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Aliases for CXADR Gene

Aliases for CXADR Gene

  • Coxsackie Virus And Adenovirus Receptor 2 3
  • CAR 3 4 6
  • Coxsackievirus B-Adenovirus Receptor 3 4
  • CVB3-Binding Protein 3 4
  • HCVADR 3 4
  • HCAR 3 4
  • 46 KD Coxsackievirus And Adenovirus Receptor (CAR) Protein 3
  • Coxsackievirus And Adenovirus Receptor 3
  • CAR4/6 3

External Ids for CXADR Gene

Previous GeneCards Identifiers for CXADR Gene

  • GC21P015549
  • GC21P017807
  • GC21P018884
  • GC21P004271

Summaries for CXADR Gene

Entrez Gene Summary for CXADR Gene

  • The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. [provided by RefSeq, May 2011]

GeneCards Summary for CXADR Gene

CXADR (Coxsackie Virus And Adenovirus Receptor) is a Protein Coding gene. Diseases associated with CXADR include hypocalcemia, autosomal dominant and familial hypocalciuric hypercalcemia. Among its related pathways are Class I MHC mediated antigen processing and presentation and Hemostasis. GO annotations related to this gene include identical protein binding and PDZ domain binding. An important paralog of this gene is VSIG8.

UniProtKB/Swiss-Prot for CXADR Gene

  • Component of the epithelial apical junction complex that may function as an homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with AMICA1/JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.

Gene Wiki entry for CXADR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXADR Gene

Genomics for CXADR Gene

Regulatory Elements for CXADR Gene

Genomic Location for CXADR Gene

Start:
17,512,382 bp from pter
End:
17,593,579 bp from pter
Size:
81,198 bases
Orientation:
Plus strand

Genomic View for CXADR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CXADR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXADR Gene

Proteins for CXADR Gene

  • Protein details for CXADR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78310-CXAR_HUMAN
    Recommended name:
    Coxsackievirus and adenovirus receptor
    Protein Accession:
    P78310
    Secondary Accessions:
    • B2R8V8
    • B7WPI3
    • D3YHP0
    • O00694
    • Q8WWT6
    • Q8WWT7
    • Q8WWT8
    • Q9UKV4

    Protein attributes for CXADR Gene

    Size:
    365 amino acids
    Molecular mass:
    40030 Da
    Quaternary structure:
    • Monomer. May form homodimer. Interacts with LNX, BAIAP1, DLG4, PRKCABP, TJP1 and CTNNB1. Interacts with MPDZ; recruits MPDZ to intercellular contact sites. Interacts with AMICA1 (homodimeric form). Secreted isoform 3, isoform 4 and isoform 5 can interact with the extracellular domain of the receptor. Interacts with adenovirus subgroups A, C, D, E and F fiber proteins as well as coxsackievirus B1, B2, B3, B4, B5 and B6 capsid proteins and acts as a receptor for these viruses.

    Three dimensional structures from OCA and Proteopedia for CXADR Gene

    Alternative splice isoforms for CXADR Gene

neXtProt entry for CXADR Gene

Proteomics data for CXADR Gene at MOPED

Post-translational modifications for CXADR Gene

Other Protein References for CXADR Gene

No data available for DME Specific Peptides for CXADR Gene

Domains for CXADR Gene

Gene Families for CXADR Gene

HGNC:
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for CXADR Gene

Suggested Antigen Peptide Sequences for CXADR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P78310

UniProtKB/Swiss-Prot:

CXAR_HUMAN :
  • P78310
Domain:
  • The Ig-like C2-type 1 domain mediates homodimerization and interaction with AMICA1
  • The PDZ-binding motif mediates interaction with MPDZ and BAIAP1
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with CXADR: view

Function for CXADR Gene

Molecular function for CXADR Gene

GENATLAS Biochemistry: coxsackie B and adenovirus (group C) common receptor
UniProtKB/Swiss-Prot Function: Component of the epithelial apical junction complex that may function as an homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with AMICA1/JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.

Gene Ontology (GO) - Molecular Function for CXADR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005102 receptor binding IPI 14978041
GO:0005178 integrin binding IPI 12869515
GO:0005515 protein binding IPI 11734628
GO:0008013 beta-catenin binding IPI 12297051
genes like me logo Genes that share ontologies with CXADR: view
genes like me logo Genes that share phenotypes with CXADR: view

Animal Models for CXADR Gene

MGI Knock Outs for CXADR:

miRNA for CXADR Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CXADR Gene

Localization for CXADR Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXADR Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Cell junction, adherens junction. Basolateral cell membrane; Single-pass type I membrane protein. Note=In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions. In airway epithelial cells localized to basolateral membrane but not to apical surface.
Isoform 2: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Cell junction, adherens junction. Basolateral cell membrane; Single-pass membrane protein. Note=In epithelial cells localizes to the apical junction complex composced of tight and adherens junctions. In airway epithelial cells localized to basolateral membrane but not to apical surface.
Isoform 3: Secreted.
Isoform 4: Secreted.
Isoform 5: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CXADR Gene COMPARTMENTS Subcellular localization image for CXADR gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CXADR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle ISS --
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 14978041
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with CXADR: view

Pathways for CXADR Gene

genes like me logo Genes that share pathways with CXADR: view

Gene Ontology (GO) - Biological Process for CXADR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007005 mitochondrion organization ISS --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA 12869515
GO:0007507 heart development ISS --
GO:0007596 blood coagulation TAS --
GO:0008354 germ cell migration ISS --
genes like me logo Genes that share ontologies with CXADR: view

Compounds for CXADR Gene

(46) Novoseek inferred chemical compound relationships for CXADR Gene

Compound -log(P) Hits PubMed IDs
penton 86.4 8
androstane 83.6 8
citco 82.7 4
cinacalcet 69.5 7
depsipeptide 68 19
genes like me logo Genes that share compounds with CXADR: view

Transcripts for CXADR Gene

Unigene Clusters for CXADR Gene

Coxsackie virus and adenovirus receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CXADR Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: -
SP2: - - -
SP3: - - - - -
SP4: - - - -
SP5:

Relevant External Links for CXADR Gene

GeneLoc Exon Structure for
CXADR
ECgene alternative splicing isoforms for
CXADR

Expression for CXADR Gene

mRNA expression in normal human tissues for CXADR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CXADR Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CXADR Gene

SOURCE GeneReport for Unigene cluster for CXADR Gene Hs.627078

mRNA Expression by UniProt/SwissProt for CXADR Gene

P78310-CXAR_HUMAN
Tissue specificity: Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy.
genes like me logo Genes that share expressions with CXADR: view

Orthologs for CXADR Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXADR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXADR 35
  • 98.74 (n)
  • 99.13 (a)
CXADR 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CXADR 35
  • 88.64 (n)
  • 91.55 (a)
CXADR 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CXADR 35
  • 91.74 (n)
  • 91.17 (a)
CXADR 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cxadr 35
  • 83.56 (n)
  • 89.86 (a)
Cxadr 16
Cxadr 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CXADR 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CXADR 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cxadr 35
  • 84.66 (n)
  • 90.56 (a)
chicken
(Gallus gallus)
Aves CXADR 35
  • 67.31 (n)
  • 61.98 (a)
CXADR 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CXADR 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cxadr 35
  • 60.98 (n)
  • 61.38 (a)
Str.2704 35
zebrafish
(Danio rerio)
Actinopterygii cxadr 35
cxadr 35
  • 57.37 (n)
  • 51.38 (a)
cxadr 36
  • 50 (a)
OneToOne
Species with no ortholog for CXADR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXADR Gene

ENSEMBL:
Gene Tree for CXADR (if available)
TreeFam:
Gene Tree for CXADR (if available)

Paralogs for CXADR Gene

Paralogs for CXADR Gene

Selected SIMAP similar genes for CXADR Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CXADR Gene

genes like me logo Genes that share paralogs with CXADR: view

Variants for CXADR Gene

Sequence variations from dbSNP and Humsavar for CXADR Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs12034 -- 17,569,905(-) TTTTC(C/T)TCAGT utr-variant-3-prime, intron-variant
rs169836 -- 17,521,053(-) CTTTA(C/T)ACAGA intron-variant
rs177032 -- 17,577,432(-) AATAA(A/G)AAAAT intron-variant
rs177033 -- 17,577,605(-) TTGCA(A/G)AATGG intron-variant
rs182415 -- 17,520,779(-) CAGAC(A/G)TCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CXADR Gene

Variant ID Type Subtype PubMed ID
esv2723192 CNV Deletion 23290073
dgv4684n71 CNV Gain 21882294
esv994798 CNV Loss 20482838

Relevant External Links for CXADR Gene

HapMap Linkage Disequilibrium report
CXADR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXADR Gene

Disorders for CXADR Gene

(1) University of Copenhagen DISEASES for CXADR Gene

(79) Novoseek inferred disease relationships for CXADR Gene

Disease -log(P) Hits PubMed IDs
adenovirus infections 84.2 21
nshpt 74.1 6
coxsackie virus 66.9 8
hyperparathyroidism secondary 57.4 3
hypocalcemia, autosomal dominant 57 3

Relevant External Links for CXADR

Genetic Association Database (GAD)
CXADR
Human Genome Epidemiology (HuGE) Navigator
CXADR
genes like me logo Genes that share disorders with CXADR: view

No data available for UniProtKB/Swiss-Prot for CXADR Gene

Publications for CXADR Gene

  1. Fatty acid modification of the coxsackievirus and adenovirus receptor. (PMID: 12021372) van't Hof W. … Crystal R.G. (J. Virol. 2002) 3 4 23
  2. Expression of Coxsackie-adenovirus-receptor and alpha v-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers. (PMID: 10490761) Fechner H. … Poller W. (Gene Ther. 1999) 3 4 23
  3. The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction. (PMID: 11734628) Cohen C.J. … Bergelson J.M. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4 23
  4. Alternatively spliced soluble coxsackie-adenovirus receptors inhibit coxsackievirus infection. (PMID: 14978041) Doerner A. … Knowlton K.U. (J. Biol. Chem. 2004) 3 4 23
  5. A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth. (PMID: 15304526) Ashbourne-Excoffon K.J.D. … Zabner J. (J. Cell Sci. 2004) 3 4 23

Products for CXADR Gene

Sources for CXADR Gene

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