Aliases for CX3CR1 Gene
External Ids for CX3CR1 Gene
Previous HGNC Symbols for CX3CR1 Gene
Previous GeneCards Identifiers for CX3CR1 Gene
Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
GeneCards Summary for CX3CR1 Gene
CX3CR1 (C-X3-C Motif Chemokine Receptor 1) is a Protein Coding gene. Diseases associated with CX3CR1 include hiv-1 and macular degeneration, age-related, 12. Among its related pathways are Signaling by GPCR and A-beta Pathways: Uptake and Degradation. GO annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CCR9.
UniProtKB/Swiss-Prot for CX3CR1 Gene
Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1.