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Aliases for CXCL10 Gene

Aliases for CXCL10 Gene

  • Chemokine (C-X-C Motif) Ligand 10 2 3
  • Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 10 2 3
  • 10 KDa Interferon Gamma-Induced Protein 3 4
  • Small-Inducible Cytokine B10 3 4
  • Gamma-IP10 3 4
  • SCYB10 3 4
  • INP10 3 4
  • IP-10 3 4
  • Protein 10 From Interferon (Gamma)-Induced Cell Line 3
  • Interferon-Inducible Cytokine IP-10 3
  • Gamma IP10 3
  • GIP-10 3
  • IFI10 3
  • Crg-2 3
  • Mob-1 3
  • C7 3

External Ids for CXCL10 Gene

Previous HGNC Symbols for CXCL10 Gene

  • INP10
  • SCYB10

Previous GeneCards Identifiers for CXCL10 Gene

  • GC04M076838
  • GC04M077132
  • GC04M077335
  • GC04M077400
  • GC04M077299
  • GC04M076942
  • GC04M072694

Summaries for CXCL10 Gene

Entrez Gene Summary for CXCL10 Gene

  • This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014]

GeneCards Summary for CXCL10 Gene

CXCL10 (Chemokine (C-X-C Motif) Ligand 10) is a Protein Coding gene. Diseases associated with CXCL10 include endotheliitis and severe acute respiratory syndrome. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include receptor binding and chemokine activity. An important paralog of this gene is CXCL9.

UniProtKB/Swiss-Prot for CXCL10 Gene

  • Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3

Gene Wiki entry for CXCL10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL10 Gene

Genomics for CXCL10 Gene

Regulatory Elements for CXCL10 Gene

Transcription factor binding sites by QIAGEN in the CXCL10 gene promoter:

Genomic Location for CXCL10 Gene

76,021,116 bp from pter
76,023,536 bp from pter
2,421 bases
Minus strand

Genomic View for CXCL10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CXCL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL10 Gene

Proteins for CXCL10 Gene

  • Protein details for CXCL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-X-C motif chemokine 10
    Protein Accession:
    Secondary Accessions:
    • Q96QJ5

    Protein attributes for CXCL10 Gene

    98 amino acids
    Molecular mass:
    10881 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CXCL10 Gene

neXtProt entry for CXCL10 Gene

Proteomics data for CXCL10 Gene at MOPED

Post-translational modifications for CXCL10 Gene

  • CXCL10(1-73) is produced by proteolytic cleavage after secretion from keratinocytes
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CXCL10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CXCL10 (CXCL10/IP-10/CRG-2)
  • Cell Signaling Technology (CST) Antibodies for CXCL10 (CXCL10)

No data available for DME Specific Peptides for CXCL10 Gene

Domains & Families for CXCL10 Gene

Gene Families for CXCL10 Gene

Protein Domains for CXCL10 Gene

Suggested Antigen Peptide Sequences for CXCL10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intercrine alpha (chemokine CxC) family.
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL10: view

Function for CXCL10 Gene

Molecular function for CXCL10 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma. A diverse population of cell types rapidly increases transcription of mRNA encoding this protein. This suggests that gamma-induced protein may be a key mediator of the IFNG/IFN-gamma response

Gene Ontology (GO) - Molecular Function for CXCL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 10201891
GO:0005515 protein binding IPI 18275857
GO:0008009 chemokine activity IDA 12782716
GO:0008201 heparin binding IMP 18645041
GO:0008603 cAMP-dependent protein kinase regulator activity TAS 10903763
genes like me logo Genes that share ontologies with CXCL10: view
genes like me logo Genes that share phenotypes with CXCL10: view

Animal Models for CXCL10 Gene

MGI Knock Outs for CXCL10:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CXCL10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CXCL10 Gene

Localization for CXCL10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL10 Gene


Subcellular locations from

Jensen Localization Image for CXCL10 Gene COMPARTMENTS Subcellular localization image for CXCL10 gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
plasma membrane 2
cytoskeleton 1
endosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CXCL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with CXCL10: view

Pathways & Interactions for CXCL10 Gene

genes like me logo Genes that share pathways with CXCL10: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CXCL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002690 positive regulation of leukocyte chemotaxis --
GO:0006935 chemotaxis IDA 12782716
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IBA --
GO:0007165 signal transduction TAS 10201891
genes like me logo Genes that share ontologies with CXCL10: view

No data available for SIGNOR curated interactions for CXCL10 Gene

Drugs & Compounds for CXCL10 Gene

(31) Drugs for CXCL10 Gene - From: NovoSeek, DGIdb, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
chloroquine Approved Pharma Agonist 137
Dexamethasone Approved, Investigational Pharma Agonist 1806
Fluticasone propionate Approved Pharma Selective high affinity glucocorticoid receptor agonist 0
Hydrocortisone Approved Pharma Agonist 550
Infliximab Approved Pharma 327

(27) Additional Compounds for CXCL10 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1-Methylglycocyamidine
  • 1-Methylhydantoin-2-imide
  • 2-Amino-1-methyl-1,5-dihydroimidazol-4-one
  • 2-Amino-1-methylimidazolin-4-one
  • Creatine anhydride
genes like me logo Genes that share compounds with CXCL10: view

Transcripts for CXCL10 Gene

mRNA/cDNA for CXCL10 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(90) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CXCL10 Gene

Chemokine (C-X-C motif) ligand 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CXCL10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL10 Gene

No ASD Table

Relevant External Links for CXCL10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CXCL10 Gene

mRNA expression in normal human tissues for CXCL10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CXCL10 Gene

This gene is overexpressed in Brain - Substantia nigra (x10.4), Cervix - Ectocervix (x4.4), and Lung (x4.0).

Protein differential expression in normal tissues from HIPED for CXCL10 Gene

This gene is overexpressed in Ovary (60.4) and Placenta (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CXCL10 Gene

SOURCE GeneReport for Unigene cluster for CXCL10 Gene Hs.632586

genes like me logo Genes that share expression patterns with CXCL10: view

Protein tissue co-expression partners for CXCL10 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CXCL10 Gene

Orthologs for CXCL10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CXCL10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CXCL10 35
  • 85.07 (n)
  • 79.17 (a)
CXCL10 36
  • 75 (a)
(Canis familiaris)
Mammalia CXCL10 35
  • 86.05 (n)
  • 77.55 (a)
CXCL10 36
  • 78 (a)
(Mus musculus)
Mammalia Cxcl10 35
  • 74.49 (n)
  • 68.37 (a)
Cxcl10 16
Cxcl10 36
  • 68 (a)
(Pan troglodytes)
Mammalia CXCL10 35
  • 98.96 (n)
  • 100 (a)
CXCL10 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cxcl10 35
  • 74.15 (n)
  • 67.35 (a)
(Monodelphis domestica)
Mammalia CXCL10 36
  • 44 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 36 (a)
Species with no ortholog for CXCL10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL10 Gene

Gene Tree for CXCL10 (if available)
Gene Tree for CXCL10 (if available)

Paralogs for CXCL10 Gene

Paralogs for CXCL10 Gene

(12) SIMAP similar genes for CXCL10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CXCL10: view

Variants for CXCL10 Gene

Structural Variations from Database of Genomic Variants (DGV) for CXCL10 Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER Inversion 18451855

Variation tolerance for CXCL10 Gene

Residual Variation Intolerance Score: 77.83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CXCL10 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for CXCL10 Gene

Disorders for CXCL10 Gene

MalaCards: The human disease database

(36) MalaCards diseases for CXCL10 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
severe acute respiratory syndrome
  • sars
sydenham's chorea
  • dystonia 21
  • lobomycosis
avian influenza
  • bird flu
- elite association

Relevant External Links for CXCL10

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CXCL10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL10 Gene

Publications for CXCL10 Gene

  1. CXCL10 production by human monocytes in response to Leishmania braziliensis infection. (PMID: 19901067) Vargas-Inchaustegui D.A. … Soong L. (Infect. Immun. 2010) 23 67
  2. Cellular immune responses to severe acute respiratory syndrome coronavirus (SARS-CoV) infection in senescent BALB/c mice: CD4+ T cells are important in control of SARS-CoV infection. (PMID: 19906920) Chen J. … Subbarao K. (J. Virol. 2010) 23 67
  3. Hepatitis B virus protein X-induced expression of the CXC chemokine IP-10 is mediated through activation of NF-kappaB and increases migration of leukocytes. (PMID: 20164184) Zhou Y. … Huang B. (J. Biol. Chem. 2010) 23 67
  4. Cerebrospinal fluid in HIV-1 systemic viral controllers: absence of HIV-1 RNA and intrathecal inflammation. (PMID: 20299968) Probasco J.C. … Spudich S.S. (AIDS 2010) 23 67
  5. Serum IP-10 as a biomarker of human rhinovirus infection at exacerbation of COPD. (PMID: 19837822) Quint J.K. … Wedzicha J.A. (Chest 2010) 23 67

Products for CXCL10 Gene

Sources for CXCL10 Gene

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