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Aliases for CWH43 Gene

Aliases for CWH43 Gene

  • Cell Wall Biogenesis 43 C-Terminal Homolog 2 3 5
  • Cell Wall Biogenesis Protein 43 C-Terminal Homolog 3 4
  • Cell Wall Biogenesis 43 C-Terminal Homolog (S. Cerevisiae) 2
  • CWH43-C 3
  • PGAP2IP 4

External Ids for CWH43 Gene

Previous GeneCards Identifiers for CWH43 Gene

  • GC04P048684
  • GC04P048308

Summaries for CWH43 Gene

GeneCards Summary for CWH43 Gene

CWH43 (Cell Wall Biogenesis 43 C-Terminal Homolog) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CWH43 Gene

  • Involved in lipid remodeling during GPI-anchor maturation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CWH43 Gene

Genomics for CWH43 Gene

Genomic Location for CWH43 Gene

Chromosome:
4
Start:
48,986,247 bp from pter
End:
49,062,081 bp from pter
Size:
75,835 bases
Orientation:
Plus strand

Genomic View for CWH43 Gene

Genes around CWH43 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CWH43 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CWH43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CWH43 Gene

No data available for Regulatory Elements for CWH43 Gene

Proteins for CWH43 Gene

  • Protein details for CWH43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H720-PG2IP_HUMAN
    Recommended name:
    PGAP2-interacting protein
    Protein Accession:
    Q9H720
    Secondary Accessions:
    • B2RPD7

    Protein attributes for CWH43 Gene

    Size:
    699 amino acids
    Molecular mass:
    78584 Da
    Quaternary structure:
    • Interacts with PGAP2/FRAG1.

neXtProt entry for CWH43 Gene

Proteomics data for CWH43 Gene at MOPED

Post-translational modifications for CWH43 Gene

  • Glycosylation at Asn 455
  • Modification sites at PhosphoSitePlus

Other Protein References for CWH43 Gene

No data available for DME Specific Peptides for CWH43 Gene

Domains & Families for CWH43 Gene

Protein Domains for CWH43 Gene

Suggested Antigen Peptide Sequences for CWH43 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H720

UniProtKB/Swiss-Prot:

PG2IP_HUMAN :
  • Belongs to the PGAP2IP family.
Family:
  • Belongs to the PGAP2IP family.
genes like me logo Genes that share domains with CWH43: view

No data available for Gene Families for CWH43 Gene

Function for CWH43 Gene

Molecular function for CWH43 Gene

UniProtKB/Swiss-Prot Function:
Involved in lipid remodeling during GPI-anchor maturation.
genes like me logo Genes that share phenotypes with CWH43: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CWH43 Gene

Localization for CWH43 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CWH43 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CWH43 Gene COMPARTMENTS Subcellular localization image for CWH43 gene
Compartment Confidence
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for CWH43 Gene

Pathways & Interactions for CWH43 Gene

SuperPathways for CWH43 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CWH43 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CWH43 Gene

Drugs & Compounds for CWH43 Gene

No Compound Related Data Available

Transcripts for CWH43 Gene

Unigene Clusters for CWH43 Gene

Cell wall biogenesis 43 C-terminal homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CWH43 Gene

No ASD Table

Relevant External Links for CWH43 Gene

GeneLoc Exon Structure for
CWH43
ECgene alternative splicing isoforms for
CWH43

Expression for CWH43 Gene

mRNA expression in normal human tissues for CWH43 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CWH43 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x10.1), Esophagus - Mucosa (x9.2), Skin - Not Sun Exposed (Suprapubic) (x9.1), and Colon - Transverse (x5.5).

Protein differential expression in normal tissues from HIPED for CWH43 Gene

This gene is overexpressed in Plasma (67.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CWH43 Gene



SOURCE GeneReport for Unigene cluster for CWH43 Gene Hs.479703

genes like me logo Genes that share expression patterns with CWH43: view

Protein tissue co-expression partners for CWH43 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CWH43 Gene

Orthologs for CWH43 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CWH43 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CWH43 35
  • 87.32 (n)
  • 85.41 (a)
CWH43 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CWH43 35
  • 87.5 (n)
  • 87.21 (a)
CWH43 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cwh43 35
  • 82.4 (n)
  • 82.98 (a)
Cwh43 16
Cwh43 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CWH43 35
  • 99.67 (n)
  • 99.43 (a)
CWH43 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cwh43 35
  • 82.16 (n)
  • 82.98 (a)
chicken
(Gallus gallus)
Aves CWH43 35
  • 70.73 (n)
  • 67.86 (a)
CWH43 36
  • 67 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL043W 35
  • 41.37 (n)
  • 30.99 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A11132g 35
  • 44.13 (n)
  • 33.02 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CWH43 35
  • 44.1 (n)
  • 32.92 (a)
CWH43 36
  • 22 (a)
OneToOne
CWH43 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9941 35
bread mold
(Neurospora crassa)
Ascomycetes NCU05895 35
  • 42.32 (n)
  • 33.68 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC589.12 35
  • 42.81 (n)
  • 30.53 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToOne
Species with no ortholog for CWH43:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CWH43 Gene

ENSEMBL:
Gene Tree for CWH43 (if available)
TreeFam:
Gene Tree for CWH43 (if available)

Paralogs for CWH43 Gene

No data available for Paralogs for CWH43 Gene

Variants for CWH43 Gene

Sequence variations from dbSNP and Humsavar for CWH43 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs3747690 - 48,986,433(+) CGATG(A/C)CCTCG upstream-variant-2KB, reference, missense
rs1051447 - 49,061,855(+) ACCAT(A/C)ATTTT reference, missense
rs936134 -- 49,000,204(-) CTTCT(A/T)TTACT intron-variant
rs936135 -- 48,989,523(-) ACATC(C/T)TAGTG intron-variant, upstream-variant-2KB
rs1350121 -- 48,999,790(-) GCTCC(A/C)CTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CWH43 Gene

Variant ID Type Subtype PubMed ID
nsv879010 CNV Loss 21882294
nsv441875 CNV CNV 18776908
dgv1618e1 CNV Complex 17122850
nsv428442 CNV Loss 18775914

Variation tolerance for CWH43 Gene

Residual Variation Intolerance Score: 5.79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.87; 97.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CWH43 Gene

HapMap Linkage Disequilibrium report
CWH43

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CWH43 Gene

Disorders for CWH43 Gene

Relevant External Links for CWH43

Genetic Association Database (GAD)
CWH43
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CWH43

No disorders were found for CWH43 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CWH43 Gene

Publications for CWH43 Gene

  1. Serum ferritin levels are associated with a distinct phenotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy. (PMID: 22095909) Lange C.M. … Bochud P.Y. (Hepatology 2012) 3 48 67
  2. CWH43 is required for the introduction of ceramides into GPI anchors in Saccharomyces cerevisiae. (PMID: 17714445) Ghugtyal V. … Conzelmann A. (Mol. Microbiol. 2007) 2 3
  3. Saccharomyces cerevisiae CWH43 is involved in the remodeling of the lipid moiety of GPI anchors to ceramides. (PMID: 17761529) Umemura M. … Jigami Y. (Mol. Biol. Cell 2007) 2 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CWH43 Gene

Sources for CWH43 Gene

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