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Aliases for CXCL11 Gene

Aliases for CXCL11 Gene

  • Chemokine (C-X-C Motif) Ligand 11 2 3
  • SCYB11 3 4 6
  • SCYB9B 3 4 6
  • Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 11 2 3
  • Interferon-Inducible T-Cell Alpha Chemoattractant 3 4
  • Interferon Gamma-Inducible Protein 9 3 4
  • Small-Inducible Cytokine B11 3 4
  • Beta-R1 3 4
  • I-TAC 3 4
  • H174 3 4
  • IP-9 3 4
  • IP9 3 6
  • Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 9B 3
  • Small Inducible Cytokine B11 3
  • C-X-C Motif Chemokine 11 3
  • CXCL11 6
  • B-R1 3
  • ITAC 4

External Ids for CXCL11 Gene

Previous HGNC Symbols for CXCL11 Gene

  • SCYB9B
  • SCYB11

Previous GeneCards Identifiers for CXCL11 Gene

  • GC04M076850
  • GC04M077145
  • GC04M077347
  • GC04M077413
  • GC04M077312
  • GC04M076954
  • GC04M072707

Summaries for CXCL11 Gene

Entrez Gene Summary for CXCL11 Gene

  • Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]

GeneCards Summary for CXCL11 Gene

CXCL11 (Chemokine (C-X-C Motif) Ligand 11) is a Protein Coding gene. Diseases associated with CXCL11 include endotheliitis and autoimmune thyroiditis. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include chemokine activity.

UniProtKB/Swiss-Prot for CXCL11 Gene

  • Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses

Gene Wiki entry for CXCL11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL11 Gene

Genomics for CXCL11 Gene

Regulatory Elements for CXCL11 Gene

Transcription factor binding sites by QIAGEN in the CXCL11 gene promoter:

Genomic Location for CXCL11 Gene

Start:
76,033,682 bp from pter
End:
76,041,415 bp from pter
Size:
7,734 bases
Orientation:
Minus strand

Genomic View for CXCL11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CXCL11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL11 Gene

Proteins for CXCL11 Gene

  • Protein details for CXCL11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14625-CXL11_HUMAN
    Recommended name:
    C-X-C motif chemokine 11
    Protein Accession:
    O14625
    Secondary Accessions:
    • Q53YA3
    • Q92840

    Protein attributes for CXCL11 Gene

    Size:
    94 amino acids
    Molecular mass:
    10365 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB17374.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CXCL11 Gene

neXtProt entry for CXCL11 Gene

Proteomics data for CXCL11 Gene at MOPED

Post-translational modifications for CXCL11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CXCL11 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CXCL11 Gene

Domains for CXCL11 Gene

Gene Families for CXCL11 Gene

HGNC:

Protein Domains for CXCL11 Gene

Suggested Antigen Peptide Sequences for CXCL11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14625

UniProtKB/Swiss-Prot:

CXL11_HUMAN :
  • O14625
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL11: view

Function for CXCL11 Gene

Molecular function for CXCL11 Gene

UniProtKB/Swiss-Prot Function: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses
UniProtKB/Swiss-Prot Induction: By IFNG/IFN-gamma and IFNB1/IFN-beta. Induction by IFNG/IFN-gamma is enhanced by TNF in monocytes, dermal fibroblasts and endothelial cells, and by IL1/interleukin-1 in astrocytes

Gene Ontology (GO) - Molecular Function for CXCL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18275857
GO:0008009 chemokine activity IDA 12782716
GO:0008201 heparin binding IMP 18645041
GO:0048248 CXCR3 chemokine receptor binding IDA 12782716
genes like me logo Genes that share ontologies with CXCL11: view

Phenotypes for CXCL11 Gene

GenomeRNAi human phenotypes for CXCL11:
genes like me logo Genes that share phenotypes with CXCL11: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CXCL11 Gene

Localization for CXCL11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL11 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CXCL11 Gene COMPARTMENTS Subcellular localization image for CXCL11 gene
Compartment Confidence
extracellular 5
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CXCL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with CXCL11: view

Pathways for CXCL11 Gene

genes like me logo Genes that share pathways with CXCL11: view

Gene Ontology (GO) - Biological Process for CXCL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002690 positive regulation of leukocyte chemotaxis IBA --
GO:0006935 chemotaxis IDA 12782716
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IBA --
GO:0007165 signal transduction TAS 10233762
genes like me logo Genes that share ontologies with CXCL11: view

Compounds for CXCL11 Gene

(1) HMDB Compounds for CXCL11 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(11) Novoseek inferred chemical compound relationships for CXCL11 Gene

Compound -log(P) Hits PubMed IDs
rantes 73 18
ccl3 63.6 6
tarc 62.2 3
ccl4 40.3 5
lysophosphatidylcholine 20.5 2
genes like me logo Genes that share compounds with CXCL11: view

Transcripts for CXCL11 Gene

mRNA/cDNA for CXCL11 Gene

Unigene Clusters for CXCL11 Gene

Chemokine (C-X-C motif) ligand 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2:

Relevant External Links for CXCL11 Gene

GeneLoc Exon Structure for
CXCL11
ECgene alternative splicing isoforms for
CXCL11

Expression for CXCL11 Gene

mRNA expression in normal human tissues for CXCL11 Gene

mRNA differential expression in normal tissues according to GTEx for CXCL11 Gene

This gene is overexpressed in Brain - Substantia nigra (18.6) and Pancreas (4.8).

SOURCE GeneReport for Unigene cluster for CXCL11 Gene Hs.632592

mRNA Expression by UniProt/SwissProt for CXCL11 Gene

O14625-CXL11_HUMAN
Tissue specificity: High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders
genes like me logo Genes that share expressions with CXCL11: view

No data available for Protein expression for CXCL11 Gene

Orthologs for CXCL11 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CXCL11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXCL11 35
  • 100 (n)
  • 100 (a)
CXCL11 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CXCL11 35
  • 87.1 (n)
  • 83.87 (a)
CXCL11 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CXCL11 35
  • 86.88 (n)
  • 75.53 (a)
mouse
(Mus musculus)
Mammalia Cxcl11 16
Cxcl11 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CXCL11 36
  • 44 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cxcl11 35
  • 74.11 (n)
  • 63.83 (a)
Species with no ortholog for CXCL11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL11 Gene

ENSEMBL:
Gene Tree for CXCL11 (if available)
TreeFam:
Gene Tree for CXCL11 (if available)

Paralogs for CXCL11 Gene

Selected SIMAP similar genes for CXCL11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CXCL11: view

No data available for Paralogs for CXCL11 Gene

Variants for CXCL11 Gene

Sequence variations from dbSNP and Humsavar for CXCL11 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_048700 -

Structural Variations from Database of Genomic Variants (DGV) for CXCL11 Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER Inversion 18451855
esv27112 CNV Gain 19812545

Relevant External Links for CXCL11 Gene

HapMap Linkage Disequilibrium report
CXCL11
Human Gene Mutation Database (HGMD)
CXCL11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL11 Gene

Disorders for CXCL11 Gene

(17) Novoseek inferred disease relationships for CXCL11 Gene

Disease -log(P) Hits PubMed IDs
inflammation 54.2 9
multiple sclerosis 40 2
dermatitis allergic contact 34.2 4
hepatitis c chronic 29.3 1
dermatitis 28.2 1

Relevant External Links for CXCL11

Genetic Association Database (GAD)
CXCL11
Human Genome Epidemiology (HuGE) Navigator
CXCL11
genes like me logo Genes that share disorders with CXCL11: view

No data available for UniProtKB/Swiss-Prot for CXCL11 Gene

Publications for CXCL11 Gene

  1. Structure and expression of the human small cytokine B subfamily member 11 (SCYB11/formerly SCYB9B, alias I-TAC) gene cloned from IFN- gamma-treated human monocytes (THP-1). (PMID: 10386863) Laich A.M. … Werner-Felmayer G. (J. Interferon Cytokine Res. 1999) 3 4 23
  2. Genomic organization, sequence and transcriptional regulation of the human CXCL 11 gene. (PMID: 10395932) Tensen C.P. … Willemze R. (Biochim. Biophys. Acta 1999) 3 4 23
  3. Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha. (PMID: 8798467) Rani M.R.S. … Ransohoff R.M. (J. Biol. Chem. 1996) 3 4 23
  4. Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. (PMID: 9625760) Cole K.E. … Neote K. (J. Exp. Med. 1998) 3 4 23
  5. Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3). (PMID: 10233762) Tensen C.P. … Willemze R. (J. Invest. Dermatol. 1999) 3 4 23

Products for CXCL11 Gene

Sources for CXCL11 Gene

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