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Aliases for CUX2 Gene

Aliases for CUX2 Gene

  • Cut Like Homeobox 2 2 3
  • Cut-Like Homeobox 2 2 3 5
  • Homeobox Protein Cux-2 3 4
  • CUTL2 3 4
  • Cut-Like 2 (Drosophila) 2
  • KIAA0293 4
  • CDP2 3

External Ids for CUX2 Gene

Previous HGNC Symbols for CUX2 Gene

  • CUTL2

Previous GeneCards Identifiers for CUX2 Gene

  • GC12P109956
  • GC12P111471
  • GC12P108667

Summaries for CUX2 Gene

Entrez Gene Summary for CUX2 Gene

  • This gene encodes a protein which contains three CUT domains and a homeodomain; both domains are DNA-binding motifs. A similar gene, whose gene product possesses different DNA-binding activities, is located on chromosome on chromosome 7. Two pseudogenes of this gene have been identified on chromosomes 10 and 4. [provided by RefSeq, Jan 2013]

GeneCards Summary for CUX2 Gene

CUX2 (Cut Like Homeobox 2) is a Protein Coding gene. Diseases associated with CUX2 include Fiedler's Myocarditis and Acute Myocarditis. GO annotations related to this gene include sequence-specific DNA binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is ONECUT1.

UniProtKB/Swiss-Prot for CUX2 Gene

  • May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUX2 Gene

Genomics for CUX2 Gene

Regulatory Elements for CUX2 Gene

Enhancers for CUX2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CUX2 on UCSC Golden Path with GeneCards custom track

Promoters for CUX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CUX2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CUX2 Gene

Chromosome:
12
Start:
111,034,024 bp from pter
End:
111,350,554 bp from pter
Size:
316,531 bases
Orientation:
Plus strand

Genomic View for CUX2 Gene

Genes around CUX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CUX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CUX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUX2 Gene

Proteins for CUX2 Gene

  • Protein details for CUX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14529-CUX2_HUMAN
    Recommended name:
    Homeobox protein cut-like 2
    Protein Accession:
    O14529
    Secondary Accessions:
    • A7E2Y4

    Protein attributes for CUX2 Gene

    Size:
    1486 amino acids
    Molecular mass:
    161677 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA22962.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CUX2 Gene

neXtProt entry for CUX2 Gene

Proteomics data for CUX2 Gene at MOPED

Post-translational modifications for CUX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CUX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CUX2 Gene

Domains & Families for CUX2 Gene

Gene Families for CUX2 Gene

Protein Domains for CUX2 Gene

Suggested Antigen Peptide Sequences for CUX2 Gene

Graphical View of Domain Structure for InterPro Entry

O14529

UniProtKB/Swiss-Prot:

CUX2_HUMAN :
  • Contains 3 CUT DNA-binding domains.
  • Belongs to the CUT homeobox family.
Domain:
  • Contains 3 CUT DNA-binding domains.
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the CUT homeobox family.
genes like me logo Genes that share domains with CUX2: view

Function for CUX2 Gene

Molecular function for CUX2 Gene

UniProtKB/Swiss-Prot Function:
May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity).

Gene Ontology (GO) - Molecular Function for CUX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA,ISS --
genes like me logo Genes that share ontologies with CUX2: view
genes like me logo Genes that share phenotypes with CUX2: view

Animal Models for CUX2 Gene

MGI Knock Outs for CUX2:

Animal Model Products

CRISPR Products

miRNA for CUX2 Gene

Targeted motifs for CUX2 Gene
HOMER Transcription Factor Regulatory Elements motif CUX2
  • Consensus sequence: HNRAATCAAT Submotif: canonical Cell Type: Liver GEO ID: GSE35985

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for CUX2 Gene

Localization for CUX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CUX2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CUX2 Gene COMPARTMENTS Subcellular localization image for CUX2 gene
Compartment Confidence
extracellular 5
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for CUX2 Gene

Pathways & Interactions for CUX2 Gene

SuperPathways for CUX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CUX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007614 short-term memory IEA,ISS --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
GO:0050890 cognition IMP 15389760
genes like me logo Genes that share ontologies with CUX2: view

No data available for Pathways by source and SIGNOR curated interactions for CUX2 Gene

Drugs & Compounds for CUX2 Gene

No Compound Related Data Available

Transcripts for CUX2 Gene

Unigene Clusters for CUX2 Gene

Cut-like homeobox 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CUX2 Gene

No ASD Table

Relevant External Links for CUX2 Gene

GeneLoc Exon Structure for
CUX2
ECgene alternative splicing isoforms for
CUX2

Expression for CUX2 Gene

mRNA expression in normal human tissues for CUX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CUX2 Gene

This gene is overexpressed in Liver (x11.2), Brain - Cortex (x9.4), Brain - Frontal Cortex (BA9) (x8.1), and Brain - Anterior cingulate cortex (BA24) (x5.3).

Protein differential expression in normal tissues from HIPED for CUX2 Gene

This gene is overexpressed in Rectum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CUX2 Gene



SOURCE GeneReport for Unigene cluster for CUX2 Gene Hs.124953

genes like me logo Genes that share expression patterns with CUX2: view

Protein tissue co-expression partners for CUX2 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CUX2 Gene

Orthologs for CUX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CUX2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CUX2 35
  • 88.99 (n)
  • 91.49 (a)
CUX2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CUX2 35
  • 88.83 (n)
  • 92.52 (a)
CUX2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cux2 35
  • 81.45 (n)
  • 83.42 (a)
Cux2 16
Cux2 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CUX2 35
  • 99.43 (n)
  • 99.41 (a)
CUX2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cux2 35
  • 81.84 (n)
  • 82.93 (a)
oppossum
(Monodelphis domestica)
Mammalia CUX2 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CUX2 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves CUX2 35
  • 74.12 (n)
  • 74.54 (a)
CUX2 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CUX2 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cux2 35
  • 64.08 (n)
  • 66.6 (a)
zebrafish
(Danio rerio)
Actinopterygii cux2 35
  • 64.28 (n)
  • 62.6 (a)
cux2b 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ct 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ceh-44 36
  • 24 (a)
OneToMany
Species with no ortholog for CUX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CUX2 Gene

ENSEMBL:
Gene Tree for CUX2 (if available)
TreeFam:
Gene Tree for CUX2 (if available)

Paralogs for CUX2 Gene

Paralogs for CUX2 Gene

(2) SIMAP similar genes for CUX2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for CUX2 Gene

genes like me logo Genes that share paralogs with CUX2: view

Variants for CUX2 Gene

Sequence variations from dbSNP and Humsavar for CUX2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs6490073 - 111,348,278(+) ACCGA(C/G)TAGAG reference, missense
rs1965012 -- 111,335,663(-) gtggt(A/G)caatc intron-variant
rs1985097 -- 111,164,302(-) cacca(C/T)gtccc intron-variant
rs2009170 -- 111,265,509(+) GCTAA(C/T)TTTTT intron-variant
rs7133244 -- 111,127,863(+) caggg(A/C)aattc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CUX2 Gene

Variant ID Type Subtype PubMed ID
esv25829 CNV Loss 19812545
esv2659278 CNV Deletion 23128226
esv2665858 CNV Deletion 23128226
esv22627 CNV Loss 19812545
nsv832513 CNV Gain 17160897
esv2746357 CNV Deletion 23290073
esv2746358 CNV Deletion 23290073
nsv455714 CNV Loss 19166990
esv2667290 CNV Deletion 23128226
nsv513366 CNV Insertion 21212237

Variation tolerance for CUX2 Gene

Residual Variation Intolerance Score: 5.45% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.35; 63.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CUX2 Gene

Human Gene Mutation Database (HGMD)
CUX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CUX2 Gene

Disorders for CUX2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CUX2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
fiedler's myocarditis
  • fiedler myocarditis
acute myocarditis
- elite association - COSMIC cancer census association via MalaCards
Search CUX2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CUX2

Genetic Association Database (GAD)
CUX2
Human Genome Epidemiology (HuGE) Navigator
CUX2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CUX2
genes like me logo Genes that share disorders with CUX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CUX2 Gene

Publications for CUX2 Gene

  1. 1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 Data. (PMID: 22293688) Huang J. … Li Y. (Eur. J. Hum. Genet. 2012) 3 48 67
  2. CUX2, a potential regulator of NCAM expression: genomic characterization and analysis as a positional candidate susceptibility gene for bipolar disorder. (PMID: 11353453) Jacobsen N.J.O. … Owen M.J. (Am. J. Med. Genet. 2001) 3 23
  3. CUX2 protein functions as an accessory factor in the repair of oxidative DNA damage. (PMID: 26221032) Pal R. … Nepveu A. (J. Biol. Chem. 2015) 3
  4. A genome-wide association study of a coronary artery disease risk variant. (PMID: 23364394) Lee J.Y. … Lee J.Y. (J. Hum. Genet. 2013) 3
  5. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PMID: 19401682) Maestrini E. … Monaco A.P. (Mol. Psychiatry 2010) 3

Products for CUX2 Gene

Sources for CUX2 Gene

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