Aliases for CXCL1 Gene
Aliases for CXCL1 Gene
- C-X-C Motif Chemokine Ligand 1 2 3 5
- Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha) 2 3
- GRO1 Oncogene (Melanoma Growth Stimulating Activity, Alpha) 2 3
- Melanoma Growth Stimulating Activity, Alpha 2 3
- Neutrophil-Activating Protein 3 3 4
- Fibroblast Secretory Protein 2 3
- C-X-C Motif Chemokine 1 3 4
- GRO-Alpha(1-73) 3 4
- NAP-3 3 4
- SCYB1 3 4
- GROa 3 4
External Ids for CXCL1 Gene
- HGNC: 4602
- Entrez Gene: 2919
- Ensembl: ENSG00000163739
- OMIM: 155730
- UniProtKB: P09341
Previous HGNC Symbols for CXCL1 Gene
- MGSA
- GRO1
- FSP
Previous GeneCards Identifiers for CXCL1 Gene
- GC04P074724
- GC04P074974
- GC04P075135
- GC04P075201
- GC04P075100
- GC04P070546
Summaries for CXCL1 Gene
-
This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014]
GeneCards Summary for CXCL1 Gene
CXCL1 (C-X-C Motif Chemokine Ligand 1) is a Protein Coding gene. Diseases associated with CXCL1 include Kaposi Sarcoma and Melanoma. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include receptor binding and chemokine activity. An important paralog of this gene is CXCL2.
UniProtKB/Swiss-Prot for CXCL1 Gene
-
Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.
Additional gene information for CXCL1 Gene
- Monarch Initiative
- Search for CXCL1 at DataMed
- Search for CXCL1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL1 Gene
Genomics for CXCL1 Gene
GeneHancer (GH) Regulatory Elements for CXCL1 Gene
Promoters and enhancers for CXCL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CXCL1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CXCL1 gene promoter:
Regulatory Element Products
Genomic Locations for CXCL1 Gene
Genomic Locations for CXCL1 Gene
- chr4:73,869,392-73,871,302
- (GRCh38/hg38)
- Size:
- 1,911 bases
- Orientation:
- Plus strand
- chr4:74,735,109-74,736,959
- (GRCh37/hg19)
Genomic View for CXCL1 Gene
Genes around CXCL1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q13.3 by Ensembl
- 4q13.3 by Entrez Gene
- 4q13.3 by HGNC
CXCL1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CXCL1 Gene
Proteins for CXCL1 Gene
-
Protein details for CXCL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P09341-GROA_HUMAN
- Recommended name:
- Growth-regulated alpha protein
- Protein Accession:
- P09341
- Q9UCR7
Protein attributes for CXCL1 Gene
- Size:
- 107 amino acids
- Molecular mass:
- 11301 Da
- Quaternary structure:
- No Data Available
Protein Expression for CXCL1 Gene
Post-translational modifications for CXCL1 Gene
- N-terminal processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.
Other Protein References for CXCL1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CXCL1 (CXCL1/GRO alpha/KC/CINC-1)
- Novus Biologicals Antibodies for CXCL1
-
Abcam antibodies for CXCL1
-
Cloud-Clone Corp. Antibodies for CXCL1
- Invitrogen Antibodies for CXCL1
- antibodies-online: Search results for 263 available CXCL1 Antibodies ranked by validation data
- Compare Top CXCL1 Antibodies
-
Recommended
- 3 IHC Antibodies (anti-human)
- 8 FACS Antibodies (anti-human)
- 96 WB Antibodies (anti-human)
- 1 IHC (p) Antibody (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 86 WB Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 52 WB Antibodies (anti-rat)
- 2 Neut Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 8 FACS Antibodies (anti-human)
- 96 WB Antibodies (anti-human)
- 1 IHC (p) Antibody (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 86 WB Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 52 WB Antibodies (anti-rat)
- 2 Neut Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 8 FACS Antibodies (anti-human)
- 96 WB Antibodies (anti-human)
- 1 IHC (p) Antibody (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 86 WB Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 52 WB Antibodies (anti-rat)
- 2 Neut Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- GeneTex CXCL1 antibody for CXCL1
-
Santa Cruz Biotechnology (SCBT) Antibodies for CXCL1
- Sino Biological Antibodies for CXCL1
Protein Products
- R&D Systems Proteins and Enzymes for CXCL1 (CXCL1/GRO alpha/KC/CINC-1)
-
OriGene Purified Proteins for CXCL1
- Search Origene for MassSpec and Protein Over-expression Lysates for CXCL1
- Origene Custom Protein Services for CXCL1
- Sino Biological Recombinant Proteins for CXCL1
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for CXCL1
-
Cloud-Clone Corp. Proteins for CXCL1
- GeneTex Proteins for CXCL1
-
Abcam proteins for CXCL1
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for CXCL1
- R&D Systems Proteome Profiler Antibody Arrays, Luminex Assays, ELISAs, and other biochemical assays for CXCL1 (CXCL1/GRO alpha/KC/CINC-1)
- antibodies-online: Search results for 147 available A-SDF1A Elisa Kits ranked by validation data
- Compare Top A-SDF1A Elisa Kits
-
Recommended
- 1 Cat (Feline) ELISA Kit
- 5 Chicken ELISA Kits
- 3 Cow (Bovine) ELISA Kits
- 3 Sheep (Ovine) ELISA Kits
- 39 Rat (Rattus) ELISA Kits
- 6 Rabbit ELISA Kits
- 6 Pig (Porcine) ELISA Kits
- 30 Mouse (Murine) ELISA Kits
- 7 Monkey ELISA Kits
- 38 Human ELISA Kits
- 4 Guinea Pig ELISA Kits
- 2 Goat ELISA Kits
- 4 Dog (Canine) ELISA Kits
- 3 Cow (Bovine) ELISA Kits
- 5 Chicken ELISA Kits
- 1 Cat (Feline) ELISA Kit
- 3 Sheep (Ovine) ELISA Kits
- 39 Rat (Rattus) ELISA Kits
- 6 Rabbit ELISA Kits
- 6 Pig (Porcine) ELISA Kits
- 30 Mouse (Murine) ELISA Kits
- 7 Monkey ELISA Kits
- 38 Human ELISA Kits
- 4 Guinea Pig ELISA Kits
- 2 Goat ELISA Kits
- 4 Dog (Canine) ELISA Kits
- 3 Cow (Bovine) ELISA Kits
- 5 Chicken ELISA Kits
- 1 Cat (Feline) ELISA Kit
- 3 Sheep (Ovine) ELISA Kits
- 39 Rat (Rattus) ELISA Kits
- 6 Rabbit ELISA Kits
- 6 Pig (Porcine) ELISA Kits
- 30 Mouse (Murine) ELISA Kits
- 7 Monkey ELISA Kits
- 38 Human ELISA Kits
- 4 Guinea Pig ELISA Kits
- 2 Goat ELISA Kits
- 4 Dog (Canine) ELISA Kits
-
Abcam assays for CXCL1
No data available for DME Specific Peptides for CXCL1 Gene
Domains & Families for CXCL1 Gene
Gene Families for CXCL1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for CXCL1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CXCL1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P09341- Family:
-
- Belongs to the intercrine alpha (chemokine CxC) family.
Function for CXCL1 Gene
Molecular function for CXCL1 Gene
- UniProtKB/Swiss-Prot Function:
- Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.
Phenotypes From GWAS Catalog for CXCL1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | receptor binding | TAS | 9079638 |
| GO:0005125 | cytokine activity | IEA | -- |
| GO:0008009 | chemokine activity | IBA,TAS | -- |
| GO:0008047 | enzyme activator activity | TAS | 9079638 |
| GO:0008083 | growth factor activity | IEA | -- |
Phenotypes for CXCL1 Gene
- GenomeRNAi human phenotypes for CXCL1:
-
- Increased vaccinia virus (VACV) infection
- Lamellipodia cells
- Decreased viability in esophageal squamous lineage
- Decreased ionizing radiation sensitivity
- Increased shRNA abundance (Z-score > 2)
- Decreased viability ratio
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability after Maraba virus infection
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased cell number
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CXCL1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CXCL1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CXCL1 gene
- Search ViGene Biosciences for CXCL1
CRISPR Products
-
OriGene CRISPR knockouts for CXCL1
- genomics-online: gRNA clones - Search results for available CXCL1 gene related products
- Applied Biological Materials CRISPR for CXCL1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CXCL1
- GenScript: Design CRISPR guide RNA sequences for CXCL1
miRNA for CXCL1 Gene
- miRTarBase miRNAs that target CXCL1
miRNA Products
- Search ViGene Biosciences for CXCL1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CXCL1
- Browse OriGene Inhibitory RNA Products For CXCL1
- genomics-online: shRNA clones - Search results for available CXCL1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CXCL1 gene
Clone Products
- Sino Biological Human cDNA Clone for CXCL1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CXCL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CXCL1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available CXCL1 gene related products
- orf clones - Search results for available CXCL1 gene related products
- Applied Biological Materials Clones for CXCL1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CXCL1
-
ViGene Biosciences adenoviral particle packaged cDNA for CXCL1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CXCL1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CXCL1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CXCL1 Gene
Localization for CXCL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CXCL1 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | TAS,IBA | -- |
| GO:0035580 | specific granule lumen | TAS | -- |
| GO:1904724 | tertiary granule lumen | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CXCL1 Gene
Pathways & Interactions for CXCL1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
.61
.47
|
|
| 2 | Peptide ligand-binding receptors | ||
| 3 | ERK Signaling |
.61
|
|
| 4 | Signaling by GPCR | ||
| 5 | Innate Immune System |
.61
|
|
Pathways by source for CXCL1 Gene
4 BioSystems pathways for CXCL1 Gene
14 Reactome pathways for CXCL1 Gene
2 GeneGo (Thomson Reuters) pathways for CXCL1 Gene
1 R&D Systems pathway for CXCL1 Gene
17 Qiagen pathways for CXCL1 Gene
Interacting Proteins for CXCL1 Gene
SIGNOR curated interactions for CXCL1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006935 | chemotaxis | TAS | 10820279 |
| GO:0006952 | defense response | IEA | -- |
| GO:0006954 | inflammatory response | IBA,TAS | -- |
| GO:0006955 | immune response | IBA | -- |
| GO:0007165 | signal transduction | TAS | 9725262 |
Transcripts for CXCL1 Gene
mRNA/cDNA for CXCL1 Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (94) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CXCL1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CXCL1
- genomics-online: gRNA clones - Search results for available CXCL1 gene related products
- Applied Biological Materials CRISPR for CXCL1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CXCL1
- GenScript: Design CRISPR guide RNA sequences for CXCL1
miRNA Products
- Search ViGene Biosciences for CXCL1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CXCL1
- Browse OriGene Inhibitory RNA Products For CXCL1
- genomics-online: shRNA clones - Search results for available CXCL1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CXCL1 gene
Clone Products
- Sino Biological Human cDNA Clone for CXCL1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CXCL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CXCL1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available CXCL1 gene related products
- orf clones - Search results for available CXCL1 gene related products
- Applied Biological Materials Clones for CXCL1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for CXCL1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Mesenchymal Stem Cells
- Bone (Muscoskeletal System)
- Placenta (Extraembryonic Tissues)
- Endothelium (Cardiovascular System)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Amnion (Extraembryonic Tissues)
-
Smooth Muscle (Muscoskeletal System)
-
Lung (Respiratory System)
mRNA differential expression in normal tissues according to GTEx for CXCL1 Gene
This gene is overexpressed in Spleen (x12.2).
This gene is overexpressed in Amniocyte (60.6) and Islet of Langerhans (8.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CXCL1 Gene
NURSA nuclear receptor signaling pathways regulating expression of CXCL1 Gene:
CXCL1SOURCE GeneReport for Unigene cluster for CXCL1 Gene:
Hs.789Evidence on tissue expression from TISSUES for CXCL1 Gene
- Blood(4.6)
- Skin(4.5)
- Lung(3.1)
- Spleen(3.1)
- Intestine(3)
- Nervous system(2.9)
- Heart(2.6)
- Bone marrow(2.5)
- Liver(2.5)
- Kidney(2.3)
- Muscle(2.3)
- Lymph node(2)
- Stomach(2)
Primer Products
-
OriGene qPCR primer pairs for CXCL1
- genomics-online: primer clones - Search results for available CXCL1 gene related products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCL1 Gene
Orthologs for CXCL1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CXCL1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | -- 34 |
|
ManyToMany | |
| CXCL3 34 |
|
ManyToMany | |||
| GRO1 34 |
|
ManyToMany | |||
| mouse (Mus musculus) |
Mammalia | Cxcl1 34 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | -- 34 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany |
- Species where no ortholog for CXCL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for CXCL1 Gene
(13) SIMAP similar genes for CXCL1 Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for CXCL1 Gene
Variants for CXCL1 Gene
| SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1001317244 | -- | 73,871,314(+) | C/A | downstream_transcript_variant | |
| rs1001588641 | -- | 73,869,158(+) | G/A/T | upstream_transcript_variant | |
| rs1001871719 | -- | 73,870,381(+) | T/C | intron_variant | |
| rs1002558056 | -- | 73,871,398(+) | G/A | downstream_transcript_variant | |
| rs1002606331 | -- | 73,867,893(+) | A/G | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1001725 | CNV | gain | 25217958 |
| nsv525980 | CNV | gain | 19592680 |
Residual Variation Intolerance Score:
59.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.98;
20.15% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CXCL1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CXCL1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL1 Gene
Disorders for CXCL1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| kaposi sarcoma |
|
|
| melanoma |
|
|
| rheumatoid arthritis |
|
|
| helicobacter pylori infection |
|
|
| gastritis |
|
Search CXCL1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CXCL1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL1 Gene
Publications for CXCL1 Gene
- Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population. (PMID: 15843053) Tamura Y … Hohjoh H (Neuroscience letters 2005) 3 22 44 58
- Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms. (PMID: 10095777) Wuyts A … Van Damme J (European journal of biochemistry 1999) 3 4 22 58
- Identification of three related human GRO genes encoding cytokine functions. (PMID: 2217207) Haskill S … Sager R (Proceedings of the National Academy of Sciences of the United States of America 1990) 2 3 22 58
- Lipopolysaccharide-stimulated human monocytes secrete, apart from neutrophil-activating peptide 1/interleukin 8, a second neutrophil-activating protein. NH2-terminal amino acid sequence identity with melanoma growth stimulatory activity. (PMID: 2182761) Schröder JM … Christophers E (The Journal of experimental medicine 1990) 3 4 22 58
- Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 44 58
Products for CXCL1 Gene
- R&D Systems Antibodies for CXCL1 (CXCL1/GRO alpha/KC/CINC-1)
- R&D Systems Proteins and Enzymes for CXCL1 (CXCL1/GRO alpha/KC/CINC-1)
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for CXCL1 (CXCL1/GRO alpha/KC/CINC-1)
- Browse Primary Antibodies
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- Custom Antibody ServicesOriGene Antibodies for CXCL1
- Custom Assay ServicesOriGene ELISA Kits for CXCL1
- OriGene Purified Proteins for CXCL1
- Search Origene for MassSpec and Protein Over-expression Lysates for CXCL1
- Origene Custom Protein Services for CXCL1
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- OriGene qPCR primer pairs for CXCL1
- OriGene CRISPR knockouts for CXCL1
- OriGene ORF clones in human for CXCL1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping of latest version cDNA ORF clones for CXCL1 in any vector
- GenScript Purified and Recombinant Proteins for CXCL1
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- GenScript Custom Assay Services for CXCL1
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- GenScript: Design CRISPR guide RNA sequences for CXCL1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Sino Biological Human cDNA Clone for CXCL1
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- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for CXCL1
- Novus Biologicals proteins and lysates for CXCL1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for CXCL1
- Abcam proteins for CXCL1
- Abcam assays for CXCL1
- Find your target
- Browse Primary Antibodies
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- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for CXCL1
- Cloud-Clone Corp. Antibodies for CXCL1
- Cloud-Clone Corp. Proteins for CXCL1
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for CXCL1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for CXCL1
- VectorBuilder custom plasmid, inducible vectors for CXCL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CXCL1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 263 available A-SDF1A Antibodies ranked by validation data
- Compare Top A-SDF1A Antibodies
- Recommended
- 52 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 86 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 96 WB Antibodies (anti-human)
- 8 FACS Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 2 Neut Antibodies (anti-human)
- 52 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 86 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 96 WB Antibodies (anti-human)
- 8 FACS Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 2 Neut Antibodies (anti-human)
- 52 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 86 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 96 WB Antibodies (anti-human)
- 8 FACS Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 2 Neut Antibodies (anti-human)
- antibodies-online: Search results for 147 available A-SDF1A Elisa Kits ranked by validation data
- Compare Top A-SDF1A Elisa Kits
- Recommended
- 1 Cat (Feline) ELISA Kit
- 5 Chicken ELISA Kits
- 3 Cow (Bovine) ELISA Kits
- 4 Dog (Canine) ELISA Kits
- 2 Goat ELISA Kits
- 4 Guinea Pig ELISA Kits
- 38 Human ELISA Kits
- 7 Monkey ELISA Kits
- 30 Mouse (Murine) ELISA Kits
- 6 Pig (Porcine) ELISA Kits
- 6 Rabbit ELISA Kits
- 39 Rat (Rattus) ELISA Kits
- 3 Sheep (Ovine) ELISA Kits
- 1 Cat (Feline) ELISA Kit
- 5 Chicken ELISA Kits
- 3 Cow (Bovine) ELISA Kits
- 4 Dog (Canine) ELISA Kits
- 2 Goat ELISA Kits
- 4 Guinea Pig ELISA Kits
- 38 Human ELISA Kits
- 7 Monkey ELISA Kits
- 30 Mouse (Murine) ELISA Kits
- 6 Pig (Porcine) ELISA Kits
- 6 Rabbit ELISA Kits
- 39 Rat (Rattus) ELISA Kits
- 3 Sheep (Ovine) ELISA Kits
- 1 Cat (Feline) ELISA Kit
- 5 Chicken ELISA Kits
- 3 Cow (Bovine) ELISA Kits
- 4 Dog (Canine) ELISA Kits
- 2 Goat ELISA Kits
- 4 Guinea Pig ELISA Kits
- 38 Human ELISA Kits
- 7 Monkey ELISA Kits
- 30 Mouse (Murine) ELISA Kits
- 6 Pig (Porcine) ELISA Kits
- 6 Rabbit ELISA Kits
- 39 Rat (Rattus) ELISA Kits
- 3 Sheep (Ovine) ELISA Kits
- antibodies-online: Search results for 106 available A-SDF1A Proteins ranked by validation data
- Compare Top A-SDF1A Proteins
- GeneTex CXCL1 antibody for CXCL1
- GeneTex Proteins for CXCL1
- ViGene Biosciences adenoviral particle packaged cDNA for CXCL1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CXCL1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CXCL1 gene
- Search ViGene Biosciences for CXCL1
- Santa Cruz Biotechnology (SCBT) Antibodies for CXCL1
- Search Santa Cruz Biotechnology (SCBT) for CXCL1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CXCL1
- Horizon Cell Lines for CXCL1
- genomics-online: cdna clones - Search results for available A-SDF1A gene related products
- orf clones - Search results for available A-SDF1A gene related products
- genomics-online: gRNA clones - Search results for available A-SDF1A gene related products
- genomics-online: primer clones - Search results for available A-SDF1A gene related products
- genomics-online: shRNA clones - Search results for available A-SDF1A gene related products
Sources for CXCL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew