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Aliases for CUX2 Gene

Aliases for CUX2 Gene

  • Cut-Like Homeobox 2 2 3
  • Homeobox Protein Cux-2 3 4
  • CUTL2 3 4
  • Homeobox Protein Cut-Like 2 3
  • Cut-Like 2 (Drosophila) 2
  • KIAA0293 4
  • CDP2 3

External Ids for CUX2 Gene

Previous HGNC Symbols for CUX2 Gene

  • CUTL2

Previous GeneCards Identifiers for CUX2 Gene

  • GC12P109956
  • GC12P111471
  • GC12P108667

Summaries for CUX2 Gene

Entrez Gene Summary for CUX2 Gene

  • This gene encodes a protein which contains three CUT domains and a homeodomain; both domains are DNA-binding motifs. A similar gene, whose gene product possesses different DNA-binding activities, is located on chromosome on chromosome 7. Two pseudogenes of this gene have been identified on chromosomes 10 and 4. [provided by RefSeq, Jan 2013]

GeneCards Summary for CUX2 Gene

CUX2 (Cut-Like Homeobox 2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is ONECUT1.

UniProtKB/Swiss-Prot for CUX2 Gene

  • May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUX2 Gene

Genomics for CUX2 Gene

Regulatory Elements for CUX2 Gene

Genomic Location for CUX2 Gene

111,034,024 bp from pter
111,350,554 bp from pter
316,531 bases
Plus strand

Genomic View for CUX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CUX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUX2 Gene

Proteins for CUX2 Gene

  • Protein details for CUX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox protein cut-like 2
    Protein Accession:
    Secondary Accessions:
    • A7E2Y4

    Protein attributes for CUX2 Gene

    1486 amino acids
    Molecular mass:
    161677 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA22962.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CUX2 Gene

neXtProt entry for CUX2 Gene

Proteomics data for CUX2 Gene at MOPED

Post-translational modifications for CUX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CUX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CUX2 Gene

Domains for CUX2 Gene

Gene Families for CUX2 Gene

  • CUT :Homeoboxes / CUT class

Protein Domains for CUX2 Gene

Suggested Antigen Peptide Sequences for CUX2 Gene

Graphical View of Domain Structure for InterPro Entry



  • O14529
  • Contains 3 CUT DNA-binding domains.
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the CUT homeobox family.
genes like me logo Genes that share domains with CUX2: view

Function for CUX2 Gene

Molecular function for CUX2 Gene

UniProtKB/Swiss-Prot Function: May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity).

Gene Ontology (GO) - Molecular Function for CUX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISS --
GO:0003677 DNA binding --
GO:0043565 sequence-specific DNA binding IDA 15656993
genes like me logo Genes that share ontologies with CUX2: view
genes like me logo Genes that share phenotypes with CUX2: view

Animal Models for CUX2 Gene

MGI Knock Outs for CUX2:

miRNA for CUX2 Gene

miRTarBase miRNAs that target CUX2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CUX2 Gene

Localization for CUX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CUX2 Gene

Subcellular locations from

Jensen Localization Image for CUX2 Gene COMPARTMENTS Subcellular localization image for CUX2 gene
Compartment Confidence
nucleus 5
cytosol 4
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for CUX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15656993
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CUX2: view

Pathways for CUX2 Gene

SuperPathways for CUX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CUX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 15656993
GO:0006351 transcription, DNA-templated IEA --
GO:0007614 short-term memory ISS --
GO:0010628 positive regulation of gene expression ISS --
GO:0045892 negative regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with CUX2: view

No data available for Pathways by source for CUX2 Gene

Transcripts for CUX2 Gene

Unigene Clusters for CUX2 Gene

Cut-like homeobox 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CUX2 Gene

No ASD Table

Relevant External Links for CUX2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CUX2 Gene

mRNA expression in normal human tissues for CUX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CUX2 Gene

This gene is overexpressed in Liver (11.2), Brain - Cortex (9.4), Brain - Frontal Cortex (BA9) (8.1), and Brain - Anterior cingulate cortex (BA24) (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CUX2 Gene

SOURCE GeneReport for Unigene cluster for CUX2 Gene Hs.124953

genes like me logo Genes that share expressions with CUX2: view

No data available for mRNA Expression by UniProt/SwissProt for CUX2 Gene

Orthologs for CUX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CUX2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CUX2 35
  • 99.43 (n)
  • 99.41 (a)
CUX2 36
  • 99 (a)
(Bos Taurus)
Mammalia CUX2 35
  • 88.99 (n)
  • 91.49 (a)
CUX2 36
  • 92 (a)
(Canis familiaris)
Mammalia CUX2 35
  • 88.83 (n)
  • 92.52 (a)
CUX2 36
  • 91 (a)
(Mus musculus)
Mammalia Cux2 35
  • 81.45 (n)
  • 83.42 (a)
Cux2 16
Cux2 36
  • 83 (a)
(Monodelphis domestica)
Mammalia CUX2 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia CUX2 36
  • 77 (a)
(Rattus norvegicus)
Mammalia Cux2 35
  • 81.84 (n)
  • 82.93 (a)
(Gallus gallus)
Aves CUX2 35
  • 74.12 (n)
  • 74.54 (a)
CUX2 36
  • 73 (a)
(Anolis carolinensis)
Reptilia CUX2 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cux2 35
  • 64.08 (n)
  • 66.6 (a)
(Danio rerio)
Actinopterygii cux2 35
  • 64.28 (n)
  • 62.6 (a)
cux2b 36
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta ct 36
  • 17 (a)
(Caenorhabditis elegans)
Secernentea ceh-44 36
  • 24 (a)
Species with no ortholog for CUX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CUX2 Gene

Gene Tree for CUX2 (if available)
Gene Tree for CUX2 (if available)

Paralogs for CUX2 Gene

Paralogs for CUX2 Gene

Selected SIMAP similar genes for CUX2 Gene using alignment to 4 proteins: Pseudogenes for CUX2 Gene

genes like me logo Genes that share paralogs with CUX2: view

Variants for CUX2 Gene

Sequence variations from dbSNP and Humsavar for CUX2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs732166 -- 111,104,097(+) ACTAA(A/G)AGCCT intron-variant
rs732167 -- 111,104,161(-) TAAAA(A/G)AGATG intron-variant
rs739484 -- 111,192,715(+) GACCC(C/T)TGGAT intron-variant
rs739574 -- 111,104,805(-) CTTGG(G/T)GTTCC intron-variant
rs756825 -- 111,160,398(+) ctggg(C/T)gtatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CUX2 Gene

Variant ID Type Subtype PubMed ID
esv25829 CNV Loss 19812545
esv2659278 CNV Deletion 23128226
esv2665858 CNV Deletion 23128226
esv22627 CNV Loss 19812545
nsv832513 CNV Gain 17160897
esv2746357 CNV Deletion 23290073
esv2746358 CNV Deletion 23290073
nsv455714 CNV Loss 19166990
esv2667290 CNV Deletion 23128226
nsv513366 CNV Insertion 21212237

Relevant External Links for CUX2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CUX2 Gene

Disorders for CUX2 Gene

(1) University of Copenhagen DISEASES for CUX2 Gene

Relevant External Links for CUX2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CUX2: view

No data available for UniProtKB/Swiss-Prot for CUX2 Gene

Publications for CUX2 Gene

  1. CUX2, a potential regulator of NCAM expression: genomic characterization and analysis as a positional candidate susceptibility gene for bipolar disorder. (PMID: 11353453) Jacobsen N.J.O. … Owen M.J. (Am. J. Med. Genet. 2001) 3 23
  2. Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. (PMID: 9179496) Ohara O. … Nomura N. (DNA Res. 1997) 3 4
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  4. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. (PMID: 19328558) Yosifova A. … Nakamura Y. (J Affect Disord 2009) 3 48
  5. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PMID: 19401682) Maestrini E. … Monaco A.P. (Mol. Psychiatry 2010) 3 48

Products for CUX2 Gene

Sources for CUX2 Gene

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