Aliases for CX3CL1 Gene
External Ids for CX3CL1 Gene
Previous HGNC Symbols for CX3CL1 Gene
Previous GeneCards Identifiers for CX3CL1 Gene
GeneCards Summary for CX3CL1 Gene
CX3CL1 (C-X3-C Motif Chemokine Ligand 1) is a Protein Coding gene. Diseases associated with CX3CL1 include Tauopathy and Rheumatoid Vasculitis. Among its related pathways are PEDF Induced Signaling and Signaling by GPCR. GO annotations related to this gene include receptor binding and chemokine activity.
UniProtKB/Swiss-Prot for CX3CL1 Gene
Acts as a ligand for both CX3CL1 and integrins. Binds to CX3CR1 (PubMed:23125415, PubMed:9931005, PubMed:21829356). Binds to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (PubMed:23125415, PubMed:24789099). The soluble form is chemotactic for T-cells and monocytes and not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium (PubMed:9024663, PubMed:9177350).