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Aliases for CWC22 Gene

Aliases for CWC22 Gene

  • CWC22 Spliceosome-Associated Protein 2 3
  • NCM 3 4 6
  • Functional Spliceosome-Associated Protein B 2 3
  • Nucampholin Homolog 3 4
  • KIAA1604 4 6
  • FSAPb 3 4
  • CWC22 Spliceosome-Associated Protein Homolog (S. Cerevisiae) 2
  • CWC22 Spliceosome-Associated Protein Homolog 3
  • Pre-MRNA-Splicing Factor CWC22 Homolog 3
  • EIF4GL 3
  • Cwc2 6

External Ids for CWC22 Gene

Summaries for CWC22 Gene

GeneCards Summary for CWC22 Gene

CWC22 (CWC22 Spliceosome-Associated Protein) is a Protein Coding gene. Diseases associated with CWC22 include malaria. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for CWC22 Gene

  • Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CWC22 Gene

Genomics for CWC22 Gene

Genomic Location for CWC22 Gene

Start:
179,944,876 bp from pter
End:
180,007,297 bp from pter
Size:
62,422 bases
Orientation:
Minus strand

Genomic View for CWC22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CWC22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CWC22 Gene

Regulatory Elements for CWC22 Gene

Proteins for CWC22 Gene

  • Protein details for CWC22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCG8-CWC22_HUMAN
    Recommended name:
    Pre-mRNA-splicing factor CWC22 homolog
    Protein Accession:
    Q9HCG8
    Secondary Accessions:
    • Q05DC2
    • Q4G135
    • Q52LF0
    • Q6PEX2
    • Q7Z6I0
    • Q9H5L3
    • Q9H6Q6

    Protein attributes for CWC22 Gene

    Size:
    908 amino acids
    Molecular mass:
    105466 Da
    Quaternary structure:
    • Component of the spliceosome C complex. Interacts with EIF4A3 and PRPF19 in an RNA-independent manner. Direct interaction with EIF4A3 is mediated by the MIF4G domain. Full interaction with EIF4A3 occurs only when EIF4A3 is not part of the EJC and prevents EIF4A3 binding to RNA.
    SequenceCaution:
    • Sequence=AAH16651.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH31216.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH57826.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB13430.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB15197.1; Type=Frameshift; Positions=555; Evidence={ECO:0000305}; Sequence=BAB15612.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CWC22 Gene

neXtProt entry for CWC22 Gene

Proteomics data for CWC22 Gene at MOPED

Post-translational modifications for CWC22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CWC22 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CWC22 Gene

Domains for CWC22 Gene

UniProtKB/Swiss-Prot:

CWC22_HUMAN
Domain:
  • Contains 1 MI domain.:
    • Q9HCG8
  • Contains 1 MIF4G domain.:
    • Q9HCG8
Family:
  • Belongs to the CWC22 family.:
    • Q9HCG8
genes like me logo Genes that share domains with CWC22: view

No data available for Gene Families for CWC22 Gene

Function for CWC22 Gene

Molecular function for CWC22 Gene

UniProtKB/Swiss-Prot Function: Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay.

Gene Ontology (GO) - Molecular Function for CWC22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 11991638
GO:0005488 binding --
GO:0005515 protein binding IPI 22365833
genes like me logo Genes that share ontologies with CWC22: view
genes like me logo Genes that share phenotypes with CWC22: view

miRNA for CWC22 Gene

miRTarBase miRNAs that target CWC22

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CWC22 Gene

Localization for CWC22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CWC22 Gene

Nucleus. Nucleus speckle. Note=Concentrates around speckles, which are sites of pre-mRNA synthesis and processing, where it colocalizes with EJC core proteins.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CWC22 Gene COMPARTMENTS Subcellular localization image for CWC22 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for CWC22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005681 spliceosomal complex IDA 11991638
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with CWC22: view

Pathways for CWC22 Gene

SuperPathways for CWC22 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CWC22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0048024 regulation of mRNA splicing, via spliceosome IC 11991638
genes like me logo Genes that share ontologies with CWC22: view

No data available for Pathways by source for CWC22 Gene

Transcripts for CWC22 Gene

mRNA/cDNA for CWC22 Gene

Unigene Clusters for CWC22 Gene

CWC22 spliceosome-associated protein homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CWC22 Gene

No ASD Table

Relevant External Links for CWC22 Gene

GeneLoc Exon Structure for
CWC22
ECgene alternative splicing isoforms for
CWC22

Expression for CWC22 Gene

mRNA expression in normal human tissues for CWC22 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CWC22 Gene

SOURCE GeneReport for Unigene cluster for CWC22 Gene Hs.311363

genes like me logo Genes that share expressions with CWC22: view

Orthologs for CWC22 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CWC22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CWC22 36
  • 99.49 (n)
  • 99.45 (a)
CWC22 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CWC22 36
  • 90.03 (n)
  • 91.43 (a)
CWC22 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CWC22 36
  • 92.25 (n)
  • 93.38 (a)
CWC22 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cwc22 36
  • 81.37 (n)
  • 83.22 (a)
Cwc22 16
Cwc22 37
  • 84 (a)
OneToMany
Gm13691 37
  • 85 (a)
OneToMany
Gm13693 37
  • 85 (a)
OneToMany
Gm13694 37
  • 85 (a)
OneToMany
Gm13695 37
  • 85 (a)
OneToMany
Gm13696 37
  • 85 (a)
OneToMany
Gm13697 37
  • 85 (a)
OneToMany
Gm13698 37
  • 85 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 86 (a)
OneToMany
-- 37
  • 86 (a)
OneToMany
-- 37
  • 82 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CWC22 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cwc22 36
  • 81.32 (n)
  • 83.57 (a)
chicken
(Gallus gallus)
Aves CWC22 36
  • 73 (n)
  • 75.19 (a)
CWC22 37
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CWC22 37
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14416 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cwc22 36
  • 70.1 (n)
  • 77.14 (a)
Str.1664 36
zebrafish
(Danio rerio)
Actinopterygii cwc22 36
  • 64.12 (n)
  • 70.15 (a)
cwc22 37
  • 58 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007874 36
  • 61.9 (n)
  • 66.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta ncm 37
  • 35 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea let-858 37
  • 42 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL355W 36
  • 43 (n)
  • 32.62 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CWC22 36
  • 46.33 (n)
  • 32.84 (a)
CWC22 37
  • 29 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C14025g 36
  • 43.07 (n)
  • 28.57 (a)
soybean
(Glycine max)
eudicotyledons Gma.8911 36
rice
(Oryza sativa)
Liliopsida Os.21031 36
wheat
(Triticum aestivum)
Liliopsida Ta.28538 36
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cwf22 36
  • 59.1 (n)
  • 55.53 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7815 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10626 37
  • 53 (a)
OneToOne
Species with no ortholog for CWC22:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CWC22 Gene

ENSEMBL:
Gene Tree for CWC22 (if available)
TreeFam:
Gene Tree for CWC22 (if available)

Paralogs for CWC22 Gene

No data available for Paralogs for CWC22 Gene

Variants for CWC22 Gene

Sequence variations from dbSNP and Humsavar for CWC22 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs166379 -- 180,004,111(-) ATCCC(G/T)CTTAT intron-variant
rs262277 -- 180,004,893(-) CCAAA(A/G)TACTT intron-variant
rs262278 -- 180,004,461(-) TGAGC(C/T)GAGCT intron-variant
rs262279 -- 180,004,418(-) TGAGC(C/T)TCTGT intron-variant
rs262280 -- 180,002,695(-) CCCAA(A/G)CCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CWC22 Gene

Variant ID Type Subtype PubMed ID
dgv4376n71 CNV Gain 21882294
nsv521134 CNV Gain 19592680
nsv834473 CNV Gain 17160897

Relevant External Links for CWC22 Gene

HapMap Linkage Disequilibrium report
CWC22

Disorders for CWC22 Gene

(1) MalaCards Diseases for CWC22 Gene

Search for CWC22 Gene in MalaCards »

Relevant External Links for CWC22

Genetic Association Database (GAD)
CWC22
Human Genome Epidemiology (HuGE) Navigator
CWC22
genes like me logo Genes that share disorders with CWC22: view

No data available for UniProtKB/Swiss-Prot for CWC22 Gene

Publications for CWC22 Gene

  1. Human spliceosomal protein CWC22 plays a role in coupling splicing to exon junction complex deposition and nonsense-mediated decay. (PMID: 23236153) Alexandrov A. … Steitz J.A. (Proc. Natl. Acad. Sci. U.S.A. 2012) 2 3 4
  2. Distinct requirements for somatic and germline expression of a generally expressed Caernorhabditis elegans gene. (PMID: 9136012) Kelly W.G. … Fire A. (Genetics 1997) 2 3
  3. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica M.S. … Moore M.J. (RNA 2002) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CWC22 Gene

Sources for CWC22 Gene

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