CWC15 Gene
protein-coding GIFtS: 47
GCID: GC11M094695
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CWC15 spliceosome-associated protein homolog (S. cerevisiae)(Previous name: CWC15 homolog (S. cerevisiae) )
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Aliases
for CWC15 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CWC15 Spliceosome-Associated Protein Homolog (S. Cerevisiae)1 2 | | ORF52 | | C11orf51 2 3 | | CWC15 Homolog2 | | Cwf151 2 | | Protein CWC15 Homolog2 | | HSPC1481 2 | | Spliceosome-Associated Protein CWC15 Homolog2 | | CWC15 Homolog (S. Cerevisiae)1 | | |
Export aliases for CWC15 gene to outside databasesPrevious GC identifers: GC11M094337 GC11M090760 |
Summaries
for CWC15 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CWC15_HUMAN, Q9P013Function: Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required foractivating pre-mRNA splicing
Gene Wiki entry for CWC15
|
Genomic Views
for CWC15 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CWC15 gene promoter:
Sp1 AP-1 RREB-1 Nkx2-2 ATF-2 c-Jun En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CWC15
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CWC15 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q21 Ensembl cytogenetic band: 11q21 HGNC cytogenetic band: 11q21CWC15 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M094695: view genomic region
(about GC identifiers)
Start:
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94,695,787 bp from pter |
End:
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94,706,776 bp from pter |
Size:
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10,990 bases |
Orientation:
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minus strand |
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Proteins
for CWC15 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CWC15_HUMAN, Q9P013 (See
protein sequence)Recommended Name: Spliceosome-associated protein CWC15 homolog Size: 229 amino acids; 26624 Da
Subunit: Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19,CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interactsdirectly with CTNNBL1 in the complex
Subcellular location: Nucleus
Caution: Has been termed C11orf5 (PubMed:10873569), but is not the official C11orf5 as defined by HGNC
Secondary accessions: B2RC17 Q05BV9 Q05DM1 Q9UI29Explore the universe of human proteins at neXtProt for CWC15: NX_Q9P013
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9P013
CWC15 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057487.2
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
CWC15 for ontologies About GeneDecksing
CWC15 Antibody Products:
Assay Products for CWC15: |
Protein
Domains /
Families
for CWC15 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CWC15 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9P013ProtoNet protein and cluster: Q9P013 UniProtKB/Swiss-Prot: CWC15_HUMAN, Q9P013Similarity: Belongs to the CWC15 family |
Function
for CWC15 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CWC15_HUMAN, Q9P013Function: Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required foractivating pre-mRNA splicing
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CWC15 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CWC15
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: CWC15 (NM_016403) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CWC15 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CWC15 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CWC15 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
CWC15 for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for CWC15:
|
Pathways & Interactions
for CWC15 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | mRNA Splicing - Major Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for CWC15):
CWC15 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CWC15
5/534 Interacting proteins for CWC15 (Q9P0132, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 534)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000398 | mRNA splicing, via spliceosome |
ISS | -- |
CWC15 for ontologies About GeneDecksing
|
Drugs & Compounds
for CWC15 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CWC15
Search CenterWatch for drugs/clinical trials and news about CWC15
|
Transcripts
for CWC15 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CWC15 gene: NM_016403.3 Unigene Cluster for CWC15: CWC15 spliceosome-associated protein homolog (S. cerevisiae) Hs.503597 [show with all ESTs]Unigene Representative Sequence: NM_0164037 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000545018(uc001pfd.4) ENST00000540722 ENST00000545971 ENST00000539856
ENST00000542907 ENST00000542165(uc009ywl.1) ENST00000279839
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CWC15 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CWC15
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CWC15 (NM_016403) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CWC15 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CWC15 |
Additional cDNA sequence: AF110775.1 AF161497.1 AJ250393.1 AK225956.1 AK309042.1 AK314900.1 BC006975.1 BC032629.1 BC040946.1 13 DOTS entries: DT.454142 DT.95171884 DT.40118341 DT.92437513 DT.91830371 DT.120703023 DT.95171889 DT.120703007 DT.92437507 DT.92437512 DT.95171888 DT.40251378 DT.95337994 24/341 AceView cDNA sequences (see all 341): AI969806 AA747825 AA383032 CR596277 AA565864 CB114187 CR599874 AL543596 AA293627 W73840 BM848927 AA446267 BP377818 CA391831 W72164 BM702793 AA431145 AI024076 AA188871 BC006975 AA459134 AA382428 CA389294 BM781869
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for CWC15 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CWC15
|
Expression
for CWC15 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CWC15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CWC15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CWC15
SOURCE GeneReport for Unigene cluster: Hs.503597
SABiosciences Custom PCR Arrays for CWC15
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CWC15
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CWC15 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CWC15 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CWC15 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CWC15 |
Orthologs
for CWC15 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CWC15 gene from 8/21 species (see all 21) About this table
ENSEMBL Gene Tree for CWC15 (if available)
TreeFam Gene Tree for CWC15 (if available) |
Paralogs
for CWC15 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CWC15 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CWC15 (94695787 - 94706776 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CWC15: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for CWC15 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CWC15 for disorders About GeneDecksing
7  diseases for CWC15: About MalaCardsherpes zoster inclusion conjunctivitis laryngotracheitis chickenpox
conduct disorder adhd conjunctivitis
3 diseases from the University of Copenhagen DISEASES database for CWC15:Laryngotracheitis Herpes zoster Chickenpox Export disorders for CWC15 gene to outside databases
|
Publications
for CWC15 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CWC15 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with CWC15) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of five novel human genes in the 11q13-q22 region. (PubMed id 10873569)1, 2, 3 O'Brien K.P....Dumanski J.P. (2000)
- Molecular architecture of the human Prp19/CDC5L compl ex. (PubMed id 20176811)1, 2 Grote M....LA1hrmann R. (2010)
- Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs. (PubMed id 11884590)1, 3 Ohi M.D....Gould K.L. (2002)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Protein microarray analysis identifies human cellular prion protein interactors. (PubMed id 18482256)1 Satoh J....Tabunoki H. (2009)
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External Searches for CWC15 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CWC15 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CWC15 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CWC15 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CWC15 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CWC15 gene:
Search GeneIP for patents involving CWC15
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CWC15 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CWC15 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CWC15 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CWC15 | | | OriGene Protein Over-expression Lysate for CWC15 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CWC15 | | OriGene 3'-UTR Clone for CWC15 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CWC15 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CWC15 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CWC15 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CWC15 | | OriGene Custom Protein Services for CWC15 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CWC15 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CWC15 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CWC15 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CWC15 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CWC15 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CWC15 |
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| | | | Search Tocris compounds for CWC15 |
| |  |  |  |  | | | | |
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 | | | CWC15 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CWC15 |
|  |  |  | | | | ThermoFisher Antibodies for CWC15 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CWC15 |
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