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CWC22 Gene

protein-coding   GIFtS: 50
GCID: GC02M180809

CWC22 Spliceosome-Associated Protein Homolog (S. Cerevisiae)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CWC22 Spliceosome-Associated Protein Homolog (S. Cerevisiae)1 2     KIAA16043 5
NCM2 3 5     EIF4GL2
Functional Spliceosome-Associated Protein B1 2     Pre-MRNA-Splicing Factor CWC22 Homolog2
Nucampholin Homolog2 3     CWC25
fSAPb2 3     

External Ids:    HGNC: 293221   Entrez Gene: 577032   Ensembl: ENSG000001635107   OMIM: 6151865   UniProtKB: Q9HCG83   

Export aliases for CWC22 gene to outside databases

Previous GC identifers: GC02M180518 GC02M172661


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CWC22 Gene:
CWC22 (CWC22 spliceosome-associated protein homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with CWC22 include cerebral malaria, and malaria. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: CWC22_HUMAN, Q9HCG8
Function: Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from
non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs.
Through its role in EJC assembly, required for nonsense-mediated mRNA decay




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CWC22 gene promoter:
         Bach1   STAT5B   RelA   c-Ets-1   E47   C/EBPalpha   Pax-3   S8   MRF-2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCWC22 promoter sequence
   Search Chromatin IP Primers for CWC22

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CWC22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.3   Ensembl cytogenetic band:  2q31.3   HGNC cytogenetic band: 2q31.3

CWC22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CWC22 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M180809:  view genomic region     (about GC identifiers)

Start:
180,809,603 bp from pter      End:
180,871,840 bp from pter
Size:
62,238 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CWC22_HUMAN, Q9HCG8 (See protein sequence)
Recommended Name: Pre-mRNA-splicing factor CWC22 homolog  
Size: 908 amino acids; 105466 Da
Subunit: Component of the spliceosome C complex. Interacts with EIF4A3 and PRPF19 in an RNA-independent manner.
Direct interaction with EIF4A3 is mediated by the MIF4G domain. Full interaction with EIF4A3 occurs only when
EIF4A3 is not part of the EJC and prevents EIF4A3 binding to RNA
Sequence caution: Sequence=AAH16651.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH31216.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH57826.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAB13430.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB15197.1; Type=Frameshift; Positions=555; Sequence=BAB15612.1; Type=Erroneous initiation;
Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for CWC22:
4C9B (3D)    
Secondary accessions: Q05DC2 Q4G135 Q52LF0 Q6PEX2 Q7Z6I0 Q9H5L3 Q9H6Q6

Explore the universe of human proteins at neXtProt for CWC22: NX_Q9HCG8

Explore proteomics data for CWC22 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CWC22 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065994.1  
    ENSEMBL proteins: 
     ENSP00000387006   ENSP00000384159   ENSP00000295749  

    CWC22 Human Recombinant Protein Products:

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    Novus Biologicals CWC22 Protein
    Novus Biologicals CWC22 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    CWC22 Antibody Products:

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    CWC22 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR003890 MIF4G-like_typ-3
     IPR016021 MIF4-like_typ_1/2/3
     IPR003891 Initiation_fac_eIF4g_MI
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9HCG8

    ProtoNet protein and cluster: Q9HCG8

    2 Blocks protein domains:
    IPB003890 Initiation factor eIF-4 gamma
    IPB003891 Initiation factor eIF-4 gamma


    UniProtKB/Swiss-Prot: CWC22_HUMAN, Q9HCG8
    Similarity: Belongs to the CWC22 family
    Similarity: Contains 1 MI domain
    Similarity: Contains 1 MIF4G domain


    CWC22 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CWC22_HUMAN, Q9HCG8
    Function: Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from
    non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs.
    Through its role in EJC assembly, required for nonsense-mediated mRNA decay

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IDA11991638
    GO:0005488binding ----
    GO:0005515protein binding IPI--
         
    CWC22 for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for CWC22:
     Cell cycle / mitosis defect  Cell division defect  Decreased homologous recombina  Decreased influenza A virus in 
     Decreased viability of wild-ty  Increased S DNA content, incre  Increased number of mitotic ce 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CWC22
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    miRNA
    Products:
        
    miRTarBase miRNAs that target CWC22:
    hsa-mir-484 (MIRT041798), hsa-mir-615-3p (MIRT039856), hsa-mir-877-3p (MIRT037138)

    Block miRNA regulation of human, mouse, rat CWC22 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CWC22 (see all 12):
    hsa-miR-3671 hsa-miR-3163 hsa-miR-142-5p hsa-miR-3910 hsa-miR-520d-5p hsa-miR-300 hsa-miR-381 hsa-miR-4299
    SwitchGear 3'UTR luciferase reporter plasmidCWC22 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CWC22
    Predesigned siRNA for gene silencing in human, mouse, rat CWC22

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for CWC22
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    GenScript: all cDNA clones in your preferred vector: CWC22 (NM_020943)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CWC22

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    Browse ESI BIO Cell Lines and PureStem Progenitors for CWC22 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CWC22


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CWC22_HUMAN, Q9HCG8: Nucleus. Nucleus speckle. Note=Concentrates around speckles, which are sites of pre-mRNA
    synthesis and processing, where it colocalizes with EJC core proteins
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005681spliceosomal complex IDA11991638
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0016607nuclear speck IDA--

    CWC22 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CWC22
    Interactions:

        Search GeneGlobe Interaction Network for CWC22

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CWC22 (Q9HCG81, 2, 3 ENSP000003870064) via UniProtKB, MINT, STRING, and/or I2D (see all 144)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FAM32AQ9Y4211, 2, ENSP000002633844EBI-373289,EBI-726146 MINT-8332020 MINT-8337706 STRING: ENSP00000263384
    FRG1Q143311, 2, ENSP000002267984EBI-373289,EBI-2515248 MINT-8332009 MINT-8337695 STRING: ENSP00000226798
    DHX15O431432, 3, ENSP000003367414MINT-8173832 I2D: score=1 STRING: ENSP00000336741
    PRPF6O949062, 3MINT-8173832 I2D: score=1 
    ENSG00000172850Q9Y3333I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome IC11991638
    GO:0048024regulation of mRNA splicing, via spliceosome IC11991638

    CWC22 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CWC22



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CWC22 gene: 
    NM_020943.2  

    Unigene Cluster for CWC22:

    CWC22 spliceosome-associated protein homolog (S. cerevisiae)
    Hs.311363  [show with all ESTs]
    Unigene Representative Sequence: NM_020943
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000410053(uc002uno.2 uc010frh.1 uc002unp.2) ENST00000404136
    ENST00000295749
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CWC22 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CWC22 (see all 12):
    hsa-miR-3671 hsa-miR-3163 hsa-miR-142-5p hsa-miR-3910 hsa-miR-520d-5p hsa-miR-300 hsa-miR-381 hsa-miR-4299
    SwitchGear 3'UTR luciferase reporter plasmidCWC22 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CWC22
    Clone
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    OriGene clones in human, mouse for CWC22 (see all 6)
    OriGene ORF clones in mouse, rat for CWC22
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CWC22 (NM_020943)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CWC22
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CWC22
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CWC22
      QuantiTect SYBR Green Assays in human, mouse, rat CWC22
      QuantiFast Probe-based Assays in human, mouse, rat CWC22

    Additional mRNA sequence: 

    AB046824.1 AK025635.1 AK026978.1 AK123647.1 BC016651.1 BC031216.1 BC041662.1 BC053573.1 
    BC057826.1 BC093952.1 BC093954.1 BC143433.1 

    10 DOTS entries:

    DT.211201  DT.99983334  DT.101975253  DT.120931954  DT.95250819  DT.100773709  DT.101966534  DT.120931886 
    DT.120931967  DT.75148834 

    Selected AceView cDNA sequences (see all 105):

    CK821194 BI789261 AI753518 BG030824 BC057826 BU165349 BE550345 CK821193 
    AV716187 AI580093 CR616945 BC016651 BE464084 BI962772 BQ435052 AA713496 
    AI925345 BI962595 BI789127 BU182838 AA293258 BG231878 AI624885 BU676271 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CWC22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CWC22 Expression
    About this image

    CWC22 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CWC22 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.311363
        Custom PCR Arrays for CWC22
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CWC22

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CWC22 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cwc221 , 5 CWC22 spliceosome-associated protein homolog (S. cerevisiae)1, 5 81.37(n)1
    83.22(a)1
      2 (46.45 cM)5
    807441  NM_030560.41  NP_085037.21 
     778811595 
    chicken
    (Gallus gallus)
    Aves CWC221 CWC22 spliceosome-associated protein homolog (S. cerevisiae) 73(n)
    75.19(a)
      424123  NM_001031250.1  NP_001026421.1 
    lizard
    (Anolis carolinensis)
    Reptilia CWC226
    CWC22 spliceosome-associated protein homolog (S. c...
    72(a)
    1 ↔ 1
    GL343531.1(341426-382463)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.144162 Xenopus laevis transcribed sequence with weak similarity more 78.46(n)    BJ060536.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cwc221 CWC22 spliceosome-associated protein homolog (S. cerevisiae) 64.12(n)
    70.15(a)
      566033  NM_001077569.1  NP_001071037.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ncm6
    nucampholin
    35(a)
    1 ↔ 1
    2L(18444507-18448957)
    worm
    (Caenorhabditis elegans)
    Secernentea let-8586
    Protein LET-858 (let-858) mRNA, complete cds
    42(a)
    1 ↔ 1
    II(11022370-11027920) WBGene00002957
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CWC22(YGR278W)4
    CWC221
    Spliceosome-associated protein that is required for more4
    CWC221
    46.33(n)1
    32.84(a)1
      7(1046731-1048464)4
    8531951, 4  NP_011794.31  NP_011794.14 
    soybean
    (Glycine max)
    eudicotyledons Gma.89112 Transcribed sequence with moderate similarity to protein more 76.04(n)  
    rice
    (Oryza sativa)
    Liliopsida Os.210312 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 71.53(n)    AK103658.1 


    ENSEMBL Gene Tree for CWC22 (if available)
    TreeFam Gene Tree for CWC22 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CWC22 (see all 1213)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs64338151,2
    C,F,A,H--180809116(+) CACAAT/CTATAT 1 -- ds500125Minor allele frequency- C:0.37NA NS EA WA 2488
    rs1808032851,2
    --180809162(+) AAATAC/TACATT 1 -- ds50010--------
    rs64338161,2
    C,F,H--180809317(+) AAAGAC/GTAACA 1 -- ds500119Minor allele frequency- G:0.05NA NS EA WA CSA 816
    rs107183081,2
    C--180809415(+) TACTG-/AAAAAA 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs168671121,2
    C,F,H--180809529(+) AGCACT/AGATAA 1 -- ds500118Minor allele frequency- A:0.15NA EA NS WA 2234
    rs1143280701,2
    F--180809622(+) TTTTAT/CTCACA 1 -- ut311Minor allele frequency- C:0.01NA 120
    rs1857368811,2
    --180809705(+) TATCAA/GTTATA 1 -- ut310--------
    rs2018746771,2
    C--180809957(+) TCTCTC/TGGCAC 2 K E mis10--------
    rs1904765251,2
    C--180809986(+) CATCAC/TTTCTT 2 N S mis10--------
    rs64338171,2
    C,F,A--180810180(+) TCATTT/CGCAAC 2 /A syn115Minor allele frequency- C:0.34NA NS WA CSA EA EU 1181

    HapMap Linkage Disequilibrium report for CWC22 (180809603 - 180871840 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CWC22:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834473CNV Gain17160897
    dgv4376n71CNV Gain21882294
    nsv521134CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CWC22
    DNA2.0 Custom Variant and Variant Library Synthesis for CWC22

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615186    OMIM disorders: --

    10 diseases for CWC22:    
    About MalaCards
    cerebral malaria    malaria    cerebritis    systemic lupus erythematosus
    asthma    lupus erythematosus    atherosclerosis    obesity
    prostate cancer    prostatitis


    CWC22 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CWC22
    Human Genome Epidemiology (HuGE) Navigator: CWC22 (1 document)

    Export disorders for CWC22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CWC22 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with CWC22)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PubMed id 22219177)1, 4 Tao S....Sun J. (Carcinogenesis 2012)
    2. Human spliceosomal protein CWC22 plays a role in coupling splicing to exon junction complex deposition and nonsense-mediated decay. (PubMed id 23236153)1, 2 Alexandrov A....Steitz J.A. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    3. Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly. (PubMed id 22961380)1, 2 Barbosa I....Le Hir H. (amp 2012)
    4. CWC22 connects pre-mRNA splicing and exon junction complex assembly. (PubMed id 22959432)1, 2 Steckelberg A.L....Gehring N.H. (Cell Rep 2012)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)
    8. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    9. Distinct requirements for somatic and germline expression of a generally expressed Caernorhabditis elegans gene. (PubMed id 9136012)1, 3 Kelly W.G....Fire A. (Genetics 1997)
    10. Crystal structure of the human eIF4AIII-CWC22 complex shows how a DEAD-box protein is inhibited by a MIF4G domain. (PubMed id 24218557)1 Buchwald G....Conti E. (Proc. Natl. Acad. Sci. U.S.A. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57703 HGNC: 29322 AceView: KIAA1604 Ensembl:ENSG00000163510 euGenes: HUgn57703
    ECgene: CWC22 H-InvDB: CWC22

    (According to HUGE)
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    HUGE: KIAA1604

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CWC22 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CWC22 gene:
    Search GeneIP for patents involving CWC22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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