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CUZD1 Gene

protein-coding   GIFtS: 47
GCID: GC10M124582

CUB And Zona Pellucida-Like Domains 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CUB And Zona Pellucida-Like Domains 11 2     UO-442
Transmembrane Protein UO-442 3     CUB And Zona Pellucida-Like Domain-Containing Protein 12
CUB And ZP Domain-Containing Protein 12 3     Estrogen Regulated Gene 12
ERG-12     

External Ids:    HGNC: 179371   Entrez Gene: 506242   Ensembl: ENSG000001381617   UniProtKB: Q86UP63   

Export aliases for CUZD1 gene to outside databases

Previous GC identifers: GC10M124132 GC10M118209


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CUZD1 Gene:
CUZD1 (CUB and zona pellucida-like domains 1) is a protein-coding gene.

UniProtKB/Swiss-Prot: CUZD1_HUMAN, Q86UP6
Function: CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in
these processes. May also play a role in the uterus during late pregnancy and/or in trypsin activation in
pancreatic acinar cells

Gene Wiki entry for CUZD1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the CUZD1 gene promoter:
         HOXA9   HOXA9B   C/EBPbeta   Nkx2-5   Cdc5   Meis-1b   Evi-1   MZF-1   AREB6   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CUZD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CUZD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.13   Ensembl cytogenetic band:  10q26.13   HGNC cytogenetic band: 10q26.13

CUZD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CUZD1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M124582:  view genomic region     (about GC identifiers)

Start:
124,591,665 bp from pter      End:
124,639,146 bp from pter
Size:
47,482 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CUZD1

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CUZD1_HUMAN, Q86UP6 (See protein sequence)
Recommended Name: CUB and zona pellucida-like domain-containing protein 1 precursor  
Size: 607 amino acids; 68153 Da
Sequence caution: Sequence=AAG23215.1; Type=Frameshift; Positions=Several;
Secondary accessions: A8K080 B2RN93 D3DRE5 Q7Z660 Q7Z661 Q86SG1 Q86UP5 Q9HAR7
Alternative splicing: 3 isoforms:  Q86UP6-1   Q86UP6-2   Q86UP6-3   

Explore the universe of human proteins at neXtProt for CUZD1: NX_Q86UP6

Explore proteomics data for CUZD1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn29, Asn57, Asn67, Asn271, Asn394, Asn419

  • See CUZD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071317.2  
    ENSEMBL proteins: 
     ENSP00000357900   ENSP00000357897   ENSP00000357896   ENSP00000340905   ENSP00000441590  
     ENSP00000376540  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000859 CUB_dom
     IPR001507 ZP_dom

    Graphical View of Domain Structure for InterPro Entry Q86UP6

    ProtoNet protein and cluster: Q86UP6

    2 Blocks protein domains:
    IPB000859 CUB domain
    IPB001507 Endoglin/CD105 antigen


    UniProtKB/Swiss-Prot: CUZD1_HUMAN, Q86UP6
    Similarity: Contains 2 CUB domains
    Similarity: Contains 1 ZP domain


    Find genes that share domains with CUZD1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CUZD1_HUMAN, Q86UP6
    Function: CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in
    these processes. May also play a role in the uterus during late pregnancy and/or in trypsin activation in
    pancreatic acinar cells

    Phenotypes:
         1 GenomeRNAi human phenotype for CUZD1:

     Increased G2M DNA content 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cuzd1):
     endocrine/exocrine gland  immune system  mortality/aging 

    Find genes that share phenotypes with CUZD1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cuzd1tm1Ljm for CUZD1

       genOway: Develop your customized and physiologically relevant rodent model for CUZD1

    miRNA
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    miRTarBase miRNAs that target CUZD1:
    hsa-mir-192-5p (MIRT026847), hsa-mir-503-5p (MIRT041100), hsa-mir-215-5p (MIRT024595)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CUZD1_HUMAN, Q86UP6: Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type I membrane protein (By
    similarity). Note=Associated with zymogen granule membranes (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular2
    endoplasmic reticulum1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane NAS15184879
    GO:0030658transport vesicle membrane IEA--
    GO:0042588zymogen granule ----
    GO:0042589zymogen granule membrane ISS--

    Find genes that share ontologies with CUZD1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CUZD1
    Interactions:

        Search GeneGlobe Interaction Network for CUZD1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CUZD1 (Q86UP63 ENSP000003579004) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN6P293503, ENSP000003915924I2D: score=1 STRING: ENSP00000391592
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006931substrate-dependent cell migration, cell attachment to substrate NAS15184879
    GO:0007049cell cycle IEA--
    GO:0008283cell proliferation NAS15184879
    GO:0032023trypsinogen activation ISS--
    GO:0051301cell division IEA--

    Find genes that share ontologies with CUZD1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for CUZD1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CUZD1 gene: 
    NM_022034.5  

    Unigene Cluster for CUZD1:

    CUB and zona pellucida-like domains 1
    Hs.647182  [show with all ESTs]
    Unigene Representative Sequence: NR_037915
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368904(uc009yaf.3 uc001lgr.3 uc010qty.2 uc009yae.3 uc001lgs.3)
    ENST00000368899(uc001lgp.3 uc009yad.3) ENST00000368901 ENST00000368900
    ENST00000338948 ENST00000545804(uc010qtz.2) ENST00000392790
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    Additional mRNA sequence: 

    AF305835.1 AK289445.1 AY260047.1 AY260048.1 AY260049.1 AY260050.1 BC136755.1 BC144398.1 
    BX538283.1 BX538284.1 BX648572.1 NR_037912.1 NR_037915.1 

    4 DOTS entries:

    DT.405801  DT.101978936  DT.100685727  DT.95175918 

    Selected AceView cDNA sequences (see all 65):

    BX096610 BQ778339 AL832386 AY260047 AA723941 AA732367 AI005145 AL832795 
    AA917882 BX495744 AL703960 AY260049 AY260048 AI378918 AY260050 AA417006 
    BQ018236 BX499442 BM047266 NM_022034 BX282650 BX538283 AA367179 BG490871 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CUZD1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                                        -     -                                   -                                             
    SP2:                                                                                      -           -                                             
    SP3:                                                                                      -           -           -                                 
    SP4:                          -     -                                                                                                               
    SP5:                          -     -     -                                                                                                         


    ECgene alternative splicing isoforms for CUZD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CUZD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCTCCAGG
    CUZD1 Expression
    About this image


    CUZD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Duct Cells Pancreatic Ducts
             Islets of Langerhans
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
    CUZD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CUZD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.647182

    UniProtKB/Swiss-Prot: CUZD1_HUMAN, Q86UP6
    Tissue specificity: Detected in pancreas and epithelium of ovary. Expressed at higher levels in ovarian tumors
    than in normal tissue

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CUZD1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cuzd11 , 5 CUB and zona pellucida-like domains 11, 5 77.32(n)1
    70.51(a)1
      7 (73.81 cM)5
    164331  NM_008411.31  NP_032437.31 
     1313085555 
    chicken
    (Gallus gallus)
    Aves CUZD16
    CUB and zona pellucida-like domains 1
    55(a)
    1 ↔ 1
    6(30920006-30927511)
    lizard
    (Anolis carolinensis)
    Reptilia CUZD16
    CUB and zona pellucida-like domains 1
    33(a)
    1 ↔ 1
    AAWZ02036376(41-19768)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004851791 CUB and zona pellucida-like domain-containing protein more 53.85(n)
    46.39(a)
      100485179  XM_002937794.2  XP_002937840.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5557681 deleted in malignant brain tumors 1 protein-like 50.6(n)
    40.67(a)
      555768  XM_678384.6  XP_683476.4 


    ENSEMBL Gene Tree for CUZD1 (if available)
    TreeFam Gene Tree for CUZD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CUZD1 gene
    1 SIMAP similar gene for CUZD1 using alignment to 1 protein entry:     CUZD1_HUMAN:
    DMBT1

    Find genes that share paralogs with CUZD1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for CUZD1    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs351202571,2,4
    ----see VAR_0619922 mis40--------

    HapMap Linkage Disequilibrium report for CUZD1 (124591665 - 124639146 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CUZD1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv896064CNV Loss21882294
    nsv832010CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CUZD1 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with CUZD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    2. Molecular cloning, characterization and isolation of novel spliced variants of the human ortholog of a rat estrogen-regulated membrane- associated protein, UO-44. (PubMed id 15184879)1, 2 Leong C.T.C....Huynh H. (Oncogene 2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    4. Cloning and uterus/oviduct-specific expression of a novel estrogen-regulated gene (ERG1) (PubMed id 10542259)1, 3 Chen D....Bagchi I.C. (J. Biol. Chem. 1999)
    5. Silencing expression of UO-44 (CUZD1) using small interfering RNA sensitizes human ovarian cancer cells to cisplatin in vitro. (PubMed id 16862170)1, 9 Leong C.T....Huynh H. (Oncogene 2007)
    6. CUZD1 and anti-CUZD1 antibodies as markers of cancer and inflammatory bowel diseases. (PubMed id 23710207)1 Liaskos C....Papandreou C.N. (amp 2013)
    7. CUB and zona pellucida-like domain-containing protein 1 (CUZD1): a novel serological biomarker for ovarian cancer. (PubMed id 22985796)1 Leung F....Diamandis E.P. (Clin. Biochem. 2012)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    9. Substrate-trapping techniques in the identification of cellular PTP targets. (PubMed id 15588985)1 Blanchetot C....Tremblay M.L. (Methods 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 50624 HGNC: 17937 AceView: CUZD1 Ensembl:ENSG00000138161 euGenes: HUgn50624
    ECgene: CUZD1 H-InvDB: CUZD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CUZD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CUZD1 gene:
    Search GeneIP for patents involving CUZD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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