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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CXCL10 Gene

protein-coding   GIFtS: 65
GCID: GC04M076942

chemokine (C-X-C motif) ligand 10

(Previous names: small inducible cytokine subfamily B (Cys-X-Cys), member...)
(Previous symbols: INP10, SCYB10)
 Explore 169 diseases affiliated with
CXCL10 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CXCL10    

Aliases
for CXCL10 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chemokine (C-X-C Motif) Ligand 101 2     Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 101 2
INP101 2 3 5     Small-Inducible Cytokine B102 3
IP-101 2 3     10 KDa Interferon Gamma-Induced Protein2 3
SCYB101 2 3     C-X-C Motif Chemokine 102
C71 2     Gamma IP102
IFI101 2     Gamma-IP103
Crg-21     Interferon-Inducible Cytokine IP-102
GIP-101     Protein 10 From Interferon (Gamma)-Induced Cell Line2
Mob-11     Gamma-IP103

External Ids:    HGNC: 106371   Entrez Gene: 36272   Ensembl: ENSG000001692457   OMIM: 1473105   UniProtKB: P027783   

Export aliases for CXCL10 gene to outside databases

Previous GC identifers: GC04M076838 GC04M077132 GC04M077335 GC04M077400 GC04M077299 GC04M072694


Summaries
for CXCL10 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CXCL10:
This gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3
results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and
modulation of adhesion molecule expression. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CXL10_HUMAN, P02778
Function: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3

Gene Wiki entry for CXCL10


Genomic Views
for CXCL10 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CXCL10 gene promoter:
         AML1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CXCL10 promoter sequence
   Search SABiosciences Chromatin IP Primers for CXCL10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCL10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q21.1   HGNC cytogenetic band: 4q21

CXCL10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCL10 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M076942:  view genomic region     (about GC identifiers)

Start:
 76,942,271 bp from pter      End:
 76,944,650 bp from pter
Size:
 2,380 bases      Orientation:
 minus strand

Proteins
for CXCL10 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CXL10_HUMAN, P02778 (See protein sequence)
Recommended Name: C-X-C motif chemokine 10 precursor  
Size: 98 amino acids; 10881 Da
Subcellular location: Secreted
Mass spectrometry: Mass=8641.8; Method=Electrospray; Range=22-98; Source=PubMed:11559369;
4 PDB 3D structures from and Proteopedia for CXCL10:
1LV9 (3D)        1O7Y (3D)        1O7Z (3D)        1O80 (3D)    
Secondary accessions: Q96QJ5

Explore the universe of human proteins at neXtProt for CXCL10: NX_P02778

Post-translational modifications:

  • CXCL10(1-73) is produced by proteolytic cleavage after secretion from keratinocytes1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P02778

    • CXCL10 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001556.2  
    ENSEMBL proteins: 
     ENSP00000305651  
    Reactome Protein details: P02778
    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for CXCL10 (CXCL10/IP-10/CRG-2)
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    OriGene Purified Protein: CXCL10
    OriGene Protein Over-expression Lysate: CXCL10
    OriGene Custom Protein Services for CXCL10 
    GenScript Purified and Recombinant Proteins for CXCL10
    Novus Biologicals CXCL10 Proteins
    Novus Biologicals CXCL10 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CXCL10
    Uscn Proteins for CXCL10

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0009897external side of plasma membrane IEA--


    CXCL10 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CXCL10

    Protein Domains /
    Families
    for CXCL10 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CXCL10 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001811 Chemokine_IL8-like_dom
     IPR001089 Chemokine_CXC
     IPR027220 Chemokine_CXCL10
     IPR018048 Chemokine_CXC_CS

    Graphical View of Domain Structure for InterPro Entry P02778

    ProtoNet protein and cluster: P02778

    UniProtKB/Swiss-Prot: CXL10_HUMAN, P02778
    Similarity: Belongs to the intercrine alpha (chemokine CxC) family


    Function
    for CXCL10 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CXL10_HUMAN, P02778
    Function: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3
    Induction: By IFNG/IFN-gamma. A diverse population of cell types rapidly increases transcription of mRNA encoding this
    protein. This suggests that gamma-induced protein may be a key mediator of the IFNG/IFN-gamma response

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCL10
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL10 (see all 12):
    hsa-miR-15a hsa-miR-503 hsa-let-7a-2* hsa-miR-497 hsa-miR-570 hsa-miR-646 hsa-miR-424 hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmid: CXCL10 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXCL10 (see all 7)
    OriGene shRNA RFP: CXCL10
    OriGene siRNA: CXCL10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCL10

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CXCL10

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL10 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL10
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL10 

    Cell Line
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    Search LifeMap BioReagents cell lines for CXCL10

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL10

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS10201891
    GO:0008009chemokine activity IEA--
    GO:0008603cAMP-dependent protein kinase regulator activity TAS10903763


    CXCL10 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CXCL10:
     Synthetic lethal with c-Myc af 

    Animal Models:
         Mouse knock-out Cxcl10tm1Adl for CXCL10
         7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cxcl10):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  nervous system 

    CXCL10 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CXCL10 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    8/9 pathways (see all 9)
    		PEDF Induced Signaling1.00
    		RAR-Gamma-RXR-Alpha Degradation0.54
    		MIF Mediated Glucocorticoid Regulation0.73
    		STAT3 Pathway0.47
    		MIF Regulation of Innate Immune Cells0.71
    		Endothelin-1 Signaling Pathway0.44
    		IL-6 Pathway0.61
    		Cytokine-cytokine receptor interaction0.26
    2Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		Peptide ligand-binding receptors0.61
    		GPCR ligand binding0.75
    		G alpha (i) signalling events0.44
    3Rho Family GTPases
    		Rho Family GTPases1.00
    		Molecular Mechanisms of Cancer0.51
    		ERK Signaling0.61
    4Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    5Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    		Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response1.00
    		Immune response_TLR signaling pathways0.94

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CXCL10
        Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response

    5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CXCL10 (see all 17)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    MIF Mediated Glucocorticoid Regulation

    1 GeneGo (Thomson Reuters) Pathway for CXCL10
        Immune response TLR signaling pathways

    3 BioSystems Pathways for CXCL10 
        Type II interferon signaling (IFNG)
    Toll-like receptor signaling pathway
    CXCR3-mediated signaling events

    5/8        Reactome Pathways for CXCL10 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    5/6         Kegg Pathways  (Kegg details for CXCL10) (see all 6):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Toll-like receptor signaling pathway
    RIG-I-like receptor signaling pathway
    Cytosolic DNA-sensing pathway


    CXCL10 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CXCL10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/160 Interacting proteins for CXCL10 (P027782, 3 ENSP000003056514) via UniProtKB, MINT, STRING, and/or I2D (see all 160)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DPP4P274872, 3, ENSP000003537314MINT-8091106 I2D: score=2 STRING: ENSP00000353731
    IGFBP7Q162703, ENSP000002956664I2D: score=3 STRING: ENSP00000295666
    VCANP136113, ENSP000002650774I2D: score=3 STRING: ENSP00000265077
    CCR3P516773, ENSP000003500034I2D: score=1 STRING: ENSP00000350003
    CXCR3P496823, ENSP000003627954I2D: score=4 STRING: ENSP00000362795
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002690positive regulation of leukocyte chemotaxis IEA--
    GO:0006935chemotaxis IEA--
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0007165signal transduction TAS10201891


    CXCL10 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CXCL10 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CXCL10 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CXCL10

    1 DrugBank Compound for CXCL10    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    N-Methylleucine-- --target--17139284 17016423

    10/56 Novoseek chemical compound relationships for CXCL10 gene (see all 56)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 89.4 190 15949333 (4), 11390609 (4), 18385799 (4), 9426952 (4) (see all 99)
    ccl3 86.2 51 15480163 (4), 19906920 (2), 12960247 (2), 20205697 (2) (see all 36)
    groalpha 76.7 8 15975968 (2), 11163401 (1), 15972545 (1), 9846975 (1) (see all 7)
    tarc 75.8 19 12441140 (3), 11310827 (3), 15927812 (3), 15488706 (1) (see all 11)
    ccl4 68.5 34 12960247 (2), 12538673 (2), 11178128 (1), 14734774 (1) (see all 28)
    ifn-alpha 53.9 5 18240301 (3), 17114181 (1), 16571725 (1)
    polyinosinic-polycytidylic acid 53.5 4 16265667 (1), 16966508 (1), 18941247 (1), 20231782 (1)
    poly(i-c) 52 5 16265667 (1), 16423036 (1), 9858321 (1), 16142732 (1)
    2',5'-oligoadenylate 48.7 4 17428863 (1), 16423036 (1), 15320959 (1)
    vegf 45.7 46 18385799 (6), 11890674 (4), 19700197 (3), 19549024 (2) (see all 27)

    Search CenterWatch for drugs/clinical trials and news about CXCL10 / CXL10 

    Transcripts
    for CXCL10 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CXCL10 gene: 
    NM_001565.3  

    Unigene Cluster for CXCL10:

    Chemokine (C-X-C motif) ligand 10
    Hs.632586  [show with all ESTs]
    Unigene Representative Sequence: NM_001565
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000306602(uc003hjl.4)

    miRNA
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    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL10 (see all 12):
    hsa-miR-15a hsa-miR-503 hsa-let-7a-2* hsa-miR-497 hsa-miR-570 hsa-miR-646 hsa-miR-424 hsa-let-7g*
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    BC010954.1 X02530.1 

    3 DOTS entries:

    DT.114294  DT.121232720  DT.95156805 

    24/90 AceView cDNA sequences (see all 90):

    AA301018 AW057871 BF056337 AA164919 AA301023 AA361697 AI270680 CB995581 
    AI681282 AI241171 BF059730 BC010954 AI924176 BG537136 CB957011 AI338979 
    CB956704 CB997833 BG620826 NM_001565 AA854516 AV683665 BV183902 AW516440 

    GeneLoc Exon Structure


    Expression
    for CXCL10 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CXCL10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTACATAAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CXCL10 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartMyocardiumCardiac FibroblastsEpicardium
    TestisSeminiferous TubulesSertoli cellsTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Epiblast-like cells (Reconstitution of mo...)

    See CXCL10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CXCL10

    SOURCE GeneReport for Unigene cluster: Hs.632586
        SABiosciences Expression via Pathway-Focused PCR Arrays including CXCL10 (see all 18): 
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Interferons & Receptors in human mouse rat
              Chemokines & Receptors in human mouse rat
              Nephrotoxicity in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL10

    Orthologs
    for CXCL10 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CXCL10 gene from 1/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    zebrafish
    (Danio rerio)    		 Actinopterygii si:ch211-202a12.76
    cxc646
    (see all 4)    		 CXC chemokine 64
    (see all 4)    		 37(a)
    33(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 5(43700834-43701312)
    5(40352744-40354399)


    ENSEMBL Gene Tree for CXCL10 (if available)
    TreeFam Gene Tree for CXCL10 (if available) 

    Paralogs
    for CXCL10 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CXCL10 gene
    CXCL92  
    12 SIMAP similar genes for CXCL10 using alignment to 1 protein entry:     CXL10_HUMAN:
    PF4    PF4V1    CXCL2    CXCL6    CXCL9    CXCL1
    CXCL3    CXCL12    CXCL13    CXCL5    CXCL11    IL8

    CXCL10 for paralogs           About GeneDecksing



    Genomic Variants
    for CXCL10 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Human Gene Mutation Database (HGMD): CXCL10
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CXCL10
    DNA2.0 Custom Variant and Variant Library Synthesis for CXCL10

    Disorders / Diseases
    for CXCL10 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CXCL10 for disorders           About GeneDecksing

    OMIM gene information: 147310    OMIM disorders: --

    20/169 diseases for CXCL10 (see all 169):    About MalaCards
    subacute sclerosing panencephalitis    disseminated intravascular coagulation    hypersensitivity reaction type ii disease    sydenham's chorea
    proliferative diabetic retinopathy    cystoid macular edema    west nile virus    mycosis fungoides
    graft versus host disease    corneal neovascularization    bronchiolitis obliterans    lichen planus
    allergic contact dermatitis    contact dermatitis    retinal vein occlusion    oral lichen planus
    biliary atresia    severe acute respiratory syndrome    invasive aspergillosis    type 2 diabetes mellitus

    12 diseases from the University of Copenhagen DISEASES database for CXCL10:
    Multiple sclerosis     Tuberculosis     Hypersensitivity reaction type II disease     Encephalitis
    Cancer     Asthma     Influenza     Severe acute respiratory syndrome
    Hepatitis C     Pneumonia     Dermatitis     Arthritis

    10/95 Novoseek disease relationships for CXCL10 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 68.3 43 15108349 (4), 19195322 (3), 9164978 (1), 17475924 (1) (see all 29)
    necrosis 65.9 105 18973545 (5), 8798675 (1), 9022006 (1), 9164978 (1) (see all 85)
    multiple sclerosis 48.4 12 19225413 (2), 11282170 (2), 16519660 (1), 14760949 (1) (see all 8)
    virus infection 47.8 23 11431017 (2), 14760949 (2), 17287085 (2), 12663757 (1) (see all 18)
    meningitis viral 47.2 1 9626995 (1)
    tumors 46.5 141 11265771 (6), 18973545 (5), 9064358 (4), 15194051 (3) (see all 92)
    hepatitis c chronic 45.4 13 12794718 (3), 11467655 (2), 20186843 (2), 19918044 (1) (see all 8)
    psoriasis 44.9 6 11344355 (2), 9625525 (1), 15149518 (1), 9705166 (1) (see all 5)
    autoimmune diseases 38.2 8 17475924 (2), 14607926 (1), 15531503 (1), 8301141 (1) (see all 7)
    hepatitis c 35.6 21 18760981 (4), 17389454 (2), 18775023 (2), 19195322 (2) (see all 8)

    Human Genome Epidemiology (HuGE) Navigator: CXCL10 (17 documents)

    Export disorders for CXCL10 gene to outside databases

    Publications
    for CXCL10 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CXCL10 gene, integrated from 9 sources (see all 973):
    (articles sorted by number of sources associating them with CXCL10)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. (PubMed id 3925348)1, 2, 3 Luster A.D....Ravetch J.V. (1985)
    2. Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation. (PubMed id 18645041)1, 2, 9 Loos T.... Proost P. (2008)
    3. The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions. (PubMed id 12173928)1, 2, 9 Booth V.... Sykes B.D. (2002)
    4. Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8. (PubMed id 8423327)1, 2, 9 Proost P....van Damme J. (1993)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Processing of natural and recombinant CXCR3-targeting chemokines and implications for biological activity. (PubMed id 11559369)1, 2 Hensbergen P.J.... Tensen C.P. (2001)
    7. Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3). (PubMed id 10233762)1, 2 Tensen C.P.... Willemze R. (1999)
    8. Interferon-inducible gene maps to a chromosomal band associated with a (4;11) translocation in acute leukemia cells. (PubMed id 2437586)1, 3 Luster A.D....Ravetch J.V. (1987)
    9. Relationship between the expression of IP-10 and IP-1 0 mRNA in peripheral blood and HBV DNA level in patients with cirrhosis. (PubMed id 20525556)1, 9 Wang J....Hu X.B. (2010)
    10. Expression of CXC chemokine IP-10 in patients with chronic hepatitis B. (PubMed id 18234638)1, 9 Wang J....Xiang G.J. (2008)

    External Searches for CXCL10 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing CXCL10 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3627 HGNC: 10637 AceView: CXCL10 Ensembl:ENSG00000169245 euGenes: HUgn3627
    ECgene: CXCL10 Kegg: 3627 H-InvDB: CXCL10

    Other Databases showing CXCL10 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CXCL10 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CXCL10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CXCL10 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CXCL10

    Intellectual Property
    for CXCL10 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CXCL10 gene:
    Search GeneIP for patents involving CXCL10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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