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CXCL1 Gene

protein-coding   GIFtS: 62
GCID: GC04P074724

Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating...

(Previous names: GRO1 oncogene (melanoma growth stimulating activity, alpha),...)
(Previous symbols: MGSA, GRO1, FSP)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity,
Alpha)1 2
     C-X-C Motif Chemokine 12 3
GRO11 2 3 5     GROa2
MGSA1 2 3 5     MGSA-a2
FSP1 2     GRO1 Oncogene (Melanoma Growth-Stimulating Activity)2
Fibroblast Secretory Protein1 2     Growth-Regulated Alpha Protein2
GRO1 Oncogene (Melanoma Growth Stimulating Activity, Alpha)1 2     Melanoma Growth Stimulatory Activity Alpha2
Neutrophil-Activating Protein 32 3     MGSA Alpha2
GRO-alpha(1-73)2 3     GRO3
NAP-32 3     GROA3
SCYB12 3     Melanoma Growth Stimulatory Activity3

External Ids:    HGNC: 46021   Entrez Gene: 29192   Ensembl: ENSG000001637397   OMIM: 1557305   UniProtKB: P093413   
ORGUL members:         

Export aliases for CXCL1 gene to outside databases

Previous GC identifers: GC04P074974 GC04P075135 GC04P075201 GC04P075100 GC04P070546


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CXCL1 Gene:
This gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor
that signal through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and
as a chemoattractant for neutrophils. Aberrant expression this protein is associated with the growth and
progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic
activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is
found on chromosome 4. (provided by RefSeq, Jan 2012)

GeneCards Summary for CXCL1 Gene:
CXCL1 (chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)) is a protein-coding gene. Diseases associated with CXCL1 include alcoholic neuropathy, and tonsillitis. GO annotations related to this gene include chemokine activity and receptor binding. An important paralog of this gene is PPBP.

UniProtKB/Swiss-Prot: GROA_HUMAN, P09341
Function: Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on
endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and
GRO-alpha(6-73) show a 30-fold higher chemotactic activity

Gene Wiki entry for CXCL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CXCL1 gene promoter:
         Bach1   C/EBPbeta   STAT1   AML1a   NF-kappaB2   MyoD   STAT1beta   NF-kappaB1   Evi-1   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXCL1 promoter sequence
   Search Chromatin IP Primers for CXCL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CXCL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3

CXCL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCL1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P074724:  view genomic region     (about GC identifiers)

Start:
74,735,109 bp from pter      End:
74,736,959 bp from pter
Size:
1,851 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GROA_HUMAN, P09341 (See protein sequence)
Recommended Name: Growth-regulated alpha protein precursor  
Size: 107 amino acids; 11301 Da
4 PDB 3D structures from and Proteopedia for CXCL1:
1MGS (3D)        1MSG (3D)        1MSH (3D)        1ROD (3D)    
Secondary accessions: Q9UCR7

Explore the universe of human proteins at neXtProt for CXCL1: NX_P09341

Explore proteomics data for CXCL1 at MOPED

Post-translational modifications: 

  • N-terminal processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) are produced by proteolytic
    cleavage after secretion from peripheral blood monocytes1
  • Modification sites at neXtProt

  • See CXCL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001502.1  
    ENSEMBL proteins: 
     ENSP00000379110  
    Reactome Protein details: P09341

    CXCL1 Human Recombinant Protein Products:

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    R&D Systems Recombinant & Natural Proteins for CXCL1 (CXCL1/GRO alpha/KC/CINC-1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CXCL1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CXCL1
    GenScript Purified and Recombinant Proteins for CXCL1
    Novus Biologicals CXCL1 Proteins
    Novus Biologicals CXCL1 Lysates
    Sino Biological Recombinant Protein for CXCL1
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CXCL1
    Browse Proteins at Cloud-Clone Corp.

    CXCL1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CXCL1 (CXCL1/GRO alpha/KC/CINC-1)
    OriGene Antibodies for CXCL1
    OriGene Custom Antibody Services for CXCL1
    Novus Biologicals CXCL1 Antibodies
    Abcam antibodies for CXCL1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CXCL1
    LSBio Antibodies in human, mouse, rat for CXCL1

    CXCL1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for CXCL1 (CXCL1/GRO alpha/KC/CINC-1)         (see all)
    GenScript Custom Assay Services for CXCL1
    Enzo Life Sciences assays for CXCL1
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    3 InterPro protein domains:
     IPR001811 Chemokine_IL8-like_dom
     IPR001089 Chemokine_CXC
     IPR018048 Chemokine_CXC_CS

    Graphical View of Domain Structure for InterPro Entry P09341

    ProtoNet protein and cluster: P09341

    1 Blocks protein domain: IPB002473 Interleukin-8 signature

    UniProtKB/Swiss-Prot: GROA_HUMAN, P09341
    Similarity: Belongs to the intercrine alpha (chemokine CxC) family


    CXCL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GROA_HUMAN, P09341
    Function: Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on
    endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and
    GRO-alpha(6-73) show a 30-fold higher chemotactic activity

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS10820279
    GO:0008009chemokine activity IEA--
    GO:0008047enzyme activator activity TAS9079638
    GO:0008083growth factor activity IEA--
         
    CXCL1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CXCL1:
     Decreased focal adhesion (FA)   Metaphase cells 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cxcl1):
     cardiovascular system 

    CXCL1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cxcl1tm1Wabo for CXCL1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CXCL1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CXCL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CXCL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CXCL1

    miRNA
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    miRTarBase miRNAs that target CXCL1:
    hsa-mir-1 (MIRT023999), hsa-mir-124-3p (MIRT023084)

    Block miRNA regulation of human, mouse, rat CXCL1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate CXCL1:
    hsa-miR-3163 hsa-miR-607 hsa-miR-873 hsa-miR-641 hsa-miR-539 hsa-miR-3662 hsa-miR-3617
    SwitchGear 3'UTR luciferase reporter plasmidCXCL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CXCL1
    Predesigned siRNA for gene silencing in human, mouse, rat CXCL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CXCL1

    Clone
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    OriGene ORF clones in mouse, rat for CXCL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CXCL1 (NM_001511)
    Sino Biological Human cDNA Clone for CXCL1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CXCL1
    Browse ESI BIO Cell Lines and PureStem Progenitors for CXCL1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GROA_HUMAN, P09341: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    cytoskeleton1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    CXCL1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CXCL1 About   (see all 21)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    IL-6 Pathway0.61
    MIF Mediated Glucocorticoid Regulation0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43
    2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine receptors bind chemokines0.81
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    3Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    4Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.44
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CXCL1
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CXCL1 (see all 17)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    MIF Mediated Glucocorticoid Regulation

    2 GeneGo (Thomson Reuters) Pathways for CXCL1
        Cytokine production by Th17 cells in CF (Mouse model)
    Cytokine production by Th17 cells in CF

    4 BioSystems Pathways for CXCL1
        Cytokines and Inflammatory Response
    Senescence and Autophagy
    Spinal Cord Injury
    IL23-mediated signaling events


    2 Reactome Pathways for CXCL1
        Chemokine receptors bind chemokines
    G alpha (i) signalling events


    Selected Kegg Pathways  (Kegg details for CXCL1) (see all 9):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    NOD-like receptor signaling pathway
    TNF signaling pathway
    Epithelial cell signaling in Helicobacter pylori infection


    CXCL1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CXCL1 (see all 16): 
              Neurogenesis in human mouse rat
              Nephrotoxicity in human mouse rat
              Growth Factors in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Wound Healing in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CXCL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CXCL1 (P093413 ENSP000003791104) via UniProtKB, MINT, STRING, and/or I2D (see all 163)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CXCR2P250253, ENSP000003196354I2D: score=2 STRING: ENSP00000319635
    MMP9P147803, ENSP000003614054I2D: score=1 STRING: ENSP00000361405
    CXCR1P250243, ENSP000002956834I2D: score=2 STRING: ENSP00000295683
    DARCQ165703, ENSP000003571034I2D: score=3 STRING: ENSP00000357103
    HIPK2Q9H2X63I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis TAS10820279
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0007165signal transduction TAS10820279
    GO:0007186G-protein coupled receptor signaling pathway TAS10820279

    CXCL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CXCL1 (GROA)

    Selected Novoseek inferred chemical compound relationships for CXCL1 gene (see all 46)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    groalpha 97.3 249 16510595 (11), 11470861 (9), 9641651 (9), 11495082 (8) (see all 68)
    grogamma 92.2 12 8702798 (4), 9553055 (2), 10695618 (1), 9054580 (1) (see all 7)
    rantes 87.6 132 10881738 (6), 12915769 (5), 12620497 (4), 10464551 (3) (see all 86)
    grobeta 87.4 14 8702798 (4), 16540656 (3), 9553055 (2), 10695618 (1) (see all 7)
    ppbp 72.9 3 7698025 (1), 10343098 (1), 9465307 (1)
    ccl3 68.3 10 17023518 (2), 18565769 (2), 12851650 (1), 19162037 (1) (see all 8)
    tarc 50.7 3 11533168 (1), 15975968 (1), 16316467 (1)
    vegf 36.7 21 18832182 (3), 19176759 (3), 15958549 (2), 17406066 (1) (see all 14)
    sulfapyridine 36.5 2 12231210 (2)
    leukotriene b4 28.4 14 18576322 (5), 18515326 (1), 20008148 (1), 9353042 (1) (see all 6)



    CXCL1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CXCL1 gene: 
    NM_001511.3  

    Unigene Cluster for CXCL1:

    Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
    Hs.789  [show with all ESTs]
    Unigene Representative Sequence: NR_046035
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000509101 ENST00000395761(uc003hhh.2)
    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate CXCL1:
    hsa-miR-3163 hsa-miR-607 hsa-miR-873 hsa-miR-641 hsa-miR-539 hsa-miR-3662 hsa-miR-3617
    SwitchGear 3'UTR luciferase reporter plasmidCXCL1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: CXCL1 (NM_001511)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CXCL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CXCL1
      QuantiTect SYBR Green Assays in human, mouse, rat CXCL1
      QuantiFast Probe-based Assays in human, mouse, rat CXCL1

    Additional mRNA sequence: 

    BC011976.1 BT006880.1 J03561.1 NR_046035.1 X12510.1 

    3 DOTS entries:

    DT.446046  DT.100777292  DT.121241560 

    Selected AceView cDNA sequences (see all 94):

    D82649 CA438155 AI609640 BQ000742 CB140372 AI362592 AA315570 BU626840 
    CB149087 BF000107 BQ021711 BM737792 BM994730 CA307413 NM_001511 X12510 
    BC011976 AW261997 BM984075 AI749188 AI346410 BM771312 BP337762 BG491425 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CXCL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGAAACTTT
    CXCL1 Expression
    About this image


    CXCL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Mesenchymal Stem Cells
             Placenta-derived mesenchymal stem cells (family)
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Monocytes Peripheral Blood
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone marrow-derived mesenchymal stem cells
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
    CXCL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CXCL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.789
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CXCL1 (see all 16): 
              Neurogenesis in human mouse rat
              Nephrotoxicity in human mouse rat
              Growth Factors in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Wound Healing in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CXCL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CXCL1
    QuantiTect SYBR Green Assays in human, mouse, rat CXCL1
    QuantiFast Probe-based Assays in human, mouse, rat CXCL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CXCL1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cxcl15 chemokine (C-X-C motif) ligand 1   --   5 (44.78 cM) 90891241 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    40(a)
    1 → many
    4(50379773-50381069)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    38(a)
    1 → many
    6(60123888-60134622)


    ENSEMBL Gene Tree for CXCL1 (if available)
    TreeFam Gene Tree for CXCL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for CXCL1 gene
    PPBP2  PF42  PF4V12  CXCL62  CXCL32  CXCL52  CXCL22  IL82  
    13 SIMAP similar genes for CXCL1 using alignment to 1 protein entry:     GROA_HUMAN:
    MGSA alpha    CXCL3    CXCL2    PPBP    CXCL5    CXCL6
    CXCL9    PF4    PF4V1    CXCL10    IL8    CXCL11
    CXCL12

    CXCL1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CXCL1
    PGOHUM00000245590


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CXCL1 (see all 177)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1824091421,2
    --74733122(+) AGAAAC/TAATTG 2 -- us2k10--------
    rs1869144671,2
    --74733165(+) GTCTGC/TTTTAA 2 -- us2k10--------
    rs785726271,2
    F--74733296(+) ATTCTG/ATCTTC 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs738288961,2
    C--74733345(+) TATATG/AGTGTT 2 -- us2k12Minor allele frequency- A:0.07WA 120
    rs1924422481,2
    C--74733351(+) GTGTTA/GTATAC 2 -- us2k10--------
    rs1850932331,2
    --74733454(+) ATATAA/TATATA 2 -- us2k10--------
    rs49929781,2
    C--74733474(+) ATATAT/AATATA 2 -- us2k1 tfbs31Minor allele frequency- A:0.00NA 2
    rs68252951,2
    C--74733482(+) atataA/Tatata 2 -- us2k1 tfbs30--------
    rs285761701,2
    C--74733482(+) ATATAT/AATATA 2 -- us2k1 tfbs31Minor allele frequency- A:0.00WA 2
    rs285305141,2
    C--74733555(+) TTTTTA/TTTAAA 2 -- us2k1 trp31Minor allele frequency- T:0.00CSA 1

    HapMap Linkage Disequilibrium report for CXCL1 (74735109 - 74736959 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CXCL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv525980CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CXCL1
    DNA2.0 Custom Variant and Variant Library Synthesis for CXCL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 155730    OMIM disorders: --

    Selected diseases for CXCL1 (see all 96):    
    About MalaCards
    alcoholic neuropathy    tonsillitis    peptic ulcer    melanoma
    yellow fever    adult respiratory distress syndrome    keratitis    duodenal ulcer
    polymyalgia rheumatica    meningitis    h. pylori infection    klebsiella
    bacterial meningitis    endometritis    duodenitis    lymphangioleiomyomatosis
    legionellosis    chronic granulomatous disease    essential thrombocythemia    kaposi's sarcoma

    2 diseases from the University of Copenhagen DISEASES database for CXCL1:
    Melanoma     Lung disease

    CXCL1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CXCL1 gene (see all 58)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 65.4 25 9730682 (1), 10392755 (1), 11371564 (1), 12549928 (1) (see all 23)
    necrosis 58.3 35 9215253 (2), 1744577 (1), 8245503 (1), 9143736 (1) (see all 32)
    melanoma 50.4 46 11406569 (2), 18056965 (2), 11719444 (2), 16098041 (2) (see all 29)
    nasal polyps 47.3 7 16608789 (4), 10889487 (2), 17703097 (1)
    tumors 44.1 68 18451219 (4), 16618733 (3), 19276354 (2), 12427307 (2) (see all 46)
    bronchoalveolar lavage fluid 41.5 4 19155472 (1), 14662873 (1), 7582292 (1)
    rheumatoid arthritis 39.1 6 10437780 (2), 10881738 (2), 9232436 (1), 18576322 (1)
    gastritis 35 1 15557597 (1)
    pneumonia 25.5 1 18345025 (1)
    response acute phase 25.2 1 11916915 (1)

    Genetic Association Database (GAD): CXCL1
    Human Genome Epidemiology (HuGE) Navigator: CXCL1 (8 documents)

    Export disorders for CXCL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CXCL1 gene, integrated from 10 sources (see all 558):
    (articles sorted by number of sources associating them with CXCL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population. (PubMed id 15843053)1, 4, 9 Tamura Y....Hohjoh H. (Neurosci. Lett. 2005)
    2. Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms. (PubMed id 10095777)1, 2, 9 Wuyts A.... Van Damme J. (Eur. J. Biochem. 1999)
    3. Identification of three related human GRO genes encoding cytokine functions. (PubMed id 2217207)1, 3, 9 Haskill S.... Sager R. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    4. Lipopolysaccharide-stimulated human monocytes secrete, apart from neutrophil-activating peptide 1/interleukin 8, a second neutrophil- activating protein. NH2-terminal amino acid sequence identity with melanoma growth stimulatory activity. (PubMed id 2182761)1, 2, 9 Schroeder J.-M.... Christophers E. (J. Exp. Med. 1990)
    5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    6. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    7. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
    8. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)
    9. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2919 HGNC: 4602 AceView: CXCL1 Ensembl:ENSG00000163739 euGenes: HUgn2919
    ECgene: CXCL1 Kegg: 2919 H-InvDB: CXCL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CXCL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CXCL1 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CXCL1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CXCL1 gene:
    Search GeneIP for patents involving CXCL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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