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Aliases for CWC27 Gene

Aliases for CWC27 Gene

  • CWC27 Spliceosome-Associated Protein Homolog (S. Cerevisiae) 2 3
  • Serologically Defined Colon Cancer Antigen 10 2 3 4
  • Antigen NY-CO-10 3 4
  • PPIase CWC27 3 4
  • SDCCAG10 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase CWC27 Homolog 3
  • Peptidyl-Prolyl Cis-Trans Isomerase SDCCAG10 3
  • PPIase SDCCAG10 3
  • EC 5.2.1.8 4
  • NY-CO-10 3

External Ids for CWC27 Gene

Previous HGNC Symbols for CWC27 Gene

  • SDCCAG10

Previous GeneCards Identifiers for CWC27 Gene

  • GC05P064064
  • GC05P061019

Summaries for CWC27 Gene

GeneCards Summary for CWC27 Gene

CWC27 (CWC27 Spliceosome-Associated Protein Homolog (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIB.

UniProtKB/Swiss-Prot for CWC27 Gene

  • PPIases accelerate the folding of proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CWC27 Gene

Genomics for CWC27 Gene

Genomic Location for CWC27 Gene

Start:
64,768,928 bp from pter
End:
65,018,763 bp from pter
Size:
249,836 bases
Orientation:
Plus strand

Genomic View for CWC27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CWC27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CWC27 Gene

No data available for Regulatory Elements for CWC27 Gene

Proteins for CWC27 Gene

  • Protein details for CWC27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UX04-CWC27_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase CWC27 homolog
    Protein Accession:
    Q6UX04
    Secondary Accessions:
    • O60529
    • O60530
    • Q96EM3

    Protein attributes for CWC27 Gene

    Size:
    472 amino acids
    Molecular mass:
    53847 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC18041.1; Type=Frameshift; Positions=41; Evidence={ECO:0000305}; Sequence=AAC18042.1; Type=Frameshift; Positions=136; Evidence={ECO:0000305}; Sequence=AAH12117.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CWC27 Gene

    Alternative splice isoforms for CWC27 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CWC27 Gene

Proteomics data for CWC27 Gene at MOPED

Post-translational modifications for CWC27 Gene

  • Glycosylation at Asn109 and Asn201
  • Modification sites at PhosphoSitePlus

Other Protein References for CWC27 Gene

No data available for DME Specific Peptides for CWC27 Gene

Domains for CWC27 Gene

Suggested Antigen Peptide Sequences for CWC27 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UX04

UniProtKB/Swiss-Prot:

CWC27_HUMAN :
  • Q6UX04
Domain:
  • Contains 1 PPIase cyclophilin-type domain.
Family:
  • Belongs to the cyclophilin-type PPIase family.
genes like me logo Genes that share domains with CWC27: view

No data available for Gene Families for CWC27 Gene

Function for CWC27 Gene

Molecular function for CWC27 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Peptidylproline (omega=180) = peptidylproline (omega=0)
UniProtKB/Swiss-Prot Function: PPIases accelerate the folding of proteins.

Enzyme Numbers (IUBMB) for CWC27 Gene

Gene Ontology (GO) - Molecular Function for CWC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
genes like me logo Genes that share ontologies with CWC27: view

Phenotypes for CWC27 Gene

GenomeRNAi human phenotypes for CWC27:
genes like me logo Genes that share phenotypes with CWC27: view

Animal Model Products

CRISPR Products

miRNA for CWC27 Gene

miRTarBase miRNAs that target CWC27

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CWC27 Gene

Localization for CWC27 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CWC27 Gene COMPARTMENTS Subcellular localization image for CWC27 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for CWC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with CWC27: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CWC27 Gene

Pathways for CWC27 Gene

SuperPathways for CWC27 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CWC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0000413 protein peptidyl-prolyl isomerization IBA --
GO:0006457 protein folding IEA --
genes like me logo Genes that share ontologies with CWC27: view

No data available for Pathways by source for CWC27 Gene

Transcripts for CWC27 Gene

Unigene Clusters for CWC27 Gene

CWC27 spliceosome-associated protein homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CWC27

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CWC27 Gene

No ASD Table

Relevant External Links for CWC27 Gene

GeneLoc Exon Structure for
CWC27
ECgene alternative splicing isoforms for
CWC27

Expression for CWC27 Gene

mRNA expression in normal human tissues for CWC27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CWC27 Gene

SOURCE GeneReport for Unigene cluster for CWC27 Gene Hs.371372

genes like me logo Genes that share expressions with CWC27: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CWC27 Gene

Orthologs for CWC27 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CWC27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CWC27 35
  • 99.65 (n)
  • 99.36 (a)
CWC27 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CWC27 35
  • 93.15 (n)
  • 93.86 (a)
CWC27 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CWC27 35
  • 92.57 (n)
  • 93.42 (a)
CWC27 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cwc27 35
  • 86.47 (n)
  • 91.45 (a)
Cwc27 16
Cwc27 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CWC27 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cwc27 35
  • 86.08 (n)
  • 90.36 (a)
chicken
(Gallus gallus)
Aves CWC27 35
  • 77.3 (n)
  • 78.94 (a)
CWC27 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CWC27 36
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13268 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cwc27 35
  • 71.62 (n)
  • 73.25 (a)
Str.8713 35
zebrafish
(Danio rerio)
Actinopterygii cwc27 35
  • 67.24 (n)
  • 71.46 (a)
cwc27 36
  • 71 (a)
OneToOne
zgc56702 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007704 35
  • 53.94 (n)
  • 53.15 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10907 35
  • 53.08 (n)
  • 51.22 (a)
CG10907 36
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cyn-16 35
  • 53.72 (n)
  • 47.86 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CWC27 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G33060 35
  • 54.31 (n)
  • 48.02 (a)
rice
(Oryza sativa)
Liliopsida Os01g0582400 35
  • 52.26 (n)
  • 48.6 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.22856 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4732 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2858 36
  • 53 (a)
OneToOne
Species with no ortholog for CWC27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CWC27 Gene

ENSEMBL:
Gene Tree for CWC27 (if available)
TreeFam:
Gene Tree for CWC27 (if available)

Paralogs for CWC27 Gene

Paralogs for CWC27 Gene

Selected SIMAP similar genes for CWC27 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CWC27: view

Variants for CWC27 Gene

Sequence variations from dbSNP and Humsavar for CWC27 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs166475 -- 65,018,060(-) GCATA(C/T)AGAAC intron-variant
rs266556 -- 64,985,154(-) tggta(A/T)tggtg intron-variant
rs266557 -- 64,985,418(-) aatgg(A/G)gagac intron-variant
rs266558 -- 64,986,552(-) aactt(A/G)ctcta intron-variant
rs266559 -- 64,986,665(+) acctg(A/G)tgctt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CWC27 Gene

Variant ID Type Subtype PubMed ID
dgv6083n71 CNV Gain 21882294
nsv881755 CNV Gain 21882294
esv2632537 CNV Deletion 19546169
esv2678602 CNV Deletion 23128226
nsv881756 CNV Loss 21882294
esv2567621 CNV Deletion 19546169
esv2176429 CNV Deletion 18987734
esv5695 CNV Loss 19470904
esv1006564 CNV Deletion 20482838
esv2441864 CNV Deletion 19546169
esv2730274 CNV Deletion 23290073
nsv330028 CNV Loss 16902084

Relevant External Links for CWC27 Gene

HapMap Linkage Disequilibrium report
CWC27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CWC27 Gene

Disorders for CWC27 Gene

Relevant External Links for CWC27

Genetic Association Database (GAD)
CWC27
Human Genome Epidemiology (HuGE) Navigator
CWC27
genes like me logo Genes that share disorders with CWC27: view

No data available for UniProtKB/Swiss-Prot for CWC27 Gene

Publications for CWC27 Gene

  1. Characterization of human colon cancer antigens recognized by autologous antibodies. (PMID: 9610721) Scanlan M.J. … Old L.J. (Int. J. Cancer 1998) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome. (PMID: 19941820) Fabrizio P. … LA1hrmann R. (Mol. Cell 2009) 2 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for CWC27 Gene

Sources for CWC27 Gene

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