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Aliases for CXCL1 Gene

Aliases for CXCL1 Gene

  • Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha) 2 3
  • GRO1 Oncogene (Melanoma Growth Stimulating Activity, Alpha) 2 3
  • Neutrophil-Activating Protein 3 3 4
  • Fibroblast Secretory Protein 2 3
  • C-X-C Motif Chemokine 1 3 4
  • GRO-Alpha(1-73) 3 4
  • NAP-3 3 4
  • SCYB1 3 4
  • GROa 3 4
  • GRO1 3 4
  • MGSA 3 4
  • GRO1 Oncogene (Melanoma Growth-Stimulating Activity) 3
  • Melanoma Growth Stimulatory Activity Alpha 3
  • Melanoma Growth Stimulating Activity 6
  • Melanoma Growth Stimulatory Activity 4
  • Growth-Regulated Alpha Protein 3
  • MGSA Alpha 3
  • MGSA-A 3
  • Alpha) 6
  • FSP 3
  • GRO 4

External Ids for CXCL1 Gene

Previous Symbols for CXCL1 Gene

  • MGSA
  • GRO1
  • FSP

Summaries for CXCL1 Gene

Entrez Gene Summary for CXCL1 Gene

  • This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014]

GeneCards Summary for CXCL1 Gene

CXCL1 (Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha)) is a Protein Coding gene. Diseases associated with CXCL1 include melanoma and chronic granulomatous disease. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include receptor binding and chemokine activity. An important paralog of this gene is PF4.

UniProtKB/Swiss-Prot for CXCL1 Gene

  • Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.

Gene Wiki entry for CXCL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL1 Gene

Genomics for CXCL1 Gene

Genomic Location for CXCL1 Gene

Start:
73,869,392 bp from pter
End:
73,871,302 bp from pter
Size:
1,911 bases
Orientation:
Plus strand

Genomic View for CXCL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CXCL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL1 Gene

Regulatory Elements for CXCL1 Gene

Proteins for CXCL1 Gene

  • Protein details for CXCL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09341-GROA_HUMAN
    Recommended name:
    Growth-regulated alpha protein
    Protein Accession:
    P09341
    Secondary Accessions:
    • Q9UCR7

    Protein attributes for CXCL1 Gene

    Size:
    107 amino acids
    Molecular mass:
    11301 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CXCL1 Gene

neXtProt entry for CXCL1 Gene

Proteomics data for CXCL1 Gene at MOPED

Post-translational modifications for CXCL1 Gene

  • N-terminal processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.

Other Protein References for CXCL1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CXCL1 Gene

Domains for CXCL1 Gene

Gene Families for CXCL1 Gene

HGNC:

Protein Domains for CXCL1 Gene

UniProtKB/Swiss-Prot:

GROA_HUMAN
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.:
    • P09341
genes like me logo Genes that share domains with CXCL1: view

Function for CXCL1 Gene

Molecular function for CXCL1 Gene

UniProtKB/Swiss-Prot Function: Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.

Gene Ontology (GO) - Molecular Function for CXCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 10820279
GO:0008009 chemokine activity IEA --
GO:0008047 enzyme activator activity TAS 9079638
GO:0008083 growth factor activity IEA --
GO:0045236 CXCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with CXCL1: view

Phenotypes for CXCL1 Gene

MGI mutant phenotypes for CXCL1:
inferred from 1 alleles
GenomeRNAi human phenotypes for CXCL1:
genes like me logo Genes that share phenotypes with CXCL1: view

Animal Models for CXCL1 Gene

MGI Knock Outs for CXCL1:

miRNA for CXCL1 Gene

miRTarBase miRNAs that target CXCL1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CXCL1 Gene

Localization for CXCL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CXCL1 Gene COMPARTMENTS Subcellular localization image for CXCL1 gene
Compartment Confidence
extracellular 5
nucleus 2
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CXCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CXCL1: view

Pathways for CXCL1 Gene

genes like me logo Genes that share pathways with CXCL1: view

Gene Ontology (GO) - Biological Process for CXCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002690 positive regulation of leukocyte chemotaxis IBA --
GO:0006935 chemotaxis TAS 10820279
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IBA --
GO:0007165 signal transduction TAS 10820279
genes like me logo Genes that share ontologies with CXCL1: view

Compounds for CXCL1 Gene

(46) Novoseek inferred chemical compound relationships for CXCL1 Gene

Compound -log(P) Hits PubMed IDs
groalpha 97.3 195
grogamma 92.2 11
rantes 87.6 124
grobeta 87.4 13
ppbp 72.9 3
genes like me logo Genes that share compounds with CXCL1: view

Transcripts for CXCL1 Gene

mRNA/cDNA for CXCL1 Gene

Unigene Clusters for CXCL1 Gene

Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL1 Gene

No ASD Table

Relevant External Links for CXCL1 Gene

GeneLoc Exon Structure for
CXCL1
ECgene alternative splicing isoforms for
CXCL1

Expression for CXCL1 Gene

mRNA expression in normal human tissues for CXCL1 Gene

mRNA differential expression in normal tissues according to GTEx for CXCL1 Gene

This gene is overexpressed in Spleen (12.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CXCL1 Gene

SOURCE GeneReport for Unigene cluster for CXCL1 Gene Hs.789

genes like me logo Genes that share expressions with CXCL1: view

Orthologs for CXCL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXCL1 36
  • 98.75 (n)
  • 100 (a)
CXCL1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 81 (a)
ManyToMany
CXCL3 37
  • 78 (a)
ManyToMany
GRO1 37
  • 50 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cxcl1 16
Cxcl1 37
  • 60 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 41 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 58 (a)
ManyToMany
-- 37
  • 53 (a)
ManyToMany
-- 37
  • 52 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 37
  • 40 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 38 (a)
OneToMany
Species with no ortholog for CXCL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL1 Gene

ENSEMBL:
Gene Tree for CXCL1 (if available)
TreeFam:
Gene Tree for CXCL1 (if available)

Paralogs for CXCL1 Gene

Paralogs for CXCL1 Gene

Selected SIMAP similar genes for CXCL1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CXCL1 Gene

genes like me logo Genes that share paralogs with CXCL1: view

Variants for CXCL1 Gene

Sequence variations from dbSNP and Humsavar for CXCL1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs4074 -- 73,870,427(+) TCGGA(A/G)AACTC intron-variant
rs930113 -- 73,870,184(+) CCTGG(A/C)GTCCC intron-variant
rs1814092 -- 73,870,518(+) CATTG(C/T)AGTGA intron-variant
rs1957068 -- 73,871,188(+) AGGGG(C/T)TTAAT utr-variant-3-prime, nc-transcript-variant
rs2018732 -- 73,870,017(+) ACAGG(C/G/T)GACTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CXCL1 Gene

Variant ID Type Subtype PubMed ID
nsv525980 CNV Gain 19592680

Relevant External Links for CXCL1 Gene

HapMap Linkage Disequilibrium report
CXCL1

Disorders for CXCL1 Gene

(2) University of Copenhagen DISEASES for CXCL1 Gene

(58) Novoseek inferred disease relationships for CXCL1 Gene

Disease -log(P) Hits PubMed IDs
inflammation 65.4 23
necrosis 58.3 33
melanoma 50.4 35
nasal polyps 47.3 7
tumors 44.1 56

Relevant External Links for CXCL1

Genetic Association Database (GAD)
CXCL1
Human Genome Epidemiology (HuGE) Navigator
CXCL1
genes like me logo Genes that share disorders with CXCL1: view

No data available for UniProtKB/Swiss-Prot for CXCL1 Gene

Publications for CXCL1 Gene

  1. Lipopolysaccharide-stimulated human monocytes secrete, apart from neutrophil-activating peptide 1/interleukin 8, a second neutrophil- activating protein. NH2-terminal amino acid sequence identity with melanoma growth stimulatory activity. (PMID: 2182761) Schroeder J.-M. … Christophers E. (J. Exp. Med. 1990) 3 4 23
  2. Identification of three related human GRO genes encoding cytokine functions. (PMID: 2217207) Haskill S. … Sager R. (Proc. Natl. Acad. Sci. U.S.A. 1990) 2 3 23
  3. Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms. (PMID: 10095777) Wuyts A. … Van Damme J. (Eur. J. Biochem. 1999) 3 4 23
  4. Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population. (PMID: 15843053) Tamura Y. … Hohjoh H. (Neurosci. Lett. 2005) 3 23 49
  5. Growth-regulated oncogene-1 expression is associated with angiogenesis and lymph node metastasis in human oral cancer. (PMID: 15218300) Shintani S. … Hamakawa H. (Oncology 2004) 3 23

Products for CXCL1 Gene

Sources for CXCL1 Gene

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