Aliases for CXADR Gene
External Ids for CXADR Gene
Previous GeneCards Identifiers for CXADR Gene
The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. [provided by RefSeq, May 2011]
GeneCards Summary for CXADR Gene
CXADR (CXADR, Ig-Like Cell Adhesion Molecule) is a Protein Coding gene. Diseases associated with CXADR include Myocarditis and Familial Hypocalciuric Hypercalcemia. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Allograft rejection. GO annotations related to this gene include identical protein binding and integrin binding. An important paralog of this gene is ENSG00000277666.
UniProtKB/Swiss-Prot for CXADR Gene
Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.
(Microbial infection) Acts as a receptor for adenovirus type C (PubMed:9733828, PubMed:10666333, PubMed:12297051, PubMed:10567268). Acts as a receptor for Coxsackievirus B1 to B6 (PubMed:14978041, PubMed:10814575).