Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CX3CR1 Gene

Aliases for CX3CR1 Gene

  • C-X3-C Motif Chemokine Receptor 1 2 3
  • Chemokine (C-X3-C Motif) Receptor 1 2 3 5
  • Beta Chemokine Receptor-Like 1 3 4
  • Chemokine (C-X3-C) Receptor 1 2 3
  • G-Protein Coupled Receptor 13 3 4
  • Fractalkine Receptor 3 4
  • C-X3-C CKR-1 3 4
  • CMK-BRL-1 3 4
  • CMK-BRL1 3 4
  • CMKBRL1 3 4
  • GPR13 3 4
  • V28 3 4
  • Chemokine (C-C) Receptor-Like 1 3
  • G Protein-Coupled Receptor 13 3
  • CMKDR1 3
  • GPRV28 3
  • CCRL1 3

External Ids for CX3CR1 Gene

Previous HGNC Symbols for CX3CR1 Gene

  • GPR13
  • CMKBRL1

Previous GeneCards Identifiers for CX3CR1 Gene

  • GC03M038644
  • GC03M038538
  • GC03M039118
  • GC03M039265

Summaries for CX3CR1 Gene

Entrez Gene Summary for CX3CR1 Gene

  • Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

GeneCards Summary for CX3CR1 Gene

CX3CR1 (C-X3-C Motif Chemokine Receptor 1) is a Protein Coding gene. Diseases associated with CX3CR1 include Hiv-1 and Macular Degeneration, Age-Related, 12. Among its related pathways are Peptide ligand-binding receptors and ERK Signaling. GO annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CCR9.

UniProtKB/Swiss-Prot for CX3CR1 Gene

  • Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1.

Gene Wiki entry for CX3CR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CX3CR1 Gene

Genomics for CX3CR1 Gene

Regulatory Elements for CX3CR1 Gene

Enhancers for CX3CR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CX3CR1 on UCSC Golden Path with GeneCards custom track

Promoters for CX3CR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CX3CR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CX3CR1 Gene

Chromosome:
3
Start:
39,263,494 bp from pter
End:
39,281,735 bp from pter
Size:
18,242 bases
Orientation:
Minus strand

Genomic View for CX3CR1 Gene

Genes around CX3CR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CX3CR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CX3CR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CX3CR1 Gene

Proteins for CX3CR1 Gene

  • Protein details for CX3CR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49238-CX3C1_HUMAN
    Recommended name:
    CX3C chemokine receptor 1
    Protein Accession:
    P49238
    Secondary Accessions:
    • A0N0N6
    • B2R5Z4
    • J3KP17

    Protein attributes for CX3CR1 Gene

    Size:
    355 amino acids
    Molecular mass:
    40396 Da
    Quaternary structure:
    • Interacts with human respiratory syncytial virus (HRSV) protein G; this interaction modulates host immune response. Interacts with HIV-1 envelope polyprotein gp160.

    Alternative splice isoforms for CX3CR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CX3CR1 Gene

Proteomics data for CX3CR1 Gene at MOPED

Post-translational modifications for CX3CR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for CX3CR1 Gene

Domains & Families for CX3CR1 Gene

Gene Families for CX3CR1 Gene

Suggested Antigen Peptide Sequences for CX3CR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49238

UniProtKB/Swiss-Prot:

CX3C1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CX3CR1: view

Function for CX3CR1 Gene

Molecular function for CX3CR1 Gene

GENATLAS Biochemistry:
fractalkine receptor CX3CR1,expressed in T lymphocytes,polynuclear,G protein coupled receptor superfamily,mediating leukocyte migration and adhesion
UniProtKB/Swiss-Prot Function:
Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1.

Gene Ontology (GO) - Molecular Function for CX3CR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with CX3CR1: view
genes like me logo Genes that share phenotypes with CX3CR1: view

Animal Models for CX3CR1 Gene

MGI Knock Outs for CX3CR1:

Animal Model Products

miRNA for CX3CR1 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CX3CR1 Gene

Localization for CX3CR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CX3CR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CX3CR1 Gene COMPARTMENTS Subcellular localization image for CX3CR1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
cytosol 1
extracellular 1
nucleus 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CX3CR1 Gene

Pathways & Interactions for CX3CR1 Gene

genes like me logo Genes that share pathways with CX3CR1: view

SIGNOR curated interactions for CX3CR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CX3CR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007613 memory IEA --
GO:0009611 response to wounding TAS 10754298
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with CX3CR1: view

Drugs & Compounds for CX3CR1 Gene

(6) Drugs for CX3CR1 Gene - From: DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>125</sup>I]CX<sub>3</sub>CL1 (human) Pharma Full agonist, Agonist 0
CX<sub>3</sub>CL1 Pharma Full agonist, Agonist 0

(5) Additional Compounds for CX3CR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CX3CR1: view

Transcripts for CX3CR1 Gene

Unigene Clusters for CX3CR1 Gene

Chemokine (C-X3-C motif) receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CX3CR1 Gene

No ASD Table

Relevant External Links for CX3CR1 Gene

GeneLoc Exon Structure for
CX3CR1
ECgene alternative splicing isoforms for
CX3CR1

Expression for CX3CR1 Gene

mRNA expression in normal human tissues for CX3CR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CX3CR1 Gene

This gene is overexpressed in Whole Blood (x13.5), Brain - Spinal cord (cervical c-1) (x6.6), and Brain - Substantia nigra (x5.5).

Protein differential expression in normal tissues from HIPED for CX3CR1 Gene

This gene is overexpressed in Adrenal (26.8), Lung (15.5), and Liver (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CX3CR1 Gene



SOURCE GeneReport for Unigene cluster for CX3CR1 Gene Hs.78913

mRNA Expression by UniProt/SwissProt for CX3CR1 Gene

P49238-CX3C1_HUMAN
Tissue specificity: Expressed in lymphoid and neural tissues.
genes like me logo Genes that share expression patterns with CX3CR1: view

Primer Products

No data available for Protein tissue co-expression partners for CX3CR1 Gene

Orthologs for CX3CR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CX3CR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CX3CR1 35
  • 84.62 (n)
  • 80.91 (a)
CX3CR1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CX3CR1 35
  • 86.99 (n)
  • 84.9 (a)
CX3CR1 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cx3cr1 35
  • 80.72 (n)
  • 83.48 (a)
Cx3cr1 16
Cx3cr1 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CX3CR1 35
  • 99.34 (n)
  • 98.31 (a)
CX3CR1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cx3cr1 35
  • 79.87 (n)
  • 82.91 (a)
oppossum
(Monodelphis domestica)
Mammalia CX3CR1 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CX3CR1 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves CX3CR1 35
  • 61.35 (n)
  • 53.85 (a)
CX3CR1 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CX3CR1 36
  • 47 (a)
OneToOne
Species with no ortholog for CX3CR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CX3CR1 Gene

ENSEMBL:
Gene Tree for CX3CR1 (if available)
TreeFam:
Gene Tree for CX3CR1 (if available)

Paralogs for CX3CR1 Gene

genes like me logo Genes that share paralogs with CX3CR1: view

Variants for CX3CR1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CX3CR1 Gene

CX3C1_HUMAN-P49238
Variations in CX3CR1 are associated with rapid progression to AIDS [MIM:609423]. Increased susceptibility to HIV infection and rapid progression to AIDS are associated with the Ile-249/Met-280 haplotype.

Sequence variations from dbSNP and Humsavar for CX3CR1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_010041 -
rs143001773 - 39,266,146(+) GATGA(C/T)GGTGA reference, missense
rs3732379 - 39,265,765(+) CATAA(C/T)GTTGT reference, missense
rs3732378 - 39,265,671(+) CAACC(A/G)TCTCA reference, missense
rs3732380 - 39,266,071(+) GGTGA(C/T)GCCAT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CX3CR1 Gene

Variant ID Type Subtype PubMed ID
nsv3772 CNV Insertion 18451855

Variation tolerance for CX3CR1 Gene

Residual Variation Intolerance Score: 92.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.09; 75.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CX3CR1 Gene

Human Gene Mutation Database (HGMD)
CX3CR1

Disorders for CX3CR1 Gene

MalaCards: The human disease database

(11) MalaCards diseases for CX3CR1 Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
macular degeneration, age-related, 12
  • armd12
coronary artery disease
  • chronic myocardial ischemia
retinal vasculitis
  • retinal vasculitis nos
cerebrovascular disease
  • stroke
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

CX3C1_HUMAN
  • Macular degeneration, age-related, 12 (ARMD12) [MIM:613784]: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. {ECO:0000269 PubMed:15208270}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for CX3CR1

Genetic Association Database (GAD)
CX3CR1
Human Genome Epidemiology (HuGE) Navigator
CX3CR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CX3CR1
genes like me logo Genes that share disorders with CX3CR1: view

No data available for Genatlas for CX3CR1 Gene

Publications for CX3CR1 Gene

  1. Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1. (PMID: 9726990) Combadiere C. … Murphy P.M. (J. Biol. Chem. 1998) 2 3 4 23 67
  2. Cloning, chromosomal localization, and RNA expression of a human beta chemokine receptor-like gene. (PMID: 7646814) Combadiere C. … Murphy P.M. (DNA Cell Biol. 1995) 2 3 23
  3. Angiotensin II up-regulates CX3CR1 expression in THP-1 monocytes: impact on vascular inflammation and atherogenesis. (PMID: 19915801) Apostolakis S. … Spandidos D.A. (J. Thromb. Thrombolysis 2010) 3 23
  4. Upregulation of fractalkine and its receptor, CX3CR1, is associated with coronary plaque rupture in patients with unstable angina pectoris. (PMID: 20019415) Ikejima H. … Akasaka T. (Circ. J. 2010) 3 23
  5. Relationship between CX3CR1 genetic polymorphism and carotid atherosclerosis. (PMID: 20047517) Zhao R. … Sun Y. (Artif Cells Blood Substit Immobil Biotechnol 2010) 3 23

Products for CX3CR1 Gene

Sources for CX3CR1 Gene

Content