Aliases for CX3CL1 Gene
Aliases for CX3CL1 Gene
External Ids for CX3CL1 Gene
- HGNC: 10647
- Entrez Gene: 6376
- Ensembl: ENSG00000006210
- OMIM: 601880
- UniProtKB: P78423
Previous HGNC Symbols for CX3CL1 Gene
- SCYD1
Previous GeneCards Identifiers for CX3CL1 Gene
- GC16P047801
- GC16P057466
- GC16P057140
- GC16P057181
- GC16P057162
- GC16P055963
- GC16P057406
- GC16P043274
Summaries for CX3CL1 Gene
-
This gene belongs to the CX3C subgroup of chemokines, characterized by the number of amino acids located between the conserved cysteine residues. This is the only member of the CX3C subgroup, which contains three amino acids between cysteine residues, resulting in a Cys-X-X-X-Cys configuration. The encoded protein contains an extended mucin-like stalk with a chemokine domain on top, and exists in both a membrane-anchored form where it acts as a binding molecule, or, in soluble form, as a chemotactic cytokine. The mature form of this protein can be cleaved at the cell surface, yielding different soluble forms that can interact with the G-protein coupled receptor, C-X3-C motif chemokine receptor 1 gene product. This gene plays a role in a wide range of diseases, including cancer, vasculitis, neuropathies, atherosclerosis, inflammatory diseases, and in human immunodeficiency virus infections. [provided by RefSeq, Sep 2017]
GeneCards Summary for CX3CL1 Gene
CX3CL1 (C-X3-C Motif Chemokine Ligand 1) is a Protein Coding gene. Diseases associated with CX3CL1 include Pityriasis Rosea and Chorioretinitis. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include receptor binding and chemokine activity.
UniProtKB/Swiss-Prot for CX3CL1 Gene
-
Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1 (PubMed:23125415, PubMed:9931005, PubMed:21829356). Binds to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (PubMed:23125415, PubMed:24789099). The soluble form is chemotactic for T-cells and monocytes and not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium (PubMed:9024663, PubMed:9177350).
Additional gene information for CX3CL1 Gene
- Monarch Initiative
- Search for CX3CL1 at DataMed
- Search for CX3CL1 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CX3CL1 Gene
Genomics for CX3CL1 Gene
GeneHancer (GH) Regulatory Elements for CX3CL1 Gene
Promoters and enhancers for CX3CL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CX3CL1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CX3CL1 gene promoter:
Regulatory Element Products
Genomic Locations for CX3CL1 Gene
Genomic Locations for CX3CL1 Gene
- chr16:57,372,458-57,385,048
- (GRCh38/hg38)
- Size:
- 12,591 bases
- Orientation:
- Plus strand
- chr16:57,406,370-57,418,960
- (GRCh37/hg19)
Genomic View for CX3CL1 Gene
Genes around CX3CL1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q21 by Ensembl
- 16q21 by Entrez Gene
- 16q21 by HGNC
CX3CL1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CX3CL1 Gene
Proteins for CX3CL1 Gene
-
Protein details for CX3CL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P78423-X3CL1_HUMAN
- Recommended name:
- Fractalkine
- Protein Accession:
- P78423
- O00672
Protein attributes for CX3CL1 Gene
- Size:
- 397 amino acids
- Molecular mass:
- 42203 Da
- Quaternary structure:
-
- Monomer (PubMed:9931005). Interacts with pox virus crmD; this inhibits cell migration mediated by CX3CL1 (PubMed:21829356). Forms a ternary complex with CX3CR1 and ITGAV:ITGB3 or ITGA4:ITGB1 (PubMed:23125415).
Protein Expression for CX3CL1 Gene
Post-translational modifications for CX3CL1 Gene
- A soluble short 95 kDa form may be released by proteolytic cleavage from the long membrane-anchored form.
- O-glycosylated with core 1 or possibly core 8 glycans.
- Glycosylation at Asn33, posLast=183183, Ser253, Thr318, and posLast=329329
Other Protein References for CX3CL1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CX3CL1 (CX3CL1/Fractalkine)
- Novus Biologicals Antibodies for CX3CL1
-
Abcam antibodies for CX3CL1
-
Cloud-Clone Corp. Antibodies for CX3CL1
- Invitrogen Antibodies for CX3CL1
- antibodies-online: Search results for 273 available CX3CL1 Antibodies ranked by validation data
- Compare Top CX3CL1 Antibodies
-
Recommended
- 48 WB Antibodies (anti-mouse)
- 1 CC Antibody (anti-human)
- 2 Neut Antibodies (anti-human)
- 2 IHC (fro) Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 15 IHC (p) Antibodies (anti-human)
- 37 FACS Antibodies (anti-human)
- 144 WB Antibodies (anti-human)
- 1 IHC (fro) Antibody (anti-rat)
- 1 FACS Antibody (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 29 WB Antibodies (anti-rat)
- 1 IHC (fro) Antibody (anti-mouse)
- 4 FACS Antibodies (anti-mouse)
- 5 IHC Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 13 IHC (p) Antibodies (anti-mouse)
- GeneTex CX3CL1 antibody for CX3CL1
-
Custom Antibody ServicesProSci Antibodies for CX3CL1
-
Santa Cruz Biotechnology (SCBT) Antibodies for CX3CL1
- Sino Biological Antibodies for CX3CL1
Protein Products
- R&D Systems Proteins and Enzymes for CX3CL1 (CX3CL1/Fractalkine)
-
OriGene Purified Proteins for CX3CL1
- Search Origene for MassSpec and Protein Over-expression Lysates for CX3CL1
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- Novus Biologicals proteins for CX3CL1
- Sino Biological Cell Lysates for CX3CL1
- Sino Biological Recombinant Proteins for CX3CL1
- ProSpec Recombinant Proteins for CX3CL1
-
Cloud-Clone Corp. Proteins for CX3CL1
- GeneTex Proteins for CX3CL1
-
Abcam proteins for CX3CL1
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for CX3CL1
- R&D Systems Proteome Profiler Antibody Arrays, Luminex Assays, ELISAs, and other biochemical assays for CX3CL1 (CX3CL1/Fractalkine)
-
Abcam assays for CX3CL1
- Sino Biological Assays for CX3CL1
No data available for DME Specific Peptides for CX3CL1 Gene
Domains & Families for CX3CL1 Gene
Gene Families for CX3CL1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for CX3CL1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CX3CL1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P78423- Family:
-
- Belongs to the intercrine delta family.
Function for CX3CL1 Gene
Molecular function for CX3CL1 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1 (PubMed:23125415, PubMed:9931005, PubMed:21829356). Binds to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (PubMed:23125415, PubMed:24789099). The soluble form is chemotactic for T-cells and monocytes and not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium (PubMed:9024663, PubMed:9177350).
- UniProtKB/Swiss-Prot Induction:
- By TNF and IL1/interleukin-1 in pulmonary endothelial cells and umbilical vein endothelial cells.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | receptor binding | TAS | 12714508 |
| GO:0005125 | cytokine activity | IEA | -- |
| GO:0005178 | integrin binding | IDA | 23125415 |
| GO:0005515 | protein binding | IPI | 9931005 |
| GO:0008009 | chemokine activity | IEA,TAS | 12714508 |
Phenotypes for CX3CL1 Gene
- MGI mutant phenotypes for CX3CL1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CX3CL1:
-
- Increased vaccinia virus (VACV) infection
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Dynamic nuclei (hole, folded or small irregular)
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Increased circadian period length
- Decreased viability of wild-type and TP53 knockout cells
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CX3CL1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CX3CL1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CX3CL1 gene
- Search ViGene Biosciences for CX3CL1
CRISPR Products
-
OriGene CRISPR knockouts for CX3CL1
- genomics-online: gRNA clones - Search results for 242 available CX3CL1 gene related products
- Overview of 242 available CX3CL1 gene related products
- Applied Biological Materials CRISPR for CX3CL1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CX3CL1
- GenScript: Design CRISPR guide RNA sequences for CX3CL1
miRNA for CX3CL1 Gene
- miRTarBase miRNAs that target CX3CL1
-
- bta-mir-17-5p (MIRT053857)
- hsa-mir-5093 (MIRT725020)
- hsa-mir-7152-3p (MIRT725021)
- hsa-mir-6791-5p (MIRT725022)
- hsa-mir-4292 (MIRT725023)
- hsa-mir-4308 (MIRT725024)
- hsa-mir-490-5p (MIRT725025)
- hsa-mir-3688-3p (MIRT725026)
- hsa-mir-2681-3p (MIRT725027)
- hsa-mir-605-5p (MIRT725028)
- hsa-mir-27b-3p (MIRT732890)
miRNA Products
- Search ViGene Biosciences for CX3CL1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CX3CL1
- Browse OriGene Inhibitory RNA Products For CX3CL1
- genomics-online: shRNA clones - Search results for 242 available CX3CL1 gene related products
- Overview of 242 available CX3CL1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CX3CL1 gene
Clone Products
- Sino Biological Human cDNA Clone for CX3CL1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CX3CL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CX3CL1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for CX3CL1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CX3CL1 (CX3CL1/Fractalkine)
Cell Line Products
-
Horizon Cell Lines for CX3CL1
-
ViGene Biosciences adenoviral particle packaged cDNA for CX3CL1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CX3CL1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CX3CL1 gene
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CX3CL1 Gene
Localization for CX3CL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CX3CL1 Gene
- Cell membrane; Single-pass type I membrane protein.
- Processed fractalkine: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| cytosol | 1 |
| lysosome | 1 |
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IDA,IEA | 12714508 |
| GO:0005615 | extracellular space | IBA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0009986 | cell surface | IDA,IEA | 12714508 |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for CX3CL1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
.61
.47
|
|
| 2 | ERK Signaling |
.61
|
|
| 3 | Peptide ligand-binding receptors | ||
| 4 | CCR5 Pathway in Macrophages | ||
| 5 | Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions | ||
Pathways by source for CX3CL1 Gene
1 BioSystems pathway for CX3CL1 Gene
6 Reactome pathways for CX3CL1 Gene
3 KEGG pathways for CX3CL1 Gene
2 R&D Systems pathways for CX3CL1 Gene
17 Qiagen pathways for CX3CL1 Gene
Interacting Proteins for CX3CL1 Gene
Selected Interacting proteins:
P78423-X3CL1_HUMAN
ENSP00000006053
for CX3CL1 Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002523 | leukocyte migration involved in inflammatory response | IMP | 23125415 |
| GO:0002548 | monocyte chemotaxis | IBA | -- |
| GO:0006935 | chemotaxis | IMP | 23125415 |
| GO:0006952 | defense response | TAS | 12714508 |
| GO:0006955 | immune response | TAS,IEA | 12714508 |
Transcripts for CX3CL1 Gene
mRNA/cDNA for CX3CL1 Gene
- (2) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (192) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CX3CL1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CX3CL1
- genomics-online: gRNA clones - Search results for 242 available CX3CL1 gene related products
- Overview of 242 available CX3CL1 gene related products
- Applied Biological Materials CRISPR for CX3CL1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CX3CL1
- GenScript: Design CRISPR guide RNA sequences for CX3CL1
miRNA Products
- Search ViGene Biosciences for CX3CL1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CX3CL1
- Browse OriGene Inhibitory RNA Products For CX3CL1
- genomics-online: shRNA clones - Search results for 242 available CX3CL1 gene related products
- Overview of 242 available CX3CL1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CX3CL1 gene
Clone Products
- Sino Biological Human cDNA Clone for CX3CL1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CX3CL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CX3CL1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for CX3CL1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CX3CL1 (CX3CL1/Fractalkine)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: | - |
Expression for CX3CL1 Gene
mRNA differential expression in normal tissues according to GTEx for CX3CL1 Gene
This gene is overexpressed in Breast - Mammary Tissue (x4.4).
This gene is overexpressed in Bone (57.4) and Heart (10.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CX3CL1 Gene
NURSA nuclear receptor signaling pathways regulating expression of CX3CL1 Gene:
CX3CL1SOURCE GeneReport for Unigene cluster for CX3CL1 Gene:
Hs.531668mRNA Expression by UniProt/SwissProt for CX3CL1 Gene:
P78423-X3CL1_HUMAN
Tissue specificity:
Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level). Small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and pancreas. Most abundant in the brain and heart.
Evidence on tissue expression from TISSUES for CX3CL1 Gene
- Nervous system(4.9)
- Lung(2.9)
- Heart(2.6)
- Blood(2.5)
- Kidney(2.3)
- Muscle(2.3)
- Lymph node(2)
Primer Products
-
OriGene qPCR primer pairs for CX3CL1
-
OriGene qPCR primer pairs and template standards for CX3CL1
- genomics-online: primer clones - Search results for 242 available CX3CL1 gene related products
- Overview of 242 available CX3CL1 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CX3CL1 Gene
Orthologs for CX3CL1 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CX3CL1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | CX3CL1 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cx3cl1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Cx3cl1 33 16 34 |
|
||
| cow (Bos Taurus) |
Mammalia | CX3CL1 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CX3CL1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CX3CL1 34 |
|
OneToOne |
- Species where no ortholog for CX3CL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for CX3CL1 Gene
(17) SIMAP similar genes for CX3CL1 Gene using alignment to 6 proteins:
No data available for Paralogs for CX3CL1 Gene
Variants for CX3CL1 Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000237648 | -- | 57,382,973(+) | G/T | coding_sequence_variant, missense_variant | |
| rs1000511047 | -- | 57,372,054(+) | A/C | upstream_transcript_variant | |
| rs1000542233 | -- | 57,372,177(+) | T/C | upstream_transcript_variant | |
| rs1000836186 | -- | 57,377,510(+) | A/G | intron_variant | |
| rs1001847255 | -- | 57,383,629(+) | G/A | 3_prime_UTR_variant |
Residual Variation Intolerance Score:
58.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.08;
22.06% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CX3CL1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CX3CL1 Gene
Disorders for CX3CL1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pityriasis rosea |
|
|
| chorioretinitis |
|
|
| vasculitis |
|
|
| listeria meningitis |
|
|
| rheumatoid vasculitis |
|
|
Search CX3CL1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CX3CL1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CX3CL1 Gene
Publications for CX3CL1 Gene
- A new class of membrane-bound chemokine with a CX3C motif. (PMID: 9024663) Bazan JF … Schall TJ (Nature 1997) 2 3 4 22 58
- Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation. (PMID: 9177350) Pan Y … Gearing D (Nature 1997) 2 3 4 22 58
- Fractalkine receptor/ligand genetic variants and carotid intima-media thickness. (PMID: 19372452) Debette S … Markus HS (Stroke 2009) 3 22 44 58
- Polymorphisms of Fractalkine receptor CX3CR1 and plasma levels of its ligand CX3CL1 in colorectal cancer patients. (PMID: 17611763) Dimberg J … Wågsäter D (International journal of colorectal disease 2007) 3 22 44 58
- Solution structure and dynamics of the CX3C chemokine domain of fractalkine and its interaction with an N-terminal fragment of CX3CR1. (PMID: 9931005) Mizoue LS … Handel TM (Biochemistry 1999) 3 4 22 58
Products for CX3CL1 Gene
- R&D Systems Antibodies for CX3CL1 (CX3CL1/Fractalkine)
- R&D Systems Proteins and Enzymes for CX3CL1 (CX3CL1/Fractalkine)
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for CX3CL1 (CX3CL1/Fractalkine)
- R&D Systems cDNA Clones for CX3CL1 (CX3CL1/Fractalkine)
- Browse Primary Antibodies
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- Browse Activity Assays
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- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
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- Browse Immunoprecipitation Assays
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CX3CL1
- Custom Assay ServicesOriGene ELISA Kits for CX3CL1
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- Browse OriGene Inhibitory RNA Products For CX3CL1
- OriGene qPCR primer pairs and template standards for CX3CL1
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- CloneReady with Over 120,000 Genes
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- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CX3CL1
- Sino Biological Human cDNA Clone for CX3CL1
- Sino Biological Cell Lysates for CX3CL1
- Sino Biological Recombinant Proteins for CX3CL1
- Sino Biological Antibodies for CX3CL1
- Sino Biological Assays for CX3CL1
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for CX3CL1
- Novus Biologicals proteins for CX3CL1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for CX3CL1
- Abcam proteins for CX3CL1
- Abcam assays for CX3CL1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for CX3CL1
- Cloud-Clone Corp. Antibodies for CX3CL1
- Cloud-Clone Corp. Proteins for CX3CL1
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for CX3CL1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for CX3CL1
- VectorBuilder custom plasmid, inducible vectors for CX3CL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CX3CL1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 273 available CX3CL1 Antibodies ranked by validation data
- Compare Top CX3CL1 Antibodies
- Recommended
- 48 WB Antibodies (anti-mouse)
- 13 IHC (p) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 5 IHC Antibodies (anti-mouse)
- 4 FACS Antibodies (anti-mouse)
- 1 IHC (fro) Antibody (anti-mouse)
- 29 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- 1 IHC (fro) Antibody (anti-rat)
- 144 WB Antibodies (anti-human)
- 37 FACS Antibodies (anti-human)
- 15 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 2 IHC (fro) Antibodies (anti-human)
- 2 Neut Antibodies (anti-human)
- 1 CC Antibody (anti-human)
- antibodies-online: Search results for 86 available CX3CL1 Elisa Kits ranked by validation data
- Compare Top CX3CL1 Elisa Kits
- antibodies-online: Search results for 73 available CX3CL1 Proteins ranked by validation data
- Compare Top CX3CL1 Proteins
- GeneTex CX3CL1 antibody for CX3CL1
- GeneTex Proteins for CX3CL1
- ViGene Biosciences adenoviral particle packaged cDNA for CX3CL1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CX3CL1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CX3CL1 gene
- Search ViGene Biosciences for CX3CL1
- Santa Cruz Biotechnology (SCBT) Antibodies for CX3CL1
- Search Santa Cruz Biotechnology (SCBT) for CX3CL1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CX3CL1
- Custom Antibody ServicesProSci Antibodies for CX3CL1
- Horizon Cell Lines for CX3CL1
- genomics-online: cdna clones - Search results for 242 available CX3CL1 gene related products
- Overview of 242 available CX3CL1 gene related products
- orf clones - Search results for 242 available CX3CL1 gene related products
- Overview of 242 available CX3CL1 gene related products
- genomics-online: gRNA clones - Search results for 242 available CX3CL1 gene related products
- Overview of 242 available CX3CL1 gene related products
- genomics-online: primer clones - Search results for 242 available CX3CL1 gene related products
- Overview of 242 available CX3CL1 gene related products
- genomics-online: shRNA clones - Search results for 242 available CX3CL1 gene related products
- Overview of 242 available CX3CL1 gene related products
Sources for CX3CL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew