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CUX2 Gene

protein-coding   GIFtS: 54
GCID: GC12P111471

Cut-Like Homeobox 2

(Previous name: cut-like 2 (Drosophila))
(Previous symbol: CUTL2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cut-Like Homeobox 21 2     CDP22
CUTL21 2 3     Homeobox Protein Cut-Like 22
Homeobox Protein Cux-22 3     KIAA02933
Cut-Like 2 (Drosophila)1     

External Ids:    HGNC: 193471   Entrez Gene: 233162   Ensembl: ENSG000001112497   OMIM: 6106485   UniProtKB: O145293   

Export aliases for CUX2 gene to outside databases

Previous GC identifers: GC12P109956 GC12P108667


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CUX2 Gene:
This gene encodes a protein which contains three CUT domains and a homeodomain; both domains are DNA-binding
motifs. A similar gene, whose gene product possesses different DNA-binding activities, is located on chromosome
on chromosome 7. Two pseudogenes of this gene have been identified on chromosomes 10 and 4. (provided by RefSeq,
Jan 2013)

GeneCards Summary for CUX2 Gene:
CUX2 (cut-like homeobox 2) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ONECUT1.

UniProtKB/Swiss-Prot: CUX2_HUMAN, O14529
Function: May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific
manner (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CUX2 gene promoter:
         STAT5B   Pax-5   HTF   IRF-1   HNF-4alpha2   CUTL1   Cdc5   HNF-4alpha1   Ik-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCUX2 promoter sequence
   Search Chromatin IP Primers for CUX2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CUX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.12   Ensembl cytogenetic band:  12q24.11   HGNC cytogenetic band: 12q24.12

CUX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CUX2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P111471:  view genomic region     (about GC identifiers)

Start:
111,471,828 bp from pter      End:
111,788,358 bp from pter
Size:
316,531 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CUX2_HUMAN, O14529 (See protein sequence)
Recommended Name: Homeobox protein cut-like 2  
Size: 1486 amino acids; 161677 Da
Sequence caution: Sequence=BAA22962.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for CUX2:
1WH6 (3D)        1WH8 (3D)        1X2L (3D)    
Secondary accessions: A7E2Y4

Explore the universe of human proteins at neXtProt for CUX2: NX_O14529

Explore proteomics data for CUX2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CUX2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056082.2  
    ENSEMBL proteins: 
     ENSP00000261726   ENSP00000380765  

    CUX2 Human Recombinant Protein Products:

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    Novus Biologicals CUX2 Protein
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    Cloud-Clone Corp. Proteins for CUX2

     
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    antibodies-online proteins for CUX2 (2 products) 

     
    antibodies-online peptides for CUX2

    CUX2 Antibody Products:

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    antibodies-online antibodies for CUX2 (18 products) 

    CUX2 Assay Products:

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    Cloud-Clone Corp. ELISAs for CUX2
    Cloud-Clone Corp. CLIAs for CUX2
    Search eBioscience for ELISAs for CUX2 
    antibodies-online kits for CUX2 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CUT: Homeoboxes / CUT class

    5 InterPro protein domains:
     IPR010982 Lambda_DNA-bd_dom
     IPR003350 Hmoeo_CUT
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry O14529

    ProtoNet protein and cluster: O14529

    1 Blocks protein domain: IPB003350 Homeodomain protein CUT

    UniProtKB/Swiss-Prot: CUX2_HUMAN, O14529
    Similarity: Belongs to the CUT homeobox family
    Similarity: Contains 3 CUT DNA-binding domains
    Similarity: Contains 1 homeobox DNA-binding domain


    Find genes that share domains with CUX2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CUX2_HUMAN, O14529
    Function: May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific
    manner (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding ISS--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IDA15656993
         
    Find genes that share ontologies with CUX2           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Cux2):
     cellular  embryogenesis  mortality/aging  nervous system  no phenotypic analysis 

    Find genes that share phenotypes with CUX2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cux2tm1.1Nieto for CUX2

       genOway: Develop your customized and physiologically relevant rodent model for CUX2

    miRNA
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    miRTarBase miRNAs that target CUX2:
    hsa-mir-124-3p (MIRT022380)

    Block miRNA regulation of human, mouse, rat CUX2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CUX2 (see all 70):
    hsa-miR-124* hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-376b hsa-miR-605 hsa-miR-519a hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidCUX2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CUX2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: CUX2 (NM_015267)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUX2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUX2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CUX2_HUMAN, O14529: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    golgi apparatus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15656993
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with CUX2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CUX2
    Interactions:

        GeneGlobe Interaction Network for CUX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CUX2 (O145293 ENSP000002617264) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    CSNK2A1P684003, ENSP000002172444I2D: score=1 STRING: ENSP00000217244
    ERGP113083, ENSP000003818914I2D: score=1 STRING: ENSP00000381891
    DLG4P783523I2D: score=1 
    HDAC1Q135473I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA15656993
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007614short-term memory ISS--
    GO:0010628positive regulation of gene expression ISS--

    Find genes that share ontologies with CUX2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CUX2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CUX2 gene: 
    NM_015267.3  

    Unigene Cluster for CUX2:

    Cut-like homeobox 2
    Hs.124953  [show with all ESTs]
    Unigene Representative Sequence: BC151245
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261726(uc001tsa.2) ENST00000397643(uc001tsb.2) ENST00000551604

    miRNA
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    Block miRNA regulation of human, mouse, rat CUX2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CUX2 (see all 70):
    hsa-miR-124* hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-376b hsa-miR-605 hsa-miR-519a hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidCUX2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CUX2
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CUX2 (NM_015267)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CUX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUX2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CUX2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CUX2
      QuantiTect SYBR Green Assays in human, mouse, rat CUX2
      QuantiFast Probe-based Assays in human, mouse, rat CUX2

    Additional mRNA sequence: 

    AB006631.2 AF234996.1 AF271236.1 BC151245.1 

    3 DOTS entries:

    DT.313213  DT.121110137  DT.92016077 

    Selected AceView cDNA sequences (see all 35):

    AA593578 CK300340 F02605 F09735 AF271236 BF446155 AB006631 BM691900 
    F12097 BE255767 AF234996 Z43134 BX283453 BU728601 BM804306 BG060008 
    AW023436 AW514237 T65238 BQ187120 AW948980 AI126128 H05795 BQ055126 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CUX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAGGCTGA
    CUX2 Expression
    About this image


    CUX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Blood (Hematopoietic System)
             Plasmacytoid Dendritic cells Peripheral Blood
    CUX2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CUX2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.124953
        Custom PCR Arrays for CUX2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUX2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CUX2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cux21 , 5 cut-like homeobox 21, 5 81.45(n)1
    83.42(a)1
      5 (62.02 cM)5
    130481  NM_007804.21  NP_031830.21 
     1218583875 
    chicken
    (Gallus gallus)
    Aves CUX21 cut-like homeobox 2 74.12(n)
    74.54(a)
      416875  XM_415167.4  XP_415167.4 
    lizard
    (Anolis carolinensis)
    Reptilia CUX26
    cut-like homeobox 2
    70(a)
    1 ↔ 1
    GL343423.1(512853-654956)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cux21 cut-like homeobox 2 64.08(n)
    66.6(a)
      100038096  NM_001134814.2  NP_001128286.2 
    zebrafish
    (Danio rerio)
    Actinopterygii BI867269.12   -- 78.63(n)    BI867269.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ct6
    cut
    17(a)
    1 → many
    X(7503181-7572892)
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-446
    Protein CEH-44, isoform a (ceh-44) mRNA, complete ...
    24(a)
    1 → many
    III(2530615-2546417) WBGene00000464


    ENSEMBL Gene Tree for CUX2 (if available)
    TreeFam Gene Tree for CUX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CUX2 gene
    ONECUT12  ONECUT22  ONECUT32  CUX12  
    2 SIMAP similar genes for CUX2 using alignment to 4 protein entries:     CUX2_HUMAN (see all proteins):
    Nbla10317    CUX1

    Find genes that share paralogs with CUX2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CUX2
    PGOHUM00000261080


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CUX2 (see all 5848)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1868294541,2
    --108488394(+) TCCGCC/GCCCCG 1 -- int10--------
    rs750208071,2
    C--108574964(+) TTTTTC/TTTTTT 1 -- int10--------
    rs2021324591,2
    --108609531(+) AAAAA-/ATAAAAA 1 -- int10--------
    rs2007183641,2
    --108612923(+) TTTTT-/TTCCTAGA 1 -- int10--------
    rs2014678401,2
    C--108612924(+) TTTTT-/TCCTAGA 1 -- int10--------
    rs783218751,2
    C--108614995(+) AGAGT-/CTGGTTC 1 -- int10--------
    rs118366471,2
    C,F,H--108620226(+) gagggG/Cccagg 1 -- int13Minor allele frequency- C:0.02NS NA 126
    rs118321251,2
    C,F,H--108620228(+) ggggcC/Aaggct 1 -- int16Minor allele frequency- A:0.02NS EA NA 418
    rs340126731,2
    C--108628957(+) TTTTT-/T/TT  
            
    ACACT
    1 -- int11NA 2
    rs106236831,2
    C--108647533(+) TGCCA-/CTCTC/
    CTCTCAGCC
    AGGTT
    2 -- int1 cds10--------

    HapMap Linkage Disequilibrium report for CUX2 (111471828 - 111721828 bp, first 250kb of CUX2)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for CUX2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2746358CNV Deletion23290073
    esv2665858CNV Deletion23128226
    esv2667290CNV Deletion23128226
    esv2659278CNV Deletion23128226
    esv2746357CNV Deletion23290073
    nsv513366CNV Insertion21212237
    esv22627CNV Loss19812545
    esv25829CNV Loss19812545
    nsv455714CNV Loss19166990
    nsv832513CNV Gain17160897

    Human Gene Mutation Database (HGMD): CUX2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CUX2
    DNA2.0 Custom Variant and Variant Library Synthesis for CUX2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610648    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for CUX2:
    fiedler's myocarditis

    Find genes that share disorders with CUX2           About GenesLikeMe

    Genetic Association Database (GAD): CUX2
    Human Genome Epidemiology (HuGE) Navigator: CUX2 (5 documents)

    Export disorders for CUX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CUX2 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with CUX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. 1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 Data. (PubMed id 22293688)1, 4 Huang J....Li Y. (Eur. J. Hum. Genet. 2012)
    2. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    3. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PubMed id 19401682)1, 4 Maestrini E....Monaco A.P. (Mol. Psychiatry 2010)
    4. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. (PubMed id 19328558)1, 4 Yosifova A....Nakamura Y. (J Affect Disord 2009)
    5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    6. Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. (PubMed id 9179496)1, 2 Ohara O....Nomura N. (DNA Res. 1997)
    7. CUX2, a potential regulator of NCAM expression: genomic characterization and analysis as a positional candidate susceptibility gene for bipolar disorder. (PubMed id 11353453)1, 9 Jacobsen N.J.O.... Owen M.J. (Am. J. Med. Genet. 2001)
    8. A genome-wide association study of a coronary artery disease risk variant. (PubMed id 23364394)1 Lee J.Y....Lee J.Y. (J. Hum. Genet. 2013)
    9. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23316 HGNC: 19347 AceView: CUTL2 Ensembl:ENSG00000111249 euGenes: HUgn23316
    ECgene: CUX2 H-InvDB: CUX2

    (According to HUGE)
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    HUGE: KIAA0293

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CUX2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CUX2 gene:
    Search GeneIP for patents involving CUX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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