Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CWC15 Gene

Aliases for CWC15 Gene

  • CWC15 Spliceosome-Associated Protein 2 3
  • C11orf5 3 4
  • CWC15 Spliceosome-Associated Protein Homolog (S. Cerevisiae) 2
  • CWC15 Spliceosome-Associated Protein Homolog 3
  • Spliceosome-Associated Protein CWC15 Homolog 3
  • CWC15 Homolog (S. Cerevisiae) 2
  • HSPC148 3
  • AD002 3
  • Cwf15 3
  • ORF5 3

External Ids for CWC15 Gene

Previous GeneCards Identifiers for CWC15 Gene

  • GC11M094337
  • GC11M094695
  • GC11M090760

Summaries for CWC15 Gene

GeneCards Summary for CWC15 Gene

CWC15 (CWC15 Spliceosome-Associated Protein) is a Protein Coding gene. Diseases associated with CWC15 include laryngotracheitis. Among its related pathways are Spliceosome. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for CWC15 Gene

  • Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.

Gene Wiki entry for CWC15 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CWC15 Gene

Genomics for CWC15 Gene

Regulatory Elements for CWC15 Gene

Genomic Location for CWC15 Gene

Start:
94,962,622 bp from pter
End:
94,973,612 bp from pter
Size:
10,991 bases
Orientation:
Minus strand

Genomic View for CWC15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CWC15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CWC15 Gene

Proteins for CWC15 Gene

  • Protein details for CWC15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P013-CWC15_HUMAN
    Recommended name:
    Spliceosome-associated protein CWC15 homolog
    Protein Accession:
    Q9P013
    Secondary Accessions:
    • B2RC17
    • Q05BV9
    • Q05DM1
    • Q9UI29

    Protein attributes for CWC15 Gene

    Size:
    229 amino acids
    Molecular mass:
    26624 Da
    Quaternary structure:
    • Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly with CTNNBL1 in the complex.

neXtProt entry for CWC15 Gene

Proteomics data for CWC15 Gene at MOPED

Post-translational modifications for CWC15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CWC15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CWC15 Gene

Domains for CWC15 Gene

Protein Domains for CWC15 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CWC15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P013

UniProtKB/Swiss-Prot:

CWC15_HUMAN :
  • Q9P013
Family:
  • Belongs to the CWC15 family.
genes like me logo Genes that share domains with CWC15: view

No data available for Gene Families for CWC15 Gene

Function for CWC15 Gene

Molecular function for CWC15 Gene

UniProtKB/Swiss-Prot Function: Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.

Gene Ontology (GO) - Molecular Function for CWC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding ISS --
GO:0005515 protein binding IPI 20176811
genes like me logo Genes that share ontologies with CWC15: view
genes like me logo Genes that share phenotypes with CWC15: view

Animal Model Products

CRISPR Products

miRNA for CWC15 Gene

miRTarBase miRNAs that target CWC15

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CWC15 Gene

Localization for CWC15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CWC15 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CWC15 Gene COMPARTMENTS Subcellular localization image for CWC15 gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for CWC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20176811
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IDA 20176811
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with CWC15: view

Pathways for CWC15 Gene

SuperPathways for CWC15 Gene

Superpath Contained pathways
1 Spliceosome
genes like me logo Genes that share pathways with CWC15: view

Pathways by source for CWC15 Gene

1 KEGG pathway for CWC15 Gene

Interacting Proteins for CWC15 Gene

Gene Ontology (GO) - Biological Process for CWC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0008380 RNA splicing TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with CWC15: view

Transcripts for CWC15 Gene

Unigene Clusters for CWC15 Gene

CWC15 spliceosome-associated protein homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CWC15

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CWC15 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2: - - -
SP3: - -
SP4: -
SP5:

Relevant External Links for CWC15 Gene

GeneLoc Exon Structure for
CWC15
ECgene alternative splicing isoforms for
CWC15

Expression for CWC15 Gene

mRNA expression in normal human tissues for CWC15 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CWC15 Gene

SOURCE GeneReport for Unigene cluster for CWC15 Gene Hs.503597

genes like me logo Genes that share expressions with CWC15: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CWC15 Gene

Orthologs for CWC15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CWC15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CWC15 35
  • 99.71 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia CWC15 35
  • 91.99 (n)
  • 96.94 (a)
CWC15 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 96 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
CWC15 35
  • 91.7 (n)
  • 96.94 (a)
mouse
(Mus musculus)
Mammalia Cwc15 35
  • 90.54 (n)
  • 99.13 (a)
Cwc15 16
Cwc15 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cwc15 35
  • 90.54 (n)
  • 99.56 (a)
chicken
(Gallus gallus)
Aves CWC15 35
  • 82.97 (n)
  • 95.63 (a)
CWC15 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CWC15 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cwc15 35
  • 76.95 (n)
  • 90.75 (a)
Str.6431 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4317 35
zebrafish
(Danio rerio)
Actinopterygii CWC15 36
  • 79 (a)
OneToOne
wufj68d08 35
zgc:86607 35
  • 74.3 (n)
  • 85.02 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010594 35
  • 58.22 (n)
  • 63.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta c12.1 35
  • 56.43 (n)
  • 62.33 (a)
c12.1 36
  • 53 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_T10C6.5 35
  • 61.04 (n)
  • 64.44 (a)
T10C6.5 36
  • 59 (a)
OneToOne
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7824 35
soybean
(Glycine max)
eudicotyledons Gma.2337 35
thale cress
(Arabidopsis thaliana)
eudicotyledons EMB2769 35
  • 54.39 (n)
  • 49.09 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.6306 35
rice
(Oryza sativa)
Liliopsida Os06g0106100 35
  • 55.01 (n)
  • 49.78 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3383 36
  • 61 (a)
OneToOne
Species with no ortholog for CWC15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CWC15 Gene

ENSEMBL:
Gene Tree for CWC15 (if available)
TreeFam:
Gene Tree for CWC15 (if available)

Paralogs for CWC15 Gene

No data available for Paralogs for CWC15 Gene

Variants for CWC15 Gene

Sequence variations from dbSNP and Humsavar for CWC15 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1039751 -- 94,962,268(+) GCTCT(A/C)CACCG downstream-variant-500B
rs2171184 -- 94,962,327(+) AACTT(C/T)CCATT downstream-variant-500B
rs3737505 -- 94,970,873(-) GTTTA(C/G)TTACT intron-variant
rs3831469 -- 94,971,525(+) TGTGT(-/AC/ACAC/GT/GTGT)TTAAG intron-variant
rs4753645 -- 94,970,928(+) TAGAA(A/T)AGCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CWC15 Gene

Variant ID Type Subtype PubMed ID
nsv446 CNV Loss 18451855

Relevant External Links for CWC15 Gene

HapMap Linkage Disequilibrium report
CWC15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CWC15 Gene

Disorders for CWC15 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CWC15 Gene including...

Search for CWC15 Gene in MalaCards »

(2) University of Copenhagen DISEASES for CWC15 Gene

Relevant External Links for CWC15

Genetic Association Database (GAD)
CWC15
genes like me logo Genes that share disorders with CWC15: view

No data available for UniProtKB/Swiss-Prot for CWC15 Gene

Publications for CWC15 Gene

  1. Characterization of five novel human genes in the 11q13-q22 region. (PMID: 10873569) O'Brien K.P. … Dumanski J.P. (Biochem. Biophys. Res. Commun. 2000) 2 3 4
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  3. Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs. (PMID: 11884590) Ohi M.D. … Gould K.L. (Mol. Cell. Biol. 2002) 2 3
  4. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney R.J. … Gill M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 48
  5. Molecular architecture of the human Prp19/CDC5L complex. (PMID: 20176811) Grote M. … Luhrmann R. (Mol. Cell. Biol. 2010) 3 4

Products for CWC15 Gene

Sources for CWC15 Gene

Back to Top

Content