Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CXCL1 Gene

protein-coding   GIFtS: 62
GCID: GC04P074724

Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating...

(Previous names: GRO1 oncogene (melanoma growth stimulating activity, alpha),...)
(Previous symbols: MGSA, GRO1, FSP)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity,
Alpha)1 2
     C-X-C Motif Chemokine 12 3
GRO11 2 3 5     GROa2
MGSA1 2 3 5     MGSA-a2
FSP1 2     GRO1 Oncogene (Melanoma Growth-Stimulating Activity)2
Fibroblast Secretory Protein1 2     Growth-Regulated Alpha Protein2
GRO1 Oncogene (Melanoma Growth Stimulating Activity, Alpha)1 2     Melanoma Growth Stimulatory Activity Alpha2
Neutrophil-Activating Protein 32 3     MGSA Alpha2
GRO-alpha(1-73)2 3     GRO3
NAP-32 3     GROA3
SCYB12 3     Melanoma Growth Stimulatory Activity3

External Ids:    HGNC: 46021   Entrez Gene: 29192   Ensembl: ENSG000001637397   OMIM: 1557305   UniProtKB: P093413   

Export aliases for CXCL1 gene to outside databases

Previous GC identifers: GC04P074974 GC04P075135 GC04P075201 GC04P075100 GC04P070546


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CXCL1 Gene:
This gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor
that signal through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and
as a chemoattractant for neutrophils. Aberrant expression this protein is associated with the growth and
progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic
activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is
found on chromosome 4. (provided by RefSeq, Jan 2012)

GeneCards Summary for CXCL1 Gene: 
CXCL1 (chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)) is a protein-coding gene. Diseases associated with CXCL1 include alcoholic neuropathy, and tonsillitis, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Chemokine signaling pathway. GO annotations related to this gene include chemokine activity and receptor binding. An important paralog of this gene is PPBP.

UniProtKB/Swiss-Prot: GROA_HUMAN, P09341
Function: Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on
endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and
GRO-alpha(6-73) show a 30-fold higher chemotactic activity

Gene Wiki entry for CXCL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_022778.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CXCL1 gene promoter:
         Bach1   C/EBPbeta   STAT1   AML1a   NF-kappaB2   MyoD   STAT1beta   NF-kappaB1   Evi-1   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXCL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CXCL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3

CXCL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCL1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P074724:  view genomic region     (about GC identifiers)

Start:
74,735,109 bp from pter      End:
74,736,959 bp from pter
Size:
1,851 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GROA_HUMAN, P09341 (See protein sequence)
Recommended Name: Growth-regulated alpha protein precursor  
Size: 107 amino acids; 11301 Da
Subcellular location: Secreted
4 PDB 3D structures from and Proteopedia for CXCL1:
1MGS (3D)        1MSG (3D)        1MSH (3D)        1ROD (3D)    
Secondary accessions: Q9UCR7

Explore the universe of human proteins at neXtProt for CXCL1: NX_P09341

Explore proteomics data for CXCL1 at MOPED 

Post-translational modifications:

  • UniProtKB: N-terminal processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) are produced by proteolytic
    cleavage after secretion from peripheral blood monocytes
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P09341

  • CXCL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CXCL1 Protein Expression
    REFSEQ proteins: NP_001502.1  
    ENSEMBL proteins: 
     ENSP00000379110  
    Reactome Protein details: P09341
    Human Recombinant Protein Products for CXCL1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CXCL1 (CXCL1/GRO alpha/KC/CINC-1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CXCL1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CXCL1
    GenScript Purified and Recombinant Proteins for CXCL1
    Novus Biologicals CXCL1 Proteins
    Novus Biologicals CXCL1 Lysates
    Sino Biological Recombinant Protein for CXCL1
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CXCL1
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    CXCL1 for ontologies           About GeneDecksing



    CXCL1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CXCL1 (CXCL1/GRO alpha/KC/CINC-1)
    OriGene Antibodies for CXCL1
    OriGene Custom Antibody Services for CXCL1
    GenScript Superior Antibodies for CXCL1
    Novus Biologicals CXCL1 Antibodies
    Abcam antibodies for CXCL1
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for CXCL1
    LSBio Antibodies in human, mouse, rat for CXCL1 

    Assay Products for CXCL1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CXCL1
    R&D Systems ELISAs for CXCL1 (CXCL1/GRO alpha/KC/CINC-1)         (see all)
    GenScript Custom Assay Services for CXCL1
    Enzo Life Sciences assays for CXCL1
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands

    3 InterPro protein domains:
     IPR001811 Chemokine_IL8-like_dom
     IPR001089 Chemokine_CXC
     IPR018048 Chemokine_CXC_CS

    Graphical View of Domain Structure for InterPro Entry P09341

    ProtoNet protein and cluster: P09341

    1 Blocks protein domain: IPB002473 Interleukin-8 signature

    UniProtKB/Swiss-Prot: GROA_HUMAN, P09341
    Similarity: Belongs to the intercrine alpha (chemokine CxC) family


    CXCL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GROA_HUMAN, P09341
    Function: Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on
    endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and
    GRO-alpha(6-73) show a 30-fold higher chemotactic activity

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS10820279
    GO:0008009chemokine activity IEA--
    GO:0008047enzyme activator activity TAS9079638
    GO:0008083growth factor activity IEA--
         
    CXCL1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CXCL1:
     Decreased focal adhesion (FA)   Metaphase cells 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cxcl1):
     cardiovascular system 

    CXCL1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cxcl1tm1Wabo for CXCL1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CXCL1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CXCL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CXCL1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CXCL1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCL1
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL1:
    hsa-miR-3163 hsa-miR-607 hsa-miR-873 hsa-miR-641 hsa-miR-539 hsa-miR-3662 hsa-miR-3617
    SwitchGear 3'UTR luciferase reporter plasmidCXCL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CXCL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CXCL1
    Sirion Biotech Customized adenovirus for overexpression of CXCL1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CXCL1 (see all 8)
    OriGene ORF clones in mouse, rat for CXCL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CXCL1 (NM_001511)
    Sino Biological Human cDNA Clone for CXCL1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL1
    Sirion Biotech Customized lentivirus for stable overexpression of CXCL1 
                         Customized lentivirus expression plasmids for stable overexpression of CXCL1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CXCL1
    Search LifeMap BioReagents cell lines for CXCL1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CXCL1 About   (see all 21)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    IL-6 Pathway0.61
    MIF Regulation of Innate Immune Cells0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43
    2Chemokine Signaling
    Chemokine Signaling0.33
    Chemokine signaling pathway0.33
    3Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.46
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    5Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CXCL1 (see all 17)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    MIF Mediated Glucocorticoid Regulation

    2 GeneGo (Thomson Reuters) Pathways for CXCL1
        Cytokine production by Th17 cells in CF (Mouse model)
    Cytokine production by Th17 cells in CF

    4 BioSystems Pathways for CXCL1
        Cytokines and Inflammatory Response
    Senescence and Autophagy
    Spinal Cord Injury
    IL23-mediated signaling events


    5/8        Reactome Pathways for CXCL1 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    5/9         Kegg Pathways  (Kegg details for CXCL1) (see all 9):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    NOD-like receptor signaling pathway
    TNF signaling pathway
    Epithelial cell signaling in Helicobacter pylori infection


    CXCL1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CXCL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    139/163 Interacting proteins for CXCL1 (P093413 ENSP000003791104) via UniProtKB, MINT, STRING, and/or I2D (see all 163) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CXCR2P250253, ENSP000003196354I2D: score=2 STRING: ENSP00000319635
    MMP9P147803, ENSP000003614054I2D: score=1 STRING: ENSP00000361405
    CXCR1P250243, ENSP000002956834I2D: score=2 STRING: ENSP00000295683
    DARCQ165703, ENSP000003571034I2D: score=3 STRING: ENSP00000357103
    HIPK2Q9H2X63I2D: score=1 
    MMP12P399003I2D: score=1 
    PIGRP018333I2D: score=1 
    ACKR3ENSP000002729284STRING: ENSP00000272928
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ANXA1ENSP000002574974STRING: ENSP00000257497
    APPENSP000002849814STRING: ENSP00000284981
    BDKRB2ENSP000003077134STRING: ENSP00000307713
    C3ENSP000002459074STRING: ENSP00000245907
    C3AR1ENSP000003020794STRING: ENSP00000302079
    C5AR1ENSP000003471974STRING: ENSP00000347197
    CCL16ENSP000002932754STRING: ENSP00000293275
    CCL19ENSP000003088154STRING: ENSP00000308815
    CCL20ENSP000003516714STRING: ENSP00000351671
    CCL21ENSP000002596074STRING: ENSP00000259607
    CCL25ENSP000003750864STRING: ENSP00000375086
    CCL27ENSP000002596314STRING: ENSP00000259631
    CCL28ENSP000003544164STRING: ENSP00000354416
    CCL5ENSP000002932724STRING: ENSP00000293272
    CCR1ENSP000002961404STRING: ENSP00000296140
    CCR3ENSP000003500034STRING: ENSP00000350003
    CCR5ENSP000002923034STRING: ENSP00000292303
    CCR6ENSP000003393934STRING: ENSP00000339393
    CCR7ENSP000002466574STRING: ENSP00000246657
    CCR8ENSP000003264324STRING: ENSP00000326432
    CXCL10ENSP000003056514STRING: ENSP00000305651
    CXCL11ENSP000003068844STRING: ENSP00000306884
    CXCL13ENSP000002867584STRING: ENSP00000286758
    CXCL16ENSP000002937784STRING: ENSP00000293778
    CXCL3ENSP000002960264STRING: ENSP00000296026
    CXCL5ENSP000002960274STRING: ENSP00000296027
    CXCL6ENSP000002263174STRING: ENSP00000226317
    CXCL9ENSP000003549014STRING: ENSP00000354901
    CXCR5ENSP000002921744STRING: ENSP00000292174
    CXCR6ENSP000003044144STRING: ENSP00000304414
    FPR1ENSP000003027074STRING: ENSP00000302707
    FPR2ENSP000003401914STRING: ENSP00000340191
    HCAR2ENSP000003750664STRING: ENSP00000375066
    IL12BENSP000002312284STRING: ENSP00000231228
    IL12RB1ENSP000003144254STRING: ENSP00000314425
    IL23AENSP000002285344STRING: ENSP00000228534
    IL23RENSP000003213454STRING: ENSP00000321345
    JAK2ENSP000003710674STRING: ENSP00000371067
    KNG1ENSP000002650234STRING: ENSP00000265023
    LPAR2ENSP000003846654STRING: ENSP00000384665
    NPYENSP000002421524STRING: ENSP00000242152
    OPRM1ENSP000003946244STRING: ENSP00000394624
    PNOCENSP000003019084STRING: ENSP00000301908
    POMCENSP000002647084STRING: ENSP00000264708
    PPBPENSP000002960284STRING: ENSP00000296028
    PTGDR2ENSP000003328124STRING: ENSP00000332812
    RGS1ENSP000003564294STRING: ENSP00000356429
    RGS10ENSP000003580994STRING: ENSP00000358099
    SSTENSP000002876414STRING: ENSP00000287641
    TYK2ENSP000002648184STRING: ENSP00000264818
    ADCY1ENSP000002973234STRING: ENSP00000297323
    ADCY4ENSP000003121264STRING: ENSP00000312126
    ADCY5ENSP000004193614STRING: ENSP00000419361
    ADCY6ENSP000003114054STRING: ENSP00000311405
    ADCY7ENSP000002542354STRING: ENSP00000254235
    ADCY8ENSP000002863554STRING: ENSP00000286355
    ADCY9ENSP000002940164STRING: ENSP00000294016
    ADORA1ENSP000003085494STRING: ENSP00000308549
    ADORA3ENSP000003587304STRING: ENSP00000358730
    ADRA2AENSP000002801554STRING: ENSP00000280155
    ADRA2BENSP000003872814STRING: ENSP00000387281
    ADRA2CENSP000003860694STRING: ENSP00000386069
    AGTR2ENSP000003609734STRING: ENSP00000360973
    APLNENSP000003054644STRING: ENSP00000305464
    APLNRENSP000002572544STRING: ENSP00000257254
    BDKRB1ENSP000002166294STRING: ENSP00000216629
    C5ENSP000002236424STRING: ENSP00000223642
    CASRENSP000002961544STRING: ENSP00000296154
    CHRM2ENSP000003199844STRING: ENSP00000319984
    CHRM4ENSP000004093784STRING: ENSP00000409378
    DRD2ENSP000003548594STRING: ENSP00000354859
    DRD3ENSP000003731694STRING: ENSP00000373169
    DRD4ENSP000001761834STRING: ENSP00000176183
    FPR3ENSP000003418214STRING: ENSP00000341821
    GALENSP000002656434STRING: ENSP00000265643
    GALR1ENSP000002997274STRING: ENSP00000299727
    GALR2ENSP000003296844STRING: ENSP00000329684
    GALR3ENSP000002490414STRING: ENSP00000249041
    GNAI2ENSP000003129994STRING: ENSP00000312999
    GNG2ENSP000003344484STRING: ENSP00000334448
    GPER1ENSP000002974694STRING: ENSP00000297469
    GPR17ENSP000002726444STRING: ENSP00000272644
    GPR18ENSP000003434284STRING: ENSP00000343428
    GPR55ENSP000003758934STRING: ENSP00000375893
    HEBP1ENSP000000149304STRING: ENSP00000014930
    HRH3ENSP000003425604STRING: ENSP00000342560
    HRH4ENSP000002569064STRING: ENSP00000256906
    HTR1AENSP000003162444STRING: ENSP00000316244
    HTR1BENSP000003589634STRING: ENSP00000358963
    HTR1DENSP000003136614STRING: ENSP00000313661
    HTR1EENSP000003077664STRING: ENSP00000307766
    HTR1FENSP000003229244STRING: ENSP00000322924
    HTR5AENSP000002879074STRING: ENSP00000287907
    LPAR1ENSP000003517554STRING: ENSP00000351755
    LPAR3ENSP000003596434STRING: ENSP00000359643
    MCHR1ENSP000002490164STRING: ENSP00000249016
    MCHR2ENSP000002818064STRING: ENSP00000281806
    MTNR1AENSP000003028114STRING: ENSP00000302811
    MTNR1BENSP000002570684STRING: ENSP00000257068
    NMSENSP000003660614STRING: ENSP00000366061
    NMUENSP000002642184STRING: ENSP00000264218
    NMUR1ENSP000003058774STRING: ENSP00000305877
    NMUR2ENSP000002552624STRING: ENSP00000255262
    NPBENSP000003327664STRING: ENSP00000332766
    NPBWR1ENSP000003302844STRING: ENSP00000330284
    NPBWR2ENSP000003587834STRING: ENSP00000358783
    NPWENSP000003300704STRING: ENSP00000330070
    NPY1RENSP000003546524STRING: ENSP00000354652
    NPY2RENSP000003325914STRING: ENSP00000332591
    NPY4RENSP000003634314STRING: ENSP00000363431
    NPY5RENSP000003393774STRING: ENSP00000339377
    OPRD1ENSP000002349614STRING: ENSP00000234961
    OPRK1ENSP000002655724STRING: ENSP00000265572
    OPRL1ENSP000003367644STRING: ENSP00000336764
    OXER1ENSP000003679304STRING: ENSP00000367930
    P2RY12ENSP000003072594STRING: ENSP00000307259
    P2RY13ENSP000003203764STRING: ENSP00000320376
    P2RY14ENSP000003083614STRING: ENSP00000308361
    P2RY4ENSP000003636434STRING: ENSP00000363643
    PDYNENSP000002173054STRING: ENSP00000217305
    PENKENSP000003242484STRING: ENSP00000324248
    PMCHENSP000003322254STRING: ENSP00000332225
    PPYENSP000002259924STRING: ENSP00000225992
    PTGER3ENSP000003490034STRING: ENSP00000349003
    PYYENSP000003531984STRING: ENSP00000353198
    RGS14ENSP000003862294STRING: ENSP00000386229
    RGS18ENSP000003564304STRING: ENSP00000356430
    RGS19ENSP000003331944STRING: ENSP00000333194
    RGS20ENSP000002973134STRING: ENSP00000297313
    RGS4ENSP000003971814STRING: ENSP00000397181
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis TAS10820279
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0007165signal transduction TAS10820279
    GO:0007186G-protein coupled receptor signaling pathway TAS10820279

    CXCL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CXCL1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CXCL1 (GROA)

    10/46 Novoseek inferred chemical compound relationships for CXCL1 gene (see all 46)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    groalpha 97.3 249 16510595 (11), 11470861 (9), 9641651 (9), 11495082 (8) (see all 68)
    grogamma 92.2 12 8702798 (4), 9553055 (2), 10695618 (1), 9054580 (1) (see all 7)
    rantes 87.6 132 10881738 (6), 12915769 (5), 12620497 (4), 10464551 (3) (see all 86)
    grobeta 87.4 14 8702798 (4), 16540656 (3), 9553055 (2), 10695618 (1) (see all 7)
    ppbp 72.9 3 7698025 (1), 10343098 (1), 9465307 (1)
    ccl3 68.3 10 17023518 (2), 18565769 (2), 12851650 (1), 19162037 (1) (see all 8)
    tarc 50.7 3 11533168 (1), 15975968 (1), 16316467 (1)
    vegf 36.7 21 18832182 (3), 19176759 (3), 15958549 (2), 17406066 (1) (see all 14)
    sulfapyridine 36.5 2 12231210 (2)
    leukotriene b4 28.4 14 18576322 (5), 18515326 (1), 20008148 (1), 9353042 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about CXCL1 / GROA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CXCL1 gene: 
    NM_001511.3  

    Unigene Cluster for CXCL1:

    Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
    Hs.789  [show with all ESTs]
    Unigene Representative Sequence: NR_046035
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000509101 ENST00000395761(uc003hhh.2)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCL1
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL1:
    hsa-miR-3163 hsa-miR-607 hsa-miR-873 hsa-miR-641 hsa-miR-539 hsa-miR-3662 hsa-miR-3617
    SwitchGear 3'UTR luciferase reporter plasmidCXCL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CXCL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCL1
    Clone
    Products:
         
    OriGene clones in human, mouse for CXCL1 (see all 8)
    OriGene ORF clones in mouse, rat for CXCL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CXCL1 (NM_001511)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL1
    Sirion Biotech Customized lentivirus for stable overexpression of CXCL1 
                         Customized lentivirus expression plasmids for stable overexpression of CXCL1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CXCL1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CXCL1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXCL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL1

    Additional mRNA sequence: 

    BC011976.1 BT006880.1 J03561.1 NR_046035.1 X12510.1 

    3 DOTS entries:

    DT.446046  DT.100777292  DT.121241560 

    24/94 AceView cDNA sequences (see all 94):

    BF000107 CA307413 BC011976 X12510 AI362592 NM_001511 BQ021711 BM737792 
    BQ000742 BU626840 BM994730 CB140372 CB149087 AA315570 AI609640 AW261997 
    D82649 CA438155 AI811850 W46900 BM997231 CB305578 AW081601 BM760210 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CXCL1 expression in normal human tissues (normalized intensities)      CXCL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGAAACTTT
    CXCL1 Expression
    About this image


    CXCL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/22 selected tissues (see all 22) fully expand
     
     Mesenchymal Stem Cells
             Decidua-derived mesenchymal stem cells
             Human Umbilical Mesenchymal Stem Cells (HUMSC)   
     
     Adipose (Muscoskeletal System)    fully expand to see all 3 entries
             Body Subcutaneous White Adipose
             Human Preadipocyte-visceral (HPA-v)   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 3 entries
             Wharton's jelly-derived stem cells
             Human umbilical Smooth Muscle (HUSM)   
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Human umbilical vein endothelial cells (HUVEC)
             Human Intestinal Microvascular Endothelial Cells (HIMEC)   
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Decidua-derived mesenchymal stem cells
             Placenta Pericyte   

    See CXCL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CXCL1

    SOURCE GeneReport for Unigene cluster: Hs.789
        SABiosciences Expression via Pathway-Focused PCR Arrays including CXCL1 (see all 16): 
              Neurogenesis in human mouse rat
              Nephrotoxicity in human mouse rat
              Growth Factors in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Wound Healing in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CXCL1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CXCL1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXCL1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CXCL1 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cxcl15
    Cxcl31
    chemokine (C-X-C motif) ligand 15
    chemokine (C-X-C motif) ligand 31
    70.03(n)1
    57.58(a)1
      5 (44.78 cM)5
    3301221  NM_203320.21  NP_976065.11 
     908912415 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    37(a)
    possible ortholog
    4(50379773-50381069)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    38(a)
    possible ortholog
    6(60123888-60134622)


    ENSEMBL Gene Tree for CXCL1 (if available)
    TreeFam Gene Tree for CXCL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CXCL1 gene
    PPBP2  PF42  PF4V12  CXCL62  CXCL32  CXCL52  CXCL22  IL82  
    13 SIMAP similar genes for CXCL1 using alignment to 1 protein entry:     GROA_HUMAN:
    MGSA alpha    CXCL3    CXCL2    PPBP    CXCL5    CXCL6
    CXCL9    PF4    PF4V1    CXCL10    IL8    CXCL11
    CXCL12

    CXCL1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CXCL1
    PGOHUM00000245590


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/177 SNPs in CXCL1 are shown (see all 177)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1824091421,2
    --74733122(+) AGAAAC/TAATTG 2 -- us2k10--------
    rs1869144671,2
    --74733165(+) GTCTGC/TTTTAA 2 -- us2k10--------
    rs785726271,2
    F--74733296(+) ATTCTG/ATCTTC 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs738288961,2
    C--74733345(+) TATATG/AGTGTT 2 -- us2k12Minor allele frequency- A:0.07WA 120
    rs1924422481,2
    C--74733351(+) GTGTTA/GTATAC 2 -- us2k10--------
    rs1850932331,2
    --74733454(+) ATATAA/TATATA 2 -- us2k10--------
    rs49929781,2
    C--74733474(+) ATATAT/AATATA 2 -- us2k1 tfbs31Minor allele frequency- A:0.00NA 2
    rs68252951,2
    C--74733482(+) atataA/Tatata 2 -- us2k1 tfbs30--------
    rs285761701,2
    C--74733482(+) ATATAT/AATATA 2 -- us2k1 tfbs31Minor allele frequency- A:0.00WA 2
    rs285305141,2
    C--74733555(+) TTTTTA/TTTAAA 2 -- us2k1 trp31Minor allele frequency- T:0.00CSA 1

    HapMap Linkage Disequilibrium report for CXCL1 (74735109 - 74736959 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CXCL1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv525980CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CXCL1
    DNA2.0 Custom Variant and Variant Library Synthesis for CXCL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 155730    OMIM disorders: --

    20/88 diseases for CXCL1 (see all 88):    About MalaCards
    alcoholic neuropathy    tonsillitis    endometritis    yellow fever
    keratitis    klebsiella    peptic ulcer    lymphangioleiomyomatosis
    melanoma    bacterial meningitis    adult respiratory distress syndrome    polymyalgia rheumatica
    chronic granulomatous disease    h. pylori infection    meningitis    duodenal ulcer
    duodenitis    essential thrombocythemia    kaposi's sarcoma    abdominal aortic aneurysm

    2 diseases from the University of Copenhagen DISEASES database for CXCL1:
    Melanoma     Lung disease

    CXCL1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/58 Novoseek inferred disease relationships for CXCL1 gene (see all 58)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 65.4 25 9730682 (1), 10392755 (1), 11371564 (1), 12549928 (1) (see all 23)
    necrosis 58.3 35 9215253 (2), 1744577 (1), 8245503 (1), 9143736 (1) (see all 32)
    melanoma 50.4 46 11406569 (2), 18056965 (2), 11719444 (2), 16098041 (2) (see all 29)
    nasal polyps 47.3 7 16608789 (4), 10889487 (2), 17703097 (1)
    tumors 44.1 68 18451219 (4), 16618733 (3), 19276354 (2), 12427307 (2) (see all 46)
    bronchoalveolar lavage fluid 41.5 4 19155472 (1), 14662873 (1), 7582292 (1)
    rheumatoid arthritis 39.1 6 10437780 (2), 10881738 (2), 9232436 (1), 18576322 (1)
    gastritis 35 1 15557597 (1)
    pneumonia 25.5 1 18345025 (1)
    response acute phase 25.2 1 11916915 (1)

    Genetic Association Database (GAD): CXCL1
    Human Genome Epidemiology (HuGE) Navigator: CXCL1 (8 documents)

    Export disorders for CXCL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CXCL1 gene, integrated from 9 sources (see all 551):
    (articles sorted by number of sources associating them with CXCL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population. (PubMed id 15843053)1, 4, 9 Tamura Y....Hohjoh H. (2005)
    2. Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms. (PubMed id 10095777)1, 2, 9 Wuyts A.... Van Damme J. (1999)
    3. Identification of three related human GRO genes encoding cytokine functions. (PubMed id 2217207)1, 3, 9 Haskill S.... Sager R. (1990)
    4. Lipopolysaccharide-stimulated human monocytes secrete, apart from neutrophil-activating peptide 1/interleukin 8, a second neutrophil- activating protein. NH2-terminal amino acid sequence identity with melanoma growth stimulatory activity. (PubMed id 2182761)1, 2, 9 Schroeder J.-M.... Christophers E. (1990)
    5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    6. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
    7. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)
    8. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (2007)
    9. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2919 HGNC: 4602 AceView: CXCL1 Ensembl:ENSG00000163739 euGenes: HUgn2919
    ECgene: CXCL1 Kegg: 2919 H-InvDB: CXCL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CXCL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CXCL1 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CXCL1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CXCL1 gene:
    Search GeneIP for patents involving CXCL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CXCL1 (CXCL1/GRO alpha/KC/CINC-1)   Browse Cell Culture Products  
     ELISAs for CXCL1 (CXCL1/GRO alpha/KC/CINC-1)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents for CXCL1 (CXCL1/GRO alpha/KC/CINC-1)  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for CXCL1 (CXCL1/GRO alpha/KC/CINC-1)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for CXCL1 (CXCL1/GRO alpha/KC/CINC-1)  
     OriGene Antibodies for CXCL1   OriGene RNAi products in human, mouse, rat for CXCL1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for CXCL1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CXCL1  
     OriGene qSTAR qPCR primer pairs in human, mouse for CXCL1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CXCL1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CXCL1   OriGene Custom Protein Services for CXCL1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CXCL1
     QIAGEN SeqTarget long-range PCR primers for resequencing CXCL1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCL1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCL1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXCL1
     GenScript Purified and Recombinant Proteins for CXCL1 GenScript cDNA clones with any tag delivered in your preferred vector for CXCL1
     GenScript Custom Assay Services for CXCL1 GenScript Superior Antibodies for CXCL1
     GenScript Custom overexpressing Cell Line Services for CXCL1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CXCL1 promoter
     Search Chromatin IP Primers for CXCL1
     RT2 qPCR Primer Assay in human, mouse, rat CXCL1
     GNC Network for CXCL1
     SABiosciences PCR Arrays including human, mouse, rat CXCL1
     Search Tocris compounds for CXCL1 (GROA)
     Proteins and Antibodies for CXCL1
     Browse Sino Biological Cell Lysates
     cDNA Clones for CXCL1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Assays for CXCL1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CXCL1 antibodies
     CXCL1 proteins
     CXCL1 lysates
     Antibodies for CXCL1
     See all of Abcam's Antibodies, Kits and Proteins for CXCL1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CXCL1




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for CXCL1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL1
     SwitchGear 3'UTR luciferase reporter plasmids for CXCL1
     SwitchGear Promoter luciferase reporter plasmids for CXCL1
     ThermoFisher Antibodies for CXCL1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CXCL1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CXCL1
    Customized:
     lentivirus for stable overexpression of CXCL1
     lentivirus expression plasmids for stable overexpression of CXCL1
     adenovirus for overexpression of CXCL1
     LSBio Antibodies in human, mouse, rat for CXCL1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CXCL1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4