CWH43 Gene
protein-coding GIFtS: 39
GCID: GC04P048988
|
|
cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)
| |
Aliases
for CWH43 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cell Wall Biogenesis 43 C-Terminal Homolog (S. Cerevisiae)1 2 | | CWH43-C1 2 | | Cell Wall Biogenesis Protein 43 C-Terminal Homolog2 3 | | FLJ215111 | | PGAP2-Interacting Protein2 | | PGAP2IP3 |
Export aliases for CWH43 gene to outside databasesPrevious GC identifers: GC04P048684 GC04P048308 |
Summaries
for CWH43 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: PG2IP_HUMAN, Q9H720Function: Involved in lipid remodeling during GPI-anchor maturation (By similarity)
|
Genomic Views
for CWH43 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_006238.11
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CWH43
Other transcription factors
Search SABiosciences Chromatin IP Primers for CWH43
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CWH43 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p11 Ensembl cytogenetic band: 4p11 HGNC cytogenetic band: 4p12-p11CWH43 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P048988: view genomic region
(about GC identifiers)
Start:
|
48,988,264 bp from pter |
End:
|
49,064,098 bp from pter |
Size:
|
75,835 bases |
Orientation:
|
plus strand |
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Proteins
for CWH43 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PG2IP_HUMAN, Q9H720 (See
protein sequence)Recommended Name: PGAP2-interacting protein Size: 699 amino acids; 78584 Da
Subunit: Interacts with PGAP2/FRAG1 (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B2RPD7Explore the universe of human proteins at neXtProt for CWH43: NX_Q9H720
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H720
CWH43 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079363.2
ENSEMBL proteins: ENSP00000226432 ENSP00000425157 ENSP00000422802
Human Recombinant Protein Products for CWH43:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
CWH43 for ontologies About GeneDecksing
CWH43 Antibody Products:
Assay Products for CWH43: |
Protein
Domains /
Families
for CWH43 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CWH43 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H720ProtoNet protein and cluster: Q9H720 UniProtKB/Swiss-Prot: PG2IP_HUMAN, Q9H720Similarity: Belongs to the PGAP2IP family |
Function
for CWH43 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: PG2IP_HUMAN, Q9H720Function: Involved in lipid remodeling during GPI-anchor maturation (By similarity)Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CWH43 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CWH43
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CWH43 (NM_025087) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CWH43 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CWH43 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CWH43 |
|
Pathways & Interactions
for CWH43 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CWH43
5/22 Interacting proteins for CWH43 (Q9H7203) via UniProtKB, MINT, STRING, and/or I2D (see all 22)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006506 | GPI anchor biosynthetic process |
IEA | -- |
CWH43 for ontologies About GeneDecksing
|
Drugs & Compounds
for CWH43 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CWH43
Search CenterWatch for drugs/clinical trials and news about CWH43 / PG2IP
|
Transcripts
for CWH43 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CWH43 gene: NM_025087.2 Unigene Cluster for CWH43: Cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) Hs.479703 [show with all ESTs]Unigene Representative Sequence: AK0251645 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000226432(uc003gyv.3) ENST00000514053 ENST00000513409(uc011bzl.2)
ENST00000506221 ENST00000507372
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CWH43 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CWH43
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CWH43 (NM_025087) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CWH43 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CWH43 |
Additional cDNA sequence: AK025164.1 AK300495.1 AK316307.1 BC137387.1 BC137388.1 1 DOTS entry: DT.75101082 21 AceView cDNA sequences: AI377551 AA863019 AA195718 BX954769 AI812045 BQ954070 AK025164 BG696417 NM_025087 AW572339 AI962905 AA369925 AI373245 AI868470 AI826824 AW235545 BG193159 AW589434 AA195754 BI001197 BE180939
GeneLoc Exon Structure
|
Expression
for CWH43 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CWH43 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGAACCTCA
About this image
See CWH43 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CWH43
SOURCE GeneReport for Unigene cluster: Hs.479703
SABiosciences Custom PCR Arrays for CWH43
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CWH43
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CWH43 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CWH43 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CWH43 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CWH43 |
Orthologs
for CWH43 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals and fungi.
Orthologs for CWH43 gene from 3/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Cwh431 , 5 |
cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)1, 5 |
82.4(n)1
82.98(a)1 |
|
5 (38.78 cM)5
2312931 NM_181323.21 NP_851840.11
734060765 |
chicken
(Gallus gallus) |
Aves |
CWH431 |
cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) |
70.73(n)
67.86(a) |
|
422763 XM_420716.3 XP_420716.3 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
CWH43(YCR017C)4
CWH431 |
Putative sensor/transporter protein involved in cell more4
Cwh43p1 |
43.17(n)1
31.96(a)1 |
|
3(147634-144773)4
8503761, 4 NP_009943.21, 4 |
ENSEMBL Gene Tree for CWH43 (if available)
TreeFam Gene Tree for CWH43 (if available) |
Paralogs
for CWH43 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CWH43 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 4 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CWH43 (48988264 - 49064098 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CWH43
3 CNVs: 39364 38558 3493 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CWH43 |
|
Disorders
/ Diseases
for CWH43 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for CWH43 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CWH43 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CWH43) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Saccharomyces cerevisiae CWH43 is involved in the rem odeling of the lipid moiety of GPI anchors to ceramides. (PubMed id 17761529)1, 3 Umemura M....Jigami Y. (2007)
- CWH43 is required for the introduction of ceramides i nto GPI anchors in Saccharomyces cerevisiae. (PubMed id 17714445)1, 3 Ghugtyal V....Conzelmann A. (2007)
- Serum ferritin levels are associated with a distinct p henotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy. (PubMed id 22095909)1 Lange C.M....Bochud P.Y. (2012)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for CWH43 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CWH43 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CWH43 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CWH43 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CWH43 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CWH43 gene:
Search GeneIP for patents involving CWH43
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CWH43 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CWH43 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CWH43 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CWH43 | | | OriGene Protein Over-expression Lysate for CWH43 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CWH43 | | OriGene 3'-UTR Clone for CWH43 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CWH43 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CWH43 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CWH43 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CWH43 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CWH43 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CWH43 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CWH43 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CWH43 |
| |
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| | | | Search Tocris compounds for CWH43 |
| |  |  |  |  | | | | |
 |
 |
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 | | | CWH43 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CWH43 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for CWH43 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CWH43 |
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