Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CXCL10 Gene

Aliases for CXCL10 Gene

  • C-X-C Motif Chemokine Ligand 10 2 3 5
  • Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 10 2 3
  • 10 KDa Interferon Gamma-Induced Protein 3 4
  • Chemokine (C-X-C Motif) Ligand 10 2 3
  • Small-Inducible Cytokine B10 3 4
  • SCYB10 3 4
  • INP10 3 4
  • IP-10 3 4
  • Protein 10 From Interferon (Gamma)-Induced Cell Line 3
  • Interferon-Inducible Cytokine IP-10 3
  • C-X-C Motif Chemokine 10 3
  • Gamma IP10 3
  • Gamma-IP10 4
  • GIP-10 3
  • IFI10 3
  • Crg-2 3
  • Mob-1 3
  • C7 3

External Ids for CXCL10 Gene

Previous HGNC Symbols for CXCL10 Gene

  • INP10
  • SCYB10

Previous GeneCards Identifiers for CXCL10 Gene

  • GC04M076838
  • GC04M077132
  • GC04M077335
  • GC04M077400
  • GC04M077299
  • GC04M076942
  • GC04M072694

Summaries for CXCL10 Gene

Entrez Gene Summary for CXCL10 Gene

  • This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014]

GeneCards Summary for CXCL10 Gene

CXCL10 (C-X-C Motif Chemokine Ligand 10) is a Protein Coding gene. Diseases associated with CXCL10 include Endotheliitis and Severe Acute Respiratory Syndrome. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include receptor binding and chemokine activity. An important paralog of this gene is CXCL9.

UniProtKB/Swiss-Prot for CXCL10 Gene

  • Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.

Gene Wiki entry for CXCL10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL10 Gene

Genomics for CXCL10 Gene

Regulatory Elements for CXCL10 Gene

Enhancers for CXCL10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F076042 0.5 FANTOM5 57.9 -18.9 -18899 0.2 POLR2H JUN JUNB FOS CXCL9 CXCL10 CXCL11 NAAA GC04P076101
GH04F076029 0.7 FANTOM5 36.9 -6.0 -5955 0.2 KLF1 ARID4B ZNF335 ZNF316 ZFHX2 ZNF366 MAFK EGR2 SP3 MAZ CXCL9 CXCL10 CXCL11 SDAD1 ART3 NAAA GC04M075923 RPL36P8
GH04F076059 1.7 FANTOM5 Ensembl ENCODE 32.8 -36.7 -36660 1.6 ATF1 NR2F1 ZNF175 ZNF384 ZBTB40 ZGPAT ZNF512 IKZF1 CREB1 SPI1 ART3 CXCL10 CXCL9 NAAA CXCL11 NUP54 SDAD1 LOC101928809 GC04P076101
GH04F075845 0.3 FANTOM5 27.5 +177.7 177694 0.2 CXCL10 CXCL9 CXCL11 NAAA GC04P075831 LOC105377285
GH04F076028 0.5 FANTOM5 23.8 -3.9 -3917 0.1 HDAC1 HDGF ATF1 KLF1 SIN3A ARID4B KLF17 GLIS2 ZFHX2 FOXK2 ART3 CXCL10 CXCL9 CXCL11 SDAD1 THAP6 NUP54 NAAA GC04M075923 RPL36P8
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CXCL10 on UCSC Golden Path with GeneCards custom track

Genomic Location for CXCL10 Gene

76,021,116 bp from pter
76,023,536 bp from pter
2,421 bases
Minus strand

Genomic View for CXCL10 Gene

Genes around CXCL10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCL10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL10 Gene

Proteins for CXCL10 Gene

  • Protein details for CXCL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-X-C motif chemokine 10
    Protein Accession:
    Secondary Accessions:
    • Q96QJ5

    Protein attributes for CXCL10 Gene

    98 amino acids
    Molecular mass:
    10881 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CXCL10 Gene

neXtProt entry for CXCL10 Gene

Post-translational modifications for CXCL10 Gene

  • CXCL10(1-73) is produced by proteolytic cleavage after secretion from keratinocytes.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CXCL10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CXCL10 (CXCL10/IP-10/CRG-2)
  • Cell Signaling Technology (CST) Antibodies for CXCL10 (CXCL10)
  • Cloud-Clone Corp. Antibodies for CXCL10
  • Santa Cruz Biotechnology (SCBT) Antibodies for CXCL10

No data available for DME Specific Peptides for CXCL10 Gene

Domains & Families for CXCL10 Gene

Gene Families for CXCL10 Gene

Suggested Antigen Peptide Sequences for CXCL10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intercrine alpha (chemokine CxC) family.
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL10: view

Function for CXCL10 Gene

Molecular function for CXCL10 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma. A diverse population of cell types rapidly increases transcription of mRNA encoding this protein. This suggests that gamma-induced protein may be a key mediator of the IFNG/IFN-gamma response.

Gene Ontology (GO) - Molecular Function for CXCL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 10201891
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 18275857
GO:0008009 chemokine activity IEA,IDA 12782716
GO:0008201 heparin binding IMP 18645041
genes like me logo Genes that share ontologies with CXCL10: view
genes like me logo Genes that share phenotypes with CXCL10: view

Animal Models for CXCL10 Gene

MGI Knock Outs for CXCL10:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CXCL10 Gene

Localization for CXCL10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL10 Gene


Subcellular locations from

Jensen Localization Image for CXCL10 Gene COMPARTMENTS Subcellular localization image for CXCL10 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 2
nucleus 2
cytoskeleton 1
endosome 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CXCL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA,IBA --
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with CXCL10: view

Pathways & Interactions for CXCL10 Gene

genes like me logo Genes that share pathways with CXCL10: view

Gene Ontology (GO) - Biological Process for CXCL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IDA 12782716
GO:0006952 defense response IEA --
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IEA,IBA --
GO:0007165 signal transduction TAS 10201891
genes like me logo Genes that share ontologies with CXCL10: view

No data available for SIGNOR curated interactions for CXCL10 Gene

Drugs & Compounds for CXCL10 Gene

(34) Drugs for CXCL10 Gene - From: DrugBank, PharmGKB, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Peginterferon alfa-2a Approved, Investigational Pharma 563
Peginterferon alfa-2b Approved Pharma 308
N-Methylleucine Experimental Pharma Target 0
MDX-1100 Pharma 0

(26) Additional Compounds for CXCL10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CXCL10: view

Transcripts for CXCL10 Gene

mRNA/cDNA for CXCL10 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(90) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CXCL10 Gene

Chemokine (C-X-C motif) ligand 10:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL10 Gene

No ASD Table

Relevant External Links for CXCL10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CXCL10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CXCL10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CXCL10 Gene

This gene is overexpressed in Brain - Substantia nigra (x10.4), Cervix - Ectocervix (x4.4), and Lung (x4.0).

Protein differential expression in normal tissues from HIPED for CXCL10 Gene

This gene is overexpressed in Ovary (60.4) and Placenta (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CXCL10 Gene

Protein tissue co-expression partners for CXCL10 Gene

NURSA nuclear receptor signaling pathways regulating expression of CXCL10 Gene:


SOURCE GeneReport for Unigene cluster for CXCL10 Gene:

genes like me logo Genes that share expression patterns with CXCL10: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CXCL10 Gene

Orthologs for CXCL10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CXCL10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CXCL10 34 35
  • 98.96 (n)
(Canis familiaris)
Mammalia CXCL10 34 35
  • 86.05 (n)
(Bos Taurus)
Mammalia CXCL10 34 35
  • 85.07 (n)
(Mus musculus)
Mammalia Cxcl10 34 16 35
  • 74.49 (n)
(Rattus norvegicus)
Mammalia Cxcl10 34
  • 74.15 (n)
(Monodelphis domestica)
Mammalia CXCL10 35
  • 44 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 36 (a)
Species where no ortholog for CXCL10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL10 Gene

Gene Tree for CXCL10 (if available)
Gene Tree for CXCL10 (if available)

Paralogs for CXCL10 Gene

Paralogs for CXCL10 Gene

(12) SIMAP similar genes for CXCL10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CXCL10: view

Variants for CXCL10 Gene

Sequence variations from dbSNP and Humsavar for CXCL10 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10014837 -- 76,020,665(+) CCTAT(A/G)GGATA intron-variant, downstream-variant-500B
rs112120686 -- 76,021,397(+) GAATA(C/T)TTACA intron-variant, utr-variant-3-prime
rs1126856 -- 76,023,417(-) ACTGC(C/G)ATTCT intron-variant, reference, synonymous-codon
rs1126858 -- 76,021,932(-) CTCCT(C/T)AAAAC intron-variant, reference, stop-lost
rs11298565 -- 76,022,612(+) TGATC(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CXCL10 Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER inversion 18451855

Variation tolerance for CXCL10 Gene

Residual Variation Intolerance Score: 77.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CXCL10 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL10 Gene

Disorders for CXCL10 Gene

MalaCards: The human disease database

(43) MalaCards diseases for CXCL10 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
severe acute respiratory syndrome
  • sars
  • mucocutaneous-lymphangitic paracoccidioidomycosis
avian influenza
  • avian flu
viral encephalitis
  • epidemic encephalitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CXCL10

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CXCL10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL10 Gene

Publications for CXCL10 Gene

  1. Genetic association between a chemokine gene CXCL-10 (IP-10, interferon gamma inducible protein 10) and susceptibility to tuberculosis. (PMID: 19523460) Tang N.L. … Chan C.Y. (Clin. Chim. Acta 2009) 3 22 46 64
  2. Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation. (PMID: 18645041) Loos T. … Proost P. (Blood 2008) 3 4 22 64
  3. The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions. (PMID: 12173928) Booth V. … Sykes B.D. (Biochemistry 2002) 3 4 22 64
  4. Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. (PMID: 3925348) Luster A.D. … Ravetch J.V. (Nature 1985) 2 3 4 64
  5. Candidate genes associated with susceptibility for SARS-coronavirus. (PMID: 19590927) Hsieh Y.H. … Ho M.S. (Bull. Math. Biol. 2010) 3 46 64

Products for CXCL10 Gene

Sources for CXCL10 Gene

Loading form....