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Aliases for CUZD1 Gene

Aliases for CUZD1 Gene

  • CUB And Zona Pellucida-Like Domains 1 2 3
  • CUB And ZP Domain-Containing Protein 1 3 4
  • Transmembrane Protein UO-44 3 4
  • CUB And Zona Pellucida-Like Domain-Containing Protein 1 3
  • Estrogen Regulated Gene 1 3
  • ERG-1 3
  • UO-44 3

External Ids for CUZD1 Gene

Previous GeneCards Identifiers for CUZD1 Gene

  • GC10M124132
  • GC10M124582
  • GC10M118209

Summaries for CUZD1 Gene

GeneCards Summary for CUZD1 Gene

CUZD1 (CUB And Zona Pellucida-Like Domains 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CUZD1 Gene

  • CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes. May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic acinar cells.

Gene Wiki entry for CUZD1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUZD1 Gene

Genomics for CUZD1 Gene

Regulatory Elements for CUZD1 Gene

Genomic Location for CUZD1 Gene

Start:
122,832,149 bp from pter
End:
122,850,793 bp from pter
Size:
18,645 bases
Orientation:
Minus strand

Genomic View for CUZD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CUZD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUZD1 Gene

Proteins for CUZD1 Gene

  • Protein details for CUZD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UP6-CUZD1_HUMAN
    Recommended name:
    CUB and zona pellucida-like domain-containing protein 1
    Protein Accession:
    Q86UP6
    Secondary Accessions:
    • A8K080
    • B2RN93
    • D3DRE5
    • Q7Z660
    • Q7Z661
    • Q86SG1
    • Q86UP5
    • Q9HAR7

    Protein attributes for CUZD1 Gene

    Size:
    607 amino acids
    Molecular mass:
    68153 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG23215.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for CUZD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CUZD1 Gene

Proteomics data for CUZD1 Gene at MOPED

Post-translational modifications for CUZD1 Gene

  • Glycosylation at Asn29, Asn57, Asn67, Asn271, Asn394, and Asn419
  • Modification sites at PhosphoSitePlus

Other Protein References for CUZD1 Gene

No data available for DME Specific Peptides for CUZD1 Gene

Domains for CUZD1 Gene

Protein Domains for CUZD1 Gene

Suggested Antigen Peptide Sequences for CUZD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86UP6

UniProtKB/Swiss-Prot:

CUZD1_HUMAN :
  • Q86UP6
Domain:
  • Contains 2 CUB domains.
  • Contains 1 ZP domain.
genes like me logo Genes that share domains with CUZD1: view

No data available for Gene Families for CUZD1 Gene

Function for CUZD1 Gene

Molecular function for CUZD1 Gene

UniProtKB/Swiss-Prot Function: CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes. May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic acinar cells.

Phenotypes for CUZD1 Gene

genes like me logo Genes that share phenotypes with CUZD1: view

Animal Models for CUZD1 Gene

MGI Knock Outs for CUZD1:

Animal Model Products

CRISPR Products

miRNA for CUZD1 Gene

miRTarBase miRNAs that target CUZD1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CUZD1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targeting and HOMER Transcription for CUZD1 Gene

Localization for CUZD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CUZD1 Gene

Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type I membrane protein. Note=Associated with zymogen granule membranes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CUZD1 Gene COMPARTMENTS Subcellular localization image for CUZD1 gene
Compartment Confidence
plasma membrane 3
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CUZD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane NAS 15184879
GO:0030658 transport vesicle membrane IEA --
GO:0042588 zymogen granule --
GO:0042589 zymogen granule membrane ISS --
genes like me logo Genes that share ontologies with CUZD1: view

Pathways for CUZD1 Gene

SuperPathways for CUZD1 Gene

No Data Available

Interacting Proteins for CUZD1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357900%0d%0a9606.ENSP00000384273%0d%0a9606.ENSP00000391592%0d%0a
Selected Interacting proteins: ENSP00000357900 Q86UP6-CUZD1_HUMAN for CUZD1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CUZD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006931 substrate-dependent cell migration, cell attachment to substrate NAS 15184879
GO:0007049 cell cycle IEA --
GO:0008283 cell proliferation NAS 15184879
GO:0032023 trypsinogen activation ISS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CUZD1: view

No data available for Pathways by source for CUZD1 Gene

Transcripts for CUZD1 Gene

Unigene Clusters for CUZD1 Gene

CUB and zona pellucida-like domains 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CUZD1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CUZD1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CUZD1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - -
SP2: - -
SP3: - - -
SP4: - -
SP5: - - -
SP6: - - - - - - -
SP7: - - - -
SP8: -
SP9:

Relevant External Links for CUZD1 Gene

GeneLoc Exon Structure for
CUZD1
ECgene alternative splicing isoforms for
CUZD1

Expression for CUZD1 Gene

mRNA expression in normal human tissues for CUZD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CUZD1 Gene

This gene is overexpressed in Pancreas (52.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CUZD1 Gene

SOURCE GeneReport for Unigene cluster for CUZD1 Gene Hs.647182

mRNA Expression by UniProt/SwissProt for CUZD1 Gene

Q86UP6-CUZD1_HUMAN
Tissue specificity: Detected in pancreas and epithelium of ovary. Expressed at higher levels in ovarian tumors than in normal tissue.
genes like me logo Genes that share expressions with CUZD1: view

In Situ Assay Products

Orthologs for CUZD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CUZD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CUZD1 35
  • 99.62 (n)
  • 99.34 (a)
CUZD1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CUZD1 35
  • 82.73 (n)
  • 76.9 (a)
CUZD1 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cuzd1 35
  • 77.32 (n)
  • 70.51 (a)
Cuzd1 16
Cuzd1 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CUZD1 36
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CUZD1 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cuzd1 35
  • 77.92 (n)
  • 73.31 (a)
chicken
(Gallus gallus)
Aves CUZD1 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CUZD1 36
  • 33 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485179 35
  • 53.85 (n)
  • 46.39 (a)
zebrafish
(Danio rerio)
Actinopterygii CUZD1 (1 of 5) 36
  • 23 (a)
OneToMany
CUZD1 (2 of 5) 36
  • 17 (a)
OneToMany
CUZD1 (3 of 5) 36
  • 28 (a)
OneToMany
CUZD1 (4 of 5) 36
  • 17 (a)
OneToMany
CUZD1 (5 of 5) 36
  • 23 (a)
OneToMany
LOC555768 35
  • 50.6 (n)
  • 40.67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 13 (a)
OneToOne
Species with no ortholog for CUZD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CUZD1 Gene

ENSEMBL:
Gene Tree for CUZD1 (if available)
TreeFam:
Gene Tree for CUZD1 (if available)

Paralogs for CUZD1 Gene

Selected SIMAP similar genes for CUZD1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CUZD1: view

No data available for Paralogs for CUZD1 Gene

Variants for CUZD1 Gene

Sequence variations from dbSNP and Humsavar for CUZD1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
VAR_061992 -

Structural Variations from Database of Genomic Variants (DGV) for CUZD1 Gene

Variant ID Type Subtype PubMed ID
nsv896064 CNV Loss 21882294
nsv832010 CNV Gain 17160897

Relevant External Links for CUZD1 Gene

HapMap Linkage Disequilibrium report
CUZD1
Human Gene Mutation Database (HGMD)
CUZD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CUZD1 Gene

Disorders for CUZD1 Gene

No disorders were found for CUZD1 Gene.

No data available for UniProtKB/Swiss-Prot for CUZD1 Gene

Publications for CUZD1 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  3. Molecular cloning, characterization and isolation of novel spliced variants of the human ortholog of a rat estrogen-regulated membrane- associated protein, UO-44. (PMID: 15184879) Leong C.T.C. … Huynh H. (Oncogene 2004) 3 4
  4. Silencing expression of UO-44 (CUZD1) using small interfering RNA sensitizes human ovarian cancer cells to cisplatin in vitro. (PMID: 16862170) Leong C.T. … Huynh H. (Oncogene 2007) 3 23
  5. Cloning and uterus/oviduct-specific expression of a novel estrogen-regulated gene (ERG1) (PMID: 10542259) Chen D. … Bagchi I.C. (J. Biol. Chem. 1999) 2 3

Products for CUZD1 Gene

Sources for CUZD1 Gene

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