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CXCL12 Gene

protein-coding GIFtS: 65

GC10M044185

chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)
(Previous name: stromal cell-derived factor 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: SDF1A, SDF1B, SDF1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
OTTHUMP00000019491 ^²
PBSF ^¹, ², ³
SCYB12 ^¹, ²
SDF-1 ^³
SDF-1a ^¹, ²
SDF-1b ^¹, ²
SDF1 ^², ³, ⁵
SDF1A ^², ³
SDF1B ^², ³
TLSF-a ^¹, ²
TLSF-b ^¹, ²
TPAR1 ^¹, ²
hIRH ^³

Descriptions
C-X-C motif chemokine 12 ^³
Pre-B cell growth-stimulating factor ^³
chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) ^²
stromal cell-derived factor 1 ^¹
stromal cell-derived factor 1 delta ^²
stromal cell-derived factor 1 gamma ^²
stromal cell-derived factor 1a ^²

External Ids
HGNC: 10672¹
Entrez Gene: 6387²
UniProtKB: P48061³
Ensembl: ENSG00000107562⁷

Search outside databases for aliases for CXCL12 gene

Previous GC identifers: GC10M044154 GC10M044334 GC10M044640 GC10M044149

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CXCL12:

For background information on chemokines, see CXCL1 (MIM 155730). Stromal cell-derived factors

1-alpha and 1-beta are small cytokines that belong to the intercrine family, members of which

activate leukocytes and are often induced by proinflammatory stimuli such as lipopolysaccharide,

TNF (see MIM 191160), or IL1 (see MIM 147760). The intercrines are characterized by the presence

of 4 conserved cysteines which form 2 disulfide bonds. They can be classified into 2 subfamilies.

In the CC subfamily, which includes beta chemokine, the cysteine residues are adjacent to each

other. In the CXC subfamily, which includes alpha chemokine, they are separated by an intervening

amino acid. The SDF1 proteins belong to the latter group.[supplied by OMIM]

UniProtKB/Swiss-Prot: SDF1_HUMAN, P48061

Function: Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. SDF-1-beta(3-72)

and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans

seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites

Gene Wiki entry for CXCL12 (Stromal_cell-derived_factor-1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CXCL12 gene

Entrez Gene cytogenetic band: 10q11.1 Ensembl cytogenetic band: 10q11.21 HGNC cytogenetic band: 10q11.1

CXCL12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M044185: (about GC identifiers)

Start:	44,185,611 bp from pter
End:	44,200,548 bp from pter
Size:	14,938 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000010.9 NT_033985.6

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: SDF1_HUMAN, P48061 (See protein sequence)

Recommended Name: Stromal cell-derived factor 1 precursor

Size: 93 amino acids; 10666 Da

Subcellular location: Secreted

Sequence caution: Sequence=CAC10202.1; Type=Erroneous gene model prediction;

PDB structures from and Proteopedia :

1A15 (3D)

1QG7 (3D)

1SDF (3D)

1VMC (3D)

2J7Z (3D)

2K01 (3D)

2K03 (3D)

2K04 (3D)

2K05 (3D)

2NWG (3D)

2SDF (3D)

Secondary accessions: B2R4G0 Q9H554

Alternative splicing: 2 isoforms: P48061-1 P48061-2

Post-translational modifications:

Processed forms SDF-1-beta(3-72) and SDF-1-alpha(3-67) are produced after secretion by proteolytic

cleavage of isoforms Beta and Alpha, respectively. The N-terminal processing is probably achieved

by DPP4. Isoform Alpha is first cleaved at the C-terminus to yield a SDF-1-alpha(1-67)

intermediate before being processsed at the N-terminus. The C-terminal processing of isoform Alpha

is reduced by binding to heparin and, probably, cell surface proteoglycans¹

REFSEQ proteins (3 alternative transcripts):

NP_000600.1 NP_001029058.1 NP_954637.1

ENSEMBL proteins:

ENSP00000379139 ENSP00000339913 ENSP00000363551 ENSP00000363548 ENSP00000379140 ENSP00000379141

Human Recombinant Proteins

	Invitrogen human recombinant proteins for CXCL12
	Millipore Purified and/or Recombinant CXCL12 Protein
	Sigma-Aldrich Proteins for CXCL12
	R&D Systems Recombinant & Natural Proteins for CXCL12 (CXCL12/SDF-1, CXCL12/SDF-1 alpha, CXCL12/SDF-1 beta)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (SDF1, SDF1 alpha, SDF1 beta)
	Human Recombinant Proteins from Abnova (CXCL12)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	IEA	--

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Antibodies for CXCL12:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CXCL12
	Sigma-Aldrich Antibodies for CXCL12
	R&D Systems Antibodies for CXCL12 (CXCL12/SDF-1, CXCL12/SDF-1 beta)
	Cell Signaling Technology (CST) Antibodies for CXCL12 (SDF-1)
	Antibodies from Abcam (SDF1, SDF1 alpha, SDF1 beta), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for CXCL12

Assays for CXCL12:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems Flow Cytometry Kits for CXCL12 (CXCL12/SDF-1, CXCL12/SDF-1 alpha) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P48061

ProtoNet protein and cluster: P48061

UniProtKB/Swiss-Prot: SDF1_HUMAN, P48061

Similarity: Belongs to the intercrine alpha (chemokine CxC) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CXCL12)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CXCL12)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_000609

Applied Biosystems Silencer® siRNAs for CXCL12

Sigma-Aldrich siRNA for CXCL12

Sigma-Aldrich shRNA Panels and shRNA for CXCL12

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CXCL12
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000609
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000609
untagged cDNA clones in CMV expression vector (see all 3): NM_000609

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001033886

UniProtKB/Swiss-Prot: SDF1_HUMAN, P48061

Function: Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. SDF-1-beta(3-72)

and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans

seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites

7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cxcl12):

	hematopoietic system	immune system	lethality-prenatal/perinatal	nervous system
no phenotypic analysis	reproductive system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004871	signal transducer activity	TAS	10491003 10802710
GO:0008009	chemokine activity	TAS	10772939
GO:0008083	growth factor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5 Sigma-Aldrich "Your Favorite Gene" Pathways for CXCL12 (Your Favorite Gene powered by Ingenuity)

Axonal Guidance Signaling
Ephrin Receptor Signaling
Chemokine Signaling
Leukocyte Extravasation Signaling
CXCR4 Signaling

GeneDecks CXCL12 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CXCL12

5/169 Interacting proteins for CXCL12 (ENSP00000363548³ P48061²) via UniProtKB, MINT, and/or STRING (see all 169 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DPP4	P27487²	STRING (score=.962) MINT-6491448 MINT-6491442
DPP8	Q6V1X1²	STRING (score=.771) MINT-6491388 MINT-6491407
CXCR4	ENSP00000241393³	STRING (score=.999)
CXCR7	ENSP00000272928³	STRING (score=.998)
CCR5	ENSP00000292303³	STRING (score=.992)

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5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006874	cellular calcium ion homeostasis	TAS	10772939
GO:0006935	chemotaxis	TAS	10620615
GO:0006955	immune response	TAS	10802710
GO:0007155	cell adhesion	TAS	10198043
GO:0007165	signal transduction	TAS	10491003

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CXCL12
10/50 Novoseek chemical compound relationships for CXCL12 gene (see all 50 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
sdf 1	94.98	234	10413364 (10), 15808852 (9), 18698020 (9), 8751377 (8) (see all 72)
rantes	85.09	162	16011532 (11), 16343773 (4), 11064099 (4), 14717979 (3) (see all 96)
plerixafor	78.24	3	18940680 (1), 18691106 (1), 18847313 (1)
teck	69.92	7	9886241 (1), 10449163 (1), 18501472 (1), 10967023 (1) (see all 5)
ccl3	67.03	14	15542651 (2), 16969502 (2), 12534281 (1), 18097222 (1) (see all 11)
larc	57.68	4	11180126 (1), 10449163 (1), 10934220 (1), 10967023 (1)
pd 98,059	53.41	11	16884765 (2), 15475370 (1), 11207257 (1), 11489936 (1) (see all 8)
tarc	50.85	9	11159520 (4), 12851650 (1), 14717979 (1), 10372118 (1) (see all 5)
matrigel	50.69	21	15059909 (2), 15582259 (2), 11063876 (2), 16278822 (2) (see all 14)
calcium	44.88	118	17384283 (4), 17949241 (3), 14600836 (3), 9353342 (2) (see all 87)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CXCL12)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CXCL12)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_000609

Sigma-Aldrich siRNA for CXCL12

Sigma-Aldrich shRNA Panels and shRNA for CXCL12

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000609 NM_001033886 NM_199168

REFSEQ mRNAs for CXCL12 gene (3 alternative transcripts):

NM_000609.4 NM_001033886.1 NM_199168.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000609 NM_001033886 NM_199168

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000609
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000609
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_000609

Additional cDNA sequence:

AJ227905.1 AK090482.1 AK124641.1 AK292628.1 AK311814.1 AL713778.1 AY644456.1 AY874118.1

BC031072.1 BC039893.1 CR450283.1 CR615181.1 DQ345517.1 DQ345518.1 DQ345519.1 DQ345520.1

L36033.1 L36034.1

16 DOTS entries:

DT.75167133 DT.95274185 DT.447215 DT.121284954 DT.121284964 DT.65284715 DT.100788017 DT.91803447

DT.92421328 DT.100788016 DT.100788018 DT.100810713 DT.91749901 DT.95274178 DT.95306903 DT.87016801

24/323 AceView cDNA sequences (see all 323 ):

NM_000609 BU146385 N70223 BM666552 AA055760 BX113123 BQ722219 BU617163

BI760697 CA426265 AI857805 CA426192 AI277200 CR615181 AA978287 T92785

AU134928 BM704588 AA321546 CA413305 AA348089 CD673056 CA426157 AU119967

highest scoring ESTs for CXCL12:

L36033 AI015208 AI655759 AL538307 AW583054 BC039893 BM545450 BQ716869 BQ878801 BQ878939

Unigene Cluster for CXCL12:

Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)

Hs.522891 [show with all ESTs]

Unigene Representative Sequence: AK090482

GeneLoc Exon Structure

6 Ensembl transcripts including schematic representations:

ENST00000395793 ENST00000343575 ENST00000374429 ENST00000374426 ENST00000395794 ENST00000395795

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CXCL12 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CXCL12

¹ / ² / ³

6 probe-sets matching CXCL12 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33834_at²^{, 3}	U95-A	1	1.00	1.00	0.95	1.06	L36033	1.00	0.90	0.95	1
32666_at²^{, 3}	U95-A	1	1.00	1.00	0.95	0.94	U19495	0.80	1.00	0.91	1
209687_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U19495	0.80	1.00	0.91	1
203666_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000609	0.60	1.00	0.82	1
209687_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203666_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CXCL12 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.522891

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CXCL12 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
rat (Rattus norvegicus)	Cxcl12¹	--	chemokine (C-X-C motif) ligand 12 (stromal cell-derived more	91.6(n) 93.28(a)	24772 NM_001033883.1 NP_001029055.1
mouse (Mus musculus)	Cxcl12^{1, 5}	6 (53.00 cM)⁵	chemokine (C-X-C motif) ligand 12^{1, 5}	92.72(n)¹ 94.96(a)¹	20315¹ NM_001012477.1¹ NP_001012495.1¹ AA387196⁵ AI174028⁵ (see all 25)
chicken (Gallus gallus)	CXCL12¹	--	chemokine (C-X-C motif) ligand 12 (stromal cell-derived more	75.28(n) 73.03(a)	395180 NM_204510.1 NP_989841.1
African clawed frog (Xenopus laevis)	MGC68770²	--	hypothetical protein MGC68770	72.98(n)	AJ278857.1

About this table Species with no ortholog for CXCL12

ENSEMBL Gene Tree for CXCL12

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/198 NCBI SNPs in CXCL12 are shown (see all 198 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 161)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1804429^1,2	A,C,F,H,O	44185847(-)	`GTGAAT/GGATTC`	1	--	ut3¹		14	NA NS EU EA WA	1122
	rs1029153^1,2	A,C,F,H,O	44187152(-)	`AGTGAT/CGTAAT`	1	--	ut3¹		13	MN EU EA WA NA NS	1326
	rs2522^1,2	A,C,F,H	44187310(+)	`AACCCA/GCAAGT`	1	--	ut3¹		15	EU NA NS EA WA	1520
	rs2839696^1,2	A,C,F,H	44186634(-)	`ACTAAC/TAATCA`	1	--	ut3¹		11	EU EA WA NA NS	1092
	rs266092^1,2	C,F,H,O	44186281(+)	`GTATCT/ACAGTG`	1	--	ut3¹		15	MN EU EA WA NA NS	1304
	rs3740085^1,2	A,C,F,H	44187775(+)	`TGGACC/GCACCA`	1	--	ut3¹ ese³		27	EA NA NS MN EU WA	4882
	rs10900031^1,2	A,C,F,H	44187636(+)	`GTTGTG/AAATGC`	1	--	ut3¹ ese³		5	EU EA WA NA	438
	rs1801157^1,2	A,C,F,H	44188263(-)	`GAGCCG/AGGTCT`	1	--	ut3¹		13	EU MN CSAM EA NS WA NA	1352
	rs266093^1,2	A,C,F,H	44186214(+)	`CGGAAG/CCTTTT`	1	--	ut3¹ trp³		26	MN EU NA NS EA WA	2782
--	rs1804430^1,2	C,F,H,O	44185745(-)	`TACGCA/GGCGTG`	1	--	ut3¹ ese³		10	NA NS EU EA WA	702

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HapMap Linkage Disequilibrium images for CXCL12 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600835 disorders: 609423

10/94 Novoseek disease relationships for CXCL12 gene (see all 94 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
whim syndrome	79.60	2	15781337 (1), 18556651 (1)
immunodeficiency	66.22	48	12232832 (2), 9108384 (1), 10413364 (1), 16306611 (1) (see all 43)
neovascularization	64.77	32	19215683 (3), 12628955 (2), 12680875 (1), 16413490 (1) (see all 19)
metastasis	59.11	206	18558091 (5), 18176915 (5), 18223219 (4), 18027722 (4) (see all 91)
hiv infections	49.34	33	12215924 (2), 9108384 (1), 10413364 (1), 10479136 (1) (see all 24)
tumors	47.57	237	19350687 (6), 17355795 (5), 16982747 (4), 18558091 (4) (see all 99)
inflammation	42.82	29	11095335 (3), 18383856 (2), 12444153 (1), 15339043 (1) (see all 24)
cancer	42.30	95	14749473 (4), 15854291 (3), 19199057 (2), 15240098 (2) (see all 58)
hypogammaglobulinemia	40.05	1	18556651 (1)
aids dementia complex	37.89	1	12834106 (1)

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Human Gene Mutation Database: CXCL12
Genetic Association Database: CXCL12
Human Genome Epidemiology Navigator: CXCL12 (97 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

ACS: Possible Mechanism for Cancer Metastasis to the Liver Identified

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/1136 PubMed articles for CXCL12 gene (see all 1136 ):

Structure and chromosomal localization of the human stromal cell- derived factor 1 (SDF1) gene. (PubMed id 7490086)^{1, 2, 3, 4} Shirozu M....Honjo T. (1995)
Role of CCR5, CCR2 and SDF-1 gene polymorphisms in a population of HIV-1 infected individuals. (PubMed id 11693435)^{1, 3, 6} Mazzucchelli R....Balotta C. (2001)
Solution structure and basis for functional activity of stromal cell- derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1. (PubMed id 9384579)^{1, 3, 4} Crump M.P....Clark-Lewis I. (1997)
Stromal cell-derived factor-1 (SDF-1) gene and susceptibility of Iranian patients with lung cancer. (PubMed id 15955592)^{1, 3, 6} Razmkhah M....Ghaderi A. (2005)
Haplotype analysis of the SDF-1 (CXCL12) gene in a longitudinal HIV-1/AIDS cohort study. (PubMed id 16177829)^{1, 3, 6} Modi W.S....Winkler C. (2005)
Risk for HIV-1 infection associated with a common CXCL12 (SDF1) polymorphism and CXCR4 variation in an African population. (PubMed id 16284526)^{1, 3, 6} Petersen D.C....Hayes V.M. (2005)
The stromal derived factor-1 mutated allele (SDF1-3'A) is associated with a lower incidence of atherosclerosis in HIV-infected patients. (PubMed id 16227796)^{1, 3, 6} Coll B....Masana L. (2005)
The impact of polymorphisms in chemokine and chemokine receptors on outcomes in liver transplantation. (PubMed id 12201365)^{1, 3, 6} Schroppel B....Murphy B. (2002)
Associations of CCR5, CCR2, and stromal cell-derived factor 1 genotypes with human immunodeficiency virus disease progression in patients receiving nucleoside therapy. (PubMed id 11709782)^{1, 3, 6} Lathey J.L....Katzenstein D.A. (2001)
Distribution of HIV/AIDS protective SDF1, CCR5 and CCR2 gene variants within Cretan population. (PubMed id 16286055)^{1, 3, 6} Apostolakis S....Spandidos D.A. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 6387	HGNC: 10672	AceView: CXCL12	Ensembl:ENSG00000107562	euGenes: HUgn6387
ECgene: CXCL12	H-InvDB: CXCL12

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CXCL12	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/SDF-1_%28biology%29
SeattleSNPs	http://pga.gs.washington.edu/data/cxcl12/

Licensable Technologies for CXCL12
(Available from WIS Yeda, Salk, Tufts)

About This Section

Licensable Technologies for CXCL12 gene:

Weizmann Institute:

Enrichment of Repopulating Stem Cells For Clinical Protocols

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CXCL12:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CXCL12-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CXCL12		Antibodies for CXCL12
	Explore super-pooled esiRNAs		Proteins for CXCL12
	Lentivirus-delivered shRNAs for CXCL12		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CXCL12)
	Search for Antibodies
	Chimera RNAi (CXCL12)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CXCL12 (SDF-1)

	Recombinant Proteins (SDF1, SDF1 alpha, SDF1 beta)
	Antibodies (SDF1, SDF1 alpha, SDF1 beta)

Search OriGene for CXCL12

Search Tocris compounds for CXCL12

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CXCL12

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CXCL12 Gene at Home site.
Version 2.41.1
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CXCL12 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for CXCL12

Summaries
for CXCL12

Genomic Location
for CXCL12

Proteins
for CXCL12

Protein Domains/
Families
for CXCL12

Gene Function
for CXCL12

Pathways & Interactions
for CXCL12

Drugs & Compounds
for CXCL12

Transcripts
for CXCL12

Expression
for CXCL12

Orthologs
for CXCL12

Paralogs
for CXCL12

SNPs/Variants
for CXCL12

Disorders & Mutations
for CXCL12

Medical News
for CXCL12

Publications
for CXCL12

Search for CXCL12

Genome Databases showing CXCL12

Other Databases showing CXCL12

Specialized Databases showing CXCL12

Licensable Technologies
for CXCL12

Services
for CXCL12

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CXCL12 (Gene Symbol)
OTTHUMP00000019491
PBSF
SCYB12
SDF-1
SDF-1a
SDF-1b
SDF1
SDF1A
SDF1B
TLSF-a
TLSF-b
TPAR1
hIRH
C-X-C motif chemokine 12
Pre-B cell growth-stimulating factor
chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)
stromal cell-derived factor 1
stromal cell-derived factor 1 delta
stromal cell-derived factor 1 gamma
stromal cell-derived factor 1a

CXCL12 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor CXCL12

Summariesfor CXCL12

Genomic Locationfor CXCL12

Proteinsfor CXCL12

Protein Domains/Familiesfor CXCL12

Gene Functionfor CXCL12

Pathways & Interactionsfor CXCL12

Drugs & Compoundsfor CXCL12

Transcriptsfor CXCL12

Expression for CXCL12

Orthologsfor CXCL12

Paralogsfor CXCL12

SNPs/Variantsfor CXCL12

Disorders & Mutationsfor CXCL12

Medical Newsfor CXCL12

Publicationsfor CXCL12

Search for CXCL12

Genome Databases showing CXCL12

Other Databases showing CXCL12

Specialized Databases showing CXCL12

Licensable Technologiesfor CXCL12

Servicesfor CXCL12

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CXCL12

Summaries
for CXCL12

Genomic Location
for CXCL12

Proteins
for CXCL12

Protein Domains/
Families
for CXCL12

Gene Function
for CXCL12

Pathways & Interactions
for CXCL12

Drugs & Compounds
for CXCL12

Transcripts
for CXCL12

Expression
for CXCL12

Orthologs
for CXCL12

Paralogs
for CXCL12

SNPs/Variants
for CXCL12

Disorders & Mutations
for CXCL12

Medical News
for CXCL12

Publications
for CXCL12

Licensable Technologies
for CXCL12

Services
for CXCL12