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Aliases for CWC25 Gene

Aliases for CWC25 Gene

  • CWC25 Spliceosome Associated Protein Homolog 2 3 5
  • Coiled-Coil Domain-Containing Protein 49 3 4
  • CCDC49 3 4
  • CWC25 Spliceosome-Associated Protein Homolog (S. Cerevisiae) 2
  • Spliceosome-Associated Protein Homolog CWC25 4
  • Pre-MRNA-Splicing Factor CWC25 Homolog 3
  • Coiled-Coil Domain Containing 49 2

External Ids for CWC25 Gene

Previous HGNC Symbols for CWC25 Gene

  • CCDC49

Previous GeneCards Identifiers for CWC25 Gene

  • GC17M036957
  • GC17M032753

Summaries for CWC25 Gene

Entrez Gene Summary for CWC25 Gene

  • This gene encodes a factor that is part of the multi-protein C complex involved in pre-mRNA splicing. Alternatively spliced transcripts have been described for this gene. [provided by RefSeq, Nov 2012]

GeneCards Summary for CWC25 Gene

CWC25 (CWC25 Spliceosome Associated Protein Homolog) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CWC25 Gene

Genomics for CWC25 Gene

Regulatory Elements for CWC25 Gene

Enhancers for CWC25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F038867 1.6 FANTOM5 ENCODE 16.5 -46.2 -46223 9.2 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 CDK12 ENSG00000266469 MED1 ENSG00000275665 SNORA21 ENSG00000275532 CWC25 LINC02079 PSMB3 ENSG00000252699
GH17F038876 1.3 Ensembl ENCODE 11.3 -56.7 -56668 11.1 PKNOX1 ZFP64 SIN3A ARID4B FEZF1 GLI4 ETS1 ZNF121 GLIS2 SP5 RPL23 RPS20P35 SNORA21 ENSG00000252699 C17orf98 CWC25 PSMB3 LASP1 PCGF2 PPP1R1B
GH17F038895 1.3 Ensembl ENCODE 11.2 -73.9 -73936 7.7 HDGF ATF1 ARNT ZFP64 ARID4B SIN3A YY1 ZNF121 GATA2 FOS SNORA21 MED1 ENSG00000266469 LASP1 ENSG00000275532 RPS20P35 ENSG00000252699 RPL23 ENSG00000275665 CWC25
GH17F038823 1.2 ENCODE 11.5 +0.5 544 3.0 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MED1 ENSG00000266469 CDK12 ENSG00000275532 SNORA21 RPL23 ENSG00000275665 RPL19 PIP4K2B CWC25
GH17F038889 1.2 Ensembl ENCODE 11.3 -66.8 -66817 5.0 PKNOX1 ZFP64 ZNF2 YY1 ZNF766 GATA2 ZNF143 DEK ZNF263 REST LASP1 RPL23 RPS20P35 SNORA21 ENSG00000252699 CWC25 PIP4K2B PSMB3 GC17M038893
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CWC25 on UCSC Golden Path with GeneCards custom track

Promoters for CWC25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001345506 381 1401 CREB3L1 MLX DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 ZNF610

Genomic Location for CWC25 Gene

38,800,434 bp from pter
38,825,481 bp from pter
25,048 bases
Minus strand

Genomic View for CWC25 Gene

Genes around CWC25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CWC25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CWC25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CWC25 Gene

Proteins for CWC25 Gene

  • Protein details for CWC25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pre-mRNA-splicing factor CWC25 homolog
    Protein Accession:
    Secondary Accessions:
    • A0JLM3
    • Q68DK5

    Protein attributes for CWC25 Gene

    425 amino acids
    Molecular mass:
    49647 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CWC25 Gene


neXtProt entry for CWC25 Gene

Post-translational modifications for CWC25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CWC25 Gene

No data available for DME Specific Peptides for CWC25 Gene

Domains & Families for CWC25 Gene

Protein Domains for CWC25 Gene


Suggested Antigen Peptide Sequences for CWC25 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CWC25 family.
  • Belongs to the CWC25 family.
genes like me logo Genes that share domains with CWC25: view

No data available for Gene Families for CWC25 Gene

Function for CWC25 Gene

genes like me logo Genes that share phenotypes with CWC25: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CWC25 Gene

Localization for CWC25 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CWC25 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for CWC25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with CWC25: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CWC25 Gene

Pathways & Interactions for CWC25 Gene

genes like me logo Genes that share pathways with CWC25: view

Pathways by source for CWC25 Gene

Interacting Proteins for CWC25 Gene

Selected Interacting proteins: Q9NXE8-CWC25_HUMAN for CWC25 Gene via IID

Gene Ontology (GO) - Biological Process for CWC25 Gene


No data available for SIGNOR curated interactions for CWC25 Gene

Transcripts for CWC25 Gene

Unigene Clusters for CWC25 Gene

CWC25 spliceosome-associated protein homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CWC25 Gene

No ASD Table

Relevant External Links for CWC25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CWC25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CWC25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CWC25 Gene

This gene is overexpressed in Lung (52.4) and Peripheral blood mononuclear cells (16.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CWC25 Gene

Protein tissue co-expression partners for CWC25 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CWC25 Gene:


SOURCE GeneReport for Unigene cluster for CWC25 Gene:

genes like me logo Genes that share expression patterns with CWC25: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CWC25 Gene

Orthologs for CWC25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CWC25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CWC25 34
  • 99.76 (n)
(Bos Taurus)
Mammalia CWC25 34
  • 92.07 (n)
(Canis familiaris)
Mammalia CWC25 34
  • 89.44 (n)
(Mus musculus)
Mammalia Cwc25 34 16
  • 85.82 (n)
(Rattus norvegicus)
Mammalia Cwc25 34
  • 85.06 (n)
(Gallus gallus)
Aves CWC25 34
  • 72.48 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia cwc25 34
  • 65.09 (n)
Str.17687 34
African clawed frog
(Xenopus laevis)
Amphibia AF549897-prov 34
(Danio rerio)
Actinopterygii cwc25 34
  • 68.62 (n)
Dr.5534 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9008 34
Species where no ortholog for CWC25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CWC25 Gene

Gene Tree for CWC25 (if available)
Gene Tree for CWC25 (if available)

Paralogs for CWC25 Gene

No data available for Paralogs for CWC25 Gene

Variants for CWC25 Gene

Sequence variations from dbSNP and Humsavar for CWC25 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs111344206 -- 38,825,275(+) CTCGC(C/G)GGATC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs111394322 -- 38,814,346(+) TGGCG(C/T)GATCT intron-variant
rs111507123 -- 38,821,468(+) GGCAG(A/G)AGAAT intron-variant
rs111670392 -- 38,801,026(+) GTGAT(C/G)CGCCC nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs111671732 -- 38,827,237(+) GAAAG(-/AA)AAACA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CWC25 Gene

Variant ID Type Subtype PubMed ID
nsv833439 CNV loss 17160897
nsv833438 CNV loss 17160897
nsv827983 CNV loss 20364138
nsv512485 CNV loss 21212237
nsv1153975 CNV deletion 26484159
nsv1146669 OTHER inversion 26484159
esv3640530 CNV loss 21293372
esv3554396 CNV deletion 23714750
esv3554395 CNV deletion 23714750
esv2715898 CNV deletion 23290073
esv2668927 CNV deletion 23128226
esv1005760 CNV deletion 20482838

Variation tolerance for CWC25 Gene

Residual Variation Intolerance Score: 88.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CWC25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CWC25 Gene

Disorders for CWC25 Gene

Relevant External Links for CWC25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CWC25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CWC25 Gene

Publications for CWC25 Gene

  1. The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome. (PMID: 19941820) Fabrizio P. … LA1hrmann R. (Mol. Cell 2009) 2 3 64
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3 64
  5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 4 64

Products for CWC25 Gene

Sources for CWC25 Gene

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