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Aliases for CX3CR1 Gene

Aliases for CX3CR1 Gene

  • Chemokine (C-X3-C Motif) Receptor 1 2 3
  • GPR13 3 4 6
  • V28 3 4 6
  • Beta Chemokine Receptor-Like 1 3 4
  • Chemokine (C-X3-C) Receptor 1 2 3
  • G-Protein Coupled Receptor 13 3 4
  • Fractalkine Receptor 3 4
  • C-X3-C CKR-1 3 4
  • CMK-BRL-1 3 4
  • CMK-BRL1 3 4
  • CMKBRL1 3 4
  • Chemokine (C-C) Receptor-Like 1 3
  • G Protein-Coupled Receptor 13 3
  • CX3C Chemokine Receptor 1 3
  • CMKDR1 3
  • GPRV28 3
  • CCRL1 3

External Ids for CX3CR1 Gene

Previous Symbols for CX3CR1 Gene

  • GPR13
  • CMKBRL1

Summaries for CX3CR1 Gene

Entrez Gene Summary for CX3CR1 Gene

  • Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

GeneCards Summary for CX3CR1 Gene

CX3CR1 (Chemokine (C-X3-C Motif) Receptor 1) is a Protein Coding gene. Diseases associated with CX3CR1 include htlv-1 associated myelopathy/tropical spastic paraparesis and macular degeneration, age-related, 12. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include chemokine receptor activity and C-X3-C chemokine receptor activity. An important paralog of this gene is CCR7.

UniProtKB/Swiss-Prot for CX3CR1 Gene

  • Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1

Gene Wiki entry for CX3CR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CX3CR1 Gene

Genomics for CX3CR1 Gene

Genomic Location for CX3CR1 Gene

Start:
39,263,494 bp from pter
End:
39,281,735 bp from pter
Size:
18,242 bases
Orientation:
Minus strand

Genomic View for CX3CR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CX3CR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CX3CR1 Gene

Regulatory Elements for CX3CR1 Gene

Proteins for CX3CR1 Gene

  • Protein details for CX3CR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49238-CX3C1_HUMAN
    Recommended name:
    CX3C chemokine receptor 1
    Protein Accession:
    P49238
    Secondary Accessions:
    • A0N0N6
    • B2R5Z4
    • J3KP17

    Protein attributes for CX3CR1 Gene

    Size:
    355 amino acids
    Molecular mass:
    40396 Da
    Quaternary structure:
    • Interacts with human respiratory syncytial virus (HRSV) protein G; this interaction modulates host immune response. Interacts with HIV-1 envelope polyprotein gp160.

    Alternative splice isoforms for CX3CR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CX3CR1 Gene

Proteomics data for CX3CR1 Gene at MOPED

Post-translational modifications for CX3CR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CX3CR1 Gene

No data available for DME Specific Peptides for CX3CR1 Gene

Domains for CX3CR1 Gene

Gene Families for CX3CR1 Gene

HGNC:
  • CX3CR :GPCR / Class A : Chemokine receptors : C-X-3-C motif
IUPHAR :

UniProtKB/Swiss-Prot:

CX3C1_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • P49238
genes like me logo Genes that share domains with CX3CR1: view

Function for CX3CR1 Gene

Molecular function for CX3CR1 Gene

GENATLAS Biochemistry: fractalkine receptor CX3CR1,expressed in T lymphocytes,polynuclear,G protein coupled receptor superfamily,mediating leukocyte migration and adhesion
UniProtKB/Swiss-Prot Function: Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1

Gene Ontology (GO) - Molecular Function for CX3CR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 cytokine receptor activity --
GO:0004930 G-protein coupled receptor activity --
GO:0004950 chemokine receptor activity TAS 10754298
GO:0005515 protein binding IPI 9931005
GO:0016495 C-X3-C chemokine receptor activity IEA --
genes like me logo Genes that share ontologies with CX3CR1: view
genes like me logo Genes that share phenotypes with CX3CR1: view

Animal Models for CX3CR1 Gene

MGI Knock Outs for CX3CR1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CX3CR1 Gene

Localization for CX3CR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CX3CR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CX3CR1 Gene COMPARTMENTS Subcellular localization image for CX3CR1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CX3CR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9390561
GO:0016021 integral component of membrane --
GO:0032809 neuronal cell body membrane IEA --
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with CX3CR1: view

Pathways for CX3CR1 Gene

genes like me logo Genes that share pathways with CX3CR1: view

Gene Ontology (GO) - Biological Process for CX3CR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002282 microglial cell activation involved in immune response IEA --
GO:0006935 chemotaxis TAS 10754298
GO:0006968 cellular defense response TAS 10754298
GO:0007155 cell adhesion IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with CX3CR1: view

Compounds for CX3CR1 Gene

(2) IUPHAR Ligand for CX3CR1 Gene

Ligand Type Action Affinity Pubmed IDs
CX3CL1 Agonist Full agonist 8.9
[125I]CX3CL1 (human) Agonist Full agonist

(9) Novoseek inferred chemical compound relationships for CX3CR1 Gene

Compound -log(P) Hits PubMed IDs
rantes 64.1 12
ccl3 62.8 3
grgdsp 45.7 1
ccl4 22.5 2
linoleic acid 15 1
genes like me logo Genes that share compounds with CX3CR1: view

Transcripts for CX3CR1 Gene

Unigene Clusters for CX3CR1 Gene

Chemokine (C-X3-C motif) receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CX3CR1 Gene

No ASD Table

Relevant External Links for CX3CR1 Gene

GeneLoc Exon Structure for
CX3CR1
ECgene alternative splicing isoforms for
CX3CR1

Expression for CX3CR1 Gene

mRNA expression in normal human tissues for CX3CR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CX3CR1 Gene

This gene is overexpressed in Whole Blood (13.5), Brain - Spinal cord (cervical c-1) (6.6), and Brain - Substantia nigra (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CX3CR1 Gene

SOURCE GeneReport for Unigene cluster for CX3CR1 Gene Hs.78913

mRNA Expression by UniProt/SwissProt for CX3CR1 Gene

P49238-CX3C1_HUMAN
Tissue specificity: Expressed in lymphoid and neural tissues
genes like me logo Genes that share expressions with CX3CR1: view

Orthologs for CX3CR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CX3CR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CX3CR1 36
  • 99.34 (n)
  • 98.31 (a)
CX3CR1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CX3CR1 36
  • 84.62 (n)
  • 80.91 (a)
CX3CR1 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CX3CR1 36
  • 86.99 (n)
  • 84.9 (a)
CX3CR1 37
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cx3cr1 36
  • 80.72 (n)
  • 83.48 (a)
Cx3cr1 16
Cx3cr1 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CX3CR1 37
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CX3CR1 37
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cx3cr1 36
  • 79.87 (n)
  • 82.91 (a)
chicken
(Gallus gallus)
Aves CX3CR1 36
  • 61.35 (n)
  • 53.85 (a)
CX3CR1 37
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CX3CR1 37
  • 47 (a)
OneToOne
Species with no ortholog for CX3CR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CX3CR1 Gene

ENSEMBL:
Gene Tree for CX3CR1 (if available)
TreeFam:
Gene Tree for CX3CR1 (if available)

Paralogs for CX3CR1 Gene

genes like me logo Genes that share paralogs with CX3CR1: view

Variants for CX3CR1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CX3CR1 Gene

P49238-CX3C1_HUMAN
Variations in CX3CR1 are associated with rapid progression to AIDS [MIM:609423]. Increased susceptibility to HIV infection and rapid progression to AIDS are associated with the Ile-249/Met-280 haplotype

Sequence variations from dbSNP and Humsavar for CX3CR1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs871144 -- 39,280,975(-) GTCAC(A/G)GACCA intron-variant, upstream-variant-2KB
rs871610 -- 39,280,376(+) GCCCA(C/T)GAGAG intron-variant, utr-variant-5-prime, upstream-variant-2KB
rs938203 -- 39,281,174(+) TGCTC(A/G)TGGTG utr-variant-5-prime, upstream-variant-2KB, intron-variant
rs1050592 -- 39,265,293(-) GAGAA(C/T)TGTGC utr-variant-3-prime
rs1513256 -- 39,275,945(+) CTGCC(A/G)TTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CX3CR1 Gene

Variant ID Type Subtype PubMed ID
nsv3772 CNV Insertion 18451855

Relevant External Links for CX3CR1 Gene

HapMap Linkage Disequilibrium report
CX3CR1
Human Gene Mutation Database (HGMD)
CX3CR1

Disorders for CX3CR1 Gene

(3) OMIM Diseases for CX3CR1 Gene (601470)

UniProtKB/Swiss-Prot

CX3C1_HUMAN
  • Macular degeneration, age-related, 12 (ARMD12) [MIM:613784]: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for CX3CR1 Gene

(30) Novoseek inferred disease relationships for CX3CR1 Gene

Disease -log(P) Hits PubMed IDs
inflammation 50.2 15
atherosclerosis 49 11
rheumatoid arthritis 38 7
hiv infections 32.9 10
immunodeficiency 30.5 3

Relevant External Links for CX3CR1

Genetic Association Database (GAD)
CX3CR1
Human Genome Epidemiology (HuGE) Navigator
CX3CR1
genes like me logo Genes that share disorders with CX3CR1: view

Publications for CX3CR1 Gene

  1. Cloning, chromosomal localization, and RNA expression of a human beta chemokine receptor-like gene. (PMID: 7646814) Combadiere C. … Murphy P.M. (DNA Cell Biol. 1995) 2 3 4 23
  2. Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1. (PMID: 9726990) Combadiere C. … Murphy P.M. (J. Biol. Chem. 1998) 2 3 4 23
  3. Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease. (PMID: 11264153) Moatti D. … Combadiere C. (Blood 2001) 3 4 23 49
  4. Influence of polymorphisms within the CX3CR1 and MDR-1 genes on initial antiretroviral therapy response. (PMID: 12545080) Brumme Z.L. … Harrigan P.R. (AIDS 2003) 3 23 49
  5. Genomic organization and evolution of the CX3CR1/CCR8 chemokine receptor locus. (PMID: 12551893) DeVries M.E. … Kelvin D.J. (J. Biol. Chem. 2003) 3 4 23

Products for CX3CR1 Gene

Sources for CX3CR1 Gene

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