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CX3CL1 Gene

protein-coding   GIFtS: 62
GCID: GC16P057406

Chemokine (C-X3-C Motif) Ligand 1

(Previous names: small inducible cytokine subfamily D (Cys-X3-Cys), member...)
(Previous symbol: SCYD1)
  See CX3CL1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-X3-C Motif) Ligand 11 2     C3Xkine2
SCYD11 2 3 5     CXC32
NTT2 3 5     CXC3C2
Small Inducible Cytokine Subfamily D (Cys-X3-Cys), Member 1 (Fractalkine,
Neurotactin)1 2
     fractalkine2
Small-Inducible Cytokine D12 3     neurotactin2
C-X3-C Motif Chemokine 12 3     Small Inducible Cytokine Subfamily D (Cys-X3-Cys), Member-12
CX3C Membrane-Anchored Chemokine2 3     FKN3
NTN2 5     Neurotactin3
ABCD-32     

External Ids:    HGNC: 106471   Entrez Gene: 63762   Ensembl: ENSG000000062107   OMIM: 6018805   UniProtKB: P784233   

Export aliases for CX3CL1 gene to outside databases

Previous GC identifers: GC16P047801 GC16P057466 GC16P057140 GC16P057181 GC16P057162 GC16P055963 GC16P043274


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CX3CL1 Gene:
CX3CL1 (chemokine (C-X3-C motif) ligand 1) is a protein-coding gene. Diseases associated with CX3CL1 include chorioretinitis, and pityriasis rosea. GO annotations related to this gene include chemokine activity and receptor binding.

UniProtKB/Swiss-Prot: X3CL1_HUMAN, P78423
Function: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound
form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion
and migration processes at the endothelium. Binds to CX3CR1

Gene Wiki entry for CX3CL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CX3CL1 gene promoter:
         AP-1   ATF-2   c-Jun   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCX3CL1 promoter sequence
   Search Chromatin IP Primers for CX3CL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CX3CL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q13

CX3CL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CX3CL1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P057406:  view genomic region     (about GC identifiers)

Start:
57,406,370 bp from pter      End:
57,418,960 bp from pter
Size:
12,591 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: X3CL1_HUMAN, P78423 (See protein sequence)
Recommended Name: Fractalkine precursor  
Size: 397 amino acids; 42203 Da
Subunit: Monomer. Interacts with pox virus crmD; this inhibits cell migration mediated by CX3CL1
3 PDB 3D structures from and Proteopedia for CX3CL1:
1B2T (3D)        1F2L (3D)        3ONA (3D)    
Secondary accessions: O00672

Explore the universe of human proteins at neXtProt for CX3CL1: NX_P78423

Explore proteomics data for CX3CL1 at MOPED

Post-translational modifications: 

  • A soluble short 95 kDa form may be released by proteolytic cleavage from the long membrane-anchored form (By
    similarity)1
  • O-glycosylated with core 1 or possibly core 8 glycans1
  • Glycosylation2 at Asn33, Thr183, Ser253, Thr318, Thr329
  • Modification sites at PhosphoSitePlus

  • See CX3CL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002987.1  
    ENSEMBL proteins: 
     ENSP00000006053   ENSP00000456830   ENSP00000457996   ENSP00000464114  
    Reactome Protein details: P78423

    CX3CL1 Human Recombinant Protein Products:

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    OriGene Purified Protein for CX3CL1
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CX3CL1
    GenScript Purified and Recombinant Proteins for CX3CL1
    Novus Biologicals CX3CL1 Proteins
    Sino Biological Recombinant Protein for CX3CL1
    Sino Biological Cell Lysate for CX3CL1
    ProSpec Recombinant Protein for CX3CL1
    Cloud-Clone Corp. Proteins for CX3CL1

     
    Search eBioscience for Proteins for CX3CL1 

    CX3CL1 Antibody Products:

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    R&D Systems Antibodies for CX3CL1 (CX3CL1/Fractalkine)
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    CX3CL1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Search eBioscience for ELISAs for CX3CL1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    2 InterPro protein domains:
     IPR008097 Chemokine_CX3CL1
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry P78423

    ProtoNet protein and cluster: P78423

    1 Blocks protein domain: IPB008097 Fractalkine/neurotactin precursor signature

    UniProtKB/Swiss-Prot: X3CL1_HUMAN, P78423
    Similarity: Belongs to the intercrine delta family


    Find genes that share domains with CX3CL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: X3CL1_HUMAN, P78423
    Function: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound
    form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion
    and migration processes at the endothelium. Binds to CX3CR1
    Induction: By TNF and IL1/interleukin-1 in pulmonary endothelial cells and umbilical vein endothelial cells

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS12714508
    GO:0005515protein binding IPI9931005
    GO:0008009chemokine activity TAS12714508
         
    Find genes that share ontologies with CX3CL1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CX3CL1:
     Decreased viability of wild-ty  Increased circadian period len 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cx3cl1):
     behavior/neurological  cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism 
     immune system  nervous system 

    Find genes that share phenotypes with CX3CL1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CX3CL1: Cx3cl1tm1Sgs Cx3cl1tm1Lira

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CX3CL1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CX3CL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CX3CL1

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    Selected qRT-PCR Assays for microRNAs that regulate CX3CL1 (see all 35):
    hsa-miR-21* hsa-miR-185* hsa-miR-106a hsa-miR-509-5p hsa-miR-15a hsa-miR-29a hsa-miR-29c hsa-let-7a-2*
    SwitchGear 3'UTR luciferase reporter plasmidCX3CL1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CX3CL1
    Predesigned siRNA for gene silencing in human, mouse, rat CX3CL1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: CX3CL1 (NM_002996)
    Sino Biological Human cDNA Clone for CX3CL1
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CX3CL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    X3CL1_HUMAN, P78423: Cell membrane; Single-pass type I membrane protein
    X3CL1_HUMAN, P78423: Processed fractalkine: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    nucleus2
    cytoskeleton1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IDA12714508
    GO:0005615extracellular space IEA--
    GO:0005886plasma membrane TAS--
    GO:0009986cell surface IDA12714508
    GO:0016020membrane ----

    Find genes that share ontologies with CX3CL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CX3CL1 About   (see all 12)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    IL-6 Pathway0.61
    MIF Mediated Glucocorticoid Regulation0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43
    2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine receptors bind chemokines0.81
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    3Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    4Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61


    Find genes that share SuperPaths with CX3CL1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for CX3CL1
        A-beta Uptake & Degradation
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CX3CL1 (see all 17)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    MIF Mediated Glucocorticoid Regulation

    1 BioSystems Pathway for CX3CL1
        Direct p53 effectors


    1 Reactome Pathway for CX3CL1
        Chemokine receptors bind chemokines


    3 Kegg Pathways  (Kegg details for CX3CL1):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    TNF signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CX3CL1 (see all 9): 
              HIV Host Response in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Notch Signaling Targets in human mouse rat
              Th17 Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CX3CL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for CX3CL1 (P784233 ENSP000000060534) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CX3CR1P492383, ENSP000003821664I2D: score=3 STRING: ENSP00000382166
    TP53ENSP000002693054STRING: ENSP00000269305
    CCR1ENSP000002961404STRING: ENSP00000296140
    CCR10ENSP000003325044STRING: ENSP00000332504
    CCR2ENSP000002923014STRING: ENSP00000292301
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis IDA--
    GO:0006952defense response TAS12714508
    GO:0006955immune response TAS12714508
    GO:0007155cell adhesion IEA--
    GO:0019221cytokine-mediated signaling pathway TAS11777952

    Find genes that share ontologies with CX3CL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CX3CL1 (X3CL1)

    7 Novoseek inferred chemical compound relationships for CX3CL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tarc 60.3 3 11397698 (1), 9691168 (1), 10372118 (1)
    ccl4 26.1 4 16452465 (3), 18565769 (1)
    forskolin 0 9 11163337 (3), 1360635 (3)
    calcium 0 1 16166268 (1)
    glutamate 0 1 10640747 (1)
    serine 0 4 2100266 (2), 2120047 (1), 18436581 (1)
    cysteine 0 3 15361546 (1), 9177350 (1)



    Find genes that share compounds with CX3CL1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CX3CL1 gene: 
    NM_002996.3  

    Unigene Cluster for CX3CL1:

    Chemokine (C-X3-C motif) ligand 1
    Hs.531668  [show with all ESTs]
    Unigene Representative Sequence: AB209037
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000006053(uc002eli.3) ENST00000563383 ENST00000564948 ENST00000565912

    miRNA
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    hsa-miR-21* hsa-miR-185* hsa-miR-106a hsa-miR-509-5p hsa-miR-15a hsa-miR-29a hsa-miR-29c hsa-let-7a-2*
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      QuantiTect SYBR Green Assays in human, mouse, rat CX3CL1
      QuantiFast Probe-based Assays in human, mouse, rat CX3CL1

    Additional mRNA sequence: 

    AB209037.1 AK222692.1 AK223351.1 AK313806.1 BC001163.1 BC016164.1 CR457426.1 GU047346.1 
    U84487.1 U91835.1 

    7 DOTS entries:

    DT.445170  DT.100754639  DT.100027835  DT.100663663  DT.92430608  DT.100027838  DT.100677031 

    Selected AceView cDNA sequences (see all 192):

    BI765277 BI766891 BI822306 AI560343 AA595197 BI754355 CA395409 AL536123 
    BQ878197 BC001163 BQ893231 BM709856 AA349609 AA349491 BI752894 BI914377 
    CR595915 BQ045219 BE263269 T31247 CB960463 AI369215 BI769456 CA396869 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CX3CL1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:              -               


    ECgene alternative splicing isoforms for CX3CL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CX3CL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACAAGGATG
    CX3CL1 Expression
    About this image


    CX3CL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebellum
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
    CX3CL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CX3CL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.531668

    UniProtKB/Swiss-Prot: X3CL1_HUMAN, P78423
    Tissue specificity: Small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and
    pancreas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CX3CL1 (see all 9): 
              HIV Host Response in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Notch Signaling Targets in human mouse rat
              Th17 Response in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CX3CL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for CX3CL1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cx3cl11 , 5 chemokine (C-X3-C motif) ligand 11, 5 73.33(n)1
    66.92(a)1
      8 (46.79 cM)5
    203121  NM_009142.31  NP_033168.21 
     947720095 


    ENSEMBL Gene Tree for CX3CL1 (if available)
    TreeFam Gene Tree for CX3CL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CX3CL1 gene
    17 SIMAP similar genes for CX3CL1 using alignment to 6 protein entries:     X3CL1_HUMAN (see all proteins):
    CCL11    CCL8    CCL2    CCL7    MCP-3    LOC728835
    CCL18    CCL3    CCL3L1    CCL3L3    CCL4L2    CCL14
    CCL4L1    CCL4    CCL13    CCL17    CCL26

    Find genes that share paralogs with CX3CL1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for CX3CL1 (see all 404)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1127113411,2
    C--57413239(+) AACTC-/AAAAAA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1148475501,2
    C,F--58417566(+) TATGGA/GCATAA 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1477329091,2
    --58417596(+) TGGTCC/TTCGCA 1 -- us2k10--------
    rs1425537151,2
    C--58417601(+) CTCGCA/GGTGAG 1 -- us2k10--------
    rs1448602201,2
    C--58417671(+) GGGACA/GAATCC 1 -- us2k10--------
    rs1458018911,2
    --58417761(+) TCACCC/GAGGCT 1 -- us2k10--------
    rs1488627481,2
    --58417779(+) AGTGGC/TGTGAT 1 -- us2k10--------
    rs71967071,2
    C--58417800(+) tgcaaC/Tcctct 1 -- us2k10--------
    rs1911364121,2
    --58417827(+) CGATTC/TTCCTG 1 -- us2k10--------
    rs1434945261,2
    C--58417896(+) ATTTTC/TAGTAG 1 -- us2k10--------
    rs2238131,2
    C,F,A--58417916(+) ttcacT/Cgtgtt 1 -- us2k17Minor allele frequency- C:0.33NA WA CSA 12
    rs2238141,2
    C,F,A--58417996(+) acaggT/Cgtgag 1 -- us2k17Minor allele frequency- C:0.33NA WA CSA 12
    rs1825957621,2
    C--58418221(+) TGTTCC/TGCTAC 1 -- us2k10--------
    rs38345561,2
    C--58418297(-) CCCCC-/CGCCCC 1 -- us2k1 tfbs30--------
    rs1168022801,2
    --58418332(+) CCTGGC/TCTTGG 1 -- us2k10--------
    rs746119251,2
    C--58418364(+) GCCCAA/TCTGGC 1 -- us2k10--------
    rs790800601,2
    C--58418365(+) CCCAAC/TTGGCT 1 -- us2k10--------
    rs1129957871,2
    C--58418465(+) GCTGCT/AGACTC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1449076851,2
    C--58418596(+) AGGGCC/TGGTGC 1 -- us2k10--------
    rs1387381691,2
    C--58418671(+) CCACGA/GGAGGC 1 -- us2k10--------
    rs1881738691,2
    --58418793(+) TGGGAA/GTGGGT 1 -- us2k10--------
    rs727868701,2
    --58418851(+) GCTCTC/TTCCTG 1 -- us2k10--------
    rs1418330901,2
    C--58418905(+) GGAGTC/TCTCCA 1 -- us2k10--------
    rs41511161,2
    C,F,H--58418942(+) GGCTCT/CGGGCC 1 -- us2k16Minor allele frequency- C:0.27NS EA NA 576
    rs1507782801,2
    --58419069(+) AAGGTC/GCCCCA 1 -- us2k10--------
    rs2238151,2
    C,F,A,H--58419165(+) ACCCAG/CGATGG 1 -- us2k120Minor allele frequency- C:0.11NS EA NA WA CSA 2295
    rs1929705991,2
    --58419313(+) GGAGGC/GCTTTG 1 -- us2k10--------
    rs129177791,2
    C--58419426(+) ACATCA/CTGAGG 1 -- us2k1 tfbs30--------
    rs1380316881,2
    C--58419486(+) GCCTGC/TGGGGG 1 -- us2k10--------
    rs23017721,2
    C,F,H--58419545(+) GCGGCG/AGCAAG 1 -- us2k15Minor allele frequency- A:0.01EA NS 1904
    rs2004444951,2
    --58419585(+) CTAGCC/TGCCTG 1 -- ut510--------
    rs1995066061,2
    --58419586(+) TAGCCA/GCCTGC 1 -- ut510--------
    rs1905690131,2
    C--58419601(+) CCCCCA/GCCGGG 1 -- ut510--------
    rs2013770961,2
    --58419611(+) GACTCC/TTGCCC 1 -- ut510--------
    rs1408545571,2
    C,F--58419634(+) GGCTCC/TGATAT 2 P L mis11Minor allele frequency- T:0.00NA 4550
    rs1415051731,2
    C,F--58419647(+) CTGTCG/ATGGCT 2 /S syn11Minor allele frequency- A:0.00NA 4550
    rs2006048561,2
    C--58419653(+) TGGCTG/TCTCCG 2 L syn11Minor allele frequency- T:0.00EU 1291
    rs1461882251,2
    C,F--58419658(+) GCTCCG/ACTTGG 2 /H /R mis11Minor allele frequency- A:0.00NA 4546
    rs2016083701,2
    C,F--58419665(+) TTGGCC/TACCTT 2 A syn11Minor allele frequency- T:0.00EU 1285
    rs765052971,2
    C--58419717(+) CTTGGC/GCACAA 1 -- int10--------
    rs735592161,2
    C,F--58419808(+) AAGGCC/TGGTGG 1 -- int14Minor allele frequency- T:0.33WA CSA 125
    rs1925520701,2
    --58419809(+) AGGCCG/TGTGGC 1 -- int10--------
    rs735592191,2
    C,F--58419838(+) GTGCGA/GGAGGG 1 -- int13Minor allele frequency- G:0.21WA CSA 122
    rs1834191,2
    C,F,A,H--58420001(+) GAGGGT/CGGGGG 1 -- int120Minor allele frequency- C:0.18NS EA NA WA CSA 1936
    rs575476711,2
    C,F--58420020(+) GCCTGC/TAGAAG 1 -- int12Minor allele frequency- T:0.04WA 120
    rs1847781261,2
    --58420099(+) TGTAAA/CCCGCA 1 -- int10--------
    rs727868731,2
    C,F--58420273(+) TCTACC/TCGTCA 1 -- int11Minor allele frequency- T:0.03NA 120
    rs1883716931,2
    --58420275(+) TACCCA/GTCATG 1 -- int10--------
    rs6663011,2
    C,F--58420376(+) TAACCA/TTCCTA 1 -- int11Minor allele frequency- T:0.02NA 120
    rs71987961,2
    C,F--58420762(+) TGGGCT/GGGGGC 1 -- int12Minor allele frequency- G:0.36WA 120
    rs6681001,2
    C,F,A,H--58420792(+) GCGGAC/TAGTGA 1 -- int123Minor allele frequency- A:0.00EA NA NS WA CSA 2492
    rs1807867911,2
    --58420809(+) GAAAGC/TAGGGA 1 -- int10--------
    rs1117883531,2
    C--58420815(+) AGGGAG/TTCAGA 1 -- int10--------
    rs1485085941,2
    --58420825(+) ATGGCA/GGCTGC 1 -- int10--------
    rs1865018581,2
    --58420855(+) GTGACC/TGTGAG 1 -- int10--------
    rs735592251,2
    C,F--58420941(+) GGTGAC/TGAGGT 1 -- int12Minor allele frequency- T:0.05WA 120
    rs6820821,2
    C,F,A,H--58420957(+) TGCCTA/GTGGAG 1 -- int122Minor allele frequency- G:0.11EA NA NS WA CSA 2368
    rs1898197391,2
    --58421027(+) CCTAGA/GCTAGG 1 -- int10--------
    rs1438003481,2
    --58421047(+) GGACAC/TTGGGG 1 -- int10--------
    rs1819127181,2
    --58421053(+) TGGGGA/GACCCT 1 -- int10--------
    rs1869734441,2
    --58421203(+) CCAGGC/GTCACC 1 -- int10--------
    rs740195081,2
    C,F--58421207(+) GCTCAC/TCTTGG 1 -- int12Minor allele frequency- T:0.02WA 120
    rs1903336341,2
    --58421266(+) CCCCTA/GTAGGA 1 -- int10--------
    rs1472417121,2
    --58421541(+) CTCCTA/GTAGCC 1 -- int10--------
    rs767198701,2
    C--58421548(+) AGCCTA/TCCCGC 1 -- int10--------
    rs2238711,2
    C,F,H--58421807(+) ccctcA/Gaggtg 1 -- int110Minor allele frequency- G:0.34NS EA NA WA CSA 664
    rs1832846781,2
    --58421881(+) GGAAGA/GAGAAA 1 -- int10--------
    rs1508100101,2
    C--58421898(+) GTGAT-/AAAAAA 1 -- int10--------
    rs1146851501,2
    C,F--58421922(+) GGCTGG/AGCGCA 1 -- int11Minor allele frequency- A:0.05WA 118
    rs6835441,2
    C,F,A,H--58421924(+) ctgggT/Cgcagg 1 -- int17Minor allele frequency- C:0.38NA CSA 136
    rs1401539471,2
    C--58422010(+) CCTGGC/TCAACA 1 -- int10--------
    rs1393388091,2
    --58422025(+) GAAACA/CCTGTC 1 -- int10--------
    rs2238721,2
    C,F--58422050(+) aaaatT/Cagctg 1 -- int12Minor allele frequency- C:0.33NA CSA 3
    rs1449337341,2
    --58422147(+) GAGCCA/GAGATC 1 -- int10--------
    rs2016519441,2
    C--58422210(+) AAAAA-/AAGAAAGA 1 -- int10--------
    rs1130959061,2
    C--58422212(+) AAAAAG/AAAAGA 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1998084021,2
    --58422216(+) AAGAA-/AGAAAAG 1 -- int10--------
    rs1997554891,2
    --58422217(+) AGAAA-/GAAAAG 1 -- int10--------
    rs2238731,2
    C,A,H--58422418(-) aaaatG/Ttctct 1 -- int110Minor allele frequency- T:0.25WA NA CSA EA 370
    rs1703631,2
    C,F,H--58422492(+) ggccaG/Tagatg 1 -- int18Minor allele frequency- T:0.01NS EA NA 664
    rs99261861,2
    C--58422613(+) cagAAA/C/GTTAAA 1 -- int10--------
    rs1446220781,2
    C--58422792(+) AGTCTC/TCTTCT 1 -- int10--------
    rs1861364391,2
    C--58422825(+) AGTCCC/TTGAGG 1 -- int10--------
    rs1898215021,2
    --58422829(+) CTTGAA/GGTCCA 1 -- int10--------
    rs1466580911,2
    --58422957(+) TGGCAA/C/TCTAGG 1 -- int10--------
    rs1821491471,2
    --58423047(+) ATTTAA/GCCTCT 1 -- int10--------
    rs1881363331,2
    --58423064(+) TCCAGC/GTTCTG 1 -- int10--------
    rs1703641,2
    C,F,H--58423082(+) aaagtG/Tgggat 1 -- int131Minor allele frequency- T:0.28EA NA NS WA CSA 2805
    rs1404524291,2
    --58423103(+) TTGCAA/GGAATG 1 -- int10--------
    rs1146184861,2
    F--58423133(+) GATGTG/ATACAT 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1435974921,2
    --58423225(+) ACCTGC/TCCATC 1 -- int10--------
    rs1480366031,2
    --58423227(+) CTGTCC/TATCAG 1 -- int10--------
    rs620370821,2
    C,F--58423230(+) TCCATC/TAGGCT 1 -- int16Minor allele frequency- T:0.07WA NA CSA 246
    rs1176932861,2
    C,F--58423258(+) AGAGGC/TATTCC 1 -- int11Minor allele frequency- T:0.01NA 120
    rs770383481,2
    C,F--58423376(+) ATGGAA/GGCACT 1 -- int11Minor allele frequency- G:0.01NA 120
    rs1929049081,2
    --58423404(+) CAGTGA/CCTATG 1 -- int10--------
    rs1417104791,2
    C--58423534(+) TGGATA/GGATGG 1 -- int10--------
    rs1445961261,2
    C--58423568(+) GATGA-/ATGG  
            
    ATGGA
    1 -- int10--------
    rs1828094921,2
    --58423647(+) GGGATA/GGATGA 1 -- int10--------
    rs1887275451,2
    --58423657(+) AGTAGA/GTGAGA 1 -- int10--------
    rs1384259901,2
    --58423733(+) AGATGA/CATAGG 1 -- int10--------
    rs735592311,2
    C,F--58423794(+) GAGTGG/CGTGGA 1 -- int12Minor allele frequency- C:0.05WA 120
    rs735592361,2
    C,F--58423827(+) GATGCG/ATTAAA 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1439029691,2
    --58423970(+) ATATAA/TGACTG 1 -- int10--------
    rs1850259151,2
    --58423988(+) GAGGCA/GTTGTC 1 -- int10--------
    rs1894145281,2
    --58424128(+) GACTTC/TGGAGA 1 -- int10--------
    rs727868791,2
    C,F--58424146(+) ACTCTG/ATGGCT 1 -- int12Minor allele frequency- A:0.05NA EA 240
    rs735592371,2
    C,F--58424206(+) GAGCAC/TAGAAT 1 -- int12Minor allele frequency- T:0.04WA 120
    rs620370831,2
    C,F--58424280(+) GCACCG/ATATTT 1 -- int14Minor allele frequency- A:0.05WA NA 242
    rs1472580441,2
    --58424532(+) TTGATA/GACTCA 1 -- int10--------
    rs1915941761,2
    --58424579(+) AGCAGC/GGTGGG 1 -- int10--------
    rs1407049001,2
    C--58424774(+) CCAGGC/TTCTGA 1 -- int10--------
    rs1494341701,2
    --58424925(+) CTCCTC/TGAGCT 1 -- int10--------
    rs713871641,2
    C--58424926(+) TCCTTG/AAGCTC 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1448161511,2
    C--58424992(+) TTCAAC/TGTAAA 1 -- int10--------
    rs1485660861,2
    --58425045(+) TGTCCC/TGGGGT 1 -- int10--------
    rs1844697631,2
    C--58425066(+) TTCCAC/TGTGAC 1 -- int10--------
    rs1889955701,2
    --58425067(+) TCCACA/GTGACA 1 -- int10--------
    rs1429065021,2
    --58425126(+) ATACCA/GTCCAT 1 -- int10--------
    rs1510851091,2
    C--58425139(+) CCAACA/CCTCCT 1 -- int10--------
    rs7196951,2
    C,F--58425278(-) GTGGGG/TTCTGC 1 -- int12Minor allele frequency- T:0.06NA EA 240
    rs1727831,2
    C,F,A,H--58425348(+) ggcttG/Acatct 1 -- int19Minor allele frequency- A:0.28NA WA CSA 18
    rs1149268321,2
    F--58425402(+) CGGTCG/AGGGTT 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1398797391,2
    C--58425403(+) GGTCGA/GGGTTC 1 -- int10--------
    rs1432627481,2
    --58425426(+) GGCAAC/TATAGC 1 -- int10--------
    rs114899171,2
    C--58425530(+) TTTTTT/CCTTTT 1 -- int1 trp32Minor allele frequency- C:0.25NA WA 4
    rs114899181,2
    C--58425531(+) TTTTTC/TTTTTT 1 -- int1 trp31Minor allele frequency- T:0.50WA 2
    rs1813983351,2
    --58425617(+) CTCCCA/GGATTC 1 -- int10--------
    rs1862087541,2
    --58425633(+) ATTCTC/TCTGTC 1 -- int10--------
    rs1466769251,2
    --58425662(+) GGGACC/TAAAGG 1 -- int10--------
    rs1890120721,2
    --58425666(+) CTAAAA/GGTGCA 1 -- int10--------
    rs1402120131,2
    C--58425876(+) TTATAC/TCACTG 1 -- int10--------
    rs1503767441,2
    --58425879(+) TACCAC/TTGCAC 1 -- int10--------
    rs6716231,2
    C,F--58425950(+) TAAGGC/GAGAGG 1 -- int16Minor allele frequency- G:0.44NA CSA WA EA 364
    rs1450622641,2
    C--58425983(+) GGCCCA/GGTGGG 1 -- int10--------
    rs17877861,2
    C,F,A--58426113(+) cgggcC/Atggtg 1 -- int17Minor allele frequency- A:0.34NA WA CSA EA 366
    rs6458671,2
    C,F--58426124(+) gctcaC/Agcctg 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1125466011,2
    C,F--58426216(+) ACCCCG/ATCTCT 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1115441781,2
    C,F--58426278(+) CTATTC/TGGGAG 1 -- int12Minor allele frequency- T:0.50NA CSA 4
    rs1826661,2
    C,F--58426289(+) tctgaA/Ggcagg 1 -- int15Minor allele frequency- G:0.38NA WA CSA 8
    rs1464735461,2
    --58426300(+) AGAATC/TGCTTG 1 -- int10--------
    rs1390415831,2
    --58426301(+) GAATCA/GCTTGA 1 -- int10--------
    rs1414008231,2
    C--58426335(+) GAGCCA/GAGATC 1 -- int10--------
    rs1509095601,2
    --58426362(+) GCCTGA/GGCAAC 1 -- int10--------
    rs1814547251,2
    --58426367(+) GGCAAC/TAAGAG 1 -- int10--------
    rs709370301,2
    F--58426543(+) GGCAGG/AGGAGG 1 -- int11Minor allele frequency- A:0.05NA 40
    rs413891461,2
    C--58426679(+) GGAACC/TTCTTT 1 -- int11Minor allele frequency- T:0.02NA 42
    rs1864061261,2
    C--58426712(+) GTGACA/GAAATG 2 T syn10--------
    rs1496343211,2
    C--58426754(+) ATACCT/CGTAGC 2 /P syn11Minor allele frequency- C:0.00NA 4552
    rs620370841,2
    C,F--58426807(+) ACGCGC/TAATCA 2 A V mis12Minor allele frequency- T:0.01NA EU 5875
    rs1172701301,2
    C,F--58426822(+) GGTACT/CGCCCT 1 -- int12Minor allele frequency- C:0.00NA EU 1443
    rs2020390211,2
    --58426829(+) CCCTCA/GAGGCC 1 -- int10--------
    rs2022378571,2
    C--58426864(+) GAATAT/CTCCCA 1 -- int11Minor allele frequency- C:0.00EU 1321
    rs1908558871,2
    --58426887(+) TCTACG/TTCCAC 1 -- int10--------
    rs1401238061,2
    --58426898(+) ACCTCC/TGCTCC 1 -- int10--------
    rs1432788451,2
    --58427075(+) CAGCCA/GTGAAG 1 -- int10--------
    rs6702111,2
    C,F,A,H--58427148(+) GGGGCG/AGTGTG 1 -- int18Minor allele frequency- A:0.43NA CSA WA EA 370
    rs1461992051,2
    --58427172(+) CATGAA/GGGTCT 1 -- int10--------
    rs1391149281,2
    --58427301(+) AAAATA/GGGTAG 1 -- int10--------
    rs713871651,2
    C,F--58427434(+) CAACAC/TGGTGA 1 -- int12Minor allele frequency- T:0.50NA 4
    rs1509258591,2
    C--58427533(+) AATCGC/TTTGAA 1 -- int10--------
    rs64998781,2
    C,A--58427561(+) gcagtC/Gagcca 1 -- int10--------
    rs1827537571,2
    --58427621(+) CAAAAA/GAAAGA 1 -- int10--------
    rs1497432801,2
    --58427663(+) GCAGGG/TTGCTG 1 -- int10--------
    rs675887891,2
    C--58427719(+) AAACG-/AGACCAT 1 -- int10--------
    rs3679636851,2
    C--58427719(+) GAAACA/GACCAT 1 -- int10--------
    rs1860945471,2
    --58427737(+) CTTTGA/GGGAGG 1 -- int10--------
    rs1703611,2
    C,F,A,H--58427772(+) GTTGAG/AGACCC 1 -- int119Minor allele frequency- A:0.32NS EA NA WA CSA 2461
    rs1906497071,2
    --58427834(+) ACCAGC/TCAGCC 1 -- int10--------
    rs1181901291,2
    C,F--58427900(+) TAGAGG/CCCGGG 1 -- int11Minor allele frequency- C:0.03NA 120
    rs1833637571,2
    --58428163(+) TCCTGA/GACTTC 1 -- int10--------
    rs1870848731,2
    --58428180(+) TTCCCA/GGCATC 1 -- int10--------
    rs1907749191,2
    --58428219(+) TCTGAA/GCCTTG 1 -- int10--------
    rs1834201,2
    C,F--58428374(+) ACTAGC/TCACAC 1 -- int110Minor allele frequency- T:0.13EA NA MN WA CSA 478
    rs1412873651,2
    C--58428417(+) CGCTCA/GGGATC 1 -- int10--------
    rs1830177491,2
    --58428425(+) ATCCCA/GGTGAG 1 -- int10--------
    rs1466008681,2
    --58428499(+) GGCCCA/GGAGCA 1 -- int10--------
    rs1391083501,2
    --58428524(+) GAAACC/TGAAGG 1 -- int10--------
    rs1489516201,2
    C--58428591(+) CCATAC/GAGAGC 1 -- int10--------
    rs1164603071,2
    F--58428678(+) GTTATT/GATTTT 1 -- int11Minor allele frequency- G:0.03WA 118
    rs1880890411,2
    --58428701(+) ATCTAC/TTCTGA 1 -- int10--------
    rs753447011,2
    C,F--58428707(+) TCTGAG/CCTGGG 1 -- int12Minor allele frequency- C:0.07WA 120
    rs5965111,2
    C,F,A--58428711(-) AGCACC/GCAGCT 1 -- int19Minor allele frequency- G:0.28NA WA CSA EA 369
    rs735592491,2
    C,F--58428772(+) CGTCCG/CTGTTT 1 -- int12Minor allele frequency- C:0.07WA 120
    rs1436697381,2
    --58428784(+) CCTGGA/GGACTT 1 -- int10--------
    rs1167925081,2
    C--58428913(+) CCTGGA/GTGCTC 1 -- int10--------
    rs1151551391,2
    C--58428914(+) CTGGAA/TGCTCA 1 -- int10--------
    rs1116172401,2
    C,F--58428956(+) CTCACT/AGACGC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs620370851,2
    C,F--58428959(+) ACAGAC/TGCTAA 1 -- int13Minor allele frequency- T:0.03NA WA 122
    rs1137212631,2
    C--58428973(+) GGAGGA/GCAGGG 1 -- int12Minor allele frequency- G:0.07WA 120
    rs727868921,2
    C--58428988(+) CAGCCA/GGGTGT 1 -- int10--------
    rs774828721,2
    F--58429023(+) GTGCCC/TCCACA 1 -- int10--------
    rs2007753551,2
    C--58429041(+) GGCCCA/GGGTTT 1 -- int10--------
    rs1508471411,2
    F--58429151(+) AAGGAC/TGCGAT 2 D syn11Minor allele frequency- T:0.00NA 4486
    rs22291641,2
    C,F,H--58429154(+) GACGCG/AATGCA 2 /A syn1 ese313Minor allele frequency- A:0.02MN NS EA NA CSA WA 5696
    rs2000505061,2
    --58429170(+) TGGACA/CGCCAG 2 S R mis10--------
    rs1996096081,2
    C--58429172(+) GACCGC/TCAGGC 2 R syn10--------
    rs2016539431,2
    C--58429251(+) CTGCCG/ACCGGG 2 /T /A mis11Minor allele frequency- A:0.00EU 909
    rs1476697191,2
    C--58429254(+) CCGCCG/AGGGGA 2 /R /G mis11Minor allele frequency- A:0.00NA 3684
    rs1879208491,2
    C--58429280(+) GTCCTA/GGAGCC 2 L syn10--------
    rs2003540351,2
    C--58429318(+) GGAGCC/AGACTC 2 /Q /P mis11Minor allele frequency- A:0.00EU 701
    rs1389646881,2
    C--58429380(+) CGGGCA/GTGACT 2 M V mis10--------
    rs1998699861,2
    C,F--58429414(+) CCCGAC/TGCCAA 2 T M mis11Minor allele frequency- T:0.00EU 1099
    rs1922024491,2
    --58429469(+) CCTCCA/CGTCTC 2 P syn10--------
    rs1421136311,2
    C,F--58429475(+) GTCTCC/TACTGC 2 S syn12Minor allele frequency- T:0.01NA EU 5709
    rs1431453861,2
    C,F--58429523(+) CCCAGC/GCTCTG 2 S R mis12Minor allele frequency- G:0.00NA EU 5645
    rs2014473451,2
    --58429556(+) GCCCCA/GTCCAC 2 P syn10--------
    rs1385664691,2
    C,F--58429599(+) CCTCCC/TCAGCC 2 P S mis11Minor allele frequency- T:0.00NA 3978
    rs1462180291,2
    C,F--58429603(+) CCCAGC/ACCCAG 2 /D /A mis11Minor allele frequency- A:0.00NA 3934
    rs2005549571,2
    --58429609(+) CCCAGA/GGGAGA 2 E G mis10--------
    rs358600841,2,,4
    C,F--58429618(+) GAATGC/TTCCGT 2 A V mis14Minor allele frequency- T:0.00NA 4096
    rs1378863211,2
    C,F--58429621(+) TGCTCC/TGTCTG 2 P L mis12Minor allele frequency- T:0.00NA EU 4767
    rs1506907811,2
    C,F--58429636(+) CCAGCG/ATGTGT 2 /H /R mis11Minor allele frequency- A:0.00NA 4098
    rs1389680601,2
    C,F--58429679(+) TCTCTG/AGAGCG 2 /L syn11Minor allele frequency- A:0.00NA 4238
    rs1493982091,2
    C,F--58429695(+) AGATGG/AGTCCC 2 /S /G mis11Minor allele frequency- A:0.00NA 4286
    rs2014676741,2
    --58429714(+) GCACAC/TGGATG 2 T M mis10--------
    rs1499041061,2
    C--58429754(+) GCCCAC/TGTCTC 2 H syn11Minor allele frequency- T:0.00NA 4248
    rs129281121,2
    C,F,H--58429825(+) GACCCC/ATAAGG 2 /H /P mis1 ese37Minor allele frequency- A:0.01NS EA 1004
    rs129281171,2
    C,F,H--58429831(+) TAAGGC/ATGAGG 2 /D /A mis1 ese37Minor allele frequency- A:0.01NS EA NA 880
    rs1439015651,2
    C--58429875(+) TGGGCA/GTCCTT 2 I V mis10--------
    rs1486014591,2
    C--58429899(+) CTGACA/GCCCAG 2 T A mis10--------
    rs1454521351,2
    C,F--58429925(+) CAGGCG/AGTGGG 2 /A syn12Minor allele frequency- A:0.00NA EU 5715
    rs414670491,2
    C,F--58430018(+) ATGGCA/GGGAGA 2 A syn14Minor allele frequency- G:0.06NA CSA WA 4690
    rs1445232371,2
    C--58430029(+) GATGGC/TGGAGG 2 A V mis10--------
    rs2020072101,2
    C--58430041(+) CCTTCG/ACTACA 2 /H /R mis11Minor allele frequency- A:0.00EU 1323
    rs1160070891,2
    C,F--58430248(+) AGGCAT/CTCCCC 1 -- ut311Minor allele frequency- C:0.03WA 118
    rs41511171,2
    C,F,A,H--58430283(+) CACCTT/GCCAGG 1 -- ut31 ese333Minor allele frequency- G:0.29NA NS EA WA CSA 2987
    rs413427441,2
    C--58430355(+) TTAGAG/CGTTCC 1 -- ut311Minor allele frequency- C:0.02NA 46
    rs1131263091,2
    C,F--58430446(+) TACAGT/ACCTCC 1 -- ut312Minor allele frequency- A:0.06CSA WA 120
    rs1478434221,2
    --58430497(+) CCCTGC/TAACCT 1 -- ut310--------
    rs1413537471,2
    --58430610(+) TGACAC/TGTCTT 1 -- ut310--------
    rs709370331,2
    F--58430709(+) GGTATC/ATGGTG 1 -- ut311Minor allele frequency- A:0.15NA 40
    rs1452650111,2
    --58430846(+) TGACAA/TCACTC 1 -- ut310--------
    rs1816735141,2
    --58430889(+) ATGCAA/GCCTCA 1 -- ut310--------
    rs1476085311,2
    --58430904(+) CCTTAC/TCAGCA 1 -- ut310--------
    rs415338451,2
    C,F--58430979(+) TGCAAG/CGGAGT 1 -- ut312Minor allele frequency- C:0.04NA WA 162
    rs1405219641,2
    C--58431008(+) CTGCCC/TTGTGG 1 -- ut310--------
    rs22393501,2
    C,F--58431017(+) GGGCCC/GCCAAA 1 -- ut31 ese33Minor allele frequency- G:0.09NA EA 206
    rs22393511,2
    C,F,H--58431028(+) TGGAAA/GTGGGC 1 -- ut318Minor allele frequency- G:0.06NS EA NA WA 704
    rs1843159101,2
    --58431060(+) GGCCCC/TGCCCA 1 -- ut310--------
    rs2015497421,2
    --58431116(+) AAGAG-/GGAGGAGG 1 -- cds10--------
    rs1504262661,2
    C--58431247(+) ACACAC/TGCCAG 1 -- ut310--------
    rs670903711,2
    C--58431272(+) CTGGGC/G/TTCCCT 2 -- ut313NA CSA 155
    rs1381512201,2
    C--58431325(+) CAAGAA/CCTTCT 1 -- ut310--------
    rs22393521,2
    C,F,H--58431337(+) CTTCAC/TCTTTG 1 -- ut31 ese320Minor allele frequency- T:0.07EA NA NS 3718
    rs22393531,2
    C,F,H--58431426(+) CGGGAA/CGGGGG 1 -- ut31 trp38Minor allele frequency- C:0.08EA NS NA 2106
    rs1491257461,2
    C--58431585(+) TCCCCA/GACCCT 1 -- ut310--------
    rs1150954731,2
    C,F--58431702(+) GAGAGC/AAAGAC 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs786048921,2
    C,F--58431758(+) GTGGCG/ACAGCA 1 -- ut311Minor allele frequency- A:0.11EA 120
    rs83231,2
    C,F,A,H--58431831(-) ATTGGA/GCCCAC 1 -- ut31 ese331Minor allele frequency- G:0.30MN EA NA NS WA CSA 4410
    rs81021,2
    C,F,A,H--58431874(-) CCCTGA/GAAGGC 1 -- ut31 ese329Minor allele frequency- G:0.31MN NS EA NA WA CSA 3128
    rs414446501,2
    C,F--58431925(+) AAGCCA/C/GCTGGG 2 -- ut318NA WA CSA 293
    rs1451733691,2
    --58431983(+) ACATGA/GACAAG 1 -- ut310--------
    rs31779561,2
    C--58432022(+) AGGAAC/G/TACTTT 2 -- ut314NA CSA 125
    rs22393541,2
    C,F,H--58432136(+) CAAGTG/ACAGCA 1 -- int129Minor allele frequency- A:0.11EA NA NS WA CSA 4461
    rs1887489581,2
    --58432159(+) GAGGGA/GAAGGA 1 -- int10--------
    rs6436221,2
    C,F,A--58432176(+) CAGGGG/CTGGGG 1 -- int110Minor allele frequency- C:0.48EA NA WA CSA 1870
    rs6142301,2
    C,F,A,H--58432435(+) CCTGCC/TGAACC 1 -- int128Minor allele frequency- N:0.00NA EA NS WA CSA 3844
    rs1824526211,2
    --58432465(+) GACCAC/TTCTCA 1 -- int10--------
    rs1130224551,2
    C,F--58432514(+) TTCCTC/GTTTGT 1 -- int12Minor allele frequency- G:0.02NA 122
    rs1389974491,2
    --58432534(+) GGTTCA/CGATGA 1 -- int10--------
    rs1145781501,2
    C,F--58432578(+) GGAGTT/CCATAG 1 -- int11Minor allele frequency- C:0.03WA 118
    rs717745861,2
    ----58431962(+) TTGTT-/AGTTTCTC 1 -- cds10--------
    rs3693417601,2
    ----58426721(+) TGCAAC/TATCAC 2 N syn10--------
    rs3719052831,2
    ----58429569(+) AGGACA/CCCTCC 2 T P mis10--------
    rs595027571,2
    ----58422211(+) AAAAA-/A/AG  
            
    GAAAG
    1 -- int10--------
    rs3721291551,2
    ----58427343(+) AGGGCA/GCGGTG 1 -- int10--------
    rs569968141,2
    ----58422215(+) AAAGAA/GAGAAA 1 -- int10--------
    rs3752851991,2
    ----58417717(+) AATGTC/TTTTTT 1 -- us2k10--------
    rs353506501,2
    ----58422520(+) TACCC-/GGGGAC 1 -- int10--------
    rs3724249771,2
    ----58418603(+) GTGCTA/GGGAAG 1 -- us2k10--------
    rs3761726001,2
    ----58423500(+) GGAAG-/TGGA  
            
    TGGAT
    1 -- int10--------
    rs1487701181,2
    ----58426796(+) TCATGC/TGGCAA 2 C syn11Minor allele frequency- T:0.00EU 1323
    rs3684402451,2
    ----58425611(+) CTCTGA/CCTCCC 1 -- int10--------
    rs106834661,2
    ----58417737(+) TTTTT-/TT/TTT
            
    AGACA
    2 -- us2k1 cds10--------
    rs3772377131,2
    ----58419693(+) TGCTGG/TCTGGT 2 A S mis10--------
    rs3763502781,2
    ----58429250(+) CCTGCC/TGCCGG 2 A syn10--------
    rs1996629061,2
    ----58430053(+) CCCCCG/AGAGCT 2 /Q /R mis11Minor allele frequency- A:0.00EU 1323
    rs799260921,2
    ----58428777(+) GTGTTG/TGCCTG 1 -- int11Minor allele frequency- T:0.50NA 2
    rs3736827591,2
    ----58429160(+) ATGCAA/GCATCT 2 Q syn10--------
    rs1999438581,2
    ----58423501(+) GGAAG-/TGG   
       ATGGA
    TGGAT
    1 -- int10--------
    rs607722171,2
    ----58422198(+) CATTTA/TAAAAA 1 -- int10--------
    rs3713618761,2
    ----58419220(+) TTCCAC/TGCCTG 1 -- us2k10--------
    rs3680152051,2
    ----58429563(+) CCACCC/GAGGAC 2 Q E mis10--------
    rs3713210291,2
    ----58417906(+) GAGACA/GAGGTT 1 -- us2k10--------
    rs3688129651,2
    ----58425994(+) GACTAG/TGCAGG 1 -- int10--------
    rs3731153851,2
    ----58429298(+) ACAGGC/TGAAAG 2 G syn10--------
    rs2008031341,2
    ----58418297(+) GGGGGC/GGGGGG 1 -- us2k10--------
    rs3717860071,2
    ----58423788(+) TGATAA/TAGTGG 1 -- int10--------
    rs562028161,2
    ----58423551(+) GATGG-/ATGG  
            
    GTGGA
    1 -- int10--------
    rs3753157571,2
    ----58429223(+) ATCGGC/TGAGGT 2 G syn10--------
    rs354112011,2
    ----58419983(+) AGGTG-/TTGGGT 1 -- int10--------
    rs3761294811,2
    ----58423562(+) TAGATA/GGATGA 1 -- int10--------
    rs3699055521,2
    ----58430115(+) TCTAGC/TTGTTT 1 -- ut310--------
    rs3771661311,2
    ----58430052(+) TCCCCC/TGGAGC 2 R W mis10--------
    rs3683385661,2
    ----58429952(+) GGCCTC/TCTCTT 2 L syn10--------
    rs3768714601,2
    ----58428182(+) CCCGGC/TTCCTG 1 -- int10--------
    rs3713784981,2
    ----58425859(+) GTTGCC/TGTGAG 1 -- int10--------
    rs2000519751,2
    ----58429221(+) AGATCG/TGCGAG 2 G C mis11Minor allele frequency- T:0.00EU 1207
    rs3742565271,2
    ----58429970(+) GGGGTA/GGCCAT 2 V syn10--------
    rs3720625641,2
    ----58424510(+) CTGAAA/GTACTA 1 -- int10--------
    rs3770758111,2
    ----58418222(+) GTTCCA/GCTACT 1 -- us2k10--------
    rs3748541391,2
    ----58429438(+) AGGGCC/TTGTGG 2 P L mis10--------
    rs770222681,2
    ----58426215(+) AACCCG/CGTCTC 1 -- int11Minor allele frequency- C:0.50NA 2
    rs1400086461,2
    ----58429152(+) AGGACG/ACGATG 2 /T /A mis11Minor allele frequency- A:0.00NA 4476
    rs709370341,2
    ----58431337(+) TTCANC/TTTTGT 2 -- ut311Minor allele frequency- T:0.03NA 38
    rs1116770571,2
    ----58427114(+) ATGTTG/ACCCCA 1 -- int11Minor allele frequency- A:0.33CSA 3
    rs1384604211,2
    ----58426703(+) CACCAC/TGGTGT 2 H syn11Minor allele frequency- T:0.00NA 4552
    rs3774535481,2
    ----58421969(+) CAAGGC/TGGCAG 1 -- int10--------
    rs743717051,2
    ----58429301(+) GGCGAA/CAGCAG 2 E D mis10--------
    rs3709332061,2
    ----58428927(+) AGAGCA/GGGTTG 1 -- int10--------
    rs3710521811,2
    ----58423501(+) GGAAG-/TGGA  
            
    TGGAT
    1 -- int10--------
    rs3761066651,2
    ----58429652(+) CAGGGA/GCAGAG 2 G syn10--------
    rs3752917441,2
    ----58421555(+) CCGCCC/TATTAG 1 -- int10--------
    rs129177531,2
    ----58419371(+) CAAGCA/CTAGGA 1 -- us2k10--------
    rs3747888581,2
    ----58426792(+) GGCATC/TATGCG 2 S L mis10--------
    rs3729758371,2
    ----58418404(+) GGTTTC/GCTCAG 1 -- us2k10--------
    rs3729682241,2
    ----58426036(+) GACCTC/TGCAGG 1 --