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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CXCL11 Gene

protein-coding   GIFtS: 65
GCID: GC04M076954

Chemokine (C-X-C Motif) Ligand 11

(Previous names: small inducible cytokine subfamily B (Cys-X-Cys), member...)
(Previous symbols: SCYB9B, SCYB11)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chemokine (C-X-C Motif) Ligand 111 2     IP-92 3
SCYB111 2 3 5     IP92 5
SCYB9B1 2 3 5     b-R12
Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 111 2     beta-R12
Interferon Gamma-Inducible Protein 92 3     C-X-C Motif Chemokine 112
Interferon-Inducible T-Cell Alpha Chemoattractant2 3     Small Inducible Cytokine B112
Small-Inducible Cytokine B112 3     Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 9B2
H1742 3     Beta-R13
I-TAC2 3     ITAC3

External Ids:    HGNC: 106381   Entrez Gene: 63732   Ensembl: ENSG000001692487   OMIM: 6048525   UniProtKB: O146253   

Export aliases for CXCL11 gene to outside databases

Previous GC identifers: GC04M076850 GC04M077145 GC04M077347 GC04M077413 GC04M077312 GC04M072707


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CXCL11 Gene:
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that
regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G
protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function
of the immune system, and they have effects on cells of the central nervous system as well as on endothelial
cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This
gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in
activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons
and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma
is a potent inducer of transcription of this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CXCL11 Gene: 
CXCL11 (chemokine (C-X-C motif) ligand 11) is a protein-coding gene. Diseases associated with CXCL11 include hypothyroidism, autoimmune, and vernal keratoconjunctivitis, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Immune response TLR signaling pathways. GO annotations related to this gene include chemokine activity.

UniProtKB/Swiss-Prot: CXL11_HUMAN, O14625
Function: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes.
Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which
involve T-cell recruitment. May play a role in skin immune responses

Gene Wiki entry for CXCL11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CXCL11 gene promoter:
         AML1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXCL11 promoter sequence
   Search SABiosciences Chromatin IP Primers for CXCL11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCL11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.2   Ensembl cytogenetic band:  4q21.1   HGNC cytogenetic band: 4q21

CXCL11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCL11 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M076954:  view genomic region     (about GC identifiers)

Start:
76,954,835 bp from pter      End:
76,962,568 bp from pter
Size:
7,734 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CXL11_HUMAN, O14625 (See protein sequence)
Recommended Name: C-X-C motif chemokine 11 precursor  
Size: 94 amino acids; 10365 Da
Subcellular location: Secreted
Mass spectrometry: Mass=8303; Method=MALDI; Range=22-94; Source=PubMed:10233762;
Sequence caution: Sequence=AAB17374.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for CXCL11:
1RJT (3D)    
Secondary accessions: Q53YA3 Q92840

Explore the universe of human proteins at neXtProt for CXCL11: NX_O14625

Explore proteomics data for CXCL11 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O14625

  • CXCL11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CXCL11 Protein Expression
    REFSEQ proteins: NP_005400.1  
    ENSEMBL proteins: 
     ENSP00000306884   ENSP00000425819  
    Reactome Protein details: O14625
    Human Recombinant Protein Products for CXCL11: 
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    R&D Systems Recombinant & Natural Proteins for CXCL11 (CXCL11/I-TAC)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CXCL11
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CXCL11
    GenScript Purified and Recombinant Proteins for CXCL11
    Novus Biologicals CXCL11 Proteins
    Novus Biologicals CXCL11 Lysates
    Sino Biological Recombinant Protein for CXCL11
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CXCL11
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    CXCL11 for ontologies           About GeneDecksing



    CXCL11 Antibody Products: 
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    Novus Biologicals CXCL11 Antibodies
    Abcam antibodies for CXCL11
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    LSBio Antibodies in human, mouse, rat for CXCL11 

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    GenScript Custom Assay Services for CXCL11
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands

    4 InterPro protein domains:
     IPR027221 CXCL11
     IPR001811 Chemokine_IL8-like_dom
     IPR001089 Chemokine_CXC
     IPR018048 Chemokine_CXC_CS

    Graphical View of Domain Structure for InterPro Entry O14625

    ProtoNet protein and cluster: O14625

    UniProtKB/Swiss-Prot: CXL11_HUMAN, O14625
    Similarity: Belongs to the intercrine alpha (chemokine CxC) family


    CXCL11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CXL11_HUMAN, O14625
    Function: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes.
    Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which
    involve T-cell recruitment. May play a role in skin immune responses
    Induction: By IFNG/IFN-gamma and IFNB1/IFN-beta. Induction by IFNG/IFN-gamma is enhanced by TNF in monocytes,
    dermal fibroblasts and endothelial cells, and by IL1/interleukin-1 in astrocytes

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18275857
    GO:0008009chemokine activity IEA--
         
    CXCL11 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CXCL11:
     Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CXCL11 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CXCL11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CXCL11 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CXCL11 

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    SwitchGear 3'UTR luciferase reporter plasmidCXCL11 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: CXCL11 (NM_005409)
    Sino Biological Human cDNA Clone for CXCL11
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL11
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                         Customized lentivirus expression plasmids for stable overexpression of CXCL11 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL11


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CXCL11 About   (see all 12)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    IL-6 Pathway0.61
    MIF Regulation of Innate Immune Cells0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43
    2Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response0.94
    Immune response TLR signaling pathways0.94
    3Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.93
    4Chemokine Signaling
    Chemokine Signaling0.33
    Chemokine signaling pathway0.33
    5Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CXCL11
        Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response

    5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CXCL11 (see all 17)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    MIF Mediated Glucocorticoid Regulation

    1 GeneGo (Thomson Reuters) Pathway for CXCL11
        Immune response TLR signaling pathways

    2 BioSystems Pathways for CXCL11
        Toll-like receptor signaling pathway
    CXCR3-mediated signaling events


    5/8        Reactome Pathways for CXCL11 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    3         Kegg Pathways  (Kegg details for CXCL11):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Toll-like receptor signaling pathway


    CXCL11 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CXCL11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/155 Interacting proteins for CXCL11 (O146252, 3 ENSP000003068844) via UniProtKB, MINT, STRING, and/or I2D (see all 155)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DPP4P274872, 3, ENSP000003537314MINT-8091131 I2D: score=2 STRING: ENSP00000353731
    CCR3P516773, ENSP000003500034I2D: score=1 STRING: ENSP00000350003
    CXCR3P496823, ENSP000003627954I2D: score=3 STRING: ENSP00000362795
    ACKR3ENSP000002729284STRING: ENSP00000272928
    AGTR2ENSP000003609734STRING: ENSP00000360973
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002690positive regulation of leukocyte chemotaxis IEA--
    GO:0006935chemotaxis IEA--
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0007165signal transduction TAS10233762

    CXCL11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CXCL11 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CXCL11 (CXL11)

    1 HMDB Compound for CXCL11    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    10/11 Novoseek inferred chemical compound relationships for CXCL11 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 73 21 11533168 (2), 11110785 (1), 19397398 (1), 15663962 (1) (see all 17)
    ccl3 63.6 6 12960247 (2), 15178708 (1), 19406226 (1), 19067439 (1) (see all 5)
    tarc 62.2 3 16453150 (2), 11533168 (1)
    ccl4 40.3 6 12960247 (2), 19265171 (1), 19067439 (1), 17912012 (1)
    lysophosphatidylcholine 20.5 2 11795279 (1), 15621055 (1)
    calcium 5.38 15 17363734 (2), 11500837 (2), 15713646 (1), 10825390 (1) (see all 10)
    oligonucleotide 0 1 11533168 (1)
    progesterone 0 2 15557169 (1), 15126579 (1)
    arginine 0 1 16040184 (1)
    dexamethasone 0 3 10092813 (1), 10843686 (1)

    Search CenterWatch for drugs/clinical trials and news about CXCL11 / CXL11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CXCL11 gene: 
    NM_005409.4  

    Unigene Cluster for CXCL11:

    Chemokine (C-X-C motif) ligand 11
    Hs.632592  [show with all ESTs]
    Unigene Representative Sequence: NM_005409
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306621(uc003hjm.3) ENST00000503860
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL11 (see all 18):
    hsa-miR-2052 hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-4263 hsa-miR-3129-5p hsa-miR-221 hsa-miR-9 hsa-miR-3915
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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL11

    Additional mRNA sequence: 

    AF002985.1 AF030514.1 AF352781.1 BC005292.1 BC012532.1 BC110986.1 BT006787.1 U59286.1 
    U66096.1 Y15220.1 

    1 DOTS entry:

    DT.305593 

    24/26 AceView cDNA sequences (see all 26):

    U66096 BX646683 AW802652 AA554678 D62634 AL703031 BX112006 NM_005409 
    BI820123 BQ029949 AA594458 Y15220 BT006787 CB986207 BC005292 AF030514 
    BC012532 BG687080 AA372656 AF002985 BF209312 BF910176 AF352781 AA361853 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CXCL11    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
    SP1:                              
    SP2:                              


    ECgene alternative splicing isoforms for CXCL11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CXCL11 expression in normal human tissues (normalized intensities)      CXCL11 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTATATACT
    CXCL11 Expression
    About this image


    CXCL11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 18 entries
             Thalamus
             Substantia Nigra   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Oral Cavity (Gastrointestinal Tract)    fully expand to see all 2 entries
             mouth   
     
     Lung (Respiratory System)
             alveolar macrophages   
     
     Blood (Respiratory System)
             alveolar macrophages   

    See CXCL11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CXCL11

    SOURCE GeneReport for Unigene cluster: Hs.632592

    UniProtKB/Swiss-Prot: CXL11_HUMAN, O14625
    Tissue specificity: High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in
    thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal
    layer keratinocytes in skin disorders

        SABiosciences Expression via Pathway-Focused PCR Arrays including CXCL11 (see all 10): 
              Antiviral Response in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CXCL11 gene from 2/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cxcl115 chemokine (C-X-C motif) ligand 11   --   5 (46.61 cM) 92359544 
    zebrafish
    (Danio rerio)
    Actinopterygii CXCL11 (1 of 4)6
    cxc646
    (see all 4)
    CXC chemokine 64
    (see all 4)
    37(a)
    30(a)
    (see all 4)
    many → 1
    many → 1
    (see all 4)
    5(43700834-43701312)
    5(40352744-40354399)


    ENSEMBL Gene Tree for CXCL11 (if available)
    TreeFam Gene Tree for CXCL11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CXCL11 gene
    5 SIMAP similar genes for CXCL11 using alignment to 2 protein entries:     CXL11_HUMAN (see all proteins):
    CXCL9    CXCL1    CXCL2    CXCL3    CXCL10

    CXCL11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    4 SNPs in CXCL11 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0487004
    ----see VAR_0487002 N S mis40--------
    rs58594881,2
    C,F--76956289(+) CATACAA/-AAGAG 1 -- int13Minor allele frequency- -:0.20NA CSA 10
    rs574123921,2
    C--76957824(+) TTTTA-/AATTT 
            
    AATTT
    1 -- us2k10--------
    rs105516511,2
    C--76959230(+) TTTAA-/ATTGT 
            
    GCACT
    1 -- us2k11Minor allele frequency- ATTGT:0.00CSA 2

    HapMap Linkage Disequilibrium report for CXCL11 (76954835 - 76962568 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CXCL11:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv27112CNV Gain19812545
    nsv7363OTHER Inversion18451855


    Human Gene Mutation Database (HGMD): CXCL11
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CXCL11
    DNA2.0 Custom Variant and Variant Library Synthesis for CXCL11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604852    OMIM disorders: --

    20/61 diseases for CXCL11 (see all 61):    About MalaCards
    hypothyroidism, autoimmune    vernal keratoconjunctivitis    septic arthritis    nasal cavity adenocarcinoma
    cerebral malaria    relapsing-remitting multiple sclerosis    inclusion body myositis    mycosis fungoides
    optic neuritis    mixed cryoglobulinemia    neuritis    hiv type 1
    idiopathic pulmonary fibrosis    myositis    keratoconjunctivitis    uveitis
    lichen planus    skin disease    tick-borne encephalitis    multiple sclerosis


    CXCL11 for disorders           About GeneDecksing

    10/17 Novoseek inferred disease relationships for CXCL11 gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 54.2 12 17363734 (1), 16378910 (1), 19155971 (1), 11208713 (1) (see all 9)
    multiple sclerosis 40 2 15789559 (1), 12162873 (1)
    dermatitis allergic contact 34.2 4 10504443 (2), 10903743 (1), 10233762 (1)
    hepatitis c chronic 29.3 1 15653416 (1)
    dermatitis 28.2 1 11523046 (1)
    necrosis 22.2 9 19095263 (4), 17666446 (1), 20470259 (1), 11208713 (1) (see all 6)
    lichen planus 21.4 1 10233762 (1)
    mycosis fungoides 20.1 1 10233762 (1)
    tumors 19.2 23 16783574 (3), 19095263 (3), 20470259 (1), 11208713 (1) (see all 11)
    rheumatoid arthritis 15.4 1 18793417 (1)

    Genetic Association Database (GAD): CXCL11
    Human Genome Epidemiology (HuGE) Navigator: CXCL11 (4 documents)

    Export disorders for CXCL11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CXCL11 gene, integrated from 9 sources (see all 237):
    (articles sorted by number of sources associating them with CXCL11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human gene encoding SCYB9B, a putative novel CXC chemokine, maps to human chromosome 4q21 like the closely related genes for MIG (SCYB9) and INP10 (SCYB10). (PubMed id 9730616)1, 2, 3 Erdel M....Werner-Felmayer G. (1998)
    2. Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. (PubMed id 9625760)1, 2, 9 Cole K.E....Neote K. (1998)
    3. Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha. (PubMed id 8798467)1, 2, 9 Rani M.R.S....Ransohoff R.M. (1996)
    4. Structure and expression of the human small cytokine B subfamily member 11 (SCYB11/formerly SCYB9B, alias I-TAC) gene cloned from IFN- gamma-treated human monocytes (THP-1). (PubMed id 10386863)1, 2, 9 Laich A.M.... Werner-Felmayer G. (1999)
    5. NMR structure of CXCR3 binding chemokine CXCL11 (ITAC). (PubMed id 15273303)1, 2, 9 Booth V.... Sykes B.D. (2004)
    6. Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation. (PubMed id 18645041)1, 2, 9 Loos T.... Proost P. (2008)
    7. Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3). (PubMed id 10233762)1, 2, 9 Tensen C.P.... Willemze R. (1999)
    8. Genomic organization, sequence and transcriptional regulation of the human CXCL 11 gene. (PubMed id 10395932)1, 2, 9 Tensen C.P.... Willemze R. (1999)
    9. Strong overexpression of CXCR3 axis components in chi ldhood inflammatory bowel disease. (PubMed id 20848514)1, 4 Schroepf S....Lacher M. (2010)
    10. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6373 HGNC: 10638 AceView: CXCL11 Ensembl:ENSG00000169248 euGenes: HUgn6373
    ECgene: CXCL11 Kegg: 6373 H-InvDB: CXCL11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CXCL11 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CXCL11

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CXCL11 gene:
    Search GeneIP for patents involving CXCL11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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