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CXCL10 Gene

protein-coding GIFtS: 62

GC04M077132

chemokine (C-X-C motif) ligand 10
(Previous names: small inducible cytokine subfamily B (Cys-X-Cys), member 10 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: INP10, SCYB10)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
C7 ^¹, ²
Gamma-IP10 ^³
IFI10 ^¹, ²
INP10 ^², ³, ⁵
IP-10 ^¹, ², ³
SCYB10 ^², ³
crg-2 ^¹, ²
gIP-10 ^¹, ²
mob-1 ^¹, ²

Descriptions
10 kDa interferon-gamma-induced protein ^³
Small-inducible cytokine B10 ^³
chemokine (C-X-C motif) ligand 10 ^²
gamma IP10 ^²
interferon-inducible cytokine IP-10 ^²
protein 10 from interferon (gamma)-induced cell line ^²
small inducible cytokine B10 ^²
small inducible cytokine subfamily B (Cys-X-Cys), member 10 ^¹, ²

External Ids
HGNC: 10637¹
Entrez Gene: 3627²
UniProtKB: P02778³
Ensembl: ENSG00000169245⁷

Search outside databases for aliases for CXCL10 gene

Previous GC identifers: GC04M076838 GC04M077335 GC04M077400 GC04M077299

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CXCL10:

This gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of

this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural

killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq]

UniProtKB/Swiss-Prot: CXL10_HUMAN, P02778

Function: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3

Gene Wiki entry for CXCL10

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CXCL10 gene

Entrez Gene cytogenetic band: 4q21 Ensembl cytogenetic band: 4q21.1 HGNC cytogenetic band: 4q21

CXCL10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M077132: (about GC identifiers)

Start:	77,161,295 bp from pter
End:	77,163,674 bp from pter
Size:	2,380 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000004.10 NT_016354.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CXL10_HUMAN, P02778 (See protein sequence)

Recommended Name: C-X-C motif chemokine 10 precursor

Size: 98 amino acids; 10881 Da

Subcellular location: Secreted

Mass spectrometry: Mass=8641.8; Method=Electrospray; Range=22-98; Source=PubMed:11559369;

PDB structures from and Proteopedia :

1LV9 (3D)

1O7Y (3D)

1O7Z (3D)

1O80 (3D)

Secondary accessions: Q96QJ5

Post-translational modifications:

CXCL10(1-73) is produced by proteolytic cleavage after secretion from keratinocytes¹

REFSEQ proteins: NP_001556.2

ENSEMBL proteins:

ENSP00000305651 ENSP00000382408

Human Recombinant Proteins

	Invitrogen human recombinant proteins for CXCL10
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for CXCL10
	R&D Systems Recombinant & Natural Proteins for CXCL10 (CXCL10/IP-10/CRG-2)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (IP10)
	Human Recombinant Proteins from Abnova (CXCL10)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	IEA	--

About this table

Antibodies for CXCL10:

	Invitrogen Antibodies for CXCL10
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for CXCL10
	R&D Systems Antibodies for CXCL10 (CXCL10/IP-10/CRG-2)
	Antibodies from Abcam (IP10), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for CXCL10

Assays for CXCL10:

	Invitrogen Assays for CXCL10
	Millipore Kits and Assays for the Analysis of CXCL10
	R&D Systems ELISAs for CXCL10 (CXCL10/IP-10/CRG-2) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P02778

ProtoNet protein and cluster: P02778

UniProtKB/Swiss-Prot: CXL10_HUMAN, P02778

Similarity: Belongs to the intercrine alpha (chemokine CxC) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CXCL10)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001565

Applied Biosystems Silencer® siRNAs for CXCL10

Sigma-Aldrich siRNA and siRNA Panels for CXCL10

Sigma-Aldrich shRNA Panels and shRNA for CXCL10

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CXCL10
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001565
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001565
untagged cDNA clone in CMV expression vector: NM_001565

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001565

UniProtKB/Swiss-Prot: CXL10_HUMAN, P02778

Function: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3

Induction: By interferon gamma. A diverse population of cell types rapidly increases transcription

of mRNA encoding this protein. This suggests that gamma-induced protein may be a key mediator of

the interferon gamma response

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cxcl10):

hematopoietic system

homeostasis/metabolism

immune system

nervous system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008009	chemokine activity	TAS	10903763
GO:0008603	cAMP-dependent protein kinase regulator activity	TAS	10903763

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for CXCL10 (Your Favorite Gene powered by Ingenuity)

IL-17 Signaling
Thyroid Cancer Signaling
VDR/RXR Activation

GeneDecks CXCL10 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CXCL10

5/116 Interacting proteins for CXCL10 (P02778² ENSP00000305651³) via UniProtKB, MINT, and/or STRING (see all 116 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DPP4	P27487², ENSP00000353731³	MINT-6491454 STRING (score=.882)
DPP8	Q6V1X1²	MINT-6491425
CXCR3	ENSP00000362795³	STRING (score=.999)
IL10	ENSP00000356066³	STRING (score=.987)
IFNG	ENSP00000229135³	STRING (score=.98)

About this table

5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006935	chemotaxis	TAS	10903763
GO:0006954	inflammatory response	TAS	10903763
GO:0006955	immune response	IEA	--
GO:0007166	cell surface receptor linked signal transduction	TAS	10903763
GO:0007267	cell-cell signaling	TAS	3925348

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CXCL10
10/32 Novoseek chemical compound relationships for CXCL10 gene (see all 32 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
rantes	89.49	176	15949333 (4), 11390609 (4), 18385799 (4), 9426952 (4) (see all 99)
ccl3	85.59	41	15480163 (4), 12960247 (2), 16507178 (2), 12538673 (2) (see all 28)
groalpha	78.26	8	15975968 (2), 11163401 (1), 15972545 (1), 9846975 (1) (see all 7)
tarc	77.56	19	12441140 (3), 11310827 (3), 15927812 (3), 15488706 (1) (see all 11)
ccl4	66.61	28	12960247 (2), 12538673 (2), 11178128 (1), 14734774 (1) (see all 22)
ifn-alpha	56.45	5	18240301 (3), 17114181 (1), 16571725 (1)
poly(i-c)	53.84	5	16265667 (1), 16423036 (1), 9858321 (1), 16142732 (1)
luteolin	24.41	1	19426678 (1)
il 10	16.25	3	15975968 (2)
polycarbonate	13.35	1	9139852 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CXCL10)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001565

Sigma-Aldrich siRNA and siRNA Panels for CXCL10

Sigma-Aldrich shRNA Panels and shRNA for CXCL10

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001565

REFSEQ mRNAs for CXCL10 gene:

NM_001565.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001565

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001565
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001565
                                 untagged cDNA clone in CMV expression vector: NM_001565

Additional cDNA sequence:

BC010954.1 X02530.1

3 DOTS entries:

DT.114294 DT.121232720 DT.95156805

24/90 AceView cDNA sequences (see all 90 ):

BC010954 AI681282 BF056337 BF059730 AI924176 AA301018 AI270680 AA301023

AW057871 AA361697 AI241171 CB995581 AA164919 AI378551 AI432694 AW015749

AA557134 AI281493 AA854516 AI683351 AA878880 AA152305 AI299280 AA903517

highest scoring ESTs for CXCL10:

X02530 AA301023 AA361697 AV683665 BC010954 BF574470 BF675259 BG536726 BG537136 BG540497

Unigene Cluster for CXCL10:

Chemokine (C-X-C motif) ligand 10

Hs.632586 [show with all ESTs]

Unigene Representative Sequence: BC010954

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000306602 ENST00000399485

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CXCL10 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CXCL10

¹ / ² / ³

3 probe-sets matching CXCL10 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
431_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X02530	1.00	1.00	1.00	1
204533_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001565	0.60	1.00	0.82	1
204533_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTACATAAGA

SOURCE GeneReport for Unigene cluster: Hs.632586
Expression variation in blood from EXPOLDB for CXCL10

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CXCL10 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CXCL10¹	--	chemokine (C-X-C motif) ligand 10	86.05(n) 77.55(a)	478432 NM_001010949.1 NP_001010949.1
chimpanzee (Pan troglodytes)	CXCL10¹	--	chemokine (C-X-C motif) ligand 10	98.96(n) 100(a)	461242 XM_517217.2 XP_517217.1
cow (Bos taurus)	CXCL10¹	--	chemokine (C-X-C motif) ligand 10	85.07(n) 79.17(a)	615107 NM_001046551.1 NP_001040016.1
rat (Rattus norvegicus)	Cxcl10¹	--	chemokine (C-X-C motif) ligand 10	74.15(n) 67.35(a)	245920 NM_139089.1 NP_620789.1
mouse (Mus musculus)	Cxcl10^{1, 5}	5 (53.00 cM)⁵	chemokine (C-X-C motif) ligand 10^{1, 5}	74.49(n)¹ 68.37(a)¹	15945¹ NM_021274.1¹ NP_067249.1¹ AF227743⁵ AI661308⁵ (see all 33)

About this table Species with no ortholog for CXCL10

ENSEMBL Gene Tree for CXCL10

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CXCL10 gene

CXCL9²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/45 NCBI SNPs in CXCL10 are shown (see all 45 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 56)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs4257674^1,2	A,C,F,H	77164709(+)	`TATTCG/ATAGTA`	1	--	ng3¹		12	EU EA WA NA	981
	rs10014837^1,2	A,C,F,H	77160842(+)	`CCTATA/GGGATA`	1	--	ng5¹		4	EU EA WA	394
	rs8878^1,2	A,C,F,H	77161324(-)	`AAAGAC/TCAAAA`	1	--	ut3¹ ese³		17	NA MN EU EA WA	1628
	rs4386624^1,2	A,C,F,H	77165163(+)	`AAATGC/GAATTT`	1	--	ng3¹		7	EU EA WA NA	560
	rs3921^1,2	A,C,F,H	77161967(-)	`CCAATC/GATGGT`	1	--	ut3¹ ese³		15	MN EU EA WA NA CSAM	1406
	rs4371639^1,2	A,C,F	77165593(+)	`AAGGAT/GATACT`	1	--	ng3¹ trp³		3	NA	138
	rs4309862^1,2	A,C,F	77165005(+)	`ATCCTG/AGGATC`	1	--	ng3¹		3	NA	136
	rs4508917^1,2	C,F,H	77165121(+)	`TAGGAA/GCTCCA`	1	--	ng3¹		4	EU EA WA	420
	rs4256246^1,2	C,F,H	77164546(+)	`CGATGG/AGGTTC`	1	--	ng3¹		8	EU EA WA	836
	rs4417995^1,2	C,F,H	77165023(+)	`TGTACC/TAGGCA`	1	--	ng3¹		4	EU EA WA	420

About this table

HapMap Linkage Disequilibrium images for CXCL10 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 147310

10/95 Novoseek disease relationships for CXCL10 gene (see all 95 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	66.16	40	15108349 (4), 19195322 (3), 9164978 (1), 17475924 (1) (see all 26)
necrosis	63.98	90	18973545 (5), 8798675 (1), 9022006 (1), 9164978 (1) (see all 72)
meningitis viral	49.44	1	9626995 (1)
multiple sclerosis	48.61	12	19225413 (2), 11282170 (2), 16519660 (1), 14760949 (1) (see all 8)
psoriasis	45.58	6	11344355 (2), 9625525 (1), 15149518 (1), 9705166 (1) (see all 5)
tumors	44.99	130	11265771 (6), 18973545 (5), 9064358 (4), 15194051 (3) (see all 81)
virus infection	44.86	21	11431017 (2), 14760949 (2), 17287085 (2), 12663757 (1) (see all 16)
hepatitis c chronic	41.17	9	12794718 (3), 11467655 (2), 18760981 (1), 18775023 (1) (see all 6)
immunopathology	35.15	2	16611912 (1)
autoimmune diseases	34.82	8	17475924 (2), 14607926 (1), 15531503 (1), 8301141 (1) (see all 7)

About this table

Human Gene Mutation Database: CXCL10
Human Genome Epidemiology Navigator: CXCL10 (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/756 PubMed articles for CXCL10 gene (see all 756 ):

Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. (PubMed id 3925348)^{2, 3, 4} Luster A.D....Ravetch J.V. (1985)
Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation. (PubMed id 18645041)^{1, 3, 4} Loos T.... Proost P. (2008)
The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions. (PubMed id 12173928)^{1, 3, 4} Booth V.... Sykes B.D. (2002)
Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8. (PubMed id 8423327)^{1, 3, 4} Proost P....van Damme J. (1993)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Processing of natural and recombinant CXCR3-targeting chemokines and implications for biological activity. (PubMed id 11559369)^{3, 4} Hensbergen P.J.... Tensen C.P. (2001)
Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3). (PubMed id 10233762)^{3, 4} Tensen C.P.... Willemze R. (1999)
Interferon-inducible gene maps to a chromosomal band associated with a (4;11) translocation in acute leukemia cells. (PubMed id 2437586)^{2, 3} Luster A.D....Ravetch J.V. (1987)
Expression of CXC chemokine IP-10 in patients with chronic hepatitis B. (PubMed id 18234638)^{1, 3} Wang J....Xiang G.J. (2008)
IP-10 correlates with hepatitis C viral load, hepatic inflammation and fibrosis and predicts hepatitis C virus relapse or non-response in HIV-HCV coinfection. (PubMed id 19195322)^{1, 3} Reiberger T....Peck-Radosavljevic M. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3627	HGNC: 10637	AceView: CXCL10	Ensembl:ENSG00000169245	euGenes: HUgn3627
ECgene: CXCL10	H-InvDB: CXCL10

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CXCL10	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/CXCL10

Licensable Technologies for CXCL10
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CXCL10:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CXCL10-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CXCL10		Antibodies for CXCL10
	Explore super-pooled esiRNAs		Proteins for CXCL10
	Lentivirus-delivered shRNAs for CXCL10		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CXCL10)
	Search for Antibodies
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (IP10)
	Antibodies (IP10)

Search OriGene for CXCL10

Search Tocris compounds for CXCL10

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CXCL10

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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CXCL10 Gene at Home site.
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CXCL10 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for CXCL10

Summaries
for CXCL10

Genomic Location
for CXCL10

Proteins
for CXCL10

Protein Domains/
Families
for CXCL10

Gene Function
for CXCL10

Pathways & Interactions
for CXCL10

Drugs & Compounds
for CXCL10

Transcripts
for CXCL10

Expression
for CXCL10

Orthologs
for CXCL10

Paralogs
for CXCL10

SNPs/Variants
for CXCL10

Disorders & Mutations
for CXCL10

Medical News
for CXCL10

Publications
for CXCL10

Search for CXCL10

Genome Databases showing CXCL10

Other Databases showing CXCL10

Specialized Databases showing CXCL10

Licensable Technologies
for CXCL10

Services
for CXCL10

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CXCL10 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor CXCL10

Summariesfor CXCL10

Genomic Locationfor CXCL10

Proteinsfor CXCL10

Protein Domains/Familiesfor CXCL10

Gene Functionfor CXCL10

Pathways & Interactionsfor CXCL10

Drugs & Compoundsfor CXCL10

Transcriptsfor CXCL10

Expression for CXCL10

Orthologsfor CXCL10

Paralogsfor CXCL10

SNPs/Variantsfor CXCL10

Disorders & Mutationsfor CXCL10

Medical Newsfor CXCL10

Publicationsfor CXCL10

Search for CXCL10

Genome Databases showing CXCL10

Other Databases showing CXCL10

Specialized Databases showing CXCL10

Licensable Technologiesfor CXCL10

Servicesfor CXCL10

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CXCL10

Summaries
for CXCL10

Genomic Location
for CXCL10

Proteins
for CXCL10

Protein Domains/
Families
for CXCL10

Gene Function
for CXCL10

Pathways & Interactions
for CXCL10

Drugs & Compounds
for CXCL10

Transcripts
for CXCL10

Expression
for CXCL10

Orthologs
for CXCL10

Paralogs
for CXCL10

SNPs/Variants
for CXCL10

Disorders & Mutations
for CXCL10

Medical News
for CXCL10

Publications
for CXCL10

Licensable Technologies
for CXCL10

Services
for CXCL10