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Aliases for CWF19L2 Gene

Aliases for CWF19L2 Gene

  • CWF19-Like 2, Cell Cycle Control (S. Pombe) 2 3 5

External Ids for CWF19L2 Gene

Previous GeneCards Identifiers for CWF19L2 Gene

  • GC11M106735
  • GC11M106702
  • GC11M107197
  • GC11M103133

Summaries for CWF19L2 Gene

GeneCards Summary for CWF19L2 Gene

CWF19L2 (CWF19-Like 2, Cell Cycle Control (S. Pombe)) is a Protein Coding gene. An important paralog of this gene is CWF19L1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CWF19L2 Gene

Genomics for CWF19L2 Gene

Regulatory Elements for CWF19L2 Gene

Enhancers for CWF19L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F107385 0.8 ENCODE 19.9 +71.9 71885 1.5 SOX13 SAP130 CEBPG TEAD3 ZNF316 MAFK MIXL1 SOX5 TEAD1 HLF CWF19L2 LOC105369477 ASS1P13 SMARCE1P1
GH11F107456 1 ENCODE 8.3 +0.1 111 1.5 MLX ARID4B SIN3A DMAP1 ETS1 YY1 SLC30A9 ELK1 CBX5 ZNF207 LOC105369477 CWF19L2 ASS1P13 SMARCE1P1
GH11F107396 0.6 ENCODE 10.8 +60.4 60432 1.2 ZFHX2 SCRT2 NFE2 MAFK EGR2 LOC105369477 ASS1P13 CWF19L2 SMARCE1P1
GH11F107544 0.9 Ensembl ENCODE 0.2 -87.3 -87289 2.2 SCRT1 PKNOX1 MTA2 JUN EP300 IKZF1 SCRT2 FOS ALKBH8 ELMOD1 LOC105369477 CWF19L2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CWF19L2 on UCSC Golden Path with GeneCards custom track

Promoters for CWF19L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001771860 446 2400 MLX ARID4B SIN3A DMAP1 ETS1 YY1 SLC30A9 ELK1 CBX5 ZNF207

Genomic Location for CWF19L2 Gene

107,326,345 bp from pter
107,457,846 bp from pter
131,502 bases
Minus strand

Genomic View for CWF19L2 Gene

Genes around CWF19L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CWF19L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CWF19L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CWF19L2 Gene

Proteins for CWF19L2 Gene

  • Protein details for CWF19L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CWF19-like protein 2
    Protein Accession:
    Secondary Accessions:
    • A4FU66
    • A4FU67
    • A4FU68
    • Q6PHW1
    • Q96MI1

    Protein attributes for CWF19L2 Gene

    894 amino acids
    Molecular mass:
    103787 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI10440.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI10441.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI10441.1; Type=Frameshift; Positions=754; Evidence={ECO:0000305}; Sequence=AAI10442.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI10443.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI18670.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB71307.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CWF19L2 Gene


neXtProt entry for CWF19L2 Gene

Post-translational modifications for CWF19L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CWF19L2 Gene

No data available for DME Specific Peptides for CWF19L2 Gene

Domains & Families for CWF19L2 Gene

Protein Domains for CWF19L2 Gene

Suggested Antigen Peptide Sequences for CWF19L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CWF19 family.
  • Belongs to the CWF19 family.
genes like me logo Genes that share domains with CWF19L2: view

No data available for Gene Families for CWF19L2 Gene

Function for CWF19L2 Gene

Gene Ontology (GO) - Molecular Function for CWF19L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
genes like me logo Genes that share ontologies with CWF19L2: view
genes like me logo Genes that share phenotypes with CWF19L2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CWF19L2 Gene

Localization for CWF19L2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CWF19L2 gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CWF19L2 Gene

Pathways & Interactions for CWF19L2 Gene

SuperPathways for CWF19L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CWF19L2 Gene


No data available for Pathways by source and SIGNOR curated interactions for CWF19L2 Gene

Transcripts for CWF19L2 Gene

Unigene Clusters for CWF19L2 Gene

CWF19-like 2, cell cycle control (S. pombe):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CWF19L2 Gene

No ASD Table

Relevant External Links for CWF19L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CWF19L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CWF19L2 Gene

Protein differential expression in normal tissues from HIPED for CWF19L2 Gene

This gene is overexpressed in Platelet (17.8), Heart (12.5), Peripheral blood mononuclear cells (10.1), and Blymphocyte (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CWF19L2 Gene

Protein tissue co-expression partners for CWF19L2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CWF19L2 Gene:


SOURCE GeneReport for Unigene cluster for CWF19L2 Gene:

genes like me logo Genes that share expression patterns with CWF19L2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CWF19L2 Gene

Orthologs for CWF19L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CWF19L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CWF19L2 34 35
  • 99.48 (n)
(Canis familiaris)
Mammalia CWF19L2 34 35
  • 88.48 (n)
(Bos Taurus)
Mammalia CWF19L2 34 35
  • 88.06 (n)
(Mus musculus)
Mammalia Cwf19l2 34 16 35
  • 81.82 (n)
(Rattus norvegicus)
Mammalia Cwf19l2 34
  • 81.3 (n)
(Monodelphis domestica)
Mammalia CWF19L2 35
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia CWF19L2 35
  • 62 (a)
(Gallus gallus)
Aves CWF19L2 34 35
  • 67.43 (n)
(Anolis carolinensis)
Reptilia CWF19L2 35
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cwf19l2 34
  • 63.75 (n)
Str.659 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.5514 34
(Danio rerio)
Actinopterygii LOC100534870 34
  • 61.18 (n)
cwf19l2 35
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9213 34 35
  • 46.12 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010932 34
  • 46.1 (n)
(Caenorhabditis elegans)
Secernentea B0361.2 34 35
  • 50.8 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4472 35
  • 38 (a)
Species where no ortholog for CWF19L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CWF19L2 Gene

Gene Tree for CWF19L2 (if available)
Gene Tree for CWF19L2 (if available)

Paralogs for CWF19L2 Gene

Paralogs for CWF19L2 Gene

genes like me logo Genes that share paralogs with CWF19L2: view

Variants for CWF19L2 Gene

Sequence variations from dbSNP and Humsavar for CWF19L2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10103258 -- 107,363,550(-) aaatt(A/C/T)tgggt intron-variant
rs10160608 -- 107,415,701(+) GCACA(C/T)TGATA intron-variant
rs10160611 -- 107,415,909(+) cctgg(A/C)caaca intron-variant
rs1016351 -- 107,446,791(+) ATACT(A/C)ATTTT intron-variant
rs10458952 -- 107,422,172(+) ttgac(C/T)cttga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CWF19L2 Gene

Variant ID Type Subtype PubMed ID
nsv972069 CNV duplication 23825009
nsv971960 OTHER complex 23825009
nsv8872 CNV loss 18304495
nsv832261 CNV loss 17160897
nsv75 CNV deletion 15895083
nsv556376 CNV gain 21841781
nsv556375 CNV loss 21841781
nsv556372 CNV loss 21841781
nsv556337 CNV loss 21841781
nsv556329 CNV loss 21841781
nsv556298 CNV gain+loss 21841781
nsv556297 CNV gain 21841781
nsv556283 CNV loss 21841781
nsv556282 CNV loss 21841781
nsv556281 CNV loss 21841781
nsv556280 CNV gain 21841781
nsv514590 CNV gain+loss 21397061
nsv511483 CNV gain 21212237
nsv509441 CNV insertion 20534489
nsv508655 CNV deletion 20534489
nsv475 CNV deletion 18451855
nsv474223 CNV novel sequence insertion 20440878
nsv473163 CNV novel sequence insertion 20440878
nsv433518 CNV loss 18776910
nsv1121843 CNV deletion 24896259
nsv1070485 CNV deletion 25765185
nsv1035911 CNV gain 25217958
nsv1035610 CNV loss 25217958
esv3627647 CNV loss 21293372
esv3627644 CNV gain 21293372
esv3627642 CNV gain 21293372
esv3580083 CNV gain 25503493
esv3579900 CNV loss 25503493
esv33566 CNV gain+loss 17666407
esv2760477 CNV gain+loss 21179565
esv2760173 CNV gain+loss 21179565
esv2759864 CNV loss 17122850
esv2745047 CNV deletion 23290073
esv2665722 CNV deletion 23128226
esv26501 CNV gain+loss 19812545
esv2519079 CNV loss 19546169
esv2421980 CNV deletion 20811451
esv1000794 CNV deletion 20482838
dgv240n67 CNV loss 20364138
dgv239e199 CNV deletion 23128226
dgv2173n54 CNV loss 21841781
dgv2172n54 CNV loss 21841781
dgv2171n54 CNV loss 21841781
dgv2170n54 CNV loss 21841781
dgv2169n54 CNV loss 21841781
dgv2168n54 CNV loss 21841781
dgv2167n54 CNV loss 21841781
dgv2166n54 CNV gain+loss 21841781
dgv2165n54 CNV loss 21841781
dgv2164n54 CNV loss 21841781
dgv2163n54 CNV loss 21841781
dgv2162n54 CNV loss 21841781
dgv2161n54 CNV loss 21841781

Variation tolerance for CWF19L2 Gene

Residual Variation Intolerance Score: 41.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.46; 92.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CWF19L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CWF19L2 Gene

Disorders for CWF19L2 Gene

Relevant External Links for CWF19L2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CWF19L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CWF19L2 Gene

Publications for CWF19L2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 46 64
  4. Genome-wide analysis identifies 16q deletion associated with survival, molecular subtypes, mRNA expression, and germline haplotypes in breast cancer patients. (PMID: 18398821) Nordgard S.H. … Kristensen V.N. (Genes Chromosomes Cancer 2008) 3 46 64
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64

Products for CWF19L2 Gene

Sources for CWF19L2 Gene

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