Aliases for CXADR Gene
External Ids for CXADR Gene
Previous GeneCards Identifiers for CXADR Gene
The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. [provided by RefSeq, May 2011]
GeneCards Summary for CXADR Gene
CXADR (Coxsackie Virus And Adenovirus Receptor) is a Protein Coding gene. Diseases associated with CXADR include hyperparathyroidism, neonatal and familial hypocalciuric hypercalcemia. Among its related pathways are Immune System and Hemostasis. GO annotations related to this gene include identical protein binding and integrin binding. An important paralog of this gene is VSIG8.
UniProtKB/Swiss-Prot for CXADR Gene
Component of the epithelial apical junction complex that may function as an homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with AMICA1/JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.
(Microbial infection) Acts as a receptor for adenovirus type C (PubMed:9733828, PubMed:10666333, PubMed:12297051, PubMed:10567268). Acts as a receptor for Coxsackievirus B1 to B6 (PubMed:14978041, PubMed:10814575).