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CUX1 Gene

protein-coding   GIFtS: 60
GCID: GC07P101459

Cut-Like Homeobox 1

(Previous names: cut (Drosophila)-like 1 (CCAAT displacement protein), cut-like...)
(Previous symbol: CUTL1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cut-Like Homeobox 11 2     CUX2
CUTL11 2 3 5     Clox2
CDP2 3 5     Cux/CDP2
Golgi Integral Membrane Protein 61 2     GOLIM62
Homeobox Protein Cux-12 3     Nbla103172
CCAAT Displacement Protein2 3     Cut Homolog2
Cut (Drosophila)-Like 1 (CCAAT Displacement Protein)1     p1002
Cut-Like 1, CCAAT Displacement Protein (Drosophila)1     p1102
CASP2     p2002
CDP/Cut2     p752
CDP12     Protein CASP2
COY12     Putative Protein Product Of Nbla103172

External Ids:    HGNC: 25571   Entrez Gene: 15232   Ensembl: ENSG000002579237   OMIM: 1168965   UniProtKB: Q139483   
UniProtKB: P398803   

Export aliases for CUX1 gene to outside databases

Previous GC identifers: GC07P101247 GC07P096049


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CUX1 Gene:
The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate
gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession.
Several alternatively spliced transcript variants encoding different isoforms have been identified.(provided by
RefSeq, Feb 2011)

GeneCards Summary for CUX1 Gene:
CUX1 (cut-like homeobox 1) is a protein-coding gene. Diseases associated with CUX1 include vaginal discharge, and norrie disease. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CUX2.

UniProtKB/Swiss-Prot: CUX1_HUMAN, P39880
Function: Probably has a broad role in mammalian development as a repressor of developmentally regulated gene
expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr
repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer.
Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located
upstream of the TCR beta enhancer (By similarity)

Gene Wiki entry for CUX1 (CUTL1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CUX1 gene promoter:
         TBP   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 9): CUX1 promoter sequence
   Search Chromatin IP Primers for CUX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CUX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

CUX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CUX1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P101459:  view genomic region     (about GC identifiers)

Start:
101,458,959 bp from pter      End:
101,927,250 bp from pter
Size:
468,292 bases      Orientation:
plus strand

2 alternative locations:
Chr7+,NW_003571037 21,691-208,288      Chr7+,CRA_TCAG 100,817,571-101,284,708     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CASP_HUMAN, Q13948 (See protein sequence)
Recommended Name: Protein CASP  
Size: 678 amino acids; 77455 Da
Subunit: Homodimer; disulfide-linked. Interacts with GOLGA5
Secondary accessions: B3KWH3 B3KWH8 B4DZZ2 G3V1Z6 J3KPQ6 Q53GU9 Q8TBS3
Alternative splicing: 11 isoforms:  Q13948-1   P39880-9   P39880-1   P39880-2   P39880-3   P39880-4   P39880-5   P39880-6   
Q13948-2   Q13948-9   Q13948-10   (No experimental confirmation available)

UniProtKB/Swiss-Prot: CUX1_HUMAN, P39880 (See protein sequence)

Recommended Name: Homeobox protein cut-like 1  
Size: 1505 amino acids; 164187 Da
Subunit: Interacts with BANP (By similarity)
Miscellaneous: Asn-1290 may participate in regulating DNA-binding activity by promoting homo- and
heterodimerization
Secondary accessions: B3KV79 J3KQV9 Q6NYH4 Q75LE5 Q75MT2 Q75MT3 Q86UJ7 Q9UEV5
Alternative splicing: 11 isoforms:  P39880-1   P39880-2   P39880-3   P39880-4   P39880-5   P39880-6   P39880-9   Q13948-1   
Q13948-2   Q13948-9   Q13948-10   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CUX1: NX_P39880

Explore proteomics data for CUX1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys83, Lys206, Lys388, Lys611
  • Modification sites at PhosphoSitePlus

  • See CUX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001189472.1  NP_001189473.1  NP_001189474.1  NP_001189475.1  NP_001904.2  NP_852477.1  NP_853530.2  

    ENSEMBL proteins: 
     ENSP00000414091   ENSP00000292538   ENSP00000377410   ENSP00000449371   ENSP00000353401  
     ENSP00000409745   ENSP00000292535   ENSP00000446630   ENSP00000447373   ENSP00000450125  
     ENSP00000451558   ENSP00000453648  
    Reactome Protein details: P39880

    CUX1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CUX1
    OriGene Protein Over-expression Lysate for CUX1
    OriGene MassSpec for CUX1
    OriGene Custom Protein Services for CUX1
    GenScript Custom Purified and Recombinant Proteins Services for CUX1
    Novus Biologicals CUX1 Proteins
    Novus Biologicals CUX1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CUX1

    CUX1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CUX1
    R&D Systems Antibodies for CUX1 (CDP/CUTL1)
    OriGene Antibodies for CUX1
    OriGene Custom Antibody Services for CUX1
    Novus Biologicals CUX1 Antibodies
    Abcam antibodies for CUX1
    Cloud-Clone Corp. Antibodies for CUX1
    ThermoFisher Antibodies for CUX1
    LSBio Antibodies in human, mouse, rat for CUX1

    CUX1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CUX1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CUX1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CUX1
    Cloud-Clone Corp. CLIAs for CUX1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CUT: Homeoboxes / CUT class

    Selected InterPro protein domains (see all 6):
     IPR012955 CASP_C
     IPR010982 Lambda_DNA-bd_dom
     IPR003350 Hmoeo_CUT
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom

    Graphical View of Domain Structure for InterPro Entry Q13948
    Graphical View of Domain Structure for InterPro Entry P39880

    ProtoNet protein and cluster: Q13948

    1 Blocks protein domain: IPB012955 CASP

    UniProtKB/Swiss-Prot: CASP_HUMAN, Q13948
    Similarity: Belongs to the CASP family

    UniProtKB/Swiss-Prot: CUX1_HUMAN, P39880
    Similarity: Belongs to the CUT homeobox family
    Similarity: Contains 3 CUT DNA-binding domains
    Similarity: Contains 1 homeobox DNA-binding domain


    CUX1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CASP_HUMAN, Q13948
    Function: May be involved in intra-Golgi retrograde transport

         UniProtKB/Swiss-Prot: CUX1_HUMAN, P39880
    Function: Probably has a broad role in mammalian development as a repressor of developmentally regulated gene
    expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr
    repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer.
    Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located
    upstream of the TCR beta enhancer (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding ISS--
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0030674protein binding, bridging IEA--
         
    CUX1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CUX1:
     Synthetic lethal with Ras  Synthetic lethal with imatinib 

         14 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Cux1):
     adipose tissue  behavior/neurological  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  mortality/aging  nervous system  pigmentation 
     renal/urinary system  reproductive system  respiratory system  skeleton 

    CUX1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CUX1: Cux1tm1Ejn Cux1tm1Rhsc Cux1tm2Ejn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CUX1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CUX1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CUX1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CUX1

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for CUX1 (see all 1881):
    AAA1,  AACS,  ABCC4,  ABCC5,  ABCG5,  ABHD1,  ABHD12B,  ABLIM2,  ABO,  ABTB2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CUX1:
    hsa-mir-92a-3p (MIRT048935), hsa-mir-877-3p (MIRT036826), hsa-let-7b-5p (MIRT052342), hsa-mir-455-3p (MIRT037836), hsa-mir-18b-5p (MIRT042405), hsa-mir-155-5p (MIRT004087)

    Block miRNA regulation of human, mouse, rat CUX1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CUX1 (see all 303):
    hsa-miR-579 hsa-miR-26a-2* hsa-miR-520f hsa-miR-146a hsa-miR-1260b hsa-miR-605 hsa-miR-4275 hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmidCUX1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CUX1
    Predesigned siRNA for gene silencing in human, mouse, rat CUX1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CUX1

    Clone
    Products:
         
    OriGene clones in human, mouse for CUX1 (see all 18)
    OriGene ORF clones in mouse, rat for CUX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 7): CUX1 (NM_181552)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CUX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUX1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CUX1
    Browse ESI BIO Cell Lines and PureStem Progenitors for CUX1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUX1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CASP_HUMAN, Q13948: Golgi apparatus membrane; Single-pass type IV membrane protein
    CUX1_HUMAN, P39880: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    nucleus5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    CUX1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CUX1 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by FGFR1 mutants
    Signaling by FGFR1 mutants0.67
    Signaling by FGFR1 fusion mutants0.00
    Signaling by FGFR mutants0.67
    2Signaling by FGFR
    Signaling by FGFR in disease0.91
    3Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for CUX1
        Signaling by FGFR1 fusion mutants



    CUX1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CUX1: 
              Homeobox (HOX) Genes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CUX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CUX1 (P398802, 3 ENSP000002925354) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RB1P064002, ENSP000002671634MINT-13923 MINT-13924 MINT-13926 MINT-13925 STRING: ENSP00000267163
    RECQL5O947622, ENSP000003176364MINT-64665 STRING: ENSP00000317636
    BIN1O004992, ENSP000003167794MINT-64663 STRING: ENSP00000316779
    CA12O435702, ENSP000001786384MINT-64664 STRING: ENSP00000178638
    ELAC2Q9BQ522MINT-64666
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0000301retrograde transport, vesicle recycling within Golgi IEA--
    GO:0001822kidney development IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----

    CUX1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CUX1

    2 Novoseek inferred chemical compound relationships for CUX1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oligonucleotide 3.03 2 9874597 (1), 9886051 (1)
    lysine 0 1 15269344 (1)



    CUX1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CUX1 gene (7 alternative transcripts): 
    NM_001202543.1  NM_001202544.2  NM_001202545.2  NM_001202546.2  NM_001913.4  NM_181500.3  NM_181552.3  

    Unigene Cluster for CUX1:

    Cut-like homeobox 1
    Hs.191482  [show with all ESTs]
    Unigene Representative Sequence: NM_001202543
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000437600(uc003uyt.3 uc003uyu.3 uc011kkn.2 uc003uyw.3 uc003uyv.3)
    ENST00000497815 ENST00000292538 ENST00000607092 ENST00000393824 ENST00000547394
    ENST00000360264(uc003uys.4) ENST00000425244 ENST00000292535(uc003uyx.4)
    ENST00000549414 ENST00000550008 ENST00000546411 ENST00000556210 ENST00000558469
    ENST00000560541 ENST00000558836 ENST00000606749 ENST00000465461
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CUX1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CUX1 (see all 303):
    hsa-miR-579 hsa-miR-26a-2* hsa-miR-520f hsa-miR-146a hsa-miR-1260b hsa-miR-605 hsa-miR-4275 hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmidCUX1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CUX1
    Predesigned siRNA for gene silencing in human, mouse, rat CUX1
    Clone
    Products:
         
    OriGene clones in human, mouse for CUX1 (see all 18)
    OriGene ORF clones in mouse, rat for CUX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 7): CUX1 (NM_181552)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CUX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUX1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CUX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CUX1
      QuantiTect SYBR Green Assays in human, mouse, rat CUX1
      QuantiFast Probe-based Assays in human, mouse, rat CUX1

    Additional mRNA sequence: 

    AB075522.1 AK056307.1 AK122726.1 AK125097.1 AK222832.1 AK303151.1 BC007204.1 BC012323.1 
    BC025422.2 BC040199.1 BC045562.1 BC066592.1 CR627481.1 L12579.1 M74099.1 

    Selected DOTS entries (see all 37):

    DT.116333  DT.95220586  DT.100721744  DT.437458  DT.91869554  DT.453428  DT.121072815  DT.95319402 
    DT.100826575  DT.70100048  DT.121072790  DT.100689588  DT.121072573  DT.91903819  DT.121072722  DT.75199992 
    DT.97846611  DT.121072897  DT.40235691  DT.100826571  DT.100697426  DT.92441581  DT.92441587  DT.100000033 

    Selected AceView cDNA sequences (see all 274):

    CA425841 BM791595 AA634330 BP341902 BQ707600 BQ447797 BG325697 AA459850 
    AI246024 BU526537 BE046521 CB130895 BG681923 BX281204 BU176118 BM464887 
    BC066592 AU280050 BU680456 AU137819 AI566686 CD613350 NM_181500 AA599968 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CUX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTGGTCTG
    CUX1 Expression
    About this image


    CUX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Hair (Integumentary System)    fully expand to see all 4 entries
             Fetal Companion Cells Companion Layer
     
     Epithelial Cells
             Fetal Inner Root Sheath Cells Inner Root Sheath
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
    CUX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CUX1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.191482
        Pathway & Disease-focused RT2 Profiler PCR Array including CUX1: 
              Homeobox (HOX) Genes in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CUX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CUX1
    QuantiTect SYBR Green Assays in human, mouse, rat CUX1
    QuantiFast Probe-based Assays in human, mouse, rat CUX1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CUX1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cux15 cut-like homeobox 1   --   5 (75.96 cM) 136248135 
    chicken
    (Gallus gallus)
    Aves CUX11 cut-like homeobox 1 80.77(n)
    85.9(a)
      101749861  XM_004946481.1  XP_004946538.1 
    lizard
    (Anolis carolinensis)
    Reptilia CUX16
    cut-like homeobox 1
    78(a)
    1 ↔ 1
    GL343613.1(21643-286719)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cux11 cut-like homeobox 1 72.66(n)
    79(a)
      100488175  XM_002942265.2  XP_002942311.2 
    zebrafish
    (Danio rerio)
    Actinopterygii idibd10332 idibd1033 77.08(n)   338139  BG985437.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ct6
    cut
    17(a)
    1 → many
    X(7503181-7572892)
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-446
    Protein CEH-44, isoform a (ceh-44) mRNA, complete ...
    25(a)
    1 → many
    III(2530615-2546417) WBGene00000464


    ENSEMBL Gene Tree for CUX1 (if available)
    TreeFam Gene Tree for CUX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CUX1 gene
    CUX22  ONECUT12  ONECUT22  ONECUT32  
    Selected SIMAP similar genes for CUX1 using alignment to 4 protein entries:     CASP_HUMAN (see all proteins) (see all similar genes):
    CUTL1    Nbla10317    R11    RET    FGFR4    FGFR2
    CUX2    R12    CCDC6-RETa    CCDC6-RETc    FGFR1    KIF5B-RET(NM_020630)_K15
    KIF5B-RET(NM_020630)_K16    KIF5B-RET(NM_020630)_K22    KIF5B-RET(NM_020630)_K23    KIF5B-RET(NM_020630)_K24    KIF5B-RET(NM_020975)_K15    KIF5B-RET(NM_020975)_K16

    CUX1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CUX1 (see all 10129)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362854
    A breast cancer sample4--see VAR_0362852 S G mis40--------
    VAR_0362864
    A colorectal cancer sample4--see VAR_0362862 R C mis40--------
    rs725805031,2
    C--96050420(+) TCTCT-/TTTGTCT 7 -- int10--------
    rs1995011481,2
    C--96060098(+) AACTTG/TTTTTT 7 -- int10--------
    rs1444233431,2
    C--96216407(+) ATATA-/TATATG
            
    TGTGT
    7 -- int10--------
    rs20917781,2
    A--96230809(-) AGGCTA/GTGATG 7 -- int10--------
    rs673219251,2
    C--96245404(+) AAAAA-/AAAAAA 7 -- int11Minor allele frequency- A:0.50NA 2
    rs27070071,2
    C--96248591(-) ACCACC/TACACT 7 -- int11Minor allele frequency- T:0.50NA 2
    rs26857711,2
    C--96248627(+) CACCCG/ACCACT 7 -- int11Minor allele frequency- A:0.50NA 2
    rs26857721,2
    C--96248657(+) CACAGC/TAGCCT 7 -- int11Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for CUX1 (101458959 - 101708959 bp, first 250kb of CUX1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CUX1 (see all 31):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734942CNV Deletion23290073
    esv988391CNV Deletion20482838
    esv2664474CNV Deletion23128226
    esv2734943CNV Deletion23290073
    nsv821048CNV Deletion20802225
    nsv509218CNV Insertion20534489
    esv995309CNV Insertion20482838
    esv1633410CNV Insertion17803354
    nsv5878CNV Insertion18451855
    nsv888830CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CUX1
    DNA2.0 Custom Variant and Variant Library Synthesis for CUX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 116896    OMIM disorders: --

    Selected diseases for CUX1 (see all 29):    
    About MalaCards
    vaginal discharge    norrie disease    hereditary persistence of fetal hemoglobin    vaginitis
    leiomyoma    epididymitis    major depressive disorder    polycystic kidney disease
    kidney disease    autism spectrum disorder    brain cancer    labyrinthitis
    lung adenocarcinoma    ovarian cancer    inflammatory bowel disease    retinoblastoma
    cystic fibrosis    acute myeloid leukemia    lymphoblastic leukemia    myeloid leukemia


    CUX1 for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for CUX1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    uterine leiomyoma 49.6 7 9178912 (3), 9591780 (2), 12766905 (1)
    leiomyoma 32.7 2 9591780 (1), 10208423 (1)
    mammary tumor 29.6 6 9591780 (2), 17018605 (1), 10208423 (1)
    myeloid leukemia 24.9 4 7759529 (1), 17018605 (1)
    tumors 12.4 31 9178912 (3), 11169958 (3), 17369846 (3), 15950902 (2) (see all 13)
    breast cancer 1.56 5 10208423 (2), 12438259 (1), 15950902 (1), 17018605 (1)
    cancer 1.2 6 16357536 (2), 15950902 (1), 18787218 (1), 11403998 (1) (see all 5)
    ovarian cancer 0 1 11169958 (1)
    carcinoma 0 1 15950902 (1)

    Genetic Association Database (GAD): CUX1
    Human Genome Epidemiology (HuGE) Navigator: CUX1 (3 documents)

    Export disorders for CUX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CUX1 gene, integrated from 10 sources (see all 165):
    (articles sorted by number of sources associating them with CUX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. (PubMed id 9799793)1, 2, 3, 9 Gloeckner G.... Rosenthal A. (Genome Res. 1998)
    2. Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut. (PubMed id 1301999)1, 2, 9 Neufeld E.J.... Orkin S.H. (Nat. Genet. 1992)
    3. Exon/intron structure and alternative transcripts of the CUTL1 gene. (PubMed id 10607901)1, 2, 9 Rong Zeng W.... Nepveu A. (Gene 2000)
    4. Regional localization of the CCAAT displacement protein gene (CUTL1) to 7q22 by analysis of somatic cell hybrids. (PubMed id 8468066)1, 3, 9 Scherer S.W....Tsui L.C. (Genomics 1993)
    5. The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins. (PubMed id 15004235)1, 3, 9 Oka T....Krieger M. (Mol. Biol. Cell 2004)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. FGFR2 is associated with hair thickness in Asian populations. (PubMed id 19590514)1, 4 Fujimoto A....Ohashi J. (J. Hum. Genet. 2009)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1523 HGNC: 2557 AceView: CUTL1 Ensembl:ENSG00000257923 euGenes: HUgn1523
    ECgene: CUX1 H-InvDB: CUX1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CUX1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CUX1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CUX1 gene:
    Search GeneIP for patents involving CUX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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