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Aliases for CXADR Gene

Aliases for CXADR Gene

  • Coxsackie Virus And Adenovirus Receptor 2 3 5
  • Coxsackievirus B-Adenovirus Receptor 3 4
  • CVB3-Binding Protein 3 4
  • HCVADR 3 4
  • HCAR 3 4
  • CAR 3 4
  • 46 KD Coxsackievirus And Adenovirus Receptor (CAR) Protein 3
  • Coxsackievirus And Adenovirus Receptor 3
  • CAR4/6 3

External Ids for CXADR Gene

Previous GeneCards Identifiers for CXADR Gene

  • GC21P015549
  • GC21P017807
  • GC21P018884
  • GC21P004271

Summaries for CXADR Gene

Entrez Gene Summary for CXADR Gene

  • The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. [provided by RefSeq, May 2011]

GeneCards Summary for CXADR Gene

CXADR (Coxsackie Virus And Adenovirus Receptor) is a Protein Coding gene. Diseases associated with CXADR include Myocarditis and Dilated Cardiomyopathy. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Immune System. GO annotations related to this gene include identical protein binding and integrin binding. An important paralog of this gene is ENSG00000277666.

UniProtKB/Swiss-Prot for CXADR Gene

  • Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.

  • (Microbial infection) Acts as a receptor for adenovirus type C (PubMed:9733828, PubMed:10666333, PubMed:12297051, PubMed:10567268). Acts as a receptor for Coxsackievirus B1 to B6 (PubMed:14978041, PubMed:10814575).

Gene Wiki entry for CXADR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXADR Gene

Genomics for CXADR Gene

Regulatory Elements for CXADR Gene

Enhancers for CXADR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21F017491 0.5 Ensembl ENCODE 12.5 -20.1 -20078 1.8 STAT1 JUN EP300 JUND ATF3 STAT3 FOS NFE2 NFE2L2 CXADR LINC01549 RPL39P40 TRG-GCC1-5
GH21F017489 0.7 ENCODE 11.9 -22.5 -22535 0.9 JUN CEBPA CEBPG MNT CXADR LINC01549 RPL39P40 TRG-GCC1-5
GH21F017440 0.2 ENCODE 6.1 -70.7 -70659 1.5 TBP RAD21 CREM THAP11 CEBPB KAT8 TGIF2 ATF4 RCOR2 CEBPA CXADR LINC01549 TRG-GCC1-5
GH21F017547 0.3 FANTOM5 2.2 +35.4 35395 0.3 LINC01549 CXADR ENSG00000200754 GC21M017529 GC21P017568
GH21F017510 0.8 Ensembl ENCODE 0.8 +0.7 677 4.5 ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 GTF3C2 ZNF121 GLIS2 ELK1 RPL39P40 ENSG00000228798 CXADR BTF3L4P1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CXADR on UCSC Golden Path with GeneCards custom track

Promoters for CXADR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000611733 918 3001 ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 GLIS2 ELK1 SP3 SP5

Genomic Location for CXADR Gene

Chromosome:
21
Start:
17,512,382 bp from pter
End:
17,633,323 bp from pter
Size:
120,942 bases
Orientation:
Plus strand

Genomic View for CXADR Gene

Genes around CXADR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXADR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXADR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXADR Gene

Proteins for CXADR Gene

  • Protein details for CXADR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78310-CXAR_HUMAN
    Recommended name:
    Coxsackievirus and adenovirus receptor
    Protein Accession:
    P78310
    Secondary Accessions:
    • B2R8V8
    • B7WPI3
    • D3YHP0
    • O00694
    • Q8WWT6
    • Q8WWT7
    • Q8WWT8
    • Q9UKV4

    Protein attributes for CXADR Gene

    Size:
    365 amino acids
    Molecular mass:
    40030 Da
    Quaternary structure:
    • Monomer. May form homodimer. Interacts with LNX, BAIAP1, DLG4, PRKCABP, TJP1 and CTNNB1. Interacts with MPDZ; recruits MPDZ to intercellular contact sites. Interacts with JAML (homodimeric form). Secreted isoform 3, isoform 4 and isoform 5 can interact with the extracellular domain of the receptor.
    • (Microbial infection) Interacts with adenovirus subgroups A, C, D, E and F fiber proteins as well as coxsackievirus B1, B2, B3, B4, B5 and B6 capsid proteins (PubMed:14978041, PubMed:9733828, PubMed:10666333, PubMed:10814575, PubMed:12297051, PubMed:10567268).

    Three dimensional structures from OCA and Proteopedia for CXADR Gene

    Alternative splice isoforms for CXADR Gene

neXtProt entry for CXADR Gene

Post-translational modifications for CXADR Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CXADR (CXADR)
  • Cloud-Clone Corp. Antibodies for CXADR

No data available for DME Specific Peptides for CXADR Gene

Domains & Families for CXADR Gene

Suggested Antigen Peptide Sequences for CXADR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P78310

UniProtKB/Swiss-Prot:

CXAR_HUMAN :
  • The Ig-like C2-type 1 domain mediates homodimerization and interaction with JAML.
Domain:
  • The Ig-like C2-type 1 domain mediates homodimerization and interaction with JAML.
  • The PDZ-binding motif mediates interaction with MPDZ and BAIAP1.
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with CXADR: view

Function for CXADR Gene

Molecular function for CXADR Gene

GENATLAS Biochemistry:
coxsackie B and adenovirus (group C) common receptor
UniProtKB/Swiss-Prot Function:
Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for adenovirus type C (PubMed:9733828, PubMed:10666333, PubMed:12297051, PubMed:10567268). Acts as a receptor for Coxsackievirus B1 to B6 (PubMed:14978041, PubMed:10814575).

Gene Ontology (GO) - Molecular Function for CXADR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005178 integrin binding IPI 12869515
GO:0005515 protein binding IPI 11734628
GO:0008013 beta-catenin binding IPI 12297051
GO:0030165 PDZ domain binding IPI 15364909
genes like me logo Genes that share ontologies with CXADR: view
genes like me logo Genes that share phenotypes with CXADR: view

Animal Models for CXADR Gene

MGI Knock Outs for CXADR:

Animal Model Products

miRNA for CXADR Gene

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CXADR Gene

Localization for CXADR Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXADR Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Cell junction, adherens junction. Note=In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions (PubMed:12297051). In airway epithelial cells localized to basolateral membrane but not to apical surface (PubMed:11316797). {ECO:0000269 PubMed:11316797, ECO:0000269 PubMed:12297051}.
Isoform 3: Secreted.
Isoform 4: Secreted.
Isoform 5: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CXADR Gene COMPARTMENTS Subcellular localization image for CXADR gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CXADR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle ISS --
GO:0005576 extracellular region IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 22003382
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with CXADR: view

Pathways & Interactions for CXADR Gene

genes like me logo Genes that share pathways with CXADR: view

Pathways by source for CXADR Gene

Gene Ontology (GO) - Biological Process for CXADR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007005 mitochondrion organization ISS --
GO:0007155 cell adhesion IEA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA 12869515
GO:0007507 heart development ISS --
GO:0008354 germ cell migration ISS --
genes like me logo Genes that share ontologies with CXADR: view

No data available for SIGNOR curated interactions for CXADR Gene

Drugs & Compounds for CXADR Gene

(29) Drugs for CXADR Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CMX001 Investigational Pharma Broad spectrum antiviral drug 0

(18) Additional Compounds for CXADR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for CXADR Gene

Compound Action Cas Number
CMX001 Broad spectrum antiviral drug 444805-28-1
genes like me logo Genes that share compounds with CXADR: view

Transcripts for CXADR Gene

Unigene Clusters for CXADR Gene

Coxsackie virus and adenovirus receptor:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXADR Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: -
SP2: - - -
SP3: - - - - -
SP4: - - - -
SP5:

Relevant External Links for CXADR Gene

GeneLoc Exon Structure for
CXADR
ECgene alternative splicing isoforms for
CXADR

Expression for CXADR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CXADR Gene

mRNA differential expression in normal tissues according to GTEx for CXADR Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x4.5).

Protein differential expression in normal tissues from HIPED for CXADR Gene

This gene is overexpressed in Fetal Brain (31.3) and Nasal epithelium (28.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CXADR Gene



NURSA nuclear receptor signaling pathways regulating expression of CXADR Gene:

CXADR

SOURCE GeneReport for Unigene cluster for CXADR Gene:

Hs.627078

mRNA Expression by UniProt/SwissProt for CXADR Gene:

P78310-CXAR_HUMAN
Tissue specificity: Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy.
genes like me logo Genes that share expression patterns with CXADR: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for CXADR Gene

Orthologs for CXADR Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXADR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXADR 34 35
  • 98.74 (n)
dog
(Canis familiaris)
Mammalia CXADR 34 35
  • 91.74 (n)
cow
(Bos Taurus)
Mammalia CXADR 34 35
  • 88.64 (n)
rat
(Rattus norvegicus)
Mammalia Cxadr 34
  • 84.66 (n)
mouse
(Mus musculus)
Mammalia Cxadr 34 16 35
  • 83.56 (n)
oppossum
(Monodelphis domestica)
Mammalia CXADR 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CXADR 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves CXADR 34 35
  • 67.31 (n)
lizard
(Anolis carolinensis)
Reptilia CXADR 35
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cxadr 34
  • 60.98 (n)
Str.2704 34
zebrafish
(Danio rerio)
Actinopterygii cxadr 34 34 35
  • 57.37 (n)
Species where no ortholog for CXADR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXADR Gene

ENSEMBL:
Gene Tree for CXADR (if available)
TreeFam:
Gene Tree for CXADR (if available)

Paralogs for CXADR Gene

(3) SIMAP similar genes for CXADR Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CXADR: view

Variants for CXADR Gene

Sequence variations from dbSNP and Humsavar for CXADR Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs10084580 -- 17,533,041(+) GAGGA(A/G)AAGAA intron-variant
rs10084613 -- 17,628,596(+) cccag(G/T)ttcaa intron-variant
rs10222108 -- 17,517,680(+) ATAAA(A/C)AGTTG intron-variant
rs1047729 -- 17,567,491(+) GAGGT(G/T)AAGGT intron-variant, utr-variant-3-prime
rs10482887 -- 17,559,164(+) CATGC(C/T)ATTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CXADR Gene

Variant ID Type Subtype PubMed ID
dgv4391n100 CNV gain 25217958
esv2723192 CNV deletion 23290073
esv3575381 CNV gain 25503493
esv3646482 CNV loss 21293372
esv3893382 CNV gain 25118596
esv994798 CNV loss 20482838
nsv1071746 CNV deletion 25765185
nsv1077779 OTHER inversion 25765185
nsv1123537 CNV deletion 24896259
nsv1127878 CNV deletion 24896259
nsv1133074 OTHER inversion 24896259
nsv1136602 CNV deletion 24896259
nsv1153177 OTHER inversion 26484159
nsv962669 CNV duplication 23825009
nsv964486 CNV duplication 23825009
nsv966035 CNV duplication 23825009
nsv979525 CNV duplication 23825009

Variation tolerance for CXADR Gene

Residual Variation Intolerance Score: 45.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.22; 40.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CXADR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXADR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXADR Gene

Disorders for CXADR Gene

MalaCards: The human disease database

(6) MalaCards diseases for CXADR Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
myocarditis
  • myocardial inflammation
dilated cardiomyopathy
  • congestive cardiomyopathy
hyperparathyroidism, neonatal
  • hyperparathyroidism, neonatal severe
familial hypocalciuric hypercalcemia
  • familial benign hypercalcemia
snowflake vitreoretinal degeneration
  • vitreoretinal degeneration, snowflake type
- elite association - COSMIC cancer census association via MalaCards
Search CXADR in MalaCards View complete list of genes associated with diseases

Relevant External Links for CXADR

Genetic Association Database (GAD)
CXADR
Human Genome Epidemiology (HuGE) Navigator
CXADR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CXADR
genes like me logo Genes that share disorders with CXADR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXADR Gene

Publications for CXADR Gene

  1. Alternatively spliced soluble coxsackie-adenovirus receptors inhibit coxsackievirus infection. (PMID: 14978041) Doerner A. … Knowlton K.U. (J. Biol. Chem. 2004) 3 4 22 64
  2. A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth. (PMID: 15304526) Ashbourne-Excoffon K.J.D. … Zabner J. (J. Cell Sci. 2004) 3 4 22 64
  3. Isoform-specific expression of the Coxsackie and adenovirus receptor (CAR) in neuromuscular junction and cardiac intercalated discs. (PMID: 15533241) Shaw C.A. … Nalbantoglu J. (BMC Cell Biol. 2004) 3 4 22 64
  4. Fatty acid modification of the coxsackievirus and adenovirus receptor. (PMID: 12021372) van't Hof W. … Crystal R.G. (J. Virol. 2002) 3 4 22 64
  5. Human coxsackie-adenovirus receptor is colocalized with integrins alpha(v)beta(3) and alpha(v)beta(5) on the cardiomyocyte sarcolemma and upregulated in dilated cardiomyopathy: implications for cardiotropic viral infections. (PMID: 11457744) Noutsias M. … Poller W. (Circulation 2001) 3 4 22 64

Products for CXADR Gene

Sources for CXADR Gene

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