CXCL1 Gene

Aliases
for CXCL1 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC04P074974 GC04P075135 GC04P075201 GC04P075100 GC04P070546

Summaries
for CXCL1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for CXCL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000004.11  NC_018915.2  NT_016354.20  

SwitchGear Promoter luciferase reporter plasmid: CXCL1 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CXCL1

CXCL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P074724:  view genomic region     (about GC identifiers)

Proteins
for CXCL1 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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4 PDB 3D structures from and Proteopedia for CXCL1:

1MGS (3D)        1MSG (3D)        1MSH (3D)        1ROD (3D)    

Explore the universe of human proteins at neXtProt for CXCL1: NX_P09341

Explore proteomics data for CXCL1 at MOPED

Post-translational modifications: 

CXCL1 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CXCL1 (CXCL1/GRO alpha/KC/CINC-1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for CXCL1 OriGene Custom MassSpec OriGene Custom Protein Services for CXCL1
	GenScript Purified and Recombinant Proteins for CXCL1
	Novus Biologicals CXCL1 Proteins Novus Biologicals CXCL1 Lysates
	Sino Biological Recombinant Protein for CXCL1 Browse Sino Biological Cell Lysates
	ProSpec Recombinant Protein for CXCL1
	Browse Proteins at Cloud-Clone Corp.
	eBioscience Proteins for CXCL1:                       Human CXCL1 (GRO alpha) Recombinant Protein Carrier-Free (To Be Discontinued) 100 ug
	GeneTex Proteins for CXCL1: (see all 3)                      KC Recombinant Protein (Active) (GTX48313-PRO)
	antibodies-online proteins for CXCL1 (105 products)
	antibodies-online peptides for CXCL1

CXCL1 Antibody Products:

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	R&D Systems Antibodies for CXCL1 (CXCL1/GRO alpha/KC/CINC-1)
	OriGene Antibodies for CXCL1 OriGene Custom Antibody Services for CXCL1
	Novus Biologicals CXCL1 Antibodies
	Abcam antibodies for CXCL1
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibodies for CXCL1
	antibodies-online antibodies for CXCL1 (100 products)

CXCL1 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for CXCL1
	R&D Systems ELISAs for CXCL1 (CXCL1/GRO alpha/KC/CINC-1)         (see all)
	GenScript Custom Assay Services for CXCL1
	Enzo Life Sciences assays for CXCL1
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.
	Search eBioscience for ELISAs for CXCL1
	antibodies-online kits for CXCL1 (91 products)

Domains /
Families
for CXCL1 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: P09341

Find genes that share domains with CXCL1           About GenesLikeMe

Function
for CXCL1 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

     Gene Ontology (GO): 4 molecular function terms:    About this table

(inferred from 1 allele) (MGI details for Cxcl1)

genOway: Develop your customized and physiologically relevant rodent model for CXCL1

miRNA Products:		miRTarBase miRNAs that target CXCL1: hsa-mir-1 (MIRT023999), hsa-mir-124-3p (MIRT023084)
		Block miRNA regulation of human, mouse, rat CXCL1 using miScript Target Protectors
		7 qRT-PCR Assays for microRNAs that regulate CXCL1:
		hsa-miR-3163 hsa-miR-607 hsa-miR-873 hsa-miR-641 hsa-miR-539 hsa-miR-3662 hsa-miR-3617
		SwitchGear 3'UTR luciferase reporter plasmid: CXCL1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CXCL1
		Predesigned siRNA for gene silencing in human, mouse, rat CXCL1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CXCL1

Clone Products:		OriGene clones in human, mouse for CXCL1 (see all 7) OriGene ORF clones in mouse, rat for CXCL1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CXCL1 (NM_001511)
		Sino Biological Human cDNA Clone for CXCL1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CXCL1
		Browse ESI BIO Cell Lines and PureStem Progenitors for CXCL1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL1

Localization
for CXCL1 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
extracellular	5
nucleus	2
cytoskeleton	1
plasma membrane	1

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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for CXCL1 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for CXCL1 About   (see all 21)   See pathways by source

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	SuperPath	Selected contained pathways About (see all per SuperPath)
1	PEDF Induced Signaling	MIF Regulation of Innate Immune Cells 0.94 IL-6 Pathway 0.61 MIF Mediated Glucocorticoid Regulation 0.94 STAT3 Pathway 0.47 PEDF Induced Signaling 0.73 Endothelin-1 Signaling Pathway 0.46 all-trans-Retinoic Acid Signaling in Brain 0.71 Cytokine-cytokine receptor interaction 0.43
2	Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions	Chemokine receptors bind chemokines 0.81 Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions 0.81
3	Chemokine Signaling	Chemokine Signaling 0.33 Chemokine signaling pathway 0.33
4	Peptide ligand-binding receptors	Class A/1 (Rhodopsin-like receptors) 0.71 Peptide ligand-binding receptors 0.60 GPCR ligand binding 0.71 G alpha (i) signalling events 0.44
5	Signaling by GPCR	Signaling by GPCR 0.90 Signal Transduction 0.58 GPCR downstream signaling 0.90

1 R&D Systems Pathway for CXCL1

Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CXCL1

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	Transendothelial Migration of Leukocytes
	MIF Mediated Glucocorticoid Regulation

2 GeneGo (Thomson Reuters) Pathways for CXCL1

	Cytokine production by Th17 cells in CF (Mouse model)
	Cytokine production by Th17 cells in CF

4 BioSystems Pathways for CXCL1

	Cytokines and Inflammatory Response
	Senescence and Autophagy
	Spinal Cord Injury
	IL23-mediated signaling events

2 Reactome Pathways for CXCL1

	Chemokine receptors bind chemokines
	G alpha (i) signalling events

Selected Kegg Pathways  (Kegg details for CXCL1)

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway
	NOD-like receptor signaling pathway
	TNF signaling pathway
	Epithelial cell signaling in Helicobacter pylori infection

Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

Drugs & Compounds
for CXCL1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for CXCL1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for CXCL1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CXCL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTGAAACTTT

About this image

Mesenchymal Stem Cells
Placenta-derived mesenchymal stem cells (family)
Blood (Cardiovascular System)    fully expand to see all 3 entries
Monocytes Peripheral Blood
Bone (Muscoskeletal System)    fully expand to see all 2 entries
Bone marrow-derived mesenchymal stem cells
Adipose (Muscoskeletal System)    fully expand to see all 2 entries
Body Subcutaneous White Adipose
Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
Placenta-derived mesenchymal stem cells (family)

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for CXCL1
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CXCL1
		QuantiTect SYBR Green Assays in human, mouse, rat CXCL1
		QuantiFast Probe-based Assays in human, mouse, rat CXCL1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL1

Orthologs
for CXCL1 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for CXCL1 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for CXCL1 gene

PPBP²  PF4²  PF4V1²  CXCL6²  CXCL3²  CXCL5²  CXCL2²  IL8²  

13 SIMAP similar genes for CXCL1 using alignment to 1 protein entry:     GROA_HUMAN:

MGSA alpha    CXCL3    CXCL2    PPBP    CXCL5    CXCL6

CXCL9    PF4    PF4V1    CXCL10    IL8    CXCL11

CXCL12

Find genes that share paralogs with CXCL1           About GenesLikeMe


1 Pseudogenes.org Pseudogene for CXCL1
PGOHUM00000245590

Genomic Variants
for CXCL1 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CXCL1 (see all 177)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1824091421,2		--	74733122(+)	AGAAAC/TAATTG	2	--	us2k1		0	--	--	--	--
rs1869144671,2		--	74733165(+)	GTCTGC/TTTTAA	2	--	us2k1		0	--	--	--	--
rs785726271,2	F	--	74733296(+)	ATTCTG/ATCTTC	2	--	us2k1		1		WA	118
rs738288961,2	C	--	74733345(+)	TATATG/AGTGTT	2	--	us2k1		2		WA	120
rs1924422481,2	C	--	74733351(+)	GTGTTA/GTATAC	2	--	us2k1		0	--	--	--	--
rs1850932331,2		--	74733454(+)	ATATAA/TATATA	2	--	us2k1		0	--	--	--	--
rs49929781,2	C	--	74733474(+)	ATATAT/AATATA	2	--	us2k1 tfbs3		1		NA	2
rs68252951,2	C	--	74733482(+)	atataA/Tatata	2	--	us2k1 tfbs3		0	--	--	--	--
rs285761701,2	C	--	74733482(+)	ATATAT/AATATA	2	--	us2k1 tfbs3		1		WA	2
rs285305141,2	C	--	74733555(+)	TTTTTA/TTTAAA	2	--	us2k1 trp3		1		CSA	1

HapMap Linkage Disequilibrium report for CXCL1 (74735109 - 74736959 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for CXCL1:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv525980	CNV	Gain	19592680

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing CXCL1

DNA2.0 Custom Variant and Variant Library Synthesis for CXCL1

Disorders / Diseases
for CXCL1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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2 diseases for CXCL1

Selected Novoseek inferred disease relationships for CXCL1 gene (see all 58)    About this table

Publications
for CXCL1 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population. (PubMed id 15843053)^{1, 4, 9} Tamura Y....Hohjoh H. (Neurosci. Lett. 2005)
2. Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms. (PubMed id 10095777)^{1, 2, 9} Wuyts A.... Van Damme J. (Eur. J. Biochem. 1999)
3. Identification of three related human GRO genes encoding cytokine functions. (PubMed id 2217207)^{1, 3, 9} Haskill S.... Sager R. (Proc. Natl. Acad. Sci. U.S.A. 1990)
4. Lipopolysaccharide-stimulated human monocytes secrete, apart from neutrophil-activating peptide 1/interleukin 8, a second neutrophil- activating protein. NH2-terminal amino acid sequence identity with melanoma growth stimulatory activity. (PubMed id 2182761)^{1, 2, 9} Schroeder J.-M.... Christophers E. (J. Exp. Med. 1990)
5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)^{1, 4} Johnatty S.E.... . (PLoS Genet. 2010)
6. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)^{1, 4} Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
7. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)^{1, 4} Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
8. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)^{1, 4} Janssen R....Hoebee B. (J. Infect. Dis. 2007)
9. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (Protein Sci. 2004)
10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)

External Searches for CXCL1 gene

Genome Databases showing CXCL1 gene

Other Databases showing CXCL1 gene

Specialized Databases showing CXCL1 gene

Products
for CXCL1 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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