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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CUZD1 Gene

protein-coding   GIFtS: 47
GCID: GC10M124582

CUB And Zona Pellucida-Like Domains 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
CUB And Zona Pellucida-Like Domains 11 2     UO-442
Transmembrane Protein UO-442 3     CUB And Zona Pellucida-Like Domain-Containing Protein 12
CUB And ZP Domain-Containing Protein 12 3     Estrogen Regulated Gene 12
ERG-12     

External Ids:    HGNC: 179371   Entrez Gene: 506242   Ensembl: ENSG000001381617   UniProtKB: Q86UP63   
ORGUL members:         
NONCODE14:n410665 n410668 n410664      

Export aliases for CUZD1 gene to outside databases

Previous GC identifers: GC10M124132 GC10M118209


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CUZD1 Gene: 
CUZD1 (CUB and zona pellucida-like domains 1) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with CUZD1 include ovarian cancer, and pancreatitis.

UniProtKB/Swiss-Prot: CUZD1_HUMAN, Q86UP6
Function: CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in
these processes. May also play a role in the uterus during late pregnancy and/or in trypsin activation in
pancreatic acinar cells

Gene Wiki entry for CUZD1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CUZD1 gene promoter:
         HOXA9   HOXA9B   C/EBPbeta   Nkx2-5   Cdc5   Meis-1b   Evi-1   MZF-1   AREB6   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CUZD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CUZD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.13   Ensembl cytogenetic band:  10q26.13   HGNC cytogenetic band: 10q26.13

CUZD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CUZD1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M124582:  view genomic region     (about GC identifiers)

Start:
124,591,665 bp from pter      End:
124,639,146 bp from pter
Size:
47,482 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CUZD1

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CUZD1_HUMAN, Q86UP6 (See protein sequence)
Recommended Name: CUB and zona pellucida-like domain-containing protein 1 precursor  
Size: 607 amino acids; 68153 Da
Subcellular location: Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type I membrane protein (By
similarity). Note=Associated with zymogen granule membranes (By similarity)
Sequence caution: Sequence=AAG23215.1; Type=Frameshift; Positions=Several;
Secondary accessions: A8K080 B2RN93 D3DRE5 Q7Z660 Q7Z661 Q86SG1 Q86UP5 Q9HAR7
Alternative splicing: 3 isoforms:  Q86UP6-1   Q86UP6-2   Q86UP6-3   

Explore the universe of human proteins at neXtProt for CUZD1: NX_Q86UP6

Explore proteomics data for CUZD1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86UP6

  • CUZD1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CUZD1 Protein Expression
    REFSEQ proteins: NP_071317.2  
    ENSEMBL proteins: 
     ENSP00000357900   ENSP00000357897   ENSP00000357896   ENSP00000340905   ENSP00000441590  
     ENSP00000376540  

    Human Recombinant Protein Products for CUZD1: 
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    Novus Biologicals CUZD1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CUZD1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane NAS15184879
    GO:0030658transport vesicle membrane IEA--
    GO:0042588zymogen granule ----
    GO:0042589zymogen granule membrane ISS--

    CUZD1 for ontologies           About GeneDecksing



    CUZD1 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR000859 CUB_dom
     IPR001507 ZP_dom

    Graphical View of Domain Structure for InterPro Entry Q86UP6

    ProtoNet protein and cluster: Q86UP6

    2 Blocks protein domains:
    IPB000859 CUB domain
    IPB001507 Endoglin/CD105 antigen


    UniProtKB/Swiss-Prot: CUZD1_HUMAN, Q86UP6
    Similarity: Contains 2 CUB domains
    Similarity: Contains 1 ZP domain


    CUZD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CUZD1_HUMAN, Q86UP6
    Function: CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in
    these processes. May also play a role in the uterus during late pregnancy and/or in trypsin activation in
    pancreatic acinar cells

    Phenotypes:
         1 GenomeRNAi human phenotype for CUZD1:

     Increased G2M DNA content 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cuzd1):
     endocrine/exocrine gland  immune system  mortality/aging 

    CUZD1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cuzd1tm1Ljm for CUZD1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CUZD1 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CUZD1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CUZD1 (Q86UP63 ENSP000003579004) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN6P293503, ENSP000003915924I2D: score=1 STRING: ENSP00000391592
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006931substrate-dependent cell migration, cell attachment to substrate NAS15184879
    GO:0007049cell cycle IEA--
    GO:0008283cell proliferation NAS15184879
    GO:0032023trypsinogen activation ISS--
    GO:0051301cell division IEA--

    CUZD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CUZD1

    Search CenterWatch for drugs/clinical trials and news about CUZD1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CUZD1 gene: 
    NM_022034.5  

    Unigene Cluster for CUZD1:

    CUB and zona pellucida-like domains 1
    Hs.647182  [show with all ESTs]
    Unigene Representative Sequence: NR_037915
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368904(uc009yaf.3 uc001lgr.3 uc010qty.2 uc009yae.3 uc001lgs.3)
    ENST00000368899(uc001lgp.3 uc009yad.3) ENST00000368901 ENST00000368900
    ENST00000338948 ENST00000545804(uc010qtz.2) ENST00000392790
    miRNA
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    Additional mRNA sequence: 

    AF305835.1 AK289445.1 AY260047.1 AY260048.1 AY260049.1 AY260050.1 BC136755.1 BC144398.1 
    BX538283.1 BX538284.1 BX648572.1 NR_037912.1 NR_037915.1 

    4 DOTS entries:

    DT.405801  DT.101978936  DT.100685727  DT.95175918 

    24/65 AceView cDNA sequences (see all 65):

    AY260048 BQ778339 BQ018236 AA417006 AY260047 AA723941 AL703960 BX096610 
    AI378918 AL832386 AA917882 AL832795 BX495744 AY260049 AY260050 AA732367 
    AI005145 BX282650 BG490871 BM047266 AI417638 CD631042 CB410280 BX498017 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CUZD1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                                        -     -                                   -                                             
    SP2:                                                                                      -           -                                             
    SP3:                                                                                      -           -           -                                 
    SP4:                          -     -                                                                                                               
    SP5:                          -     -     -                                                                                                         


    ECgene alternative splicing isoforms for CUZD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CUZD1 expression in normal human tissues (normalized intensities)      CUZD1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCTCCAGG
    CUZD1 Expression
    About this image


    CUZD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Duct Cells Pancreatic Ducts
             Pancreatic Islet   
     
     Intestine (Gastrointestinal Tract)
             duodenum   
     
     Inner Cell Mass (Early Embryonic Tissues)
             Line H9 (WA09)
     
     Lower Urinary Tract (Urinary System)
             bladder   

    See CUZD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CUZD1

    SOURCE GeneReport for Unigene cluster: Hs.647182

    UniProtKB/Swiss-Prot: CUZD1_HUMAN, Q86UP6
    Tissue specificity: Detected in pancreas and epithelium of ovary. Expressed at higher levels in ovarian tumors
    than in normal tissue

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUZD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CUZD1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cuzd11 , 5 CUB and zona pellucida-like domains 11, 5 77.32(n)1
    70.51(a)1
      7 (73.81 cM)5
    164331  NM_008411.31  NP_032437.31 
     1313085555 
    chicken
    (Gallus gallus)
    Aves CUZD16
    CUB and zona pellucida-like domains 1
    56(a)
    1 ↔ 1
    6(30920006-30927511)
    lizard
    (Anolis carolinensis)
    Reptilia CUZD16
    Uncharacterized protein
    20(a)
    1 ↔ 1
    3(59827942-59904198)
    zebrafish
    (Danio rerio)
    Actinopterygii --
    --
    (see all 6)
    --
    37(a)
    36(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    17(21700057-21709731)
    17(21689121-21692297)


    ENSEMBL Gene Tree for CUZD1 (if available)
    TreeFam Gene Tree for CUZD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CUZD1 gene
    1 SIMAP similar gene for CUZD1 using alignment to 1 protein entry:     CUZD1_HUMAN:
    DMBT1

    CUZD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    1 SNPs in CUZD1 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0619924
    ----see VAR_0619922 G S mis40--------

    HapMap Linkage Disequilibrium report for CUZD1 (124591665 - 124639146 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CUZD1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv896064CNV Loss21882294
    nsv832010CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for CUZD1:    About MalaCards
    ovarian cancer    pancreatitis


    CUZD1 for disorders           About GeneDecksing


    Export disorders for CUZD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CUZD1 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with CUZD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    2. Molecular cloning, characterization and isolation of novel spliced variants of the human ortholog of a rat estrogen-regulated membrane- associated protein, UO-44. (PubMed id 15184879)1, 2 Leong C.T.C....Huynh H. (2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. Cloning and uterus/oviduct-specific expression of a novel estrogen-regulated gene (ERG1) (PubMed id 10542259)1, 3 Chen D....Bagchi I.C. (1999)
    5. Silencing expression of UO-44 (CUZD1) using small interfering RNA sensitizes human ovarian cancer cells to cisplatin in vitro. (PubMed id 16862170)1, 9 Leong C.T....Huynh H. (2007)
    6. CUB and zona pellucida-like domain-containing protein 1 (CUZD1): a novel serological biomarker for ovarian cancer. (PubMed id 22985796)1 Leung F....Diamandis E.P. (2012)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    8. Substrate-trapping techniques in the identification of cellular PTP targets. (PubMed id 15588985)1 Blanchetot C....Tremblay M.L. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 50624 HGNC: 17937 AceView: CUZD1 Ensembl:ENSG00000138161 euGenes: HUgn50624
    ECgene: CUZD1 H-InvDB: CUZD1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CUZD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CUZD1 gene:
    Search GeneIP for patents involving CUZD1

    GeneCards and IP:
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