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CXADR Gene

protein-coding   GIFtS: 68
GCID: GC21P018884

Coxsackie Virus And Adenovirus Receptor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
Coxsackie Virus And Adenovirus Receptor1 2     CVB3-Binding Protein2 3
CAR2 3 5     CAR4/62
46 KD Coxsackievirus And Adenovirus Receptor (CAR) Protein2 11     HCAR2
Coxsackievirus B-Adenovirus Receptor2 3     Coxsackievirus And Adenovirus Receptor2
HCVADR2 3     hCAR3

External Ids:    HGNC: 25591   Entrez Gene: 15252   Ensembl: ENSG000001546397   OMIM: 6026215   UniProtKB: P783103   

Export aliases for CXADR gene to outside databases

Previous GC identifers: GC21P015549 GC21P017807 GC21P004271


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CXADR Gene:
The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C
adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes
of this gene are found on chromosomes 15, 18, and 21. (provided by RefSeq, May 2011)

GeneCards Summary for CXADR Gene:
CXADR (coxsackie virus and adenovirus receptor) is a protein-coding gene. Diseases associated with CXADR include familial hypocalciuric hypercalcemia, and hyperparathyroidism. GO annotations related to this gene include PDZ domain binding and identical protein binding. An important paralog of this gene is CLMP.

UniProtKB/Swiss-Prot: CXAR_HUMAN, P78310
Function: Component of the epithelial apical junction complex that may function as an homophilic cell adhesion
molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes
through adhesive interactions with AMICA1/JAML a transmembrane protein of the plasma membrane of leukocytes. The
interaction between both receptors also mediates the activation of gamma-delta T cells, a subpopulation of T
cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1
induces downstream cell signaling events in gamma-delta T cells through PI3-kinase and MAP kinases. It results in
proliferation and production of cytokines and growth factors by T cells that in turn stimulate epithelial tissues
repair

Gene Wiki entry for CXADR (Coxsackie virus and adenovirus receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence:
NC_000021.9  NC_018932.2  NT_011512.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the CXADR gene promoter:
         c-Fos   AP-1   JunB   Fra-1   FosB   LCR-F1   JunD   FOXJ2 (long isoform)   FOXJ2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXADR promoter sequence

   Search Chromatin IP Primers for CXADR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CXADR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q21.1   Ensembl cytogenetic band:  21q21.1   HGNC cytogenetic band: 21q21.1
Nature(405: 311-319) cytogenetic band:   21q21.1
CXADR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXADR gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P018884:   GeneLoc Nature:405,311-319
Start:
18,884,700 bp from pter       4,549,799 bp from centromere
End:
18,965,897 bp from pter 4,603,690 bp from centromere
Size:
81,198 bases 53,892 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: U90716Y07593
genomic clones: R827P19 R877L16


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CXAR_HUMAN, P78310 (See protein sequence)
Recommended Name: Coxsackievirus and adenovirus receptor precursor  
Size: 365 amino acids; 40030 Da
Subunit: Monomer. May form homodimer. Interacts with LNX, BAIAP1, DLG4, PRKCABP, TJP1 and CTNNB1. Interacts with
MPDZ; recruits MPDZ to intercellular contact sites. Interacts with AMICA1 (homodimeric form). Secreted isoform 3,
isoform 4 and isoform 5 can interact with the extracellular domain of the receptor. Interacts with adenovirus
subgroups A, C, D, E and F fiber proteins as well as coxsackievirus B1, B2, B3, B4, B5 and B6 capsid proteins and
acts as a receptor for these viruses
Selected PDB 3D structures from and Proteopedia for CXADR (see all 12):
1EAJ (3D)        1F5W (3D)        1JEW (3D)        1KAC (3D)        1P69 (3D)        1P6A (3D)    
Secondary accessions: B2R8V8 B7WPI3 D3YHP0 O00694 Q8WWT6 Q8WWT7 Q8WWT8 Q9UKV4
Alternative splicing: 7 isoforms:  P78310-1   P78310-2   P78310-3   P78310-4   P78310-5   P78310-6   P78310-7   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for CXADR: NX_P78310

Explore proteomics data for CXADR at MOPED

Post-translational modifications: 

  • N-glycosylated (By similarity)1
  • Palmitoylated on Cys-259 and/or Cys-260; required for proper localization to the plasma membrane1
  • Glycosylation2 at Asn106, Asn201
  • Modification sites at PhosphoSitePlus

  • See CXADR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001193992.1  NP_001193993.1  NP_001193994.1  NP_001193995.1  NP_001329.1  

    ENSEMBL proteins: 
     ENSP00000284878   ENSP00000383030   ENSP00000348620   ENSP00000383029   ENSP00000383033  
     ENSP00000303395  
    Reactome Protein details: P78310

    CXADR Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CXADR
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CXADR
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    Novus Biologicals CXADR Proteins
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    Sino Biological Recombinant Protein for CXADR
    Sino Biological Cell Lysate for CXADR
    ProSpec Recombinant Protein for CXADR
    Cloud-Clone Corp. Proteins for CXADR

    CXADR Antibody Products:

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    LSBio Antibodies in human, mouse, rat for CXADR

    CXADR Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CXADR
    Cloud-Clone Corp. CLIAs for CXADR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P78310

    ProtoNet protein and cluster: P78310

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: CXAR_HUMAN, P78310
    Domain: The Ig-like C2-type 1 domain mediates homodimerization and interaction with AMICA1
    Domain: The PDZ-binding motif mediates interaction with MPDZ and BAIAP1
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    CXADR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CXAR_HUMAN, P78310
    Function: Component of the epithelial apical junction complex that may function as an homophilic cell adhesion
    molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes
    through adhesive interactions with AMICA1/JAML a transmembrane protein of the plasma membrane of leukocytes. The
    interaction between both receptors also mediates the activation of gamma-delta T cells, a subpopulation of T
    cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1
    induces downstream cell signaling events in gamma-delta T cells through PI3-kinase and MAP kinases. It results in
    proliferation and production of cytokines and growth factors by T cells that in turn stimulate epithelial tissues
    repair

         Genatlas biochemistry entry for CXADR:
    coxsackie B and adenovirus (group C) common receptor

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001618virus receptor activity IEA--
    GO:0005102receptor binding IPI14978041
    GO:0005178integrin binding IPI12869515
    GO:0005515protein binding IPI11734628
    GO:0008013beta-catenin binding IPI12297051
         
    CXADR for ontologies           About GeneDecksing


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Cxadr):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     muscle  respiratory system 

    CXADR for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CXADR: Cxadrtm2Know Cxadrtm1.1Mds Cxadrtm1Dvst Cxadrtm1Rwf

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CXADR
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CXADR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CXADR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CXADR

    miRNA
    Products:
        
    miRTarBase miRNAs that target CXADR:
    hsa-mir-296-3p (MIRT038505), hsa-mir-342-3p (MIRT043740), hsa-mir-375 (MIRT020061), hsa-mir-26b-5p (MIRT030352)

    Block miRNA regulation of human, mouse, rat CXADR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CXADR (see all 102):
    hsa-miR-411* hsa-miR-607 hsa-miR-199a-3p hsa-miR-200a hsa-miR-128 hsa-miR-374a hsa-miR-3653 hsa-miR-10b*
    SwitchGear 3'UTR luciferase reporter plasmidCXADR 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CXADR
    Predesigned siRNA for gene silencing in human, mouse, rat CXADR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CXADR

    Clone
    Products:
         
    OriGene clones in human, mouse for CXADR (see all 7)
    OriGene ORF clones in mouse, rat for CXADR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CXADR (NM_001338)
    Sino Biological Human cDNA Clone for CXADR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXADR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXADR

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXADR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CXAR_HUMAN, P78310: Isoform 1: Cell membrane; Single-pass type I membrane protein. Cell junction, tight
    junction. Cell junction, adherens junction. Basolateral cell membrane; Single-pass type I membrane protein.
    Note=In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions. In
    airway epithelial cells localized to basolateral membrane but not to apical surface
    CXAR_HUMAN, P78310: Isoform 2: Cell membrane; Single-pass type I membrane protein. Cell junction, tight
    junction. Cell junction, adherens junction. Basolateral cell membrane; Single-pass membrane protein. Note=In
    epithelial cells localizes to the apical junction complex composced of tight and adherens junctions. In airway
    epithelial cells localized to basolateral membrane but not to apical surface
    CXAR_HUMAN, P78310: Isoform 3: Secreted
    CXAR_HUMAN, P78310: Isoform 4: Secreted
    CXAR_HUMAN, P78310: Isoform 5: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    nucleus4
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle ISS--
    GO:0005576extracellular region IEA--
    GO:0005615extracellular space IDA14978041
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    CXADR for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CXADR About    
    See pathways by source

    SuperPathContained pathways About
    1Hemostasis
    Hemostasis0.43
    2Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    3Allograft rejection
    Viral myocarditis0.40
    4Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    5Cell surface interactions at the vascular wall
    Cell surface interactions at the vascular wall

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for CXADR
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Cell surface interactions at the vascular wall


    1 Kegg Pathway  (Kegg details for CXADR):
        Viral myocarditis


    CXADR for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CXADR
    Interactions:

        GeneGlobe Interaction Network for CXADR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for CXADR (P783102, 3 ENSP000002848784) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LNX1Q8TBB13, ENSP000002639254I2D: score=2 STRING: ENSP00000263925
    ACTBP607093, ENSP000003499604I2D: score=1 STRING: ENSP00000349960
    EWSR1Q018443, ENSP000003810314I2D: score=3 STRING: ENSP00000381031
    TRAPPC6AO758653I2D: score=1 
    TAPBPLENSP000002665564STRING: ENSP00000266556
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007005mitochondrion organization ISS--
    GO:0007157heterophilic cell-cell adhesion IDA12869515
    GO:0007507heart development ISS--
    GO:0007596blood coagulation TAS--
    GO:0008354germ cell migration ISS--

    CXADR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CXADR (CXAR)

    Selected Novoseek inferred chemical compound relationships for CXADR gene (see all 46)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    penton 86.4 9 15483666 (2), 12923563 (1), 15684699 (1), 11884569 (1) (see all 7)
    androstane 83.6 9 19196842 (1), 14567971 (1), 12695351 (1), 14978227 (1) (see all 8)
    citco 82.7 14 15802384 (1), 17585873 (1), 18492798 (1), 19925382 (1)
    cinacalcet 69.5 13 16816924 (2), 18561096 (2), 19765257 (2), 15631545 (1)
    depsipeptide 68 45 16356494 (4), 16951199 (3), 14614025 (2), 17308048 (2) (see all 9)
    ad 11 67.5 1 12915534 (1)
    hexon 58.2 2 15671566 (1), 16956941 (1)
    tcpobop 57.7 2 15802384 (1), 19925382 (1)
    calcium 51 230 15525493 (5), 7835282 (4), 20130845 (4), 9722568 (4) (see all 91)
    spermine 43.8 11 17041782 (2), 8694826 (1), 9677383 (1), 11108243 (1) (see all 8)



    CXADR for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CXADR gene (5 alternative transcripts): 
    NM_001207063.1  NM_001207064.1  NM_001207065.1  NM_001207066.1  NM_001338.4  

    Unigene Cluster for CXADR:

    Coxsackie virus and adenovirus receptor
    Hs.627078  [show with all ESTs]
    Unigene Representative Sequence: NM_001338
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000284878(uc002yki.3 uc002ykh.2 uc010gld.2 uc010gle.2 uc021whp.1)
    ENST00000400166 ENST00000356275 ENST00000400165 ENST00000400169(uc002ykj.2)
    ENST00000306618
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CXADR (see all 102):
    hsa-miR-411* hsa-miR-607 hsa-miR-199a-3p hsa-miR-200a hsa-miR-128 hsa-miR-374a hsa-miR-3653 hsa-miR-10b*
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    Primer
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    OriGene qPCR primer pairs and template standards for CXADR
    OriGene qSTAR qPCR primer pairs in human, mouse for CXADR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CXADR
      QuantiTect SYBR Green Assays in human, mouse, rat CXADR
      QuantiFast Probe-based Assays in human, mouse, rat CXADR

    Additional mRNA sequence: 

    AF124598.1 AK313526.1 AY072910.1 AY072911.1 AY072912.1 BC003684.1 BC010536.1 BT019876.1 
    GU474812.1 U90716.1 Y07593.1 

    12 DOTS entries:

    DT.95369288  DT.212280  DT.100778374  DT.100778367  DT.100757082  DT.315373  DT.100638716  DT.100814204 
    DT.121279063  DT.95369281  DT.215678  DT.75171993 

    Selected AceView cDNA sequences (see all 152):

    CR617256 AI686754 AI290221 AW778898 AA977172 AI718484 AI394410 AA176652 
    AI336853 AA128200 AA666170 AI369746 AI066454 AW779053 AW265156 BC010536 
    AL521066 BE503229 Y07593 BF062895 AA100291 BC003684 AI214281 AF124598 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CXADR    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c
    SP1:                                -                                                   
    SP2:                                -                       -     -                     
    SP3:                                -           -     -     -     -                     
    SP4:        -     -     -           -                                                   
    SP5:                                                                                    


    ECgene alternative splicing isoforms for CXADR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CXADR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTCTGTGTA
    CXADR Expression
    About this image


    CXADR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 7 entries
             hIPS1
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Bone Marrow
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
    CXADR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CXADR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.627078

    UniProtKB/Swiss-Prot: CXAR_HUMAN, P78310
    Tissue specificity: Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in
    liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In
    skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In
    cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial
    layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with
    dilated cardiomyopathy

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CXADR gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cxadr1 , 5 coxsackie virus and adenovirus receptor1, 5 83.56(n)1
    89.86(a)1
      16 (45.28 cM)5
    130521  NM_001025192.31  NP_001020363.11 
     783014965 
    chicken
    (Gallus gallus)
    Aves CXADR1 coxsackie virus and adenovirus receptor 67.31(n)
    61.98(a)
      418473  XM_004938354.1  XP_004938411.1 
    lizard
    (Anolis carolinensis)
    Reptilia CXADR6
    coxsackie virus and adenovirus receptor
    54(a)
    1 ↔ 1
    3(153714260-153758173)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.27042 Transcribed sequence with weak similarity to protein more 77.71(n)    AL956823.2 
    zebrafish
    (Danio rerio)
    Actinopterygii cxadr2 coxsackie virus and adenovirus receptor 73.3(n)   259305  BC045286.1 


    ENSEMBL Gene Tree for CXADR (if available)
    TreeFam Gene Tree for CXADR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CXADR gene
    CLMP2  ESAM2  VSIG82  GPA332  VSIG12  VSIG22  C1orf2042  IGSF112  
    3 SIMAP similar genes for CXADR using alignment to 1 protein entry:     CXAR_HUMAN:
    GPA33    IGSF11    CLMP

    CXADR for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for CXADR
    PGOHUM00000246625 PGOHUM00000246637 PGOHUM00000234879 PGOHUM00000258119


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CXADR (see all 2172)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs761065531,2
    C,F--9439045(+) TGTTGT/CCTTAC 5 -- us2k11Minor allele frequency- C:0.06WA 118
    rs1447906221,2
    --9439142(+) ACTACC/TACTGG 5 -- us2k10--------
    rs96471961,2
    C,H--9439188(+) TTCCCC/TTTAAA 5 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs790800501,2
    F--9439208(+) ATTGGA/CATCAC 5 -- us2k12Minor allele frequency- C:0.04CSA WA 120
    rs616946441,2
    C--9439247(+) TATAC-/ATATA 
            
    TAGAT
    5 -- us2k10--------
    rs2012315871,2
    --9439272(+) TAGAT-/AGATATT 5 -- us2k10--------
    rs130496331,2
    C,F--9439626(+) ATTGCA/GACTCA 5 -- us2k16Minor allele frequency- G:0.27WA NA CSA EA 364
    rs759085211,2
    C--9439692(+) CCCTTC/TTCTTT 5 -- us2k10--------
    rs1932398181,2
    --9439715(+) CATAAC/TAAGAA 5 -- us2k10--------
    rs1465428961,2
    --9439837(+) CATAAA/GCAGGA 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for CXADR (18884700 - 18965897 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CXADR:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2723192CNV Deletion23290073
    esv994798CNV Loss20482838
    dgv4684n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 602621    OMIM disorders: --

    Selected diseases for CXADR (see all 68):    
    About MalaCards
    familial hypocalciuric hypercalcemia    hyperparathyroidism    hypercalcemia    hypoparathyroidism
    parathyroid adenoma    myocarditis    malignant glioma    uremia
    primary hyperparathyroidism    bladder transitional cell carcinoma    gastrinoma    transitional cell carcinoma
    dilated cardiomyopathy    keratoconjunctivitis    glioblastoma multiforme    testicular cancer
    ovarian cancer    cervical cancer    meningioma    endometrial adenocarcinoma

    1 disease from the University of Copenhagen DISEASES database for CXADR:
    Myocarditis

    CXADR for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CXADR gene (see all 79)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenovirus infections 84.2 23 11972385 (2), 11207218 (2), 11522619 (1), 14614025 (1) (see all 19)
    nshpt 74.1 7 7717399 (2), 16509534 (2), 7593455 (1), 9769711 (1)
    coxsackie virus 66.9 8 16014330 (2), 12753648 (1), 12923563 (1), 14978758 (1) (see all 7)
    hyperparathyroidism secondary 57.4 3 15466262 (1), 16816924 (1), 19303957 (1)
    hypocalcemia, autosomal dominant 57 3 9769711 (2), 15591042 (1)
    epidemic keratoconjunctivitis 55 1 12429514 (1)
    hypercalcemia 54.7 16 12970167 (2), 9769711 (2), 8636323 (1), 11323743 (1) (see all 11)
    swine vesicular disease 52.8 2 10814575 (2)
    parathyroid adenoma 48 9 10024390 (2), 7759551 (2), 9854589 (1), 10352095 (1) (see all 7)
    urogenital cancer 45.5 6 14695181 (4)

    Genetic Association Database (GAD): CXADR
    Human Genome Epidemiology (HuGE) Navigator: CXADR (4 documents)

    Export disorders for CXADR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for CXADR gene, integrated from 10 sources (see all 459):
    (articles sorted by number of sources associating them with CXADR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. (PubMed id 9036860)1, 2, 3 Bergelson J.M.... Finberg R.W. (Science 1997)
    2. HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses. (PubMed id 9096397)1, 2, 3 Tomko R.P.... Philipson L. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    3. Human coxsackie-adenovirus receptor is colocalized with integrins alpha(v)beta(3) and alpha(v)beta(5) on the cardiomyocyte sarcolemma and upregulated in dilated cardiomyopathy: implications for cardiotropic viral infections. (PubMed id 11457744)1, 2, 9 Noutsias M.... Poller W. (Circulation 2001)
    4. Isoform-specific expression of the Coxsackie and adenovirus receptor (CAR) in neuromuscular junction and cardiac intercalated discs. (PubMed id 15533241)1, 2, 9 Shaw C.A.... Nalbantoglu J. (BMC Cell Biol. 2004)
    5. Alternatively spliced soluble coxsackie-adenovirus receptors inhibit coxsackievirus infection. (PubMed id 14978041)1, 2, 9 Doerner A.... Knowlton K.U. (J. Biol. Chem. 2004)
    6. A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth. (PubMed id 15304526)1, 2, 9 Ashbourne-Excoffon K.J.D....Zabner J. (J. Cell Sci. 2004)
    7. The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction. (PubMed id 11734628)1, 2, 9 Cohen C.J....Bergelson J.M. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    8. [Analysis of heterogeneity in exon 4 of Coxsackievirus and Adenovirus receptor gene in dilated cardiomyopathy]. (PubMed id 19100061)1, 4, 9 Zhang S....Yu B. (Zhonghua Xin Xue Guan Bing Za Zhi 2008)
    9. Fatty acid modification of the coxsackievirus and adenovirus receptor. (PubMed id 12021372)1, 2, 9 van't Hof W. and Crystal R.G. (J. Virol. 2002)
    10. Expression of Coxsackie-adenovirus-receptor and alpha v-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers. (PubMed id 10490761)1, 2, 9 Fechner H.... Poller W. (Gene Ther. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1525 HGNC: 2559 AceView: CXADR Ensembl:ENSG00000154639 euGenes: HUgn1525
    ECgene: CXADR Kegg: 1525 H-InvDB: CXADR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CXADR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CXADR gene:
    Search GeneIP for patents involving CXADR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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