CWF19L1 Gene
protein-coding GIFtS: 46
GCID: GC10M101982
|
|
CWF19-like 1, cell cycle control (S. pombe)
| |
Aliases
for CWF19L1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CWF19-Like 1, Cell Cycle Control (S. Pombe)1 2 | | FLJ109981 | | CWF19-Like Protein 12 |
Export aliases for CWF19L1 gene to outside databasesPrevious GC identifers: GC10M101657 GC10M095621 |
Summaries
for CWF19L1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CWF19L1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CWF19L1 gene promoter:
Elk-1 ATF-2 CUTL1 FOXL1 YY1 MEF-2A FOXO4 FOXJ2 (long isoform) aMEF-2 FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CWF19L1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CWF19L1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q24.31 Ensembl cytogenetic band: 10q24.31 HGNC cytogenetic band: 10q24.31CWF19L1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M101982: view genomic region
(about GC identifiers)
Start:
|
101,992,050 bp from pter |
End:
|
102,027,437 bp from pter |
Size:
|
35,388 bases |
Orientation:
|
minus strand |
|
Proteins
for CWF19L1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: C19L1_HUMAN, Q69YN2 (See
protein sequence)Recommended Name: CWF19-like protein 1 Size: 538 amino acids; 60619 Da
Sequence caution: Sequence=CAH72402.1; Type=Erroneous gene model prediction;
Secondary accessions: B4DHX1 D3DR66 Q5W0I3 Q96HC3 Q9H865 Q9NV13Alternative splicing: 3 isoforms: Q69YN2-1 Q69YN2-2 Q69YN2-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CWF19L1: NX_Q69YN2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q69YN2
CWF19L1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060764.3
ENSEMBL proteins: ENSP00000433798 ENSP00000359405 ENSP00000326411
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
CWF19L1 for ontologies About GeneDecksing
CWF19L1 Antibody Products:
Assay Products for CWF19L1: |
Protein
Domains /
Families
for CWF19L1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CWF19L1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q69YN2ProtoNet protein and cluster: Q69YN2 1 Blocks protein family: IPB006768 Protein similar to CwfJ
UniProtKB/Swiss-Prot: C19L1_HUMAN, Q69YN2Similarity: Belongs to the CWF19 family |
Function
for CWF19L1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CWF19L1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CWF19L1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CWF19L1 (NM_018294) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CWF19L1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CWF19L1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CWF19L1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0003824 | catalytic activity |
IEA | -- |
CWF19L1 for ontologies About GeneDecksing
|
Pathways & Interactions
for CWF19L1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CWF19L1
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/9 Interacting proteins for CWF19L1 (Q69YN22, 3 ENSP000003264114) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
CWF19L1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CWF19L1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CWF19L1
Search CenterWatch for drugs/clinical trials and news about CWF19L1 / C19L1
|
Transcripts
for CWF19L1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CWF19L1 gene: NM_018294.4 Unigene Cluster for CWF19L1: CWF19-like 1, cell cycle control (S. pombe) Hs.215502 [show with all ESTs]Unigene Representative Sequence: AK05531311 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000485266 ENST00000472872 ENST00000468709(uc001kqs.1) ENST00000482452
ENST00000478047 ENST00000370379 ENST00000466955 ENST00000466408 ENST00000496796
ENST00000473842 ENST00000354105(uc001kqq.1 uc001kqr.1 uc001kqt.1 uc010qpn.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CWF19L1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CWF19L1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CWF19L1 (NM_018294) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CWF19L1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CWF19L1 |
Additional cDNA sequence: AK000876.1 AK055313.1 AK097895.1 AK225590.1 AK295303.1 AL832515.1 17 DOTS entries: DT.100777952 DT.443013 DT.100811600 DT.121269183 DT.95275283 DT.100777950 DT.99986173 DT.440113 DT.99967903 DT.121269119 DT.91844284 DT.121269129 DT.121269145 DT.121269155 DT.92431837 DT.99932366 DT.121269126 24/149 AceView cDNA sequences (see all 149): AI340302 BX471305 BM818086 BQ932343 BM827722 BI518796 BF061077 BG503643 AA252743 BG288853 AU280189 AI370672 CK430555 AK001860 BM550871 AA400626 AI888946 CD672837 AW401703 BM810541 AI671280 AU116969 BM918784 BP344980
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for CWF19L1 (see all 11) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | · | 2g | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | | | - | | - | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | - | | | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | |
| ExUns: | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 |
|---|
|
| SP1: | | | | | | | | | | | |
| SP2: | | | | | | | | | | | |
| SP3: | | | | | | | | | | | |
| SP4: | | | | | | | | | | | |
| SP5: | | | | | | | | | | |
ECgene alternative splicing isoforms for CWF19L1
|
Expression
for CWF19L1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CWF19L1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CWF19L1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CWF19L1
SOURCE GeneReport for Unigene cluster: Hs.215502
SABiosciences Custom PCR Arrays for CWF19L1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CWF19L1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CWF19L1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CWF19L1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CWF19L1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CWF19L1 |
Orthologs
for CWF19L1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CWF19L1 gene from 10/30 species (see all 30) About this table
ENSEMBL Gene Tree for CWF19L1 (if available)
TreeFam Gene Tree for CWF19L1 (if available) |
Paralogs
for CWF19L1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CWF19L1 gene
- CWF19L22
CWF19L1 for paralogs About GeneDecksing
|
Genomic Variants
for CWF19L1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CWF19L1 (101992050 - 102027437 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CWF19L1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CWF19L1 |
|
Disorders
/ Diseases
for CWF19L1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CWF19L1 for disorders About GeneDecksing
2  diseases for CWF19L1: About MalaCardsalzheimer's disease malaria
Human Genome Epidemiology (HuGE) Navigator: CWF19L1 (2 documents)
Export disorders for CWF19L1 gene to outside databases
|
Publications
for CWF19L1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CWF19L1 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with CWF19L1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1 Hosgood H.D....Lan Q. (2009)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for CWF19L1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CWF19L1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CWF19L1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CWF19L1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CWF19L1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CWF19L1 gene:
Search GeneIP for patents involving CWF19L1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CWF19L1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CWF19L1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CWF19L1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CWF19L1 | | | OriGene Protein Over-expression Lysate for CWF19L1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CWF19L1 | | OriGene 3'-UTR Clone for CWF19L1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CWF19L1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CWF19L1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CWF19L1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| |  |  |  |  | | | | |
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 | | | CWF19L1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CWF19L1 |
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