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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CXCL13 Gene

protein-coding   GIFtS: 64
GCID: GC04P078343

Chemokine (C-X-C Motif) Ligand 13

(Previous names: small inducible cytokine B subfamily (Cys-X-Cys motif),...)
(Previous symbol: SCYB13)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chemokine (C-X-C Motif) Ligand 131 2     CXC Chemokine BLC2 3
SCYB131 2 3 5     ANGIE2
BCA12 3 5     ANGIE22
BLC2 3 5     BLR1L2
Small Inducible Cytokine B Subfamily (Cys-X-Cys Motif), Member 13 (B-Cell
Chemoattractant)1 2
     B-Cell-Attracting Chemokine 12
B-Cell Chemoattractant1 2     B-Cell-Homing Chemokine (Ligand For Burkitt'S Lymphoma Receptor-1)2
B Cell-Attracting Chemokine 12 3     B-Lymphocyte Chemoattractant2
B Lymphocyte Chemoattractant2 3     C-X-C Motif Chemokine 132
Small-Inducible Cytokine B132 3     Chemokine (C-X-C Motif) Ligand 13 (B-Cell Chemoattractant)2
BCA-12 3     Angie3

External Ids:    HGNC: 106391   Entrez Gene: 105632   Ensembl: ENSG000001562347   OMIM: 6051495   UniProtKB: O439273   

Export aliases for CXCL13 gene to outside databases

Previous GC identifers: GC04P078623 GC04P078825 GC04P078891 GC04P078866 GC04P078790 GC04P074184


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CXCL13 Gene:
B lymphocyte chemoattractant, independently cloned and named Angie, is a CXC chemokine strongly expressed in the
follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B
lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis
of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B
lymphocytes to follicles. (provided by RefSeq, Jul 2008)

GeneCards Summary for CXCL13 Gene: 
CXCL13 (chemokine (C-X-C motif) ligand 13) is a protein-coding gene. Diseases associated with CXCL13 include burkitt's lymphoma, and thymic hyperplasia, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and LT-BetaR Pathway. GO annotations related to this gene include protein heterodimerization activity and chemokine activity.

UniProtKB/Swiss-Prot: CXL13_HUMAN, O43927
Function: Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce
calcium release in B-lymphocytes. Binds to BLR1/CXCR5

Gene Wiki entry for CXCL13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CXCL13 gene promoter:
         ISGF-3   Nkx2-2   Evi-1   RORalpha1   PPAR-gamma1   POU2F1   POU2F1a   IRF-7A   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXCL13 promoter sequence
   Search SABiosciences Chromatin IP Primers for CXCL13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCL13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q21.1   HGNC cytogenetic band: 4q21

CXCL13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCL13 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P078343:  view genomic region     (about GC identifiers)

Start:
78,432,907 bp from pter      End:
78,532,988 bp from pter
Size:
100,082 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CXL13_HUMAN, O43927 (See protein sequence)
Recommended Name: C-X-C motif chemokine 13 precursor  
Size: 109 amino acids; 12664 Da
Subcellular location: Secreted

Explore the universe of human proteins at neXtProt for CXCL13: NX_O43927

Explore proteomics data for CXCL13 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43927

  • CXCL13 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CXCL13 Protein Expression
    REFSEQ proteins: NP_006410.1  
    ENSEMBL proteins: 
     ENSP00000286758  
    Reactome Protein details: O43927
    Human Recombinant Protein Products for CXCL13: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CXCL13 (CXCL13/BLC/BCA-1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CXCL13
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CXCL13
    GenScript Purified and Recombinant Proteins for CXCL13
    Novus Biologicals CXCL13 Proteins
    Novus Biologicals CXCL13 Lysates
    Sino Biological Recombinant Protein for CXCL13
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CXCL13
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    CXCL13 for ontologies           About GeneDecksing



    CXCL13 Antibody Products: 
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    Novus Biologicals CXCL13 Antibodies
    Abcam antibodies for CXCL13
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for CXCL13
    LSBio Antibodies in human, mouse, rat for CXCL13 

    Assay Products for CXCL13: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CXCL13
    R&D Systems ELISAs for CXCL13 (CXCL13/BLC/BCA-1)         (see all)
    GenScript Custom Assay Services for CXCL13
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands

    3 InterPro protein domains:
     IPR001811 Chemokine_IL8-like_dom
     IPR001089 Chemokine_CXC
     IPR018048 Chemokine_CXC_CS

    Graphical View of Domain Structure for InterPro Entry O43927

    ProtoNet protein and cluster: O43927

    1 Blocks protein domain: IPB002473 Interleukin-8 signature

    UniProtKB/Swiss-Prot: CXL13_HUMAN, O43927
    Similarity: Belongs to the intercrine alpha (chemokine CxC) family


    CXCL13 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CXL13_HUMAN, O43927
    Function: Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce
    calcium release in B-lymphocytes. Binds to BLR1/CXCR5

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008009chemokine activity IDA11554781
    GO:0008201heparin binding IDA11708770
    GO:0017134fibroblast growth factor binding IDA11708770
    GO:0031724CXCR5 chemokine receptor binding IDA9463416
    GO:0031735CCR10 chemokine receptor binding IDA10706668
         
    CXCL13 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cxcl13):
     cellular  hematopoietic system  immune system 

    CXCL13 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cxcl13tm1Mmi for CXCL13

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CXCL13 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CXCL13

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CXCL13 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CXCL13 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCL13
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL13:
    hsa-miR-576-3p hsa-miR-186 hsa-miR-548n
    SwitchGear 3'UTR luciferase reporter plasmidCXCL13 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CXCL13
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CXCL13

    Clone
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    GenScript: all cDNA clones in your preferred vector: CXCL13 (NM_006419)
    Sino Biological Human cDNA Clone for CXCL13
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL13
    Sirion Biotech Customized lentivirus for stable overexpression of CXCL13 
                         Customized lentivirus expression plasmids for stable overexpression of CXCL13 

    Cell Line
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    Search LifeMap BioReagents cell lines for CXCL13
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL13


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CXCL13 About   (see all 11)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    IL-6 Pathway0.61
    MIF Regulation of Innate Immune Cells0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43
    2Apoptosis and survival Lymphotoxin-beta receptor signaling
    Apoptosis and survival Lymphotoxin-beta receptor signaling0.46
    LT-BetaR Pathway0.46
    3Chemokine Signaling
    Chemokine Signaling0.33
    Chemokine signaling pathway0.33
    4Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.46
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CXCL13
        Apoptosis and survival Lymphotoxin-beta receptor signaling

    5/18 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CXCL13 (see all 18)
        LT-BetaR Pathway
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes

    1 GeneGo (Thomson Reuters) Pathway for CXCL13
        Apoptosis and survival Lymphotoxin-beta receptor signaling

    1 BioSystems Pathway for CXCL13
        CXCR3-mediated signaling events


    5/8        Reactome Pathways for CXCL13 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    2         Kegg Pathways  (Kegg details for CXCL13):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway


    CXCL13 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CXCL13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/156 Interacting proteins for CXCL13 (O439272, 3 ENSP000002867584) via UniProtKB, MINT, STRING, and/or I2D (see all 156)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYNP062412, 3, ENSP000003576564MINT-8110959 I2D: score=1 STRING: ENSP00000357656
    EEF1GP266412, 3MINT-63167 I2D: score=5 
    CCL19Q997313, ENSP000003088154I2D: score=2 STRING: ENSP00000308815
    CCR10P460923, ENSP000003325044I2D: score=2 STRING: ENSP00000332504
    CXCR5P323023, ENSP000002921744I2D: score=2 STRING: ENSP00000292174
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002467germinal center formation NAS16543475
    GO:0002518lymphocyte chemotaxis across high endothelial venule ISS--
    GO:0002544chronic inflammatory response NAS15284119
    GO:0002920regulation of humoral immune response NAS16531331
    GO:0006955immune response IC11554781

    CXCL13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CXCL13 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CXCL13 (CXL13)

    1 HMDB Compound for CXCL13    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 Novoseek inferred chemical compound relationships for CXCL13 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    teck 83.4 4 18501472 (1), 20109310 (1), 10967023 (1)
    peg-10 72.5 5 16225771 (2), 17082584 (2)
    calcium 0 4 11554781 (2), 9463416 (1), 14600836 (1)

    Search CenterWatch for drugs/clinical trials and news about CXCL13 / CXL13

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CXCL13 gene: 
    NM_006419.2  

    Unigene Cluster for CXCL13:

    Chemokine (C-X-C motif) ligand 13
    Hs.100431  [show with all ESTs]
    Unigene Representative Sequence: NM_006419
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000286758(uc003hkr.3) ENST00000506590
    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL13:
    hsa-miR-576-3p hsa-miR-186 hsa-miR-548n
    SwitchGear 3'UTR luciferase reporter plasmidCXCL13 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector: CXCL13 (NM_006419)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL13
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    Primer
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    OriGene qPCR primer pairs and template standards for CXCL13
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXCL13
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL13

    Additional mRNA sequence: 

    AF029894.1 AF044197.1 AJ002211.1 BC012589.1 CR407624.1 

    5 DOTS entries:

    DT.452512  DT.92422575  DT.75120990  DT.91832529  DT.121242389 

    24/99 AceView cDNA sequences (see all 99):

    AI360623 CR407624 AI650870 AW440518 AW445025 AW515662 BE503228 AI819524 
    AW768461 BF057804 AI612763 AI621076 BF057200 BC012589 BP338594 AI620182 
    W80984 BI521089 BM919473 AI767090 CA418514 CB046963 AA410383 BI834605 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CXCL13 expression in normal human tissues (normalized intensities)      CXCL13 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATCCTTTCA
    CXCL13 Expression
    About this image


    CXCL13 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
             epididymis ; glandular cells   
     
     Lymph (Hematopoietic System)    fully expand to see all 2 entries
             Lymphnode   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+TGFbeta3+GDF5-induced 7PEND24 cells
     
     Cartilage (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced 7SMOO32 cells
     
     Oral Cavity (Gastrointestinal Tract)
             Salivary gland   

    See CXCL13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CXCL13

    SOURCE GeneReport for Unigene cluster: Hs.100431

    UniProtKB/Swiss-Prot: CXL13_HUMAN, O43927
    Tissue specificity: Highest levels in liver, followed by spleen, lymph node, appendix and stomach. Low levels in
    salivary gland, mammary gland and fetal spleen

        SABiosciences Expression via Pathway-Focused PCR Arrays including CXCL13 (see all 6): 
              Lung Cancer in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for CXCL13
    OriGene qSTAR qPCR primer pairs in human, mouse for CXCL13
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL13
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CXCL13 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cxcl131 , 5 chemokine (C-X-C motif) ligand 131, 5 66.67(n)1
    48.08(a)1
      5 (47.29 cM)5
    559851  NM_018866.21  NP_061354.11 
     959569395 
    chicken
    (Gallus gallus)
    Aves CXCL136
    chemokine (C-X-C motif) ligand 13
    32(a)
    1 ↔ 1
    4(34432250-34433521)


    ENSEMBL Gene Tree for CXCL13 (if available)
    TreeFam Gene Tree for CXCL13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CXCL13 gene
    5 SIMAP similar genes for CXCL13 using alignment to 3 protein entries:     CXL13_HUMAN (see all proteins):
    CXCL10    CXCL5    CXCL3    CXCL6    IL8

    CXCL13 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2229 SNPs in CXCL13 are shown (see all 2229)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1901391731,2
    --78430984(+) ACTCAA/G/TCCTTA 1 -- us2k10--------
    rs1173730301,2
    F--78431202(+) CCACAC/TAGAAG 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs1827355811,2
    --78431236(+) TCCTCA/GAGCCT 1 -- us2k10--------
    rs1873056731,2
    --78431252(+) TCAGGC/GCTTTG 1 -- us2k10--------
    rs1931424141,2
    --78431407(+) AGCTGC/TGTTGC 1 -- us2k10--------
    rs170027121,2
    C,F,H--78431444(+) TTTTCG/ATCTGA 1 -- us2k121Minor allele frequency- A:0.12NA NS EA WA CSA 2052
    rs1853241841,2
    --78431464(+) AGTTGA/CAGAGA 1 -- us2k10--------
    rs1888919701,2
    --78431472(+) AGAGAC/GAGACA 1 -- us2k10--------
    rs1503003651,2
    --78431537(+) GAGGGA/GCAGTT 1 -- us2k10--------
    rs1383031221,2
    --78431618(+) AAAACA/GCATCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CXCL13 (78432907 - 78532988 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CXCL13:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2669104CNV Deletion23128226
    nsv4395CNV Insertion18451855
    esv29506CNV Loss19812545
    nsv829975CNV Gain17160897
    nsv7363OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605149    OMIM disorders: --

    20/61 diseases for CXCL13 (see all 61):    About MalaCards
    burkitt's lymphoma    thymic hyperplasia    angioimmunoblastic t-cell lymphoma    central nervous system lymphoma
    follicular dendritic cell sarcoma    malt lymphoma    gastric lymphoma    dendritic cell sarcoma
    neuromyelitis optica    relapsing fever    peripheral t-cell lymphoma    endometritis
    cryoglobulinemia    autoimmune thyroiditis    sjogren's syndrome    tick-borne encephalitis
    lyme disease    myasthenia gravis    acute lymphocytic leukemia    hypersensitivity reaction type ii disease

    2 diseases from the University of Copenhagen DISEASES database for CXCL13:
    Lyme disease     Lymphoma

    CXCL13 for disorders           About GeneDecksing

    10/18 Novoseek inferred disease relationships for CXCL13 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    angioimmunoblastic t-cell lymphoma 72.9 8 16680156 (5), 16625095 (1), 18792075 (1), 17361209 (1)
    lymphoid hyperplasia 53.8 5 20223524 (2), 16086967 (1), 16680156 (1)
    sjogrens syndrome 51.7 7 11710719 (2), 12832715 (1), 18354239 (1)
    lymphoma t-cell peripheral 49.4 5 16680156 (4), 17361209 (1)
    b-all 48.4 5 16225771 (3), 17082584 (2)
    pseudolymphoma 45.7 2 12855271 (1), 16086967 (1)
    burkitt lymphoma 42.1 3 16565322 (1), 9486651 (1), 11554781 (1)
    primary central nervous system lymphoma 39.6 2 12393412 (1)
    malt lymphoma 37.2 5 10562310 (3), 18354239 (2)
    autoimmune thyroid disease 32.3 1 14763921 (1)

    Genetic Association Database (GAD): CXCL13
    Human Genome Epidemiology (HuGE) Navigator: CXCL13 (7 documents)

    Export disorders for CXCL13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CXCL13 gene, integrated from 9 sources (see all 173):
    (articles sorted by number of sources associating them with CXCL13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. (PubMed id 9463416)1, 2, 3, 9 Legler D.F.... Moser B. (1998)
    2. A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. (PubMed id 9486651)1, 2, 3, 9 Gunn M.D....Williams L.T. (1998)
    3. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)
    4. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
    5. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)
    6. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Human B cell-attracting chemokine 1 (BCA-1; CXCL13) is an agonist for the human CXCR3 receptor. (PubMed id 11554781)1, 9 Jenh C.H....Zavodny P.J. (2001)
    9. Expression of B-cell-attracting chemokine 1 (CXCL13) by malignant lymphocytes and vascular endothelium in primary central nervous system lymphoma. (PubMed id 12393412)1, 9 Smith J.R....Rosenbaum J.T. (2003)
    10. Identification of CXCL13 as a new marker for follicular dendritic cell sarcoma. (PubMed id 18792075)1, 9 Vermi W....Facchetti F. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10563 HGNC: 10639 AceView: CXCL13 Ensembl:ENSG00000156234 euGenes: HUgn10563
    ECgene: CXCL13 Kegg: 10563 H-InvDB: CXCL13

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CXCL13 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CXCL13 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CXCL13

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CXCL13 gene:
    Search GeneIP for patents involving CXCL13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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