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Aliases for CWF19L2 Gene

Aliases for CWF19L2 Gene

  • CWF19-Like 2, Cell Cycle Control (S. Pombe) 2 3 5

External Ids for CWF19L2 Gene

Previous GeneCards Identifiers for CWF19L2 Gene

  • GC11M106735
  • GC11M106702
  • GC11M107197
  • GC11M103133

Summaries for CWF19L2 Gene

GeneCards Summary for CWF19L2 Gene

CWF19L2 (CWF19-Like 2, Cell Cycle Control (S. Pombe)) is a Protein Coding gene. An important paralog of this gene is CWF19L1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CWF19L2 Gene

Genomics for CWF19L2 Gene

Regulatory Elements for CWF19L2 Gene

Promoters for CWF19L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CWF19L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CWF19L2 Gene

107,326,345 bp from pter
107,457,846 bp from pter
131,502 bases
Minus strand

Genomic View for CWF19L2 Gene

Genes around CWF19L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CWF19L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CWF19L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CWF19L2 Gene

Proteins for CWF19L2 Gene

  • Protein details for CWF19L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CWF19-like protein 2
    Protein Accession:
    Secondary Accessions:
    • A4FU66
    • A4FU67
    • A4FU68
    • Q6PHW1
    • Q96MI1

    Protein attributes for CWF19L2 Gene

    894 amino acids
    Molecular mass:
    103787 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI10440.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI10441.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI10441.1; Type=Frameshift; Positions=754; Evidence={ECO:0000305}; Sequence=AAI10442.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI10443.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI18670.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB71307.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CWF19L2 Gene


neXtProt entry for CWF19L2 Gene

Proteomics data for CWF19L2 Gene at MOPED

Post-translational modifications for CWF19L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CWF19L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CWF19L2 Gene

Domains & Families for CWF19L2 Gene

Protein Domains for CWF19L2 Gene

Suggested Antigen Peptide Sequences for CWF19L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CWF19 family.
  • Belongs to the CWF19 family.
genes like me logo Genes that share domains with CWF19L2: view

No data available for Gene Families for CWF19L2 Gene

Function for CWF19L2 Gene

genes like me logo Genes that share phenotypes with CWF19L2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CWF19L2 Gene

Localization for CWF19L2 Gene

Subcellular locations from

Jensen Localization Image for CWF19L2 Gene COMPARTMENTS Subcellular localization image for CWF19L2 gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CWF19L2 Gene

Pathways & Interactions for CWF19L2 Gene

SuperPathways for CWF19L2 Gene

No Data Available

Interacting Proteins for CWF19L2 Gene

Gene Ontology (GO) - Biological Process for CWF19L2 Gene


No data available for Pathways by source and SIGNOR curated interactions for CWF19L2 Gene

Drugs & Compounds for CWF19L2 Gene

No Compound Related Data Available

Transcripts for CWF19L2 Gene

Unigene Clusters for CWF19L2 Gene

CWF19-like 2, cell cycle control (S. pombe):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CWF19L2 Gene

No ASD Table

Relevant External Links for CWF19L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CWF19L2 Gene

mRNA expression in normal human tissues for CWF19L2 Gene

Protein differential expression in normal tissues from HIPED for CWF19L2 Gene

This gene is overexpressed in Platelet (17.8), Heart (12.5), Peripheral blood mononuclear cells (10.1), and Blymphocyte (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CWF19L2 Gene

SOURCE GeneReport for Unigene cluster for CWF19L2 Gene Hs.212140

genes like me logo Genes that share expression patterns with CWF19L2: view

Protein tissue co-expression partners for CWF19L2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CWF19L2 Gene

Orthologs for CWF19L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CWF19L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CWF19L2 35
  • 88.06 (n)
  • 83.56 (a)
CWF19L2 36
  • 81 (a)
(Canis familiaris)
Mammalia CWF19L2 35
  • 88.48 (n)
  • 85.91 (a)
CWF19L2 36
  • 84 (a)
(Mus musculus)
Mammalia Cwf19l2 35
  • 81.82 (n)
  • 74.83 (a)
Cwf19l2 16
Cwf19l2 36
  • 73 (a)
(Pan troglodytes)
Mammalia CWF19L2 35
  • 99.48 (n)
  • 99.1 (a)
CWF19L2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cwf19l2 35
  • 81.3 (n)
  • 75.11 (a)
(Monodelphis domestica)
Mammalia CWF19L2 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia CWF19L2 36
  • 62 (a)
(Gallus gallus)
Aves CWF19L2 35
  • 67.43 (n)
  • 61.4 (a)
CWF19L2 36
  • 56 (a)
(Anolis carolinensis)
Reptilia CWF19L2 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cwf19l2 35
  • 63.75 (n)
  • 60.02 (a)
Str.659 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.5514 35
(Danio rerio)
Actinopterygii LOC100534870 35
  • 61.18 (n)
  • 60.32 (a)
cwf19l2 36
  • 46 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010932 35
  • 46.1 (n)
  • 35.86 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9213 35
  • 46.12 (n)
  • 37.44 (a)
CG9213 36
  • 32 (a)
(Caenorhabditis elegans)
Secernentea B0361.2 35
  • 50.8 (n)
  • 39.84 (a)
B0361.2 36
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4472 36
  • 38 (a)
Species with no ortholog for CWF19L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CWF19L2 Gene

Gene Tree for CWF19L2 (if available)
Gene Tree for CWF19L2 (if available)

Paralogs for CWF19L2 Gene

Paralogs for CWF19L2 Gene

genes like me logo Genes that share paralogs with CWF19L2: view

Variants for CWF19L2 Gene

Sequence variations from dbSNP and Humsavar for CWF19L2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs608634 - 107,439,126(+) AGGTG(G/T)AAGAC nc-transcript-variant, reference, missense
rs659040 - 107,428,905(+) TTGGT(A/G)TTCAT intron-variant, nc-transcript-variant, reference, missense
rs35968518 - 107,428,897(+) GGAAC(A/C)TGTTG intron-variant, nc-transcript-variant, reference, missense
rs17106909 - 107,416,217(+) TACCC(C/T)AGATT nc-transcript-variant, reference, missense
rs3758911 - 107,326,914(-) AAACT(A/G/T)TTGAG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CWF19L2 Gene

Variant ID Type Subtype PubMed ID
nsv898364 CNV Gain 21882294
dgv1312n71 CNV Gain 21882294
nsv898373 CNV Gain 21882294
nsv832261 CNV Loss 17160897
nsv898374 CNV Loss 21882294
nsv475 CNV Loss 18451855
esv2745047 CNV Deletion 23290073
nsv75 CNV Loss 15895083
nsv508655 CNV Loss 20534489
nsv509441 CNV Insertion 20534489
nsv8872 CNV Loss 18304495
esv1000794 CNV Deletion 20482838
esv26501 CNV Gain+Loss 19812545
dgv239e199 CNV Deletion 23128226
esv2665722 CNV Deletion 23128226
esv2421980 CNV Deletion 20811451
dgv240n67 CNV Loss 20364138
nsv433518 CNV Loss 18776910
nsv511483 CNV Gain 21212237
nsv514590 CNV Complex 21397061
esv2519079 CNV Loss 19546169
esv33566 CNV Gain+Loss 17666407
nsv898375 CNV Gain 21882294
nsv898376 CNV Gain 21882294
nsv898377 CNV Loss 21882294
dgv438e1 CNV Complex 17122850

Variation tolerance for CWF19L2 Gene

Residual Variation Intolerance Score: 41.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.46; 92.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CWF19L2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CWF19L2 Gene

Disorders for CWF19L2 Gene

Relevant External Links for CWF19L2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CWF19L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CWF19L2 Gene

Publications for CWF19L2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. (PMID: 25184681) Hill S.J. … Livingston D.M. (Genes Dev. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for CWF19L2 Gene

Sources for CWF19L2 Gene

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