V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

CXCL1 Gene

protein-coding GIFtS: 60

GC04P074974

chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
(Previous names: GRO1 oncogene (melanoma growth stimulating activity, alpha), fibroblast secretory protein )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: MGSA, GRO1, FSP)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FSP ^²
GRO ^³
GRO-alpha(1-73) ^³
GRO1 ^², ³, ⁵
GROA ^³
GROa ^¹, ²
MGSA ^², ³, ⁵
MGSA-a ^¹, ²
NAP-3 ^¹, ², ³
SCYB1 ^¹, ², ³

Descriptions
C-X-C motif chemokine 1 ^³
GRO1 oncogene (melanoma growth stimulating activity, alpha) ^¹, ²
GRO1 oncogene (melanoma growth-stimulating activity) ^²
MGSA alpha ^²
Melanoma growth stimulatory activity ^³
Neutrophil-activating protein 3 ^³
chemokine (C-X-C motif) ligand 1 ^²
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) ^²
fibroblast secretory protein ^¹, ²
melanoma growth stimulatory activity alpha ^²

External Ids
HGNC: 4602¹
Entrez Gene: 2919²
UniProtKB: P09341³
Ensembl: ENSG00000163739⁷

Search outside databases for aliases for CXCL1 gene

Previous GC identifers: GC04P074724 GC04P075135 GC04P075201 GC04P075100

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CXCL1:

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related

molecules that regulate cell trafficking of various types of leukocytes through interactions with

a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles

in the development, homeostasis, and function of the immune system, and they have effects on cells

of the central nervous system as well as on endothelial cells involved in angiogenesis or

angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement

of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single

amino acid in CXC chemokines and are adjacent in CC chemokines. CXC chemokines are further

subdivided into ELR and non-ELR types based on the presence or absence of a glu-leu-arg sequence

adjacent and N terminal to the CXC motif. ELR types are chemotactic for neutrophils, while non-ELR

types are chemotactic for lymphocytes.[supplied by OMIM]

UniProtKB/Swiss-Prot: GROA_HUMAN, P09341

Function: Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its

effects on endothelial cells in an autocrine fashion. In vitro, the processed forms

GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity

Gene Wiki entry for CXCL1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CXCL1 gene

Entrez Gene cytogenetic band: 4q21 Ensembl cytogenetic band: 4q13.3 HGNC cytogenetic band: 4q13.3

CXCL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P074974: (about GC identifiers)

Start:	74,953,973 bp from pter
End:	74,968,249 bp from pter
Size:	14,277 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000004.10 NT_006216.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: GROA_HUMAN, P09341 (See protein sequence)

Recommended Name: Growth-regulated alpha protein precursor

Size: 107 amino acids; 11301 Da

Subcellular location: Secreted

PDB structures from and Proteopedia :

1MGS (3D)

1MSG (3D)

1MSH (3D)

1ROD (3D)

Secondary accessions: Q9UCR7

Post-translational modifications:

N-terminal processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) are produced by

proteolytic cleavage after secretion from peripheral blood monocytes¹

REFSEQ proteins: NP_001502.1

ENSEMBL proteins:

ENSP00000296031

Human Recombinant Proteins

	Invitrogen human recombinant proteins for CXCL1
	Millipore Purified and/or Recombinant CXCL1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for CXCL1 (CXCL1/GRO alpha/KC/CINC-1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GRO alpha)
	Human Recombinant Proteins from Abnova (CXCL1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	TAS	10881932

About this table

Antibodies for CXCL1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for CXCL1
	R&D Systems Antibodies for CXCL1 (CXCL1/GRO alpha/KC/CINC-1)
	Antibodies from Abcam (GRO alpha), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for CXCL1

Assays for CXCL1:

	Invitrogen Assays for CXCL1
	Millipore Kits and Assays for the Analysis of CXCL1
	R&D Systems ELISAs for CXCL1 (CXCL1/GRO alpha/KC/CINC-1) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P09341

ProtoNet protein and cluster: P09341

1 Blocks protein family: IPB002473 Interleukin-8 signature

UniProtKB/Swiss-Prot: GROA_HUMAN, P09341

Similarity: Belongs to the intercrine alpha (chemokine CxC) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CXCL1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CXCL1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001511

Applied Biosystems Silencer® siRNAs for CXCL1

Sigma-Aldrich siRNA and siRNA Panels for CXCL1

Sigma-Aldrich shRNA for CXCL1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CXCL1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001511
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001511
untagged cDNA clones in CMV expression vector (see all 2): NM_001511

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001511

UniProtKB/Swiss-Prot: GROA_HUMAN, P09341

Function: Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its

effects on endothelial cells in an autocrine fashion. In vitro, the processed forms

GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Cxcl1):

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008009	chemokine activity	TAS	10820279
GO:0008047	enzyme activator activity	TAS	9079638
GO:0008083	growth factor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

4 Sigma-Aldrich "Your Favorite Gene" Pathways for CXCL1 (Your Favorite Gene powered by Ingenuity)

Thyroid Cancer Signaling
IL-17 Signaling
IL-8 Signaling
Lymphotoxin &beta

GeneDecks CXCL1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CXCL1

5/75 Interacting proteins for CXCL1 (ENSP00000296031³) via UniProtKB, MINT, and/or STRING (see all 75 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL8RB	ENSP00000319635³	STRING (score=.999)
CADM3	ENSP00000357106³	STRING (score=.986)
IL8RA	ENSP00000295683³	STRING (score=.983)
IL1B	ENSP00000263341³	STRING (score=.982)
IL12B	ENSP00000231228³	STRING (score=.976)

About this table

5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006935	chemotaxis	TAS	10820279
GO:0006954	inflammatory response	TAS	9725262
GO:0006955	immune response	IEA	--
GO:0007186	G-protein coupled receptor protein signaling pathway	TAS	10820279
GO:0007242	intracellular signaling cascade	TAS	9551928

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CXCL1
10/24 Novoseek chemical compound relationships for CXCL1 gene (see all 24 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
groalpha	97.31	233	16510595 (11), 11470861 (9), 9641651 (9), 11495082 (8) (see all 64)
grogamma	92.71	12	8702798 (4), 9553055 (2), 10695618 (1), 9054580 (1) (see all 7)
rantes	87.82	122	10881738 (6), 12915769 (5), 12620497 (4), 10464551 (3) (see all 82)
grobeta	87.07	13	8702798 (4), 16540656 (3), 9553055 (2), 10695618 (1) (see all 6)
ppbp	74.12	3	7698025 (1), 10343098 (1), 9465307 (1)
ccl3	68.67	10	17023518 (2), 18565769 (2), 12851650 (1), 19162037 (1) (see all 8)
tarc	52.56	3	11533168 (1), 15975968 (1), 16316467 (1)
matrigel	28.29	2	15880583 (1), 17583554 (1)
cytochalasin	27.11	1	2182761 (1)
leukotriene b4	24.23	11	18576322 (5), 18515326 (1), 9353042 (1), 7639692 (1) (see all 5)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CXCL1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CXCL1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001511

Sigma-Aldrich siRNA and siRNA Panels for CXCL1

Sigma-Aldrich shRNA for CXCL1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001511

REFSEQ mRNAs for CXCL1 gene:

NM_001511.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001511

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001511
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001511
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001511

Additional cDNA sequence:

BC011976.1 BT006880.1 J03561.1 X12510.1

3 DOTS entries:

DT.446046 DT.100777292 DT.121241560

24/94 AceView cDNA sequences (see all 94 ):

D82649 BU626840 CA307413 BQ000742 BQ021711 AW261997 AA315570 BC011976

CA438155 CB149087 AI362592 CB140372 X12510 BM737792 AI609640 BM994730

NM_001511 BF000107 BM984075 BM771312 BM762272 AW081601 J03561 BF437778

highest scoring ESTs for CXCL1:

AA054552 AA315570 AA381180 AA469039 AA530972 AA594627 AA627560 AA627993 AA936997 AI148274

Unigene Cluster for CXCL1:

Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)

Hs.789 [show with all ESTs]

Unigene Representative Sequence: BF032655

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000296031

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CXCL1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CXCL1

¹ / ² / ³

3 probe-sets matching CXCL1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
408_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X54489	0.20	1.00	0.72	1
204470_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001511	0.60	1.00	0.82	1
204470_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CXCL1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTGAAACTTT

SOURCE GeneReport for Unigene cluster: Hs.789

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CXCL1 gene from 3 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	CXCL1¹	--	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating more	98.75(n) 100(a)	740567 XM_001156094.1 XP_001156094.1
rat (Rattus norvegicus)	Cxcl3¹	--	chemokine (C-X-C motif) ligand 3	69.12(n) 58.95(a)	171551 NM_138522.1 NP_612531.1
mouse (Mus musculus)	Cxcl1⁵ Cxcl3¹	5 (51.00 cM)⁵	chemokine (C-X-C motif) ligand 1⁵ chemokine (C-X-C motif) ligand 3¹	70.03(n)¹ 57.58(a)¹	330122¹ NM_203320.2¹ NP_976065.1¹ AK140312⁵ BC037997⁵ (see all 15)

About this table Species with no ortholog for CXCL1

ENSEMBL Gene Tree for CXCL1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CXCL1 gene

PF4² PPBP² PF4V1² CXCL6² CXCL3² CXCL5² CXCL2² IL8²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/37 NCBI SNPs in CXCL1 are shown (see all 37 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 57)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3117604^1,2	A,C,F,H	74953532(+)	`CTCAAC/TCTCCA`	1	--	ng5¹ tfbs³		4		EU EA WA	412
--	rs4992978^1,2	C	74952338(+)	`atataA/Tatata`	1	--	ng5¹ tfbs³		0	--	--	--	--
	rs2071425^1,2	A,C,F	74954108(+)	`GTGGCA/GCTGCT`	1	A/A	syn¹ ese³		2		EA NA	1356
	rs4074^1,2	A,C,F,H	74955008(+)	`TCGGAG/AAACTC`	1	--	int¹		9		EA MN EU WA NA	2440
--	rs1814092^1,2	F	74955099(+)	`CATTGC/TAGTGA`	1	--	int¹		3		EA NA	62
--	rs2018732^1,2	F	74954598(+)	`ACAGGC/TGACTG`	1	--	int¹		1		NA	65
--	rs66791180^1,2	--	74952338(+)	`ATATA-/TAT ATATATATAT`	1	--	ng5¹		0	--	--	--	--
--	rs72078290^1,2	--	74952309(+)	`ATATA-/ATA TATATTATAT`	1	--	ng5¹		0	--	--	--	--
	rs28530514^1,2	--	74952419(+)	`TTTTTA/TTTAAA`	1	--	ng5¹ trp³		0	--	--	--	--
--	rs34849214^1,2	--	74955217(+)	`CACCT-/GGGATT`	1	--	ut3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for CXCL1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 155730

10/57 Novoseek disease relationships for CXCL1 gene (see all 57 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	64.48	23	9730682 (1), 10392755 (1), 11371564 (1), 12549928 (1) (see all 21)
necrosis	56.44	33	9215253 (2), 1744577 (1), 8245503 (1), 9143736 (1) (see all 30)
melanoma	50.85	45	11406569 (2), 18056965 (2), 11719444 (2), 16098041 (2) (see all 28)
nasal polyps	49.47	7	16608789 (4), 10889487 (2), 17703097 (1)
tumors	42.51	67	18451219 (4), 16618733 (3), 19276354 (2), 12427307 (2) (see all 45)
gastritis	36.57	1	15557597 (1)
rheumatoid arthritis	35.24	6	10437780 (2), 10881738 (2), 9232436 (1), 18576322 (1)
bronchoalveolar lavage fluid	31.58	4	19155472 (1), 14662873 (1), 7582292 (1)
inflammatory bowel diseases	25.01	2	11495082 (1), 18956592 (1)
pneumonia	21.79	1	18345025 (1)

About this table

Genetic Association Database: CXCL1
Human Genome Epidemiology Navigator: CXCL1 (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/465 PubMed articles for CXCL1 gene (see all 465 ):

Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population. (PubMed id 15843053)^{1, 3, 6} Tamura Y....Hohjoh H. (2005)
Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms. (PubMed id 10095777)^{1, 3, 4} Wuyts A.... Van Damme J. (1999)
Identification of three related human GRO genes encoding cytokine functions. (PubMed id 2217207)^{1, 2, 3} Haskill S.... Sager R. (1990)
Lipopolysaccharide-stimulated human monocytes secrete, apart from neutrophil-activating peptide 1/interleukin 8, a second neutrophil- activating protein. NH2-terminal amino acid sequence identity with melanoma growth stimulatory activity. (PubMed id 2182761)^{1, 3, 4} Schroeder J.-M.... Christophers E. (1990)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{3, 4} Zhang Z. and Henzel W.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The solution structure of melanoma growth stimulating activity. (PubMed id 8089846)^{3, 4} Fairbrother W.J.... Horuk R. (1994)
Solution structure of GRO/melanoma growth stimulatory activity determined by 1H NMR spectroscopy. (PubMed id 7806518)^{3, 4} Kim K.S.... Sykes B.D. (1994)
1H assignment and secondary structure determination of human melanoma growth stimulating activity (MGSA) by NMR spectroscopy. (PubMed id 8397104)^{3, 4} Fairbrother W.J.... Horuk R. (1993)
Nucleotide sequence of the human melanoma growth stimulatory activity (MGSA) gene. (PubMed id 2129556)^{3, 4} Baker N.E.... Richmond A. (1990)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2919	HGNC: 4602	AceView: CXCL1	Ensembl:ENSG00000163739	euGenes: HUgn2919
ECgene: CXCL1	H-InvDB: CXCL1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CXCL1	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/CXCL1

Licensable Technologies for CXCL1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CXCL1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CXCL1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CXCL1		Antibodies for CXCL1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CXCL1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CXCL1)
	Search for Antibodies
	Chimera RNAi (CXCL1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (GRO alpha)
	Antibodies (GRO alpha)

Search OriGene for CXCL1

Search Tocris compounds for CXCL1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CXCL1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CXCL1 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

CXCL1 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for CXCL1

Summaries
for CXCL1

Genomic Location
for CXCL1

Proteins
for CXCL1

Protein Domains/
Families
for CXCL1

Gene Function
for CXCL1

Pathways & Interactions
for CXCL1

Drugs & Compounds
for CXCL1

Transcripts
for CXCL1

Expression
for CXCL1

Orthologs
for CXCL1

Paralogs
for CXCL1

SNPs/Variants
for CXCL1

Disorders & Mutations
for CXCL1

Medical News
for CXCL1

Publications
for CXCL1

Search for CXCL1

Genome Databases showing CXCL1

Other Databases showing CXCL1

Specialized Databases showing CXCL1

Licensable Technologies
for CXCL1

Services
for CXCL1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CXCL1 (Gene Symbol)
FSP
GRO
GRO-alpha(1-73)
GRO1
GROA
GROa
MGSA
MGSA-a
NAP-3
SCYB1
C-X-C motif chemokine 1
GRO1 oncogene (melanoma growth stimulating activity, alpha)
GRO1 oncogene (melanoma growth-stimulating activity)
MGSA alpha
Melanoma growth stimulatory activity
Neutrophil-activating protein 3
chemokine (C-X-C motif) ligand 1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
fibroblast secretory protein
melanoma growth stimulatory activity alpha

CXCL1 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor CXCL1

Summariesfor CXCL1

Genomic Locationfor CXCL1

Proteinsfor CXCL1

Protein Domains/Familiesfor CXCL1

Gene Functionfor CXCL1

Pathways & Interactionsfor CXCL1

Drugs & Compoundsfor CXCL1

Transcriptsfor CXCL1

Expression for CXCL1

Orthologsfor CXCL1

Paralogsfor CXCL1

SNPs/Variantsfor CXCL1

Disorders & Mutationsfor CXCL1

Medical Newsfor CXCL1

Publicationsfor CXCL1

Search for CXCL1

Genome Databases showing CXCL1

Other Databases showing CXCL1

Specialized Databases showing CXCL1

Licensable Technologiesfor CXCL1

Servicesfor CXCL1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CXCL1

Summaries
for CXCL1

Genomic Location
for CXCL1

Proteins
for CXCL1

Protein Domains/
Families
for CXCL1

Gene Function
for CXCL1

Pathways & Interactions
for CXCL1

Drugs & Compounds
for CXCL1

Transcripts
for CXCL1

Expression
for CXCL1

Orthologs
for CXCL1

Paralogs
for CXCL1

SNPs/Variants
for CXCL1

Disorders & Mutations
for CXCL1

Medical News
for CXCL1

Publications
for CXCL1

Licensable Technologies
for CXCL1

Services
for CXCL1