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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CXCL10 Gene

protein-coding   GIFtS: 64
GCID: GC04M076942

Chemokine (C-X-C Motif) Ligand 10

(Previous names: small inducible cytokine subfamily B (Cys-X-Cys), member...)
(Previous symbols: INP10, SCYB10)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chemokine (C-X-C Motif) Ligand 101 2     C-X-C Motif Chemokine 102
INP101 2 3 5     crg-22
SCYB101 2 3     gIP-102
Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 101 2     Gamma IP102
Small-Inducible Cytokine B102 3     gamma-IP102
10 KDa Interferon Gamma-Induced Protein2 3     Interferon-Inducible Cytokine IP-102
IP-102 3     mob-12
C72     Protein 10 From Interferon (Gamma)-Induced Cell Line2
IFI102     Gamma-IP103

External Ids:    HGNC: 106371   Entrez Gene: 36272   Ensembl: ENSG000001692457   OMIM: 1473105   UniProtKB: P027783   

Export aliases for CXCL10 gene to outside databases

Previous GC identifers: GC04M076838 GC04M077132 GC04M077335 GC04M077400 GC04M077299 GC04M072694


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CXCL10 Gene:
This gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to
CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration,
and modulation of adhesion molecule expression. (provided by RefSeq, Jul 2008)

GeneCards Summary for CXCL10 Gene: 
CXCL10 (chemokine (C-X-C motif) ligand 10) is a protein-coding gene. Diseases associated with CXCL10 include paracoccidioidomycosis, and sydenham's chorea, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Immune response TLR signaling pathways. GO annotations related to this gene include cAMP-dependent protein kinase regulator activity and receptor binding. An important paralog of this gene is CXCL9.

UniProtKB/Swiss-Prot: CXL10_HUMAN, P02778
Function: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3

Gene Wiki entry for CXCL10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CXCL10 gene promoter:
         AML1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXCL10 promoter sequence
   Search SABiosciences Chromatin IP Primers for CXCL10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCL10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q21.1   HGNC cytogenetic band: 4q21

CXCL10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCL10 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M076942:  view genomic region     (about GC identifiers)

Start:
76,942,269 bp from pter      End:
76,944,689 bp from pter
Size:
2,421 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CXL10_HUMAN, P02778 (See protein sequence)
Recommended Name: C-X-C motif chemokine 10 precursor  
Size: 98 amino acids; 10881 Da
Subcellular location: Secreted
Mass spectrometry: Mass=8641.8; Method=Electrospray; Range=22-98; Source=PubMed:11559369;
4 PDB 3D structures from and Proteopedia for CXCL10:
1LV9 (3D)        1O7Y (3D)        1O7Z (3D)        1O80 (3D)    
Secondary accessions: Q96QJ5

Explore the universe of human proteins at neXtProt for CXCL10: NX_P02778

Explore proteomics data for CXCL10 at MOPED 

Post-translational modifications:

  • UniProtKB: CXCL10(1-73) is produced by proteolytic cleavage after secretion from keratinocytes
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P02778

  • CXCL10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CXCL10 Protein Expression
    REFSEQ proteins: NP_001556.2  
    ENSEMBL proteins: 
     ENSP00000305651  
    Reactome Protein details: P02778
    Human Recombinant Protein Products for CXCL10: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CXCL10 (CXCL10/IP-10/CRG-2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CXCL10
    OriGene Protein Over-expression Lysate for CXCL10
    OriGene MassSpec for CXCL10 
    OriGene Custom Protein Services for CXCL10
    GenScript Purified and Recombinant Proteins for CXCL10
    Novus Biologicals CXCL10 Proteins
    Novus Biologicals CXCL10 Lysates
    Sino Biological Recombinant Protein for CXCL10
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CXCL10
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0009897external side of plasma membrane IEA--

    CXCL10 for ontologies           About GeneDecksing



    CXCL10 Antibody Products: 
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    Novus Biologicals CXCL10 Antibodies
    Abcam antibodies for CXCL10
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for CXCL10
    LSBio Antibodies in human, mouse, rat for CXCL10 

    Assay Products for CXCL10: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CXCL10
    R&D Systems ELISAs for CXCL10 (CXCL10/IP-10/CRG-2)         (see all)
    GenScript Custom Assay Services for CXCL10
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands

    4 InterPro protein domains:
     IPR001811 Chemokine_IL8-like_dom
     IPR001089 Chemokine_CXC
     IPR027220 Chemokine_CXCL10
     IPR018048 Chemokine_CXC_CS

    Graphical View of Domain Structure for InterPro Entry P02778

    ProtoNet protein and cluster: P02778

    UniProtKB/Swiss-Prot: CXL10_HUMAN, P02778
    Similarity: Belongs to the intercrine alpha (chemokine CxC) family


    CXCL10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CXL10_HUMAN, P02778
    Function: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3
    Induction: By IFNG/IFN-gamma. A diverse population of cell types rapidly increases transcription of mRNA encoding
    this protein. This suggests that gamma-induced protein may be a key mediator of the IFNG/IFN-gamma response

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS10201891
    GO:0005515protein binding IPI18275857
    GO:0008009chemokine activity IEA--
    GO:0008603cAMP-dependent protein kinase regulator activity TAS10903763
         
    CXCL10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CXCL10:
     Synthetic lethal with c-Myc af 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cxcl10):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  nervous system 

    CXCL10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cxcl10tm1Adl for CXCL10

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CXCL10 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CXCL10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CXCL10 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CXCL10 

    miRNA
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    hsa-miR-15a hsa-miR-503 hsa-let-7a-2* hsa-miR-497 hsa-miR-570 hsa-miR-646 hsa-miR-424 hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidCXCL10 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CXCL10

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector: CXCL10 (NM_001565)
    Sino Biological Human cDNA Clone for CXCL10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL10
    Sirion Biotech Customized lentivirus for stable overexpression of CXCL10 
                         Customized lentivirus expression plasmids for stable overexpression of CXCL10 

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL10


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CXCL10 About   (see all 18)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    IL-6 Pathway0.61
    MIF Regulation of Innate Immune Cells0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43
    2Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response0.94
    Immune response TLR signaling pathways0.94
    3Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.93
    4Chemokine Signaling
    Chemokine Signaling0.33
    Chemokine signaling pathway0.33
    5Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CXCL10
        Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response

    5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CXCL10 (see all 17)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    MIF Mediated Glucocorticoid Regulation

    1 GeneGo (Thomson Reuters) Pathway for CXCL10
        Immune response TLR signaling pathways

    4 BioSystems Pathways for CXCL10
        Type II interferon signaling (IFNG)
    Spinal Cord Injury
    Toll-like receptor signaling pathway
    CXCR3-mediated signaling events


    5/8        Reactome Pathways for CXCL10 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    5/7         Kegg Pathways  (Kegg details for CXCL10) (see all 7):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Toll-like receptor signaling pathway
    RIG-I-like receptor signaling pathway
    Cytosolic DNA-sensing pathway


    CXCL10 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CXCL10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/160 Interacting proteins for CXCL10 (P027782, 3 ENSP000003056514) via UniProtKB, MINT, STRING, and/or I2D (see all 160)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DPP4P274872, 3, ENSP000003537314MINT-8091106 I2D: score=2 STRING: ENSP00000353731
    IGFBP7Q162703, ENSP000002956664I2D: score=3 STRING: ENSP00000295666
    VCANP136113, ENSP000002650774I2D: score=3 STRING: ENSP00000265077
    CCR3P516773, ENSP000003500034I2D: score=1 STRING: ENSP00000350003
    CXCR3P496823, ENSP000003627954I2D: score=4 STRING: ENSP00000362795
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002690positive regulation of leukocyte chemotaxis IEA--
    GO:0006935chemotaxis IEA--
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0007165signal transduction TAS10201891

    CXCL10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CXCL10 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CXCL10 (CXL10)

    1 DrugBank Compound for CXCL10    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    N-Methylleucine-- --target--17139284 17016423

    10/56 Novoseek inferred chemical compound relationships for CXCL10 gene (see all 56)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 89.4 190 15949333 (4), 11390609 (4), 18385799 (4), 9426952 (4) (see all 99)
    ccl3 86.2 51 15480163 (4), 19906920 (2), 12960247 (2), 20205697 (2) (see all 36)
    groalpha 76.7 8 15975968 (2), 11163401 (1), 15972545 (1), 9846975 (1) (see all 7)
    tarc 75.8 19 12441140 (3), 11310827 (3), 15927812 (3), 15488706 (1) (see all 11)
    ccl4 68.5 34 12960247 (2), 12538673 (2), 11178128 (1), 14734774 (1) (see all 28)
    ifn-alpha 53.9 5 18240301 (3), 17114181 (1), 16571725 (1)
    polyinosinic-polycytidylic acid 53.5 4 16265667 (1), 16966508 (1), 18941247 (1), 20231782 (1)
    poly(i-c) 52 5 16265667 (1), 16423036 (1), 9858321 (1), 16142732 (1)
    2',5'-oligoadenylate 48.7 4 17428863 (1), 16423036 (1), 15320959 (1)
    vegf 45.7 46 18385799 (6), 11890674 (4), 19700197 (3), 19549024 (2) (see all 27)

    Search CenterWatch for drugs/clinical trials and news about CXCL10 / CXL10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CXCL10 gene: 
    NM_001565.3  

    Unigene Cluster for CXCL10:

    Chemokine (C-X-C motif) ligand 10
    Hs.632586  [show with all ESTs]
    Unigene Representative Sequence: NM_001565
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000306602(uc003hjl.4)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL10 (see all 12):
    hsa-miR-15a hsa-miR-503 hsa-let-7a-2* hsa-miR-497 hsa-miR-570 hsa-miR-646 hsa-miR-424 hsa-let-7g*
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    Sirion Biotech Customized lentivirus for stable overexpression of CXCL10 
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL10

    Additional mRNA sequence: 

    BC010954.1 X02530.1 

    3 DOTS entries:

    DT.114294  DT.121232720  DT.95156805 

    24/90 AceView cDNA sequences (see all 90):

    BF059730 AI924176 AA301023 AI241171 AI681282 BF056337 AA361697 CB995581 
    BC010954 AI270680 AW057871 AA164919 AA301018 AW473007 X02530 AI432694 
    AA741432 AI338979 CB956704 CB984591 BM831012 BM768863 AW473011 AI683351 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CXCL10 expression in normal human tissues (normalized intensities)      CXCL10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACATAAGA
    CXCL10 Expression
    About this image


    CXCL10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 3 entries
             Body Subcutaneous White Adipose
             Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Thymus (Hematopoietic System)
             Thymus
     
     Blood Brain Barrier (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain

    See CXCL10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CXCL10

    SOURCE GeneReport for Unigene cluster: Hs.632586
        SABiosciences Expression via Pathway-Focused PCR Arrays including CXCL10 (see all 18): 
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Interferons & Receptors in human mouse rat
              Chemokines & Receptors in human mouse rat
              Nephrotoxicity in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for CXCL10 gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cxcl101 , 5 chemokine (C-X-C motif) ligand 101, 5 74.49(n)1
    68.37(a)1
      5 (46.57 cM)5
    159451  NM_021274.21  NP_067249.11 
     923466385 


    ENSEMBL Gene Tree for CXCL10 (if available)
    TreeFam Gene Tree for CXCL10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CXCL10 gene
    CXCL92  
    12 SIMAP similar genes for CXCL10 using alignment to 1 protein entry:     CXL10_HUMAN:
    PF4    PF4V1    CXCL2    CXCL6    CXCL9    CXCL1
    CXCL3    CXCL12    CXCL13    CXCL5    CXCL11    IL8

    CXCL10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CXCL10:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv7363OTHER Inversion18451855


    Human Gene Mutation Database (HGMD): CXCL10
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CXCL10
    DNA2.0 Custom Variant and Variant Library Synthesis for CXCL10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 147310    OMIM disorders: --

    20/167 diseases for CXCL10 (see all 167):    About MalaCards
    paracoccidioidomycosis    sydenham's chorea    peritoneal carcinoma    severe acute respiratory syndrome
    yellow fever    primary peritoneal carcinoma    nodular goiter    cystoid macular edema
    viral encephalitis    cluttering    newcastle disease    japanese encephalitis
    cryptosporidiosis    legionnaires' disease    corneal neovascularization    invasive aspergillosis
    mixed cryoglobulinemia    biliary atresia    proliferative diabetic retinopathy    intracranial hypertension

    11 diseases from the University of Copenhagen DISEASES database for CXCL10:
    Multiple sclerosis     Tuberculosis     Hypersensitivity reaction type II disease     Encephalitis
    Asthma     Severe acute respiratory syndrome     Influenza     Hepatitis C
    Pneumonia     Dermatitis     Arthritis

    CXCL10 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/95 Novoseek inferred disease relationships for CXCL10 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 68.3 43 15108349 (4), 19195322 (3), 9164978 (1), 17475924 (1) (see all 29)
    necrosis 65.9 105 18973545 (5), 8798675 (1), 9022006 (1), 9164978 (1) (see all 85)
    multiple sclerosis 48.4 12 19225413 (2), 11282170 (2), 16519660 (1), 14760949 (1) (see all 8)
    virus infection 47.8 23 11431017 (2), 14760949 (2), 17287085 (2), 12663757 (1) (see all 18)
    meningitis viral 47.2 1 9626995 (1)
    tumors 46.5 141 11265771 (6), 18973545 (5), 9064358 (4), 15194051 (3) (see all 92)
    hepatitis c chronic 45.4 13 12794718 (3), 11467655 (2), 20186843 (2), 19918044 (1) (see all 8)
    psoriasis 44.9 6 11344355 (2), 9625525 (1), 15149518 (1), 9705166 (1) (see all 5)
    autoimmune diseases 38.2 8 17475924 (2), 14607926 (1), 15531503 (1), 8301141 (1) (see all 7)
    hepatitis c 35.6 21 18760981 (4), 17389454 (2), 18775023 (2), 19195322 (2) (see all 8)

    Genetic Association Database (GAD): CXCL10
    Human Genome Epidemiology (HuGE) Navigator: CXCL10 (17 documents)

    Export disorders for CXCL10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CXCL10 gene, integrated from 9 sources (see all 1006):
    (articles sorted by number of sources associating them with CXCL10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. (PubMed id 3925348)1, 2, 3 Luster A.D....Ravetch J.V. (1985)
    2. Genetic association between a chemokine gene CXCL-10 (IP-10, interferon gamma inducible protein 10) and susceptibility to tuberculos is. (PubMed id 19523460)1, 4, 9 Tang N.L....Chan C.Y. (2009)
    3. Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation. (PubMed id 18645041)1, 2, 9 Loos T.... Proost P. (2008)
    4. The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions. (PubMed id 12173928)1, 2, 9 Booth V.... Sykes B.D. (2002)
    5. Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8. (PubMed id 8423327)1, 2, 9 Proost P....van Damme J. (1993)
    6. A CXC motif ligand 10 polymorphism as a marker to pre dict severity of Graves' disease. (PubMed id 20187787)1, 4 BrA1ck P....Ramos-Lopez E. (2010)
    7. Common polymorphisms in ITGA2, PON1 and THBS2 are ass ociated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (2010)
    8. Candidate genes associated with susceptibility for SA RS-coronavirus. (PubMed id 19590927)1, 4 Hsieh Y.H....Ho M.S. (2010)
    9. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)
    10. Association of cytokine and chemokine gene polymorphi sms with severe acute respiratory syndrome. (PubMed id 19258635)1, 4 Lau Y.L. and Peiris J.S. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3627 HGNC: 10637 AceView: CXCL10 Ensembl:ENSG00000169245 euGenes: HUgn3627
    ECgene: CXCL10 Kegg: 3627 H-InvDB: CXCL10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CXCL10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CXCL10 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CXCL10

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CXCL10 gene:
    Search GeneIP for patents involving CXCL10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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