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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CWC22 Gene

protein-coding   GIFtS: 50
GCID: GC02M180809

CWC22 Spliceosome-Associated Protein Homolog (S. Cerevisiae)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CWC22 Spliceosome-Associated Protein Homolog (S. Cerevisiae)1 2     fSAPb2 3
Functional Spliceosome-Associated Protein B1 2     EIF4GL2
Nucampholin Homolog2 3     Pre-MRNA-Splicing Factor CWC22 Homolog2
NCM2 3     KIAA16043

External Ids:    HGNC: 293221   Entrez Gene: 577032   Ensembl: ENSG000001635107   OMIM: 6151865   UniProtKB: Q9HCG83   

Export aliases for CWC22 gene to outside databases

Previous GC identifers: GC02M180518 GC02M172661


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CWC22 Gene: 
CWC22 (CWC22 spliceosome-associated protein homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with CWC22 include cerebral malaria, and malaria. GO annotations related to this gene include RNA binding and DNA binding.

UniProtKB/Swiss-Prot: CWC22_HUMAN, Q9HCG8
Function: May be involved in pre-mRNA splicing




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CWC22 gene promoter:
         Bach1   STAT5B   RelA   c-Ets-1   E47   C/EBPalpha   Pax-3   S8   MRF-2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCWC22 promoter sequence
   Search SABiosciences Chromatin IP Primers for CWC22

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CWC22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.3   Ensembl cytogenetic band:  2q31.3   HGNC cytogenetic band: 2q31.3

CWC22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CWC22 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M180809:  view genomic region     (about GC identifiers)

Start:
180,809,603 bp from pter      End:
180,871,840 bp from pter
Size:
62,238 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CWC22_HUMAN, Q9HCG8 (See protein sequence)
Recommended Name: Pre-mRNA-splicing factor CWC22 homolog  
Size: 908 amino acids; 105466 Da
Subunit: Component of the spliceosome C complex
Subcellular location: Nucleus
Sequence caution: Sequence=AAH16651.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH31216.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH57826.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAB13430.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB15197.1; Type=Frameshift; Positions=555; Sequence=BAB15612.1; Type=Erroneous initiation;
Note=Translation N-terminally extended;
Secondary accessions: Q05DC2 Q4G135 Q52LF0 Q6PEX2 Q7Z6I0 Q9H5L3 Q9H6Q6

Explore the universe of human proteins at neXtProt for CWC22: NX_Q9HCG8

Explore proteomics data for CWC22 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HCG8

  • CWC22 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CWC22 Protein Expression
    REFSEQ proteins: NP_065994.1  
    ENSEMBL proteins: 
     ENSP00000387006   ENSP00000384159   ENSP00000295749  

    Human Recombinant Protein Products for CWC22: 
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    Novus Biologicals CWC22 Protein
    Novus Biologicals CWC22 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005681spliceosomal complex IDA11991638
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0016607nuclear speck IDA--

    CWC22 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR003890 MIF4G-like_typ-3
     IPR016021 MIF4-like_typ_1/2/3
     IPR003891 Initiation_fac_eIF4g_MI
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9HCG8

    ProtoNet protein and cluster: Q9HCG8

    2 Blocks protein domains:
    IPB003890 Initiation factor eIF-4 gamma
    IPB003891 Initiation factor eIF-4 gamma


    UniProtKB/Swiss-Prot: CWC22_HUMAN, Q9HCG8
    Similarity: Belongs to the CWC22 family
    Similarity: Contains 1 MI domain
    Similarity: Contains 1 MIF4G domain


    CWC22 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CWC22_HUMAN, Q9HCG8
    Function: May be involved in pre-mRNA splicing

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003723RNA binding IDA11991638
    GO:0005488binding ----
    GO:0005515protein binding IPI--
         
    CWC22 for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for CWC22:
     Cell cycle / mitosis defect  Cell division defect  Decreased homologous recombina  Decreased influenza A virus in 
     Decreased viability of wild-ty  Increased S DNA content, incre  Increased number of mitotic ce 

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CWC22 
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    miRNA
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    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate CWC22 (see all 12):
    hsa-miR-3671 hsa-miR-3163 hsa-miR-142-5p hsa-miR-3910 hsa-miR-520d-5p hsa-miR-300 hsa-miR-381 hsa-miR-4299
    SwitchGear 3'UTR luciferase reporter plasmidCWC22 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CWC22


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CWC22

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/79 Interacting proteins for CWC22 (Q9HCG82, 3 ENSP000003870064) via UniProtKB, MINT, STRING, and/or I2D (see all 79)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DHX15O431432, 3MINT-8173832 I2D: score=1 
    PRPF6O949062, 3MINT-8173832 I2D: score=1 
    ENSG00000172850Q9Y3333I2D: score=1 
    ENSG00000224979Q9Y3333I2D: score=1 
    ENSG00000225998Q9Y3333I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome IC11991638
    GO:0016070RNA metabolic process ----
    GO:0048024regulation of mRNA splicing, via spliceosome IC11991638

    CWC22 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CWC22

    Search CenterWatch for drugs/clinical trials and news about CWC22

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CWC22 gene: 
    NM_020943.2  

    Unigene Cluster for CWC22:

    CWC22 spliceosome-associated protein homolog (S. cerevisiae)
    Hs.311363  [show with all ESTs]
    Unigene Representative Sequence: NM_020943
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000410053(uc002uno.2 uc010frh.1 uc002unp.2) ENST00000404136
    ENST00000295749
    miRNA
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    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate CWC22 (see all 12):
    hsa-miR-3671 hsa-miR-3163 hsa-miR-142-5p hsa-miR-3910 hsa-miR-520d-5p hsa-miR-300 hsa-miR-381 hsa-miR-4299
    SwitchGear 3'UTR luciferase reporter plasmidCWC22 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CWC22
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CWC22

    Additional mRNA sequence: 

    AB046824.1 AK025635.1 AK026978.1 AK123647.1 BC016651.1 BC031216.1 BC041662.1 BC053573.1 
    BC057826.1 BC093952.1 BC093954.1 BC143433.1 

    10 DOTS entries:

    DT.211201  DT.99983334  DT.101975253  DT.120931954  DT.95250819  DT.100773709  DT.101966534  DT.120931886 
    DT.120931967  DT.75148834 

    24/105 AceView cDNA sequences (see all 105):

    AI753518 BI789127 BI789261 AW512450 AW069200 BU182838 BI962595 AA236786 
    BG030824 CK821194 AB046824 AI624885 BG231878 AA293258 BE550345 CK821193 
    AV716187 AI580093 CR616945 BC016651 BE464084 BI962772 BQ435052 AA713496 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CWC22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CWC22 Expression
    About this image


    See CWC22 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CWC22

    SOURCE GeneReport for Unigene cluster: Hs.311363
        SABiosciences Custom PCR Arrays for CWC22
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CWC22

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CWC22 gene from 10/27 species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cwc221 , 5 CWC22 spliceosome-associated protein homolog (S. cerevisiae)1, 5 82.46(n)1
    84.87(a)1
      2 (46.45 cM)5
    807441  NM_030560.41  NP_085037.21 
     778811595 
    chicken
    (Gallus gallus)
    Aves CWC221 CWC22 spliceosome-associated protein homolog (S. cerevisiae) 73.84(n)
    75.82(a)
      424123  NM_001031250.1  NP_001026421.1 
    lizard
    (Anolis carolinensis)
    Reptilia CWC226
    CWC22 spliceosome-associated protein homolog (S. c...
    71(a)
    1 ↔ 1
    GL343531.1(341426-382463)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.144162 Xenopus laevis transcribed sequence with weak similarity more 78.46(n)    BJ060536.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cwc221 CWC22 spliceosome-associated protein homolog (S. cerevisiae) 64.29(n)
    68.57(a)
      566033  NM_001077569.1  NP_001071037.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ncm1 nucampholin 52.97(n)
    51.87(a)
      35099  NM_136033.2  NP_609877.2 
    worm
    (Caenorhabditis elegans)
    Secernentea let-8581 Protein LET-858 53.54(n)
    51.36(a)
      174689  NM_063962.5  NP_496363.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CWC22(YGR278W)4
    CWC221
    Spliceosome-associated protein that is required for more4
    Cwc22p1
    44.15(n)1
    30.29(a)1
      7(1046731-1048464)4
    8531951, 4  NP_011794.31  NP_011794.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G809301 pre-mRNA-splicing factor CWC22 57.22(n)
    53.86(a)
      844433  NM_106741.2  NP_178208.1 
    rice
    (Oryza sativa)
    Liliopsida Os.210312 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 71.53(n)    AK103658.1 


    ENSEMBL Gene Tree for CWC22 (if available)
    TreeFam Gene Tree for CWC22 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1213 SNPs in CWC22 are shown (see all 1213)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs64338151,2
    C,F,A,H--180809116(+) CACAAT/CTATAT 1 -- ds500125Minor allele frequency- C:0.37NA NS EA WA 2488
    rs1808032851,2
    --180809162(+) AAATAC/TACATT 1 -- ds50010--------
    rs64338161,2
    C,F,H--180809317(+) AAAGAC/GTAACA 1 -- ds500119Minor allele frequency- G:0.05NA NS EA WA CSA 816
    rs107183081,2
    C--180809415(+) TACTG-/AAAAAA 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs168671121,2
    C,F,H--180809529(+) AGCACT/AGATAA 1 -- ds500118Minor allele frequency- A:0.15NA EA NS WA 2234
    rs1143280701,2
    F--180809622(+) TTTTAT/CTCACA 1 -- ut311Minor allele frequency- C:0.01NA 120
    rs1857368811,2
    --180809705(+) TATCAA/GTTATA 1 -- ut310--------
    rs2018746771,2
    C--180809957(+) TCTCTC/TGGCAC 2 K E mis10--------
    rs1904765251,2
    C--180809986(+) CATCAC/TTTCTT 2 N S mis10--------
    rs64338171,2
    C,F,A--180810180(+) TCATTT/CGCAAC 2 /A syn115Minor allele frequency- C:0.34NA NS WA CSA EA EU 1181

    HapMap Linkage Disequilibrium report for CWC22 (180809603 - 180871840 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CWC22:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv834473CNV Gain17160897
    dgv4376n71CNV Gain21882294
    nsv521134CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CWC22
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 615186    OMIM disorders: --

    3 diseases for CWC22:    About MalaCards
    cerebral malaria    malaria    cerebritis


    CWC22 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CWC22
    Human Genome Epidemiology (HuGE) Navigator: CWC22 (1 document)

    Export disorders for CWC22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CWC22 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with CWC22)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide search for loci interacting with known p rostate cancer risk-associated genetic variants. (PubMed id 22219177)1, 4 Tao S....Sun J. (2012)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (2002)
    5. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (2000)
    6. Distinct requirements for somatic and germline expression of a generally expressed Caernorhabditis elegans gene. (PubMed id 9136012)1, 3 Kelly W.G....Fire A. (1997)
    7. Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (2012)
    8. Dynamic protein-protein interaction wiring of the huma n spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (2012)
    9. Human spliceosomal protein CWC22 plays a role in coupl ing splicing to exon junction complex deposition and nonsense-mediated decay. (PubMed id 23236153)1 Alexandrov A....Steitz J.A. (2012)
    10. Human CWC22 escorts the helicase eIF4AIII to spliceoso mes and promotes exon junction complex assembly. (PubMed id 22961380)1 Barbosa I....Le Hir H. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57703 HGNC: 29322 AceView: KIAA1604 Ensembl:ENSG00000163510 euGenes: HUgn57703
    ECgene: CWC22 H-InvDB: CWC22

    (According to HUGE)
    About This Section
    HUGE: KIAA1604

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CWC22 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CWC22 gene:
    Search GeneIP for patents involving CWC22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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