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Aliases for CXCL13 Gene

Aliases for CXCL13 Gene

  • C-X-C Motif Chemokine Ligand 13 2 3 5
  • Small Inducible Cytokine B Subfamily (Cys-X-Cys Motif), Member 13 (B-Cell Chemoattractant) 2 3
  • B Cell-Attracting Chemokine 1 3 4
  • B Lymphocyte Chemoattractant 3 4
  • Small-Inducible Cytokine B13 3 4
  • B-Cell Chemoattractant 2 3
  • CXC Chemokine BLC 3 4
  • SCYB13 3 4
  • ANGIE 3 4
  • BCA-1 3 4
  • BCA1 3 4
  • BLC 3 4
  • B-Cell-Homing Chemokine (Ligand For Burkitts Lymphoma Receptor-1) 3
  • Chemokine (C-X-C Motif) Ligand 13 (B-Cell Chemoattractant) 3
  • Chemokine (C-X-C Motif) Ligand 13 2
  • B-Cell-Attracting Chemokine 1 3
  • B-Lymphocyte Chemoattractant 3
  • C-X-C Motif Chemokine 13 3
  • ANGIE2 3
  • BLR1L 3

External Ids for CXCL13 Gene

Previous HGNC Symbols for CXCL13 Gene

  • SCYB13

Previous GeneCards Identifiers for CXCL13 Gene

  • GC04P078343
  • GC04P078623
  • GC04P078825
  • GC04P078891
  • GC04P078866
  • GC04P078790
  • GC04P074184

Summaries for CXCL13 Gene

Entrez Gene Summary for CXCL13 Gene

  • B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. [provided by RefSeq, Oct 2014]

GeneCards Summary for CXCL13 Gene

CXCL13 (C-X-C Motif Chemokine Ligand 13) is a Protein Coding gene. Diseases associated with CXCL13 include Angioimmunoblastic T-Cell Lymphoma and Burkitt Lymphoma. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include protein heterodimerization activity and chemokine activity.

UniProtKB/Swiss-Prot for CXCL13 Gene

  • Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5.

Gene Wiki entry for CXCL13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL13 Gene

Genomics for CXCL13 Gene

Regulatory Elements for CXCL13 Gene

Enhancers for CXCL13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F077538 0.7 ENCODE 12.2 +26.6 26579 0.2 KLF1 JUN KLF17 FEZF1 ZEB1 ZNF26 PRDM10 FOSL2 FOS KLF8 CXCL13 GC04P077551
GH04F077539 1 Ensembl ENCODE 12.1 +27.1 27148 0.9 KLF17 FEZF1 ZEB1 RFX5 FOS CEBPB USF2 ZEB2 TBX21 ZNF843 CXCL13 CNOT6L GC04P077551
GH04F078244 0.2 ENCODE 4.4 +733.2 733174 1.3 SMARCA4 CXCL13 GC04M078185 SERBP1P5
GH04F077369 0.7 FANTOM5 2.3 -142.0 -142028 0.0 CXCL13 LOC100421142 GC04M077367
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CXCL13 on UCSC Golden Path with GeneCards custom track

Genomic Location for CXCL13 Gene

Chromosome:
4
Start:
77,511,753 bp from pter
End:
77,611,834 bp from pter
Size:
100,082 bases
Orientation:
Plus strand

Genomic View for CXCL13 Gene

Genes around CXCL13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCL13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCL13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL13 Gene

Proteins for CXCL13 Gene

  • Protein details for CXCL13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43927-CXL13_HUMAN
    Recommended name:
    C-X-C motif chemokine 13
    Protein Accession:
    O43927

    Protein attributes for CXCL13 Gene

    Size:
    109 amino acids
    Molecular mass:
    12664 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CXCL13 Gene

neXtProt entry for CXCL13 Gene

Post-translational modifications for CXCL13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CXCL13 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CXCL13 (CXCL13/BLC/BCA-1)
  • Abcam antibodies for CXCL13
  • Santa Cruz Biotechnology (SCBT) Antibodies for CXCL13

No data available for DME Specific Peptides for CXCL13 Gene

Domains & Families for CXCL13 Gene

Gene Families for CXCL13 Gene

Suggested Antigen Peptide Sequences for CXCL13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43927

UniProtKB/Swiss-Prot:

CXL13_HUMAN :
  • Belongs to the intercrine alpha (chemokine CxC) family.
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL13: view

Function for CXCL13 Gene

Molecular function for CXCL13 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5.

Gene Ontology (GO) - Molecular Function for CXCL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0008009 chemokine activity IEA,IDA 11554781
GO:0008201 heparin binding IDA 11708770
GO:0017134 fibroblast growth factor binding IDA 11708770
GO:0031724 CXCR5 chemokine receptor binding IEA,IDA 9463416
genes like me logo Genes that share ontologies with CXCL13: view
genes like me logo Genes that share phenotypes with CXCL13: view

Animal Models for CXCL13 Gene

MGI Knock Outs for CXCL13:

Animal Model Products

miRNA for CXCL13 Gene

miRTarBase miRNAs that target CXCL13

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CXCL13 Gene

Localization for CXCL13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL13 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CXCL13 Gene COMPARTMENTS Subcellular localization image for CXCL13 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 2
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CXCL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IBA --
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with CXCL13: view

Pathways & Interactions for CXCL13 Gene

genes like me logo Genes that share pathways with CXCL13: view

Gene Ontology (GO) - Biological Process for CXCL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002467 germinal center formation NAS 16543475
GO:0002518 lymphocyte chemotaxis across high endothelial venule ISS --
GO:0002544 chronic inflammatory response NAS 15284119
GO:0002920 regulation of humoral immune response NAS 16531331
GO:0006935 chemotaxis IEA --
genes like me logo Genes that share ontologies with CXCL13: view

No data available for SIGNOR curated interactions for CXCL13 Gene

Drugs & Compounds for CXCL13 Gene

(1) Drugs for CXCL13 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(2) Additional Compounds for CXCL13 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CXCL13: view

Transcripts for CXCL13 Gene

mRNA/cDNA for CXCL13 Gene

Unigene Clusters for CXCL13 Gene

Chemokine (C-X-C motif) ligand 13:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL13 Gene

No ASD Table

Relevant External Links for CXCL13 Gene

GeneLoc Exon Structure for
CXCL13
ECgene alternative splicing isoforms for
CXCL13

Expression for CXCL13 Gene

mRNA expression in normal human tissues for CXCL13 Gene

mRNA differential expression in normal tissues according to GTEx for CXCL13 Gene

This gene is overexpressed in Spleen (x38.1) and Small Intestine - Terminal Ileum (x6.1).

Protein differential expression in normal tissues from HIPED for CXCL13 Gene

This gene is overexpressed in Stomach (29.4), Lung (13.9), Testis (10.9), and Esophagus (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CXCL13 Gene



Protein tissue co-expression partners for CXCL13 Gene

NURSA nuclear receptor signaling pathways regulating expression of CXCL13 Gene:

CXCL13

SOURCE GeneReport for Unigene cluster for CXCL13 Gene:

Hs.100431

mRNA Expression by UniProt/SwissProt for CXCL13 Gene:

O43927-CXL13_HUMAN
Tissue specificity: Highest levels in liver, followed by spleen, lymph node, appendix and stomach. Low levels in salivary gland, mammary gland and fetal spleen.
genes like me logo Genes that share expression patterns with CXCL13: view

Primer Products

Orthologs for CXCL13 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CXCL13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXCL13 34 35
  • 99.69 (n)
dog
(Canis familiaris)
Mammalia CXCL13 34 35
  • 75.62 (n)
cow
(Bos Taurus)
Mammalia CXCL13 34 35
  • 72.59 (n)
rat
(Rattus norvegicus)
Mammalia Cxcl13 34
  • 67.04 (n)
mouse
(Mus musculus)
Mammalia Cxcl13 34 16 35
  • 64.04 (n)
Species where no ortholog for CXCL13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL13 Gene

ENSEMBL:
Gene Tree for CXCL13 (if available)
TreeFam:
Gene Tree for CXCL13 (if available)

Paralogs for CXCL13 Gene

(5) SIMAP similar genes for CXCL13 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CXCL13: view

No data available for Paralogs for CXCL13 Gene

Variants for CXCL13 Gene

Sequence variations from dbSNP and Humsavar for CXCL13 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10009964 -- 77,579,519(+) TGCTA(C/T)TGGAG intron-variant
rs10014494 -- 77,530,710(+) ttgat(A/C)ttttc intron-variant
rs10017991 -- 77,549,664(+) cagca(C/G)aggct intron-variant
rs10022693 -- 77,612,098(+) CTTAA(C/T)ATAGC downstream-variant-500B
rs10518176 -- 77,559,026(-) TATCT(G/T)ACATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CXCL13 Gene

Variant ID Type Subtype PubMed ID
esv2669104 CNV deletion 23128226
esv29506 CNV loss 19812545
esv3601076 CNV loss 21293372
esv3601077 CNV loss 21293372
nsv1010104 CNV loss 25217958
nsv1119999 CNV deletion 24896259
nsv1134095 CNV deletion 24896259
nsv4395 CNV insertion 18451855
nsv7363 OTHER inversion 18451855
nsv829975 CNV gain 17160897

Variation tolerance for CXCL13 Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CXCL13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXCL13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL13 Gene

Disorders for CXCL13 Gene

MalaCards: The human disease database

(11) MalaCards diseases for CXCL13 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
angioimmunoblastic t-cell lymphoma
  • aitl
burkitt lymphoma
  • burkitt's lymphoma
lymphoma
  • lymphoid cancer
sjogren's syndrome
  • sicca syndrome
asymptomatic neurosyphilis
  • neurosyphilis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CXCL13

Genetic Association Database (GAD)
CXCL13
Human Genome Epidemiology (HuGE) Navigator
CXCL13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CXCL13
genes like me logo Genes that share disorders with CXCL13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL13 Gene

Publications for CXCL13 Gene

  1. B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. (PMID: 9463416) Legler D.F. … Moser B. (J. Exp. Med. 1998) 2 3 4 22 64
  2. A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. (PMID: 9486651) Gunn M.D. … Williams L.T. (Nature 1998) 2 3 4 22 64
  3. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L. … Crovella S. (Vaccine 2010) 3 46 64
  4. Evaluation of the presence of B-cell attractant chemokines in chronic rhinosinusitis. (PMID: 20109310) Patadia M. … Schleimer R. (Am J Rhinol Allergy 2010) 3 22 64
  5. Ectopic and high CXCL13 chemokine expression in myasthenia gravis with thymic lymphoid hyperplasia. (PMID: 20223524) Shiao Y.M. … Chiu H.C. (J. Neuroimmunol. 2010) 3 22 64

Products for CXCL13 Gene

Sources for CXCL13 Gene

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