GCATCA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for CXCL13 (78432907 - 78532988 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for CXCL13:    About this table    
Variant IDTypeSubtypePubMed ID
esv2669104CNV Deletion23128226
nsv4395CNV Insertion18451855
esv29506CNV Loss19812545
nsv829975CNV Gain17160897
nsv7363OTHER Inversion18451855

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CXCL13
DNA2.0 Custom Variant and Variant Library Synthesis for CXCL13

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 605149    OMIM disorders: --

4 diseases for CXCL13:    
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thymic hyperplasia    follicular dendritic cell sarcoma    dendritic cell sarcoma    malt lymphoma

2 diseases from the University of Copenhagen DISEASES database for CXCL13:
Lyme disease     Lymphoma

Find genes that share disorders with CXCL13           About GenesLikeMe

Selected Novoseek inferred disease relationships for CXCL13 gene (see all 18)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
angioimmunoblastic t-cell lymphoma 72.9 8 16680156 (5), 16625095 (1), 18792075 (1), 17361209 (1)
lymphoid hyperplasia 53.8 5 20223524 (2), 16086967 (1), 16680156 (1)
sjogrens syndrome 51.7 7 11710719 (2), 12832715 (1), 18354239 (1)
lymphoma t-cell peripheral 49.4 5 16680156 (4), 17361209 (1)
b-all 48.4 5 16225771 (3), 17082584 (2)
pseudolymphoma 45.7 2 12855271 (1), 16086967 (1)
burkitt lymphoma 42.1 3 16565322 (1), 9486651 (1), 11554781 (1)
primary central nervous system lymphoma 39.6 2 12393412 (1)
malt lymphoma 37.2 5 10562310 (3), 18354239 (2)
autoimmune thyroid disease 32.3 1 14763921 (1)

Genetic Association Database (GAD): CXCL13
Human Genome Epidemiology (HuGE) Navigator: CXCL13 (7 documents)

Export disorders for CXCL13 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CXCL13 gene, integrated from 10 sources (see all 178):
(articles sorted by number of sources associating them with CXCL13)
    Utopia: connect your pdf to the dynamic
world of online information

  1. B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. (PubMed id 9463416)1, 2, 3, 9 Legler D.F.... Moser B. (J. Exp. Med. 1998)
  2. A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. (PubMed id 9486651)1, 2, 3, 9 Gunn M.D....Williams L.T. (Nature 1998)
  3. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
  4. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
  5. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
  6. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  8. Human B cell-attracting chemokine 1 (BCA-1; CXCL13) is an agonist for the human CXCR3 receptor. (PubMed id 11554781)1, 9 Jenh C.H....Zavodny P.J. (Cytokine 2001)
  9. Expression of B-cell-attracting chemokine 1 (CXCL13) by malignant lymphocytes and vascular endothelium in primary central nervous system lymphoma. (PubMed id 12393412)1, 9 Smith J.R....Rosenbaum J.T. (Blood 2003)
  10. Identification of CXCL13 as a new marker for follicular dendritic cell sarcoma. (PubMed id 18792075)1, 9 Vermi W....Facchetti F. (J. Pathol. 2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10563 HGNC: 10639 AceView: CXCL13 Ensembl:ENSG00000156234 euGenes: HUgn10563
ECgene: CXCL13 Kegg: 10563 H-InvDB: CXCL13

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CXCL13 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CXCL13 Genetics and Cytogenetics in Oncology and Haematology
Wikipedia http://en.wikipedia.org/wiki/CXCL13

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CXCL13 gene:
Search GeneIP for patents involving CXCL13

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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