CWC22 Gene
protein-coding GIFtS: 47
GCID: GC02M180809
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CWC22 spliceosome-associated protein homolog (S. cerevisiae)
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Aliases
for CWC22 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CWC22 Spliceosome-Associated Protein Homolog (S. Cerevisiae)1 2 | | KIAA16041 3 | | NCM1 2 3 | | Nucampholin Homolog2 3 | | FSAPb1 | | Functional Spliceosome-Associated Protein B2 | | EIF4GL1 2 | | Pre-MRNA-Splicing Factor CWC22 Homolog2 |
Export aliases for CWC22 gene to outside databasesPrevious GC identifers: GC02M180518 GC02M172661 |
Summaries
for CWC22 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CWC22_HUMAN, Q9HCG8Function: May be involved in pre-mRNA splicing
|
Genomic Views
for CWC22 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CWC22 gene promoter:
Bach1 STAT5B RelA c-Ets-1 E47 C/EBPalpha Pax-3 S8 MRF-2 Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CWC22
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CWC22 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q31.3 Ensembl cytogenetic band: 2q31.3 HGNC cytogenetic band: 2q31.3CWC22 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M180809: view genomic region
(about GC identifiers)
Start:
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180,809,603 bp from pter |
End:
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180,871,840 bp from pter |
Size:
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62,238 bases |
Orientation:
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minus strand |
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Proteins
for CWC22 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CWC22_HUMAN, Q9HCG8 (See
protein sequence)Recommended Name: Pre-mRNA-splicing factor CWC22 homolog Size: 908 amino acids; 105466 Da
Subunit: Component of the spliceosome C complex
Subcellular location: Nucleus
Sequence caution: Sequence=AAH16651.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence; Sequence=AAH31216.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;Sequence=AAH57826.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;Sequence=BAB13430.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAB15197.1;Type=Frameshift; Positions=555; Sequence=BAB15612.1; Type=Erroneous initiation; Note=Translation N-terminallyextended;
Secondary accessions: Q05DC2 Q4G135 Q52LF0 Q6PEX2 Q7Z6I0 Q9H5L3 Q9H6Q6Explore the universe of human proteins at neXtProt for CWC22: NX_Q9HCG8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9HCG8
CWC22 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065994.1
ENSEMBL proteins: ENSP00000387006 ENSP00000384159 ENSP00000295749
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
CWC22 for ontologies About GeneDecksing
CWC22 Antibody Products:
Assay Products for CWC22: |
Protein
Domains /
Families
for CWC22 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CWC22 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9HCG8ProtoNet protein and cluster: Q9HCG8 2 Blocks protein families: IPB003890 Initiation factor eIF-4 gamma IPB003891 Initiation factor eIF-4 gamma
UniProtKB/Swiss-Prot: CWC22_HUMAN, Q9HCG8Similarity: Belongs to the CWC22 familySimilarity: Contains 1 MI domainSimilarity: Contains 1 MIF4G domain |
Function
for CWC22 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CWC22_HUMAN, Q9HCG8Function: May be involved in pre-mRNA splicing
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CWC22 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CWC22
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CWC22 (NM_020943) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CWC22 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CWC22 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CWC22 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
CWC22 for ontologies About GeneDecksing
7 GenomeRNAi human phenotypes for CWC22:
|
Pathways & Interactions
for CWC22 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CWC22
STRING Interaction
Network Preview (showing 5 interactants - click image to see 22)
5/72 Interacting proteins for CWC22 (Q9HCG82, 3 ENSP000003870064) via UniProtKB, MINT, STRING, and/or I2D (see all 72)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
CWC22 for ontologies About GeneDecksing
|
Drugs & Compounds
for CWC22 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CWC22
Search CenterWatch for drugs/clinical trials and news about CWC22
|
Transcripts
for CWC22 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CWC22 gene: NM_020943.2 Unigene Cluster for CWC22: CWC22 spliceosome-associated protein homolog (S. cerevisiae) Hs.311363 [show with all ESTs]Unigene Representative Sequence: NM_0209433 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000410053(uc002uno.2 uc010frh.1 uc002unp.2) ENST00000404136
ENST00000295749
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CWC22 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CWC22
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CWC22 (NM_020943) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CWC22 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CWC22 |
Additional cDNA sequence: AB046824.1 AK025635.1 AK026978.1 AK123647.1 BC016651.1 BC031216.1 BC041662.1 BC053573.1 BC057826.1 BC093952.1 BC093954.1 BC143433.1 10 DOTS entries: DT.211201 DT.99983334 DT.101975253 DT.120931954 DT.95250819 DT.100773709 DT.101966534 DT.120931886 DT.120931967 DT.75148834 24/105 AceView cDNA sequences (see all 105): BC057826 AW512450 BU676271 BI789261 BU182838 CK821194 AW069200 AI624885 AA236786 AI753518 AI925345 BI962595 BI789127 AA293258 AV716187 CK821193 AI580093 BQ435052 CR616945 BE464084 BI962772 AA713496 BC016651 BU165349
GeneLoc Exon Structure
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Expression
for CWC22 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CWC22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CWC22 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CWC22
SOURCE GeneReport for Unigene cluster: Hs.311363
SABiosciences Custom PCR Arrays for CWC22
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CWC22
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CWC22 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CWC22 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CWC22 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CWC22 |
Orthologs
for CWC22 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CWC22 gene from 10/38 species (see all 38) About this table
ENSEMBL Gene Tree for CWC22 (if available)
TreeFam Gene Tree for CWC22 (if available) |
Paralogs
for CWC22 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CWC22 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CWC22 (180809603 - 180871840 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CWC22: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CWC22 |
|
Disorders
/ Diseases
for CWC22 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CWC22 for disorders About GeneDecksing
4  diseases for CWC22: About MalaCardsnevus cerebral malaria cerebritis malaria
Human Genome Epidemiology (HuGE) Navigator: CWC22 (1 document)
Export disorders for CWC22 gene to outside databases
|
Publications
for CWC22 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CWC22 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with CWC22) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (2002)
- Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (2000)
- Distinct requirements for somatic and germline expression of a generally expressed Caernorhabditis elegans gene. (PubMed id 9136012)1, 3 Kelly W.G....Fire A. (1997)
- Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (2012)
- A genome-wide search for loci interacting with known p rostate cancer risk-associated genetic variants. (PubMed id 22219177)1 Tao S....Sun J. (2012)
- Human spliceosomal protein CWC22 plays a role in coupl ing splicing to exon junction complex deposition and nonsense-mediated decay. (PubMed id 23236153)1 Alexandrov A....Steitz J.A. (2012)
- Human CWC22 escorts the helicase eIF4AIII to spliceoso mes and promotes exon junction complex assembly. (PubMed id 22961380)1 Barbosa I....Le Hir H. (2012)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
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External Searches for CWC22 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CWC22 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CWC22 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing CWC22 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CWC22 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CWC22 gene:
Search GeneIP for patents involving CWC22
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CWC22 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | Browse OriGene 29mer shRNA kits in GFP-retroviral vector | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CWC22 | | | OriGene Protein Over-expression Lysate for CWC22 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for CWC22 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CWC22 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CWC22 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CWC22 | | OriGene Custom Protein Services for CWC22 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CWC22 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CWC22 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CWC22 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CWC22 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CWC22 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CWC22 |
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| | | | Search Tocris compounds for CWC22 |
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 | | | CWC22 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CWC22 |
|  |  |  | | | | ThermoFisher Antibody for CWC22 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CWC22 |
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