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Aliases for CUX1 Gene

Aliases for CUX1 Gene

  • Cut Like Homeobox 1 2 3 5
  • Golgi Integral Membrane Protein 6 2 3
  • CCAAT Displacement Protein 3 4
  • Homeobox Protein Cux-1 3 4
  • CUTL1 3 4
  • CDP 3 4
  • Cut (Drosophila)-Like 1 (CCAAT Displacement Protein) 2
  • Cut-Like 1, CCAAT Displacement Protein (Drosophila) 2
  • Putative Protein Product Of Nbla10317 3
  • Cut-Like Homeobox 1 2
  • Protein CASP 3
  • Cut Homolog 3
  • Nbla10317 3
  • CDP/Cut 3
  • Cux/CDP 3
  • GOLIM6 3
  • P200 3
  • P100 3
  • CASP 3
  • CDP1 3
  • COY1 3
  • Clox 3
  • P110 3
  • CUX 3
  • P75 3

External Ids for CUX1 Gene

Previous HGNC Symbols for CUX1 Gene

  • CUTL1

Previous GeneCards Identifiers for CUX1 Gene

  • GC07P101247
  • GC07P101459
  • GC07P096049

Summaries for CUX1 Gene

Entrez Gene Summary for CUX1 Gene

  • The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011]

GeneCards Summary for CUX1 Gene

CUX1 (Cut Like Homeobox 1) is a Protein Coding gene. Diseases associated with CUX1 include Leiomyoma and Fiedler's Myocarditis. Among its related pathways are Vesicle-mediated transport and HIV Life Cycle. GO annotations related to this gene include sequence-specific DNA binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is CUX2.

UniProtKB/Swiss-Prot for CUX1 Gene

  • May be involved in intra-Golgi retrograde transport.

  • Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5 and 3) of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator (By similarity).

Gene Wiki entry for CUX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUX1 Gene

Genomics for CUX1 Gene

Regulatory Elements for CUX1 Gene

Enhancers for CUX1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F101853 1.8 FANTOM5 Ensembl ENCODE 21 +42.6 42649 9.5 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A FEZF1 ZNF2 YY1 CUX1 ENSG00000213385 SH2B2 UPK3BL PRKRIP1 RASA4B GC07P101859 ENSG00000259294
GH07F101985 2 Ensembl ENCODE 11.2 +170.2 170159 2.1 HDGF PKNOX1 EBF1 ZIC2 RAD21 ZNF121 ZFHX2 POLR2A SCRT2 CREM CUX1 RASA4DP UPK3BL GC07M101947 GC07M102004
GH07F101739 1.7 FANTOM5 Ensembl ENCODE 12.9 -73.8 -73821 5.8 PKNOX1 CREB3L1 SIN3A ARID4B FEZF1 DMAP1 ZNF2 ZNF143 FOS ZNF263 CUX1 CLDN15 GC07P101775 GC07M101683
GH07F101727 1.6 FANTOM5 Ensembl ENCODE 11.8 -86.8 -86830 2.7 HDGF SLC30A9 ZNF548 FOS JUNB ZHX2 REST SMARCB1 SMARCA4 GLIS1 PRKRIP1 CUX1 ALKBH4 GC07M101683 GC07P101775
GH07F102284 1.5 FANTOM5 ENCODE 12 +470.8 470819 5.4 ATF1 PKNOX1 ZNF133 ARID4B SIN3A GLI4 YBX1 ZNF48 ZNF2 YY1 SH2B2 CUX1 ORAI2 ENSG00000239486 POLR2J ARMC10 COL26A1 PRKRIP1 POLR2J3 ALKBH4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CUX1 on UCSC Golden Path with GeneCards custom track

Promoters for CUX1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001716308 97 4800 CREB3L1 SIN3A ZNF2 YY1 ZNF143 ZNF207 FOS REST SMARCB1 KAT8

Transcription factor binding sites by QIAGEN in the CUX1 gene promoter:

Genomic Location for CUX1 Gene

Chromosome:
7
Start:
101,815,904 bp from pter
End:
102,283,958 bp from pter
Size:
468,055 bases
Orientation:
Plus strand

Genomic View for CUX1 Gene

Genes around CUX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CUX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CUX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUX1 Gene

Proteins for CUX1 Gene

  • Protein details for CUX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P39880-CUX1_HUMAN
    Recommended name:
    Homeobox protein cut-like 1
    Protein Accession:
    P39880
    Secondary Accessions:
    • B3KV79
    • J3KQV9
    • Q6NYH4
    • Q75LE5
    • Q75MT2
    • Q75MT3
    • Q86UJ7
    • Q9UEV5

    Protein attributes for CUX1 Gene

    Size:
    1505 amino acids
    Molecular mass:
    164187 Da
    Quaternary structure:
    • Interacts with BANP. Interacts with SATB1 (via DNA-binding domains); the interaction inhibits the attachment of both proteins to DNA (By similarity).
    Miscellaneous:
    • Asn-1290 may participate in regulating DNA-binding activity by promoting homo- and heterodimerization.

    Alternative splice isoforms for CUX1 Gene

  • Protein details for CUX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13948-CASP_HUMAN
    Recommended name:
    Protein CASP
    Protein Accession:
    Q13948
    Secondary Accessions:
    • B3KWH3
    • B3KWH8
    • B4DZZ2
    • G3V1Z6
    • J3KPQ6
    • Q53GU9
    • Q8TBS3

    Protein attributes for CUX1 Gene

    Size:
    678 amino acids
    Molecular mass:
    77455 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with GOLGA5.

    Alternative splice isoforms for CUX1 Gene

neXtProt entry for CUX1 Gene

Post-translational modifications for CUX1 Gene

  • Ubiquitination at Lys 611
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CUX1 (CUTL1)

No data available for DME Specific Peptides for CUX1 Gene

Domains & Families for CUX1 Gene

Gene Families for CUX1 Gene

Suggested Antigen Peptide Sequences for CUX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P39880

UniProtKB/Swiss-Prot:

CASP_HUMAN :
  • Contains 3 CUT DNA-binding domains.
  • Belongs to the CASP family.
Domain:
  • Contains 3 CUT DNA-binding domains.
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the CASP family.
  • Belongs to the CUT homeobox family.
genes like me logo Genes that share domains with CUX1: view

Function for CUX1 Gene

Molecular function for CUX1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in intra-Golgi retrograde transport.
UniProtKB/Swiss-Prot Function:
Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5 and 3) of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator (By similarity).

Gene Ontology (GO) - Molecular Function for CUX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISS --
GO:0003677 DNA binding IEA --
GO:0004713 protein tyrosine kinase activity TAS --
GO:0030674 protein binding, bridging IEA --
GO:0043565 sequence-specific DNA binding IDA 15656993
genes like me logo Genes that share ontologies with CUX1: view
genes like me logo Genes that share phenotypes with CUX1: view

Animal Model Products

Transcription Factor Targets for CUX1 Gene

Selected GeneGlobe predicted Target genes for CUX1

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and HOMER Transcription for CUX1 Gene

Localization for CUX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CUX1 Gene

Nucleus.
Golgi apparatus membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CUX1 gene
Compartment Confidence
nucleus 5
cytosol 4
golgi apparatus 4
plasma membrane 1
extracellular 1
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CUX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IBA,TAS --
GO:0005634 nucleus IEA,IDA 15656993
GO:0005654 nucleoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CUX1: view

Pathways & Interactions for CUX1 Gene

genes like me logo Genes that share pathways with CUX1: view

Pathways by source for CUX1 Gene

SIGNOR curated interactions for CUX1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for CUX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 1301999
GO:0000301 retrograde transport, vesicle recycling within Golgi IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 1301999
genes like me logo Genes that share ontologies with CUX1: view

Drugs & Compounds for CUX1 Gene

(1) Drugs for CUX1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CUX1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CUX1: view

Transcripts for CUX1 Gene

Unigene Clusters for CUX1 Gene

Cut-like homeobox 1:
Representative Sequences:

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CUX1 Gene

No ASD Table

Relevant External Links for CUX1 Gene

GeneLoc Exon Structure for
CUX1
ECgene alternative splicing isoforms for
CUX1

Expression for CUX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CUX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CUX1 Gene

This gene is overexpressed in Bone (12.3), Peripheral blood mononuclear cells (11.3), and Pancreas (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CUX1 Gene



Protein tissue co-expression partners for CUX1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CUX1 Gene:

CUX1

SOURCE GeneReport for Unigene cluster for CUX1 Gene:

Hs.191482
genes like me logo Genes that share expression patterns with CUX1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CUX1 Gene

Orthologs for CUX1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CUX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CUX1 34 35
  • 98.37 (n)
oppossum
(Monodelphis domestica)
Mammalia CUX1 35
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CUX1 34 35
  • 89.17 (n)
mouse
(Mus musculus)
Mammalia Cux1 35
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CUX1 34 35
  • 88.72 (n)
rat
(Rattus norvegicus)
Mammalia Cux1 34
  • 86.03 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CUX1 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves CUX1 34 35
  • 80.77 (n)
lizard
(Anolis carolinensis)
Reptilia CUX1 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cux1 34
  • 72.66 (n)
zebrafish
(Danio rerio)
Actinopterygii cux1a 34 35
  • 67.99 (n)
idibd1033 34
fruit fly
(Drosophila melanogaster)
Insecta ct 35
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ceh-44 35
  • 25 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COY1 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.939 34
Species where no ortholog for CUX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CUX1 Gene

ENSEMBL:
Gene Tree for CUX1 (if available)
TreeFam:
Gene Tree for CUX1 (if available)

Paralogs for CUX1 Gene

Variants for CUX1 Gene

Sequence variations from dbSNP and Humsavar for CUX1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_036285 A breast cancer sample
VAR_036286 A colorectal cancer sample
rs10081174 -- 101,903,372(+) TGGGT(C/G)GGGGG intron-variant
rs10215335 -- 101,865,553(+) AAATG(A/G)CAAGG intron-variant
rs10215627 -- 102,151,707(+) tgggc(A/G)acaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CUX1 Gene

Variant ID Type Subtype PubMed ID
dgv11536n54 CNV loss 21841781
dgv11537n54 CNV loss 21841781
dgv11538n54 CNV loss 21841781
dgv11539n54 CNV loss 21841781
dgv6538n100 CNV gain 25217958
esv1633410 CNV insertion 17803354
esv24041 CNV gain 19812545
esv2664474 CNV deletion 23128226
esv2734942 CNV deletion 23290073
nsv1124252 CNV deletion 24896259
nsv1119135 CNV deletion 24896259
nsv1117747 CNV deletion 24896259
nsv1075986 CNV deletion 25765185
nsv1075985 CNV deletion 25765185
nsv1075048 CNV deletion 25765185
nsv1027574 CNV loss 25217958
nsv1020372 CNV gain 25217958
esv995309 CNV insertion 20482838
esv988391 CNV deletion 20482838
esv3614346 CNV loss 21293372
esv3614345 CNV loss 21293372
esv3614344 CNV loss 21293372
esv3614343 CNV loss 21293372
esv3614342 CNV loss 21293372
esv3542187 CNV deletion 23714750
esv3542186 CNV deletion 23714750
esv3448851 CNV insertion 20981092
esv3416476 CNV insertion 20981092
esv29675 CNV loss 19812545
esv2759548 CNV gain 17122850
esv2734943 CNV deletion 23290073
nsv831079 CNV loss 17160897
nsv824247 CNV gain 20364138
nsv824246 CNV gain 20364138
nsv824245 CNV gain 20364138
nsv824244 CNV gain 20364138
nsv824243 CNV gain 20364138
nsv821048 CNV deletion 20802225
nsv8189 CNV gain 18304495
nsv607995 CNV loss 21841781
nsv607991 CNV loss 21841781
nsv607985 CNV loss 21841781
nsv5878 CNV insertion 18451855
nsv526147 CNV loss 19592680
nsv521041 CNV loss 19592680
nsv510103 OTHER sequence alteration 20534489
nsv509218 CNV insertion 20534489
nsv508474 CNV deletion 20534489
nsv483094 CNV gain 15286789
nsv472415 CNV novel sequence insertion 20440878
nsv428182 CNV gain 18775914
nsv1132080 CNV deletion 24896259
nsv949918 CNV deletion 24416366
nsv949917 CNV deletion 24416366
nsv831082 CNV gain 17160897
nsv831080 CNV loss 17160897

Variation tolerance for CUX1 Gene

Residual Variation Intolerance Score: 2.32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.19; 51.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CUX1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CUX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CUX1 Gene

Disorders for CUX1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for CUX1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
leiomyoma
  • leiomyomatous neoplasm
fiedler's myocarditis
  • fiedler myocarditis
norrie disease
  • atrophia bulborum hereditaria
histidinemia
  • histidinuria
histidine metabolism disease
  • disturbances of histidine metabolism
- elite association - COSMIC cancer census association via MalaCards
Search CUX1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CUX1

Genetic Association Database (GAD)
CUX1
Human Genome Epidemiology (HuGE) Navigator
CUX1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CUX1
genes like me logo Genes that share disorders with CUX1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CUX1 Gene

Publications for CUX1 Gene

  1. Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. (PMID: 9799793) Gloeckner G. … Rosenthal A. (Genome Res. 1998) 2 3 4 22 64
  2. The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins. (PMID: 15004235) Oka T. … Krieger M. (Mol. Biol. Cell 2004) 2 3 22 64
  3. Exon/intron structure and alternative transcripts of the CUTL1 gene. (PMID: 10607901) Rong Zeng W. … Nepveu A. (Gene 2000) 3 4 22 64
  4. Regional localization of the CCAAT displacement protein gene (CUTL1) to 7q22 by analysis of somatic cell hybrids. (PMID: 8468066) Scherer S.W. … Tsui L.C. (Genomics 1993) 2 3 22 64
  5. Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut. (PMID: 1301999) Neufeld E.J. … Orkin S.H. (Nat. Genet. 1992) 3 4 22 64

Products for CUX1 Gene

Sources for CUX1 Gene

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