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Aliases for CWC25 Gene

Aliases for CWC25 Gene

  • CWC25 Spliceosome Associated Protein Homolog 2 3 5
  • Coiled-Coil Domain-Containing Protein 49 3 4
  • CCDC49 3 4
  • CWC25 Spliceosome-Associated Protein Homolog (S. Cerevisiae) 2
  • Spliceosome-Associated Protein Homolog CWC25 4
  • Pre-MRNA-Splicing Factor CWC25 Homolog 3
  • Coiled-Coil Domain Containing 49 2

External Ids for CWC25 Gene

Previous HGNC Symbols for CWC25 Gene

  • CCDC49

Previous GeneCards Identifiers for CWC25 Gene

  • GC17M036957
  • GC17M032753

Summaries for CWC25 Gene

Entrez Gene Summary for CWC25 Gene

  • This gene encodes a factor that is part of the multi-protein C complex involved in pre-mRNA splicing. Alternatively spliced transcripts have been described for this gene. [provided by RefSeq, Nov 2012]

GeneCards Summary for CWC25 Gene

CWC25 (CWC25 Spliceosome Associated Protein Homolog) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression.

Additional gene information for CWC25 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CWC25 Gene

Genomics for CWC25 Gene

Regulatory Elements for CWC25 Gene

Enhancers for CWC25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H038867 1.8 FANTOM5 ENCODE dbSUPER 16.6 -46.2 -46223 9.2 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC SSRP1 MED1 CDK12 LOC105371762 SNORA21 RPL23 CWC25 PSMB3 LINC02079 SNORA21B C17orf98
GH17H038895 1.5 Ensembl ENCODE dbSUPER 11.3 -73.9 -73936 7.7 HDGF PKNOX1 ATF1 ARNT ZFP64 ARID4B SIN3A TCF12 ZNF121 ZNF766 SNORA21 MED1 LASP1 RPS20P35 RPL23 SNORA21B LOC105371762 CWC25 LINC00672 ENSG00000266588
GH17H038876 1.5 Ensembl ENCODE dbSUPER 11.3 -56.7 -56668 11.1 ARNT ZFP64 ARID4B FEZF1 GLI4 YY1 ETS1 GLIS2 RUNX3 SP5 SNORA21 MED1 RPL23 RPS20P35 SNORA21B C17orf98 CWC25 PSMB3 LASP1 PCGF2
GH17H038920 1.4 Ensembl ENCODE dbSUPER 10.9 -96.7 -96745 3.1 ZFP64 PAF1 ZNF202 ZNF654 ZC3H11A REST ZNF518A ZNF781 ZNF623 ZNF292 MED1 CDK12 SNORA21 LOC105371762 RPL23 FBXO47 C17orf98 CWC25 PIP4K2B RPL19
GH17H038925 1.4 Ensembl ENCODE dbSUPER 10.6 -100.6 -100606 2.1 HDAC1 PKNOX1 TBL1XR1 ARNT TCF12 ZNF766 ETV6 ATF7 RUNX3 IKZF2 ENSG00000266588 FBXO47 C17orf98 PIP4K2B CWC25 LINC00672 GC17M038934
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CWC25 on UCSC Golden Path with GeneCards custom track

Promoters for CWC25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000093818 281 1201 MLX DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A ZNF610 RCOR2 NBN

Genomic Locations for CWC25 Gene

Genomic Locations for CWC25 Gene
25,048 bases
Minus strand

Genomic View for CWC25 Gene

Genes around CWC25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CWC25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CWC25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CWC25 Gene

Proteins for CWC25 Gene

  • Protein details for CWC25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pre-mRNA-splicing factor CWC25 homolog
    Protein Accession:
    Secondary Accessions:
    • A0JLM3
    • Q68DK5

    Protein attributes for CWC25 Gene

    425 amino acids
    Molecular mass:
    49647 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CWC25 Gene


neXtProt entry for CWC25 Gene

Post-translational modifications for CWC25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CWC25 Gene

No data available for DME Specific Peptides for CWC25 Gene

Domains & Families for CWC25 Gene

Gene Families for CWC25 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CWC25 Gene


Suggested Antigen Peptide Sequences for CWC25 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CWC25 family.
  • Belongs to the CWC25 family.
genes like me logo Genes that share domains with CWC25: view

Function for CWC25 Gene

Phenotypes From GWAS Catalog for CWC25 Gene

genes like me logo Genes that share phenotypes with CWC25: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CWC25 Gene

Localization for CWC25 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CWC25 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CWC25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with CWC25: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CWC25 Gene

Pathways & Interactions for CWC25 Gene

genes like me logo Genes that share pathways with CWC25: view

Pathways by source for CWC25 Gene

Interacting Proteins for CWC25 Gene

Selected Interacting proteins: Q9NXE8-CWC25_HUMAN for CWC25 Gene via IID

Gene Ontology (GO) - Biological Process for CWC25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
genes like me logo Genes that share ontologies with CWC25: view

No data available for SIGNOR curated interactions for CWC25 Gene

Drugs & Compounds for CWC25 Gene

No Compound Related Data Available

Transcripts for CWC25 Gene

Unigene Clusters for CWC25 Gene

CWC25 spliceosome-associated protein homolog (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CWC25 Gene

No ASD Table

Relevant External Links for CWC25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CWC25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CWC25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CWC25 Gene

This gene is overexpressed in Lung (52.4) and Peripheral blood mononuclear cells (16.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CWC25 Gene

Protein tissue co-expression partners for CWC25 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CWC25 Gene:


SOURCE GeneReport for Unigene cluster for CWC25 Gene:


Evidence on tissue expression from TISSUES for CWC25 Gene

  • Liver(4.2)
  • Eye(4.1)
  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with CWC25: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CWC25 Gene

Orthologs for CWC25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CWC25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CWC25 33
  • 99.76 (n)
(Bos Taurus)
Mammalia CWC25 33
  • 92.07 (n)
(Canis familiaris)
Mammalia CWC25 33
  • 89.44 (n)
(Mus musculus)
Mammalia Cwc25 33 16
  • 85.82 (n)
(Rattus norvegicus)
Mammalia Cwc25 33
  • 85.06 (n)
(Gallus gallus)
Aves CWC25 33
  • 72.48 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia cwc25 33
  • 65.09 (n)
Str.17687 33
African clawed frog
(Xenopus laevis)
Amphibia AF549897-prov 33
(Danio rerio)
Actinopterygii cwc25 33
  • 68.62 (n)
Dr.5534 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9008 33
Species where no ortholog for CWC25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CWC25 Gene

Gene Tree for CWC25 (if available)
Gene Tree for CWC25 (if available)

Paralogs for CWC25 Gene

No data available for Paralogs for CWC25 Gene

Variants for CWC25 Gene

Sequence variations from dbSNP and Humsavar for CWC25 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000024146 -- 38,821,781(+) TCATT(C/T)TTTTT intron-variant
rs1000075967 -- 38,806,647(+) AAATA(C/G)CAAAG intron-variant
rs1000233873 -- 38,803,318(+) AAGGA(-/AT)ATAAC intron-variant
rs1000267166 -- 38,823,031(+) AGACG(A/G)GTTTC intron-variant
rs1000370195 -- 38,810,649(+) GCGCA(C/G)TGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CWC25 Gene

Variant ID Type Subtype PubMed ID
nsv833439 CNV loss 17160897
nsv833438 CNV loss 17160897
nsv827983 CNV loss 20364138
nsv512485 CNV loss 21212237
nsv1153975 CNV deletion 26484159
nsv1146669 OTHER inversion 26484159
esv3640530 CNV loss 21293372
esv3554396 CNV deletion 23714750
esv3554395 CNV deletion 23714750
esv2715898 CNV deletion 23290073
esv2668927 CNV deletion 23128226
esv1005760 CNV deletion 20482838

Variation tolerance for CWC25 Gene

Residual Variation Intolerance Score: 88.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CWC25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CWC25 Gene

Disorders for CWC25 Gene

Relevant External Links for CWC25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CWC25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CWC25 Gene

Publications for CWC25 Gene

  1. The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome. (PMID: 19941820) Fabrizio P … Lührmann R (Molecular cell 2009) 2 3 60
  2. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60
  3. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 60

Products for CWC25 Gene

Sources for CWC25 Gene

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