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Aliases for CWC27 Gene

Aliases for CWC27 Gene

  • CWC27 Spliceosome Associated Protein Homolog 2 3
  • Serologically Defined Colon Cancer Antigen 10 2 3 4
  • CWC27 Spliceosome-Associated Protein Homolog 2 3 5
  • Antigen NY-CO-10 3 4
  • PPIase CWC27 3 4
  • SDCCAG10 3 4
  • CWC27 Spliceosome-Associated Protein Homolog (S. Cerevisiae) 2
  • Peptidyl-Prolyl Cis-Trans Isomerase SDCCAG10 3
  • PPIase SDCCAG10 3
  • EC 4
  • SDCCAG-10 3
  • NY-CO-10 3

External Ids for CWC27 Gene

Previous HGNC Symbols for CWC27 Gene

  • SDCCAG10

Previous GeneCards Identifiers for CWC27 Gene

  • GC05P064064
  • GC05P061019

Summaries for CWC27 Gene

GeneCards Summary for CWC27 Gene

CWC27 (CWC27 Spliceosome Associated Protein Homolog) is a Protein Coding gene. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIB.

UniProtKB/Swiss-Prot for CWC27 Gene

  • PPIases accelerate the folding of proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CWC27 Gene

Genomics for CWC27 Gene

Regulatory Elements for CWC27 Gene

Enhancers for CWC27 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CWC27 on UCSC Golden Path with GeneCards custom track

Promoters for CWC27 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CWC27 on UCSC Golden Path with GeneCards custom track

Genomic Location for CWC27 Gene

64,768,918 bp from pter
65,018,763 bp from pter
249,846 bases
Plus strand

Genomic View for CWC27 Gene

Genes around CWC27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CWC27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CWC27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CWC27 Gene

Proteins for CWC27 Gene

  • Protein details for CWC27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase CWC27 homolog
    Protein Accession:
    Secondary Accessions:
    • O60529
    • O60530
    • Q96EM3

    Protein attributes for CWC27 Gene

    472 amino acids
    Molecular mass:
    53847 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC18041.1; Type=Frameshift; Positions=41; Evidence={ECO:0000305}; Sequence=AAC18042.1; Type=Frameshift; Positions=136; Evidence={ECO:0000305}; Sequence=AAH12117.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CWC27 Gene

    Alternative splice isoforms for CWC27 Gene


neXtProt entry for CWC27 Gene

Proteomics data for CWC27 Gene at MOPED

Post-translational modifications for CWC27 Gene

  • Glycosylation at Asn 109 and Asn 201
  • Modification sites at PhosphoSitePlus

Other Protein References for CWC27 Gene

No data available for DME Specific Peptides for CWC27 Gene

Domains & Families for CWC27 Gene

Gene Families for CWC27 Gene

Suggested Antigen Peptide Sequences for CWC27 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family.
  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family.
genes like me logo Genes that share domains with CWC27: view

Function for CWC27 Gene

Molecular function for CWC27 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins.

Enzyme Numbers (IUBMB) for CWC27 Gene

genes like me logo Genes that share phenotypes with CWC27: view

Animal Models for CWC27 Gene

MGI Knock Outs for CWC27:

Animal Model Products

miRNA for CWC27 Gene

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CWC27 Gene

Localization for CWC27 Gene

Subcellular locations from

Jensen Localization Image for CWC27 Gene COMPARTMENTS Subcellular localization image for CWC27 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CWC27 Gene

Pathways & Interactions for CWC27 Gene

SuperPathways for CWC27 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CWC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
genes like me logo Genes that share ontologies with CWC27: view

No data available for Pathways by source and SIGNOR curated interactions for CWC27 Gene

Drugs & Compounds for CWC27 Gene

No Compound Related Data Available

Transcripts for CWC27 Gene

Unigene Clusters for CWC27 Gene

CWC27 spliceosome-associated protein homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CWC27 Gene

No ASD Table

Relevant External Links for CWC27 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CWC27 Gene

mRNA expression in normal human tissues for CWC27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CWC27 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.2) and CD8 Tcells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CWC27 Gene

SOURCE GeneReport for Unigene cluster for CWC27 Gene Hs.371372

genes like me logo Genes that share expression patterns with CWC27: view

Protein tissue co-expression partners for CWC27 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CWC27 Gene

Orthologs for CWC27 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CWC27 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CWC27 35
  • 93.15 (n)
  • 93.86 (a)
CWC27 36
  • 94 (a)
(Canis familiaris)
Mammalia CWC27 35
  • 92.57 (n)
  • 93.42 (a)
CWC27 36
  • 93 (a)
(Mus musculus)
Mammalia Cwc27 35
  • 86.47 (n)
  • 91.45 (a)
Cwc27 16
Cwc27 36
  • 91 (a)
(Pan troglodytes)
Mammalia CWC27 35
  • 99.65 (n)
  • 99.36 (a)
CWC27 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cwc27 35
  • 86.08 (n)
  • 90.36 (a)
(Monodelphis domestica)
Mammalia CWC27 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
(Gallus gallus)
Aves CWC27 35
  • 77.3 (n)
  • 78.94 (a)
CWC27 36
  • 78 (a)
(Anolis carolinensis)
Reptilia CWC27 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cwc27 35
  • 71.62 (n)
  • 73.25 (a)
Str.8713 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.13268 35
(Danio rerio)
Actinopterygii cwc27 35
  • 67.24 (n)
  • 71.46 (a)
zgc56702 35
cwc27 36
  • 71 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007704 35
  • 53.94 (n)
  • 53.15 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10907 35
  • 53.08 (n)
  • 51.22 (a)
CG10907 36
  • 46 (a)
(Caenorhabditis elegans)
Secernentea cyn-16 35
  • 53.72 (n)
  • 47.86 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CWC27 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G33060 35
  • 54.31 (n)
  • 48.02 (a)
(Oryza sativa)
Liliopsida Os01g0582400 35
  • 52.26 (n)
  • 48.6 (a)
(Triticum aestivum)
Liliopsida Ta.22856 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4732 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2858 36
  • 53 (a)
Species with no ortholog for CWC27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CWC27 Gene

Gene Tree for CWC27 (if available)
Gene Tree for CWC27 (if available)

Paralogs for CWC27 Gene

Paralogs for CWC27 Gene

(15) SIMAP similar genes for CWC27 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CWC27: view

Variants for CWC27 Gene

Sequence variations from dbSNP and Humsavar for CWC27 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs7735338 - 64,801,318(+) ATGCA(C/G)CAGAT reference, missense
rs719396 -- 64,812,372(-) AAATG(C/T)TCTAG intron-variant
rs725127 -- 64,803,942(+) GCCCG(A/G)GTGAC intron-variant
rs725128 -- 64,803,986(+) GGCAT(G/T)AGTTG intron-variant
rs737137 -- 64,806,807(+) TGGGC(A/G)ACAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CWC27 Gene

Variant ID Type Subtype PubMed ID
dgv6083n71 CNV Gain 21882294
nsv881755 CNV Gain 21882294
esv2632537 CNV Deletion 19546169
esv2678602 CNV Deletion 23128226
nsv881756 CNV Loss 21882294
esv2567621 CNV Deletion 19546169
esv2176429 CNV Deletion 18987734
esv5695 CNV Loss 19470904
esv1006564 CNV Deletion 20482838
esv2441864 CNV Deletion 19546169
esv2730274 CNV Deletion 23290073
nsv330028 CNV Loss 16902084

Variation tolerance for CWC27 Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.39% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CWC27 Gene

Disorders for CWC27 Gene

Relevant External Links for CWC27

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CWC27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CWC27 Gene

Publications for CWC27 Gene

  1. Characterization of human colon cancer antigens recognized by autologous antibodies. (PMID: 9610721) Scanlan M.J. … Old L.J. (Int. J. Cancer 1998) 2 3 4 67
  2. The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome. (PMID: 19941820) Fabrizio P. … LA1hrmann R. (Mol. Cell 2009) 2 3
  3. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for CWC27 Gene

Sources for CWC27 Gene