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Aliases for CWC15 Gene

Aliases for CWC15 Gene

  • CWC15 Spliceosome-Associated Protein 2 3 5
  • C11orf5 3 4
  • CWC15 Spliceosome-Associated Protein Homolog (S. Cerevisiae) 2
  • CWC15 Spliceosome-Associated Protein Homolog 3
  • CWC15 Homolog (S. Cerevisiae) 2
  • HSPC148 3
  • AD002 3
  • Cwf15 3
  • ORF5 3

External Ids for CWC15 Gene

Previous GeneCards Identifiers for CWC15 Gene

  • GC11M094337
  • GC11M094695
  • GC11M090760

Summaries for CWC15 Gene

GeneCards Summary for CWC15 Gene

CWC15 (CWC15 Spliceosome-Associated Protein) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for CWC15 Gene

  • Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.

Gene Wiki entry for CWC15 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CWC15 Gene

Genomics for CWC15 Gene

Regulatory Elements for CWC15 Gene

Promoters for CWC15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CWC15 on UCSC Golden Path with GeneCards custom track

Genomic Location for CWC15 Gene

Chromosome:
11
Start:
94,962,622 bp from pter
End:
94,973,612 bp from pter
Size:
10,991 bases
Orientation:
Minus strand

Genomic View for CWC15 Gene

Genes around CWC15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CWC15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CWC15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CWC15 Gene

Proteins for CWC15 Gene

  • Protein details for CWC15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P013-CWC15_HUMAN
    Recommended name:
    Spliceosome-associated protein CWC15 homolog
    Protein Accession:
    Q9P013
    Secondary Accessions:
    • B2RC17
    • Q05BV9
    • Q05DM1
    • Q9UI29

    Protein attributes for CWC15 Gene

    Size:
    229 amino acids
    Molecular mass:
    26624 Da
    Quaternary structure:
    • Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly with CTNNBL1 in the complex.

neXtProt entry for CWC15 Gene

Proteomics data for CWC15 Gene at MOPED

Post-translational modifications for CWC15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CWC15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CWC15 Gene

Domains & Families for CWC15 Gene

Protein Domains for CWC15 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CWC15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P013

UniProtKB/Swiss-Prot:

CWC15_HUMAN :
  • Belongs to the CWC15 family.
Family:
  • Belongs to the CWC15 family.
genes like me logo Genes that share domains with CWC15: view

No data available for Gene Families for CWC15 Gene

Function for CWC15 Gene

Molecular function for CWC15 Gene

UniProtKB/Swiss-Prot Function:
Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.
genes like me logo Genes that share phenotypes with CWC15: view

Animal Model Products

CRISPR Products

miRNA for CWC15 Gene

miRTarBase miRNAs that target CWC15

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CWC15 Gene

Localization for CWC15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CWC15 Gene

Gene Ontology (GO) - Cellular Components for CWC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CWC15: view

No data available for Subcellular locations from COMPARTMENTS for CWC15 Gene

Pathways & Interactions for CWC15 Gene

genes like me logo Genes that share pathways with CWC15: view

Pathways by source for CWC15 Gene

Interacting Proteins for CWC15 Gene

Gene Ontology (GO) - Biological Process for CWC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
genes like me logo Genes that share ontologies with CWC15: view

No data available for SIGNOR curated interactions for CWC15 Gene

Drugs & Compounds for CWC15 Gene

No Compound Related Data Available

Transcripts for CWC15 Gene

Unigene Clusters for CWC15 Gene

CWC15 spliceosome-associated protein homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CWC15 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2: - - -
SP3: - -
SP4: -
SP5:

Relevant External Links for CWC15 Gene

GeneLoc Exon Structure for
CWC15
ECgene alternative splicing isoforms for
CWC15

Expression for CWC15 Gene

mRNA expression in normal human tissues for CWC15 Gene

Protein differential expression in normal tissues from HIPED for CWC15 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.8), Breast (9.7), NK cells (6.6), and Lymph node (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CWC15 Gene



SOURCE GeneReport for Unigene cluster for CWC15 Gene Hs.503597

genes like me logo Genes that share expression patterns with CWC15: view

Protein tissue co-expression partners for CWC15 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CWC15 Gene

Orthologs for CWC15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CWC15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CWC15 35
  • 91.99 (n)
  • 96.94 (a)
CWC15 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CWC15 35
  • 91.7 (n)
  • 96.94 (a)
-- 36
  • 96 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cwc15 35
  • 90.54 (n)
  • 99.13 (a)
Cwc15 16
Cwc15 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CWC15 35
  • 99.71 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Cwc15 35
  • 90.54 (n)
  • 99.56 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
chicken
(Gallus gallus)
Aves CWC15 35
  • 82.97 (n)
  • 95.63 (a)
CWC15 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CWC15 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cwc15 35
  • 76.95 (n)
  • 90.75 (a)
Str.6431 35
zebrafish
(Danio rerio)
Actinopterygii wufj68d08 35
zgc:86607 35
  • 74.3 (n)
  • 85.02 (a)
CWC15 36
  • 79 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4317 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010594 35
  • 58.22 (n)
  • 63.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta c12.1 35
  • 56.43 (n)
  • 62.33 (a)
c12.1 36
  • 53 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_T10C6.5 35
  • 61.04 (n)
  • 64.44 (a)
T10C6.5 36
  • 59 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons EMB2769 35
  • 54.39 (n)
  • 49.09 (a)
soybean
(Glycine max)
eudicotyledons Gma.2337 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7824 35
barley
(Hordeum vulgare)
Liliopsida Hv.6306 35
rice
(Oryza sativa)
Liliopsida Os06g0106100 35
  • 55.01 (n)
  • 49.78 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3383 36
  • 61 (a)
OneToOne
Species with no ortholog for CWC15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CWC15 Gene

ENSEMBL:
Gene Tree for CWC15 (if available)
TreeFam:
Gene Tree for CWC15 (if available)

Paralogs for CWC15 Gene

No data available for Paralogs for CWC15 Gene

Variants for CWC15 Gene

Sequence variations from dbSNP and Humsavar for CWC15 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1039751 -- 94,962,268(+) GCTCT(A/C)CACCG downstream-variant-500B
rs2171184 -- 94,962,327(+) AACTT(C/T)CCATT downstream-variant-500B
rs3737505 -- 94,970,873(-) GTTTA(C/G)TTACT intron-variant
rs3831469 -- 94,971,525(+) TGTGT(-/AC/ACAC/ACACAC/C/GT/GTGT)TTAAG intron-variant
rs6483382 -- 94,970,400(+) GATAT(C/T)ACTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CWC15 Gene

Variant ID Type Subtype PubMed ID
nsv446 CNV Loss 18451855

Variation tolerance for CWC15 Gene

Gene Damage Index Score: 0.10; 2.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CWC15 Gene

HapMap Linkage Disequilibrium report
CWC15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CWC15 Gene

Disorders for CWC15 Gene

Relevant External Links for CWC15

Genetic Association Database (GAD)
CWC15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CWC15

No disorders were found for CWC15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CWC15 Gene

Publications for CWC15 Gene

  1. Characterization of five novel human genes in the 11q13-q22 region. (PMID: 10873569) O'Brien K.P. … Dumanski J.P. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 67
  2. Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs. (PMID: 11884590) Ohi M.D. … Gould K.L. (Mol. Cell. Biol. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Dynamic protein-protein interaction wiring of the human spliceosome. (PMID: 22365833) Hegele A. … Stelzl U. (Mol. Cell 2012) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for CWC15 Gene

Sources for CWC15 Gene

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