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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CUX2 Gene

protein-coding GIFtS: 51
GCID: GC12P111471

cut-like homeobox 2

(Previous name: cut-like 2 (Drosophila) )
(Previous symbol: CUTL2)

Explore 5 diseases affiliated with
CUX2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cut-Like Homeobox 2¹ ²		Homeobox Protein Cux-2² ³
CUTL2¹ ² ³		Cut-Like 2 (Drosophila)¹
CDP2¹ ²		Homeobox Protein Cut-Like 2²
KIAA0293¹ ³

External Ids:	HGNC: 19347¹	Entrez Gene: 23316²	Ensembl: ENSG00000111249⁷	OMIM: 610648⁵	UniProtKB: O14529³

Export aliases for CUX2 gene to outside databases

Previous GC identifers: GC12P109956 GC12P108667

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CUX2:

This gene encodes a protein which contains three CUT domains and a homeodomain; both domains are DNA-binding motifs. A

similar gene, whose gene product possesses different DNA-binding activities, is located on chromosome on chromosome 7.

Two pseudogenes of this gene have been identified on chromosomes 10 and 4. (provided by RefSeq, Jan 2013)

UniProtKB/Swiss-Prot: CUX2_HUMAN, O14529

Function: May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner

(By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009775.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CUX2 gene promoter:
STAT5B Pax-5 HTF IRF-1 HNF-4alpha2 CUTL1 Cdc5 HNF-4alpha1 Ik-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CUX2 promoter sequence

Search SABiosciences Chromatin IP Primers for CUX2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CUX2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.12 Ensembl cytogenetic band: 12q24.11 HGNC cytogenetic band: 12q24.12

CUX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CUX2 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P111471: view genomic region (about GC identifiers)

Start:	111,471,828 bp from pter	End:	111,788,358 bp from pter
Size:	316,531 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CUX2_HUMAN, O14529 (See protein sequence)

Recommended Name: Homeobox protein cut-like 2

Size: 1486 amino acids; 161677 Da

Subcellular location: Nucleus (By similarity)

Sequence caution: Sequence=BAA22962.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

3 PDB 3D structures from and Proteopedia for CUX2:

1WH6 (3D)

1WH8 (3D)

1X2L (3D)

Secondary accessions: A7E2Y4

Explore the universe of human proteins at neXtProt for CUX2: NX_O14529

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O14529

CUX2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_056082.2

ENSEMBL proteins:

ENSP00000261726 ENSP00000380765

Human Recombinant Protein Products:

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	Novus Biologicals CUX2 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CUX2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	--

CUX2 for ontologies About GeneDecksing

CUX2 Antibody Products:

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Assay Products for CUX2:

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	Uscn ELISAs and CLIAs for CUX2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CUX2 for domains About GeneDecksing

5 InterPro domains/families:

IPR010982 Lambda_DNA-bd_dom

IPR003350 Hmoeo_CUT

IPR017970 Homeobox_CS

IPR001356 Homeodomain

IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry O14529

ProtoNet protein and cluster: O14529

1 Blocks protein family: IPB003350 Homeodomain protein CUT

UniProtKB/Swiss-Prot: CUX2_HUMAN, O14529

Similarity: Belongs to the CUT homeobox family

Similarity: Contains 3 CUT DNA-binding domains

Similarity: Contains 1 homeobox DNA-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CUX2_HUMAN, O14529

Function: May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner

(By similarity)

miRNA Products:		OriGene 3'-UTR Clone: CUX2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CUX2
		8/70 QIAGEN miScript miRNA Assays for microRNAs that regulate CUX2 (see all 70):
		hsa-miR-124* hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-376b hsa-miR-605 hsa-miR-519a hsa-miR-342-3p

		SwitchGear 3'UTR luciferase reporter plasmid: CUX2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CUX2 (see all 4) OriGene shRNA RFP: CUX2 OriGene siRNA: CUX2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CUX2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CUX2

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CUX2
		Search LifeMap BioReagents cell lines for CUX2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUX2

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	NAS	--
GO:0043565	sequence-specific DNA binding	IEA	--

CUX2 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Cux2^tm1.1Nieto for CUX2
     5 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Cux2):

cellular

embryogenesis

mortality/aging

nervous system

no phenotypic analysis

CUX2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CUX2

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5/6 Interacting proteins for CUX2 (O14529³ ENSP00000261726⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AR	P10275³, ENSP00000363822⁴	I2D: score=1 STRING: ENSP00000363822
CSNK2A1	P68400³, ENSP00000217244⁴	I2D: score=1 STRING: ENSP00000217244
ERG	P11308³, ENSP00000381891⁴	I2D: score=1 STRING: ENSP00000381891
DLG4	P78352³	I2D: score=1
HDAC1	Q13547³	I2D: score=1

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	NAS	--
GO:0045892	negative regulation of transcription, DNA-dependent	IEA	--
GO:0071310	cellular response to organic substance	IEA	--

CUX2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CUX2
Search CenterWatch for drugs/clinical trials and news about CUX2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CUX2 gene:

NM_015267.3

Unigene Cluster for CUX2:

Cut-like homeobox 2

Hs.124953 [show with all ESTs]

Unigene Representative Sequence: BC151245

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000261726(uc001tsa.2) ENST00000397643(uc001tsb.2) ENST00000551604

miRNA Products:		OriGene 3'-UTR Clone: CUX2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CUX2
		8/70 QIAGEN miScript miRNA Assays for microRNAs that regulate CUX2 (see all 70):
		hsa-miR-124* hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-376b hsa-miR-605 hsa-miR-519a hsa-miR-342-3p

		SwitchGear 3'UTR luciferase reporter plasmid: CUX2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CUX2 (see all 4) OriGene shRNA RFP: CUX2 OriGene siRNA: CUX2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CUX2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CUX2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CUX2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CUX2 (NM_015267)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CUX2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUX2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CUX2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CUX2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CUX2

Additional cDNA sequence:

AB006631.2 AF234996.1 AF271236.1 BC151245.1

3 DOTS entries:

DT.313213 DT.121110137 DT.92016077

24/35 AceView cDNA sequences (see all 35):

BF446155 AF271236 F02605 F09735 CK300340 AB006631 AA593578 BG060008

BX283453 BE255767 BM691900 AF234996 F12097 BM804306 BU728601 Z43134

AW948980 H05795 T65238 AI126128 AW023436 AW514237 BQ187120 BQ055126

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CUX2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAAGGCTGA

About this image

CUX2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

Intervertebral disc (IVD) annulus fibrosus (AF) cells (Differentiation of s...)

Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CUX2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CUX2

SOURCE GeneReport for Unigene cluster: Hs.124953

SABiosciences Custom PCR Arrays for CUX2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CUX2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CUX2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CUX2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUX2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CUX2 gene from 8/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cux2^{1 , 5}	cut-like homeobox 2^{1, 5}	82.64(n)¹ 85.47(a)¹		5 (62.02 cM)⁵ 13048¹ NM_007804.2¹ NP_031830.2¹ 121857963⁵
chicken (Gallus gallus)	Aves	CUX2¹	cut-like homeobox 2	74.72(n) 75.54(a)		416875 XM_415167.3 XP_415167.3
lizard (Anolis carolinensis)	Reptilia	CUX2⁶	--	70(a)	1 ↔ 1	GL343423.1(597202-654956)
zebrafish (Danio rerio)	Actinopterygii	BI867269.1²	--	78.63(n)		BI867269.1
fruit fly (Drosophila melanogaster)	Insecta	ct⁶	cut	14(a)	1 ↔ 1	X(7503181-7572892)
worm (Caenorhabditis elegans)	Secernentea	ceh-44⁶	Protein CASP	20(a)	1 ↔ 1	III(2530603-2546408)
thale cress (Arabidopsis thaliana)	eudicotyledons	AtCASP⁶	protein CASP	18(a)	1 → many	3(6336736-6341788)
rice (Oryza sativa)	Liliopsida	--	CASP, putative, expressed	19(a)	1 → many	3(28664349-28672103)

ENSEMBL Gene Tree for CUX2 (if available)
TreeFam Gene Tree for CUX2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CUX2 gene

ONECUT1² ONECUT2² ONECUT3² CUX1²

2 SIMAP similar genes for CUX2 using alignment to 4 protein entries: CUX2_HUMAN (see all proteins):

Nbla10317 CUX1

CUX2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CUX2
PGOHUM00000261080

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78437457^1,2	F,	--	108485920(+)	`TCTTAC/TGCGTC`	1	--	us2k¹		1		WA	118
rs7316624^1,2	C,F,A,H,	--	108486392(+)	`TATGTA/GTCAGG`	1	--	us2k¹		8		NS WA CSA	360
rs76182568^1,2		--	108486639(+)	`ACCCCA/GGTTGT`	1	--	us2k¹		0	--	--	--	--
rs11065793^1,2	C,H	--	108486697(+)	`CTGAAG/AACCCT`	1	--	us2k¹		6		NS EA NA	422
rs7133580^1,2	C,F,	--	108488962(+)	`ACCCCG/CTAGGA`	1	--	int¹		5		WA CSA	125
rs73427608^1,2	C,F,	--	108489289(+)	`GCACCC/GGCGCC`	1	--	int¹		1		WA	118
rs76518476^1,2		--	108490124(+)	`GATGCA/GTAGAT`	1	--	int¹		1		NA	120
rs79541483^1,2	F,	--	108490871(+)	`CTGAGC/TATTAA`	1	--	int¹		1		WA	118
rs35389305^1,2		--	108491103(+)	`TTAATA/GACTTT`	1	--	int¹		0	--	--	--	--
rs112685583^1,2	C,	--	108491563(+)	`TTACAC/TAGTAC`	1	--	int¹		1		NA	2

HapMap Linkage Disequilibrium report for CUX2 (111471828 - 111721828 bp, first 250kb of CUX2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CUX2
1 CNV: 71579
1 Indel: 71580
Human Gene Mutation Database (HGMD): CUX2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CUX2

DNA2.0 Custom Variant and Variant Library Synthesis for CUX2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CUX2 for disorders           About GeneDecksing

OMIM gene information: 610648    OMIM disorders: --

5 diseases for CUX2:    About MalaCards

distal hereditary motor neuropathy fiedler's myocarditis myocarditis bipolar disorder

neuropathy

1 disease from the University of Copenhagen DISEASES database for CUX2:

fiedler's myocarditis

Human Genome Epidemiology (HuGE) Navigator: CUX2 (5 documents)

Export disorders for CUX2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CUX2 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with CUX2)

Utopia: connect your pdf to the dynamic
world of online information

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{1, 2} Nakajima D.... Nagase T. (2002)
Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. (PubMed id 9179496)^{1, 2} Ohara O....Nomura N. (1997)
CUX2, a potential regulator of NCAM expression: genomic characterization and analysis as a positional candidate susceptibility gene for bipolar disorder. (PubMed id 11353453)^{1, 9} Jacobsen N.J.O.... Owen M.J. (2001)
1000 Genomes-based imputation identifies novel and ref ined associations for the Wellcome Trust Case Control Consortium phase 1 Data. (PubMed id 22293688)¹ Huang J....Li Y. (2012)
Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)¹ Jugessur A....Murray J.C. (2010)
Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. (PubMed id 19328558)¹ Yosifova A....Nakamura Y. (2009)
High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PubMed id 19401682)¹ Maestrini E....Monaco A.P. (2009)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)
The finished DNA sequence of human chromosome 12. (PubMed id 16541075)² Scherer S.E.... Gibbs R.A. (2006)
Biochemical characterization of the mammalian Cux2 protein. (PubMed id 15656993)¹ Gingras H....Nepveu A. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23316	HGNC: 19347	AceView: CUTL2	Ensembl:ENSG00000111249	euGenes: HUgn23316
ECgene: CUX2	H-InvDB: CUX2

(According to HUGE)
About This Section

HUGE: KIAA0293

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CUX2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CUX2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CUX2 gene:
Search GeneIP for patents involving CUX2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUX2

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Search ThermoFisher Antibodies for CUX2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUX2

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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CUX2 Gene

cut-like homeobox 2

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CUX2 Gene

cut-like homeobox 2

Aliasesfor CUX2 gene

Summariesfor CUX2 gene

Genomic Viewsfor CUX2 gene

Proteinsfor CUX2 gene

Protein Domains /Familiesfor CUX2 gene

Functionfor CUX2 gene

Pathways & Interactionsfor CUX2 gene

Drugs & Compoundsfor CUX2 gene

Transcriptsfor CUX2 gene

Expression for CUX2 gene

Orthologsfor CUX2 gene

Paralogsfor CUX2 gene

Genomic Variantsfor CUX2 gene

Disorders / Diseasesfor CUX2 gene

Publicationsfor CUX2 gene

External Searches for CUX2 gene

Genome Databases showing CUX2 gene

Other Databases showing CUX2 gene

Specialized Databases showing CUX2 gene

Intellectual Propertyfor CUX2 gene

Productsfor CUX2 gene

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Aliases
for CUX2 gene

Summaries
for CUX2 gene

Genomic Views
for CUX2 gene

Proteins
for CUX2 gene

Protein Domains /
Families
for CUX2 gene

Function
for CUX2 gene

Pathways & Interactions
for CUX2 gene

Drugs & Compounds
for CUX2 gene

Transcripts
for CUX2 gene

Expression
for CUX2 gene

Orthologs
for CUX2 gene

Paralogs
for CUX2 gene

Genomic Variants
for CUX2 gene

Disorders / Diseases
for CUX2 gene

Publications
for CUX2 gene

Intellectual Property
for CUX2 gene

Products
for CUX2 gene