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Aliases for CXCL1 Gene

Aliases for CXCL1 Gene

  • C-X-C Motif Chemokine Ligand 1 2 3
  • Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha) 2 3 5
  • GRO1 Oncogene (Melanoma Growth Stimulating Activity, Alpha) 2 3
  • Neutrophil-Activating Protein 3 3 4
  • Fibroblast Secretory Protein 2 3
  • C-X-C Motif Chemokine 1 3 4
  • GRO-Alpha(1-73) 3 4
  • NAP-3 3 4
  • SCYB1 3 4
  • GROa 3 4
  • GRO1 3 4
  • MGSA 3 4
  • GRO1 Oncogene (Melanoma Growth-Stimulating Activity) 3
  • Melanoma Growth Stimulating Activity, Alpha 3
  • Melanoma Growth Stimulatory Activity Alpha 3
  • Melanoma Growth Stimulating Activity 2
  • Melanoma Growth Stimulatory Activity 4
  • MGSA Alpha 3
  • MGSA-A 3
  • Alpha 2
  • FSP 3
  • GRO 4

External Ids for CXCL1 Gene

Previous HGNC Symbols for CXCL1 Gene

  • MGSA
  • GRO1
  • FSP

Previous GeneCards Identifiers for CXCL1 Gene

  • GC04P074724
  • GC04P074974
  • GC04P075135
  • GC04P075201
  • GC04P075100
  • GC04P070546

Summaries for CXCL1 Gene

Entrez Gene Summary for CXCL1 Gene

  • This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014]

GeneCards Summary for CXCL1 Gene

CXCL1 (C-X-C Motif Chemokine Ligand 1) is a Protein Coding gene. Diseases associated with CXCL1 include rheumatoid arthritis and gastritis. Among its related pathways are Signaling by GPCR and ERK Signaling. GO annotations related to this gene include receptor binding and chemokine activity. An important paralog of this gene is PF4.

UniProtKB/Swiss-Prot for CXCL1 Gene

  • Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.

Gene Wiki entry for CXCL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL1 Gene

Genomics for CXCL1 Gene

Regulatory Elements for CXCL1 Gene

Promoters for CXCL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CXCL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CXCL1 Gene

Chromosome:
4
Start:
73,869,392 bp from pter
End:
73,871,302 bp from pter
Size:
1,911 bases
Orientation:
Plus strand

Genomic View for CXCL1 Gene

Genes around CXCL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL1 Gene

Proteins for CXCL1 Gene

  • Protein details for CXCL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09341-GROA_HUMAN
    Recommended name:
    Growth-regulated alpha protein
    Protein Accession:
    P09341
    Secondary Accessions:
    • Q9UCR7

    Protein attributes for CXCL1 Gene

    Size:
    107 amino acids
    Molecular mass:
    11301 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CXCL1 Gene

neXtProt entry for CXCL1 Gene

Proteomics data for CXCL1 Gene at MOPED

Post-translational modifications for CXCL1 Gene

  • N-terminal processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CXCL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CXCL1 (CXCL1/GRO alpha/KC/CINC-1)

No data available for DME Specific Peptides for CXCL1 Gene

Domains & Families for CXCL1 Gene

Gene Families for CXCL1 Gene

Protein Domains for CXCL1 Gene

Suggested Antigen Peptide Sequences for CXCL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P09341

UniProtKB/Swiss-Prot:

GROA_HUMAN :
  • Belongs to the intercrine alpha (chemokine CxC) family.
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL1: view

Function for CXCL1 Gene

Molecular function for CXCL1 Gene

UniProtKB/Swiss-Prot Function:
Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.
genes like me logo Genes that share phenotypes with CXCL1: view

Animal Model Products

miRNA for CXCL1 Gene

miRTarBase miRNAs that target CXCL1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CXCL1 Gene

Localization for CXCL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CXCL1 Gene COMPARTMENTS Subcellular localization image for CXCL1 gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
plasma membrane 2
cytoskeleton 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for CXCL1 Gene

Pathways & Interactions for CXCL1 Gene

genes like me logo Genes that share pathways with CXCL1: view

SIGNOR curated interactions for CXCL1 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for CXCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis TAS 10820279
GO:0006955 immune response IEA,IBA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 10820279
GO:0008283 cell proliferation TAS 8380167
GO:0008285 negative regulation of cell proliferation TAS 9551928
genes like me logo Genes that share ontologies with CXCL1: view

Drugs & Compounds for CXCL1 Gene

(20) Drugs for CXCL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(26) Additional Compounds for CXCL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CXCL1: view

Transcripts for CXCL1 Gene

mRNA/cDNA for CXCL1 Gene

Unigene Clusters for CXCL1 Gene

Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL1 Gene

No ASD Table

Relevant External Links for CXCL1 Gene

GeneLoc Exon Structure for
CXCL1
ECgene alternative splicing isoforms for
CXCL1

Expression for CXCL1 Gene

mRNA expression in normal human tissues for CXCL1 Gene

mRNA differential expression in normal tissues according to GTEx for CXCL1 Gene

This gene is overexpressed in Spleen (x12.2).

Protein differential expression in normal tissues from HIPED for CXCL1 Gene

This gene is overexpressed in Amniocyte (60.6) and Islet of Langerhans (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CXCL1 Gene



SOURCE GeneReport for Unigene cluster for CXCL1 Gene Hs.789

genes like me logo Genes that share expression patterns with CXCL1: view

Protein tissue co-expression partners for CXCL1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CXCL1 Gene

Orthologs for CXCL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXCL1 35
  • 98.75 (n)
  • 100 (a)
CXCL1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 81 (a)
ManyToMany
CXCL3 36
  • 78 (a)
ManyToMany
GRO1 36
  • 50 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 41 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cxcl1 36
  • 60 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 40 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 38 (a)
OneToMany
Species with no ortholog for CXCL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL1 Gene

ENSEMBL:
Gene Tree for CXCL1 (if available)
TreeFam:
Gene Tree for CXCL1 (if available)

Paralogs for CXCL1 Gene

Paralogs for CXCL1 Gene

(13) SIMAP similar genes for CXCL1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CXCL1 Gene

genes like me logo Genes that share paralogs with CXCL1: view

Variants for CXCL1 Gene

Sequence variations from dbSNP and Humsavar for CXCL1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs4074 -- 73,870,427(+) TCGGA(A/G)AACTC intron-variant
rs930113 -- 73,870,184(+) CCTGG(A/C)GTCCC intron-variant
rs1814092 -- 73,870,518(+) CATTG(C/T)AGTGA intron-variant
rs2071425 -- 73,869,527(+) GTGGC(A/G)CTGCT nc-transcript-variant, reference, synonymous-codon
rs1957068 -- 73,871,188(+) AGGGG(C/T)TTAAT nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CXCL1 Gene

Variant ID Type Subtype PubMed ID
nsv525980 CNV Gain 19592680

Variation tolerance for CXCL1 Gene

Residual Variation Intolerance Score: 59.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CXCL1 Gene

HapMap Linkage Disequilibrium report
CXCL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL1 Gene

Disorders for CXCL1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for CXCL1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
rheumatoid arthritis
  • rheumatoid arthritis, progression of
gastritis
  • acute gastric mucosal erosion
meningitis
asthma
  • asthma, protection against
pneumonia
  • acute pneumonia
- elite association - COSMIC cancer census association via MalaCards
Search CXCL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CXCL1

Genetic Association Database (GAD)
CXCL1
Human Genome Epidemiology (HuGE) Navigator
CXCL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CXCL1
genes like me logo Genes that share disorders with CXCL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL1 Gene

Publications for CXCL1 Gene

  1. Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population. (PMID: 15843053) Tamura Y. … Hohjoh H. (Neurosci. Lett. 2005) 3 23 48 67
  2. Identification of three related human GRO genes encoding cytokine functions. (PMID: 2217207) Haskill S. … Sager R. (Proc. Natl. Acad. Sci. U.S.A. 1990) 2 3 23
  3. IL-17 regulates CXCL1 mRNA stability via an AUUUA/tristetraprolin-independent sequence. (PMID: 20042592) Datta S. … Hamilton T. (J. Immunol. 2010) 3 23
  4. Vascular endothelial growth factor induces protein kinase D-dependent production of proinflammatory cytokines in endothelial cells. (PMID: 19176759) Hao Q. … Tang H. (Am. J. Physiol., Cell Physiol. 2009) 3 23
  5. LPS induces GROalpha chemokine production via NF-kappaB in oral fibroblasts. (PMID: 19430878) JAPnsson D. … Nilsson B.O. (Inflamm. Res. 2009) 3 23

Products for CXCL1 Gene

Sources for CXCL1 Gene

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