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CXCL11 Gene

protein-coding   GIFtS: 63
GCID: GC04M076954

Chemokine (C-X-C Motif) Ligand 11

(Previous names: small inducible cytokine subfamily B (Cys-X-Cys), member...)
(Previous symbols: SCYB9B, SCYB11)
  See CXCL11-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-X-C Motif) Ligand 111 2     IP-92 3
SCYB111 2 3 5     IP92 5
SCYB9B1 2 3 5     b-R12
Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 111 2     beta-R12
Interferon Gamma-Inducible Protein 92 3     C-X-C Motif Chemokine 112
Interferon-Inducible T-Cell Alpha Chemoattractant2 3     Small Inducible Cytokine B112
Small-Inducible Cytokine B112 3     Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 9B2
H1742 3     Beta-R13
I-TAC2 3     ITAC3

External Ids:    HGNC: 106381   Entrez Gene: 63732   Ensembl: ENSG000001692487   OMIM: 6048525   UniProtKB: O146253   

Export aliases for CXCL11 gene to outside databases

Previous GC identifers: GC04M076850 GC04M077145 GC04M077347 GC04M077413 GC04M077312 GC04M072707


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CXCL11 Gene:
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that
regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G
protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function
of the immune system, and they have effects on cells of the central nervous system as well as on endothelial
cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This
gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in
activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons
and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma
is a potent inducer of transcription of this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CXCL11 Gene:
CXCL11 (chemokine (C-X-C motif) ligand 11) is a protein-coding gene. Diseases associated with CXCL11 include endotheliitis, and septic arthritis. GO annotations related to this gene include chemokine activity.

UniProtKB/Swiss-Prot: CXL11_HUMAN, O14625
Function: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes.
Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which
involve T-cell recruitment. May play a role in skin immune responses

Gene Wiki entry for CXCL11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CXCL11 gene promoter:
         AML1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXCL11 promoter sequence
   Search Chromatin IP Primers for CXCL11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CXCL11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.2   Ensembl cytogenetic band:  4q21.1   HGNC cytogenetic band: 4q21

CXCL11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCL11 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M076954:  view genomic region     (about GC identifiers)

Start:
76,954,835 bp from pter      End:
76,962,568 bp from pter
Size:
7,734 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CXL11_HUMAN, O14625 (See protein sequence)
Recommended Name: C-X-C motif chemokine 11 precursor  
Size: 94 amino acids; 10365 Da
Mass spectrometry: Mass=8303; Method=MALDI; Range=22-94; Source=PubMed:10233762;
Sequence caution: Sequence=AAB17374.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for CXCL11:
1RJT (3D)    
Secondary accessions: Q53YA3 Q92840

Explore the universe of human proteins at neXtProt for CXCL11: NX_O14625

Explore proteomics data for CXCL11 at MOPED


See CXCL11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_005400.1  
ENSEMBL proteins: 
 ENSP00000306884   ENSP00000425819  
Reactome Protein details: O14625

CXCL11 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for CXCL11 (CXCL11/I-TAC)
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Proteins for CXCL11
OriGene Protein Over-expression Lysate for CXCL11
OriGene Custom MassSpec
OriGene Custom Protein Services for CXCL11
GenScript Purified and Recombinant Proteins for CXCL11
Novus Biologicals CXCL11 Proteins
Novus Biologicals CXCL11 Lysates
Sino Biological Recombinant Protein for CXCL11
Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for CXCL11
Browse Proteins at Cloud-Clone Corp.

 
Search eBioscience for Proteins for CXCL11 

CXCL11 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for CXCL11 (CXCL11/I-TAC)
OriGene Antibodies for CXCL11
OriGene Custom Antibody Services for CXCL11
Novus Biologicals CXCL11 Antibodies
Abcam antibodies for CXCL11
Browse Antibodies at Cloud-Clone Corp.
ThermoFisher Antibody for CXCL11
LSBio Antibodies in human, mouse, rat for CXCL11

CXCL11 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for CXCL11
R&D Systems ELISAs for CXCL11 (CXCL11/I-TAC)         (see all)
GenScript Custom Assay Services for CXCL11
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.
Search eBioscience for ELISAs for CXCL11 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ENDOLIG: Endogenous ligands

4 InterPro protein domains:
 IPR001811 Chemokine_IL8-like_dom
 IPR001089 Chemokine_CXC
 IPR027220 Chemokine_CXCL10/11
 IPR018048 Chemokine_CXC_CS

Graphical View of Domain Structure for InterPro Entry O14625

ProtoNet protein and cluster: O14625

UniProtKB/Swiss-Prot: CXL11_HUMAN, O14625
Similarity: Belongs to the intercrine alpha (chemokine CxC) family


Find genes that share domains with CXCL11           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CXL11_HUMAN, O14625
Function: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes.
Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which
involve T-cell recruitment. May play a role in skin immune responses
Induction: By IFNG/IFN-gamma and IFNB1/IFN-beta. Induction by IFNG/IFN-gamma is enhanced by TNF in monocytes,
dermal fibroblasts and endothelial cells, and by IL1/interleukin-1 in astrocytes

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI18275857
GO:0008009chemokine activity IDA12782716
GO:0008201heparin binding IMP18645041
GO:0048248CXCR3 chemokine receptor binding IDA12782716
     
Find genes that share ontologies with CXCL11           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for CXCL11:
 Increased HPV18 LCR reporter a 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CXCL11
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CXCL11

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CXCL11
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CXCL11

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat CXCL11 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate CXCL11 (see all 18):
hsa-miR-2052 hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-4263 hsa-miR-3129-5p hsa-miR-221 hsa-miR-9 hsa-miR-3915
SwitchGear 3'UTR luciferase reporter plasmidCXCL11 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for CXCL11
Predesigned siRNA for gene silencing in human, mouse, rat CXCL11

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CXCL11

Clone
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OriGene clones in human, mouse for CXCL11 (see all 6)
OriGene ORF clones in mouse, rat for CXCL11
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CXCL11 (NM_005409)
Sino Biological Human cDNA Clone for CXCL11
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL11
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL11

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for CXCL11
Browse ESI BIO Cell Lines and PureStem Progenitors for CXCL11 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL11


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CXL11_HUMAN, O14625: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
nucleus1
plasma membrane1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IEA--

Find genes that share ontologies with CXCL11           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CXCL11 About   (see all 12)  
See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1PEDF Induced Signaling
MIF Regulation of Innate Immune Cells0.94
IL-6 Pathway0.61
MIF Mediated Glucocorticoid Regulation0.94
STAT3 Pathway0.47
PEDF Induced Signaling0.73
Endothelin-1 Signaling Pathway0.46
all-trans-Retinoic Acid Signaling in Brain0.71
Cytokine-cytokine receptor interaction0.43
2Toll-like receptor signaling pathway
Toll-like receptor signaling pathway0.94
Regulation of toll-like receptor signaling pathway0.93
Toll-like receptor signaling pathway0.94
3Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
Chemokine receptors bind chemokines0.81
Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
4Chemokine Signaling
Chemokine signaling pathway0.33
Chemokine Signaling0.33
5Peptide ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)0.71
Peptide ligand-binding receptors0.60
GPCR ligand binding0.71
G alpha (i) signalling events0.44


Find genes that share SuperPaths with CXCL11           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 R&D Systems Pathway for CXCL11
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CXCL11 (see all 17)
    Endothelin-1 Signaling Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
Transendothelial Migration of Leukocytes
MIF Mediated Glucocorticoid Regulation

1 GeneGo (Thomson Reuters) Pathway for CXCL11
    Immune response TLR signaling pathways

3 BioSystems Pathways for CXCL11
    Toll-like receptor signaling pathway
CXCR3-mediated signaling events
Regulation of toll-like receptor signaling pathway


2 Reactome Pathways for CXCL11
    Chemokine receptors bind chemokines
G alpha (i) signalling events


3 Kegg Pathways  (Kegg details for CXCL11):
    Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Toll-like receptor signaling pathway

    Pathway & Disease-focused RT2 Profiler PCR Arrays including CXCL11 (see all 10): 
          Antiviral Response in human mouse rat
          Angiogenic Growth Factors in human mouse rat
          Multiple Sclerosis in human mouse rat
          Wound Healing in human mouse rat
          Inflammatory Response & Autoimmunity in human mouse rat

Interactions:

    GeneGlobe Interaction Network for CXCL11

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CXCL11 (O146251, 2, 3 ENSP000003068844) via UniProtKB, MINT, STRING, and/or I2D (see all 155)
InteractantInteraction Details
GeneCardExternal ID(s)
DPP4P274871, 2, 3, ENSP000003537314EBI-2871971,EBI-2871277 MINT-8091131 I2D: score=2 STRING: ENSP00000353731
CCR3P516773, ENSP000003500034I2D: score=1 STRING: ENSP00000350003
CXCR3P496823, ENSP000003627954I2D: score=3 STRING: ENSP00000362795
ACKR3ENSP000002729284STRING: ENSP00000272928
AGTR2ENSP000003609734STRING: ENSP00000360973
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Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002690positive regulation of leukocyte chemotaxis ----
GO:0006935chemotaxis IDA12782716
GO:0006954inflammatory response IEA--
GO:0006955immune response IEA--
GO:0007165signal transduction TAS10233762

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CXCL11 (CXL11)

1 HMDB Compound for CXCL11    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--

Selected Novoseek inferred chemical compound relationships for CXCL11 gene (see all 11)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
rantes 73 21 11533168 (2), 11110785 (1), 19397398 (1), 15663962 (1) (see all 17)
ccl3 63.6 6 12960247 (2), 15178708 (1), 19406226 (1), 19067439 (1) (see all 5)
tarc 62.2 3 16453150 (2), 11533168 (1)
ccl4 40.3 6 12960247 (2), 19265171 (1), 19067439 (1), 17912012 (1)
lysophosphatidylcholine 20.5 2 11795279 (1), 15621055 (1)
calcium 5.38 15 17363734 (2), 11500837 (2), 15713646 (1), 10825390 (1) (see all 10)
oligonucleotide 0 1 11533168 (1)
progesterone 0 2 15557169 (1), 15126579 (1)
arginine 0 1 16040184 (1)
dexamethasone 0 3 10092813 (1), 10843686 (1)



Find genes that share compounds with CXCL11           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CXCL11 gene: 
NM_005409.4  

Unigene Cluster for CXCL11:

Chemokine (C-X-C motif) ligand 11
Hs.632592  [show with all ESTs]
Unigene Representative Sequence: NM_005409
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000306621(uc003hjm.3) ENST00000503860
miRNA
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Block miRNA regulation of human, mouse, rat CXCL11 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate CXCL11 (see all 18):
hsa-miR-2052 hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-4263 hsa-miR-3129-5p hsa-miR-221 hsa-miR-9 hsa-miR-3915
SwitchGear 3'UTR luciferase reporter plasmidCXCL11 3' UTR sequence
Inhib. RNA
Products:
     
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Predesigned siRNA for gene silencing in human, mouse, rat CXCL11
Clone
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OriGene ORF clones in mouse, rat for CXCL11
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CXCL11 (NM_005409)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL11
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL11
Primer
Products:
    
OriGene qPCR primer pairs and template standards for CXCL11
OriGene qSTAR qPCR primer pairs in human, mouse for CXCL11
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CXCL11
  QuantiTect SYBR Green Assays in human, mouse, rat CXCL11
  QuantiFast Probe-based Assays in human, mouse, rat CXCL11

Additional mRNA sequence: 

AF002985.1 AF030514.1 AF352781.1 BC005292.1 BC012532.1 BC110986.1 BT006787.1 U59286.1 
U66096.1 Y15220.1 

1 DOTS entry:

DT.305593 

Selected AceView cDNA sequences (see all 26):

U66096 BX646683 BT006787 AW802652 D62634 BX112006 NM_005409 Y15220 
AA554678 BQ029949 AA594458 BI820123 AL703031 AA372656 CB986207 BC005292 
BC012532 AF030514 BG687080 AF002985 BF209312 AA361853 BF910176 AF352781 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for CXCL11    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
SP1:                              
SP2:                              


ECgene alternative splicing isoforms for CXCL11

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CXCL11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCTATATACT
CXCL11 Expression
About this image


CXCL11 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Brain (Nervous System)    fully expand to see all 18 entries
         Thalamus
         Substantia Nigra   
CXCL11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CXCL11 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.632592

UniProtKB/Swiss-Prot: CXL11_HUMAN, O14625
Tissue specificity: High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in
thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal
layer keratinocytes in skin disorders

    Pathway & Disease-focused RT2 Profiler PCR Arrays including CXCL11 (see all 10): 
          Antiviral Response in human mouse rat
          Angiogenic Growth Factors in human mouse rat
          Multiple Sclerosis in human mouse rat
          Wound Healing in human mouse rat
          Inflammatory Response & Autoimmunity in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for CXCL11
OriGene qSTAR qPCR primer pairs in human, mouse for CXCL11
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CXCL11
QuantiTect SYBR Green Assays in human, mouse, rat CXCL11
QuantiFast Probe-based Assays in human, mouse, rat CXCL11
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL11

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for CXCL11 gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cxcl115 chemokine (C-X-C motif) ligand 11   --   5 (46.61 cM) 92359544 


ENSEMBL Gene Tree for CXCL11 (if available)
TreeFam Gene Tree for CXCL11 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CXCL11 gene
5 SIMAP similar genes for CXCL11 using alignment to 2 protein entries:     CXL11_HUMAN (see all proteins):
CXCL9    CXCL1    CXCL2    CXCL3    CXCL10

Find genes that share paralogs with CXCL11           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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4 SNPs for CXCL11    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs58594881,2
C,F--76956289(+) CATACAA/-AAGAG 1 -- int13Minor allele frequency- -:0.20NA CSA 10
rs574123921,2
C--76957824(+) TTTTA-/AATTT 
        
AATTT
1 -- us2k10--------
rs105516511,2
C--76959230(+) TTTAA-/ATTGT 
        
GCACT
1 -- us2k11Minor allele frequency- ATTGT:0.00CSA 2
rs48595961,2,4
----see VAR_0487002 mis40--------

HapMap Linkage Disequilibrium report for CXCL11 (76954835 - 76962568 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for CXCL11:    About this table    
Variant IDTypeSubtypePubMed ID
esv27112CNV Gain19812545
nsv7363OTHER Inversion18451855

Human Gene Mutation Database (HGMD): CXCL11
Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 604852    OMIM disorders: --

10 diseases for CXCL11:    
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endotheliitis    septic arthritis    vernal keratoconjunctivitis    autoimmune thyroiditis
mycosis fungoides    relapsing-remitting multiple sclerosis    cerebral malaria    inclusion body myositis
idiopathic pulmonary fibrosis    malaria


Find genes that share disorders with CXCL11           About GenesLikeMe

Selected Novoseek inferred disease relationships for CXCL11 gene (see all 17)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation 54.2 12 17363734 (1), 16378910 (1), 19155971 (1), 11208713 (1) (see all 9)
multiple sclerosis 40 2 15789559 (1), 12162873 (1)
dermatitis allergic contact 34.2 4 10504443 (2), 10903743 (1), 10233762 (1)
hepatitis c chronic 29.3 1 15653416 (1)
dermatitis 28.2 1 11523046 (1)
necrosis 22.2 9 19095263 (4), 17666446 (1), 20470259 (1), 11208713 (1) (see all 6)
lichen planus 21.4 1 10233762 (1)
mycosis fungoides 20.1 1 10233762 (1)
tumors 19.2 23 16783574 (3), 19095263 (3), 20470259 (1), 11208713 (1) (see all 11)
rheumatoid arthritis 15.4 1 18793417 (1)

Genetic Association Database (GAD): CXCL11
Human Genome Epidemiology (HuGE) Navigator: CXCL11 (4 documents)

Export disorders for CXCL11 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CXCL11 gene, integrated from 10 sources (see all 239):
(articles sorted by number of sources associating them with CXCL11)
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world of online information

  1. The human gene encoding SCYB9B, a putative novel CXC chemokine, maps to human chromosome 4q21 like the closely related genes for MIG (SCYB9) and INP10 (SCYB10). (PubMed id 9730616)1, 2, 3 Erdel M.... Werner-Felmayer G. (Cytogenet. Cell Genet. 1998)
  2. Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. (PubMed id 9625760)1, 2, 9 Cole K.E....Neote K. (J. Exp. Med. 1998)
  3. Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha. (PubMed id 8798467)1, 2, 9 Rani M.R.S....Ransohoff R.M. (J. Biol. Chem. 1996)
  4. Structure and expression of the human small cytokine B subfamily member 11 (SCYB11/formerly SCYB9B, alias I-TAC) gene cloned from IFN- gamma-treated human monocytes (THP-1). (PubMed id 10386863)1, 2, 9 Laich A.M.... Werner-Felmayer G. (J. Interferon Cytokine Res. 1999)
  5. NMR structure of CXCR3 binding chemokine CXCL11 (ITAC). (PubMed id 15273303)1, 2, 9 Booth V.... Sykes B.D. (Protein Sci. 2004)
  6. Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation. (PubMed id 18645041)1, 2, 9 Loos T.... Proost P. (Blood 2008)
  7. Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3). (PubMed id 10233762)1, 2, 9 Tensen C.P.... Willemze R. (J. Invest. Dermatol. 1999)
  8. Genomic organization, sequence and transcriptional regulation of the human CXCL 11 gene. (PubMed id 10395932)1, 2, 9 Tensen C.P.... Willemze R. (Biochim. Biophys. Acta 1999)
  9. Strong overexpression of CXCR3 axis components in childhood inflammatory bowel disease. (PubMed id 20848514)1, 4 Schroepf S....Lacher M. (Inflamm. Bowel Dis. 2010)
  10. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
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  Query String
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6373 HGNC: 10638 AceView: CXCL11 Ensembl:ENSG00000169248 euGenes: HUgn6373
ECgene: CXCL11 Kegg: 6373 H-InvDB: CXCL11

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CXCL11 Pharmacogenomics, SNPs, Pathways
Wikipedia http://en.wikipedia.org/wiki/CXCL11

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CXCL11 gene:
Search GeneIP for patents involving CXCL11

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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