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Aliases for CWC25 Gene

Aliases for CWC25 Gene

  • CWC25 Spliceosome-Associated Protein Homolog 2 3 5
  • Coiled-Coil Domain-Containing Protein 49 3 4
  • CCDC49 3 4
  • CWC25 Spliceosome-Associated Protein Homolog (S. Cerevisiae) 2
  • Spliceosome-Associated Protein Homolog CWC25 4
  • Coiled-Coil Domain Containing 49 2

External Ids for CWC25 Gene

Previous HGNC Symbols for CWC25 Gene

  • CCDC49

Previous GeneCards Identifiers for CWC25 Gene

  • GC17M036957
  • GC17M032753

Summaries for CWC25 Gene

Entrez Gene Summary for CWC25 Gene

  • This gene encodes a factor that is part of the multi-protein C complex involved in pre-mRNA splicing. Alternatively spliced transcripts have been described for this gene. [provided by RefSeq, Nov 2012]

GeneCards Summary for CWC25 Gene

CWC25 (CWC25 Spliceosome-Associated Protein Homolog) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CWC25 Gene

Genomics for CWC25 Gene

Regulatory Elements for CWC25 Gene

Enhancers for CWC25 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CWC25 on UCSC Golden Path with GeneCards custom track

Promoters for CWC25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CWC25 on UCSC Golden Path with GeneCards custom track

Genomic Location for CWC25 Gene

38,800,434 bp from pter
38,825,481 bp from pter
25,048 bases
Minus strand

Genomic View for CWC25 Gene

Genes around CWC25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CWC25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CWC25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CWC25 Gene

Proteins for CWC25 Gene

  • Protein details for CWC25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pre-mRNA-splicing factor CWC25 homolog
    Protein Accession:
    Secondary Accessions:
    • A0JLM3
    • Q68DK5

    Protein attributes for CWC25 Gene

    425 amino acids
    Molecular mass:
    49647 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CWC25 Gene


neXtProt entry for CWC25 Gene

Proteomics data for CWC25 Gene at MOPED

Post-translational modifications for CWC25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CWC25 Gene

No data available for DME Specific Peptides for CWC25 Gene

Domains & Families for CWC25 Gene

Protein Domains for CWC25 Gene


Suggested Antigen Peptide Sequences for CWC25 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CWC25 family.
  • Belongs to the CWC25 family.
genes like me logo Genes that share domains with CWC25: view

No data available for Gene Families for CWC25 Gene

Function for CWC25 Gene

genes like me logo Genes that share phenotypes with CWC25: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CWC25 Gene

Localization for CWC25 Gene

Subcellular locations from

Jensen Localization Image for CWC25 Gene COMPARTMENTS Subcellular localization image for CWC25 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CWC25 Gene

Pathways & Interactions for CWC25 Gene

SuperPathways for CWC25 Gene

No Data Available

Interacting Proteins for CWC25 Gene

Gene Ontology (GO) - Biological Process for CWC25 Gene


No data available for Pathways by source and SIGNOR curated interactions for CWC25 Gene

Drugs & Compounds for CWC25 Gene

No Compound Related Data Available

Transcripts for CWC25 Gene

Unigene Clusters for CWC25 Gene

CWC25 spliceosome-associated protein homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CWC25 Gene

No ASD Table

Relevant External Links for CWC25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CWC25 Gene

mRNA expression in normal human tissues for CWC25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CWC25 Gene

This gene is overexpressed in Lung (52.4) and Peripheral blood mononuclear cells (16.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CWC25 Gene

SOURCE GeneReport for Unigene cluster for CWC25 Gene Hs.406223

genes like me logo Genes that share expression patterns with CWC25: view

Protein tissue co-expression partners for CWC25 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CWC25 Gene

Orthologs for CWC25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CWC25 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CWC25 35
  • 92.07 (n)
  • 100 (a)
(Canis familiaris)
Mammalia CWC25 35
  • 89.44 (n)
  • 91.43 (a)
(Mus musculus)
Mammalia Cwc25 35
  • 85.82 (n)
  • 90.14 (a)
Cwc25 16
(Pan troglodytes)
Mammalia CWC25 35
  • 99.76 (n)
  • 99.76 (a)
(Rattus norvegicus)
Mammalia Cwc25 35
  • 85.06 (n)
  • 89.88 (a)
(Gallus gallus)
Aves CWC25 35
  • 72.48 (n)
  • 75.54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cwc25 35
  • 65.09 (n)
  • 67.45 (a)
Str.17687 35
African clawed frog
(Xenopus laevis)
Amphibia AF549897-prov 35
(Danio rerio)
Actinopterygii cwc25 35
  • 68.62 (n)
  • 72.51 (a)
Dr.5534 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9008 35
Species with no ortholog for CWC25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CWC25 Gene

Gene Tree for CWC25 (if available)
Gene Tree for CWC25 (if available)

Paralogs for CWC25 Gene

No data available for Paralogs for CWC25 Gene

Variants for CWC25 Gene

Sequence variations from dbSNP and Humsavar for CWC25 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs228243 -- 38,807,300(+) cctgg(A/T)tgaca intron-variant
rs228244 -- 38,807,284(+) cacca(C/T)tgcac intron-variant
rs228245 -- 38,807,277(+) gagat(C/T)gcacc intron-variant
rs228246 -- 38,807,246(+) tgaac(C/T)cagga intron-variant
rs228247 -- 38,807,237(+) agaat(A/C/G/T)gcttg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CWC25 Gene

Variant ID Type Subtype PubMed ID
nsv833438 CNV Loss 17160897
nsv833439 CNV Loss 17160897
esv1005760 CNV Deletion 20482838
nsv827983 CNV Loss 20364138
nsv512485 CNV Loss 21212237
esv2715898 CNV Deletion 23290073
esv2668927 CNV Deletion 23128226
nsv908199 CNV Loss 21882294

Variation tolerance for CWC25 Gene

Residual Variation Intolerance Score: 88.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.50% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CWC25 Gene

Disorders for CWC25 Gene

Relevant External Links for CWC25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CWC25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CWC25 Gene

Publications for CWC25 Gene

  1. The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome. (PMID: 19941820) Fabrizio P. … LA1hrmann R. (Mol. Cell 2009) 2 3 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  4. A comprehensive resource of interacting protein regions for refining human transcription factor networks. (PMID: 20195357) Miyamoto-Sato E. … Yanagawa H. (PLoS ONE 2010) 3
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for CWC25 Gene

Sources for CWC25 Gene