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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CXCL1 Gene

protein-coding   GIFtS: 63
GCID: GC04P074724

chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating...

(Previous names: GRO1 oncogene (melanoma growth stimulating activity, alpha),...)
(Previous symbols: MGSA, GRO1, FSP)
 Explore 91 diseases affiliated with
CXCL1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CXCL1    

Aliases
for CXCL1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity,
Alpha)1 2
     Neutrophil-Activating Protein 32 3
GRO11 2 3 5     GRO-Alpha(1-73)1
MGSA1 2 3 5     C-X-C Motif Chemokine 12 3
NAP-31 2 3     GRO1 Oncogene (Melanoma Growth-Stimulating Activity)2
SCYB11 2 3     Growth-Regulated Alpha Protein2
FSP1 2     Melanoma Growth Stimulatory Activity Alpha2
GROa1 2     MGSA Alpha2
MGSA-A1     GRO3
Fibroblast Secretory Protein1 2     GROA3
GRO1 Oncogene (Melanoma Growth Stimulating Activity, Alpha)1 2     Melanoma Growth Stimulatory Activity3

External Ids:    HGNC: 46021   Entrez Gene: 29192   Ensembl: ENSG000001637397   OMIM: 1557305   UniProtKB: P093413   

Export aliases for CXCL1 gene to outside databases

Previous GC identifers: GC04P074974 GC04P075135 GC04P075201 GC04P075100 GC04P070546


Summaries
for CXCL1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CXCL1:
This gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that
signal through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a
chemoattractant for neutrophils. Aberrant expression this protein is associated with the growth and progression of
certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate
splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4.
(provided by RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: GROA_HUMAN, P09341
Function: Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on
endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and
GRO-alpha(6-73) show a 30-fold higher chemotactic activity

Gene Wiki entry for CXCL1


Genomic Views
for CXCL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_022778.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CXCL1 gene promoter:
         Bach1   C/EBPbeta   STAT1   AML1a   NF-kappaB2   MyoD   STAT1beta   NF-kappaB1   Evi-1   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CXCL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CXCL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3

CXCL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCL1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P074724:  view genomic region     (about GC identifiers)

Start:
 74,735,109 bp from pter      End:
 74,736,959 bp from pter
Size:
 1,851 bases      Orientation:
 plus strand

Proteins
for CXCL1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GROA_HUMAN, P09341 (See protein sequence)
Recommended Name: Growth-regulated alpha protein precursor  
Size: 107 amino acids; 11301 Da
Subcellular location: Secreted
4 PDB 3D structures from and Proteopedia for CXCL1:
1MGS (3D)        1MSG (3D)        1MSH (3D)        1ROD (3D)    
Secondary accessions: Q9UCR7

Explore the universe of human proteins at neXtProt for CXCL1: NX_P09341

Post-translational modifications:

  • N-terminal processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) are produced by proteolytic cleavage
    • after secretion from peripheral blood monocytes1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P09341

    • CXCL1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001502.1  
    ENSEMBL proteins: 
     ENSP00000379110  
    Reactome Protein details: P09341
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CXCL1 (CXCL1/GRO alpha/KC/CINC-1)
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: CXCL1
    OriGene Custom Protein Services for CXCL1 
    GenScript Purified and Recombinant Proteins for CXCL1
    Novus Biologicals CXCL1 Proteins
    Novus Biologicals CXCL1 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CXCL1
    Browse Proteins at Uscn

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005622intracellular ----


    CXCL1 for ontologies           About GeneDecksing



    CXCL1 Antibody Products: 
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    Novus Biologicals CXCL1 Antibodies
    Abcam antibodies for CXCL1 
    Browse Antibodies at Uscn
    ThermoFisher Antibodies for CXCL1

    Assay Products for CXCL1: 
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    OriGene Custom Immunoassay Development
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    R&D Systems ELISAs for CXCL1 (CXCL1/GRO alpha/KC/CINC-1)         (see all)
    GenScript Custom Assay Services for CXCL1
    Enzo Life Sciences assays for CXCL1
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for CXCL1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CXCL1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001811 Chemokine_IL8-like_dom
     IPR001089 Chemokine_CXC
     IPR018048 Chemokine_CXC_CS

    Graphical View of Domain Structure for InterPro Entry P09341

    ProtoNet protein and cluster: P09341

    1 Blocks protein family: IPB002473 Interleukin-8 signature

    UniProtKB/Swiss-Prot: GROA_HUMAN, P09341
    Similarity: Belongs to the intercrine alpha (chemokine CxC) family


    Function
    for CXCL1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GROA_HUMAN, P09341
    Function: Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on
    endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and
    GRO-alpha(6-73) show a 30-fold higher chemotactic activity

    miRNA
    Products:            		 OriGene 3'-UTR Clone: CXCL1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCL1
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL1:
    hsa-miR-3163 hsa-miR-607 hsa-miR-873 hsa-miR-641 hsa-miR-539 hsa-miR-3662 hsa-miR-3617
    SwitchGear 3'UTR luciferase reporter plasmid: CXCL1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXCL1 (see all 7)
    OriGene shRNA RFP: CXCL1
    OriGene siRNA: CXCL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCL1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CXCL1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CXCL1 (NM_001511)
    Sino Biological Human cDNA Clone for CXCL1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CXCL1
    Search LifeMap BioReagents cell lines for CXCL1

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CXCL1

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS9079638
    GO:0008009chemokine activity IEA--
    GO:0008047enzyme activator activity TAS9079638
    GO:0008083growth factor activity IEA--


    CXCL1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for CXCL1:
     Decreased focal adhesion (FA)   Metaphase cells 

    Animal Models:
         Mouse knock-out Cxcl1tm1Wabo for CXCL1
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Cxcl1):
     cardiovascular system 

    CXCL1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CXCL1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    8/9 pathways (see all 9)
    		PEDF Induced Signaling1.00
    		RAR-Gamma-RXR-Alpha Degradation0.54
    		MIF Mediated Glucocorticoid Regulation0.73
    		STAT3 Pathway0.47
    		MIF Regulation of Innate Immune Cells0.71
    		Endothelin-1 Signaling Pathway0.44
    		IL-6 Pathway0.61
    		Cytokine-cytokine receptor interaction0.26
    2Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		Peptide ligand-binding receptors0.61
    		GPCR ligand binding0.75
    		G alpha (i) signalling events0.44
    3Rho Family GTPases
    		Rho Family GTPases1.00
    		Molecular Mechanisms of Cancer0.51
    		ERK Signaling0.61
    4Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    5PAK Pathway
    		PAK Pathway1.00
    		Antioxidant Action of Vitamin-C0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CXCL1 (see all 17)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    MIF Mediated Glucocorticoid Regulation

    2 GeneGo (Thomson Reuters) Pathways for CXCL1
        Cytokine production by Th17 cells in CF (Mouse model)
    Cytokine production by Th17 cells in CF

    3 BioSystems Pathways for CXCL1 
        Cytokines and Inflammatory Response
    Senescence and Autophagy
    IL23-mediated signaling events

    5/8        Reactome Pathways for CXCL1 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    5/6         Kegg Pathways  (Kegg details for CXCL1) (see all 6):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    NOD-like receptor signaling pathway
    Epithelial cell signaling in Helicobacter pylori infection
    Amoebiasis


    CXCL1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CXCL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/163 Interacting proteins for CXCL1 (P093413 ENSP000003791104) via UniProtKB, MINT, STRING, and/or I2D (see all 163)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CXCR2P250253, ENSP000003196354I2D: score=2 STRING: ENSP00000319635
    MMP9P147803, ENSP000003614054I2D: score=1 STRING: ENSP00000361405
    CXCR1P250243, ENSP000002956834I2D: score=2 STRING: ENSP00000295683
    DARCQ165703, ENSP000003571034I2D: score=3 STRING: ENSP00000357103
    HIPK2Q9H2X63I2D: score=1 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis TAS10820279
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0007165signal transduction TAS9725262
    GO:0007186G-protein coupled receptor signaling pathway TAS10820279


    CXCL1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CXCL1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CXCL1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CXCL1
    10/46 Novoseek chemical compound relationships for CXCL1 gene (see all 46)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    groalpha 97.3 249 16510595 (11), 11470861 (9), 9641651 (9), 11495082 (8) (see all 68)
    grogamma 92.2 12 8702798 (4), 9553055 (2), 10695618 (1), 9054580 (1) (see all 7)
    rantes 87.6 132 10881738 (6), 12915769 (5), 12620497 (4), 10464551 (3) (see all 86)
    grobeta 87.4 14 8702798 (4), 16540656 (3), 9553055 (2), 10695618 (1) (see all 7)
    ppbp 72.9 3 7698025 (1), 10343098 (1), 9465307 (1)
    ccl3 68.3 10 17023518 (2), 18565769 (2), 12851650 (1), 19162037 (1) (see all 8)
    tarc 50.7 3 11533168 (1), 15975968 (1), 16316467 (1)
    vegf 36.7 21 18832182 (3), 19176759 (3), 15958549 (2), 17406066 (1) (see all 14)
    sulfapyridine 36.5 2 12231210 (2)
    leukotriene b4 28.4 14 18576322 (5), 18515326 (1), 20008148 (1), 9353042 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about CXCL1 / GROA 

    Transcripts
    for CXCL1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CXCL1 gene: 
    NM_001511.3  

    Unigene Cluster for CXCL1:

    Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
    Hs.789  [show with all ESTs]
    Unigene Representative Sequence: NR_046035
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000509101 ENST00000395761(uc003hhh.2)

    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL1:
    hsa-miR-3163 hsa-miR-607 hsa-miR-873 hsa-miR-641 hsa-miR-539 hsa-miR-3662 hsa-miR-3617
    SwitchGear 3'UTR luciferase reporter plasmid: CXCL1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXCL1 (see all 7)
    OriGene shRNA RFP: CXCL1
    OriGene siRNA: CXCL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCL1
    Clone
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    GenScript: all cDNA clones in your preferred vector: CXCL1 (NM_001511)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL1 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXCL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL1

    Additional cDNA sequence: 

    BC011976.1 BT006880.1 J03561.1 NR_046035.1 X12510.1 

    3 DOTS entries:

    DT.446046  DT.100777292  DT.121241560 

    24/94 AceView cDNA sequences (see all 94):

    CB149087 D82649 X12510 BQ021711 AW261997 CA307413 BU626840 BF000107 
    BM737792 CB140372 BM994730 NM_001511 BQ000742 AI609640 BC011976 AA315570 
    AI362592 CA438155 AA936997 BP337762 AI978805 BM771312 BQ001491 W46900 

    GeneLoc Exon Structure


    Expression
    for CXCL1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CXCL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGAAACTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CXCL1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesSertoli cellsTestis
    AdiposeBody Subcutaneous White AdiposeAdipose
    AdiposeVisceral White AdiposeAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 7 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    Fetal cardiomyocytes (20 weeks) (Primary Cell)Heart, Myocardium
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
    CD31, CD144 positive cells (Two-step protocol fo...)

    See CXCL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CXCL1

    SOURCE GeneReport for Unigene cluster: Hs.789
        SABiosciences Expression via Pathway-Focused PCR Arrays including CXCL1 (see all 16): 
              Neurogenesis in human mouse rat
              Nephrotoxicity in human mouse rat
              Growth Factors in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Wound Healing in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL1
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CXCL1

    Orthologs
    for CXCL1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CXCL1 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves --
    		 Uncharacterized protein
    		 40(a)
    		 1 → many
    		 4(52472071-52473367)


    ENSEMBL Gene Tree for CXCL1 (if available)
    TreeFam Gene Tree for CXCL1 (if available) 

    Paralogs
    for CXCL1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CXCL1 gene
    PPBP2  PF42  PF4V12  CXCL62  CXCL32  CXCL52  CXCL22  IL82  
    14 SIMAP similar genes for CXCL1 using alignment to 1 protein entry:     GROA_HUMAN:
    MGSA alpha    CXCL3    CXCL2    PPBP    CXCL5    CXCL6
    CXCL9    PF4    PF4V1    CXCL10    IL8    CXCL11
    CXCL12    CXCL14

    CXCL1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CXCL1
    PGOHUM00000245590


    Genomic Variants
    for CXCL1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CXCL1
    DNA2.0 Custom Variant and Variant Library Synthesis for CXCL1

    Disorders / Diseases
    for CXCL1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CXCL1 for disorders           About GeneDecksing

    OMIM gene information: 155730    OMIM disorders: --

    20/91 diseases for CXCL1 (see all 91):    About MalaCards
    melanoma    adult respiratory distress syndrome    polymyalgia rheumatica    abdominal aortic aneurysm
    peptic ulcer    aortic aneurysm    inflammatory bowel disease    duodenal ulcer
    yellow fever    chronic obstructive pulmonary disease    spastic paraplegia    essential thrombocythemia
    kaposi's sarcoma    klebsiella    chronic granulomatous disease    bacterial meningitis
    meningitis    systemic lupus erythematosus    lupus erythematosus    cytomegalovirus infection

    2 diseases from the University of Copenhagen DISEASES database for CXCL1:
    Melanoma     Lung disease

    10/58 Novoseek disease relationships for CXCL1 gene (see all 58)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 65.4 25 9730682 (1), 10392755 (1), 11371564 (1), 12549928 (1), 14688376 (1), 9435307 (1), 12231210 (1), 16083850 (1), 18315734 (1), 19430878 (1), 9553055 (1), 15005245 (1), 16213701 (1), 17665889 (1), 17703315 (1), 15008987 (1), 18504401 (1), 19494512 (1), 11112786 (1), 15100312 (1), 15937099 (1), 16540656 (1), 17138054 (1) (see top 4)
    necrosis 58.3 35 9215253 (2), 1744577 (1), 8245503 (1), 9143736 (1), 11470861 (1), 17406066 (1), 20008148 (1), 12885361 (1), 8576166 (1), 9077472 (1), 9266006 (1), 10339475 (1), 15644123 (1), 16542377 (1), 16671879 (1), 9106250 (1), 15033639 (1), 17211148 (1), 20409152 (1), 16987072 (1), 9536945 (1), 15670796 (1), 12620497 (1), 9277410 (1), 18340639 (1), 16787167 (1), 17594598 (1), 18419548 (1), 14506934 (1), 17021345 (1), 19066314 (1), 18992573 (1) (see top 4)
    melanoma 50.4 46 11406569 (2), 18056965 (2), 11719444 (2), 16098041 (2), 11112786 (2), 11773061 (2), 8384312 (1), 9143736 (1), 8419336 (1), 10702726 (1), 16001179 (1), 7551561 (1), 16452192 (1), 10523720 (1), 8340371 (1), 20030852 (1), 15218300 (1), 9725262 (1), 10096573 (1), 7638986 (1), 7509778 (1), 2217207 (1), 16799643 (1), 11371564 (1), 1316786 (1), 7518426 (1), 7698025 (1), 8576166 (1), 11112213 (1) (see top 4)
    nasal polyps 47.3 7 16608789 (4), 10889487 (2), 17703097 (1)
    tumors 44.1 68 18451219 (4), 16618733 (3), 19276354 (2), 12427307 (2), 18045955 (2), 15218300 (2), 9215253 (2), 1744577 (1), 8245503 (1), 9143736 (1), 20008148 (1), 12885361 (1), 9077472 (1), 10339475 (1), 16671879 (1), 14506934 (1), 18419548 (1), 18345025 (1), 18519689 (1), 18056965 (1), 17211148 (1), 15033639 (1), 10095777 (1), 9106250 (1), 16987072 (1), 16210641 (1), 15670796 (1), 15214968 (1), 12620497 (1), 9277410 (1), 18340639 (1), 16787167 (1), 11322447 (1), 18992573 (1), 18975380 (1), 19066314 (1), 18578857 (1), 17021345 (1), 15520179 (1), 16567391 (1), 9266006 (1), 8576166 (1), 12734381 (1), 10329603 (1), 17060621 (1), 17406066 (1) (see top 4)
    bronchoalveolar lavage fluid 41.5 4 19155472 (1), 14662873 (1), 7582292 (1)
    rheumatoid arthritis 39.1 6 10437780 (2), 10881738 (2), 9232436 (1), 18576322 (1)
    gastritis 35 1 15557597 (1)
    pneumonia 25.5 1 18345025 (1)
    response acute phase 25.2 1 11916915 (1)

    Genetic Association Database (GAD): CXCL1
    Human Genome Epidemiology (HuGE) Navigator: CXCL1 (8 documents)

    Export disorders for CXCL1 gene to outside databases

    Publications
    for CXCL1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CXCL1 gene, integrated from 9 sources (see all 538):
    (articles sorted by number of sources associating them with CXCL1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population. (PubMed id 15843053)1, 4, 9 Tamura Y....Hohjoh H. (2005)
    2. Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms. (PubMed id 10095777)1, 2, 9 Wuyts A.... Van Damme J. (1999)
    3. Identification of three related human GRO genes encoding cytokine functions. (PubMed id 2217207)1, 3, 9 Haskill S.... Sager R. (1990)
    4. Lipopolysaccharide-stimulated human monocytes secrete, apart from neutrophil-activating peptide 1/interleukin 8, a second neutrophil- activating protein. NH2-terminal amino acid sequence identity with melanoma growth stimulatory activity. (PubMed id 2182761)1, 2, 9 Schroeder J.-M.... Christophers E. (1990)
    5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The solution structure of melanoma growth stimulating activity. (PubMed id 8089846)1, 2 Fairbrother W.J.... Horuk R. (1994)
    8. Solution structure of GRO/melanoma growth stimulatory activity determined by 1H NMR spectroscopy. (PubMed id 7806518)1, 2 Kim K.S.... Sykes B.D. (1994)
    9. 1H assignment and secondary structure determination of human melanoma growth stimulating activity (MGSA) by NMR spectroscopy. (PubMed id 8397104)1, 2 Fairbrother W.J.... Horuk R. (1993)
    10. Nucleotide sequence of the human melanoma growth stimulatory activity (MGSA) gene. (PubMed id 2129556)1, 2 Baker N.E.... Richmond A. (1990)

    External Searches for CXCL1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing CXCL1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2919 HGNC: 4602 AceView: CXCL1 Ensembl:ENSG00000163739 euGenes: HUgn2919
    ECgene: CXCL1 Kegg: 2919 H-InvDB: CXCL1

    Other Databases showing CXCL1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CXCL1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CXCL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CXCL1 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CXCL1

    Intellectual Property
    for CXCL1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CXCL1 gene:
    Search GeneIP for patents involving CXCL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CXCL1 gene

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