CWF19L2 Gene
protein-coding GIFtS : 44
GCID: GC11 M107197
CWF19-like 2, cell cycle control (S. pombe)
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Aliasesfor CWF19L2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases CWF19-Like 2, Cell Cycle Control (S. Pombe) 1 2 FLJ323431 CWF19-Like Protein 22
Export aliases for CWF19L2 gene to outside databases Previous GC identifers: GC11M106735 GC11M106702 GC11M103133
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Summariesfor CWF19L2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor CWF19L2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_033899.8 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CWF19L2 gene promoter: Bach1 Pbx1a CUTL1 Cdc5 C/EBPalpha Gfi-1 AREB6 HSF2 Hlf Other transcription factors Search SABiosciences Chromatin IP Primers for CWF19L2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CWF19L2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11q22.3 Ensembl cytogenetic band: 11q22.3 HGNC cytogenetic band: 11q23.1 CWF19L2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11M107197: view genomic region
(about GC identifiers )
Start:
107,197,071 bp from pter
End:
107,328,572 bp from pter
Size:
131,502 bases
Orientation:
minus strand
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Proteinsfor CWF19L2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: C19L2_HUMAN, Q2TBE0 (See
protein sequence )Recommended Name: CWF19-like protein 2 Size : 894 amino acids; 103787 Da
Caution : It is uncertain whether Met-1 or Met-5 is the initiator
Sequence caution : Sequence=AAI10440.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAI10441.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI10441.1; Type=Frameshift; Positions=754; Sequence=AAI10442.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI10443.2; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI18670.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB71307.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions : A4FU66 A4FU67 A4FU68 Q6PHW1 Q96MI1Alternative splicing : 3 isoforms : Q2TBE0-1 Q2TBE0-2 Q2TBE0-3 (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)Explore the universe of human proteins at neXtProt for CWF19L2: NX_Q2TBE0 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q2TBE0 CWF19L2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_689647.2 ENSEMBL proteins: ENSP00000282251 ENSP00000411736 ENSP00000434704 ENSP00000387533 Human Recombinant Protein Products: CWF19L2 Antibody Products: Assay Products for CWF19L2:
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Protein
Domains / Familiesfor CWF19L2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
CWF19L2 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q2TBE0 ProtoNet protein and cluster: Q2TBE0
1 Blocks protein family : IPB006768 Protein similar to CwfJ UniProtKB/Swiss-Prot: C19L2_HUMAN, Q2TBE0 Similarity : Belongs to the CWF19 family
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Functionfor CWF19L2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CWF19L2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CWF19L2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CWF19L2 (NM_152434 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CWF19L2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CWF19L2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CWF19L2
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003824 catalytic activity
IEA --
CWF19L2 for ontologies About GeneDecksing 2 GenomeRNAi human phenotypes for CWF19L2 :
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Pathways & Interactionsfor CWF19L2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CWF19L2 1 Interacting protein for CWF19L2 (Q2TBE0 3 ) via UniProtKB, MINT, STRING, and/or I2D About this table
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Drugs & Compoundsfor CWF19L2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for CWF19L2 Search CenterWatch for drugs/clinical trials and news about CWF19L2 / C19L2
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Transcriptsfor CWF19L2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CWF19L2 gene: NM_152434.2 Unigene Cluster for CWF19L2:
CWF19-like 2, cell cycle control (S. pombe) Hs.212140 [show with all ESTs ] Unigene Representative Sequence: NM_152434 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000282251 (uc009yxo.3 uc010rvp.2 ) ENST00000431778 (uc001pjh.4 )ENST00000532251 ENST00000462890 ENST00000433523 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CWF19L2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CWF19L2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CWF19L2 (NM_152434 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CWF19L2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CWF19L2
Additional cDNA sequence: AK056905.1 AK126881.1 AK293001.1 AL713739.1 BC016611.1 BC028043.2 BC056241.1 BC070142.1 BC107418.1 BC110439.1 BC110440.1 BC110441.1 BC110442.1 BC118669.1 BX647832.1 BX648704.1 BX649022.1
3 DOTS entries : DT.101982120 DT.108856
DT.97807172 24/66 AceView cDNA sequences (see all 66 ):
AI805029 AL713739 BQ876356 BX648704 BC070142 BF222365 AI783699 BE645862 AI284320 AK126881 AW515353 AL712586 BC028043 BG055074 AI026082 AI088098 BU601362 BF437163 BU951988 BU633869 CD689043 AI559919 BU951930 NM_152434 GeneLoc Exon Structure
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Expression for CWF19L2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CWF19L2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GTTGTTAAGT
About this image See CWF19L2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CWF19L2 SOURCE GeneReport for Unigene cluster: Hs.212140 SABiosciences Custom PCR Arrays for CWF19L2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CWF19L2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat CWF19L2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CWF19L2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CWF19L2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CWF19L2
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Orthologsfor CWF19L2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for CWF19L2 gene from 8/29 species (see all 29 ) About this table
ENSEMBL Gene Tree for CWF19L2 (if available)TreeFam Gene Tree for CWF19L2 (if available)
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Paralogsfor CWF19L2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for CWF19L2 gene CWF19L1 2
CWF19L2 for paralogs About GeneDecksing
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Genomic Variantsfor CWF19L2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 11 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for CWF19L2 (107197071 - 107328572 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 15 variations for CWF19L2 15 CNVs : 86016 66062 2957 31848 86015 0423 34910 37488 66061 75809 101337 75810 6901 75808 34911
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CWF19L2
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Disorders
/ Diseasesfor CWF19L2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
CWF19L2 for disorders About GeneDecksing 2 diseases for CWF19L2 : About MalaCards breast cancer malaria Human Genome Epidemiology (HuGE) Navigator: CWF19L2 (3 documents) Export disorders for CWF19L2 gene to outside databases
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Publicationsfor CWF19L2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CWF19L2 gene, integrated from 9 sources (see all 14 ): (articles sorted by number of sources associating them with CWF19L2) Utopia : connect your pdf to the dynamic world of online information
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 , 3 Ota T.... Sugano S. (2004) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692) 2 Rigbolt K.T....Blagoev B. (2011) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014) 1 Shimada M....Tokunaga K. (2010) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332) 2 Mayya V.... Han D.K. (2009) Genome-wide analysis identifies 16q deletion associated with survival, molecular subtypes, mRNA expression, and germline haplotypes in breast cancer patients. (PubMed id 18398821) 1 Nordgard S.H....Kristensen V.N. (2008) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 2 Dephoure N.... Gygi S.P. (2008) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 2 Olsen J.V....Mann M. (2006)
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External Searches for CWF19L2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CWF19L2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CWF19L2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing CWF19L2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for CWF19L2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for CWF19L2 gene: Search GeneIP for patents involving CWF19L2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CWF19L2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for CWF19L2 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for CWF19L2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CWF19L2 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CWF19L2 OriGene 3'-UTR Clone for CWF19L2 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CWF19L2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CWF19L2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CWF19L2 OriGene Custom Protein Services for CWF19L2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CWF19L2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CWF19L2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CWF19L2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat CWF19L2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CWF19L2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CWF19L2
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CWF19L2
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