Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CUZD1 Gene

protein-coding   GIFtS: 49
GCID: GC10M124582

CUB and zona pellucida-like domains 1

 Explore 2 diseases affiliated with
CUZD1 via our new
 Human Malady Compendium 
Biological research products
for CUZD1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
CUB And Zona Pellucida-Like Domains 11 2     CUB And ZP Domain-Containing Protein 12 3
ERG-11 2     CUB And Zona Pellucida-Like Domain-Containing Protein 12
UO-441 2     Estrogen Regulated Gene 12
Transmembrane Protein UO-442 3     

External Ids:    HGNC: 179371   Entrez Gene: 506242   Ensembl: ENSG000001381617   UniProtKB: Q86UP63   
ORGUL members:         
NONCODE:n410668 n410665    

Export aliases for CUZD1 gene to outside databases

Previous GC identifers: GC10M124132 GC10M118209


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CUZD1_HUMAN, Q86UP6
Function: CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in
these processes. May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic
acinar cells

Gene Wiki entry for CUZD1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CUZD1 gene promoter:
         HOXA9   HOXA9B   C/EBPbeta   Nkx2-5   Cdc5   Meis-1b   Evi-1   MZF-1   AREB6   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CUZD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CUZD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.13   Ensembl cytogenetic band:  10q26.13   HGNC cytogenetic band: 10q26.13

CUZD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CUZD1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M124582:  view genomic region     (about GC identifiers)

Start:
124,591,665 bp from pter      End:
124,639,146 bp from pter
Size:
47,482 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

  • n410665
  • n410668
124591670 124615414 124639157 chr10

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CUZD1_HUMAN, Q86UP6 (See protein sequence)
Recommended Name: CUB and zona pellucida-like domain-containing protein 1 precursor  
Size: 607 amino acids; 68153 Da
Subcellular location: Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type I membrane protein (By
similarity). Note=Associated with zymogen granule membranes (By similarity)
Sequence caution: Sequence=AAG23215.1; Type=Frameshift; Positions=Several;
Secondary accessions: A8K080 B2RN93 D3DRE5 Q7Z660 Q7Z661 Q86SG1 Q86UP5 Q9HAR7
Alternative splicing: 3 isoforms:  Q86UP6-1   Q86UP6-2   Q86UP6-3   

Explore the universe of human proteins at neXtProt for CUZD1: NX_Q86UP6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86UP6

  • CUZD1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_071317.2  
    ENSEMBL proteins: 
     ENSP00000357900   ENSP00000357897   ENSP00000357896   ENSP00000340905   ENSP00000357895  
     ENSP00000441590   ENSP00000376540  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: CUZD1
    OriGene Custom Protein Services for CUZD1 
    GenScript Custom Purified and Recombinant Proteins Services for CUZD1
    Novus Biologicals CUZD1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CUZD1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane NAS15184879
    GO:0030658transport vesicle membrane IEA--
    GO:0042588zymogen granule ----
    GO:0042589zymogen granule membrane ISS--


    CUZD1 for ontologies           About GeneDecksing



    CUZD1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CUZD1 
    GenScript Custom Superior Antibodies Services for CUZD1
    Novus Biologicals CUZD1 Antibody
    Search for Antibodies for CUZD1 at Abcam  
    Uscn Antibodies for CUZD1
    Search ThermoFisher Antibodies for CUZD1

    Assay Products for CUZD1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CUZD1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CUZD1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CUZD1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000859 CUB_dom
     IPR001507 ZP_dom

    Graphical View of Domain Structure for InterPro Entry Q86UP6

    ProtoNet protein and cluster: Q86UP6

    2 Blocks protein families:
    IPB000859 CUB domain
    IPB001507 Endoglin/CD105 antigen


    UniProtKB/Swiss-Prot: CUZD1_HUMAN, Q86UP6
    Similarity: Contains 2 CUB domains
    Similarity: Contains 1 ZP domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CUZD1_HUMAN, Q86UP6
    Function: CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in
    these processes. May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic
    acinar cells

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: CUZD1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CUZD1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CUZD1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CUZD1 (see all 7)
    OriGene shRNA RFP: CUZD1
    OriGene siRNA: CUZD1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CUZD1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CUZD1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CUZD1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CUZD1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CUZD1 (NM_022034)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CUZD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUZD1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CUZD1
    Search LifeMap BioReagents cell lines for CUZD1

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUZD1

    1 GenomeRNAi human phenotype for CUZD1:
     Increased G2M DNA content 

    Animal Models:
         Mouse knock-out Cuzd1tm1Ljm for CUZD1
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cuzd1):
     endocrine/exocrine gland  immune system  mortality/aging 

    CUZD1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CUZD1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CUZD1 (Q86UP63 ENSP000003579004) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN6P293503, ENSP000003915924I2D: score=1 STRING: ENSP00000391592
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006931substrate-dependent cell migration, cell attachment to substrate NAS15184879
    GO:0007049cell cycle IEA--
    GO:0008283cell proliferation NAS15184879
    GO:0009755hormone-mediated signaling pathway ----
    GO:0032023trypsinogen activation ISS--


    CUZD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CUZD1
    Search CenterWatch for drugs/clinical trials and news about CUZD1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CUZD1 gene: 
    NM_022034.5  

    Unigene Cluster for CUZD1:

    CUB and zona pellucida-like domains 1
    Hs.647182  [show with all ESTs]
    Unigene Representative Sequence: NR_037915
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368904(uc009yaf.3 uc001lgr.3 uc010qty.2 uc009yae.3 uc001lgs.3)
    ENST00000368901 ENST00000368900 ENST00000338948 ENST00000368899(uc001lgp.3 uc009yad.3)
    ENST00000545804(uc010qtz.2) ENST00000392790

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: CUZD1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CUZD1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CUZD1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CUZD1 (see all 7)
    OriGene shRNA RFP: CUZD1
    OriGene siRNA: CUZD1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CUZD1
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CUZD1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CUZD1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CUZD1 (NM_022034)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CUZD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUZD1 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CUZD1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CUZD1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CUZD1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CUZD1

    Additional cDNA sequence: 

    AF305835.1 AK289445.1 AY260047.1 AY260048.1 AY260049.1 AY260050.1 BC136755.1 BC144398.1 
    BX538283.1 BX538284.1 BX648572.1 NR_037912.1 NR_037915.1 

    4 DOTS entries:

    DT.405801  DT.101978936  DT.100685727  DT.95175918 

    24/65 AceView cDNA sequences (see all 65):

    BQ018236 AY260050 AA732367 AL703960 AA723941 AL832795 BQ778339 AY260047 
    AI005145 AI378918 AL832386 AA917882 BX495744 AY260049 BX096610 AY260048 
    AA417006 BG142227 AY358556 BU602099 CB104559 BG490871 BM691616 AV745453 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CUZD1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                                        -     -                                   -                                             
    SP2:                                                                                      -           -                                             
    SP3:                                                                                      -           -           -                                 
    SP4:                          -     -                                                                                                               
    SP5:                          -     -     -                                                                                                         


    ECgene alternative splicing isoforms for CUZD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CUZD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTCTCCAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    CUZD1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    PancreasIslets of LangerhansMature Beta CellsPancreas
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See CUZD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CUZD1

    SOURCE GeneReport for Unigene cluster: Hs.647182

    UniProtKB/Swiss-Prot: CUZD1_HUMAN, Q86UP6
    Tissue specificity: Detected in pancreas and epithelium of ovary. Expressed at higher levels in ovarian tumors than in
    normal tissue

        SABiosciences Custom PCR Arrays for CUZD1
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CUZD1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CUZD1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CUZD1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CUZD1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUZD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CUZD1 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cuzd11 , 5 CUB and zona pellucida-like domains 11, 5 77.32(n)1
    70.51(a)1
      7 (73.81 cM)5
    164331  NM_008411.31  NP_032437.31 
     1313085555 
    chicken
    (Gallus gallus)
    Aves CUZD16
    Uncharacterized protein
    53(a)
    1 ↔ 1
    6(32952523-32959959)
    lizard
    (Anolis carolinensis)
    Reptilia CUZD16
    --
    32(a)
    1 ↔ 1
    AAWZ02036376(111-17531)
    zebrafish
    (Danio rerio)
    Actinopterygii AL773596.36
    AL773596.16
    (see all 5)
    --
    37(a)
    36(a)
    (see all 5)
    possible ortholog
    possible ortholog
    (see all 5)
    17(21700057-21709731)
    17(21689121-21692297)


    ENSEMBL Gene Tree for CUZD1 (if available)
    TreeFam Gene Tree for CUZD1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CUZD1 gene
    DMBT12  
    1 SIMAP similar gene for CUZD1 using alignment to 1 protein entry:     CUZD1_HUMAN:
    DMBT1

    CUZD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/296 NCBI SNPs in CUZD1 are shown (see all 296    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1148086541,2
    --124591228(+) AAAATG/ATTTTG 3 -- int1 ds50011Minor allele frequency- A:0.01WA 118
    rs79116741,2
    C--124591278(+) tttttG/Ttttgt 3 -- ds5001 int10--------
    rs1995680811,2
    --124591281(+) TTTTT-/TGTTTTT 3 -- int1 ds50010--------
    rs1385653781,2
    C,--124591282(+) TTTTT-/GTTTTT 3 -- ds5001 int10--------
    rs1496246591,2
    --124591336(+) ATGGCA/GTGATC 3 -- ds5001 int10--------
    rs79081961,2
    C,--124591555(+) TAGGCG/ATGAGC 3 -- int1 ds500110Minor allele frequency- A:0.00NA WA CSA 19
    rs1826944271,2
    --124591641(+) TCCATA/CGTCTT 3 -- int1 ds50010--------
    rs1876395281,2
    --124591732(+) AGCCAC/GGAGGT 3 -- nc-transcript-variantut310--------
    rs1899381401,2
    C,--124591806(+) TTCTGC/TAGCTT 4 L nc-transcript-variantsyn10--------
    rs2001737781,2
    --124591831(+) CTGCCC/TGTTGA 4 Q R nc-transcript-variantmis10--------

    HapMap Linkage Disequilibrium report for CUZD1 (124591665 - 124639146 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CUZD1
         1 CNV: 4714

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CUZD1
    DNA2.0 Custom Variant and Variant Library Synthesis for CUZD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CUZD1 for disorders           About GeneDecksing

    2 diseases for CUZD1:    About MalaCards
    ovarian cancer    pancreatitis


    Export disorders for CUZD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CUZD1 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with CUZD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    2. Molecular cloning, characterization and isolation of novel spliced variants of the human ortholog of a rat estrogen-regulated membrane- associated protein, UO-44. (PubMed id 15184879)1, 2 Leong C.T.C....Huynh H. (2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. Cloning and uterus/oviduct-specific expression of a novel estrogen-regulated gene (ERG1) (PubMed id 10542259)1, 3 Chen D....Bagchi I.C. (1999)
    5. Silencing expression of UO-44 (CUZD1) using small interfering RNA sensitizes human ovarian cancer cells to cisplatin in vitro. (PubMed id 16862170)1, 9 Leong C.T....Huynh H. (2007)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    7. Substrate-trapping techniques in the identification of cellular PTP targets. (PubMed id 15588985)1 Blanchetot C....Tremblay M.L. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    10. Modulation of the ERG K+ current by the tyrosine phosphatase, SHP-1. (PubMed id 12361947)1 Cayabyab F.S....Schlichter L.C. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 50624 HGNC: 17937 AceView: CUZD1 Ensembl:ENSG00000138161 euGenes: HUgn50624
    ECgene: CUZD1 H-InvDB: CUZD1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CUZD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CUZD1 gene:
    Search GeneIP for patents involving CUZD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for CUZD1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CUZD1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CUZD1  
     OriGene Protein Over-expression Lysate for CUZD1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CUZD1   OriGene 3'-UTR Clone for CUZD1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CUZD1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CUZD1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CUZD1   OriGene Custom Protein Services for CUZD1  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CUZD1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CUZD1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CUZD1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CUZD1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CUZD1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CUZD1
     GenScript Custom Purified and Recombinant Proteins Services for CUZD1 GenScript cDNA clones with any tag delivered in your preferred vector for CUZD1
     GenScript Custom Assay Services for CUZD1 GenScript Custom Superior Antibodies Services for CUZD1
     GenScript Custom overexpressing Cell Line Services for CUZD1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CUZD1 promoter
     Search Chromatin IP Primers for CUZD1
     RT2 qPCR Primer Assay in human, mouse, rat CUZD1
     Search GNC Networks for CUZD1
     SABiosciences Custom PCR Arrays for CUZD1
     Search Tocris compounds for CUZD1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CUZD1 antibodies
     CUZD1 proteins
     Search for Antibodies for CUZD1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CUZD1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     CUZD1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CUZD1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUZD1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CUZD1
     Browse SwitchGear Promoter luciferase reporter plasmids for CUZD1
     Search ThermoFisher Antibodies for CUZD1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUZD1
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CUZD1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4