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CXCL10 Gene

protein-coding   GIFtS: 63
GCID: GC04M076942

Chemokine (C-X-C Motif) Ligand 10

(Previous names: small inducible cytokine subfamily B (Cys-X-Cys), member...)
(Previous symbols: INP10, SCYB10)
  See CXCL10-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-X-C Motif) Ligand 101 2     C-X-C Motif Chemokine 102
INP101 2 3 5     crg-22
SCYB101 2 3     gIP-102
Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 101 2     Gamma IP102
Small-Inducible Cytokine B102 3     gamma-IP102
10 KDa Interferon Gamma-Induced Protein2 3     Interferon-Inducible Cytokine IP-102
IP-102 3     mob-12
C72     Protein 10 From Interferon (Gamma)-Induced Cell Line2
IFI102     Gamma-IP103

External Ids:    HGNC: 106371   Entrez Gene: 36272   Ensembl: ENSG000001692457   OMIM: 1473105   UniProtKB: P027783   

Export aliases for CXCL10 gene to outside databases

Previous GC identifers: GC04M076838 GC04M077132 GC04M077335 GC04M077400 GC04M077299 GC04M072694


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CXCL10 Gene:
This gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to
CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration,
and modulation of adhesion molecule expression. (provided by RefSeq, Jul 2008)

GeneCards Summary for CXCL10 Gene:
CXCL10 (chemokine (C-X-C motif) ligand 10) is a protein-coding gene. Diseases associated with CXCL10 include peritoneal carcinoma, and cystoid macular edema. GO annotations related to this gene include cAMP-dependent protein kinase regulator activity and receptor binding. An important paralog of this gene is CXCL9.

UniProtKB/Swiss-Prot: CXL10_HUMAN, P02778
Function: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3

Gene Wiki entry for CXCL10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CXCL10 gene promoter:
         AML1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXCL10 promoter sequence
   Search Chromatin IP Primers for CXCL10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CXCL10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q21.1   HGNC cytogenetic band: 4q21

CXCL10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCL10 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M076942:  view genomic region     (about GC identifiers)

Start:
76,942,269 bp from pter      End:
76,944,689 bp from pter
Size:
2,421 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CXL10_HUMAN, P02778 (See protein sequence)
Recommended Name: C-X-C motif chemokine 10 precursor  
Size: 98 amino acids; 10881 Da
Mass spectrometry: Mass=8641.8; Method=Electrospray; Range=22-98; Source=PubMed:11559369;
4 PDB 3D structures from and Proteopedia for CXCL10:
1LV9 (3D)        1O7Y (3D)        1O7Z (3D)        1O80 (3D)    
Secondary accessions: Q96QJ5

Explore the universe of human proteins at neXtProt for CXCL10: NX_P02778

Explore proteomics data for CXCL10 at MOPED

Post-translational modifications: 

  • CXCL10(1-73) is produced by proteolytic cleavage after secretion from keratinocytes1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CXCL10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001556.2  
    ENSEMBL proteins: 
     ENSP00000305651  
    Reactome Protein details: P02778

    CXCL10 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CXCL10 (CXCL10/IP-10/CRG-2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for CXCL10
    OriGene Protein Over-expression Lysate for CXCL10
    OriGene MassSpec for CXCL10
    OriGene Custom Protein Services for CXCL10
    GenScript Purified and Recombinant Proteins for CXCL10
    Novus Biologicals CXCL10 Proteins
    Novus Biologicals CXCL10 Lysates
    Sino Biological Recombinant Protein for CXCL10
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CXCL10
    Browse Proteins at Cloud-Clone Corp.

     
    eBioscience Proteins for CXCL10: (see all 2
                        Human CXCL10 (IP-10) Recombinant Protein 5 ug

     
    antibodies-online proteins for CXCL10 (81 products) 

     
    Search antibodies-online for peptides for CXCL10

    CXCL10 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CXCL10
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    Abcam antibodies for CXCL10
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CXCL10
    antibodies-online antibodies for CXCL10 (163 products) 

    CXCL10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for CXCL10 (CXCL10/IP-10/CRG-2)         (see all)
    GenScript Custom Assay Services for CXCL10
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    eBioscience ELISAs for CXCL10:  
                        Human IP-10 Instant ELISA 128 tests
    antibodies-online kits for CXCL10 (68 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    4 InterPro protein domains:
     IPR001811 Chemokine_IL8-like_dom
     IPR001089 Chemokine_CXC
     IPR027220 Chemokine_CXCL10/11
     IPR018048 Chemokine_CXC_CS

    Graphical View of Domain Structure for InterPro Entry P02778

    ProtoNet protein and cluster: P02778

    UniProtKB/Swiss-Prot: CXL10_HUMAN, P02778
    Similarity: Belongs to the intercrine alpha (chemokine CxC) family


    Find genes that share domains with CXCL10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CXL10_HUMAN, P02778
    Function: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3
    Induction: By IFNG/IFN-gamma. A diverse population of cell types rapidly increases transcription of mRNA encoding
    this protein. This suggests that gamma-induced protein may be a key mediator of the IFNG/IFN-gamma response

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS10201891
    GO:0005515protein binding IPI18275857
    GO:0008009chemokine activity IDA12782716
    GO:0008201heparin binding IMP18645041
    GO:0008603cAMP-dependent protein kinase regulator activity TAS10903763
         
    Find genes that share ontologies with CXCL10           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CXCL10:
     Synthetic lethal with c-Myc af 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cxcl10):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  nervous system 

    Find genes that share phenotypes with CXCL10           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cxcl10tm1Adl for CXCL10

       genOway: Develop your customized and physiologically relevant rodent model for CXCL10

    miRNA
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    Block miRNA regulation of human, mouse, rat CXCL10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CXCL10 (see all 12):
    hsa-miR-15a hsa-miR-503 hsa-let-7a-2* hsa-miR-497 hsa-miR-570 hsa-miR-646 hsa-miR-424 hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidCXCL10 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CXCL10
    Predesigned siRNA for gene silencing in human, mouse, rat CXCL10

    Gene Editing
    Products:
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    Clone
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    OriGene ORF clones in mouse, rat for CXCL10
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    GenScript: all cDNA clones in your preferred vector: CXCL10 (NM_001565)
    Sino Biological Human cDNA Clone for CXCL10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL10

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    In Situ Assay
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    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA6-13729) for CXCL10 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CXL10_HUMAN, P02778: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    plasma membrane2
    cytoskeleton1
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0009897external side of plasma membrane IEA--

    Find genes that share ontologies with CXCL10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CXCL10 About   (see all 18)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    IL-6 Pathway0.61
    MIF Mediated Glucocorticoid Regulation0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43
    2Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    3Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine receptors bind chemokines0.81
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    4Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    5Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.44


    Find genes that share SuperPaths with CXCL10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CXCL10
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CXCL10 (see all 17)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    MIF Mediated Glucocorticoid Regulation

    1 GeneGo (Thomson Reuters) Pathway for CXCL10
        Immune response TLR signaling pathways

    5 BioSystems Pathways for CXCL10
        Type II interferon signaling (IFNG)
    Spinal Cord Injury
    Toll-like receptor signaling pathway
    CXCR3-mediated signaling events
    Regulation of toll-like receptor signaling pathway


    2 Reactome Pathways for CXCL10
        Chemokine receptors bind chemokines
    G alpha (i) signalling events


    Selected Kegg Pathways  (Kegg details for CXCL10) (see all 7):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Toll-like receptor signaling pathway
    RIG-I-like receptor signaling pathway
    Cytosolic DNA-sensing pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CXCL10 (see all 18): 
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Interferons & Receptors in human mouse rat
              Chemokines & Receptors in human mouse rat
              Nephrotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CXCL10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CXCL10 (P027781, 2, 3 ENSP000003056514) via UniProtKB, MINT, STRING, and/or I2D (see all 160)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DPP4P274871, 2, 3, ENSP000003537314EBI-7815386,EBI-2871277 MINT-8091106 I2D: score=2 STRING: ENSP00000353731
    IGFBP7Q162703, ENSP000002956664I2D: score=3 STRING: ENSP00000295666
    VCANP136113, ENSP000002650774I2D: score=3 STRING: ENSP00000265077
    CCR3P516773, ENSP000003500034I2D: score=1 STRING: ENSP00000350003
    CXCR3P496823, ENSP000003627954I2D: score=4 STRING: ENSP00000362795
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002690positive regulation of leukocyte chemotaxis IEA--
    GO:0006935chemotaxis IDA12782716
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0007165signal transduction TAS10201891

    Find genes that share ontologies with CXCL10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CXCL10 (CXL10)

    1 DrugBank Compound for CXCL10    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    N-Methylleucine-- --target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for CXCL10 gene (see all 56)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 89.4 190 15949333 (4), 11390609 (4), 18385799 (4), 9426952 (4) (see all 99)
    ccl3 86.2 51 15480163 (4), 19906920 (2), 12960247 (2), 20205697 (2) (see all 36)
    groalpha 76.7 8 15975968 (2), 11163401 (1), 15972545 (1), 9846975 (1) (see all 7)
    tarc 75.8 19 12441140 (3), 11310827 (3), 15927812 (3), 15488706 (1) (see all 11)
    ccl4 68.5 34 12960247 (2), 12538673 (2), 11178128 (1), 14734774 (1) (see all 28)
    ifn-alpha 53.9 5 18240301 (3), 17114181 (1), 16571725 (1)
    polyinosinic-polycytidylic acid 53.5 4 16265667 (1), 16966508 (1), 18941247 (1), 20231782 (1)
    poly(i-c) 52 5 16265667 (1), 16423036 (1), 9858321 (1), 16142732 (1)
    2',5'-oligoadenylate 48.7 4 17428863 (1), 16423036 (1), 15320959 (1)
    vegf 45.7 46 18385799 (6), 11890674 (4), 19700197 (3), 19549024 (2) (see all 27)



    Find genes that share compounds with CXCL10           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CXCL10 gene: 
    NM_001565.3  

    Unigene Cluster for CXCL10:

    Chemokine (C-X-C motif) ligand 10
    Hs.632586  [show with all ESTs]
    Unigene Representative Sequence: NM_001565
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000306602(uc003hjl.4)
    miRNA
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    hsa-miR-15a hsa-miR-503 hsa-let-7a-2* hsa-miR-497 hsa-miR-570 hsa-miR-646 hsa-miR-424 hsa-let-7g*
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat CXCL10
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    Additional mRNA sequence: 

    BC010954.1 X02530.1 

    3 DOTS entries:

    DT.114294  DT.121232720  DT.95156805 

    Selected AceView cDNA sequences (see all 90):

    AA301018 AA361697 AI241171 AI270680 BF056337 AI924176 AA301023 CB995581 
    BC010954 BF059730 AI681282 AW057871 AA164919 CB984591 AI702669 CD700907 
    AI299928 AI338979 AA854516 BG620826 BG536726 AA152305 AI299280 AI739064 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CXCL10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACATAAGA
    CXCL10 Expression
    About this image


    CXCL10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Thymus (Hematopoietic System)
             Thymus
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
    CXCL10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CXCL10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632586
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CXCL10 (see all 18): 
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Interferons & Receptors in human mouse rat
              Chemokines & Receptors in human mouse rat
              Nephrotoxicity in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for CXCL10 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cxcl101 , 5 chemokine (C-X-C motif) ligand 101, 5 74.49(n)1
    68.37(a)1
      5 (46.57 cM)5
    159451  NM_021274.21  NP_067249.11 
     923466385 


    ENSEMBL Gene Tree for CXCL10 (if available)
    TreeFam Gene Tree for CXCL10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CXCL10 gene
    CXCL92  
    12 SIMAP similar genes for CXCL10 using alignment to 1 protein entry:     CXL10_HUMAN:
    PF4    PF4V1    CXCL2    CXCL6    CXCL9    CXCL1
    CXCL3    CXCL12    CXCL13    CXCL5    CXCL11    IL8

    Find genes that share paralogs with CXCL10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CXCL10:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7363OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): CXCL10
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CXCL10
    DNA2.0 Custom Variant and Variant Library Synthesis for CXCL10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147310    OMIM disorders: --

    Selected diseases for CXCL10 (see all 29):    
    About MalaCards
    peritoneal carcinoma    cystoid macular edema    endotheliitis    nodular goiter
    primary peritoneal carcinoma    sydenham's chorea    viral encephalitis    tendinosis
    paracoccidioidomycosis    newcastle disease    severe acute respiratory syndrome    autoimmune thyroiditis
    legionnaires' disease    yellow fever    cryptosporidiosis    bronchiolitis obliterans
    corneal neovascularization    invasive aspergillosis    japanese encephalitis    encephalitis

    11 diseases from the University of Copenhagen DISEASES database for CXCL10:
    Multiple sclerosis     Tuberculosis     Hypersensitivity reaction type II disease     Encephalitis
    Asthma     Severe acute respiratory syndrome     Influenza     Hepatitis C
    Pneumonia     Dermatitis     Arthritis

    Find genes that share disorders with CXCL10           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CXCL10 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 68.3 43 15108349 (4), 19195322 (3), 9164978 (1), 17475924 (1) (see all 29)
    necrosis 65.9 105 18973545 (5), 8798675 (1), 9022006 (1), 9164978 (1) (see all 85)
    multiple sclerosis 48.4 12 19225413 (2), 11282170 (2), 16519660 (1), 14760949 (1) (see all 8)
    virus infection 47.8 23 11431017 (2), 14760949 (2), 17287085 (2), 12663757 (1) (see all 18)
    meningitis viral 47.2 1 9626995 (1)
    tumors 46.5 141 11265771 (6), 18973545 (5), 9064358 (4), 15194051 (3) (see all 92)
    hepatitis c chronic 45.4 13 12794718 (3), 11467655 (2), 20186843 (2), 19918044 (1) (see all 8)
    psoriasis 44.9 6 11344355 (2), 9625525 (1), 15149518 (1), 9705166 (1) (see all 5)
    autoimmune diseases 38.2 8 17475924 (2), 14607926 (1), 15531503 (1), 8301141 (1) (see all 7)
    hepatitis c 35.6 21 18760981 (4), 17389454 (2), 18775023 (2), 19195322 (2) (see all 8)

    Genetic Association Database (GAD): CXCL10
    Human Genome Epidemiology (HuGE) Navigator: CXCL10 (17 documents)

    Export disorders for CXCL10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CXCL10 gene, integrated from 10 sources (see all 1019):
    (articles sorted by number of sources associating them with CXCL10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. (PubMed id 3925348)1, 2, 3 Luster A.D.... Ravetch J.V. (Nature 1985)
    2. Genetic association between a chemokine gene CXCL-10 (IP-10, interferon gamma inducible protein 10) and susceptibility to tuberculosis. (PubMed id 19523460)1, 4, 9 Tang N.L....Chan C.Y. ( international journal of clinical chemistry 2009)
    3. Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation. (PubMed id 18645041)1, 2, 9 Loos T.... Proost P. (Blood 2008)
    4. The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions. (PubMed id 12173928)1, 2, 9 Booth V.... Sykes B.D. (Biochemistry 2002)
    5. Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8. (PubMed id 8423327)1, 2, 9 Proost P....van Damme J. (J. Immunol. 1993)
    6. A CXC motif ligand 10 polymorphism as a marker to predict severity of Graves' disease. (PubMed id 20187787)1, 4 BrA1ck P....Ramos-Lopez E. (Thyroid 2010)
    7. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (J. Hum. Genet. 2010)
    8. Candidate genes associated with susceptibility for SARS-coronavirus. (PubMed id 19590927)1, 4 Hsieh Y.H....Ho M.S. (Bull. Math. Biol. 2010)
    9. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    10. Association of cytokine and chemokine gene polymorphisms with severe acute respiratory syndrome. (PubMed id 19258635)1, 4 Lau Y.L. and Peiris J.S. (Hong Kong Med J 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3627 HGNC: 10637 AceView: CXCL10 Ensembl:ENSG00000169245 euGenes: HUgn3627
    ECgene: CXCL10 Kegg: 3627 H-InvDB: CXCL10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CXCL10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CXCL10 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CXCL10

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CXCL10 gene:
    Search GeneIP for patents involving CXCL10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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