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Aliases for CUTC Gene

Aliases for CUTC Gene

  • CutC Copper Transporter 2 3 5
  • CutC Copper Transporter Homolog (E. Coli) 2
  • Copper Homeostasis Protein CutC Homolog 3
  • CutC Copper Transporter Homolog 3
  • CGI-32 3

External Ids for CUTC Gene

Previous GeneCards Identifiers for CUTC Gene

  • GC10P101157
  • GC10P101481
  • GC10P095119

Summaries for CUTC Gene

Entrez Gene Summary for CUTC Gene

  • Members of the CUT family of copper transporters are associated with copper homeostasis and are involved in the uptake, storage, delivery, and efflux of copper (Gupta et al., 1995 [PubMed 7635807]; Li et al., 2005 [PubMed 16182249]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CUTC Gene

CUTC (CutC Copper Transporter) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. GO annotations related to this gene include copper ion binding.

UniProtKB/Swiss-Prot for CUTC Gene

  • May play a role in copper homeostasis. Can bind one Cu(1+) per subunit.

Gene Wiki entry for CUTC Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUTC Gene

Genomics for CUTC Gene

Regulatory Elements for CUTC Gene

Enhancers for CUTC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G099658 1.3 ENCODE dbSUPER 11.6 -41.5 -41475 5.8 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 FOS CUTC CHUK ENTPD7 EBAG9P1 ABCC2 CWF19L1 PIR56896
GH10G099617 1.4 ENCODE dbSUPER 10.2 -82.6 -82624 5.6 CREB3L1 ZFP64 DMAP1 FEZF1 YY1 ZNF263 SP3 NFYC TBX21 ZNF610 NKX2-3 CHUK CUTC ENTPD7 ABCC2 EBAG9P1 CWF19L1 ENSG00000260475 PIR55652 GC10M099612
GH10G099665 1.1 ENCODE dbSUPER 11.9 -35.4 -35403 2.9 PKNOX1 INSM2 TCF12 GATA2 ZNF366 FOS SP3 CEBPB TSHZ1 ZEB2 EBAG9P1 CUTC ENTPD7 CWF19L1 PIR56896
GH10G099550 1.2 ENCODE dbSUPER 9.7 -151.0 -151028 1.4 PKNOX1 INSM2 FEZF1 ZNF2 ZNF366 ZSCAN5C SCRT2 ZNF391 EGR2 ZNF263 LOC101927300 GOT1 CUTC NKX2-3 GC10P099610
GH10G099630 1 Ensembl ENCODE 11.4 -71.8 -71758 0.8 CTCF PKNOX1 ZNF384 RAD21 ZNF335 ZNF316 SMC3 NFE2 MAFK NFE2L2 ENSG00000229278 ENTPD7 CUTC EBAG9P1 LOC105378450 GC10M099623
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CUTC on UCSC Golden Path with GeneCards custom track

Genomic Location for CUTC Gene

Chromosome:
10
Start:
99,702,558 bp from pter
End:
99,756,137 bp from pter
Size:
53,580 bases
Orientation:
Plus strand

Genomic View for CUTC Gene

Genes around CUTC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CUTC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CUTC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUTC Gene

Proteins for CUTC Gene

  • Protein details for CUTC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTM9-CUTC_HUMAN
    Recommended name:
    Copper homeostasis protein cutC homolog
    Protein Accession:
    Q9NTM9
    Secondary Accessions:
    • Q5TCZ8
    • Q9Y321

    Protein attributes for CUTC Gene

    Size:
    273 amino acids
    Molecular mass:
    29341 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for CUTC Gene

neXtProt entry for CUTC Gene

Post-translational modifications for CUTC Gene

  • Ubiquitination at Lys269
  • Modification sites at PhosphoSitePlus

Other Protein References for CUTC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CUTC Gene

Domains & Families for CUTC Gene

Protein Domains for CUTC Gene

Suggested Antigen Peptide Sequences for CUTC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NTM9

UniProtKB/Swiss-Prot:

CUTC_HUMAN :
  • Belongs to the CutC family.
Family:
  • Belongs to the CutC family.
genes like me logo Genes that share domains with CUTC: view

No data available for Gene Families for CUTC Gene

Function for CUTC Gene

Molecular function for CUTC Gene

UniProtKB/Swiss-Prot Function:
May play a role in copper homeostasis. Can bind one Cu(1+) per subunit.

Gene Ontology (GO) - Molecular Function for CUTC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005507 copper ion binding NAS 16182249
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CUTC: view
genes like me logo Genes that share phenotypes with CUTC: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CUTC

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CUTC Gene

Localization for CUTC Gene

Subcellular locations from UniProtKB/Swiss-Prot for CUTC Gene

Cytoplasm. Nucleus. Note=The overexpressed protein is detected in the cytoplasm, and depending on the cell line, also in the nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CUTC gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CUTC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 16182249
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA,IDA 16182249
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with CUTC: view

Pathways & Interactions for CUTC Gene

genes like me logo Genes that share pathways with CUTC: view

Pathways by source for CUTC Gene

Gene Ontology (GO) - Biological Process for CUTC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006825 copper ion transport NAS 16182249
GO:0051262 protein tetramerization IPI 19878721
GO:0055070 copper ion homeostasis IEA,NAS 16182249
genes like me logo Genes that share ontologies with CUTC: view

No data available for SIGNOR curated interactions for CUTC Gene

Drugs & Compounds for CUTC Gene

(1) Drugs for CUTC Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved Pharma 181
genes like me logo Genes that share compounds with CUTC: view

Transcripts for CUTC Gene

Unigene Clusters for CUTC Gene

CutC copper transporter homolog (E. coli):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CUTC

Alternative Splicing Database (ASD) splice patterns (SP) for CUTC Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: - -
SP2: -
SP3: - - -
SP4: -
SP5:

Relevant External Links for CUTC Gene

GeneLoc Exon Structure for
CUTC
ECgene alternative splicing isoforms for
CUTC

Expression for CUTC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CUTC Gene

mRNA differential expression in normal tissues according to GTEx for CUTC Gene

This gene is overexpressed in Muscle - Skeletal (x9.5).

Protein differential expression in normal tissues from HIPED for CUTC Gene

This gene is overexpressed in Heart (11.0), Peripheral blood mononuclear cells (7.2), and Retina (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CUTC Gene



Protein tissue co-expression partners for CUTC Gene

NURSA nuclear receptor signaling pathways regulating expression of CUTC Gene:

CUTC

SOURCE GeneReport for Unigene cluster for CUTC Gene:

Hs.16606

mRNA Expression by UniProt/SwissProt for CUTC Gene:

Q9NTM9-CUTC_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for CUTC Gene

  • Muscle(4.5)
  • Lung(4.2)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with CUTC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CUTC Gene

Orthologs for CUTC Gene

This gene was present in the common ancestor of animals.

Orthologs for CUTC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CUTC 34 35
  • 99.51 (n)
dog
(Canis familiaris)
Mammalia CUTC 34 35
  • 92.19 (n)
cow
(Bos Taurus)
Mammalia CUTC 34 35
  • 91.7 (n)
rat
(Rattus norvegicus)
Mammalia Cutc 34
  • 88.3 (n)
mouse
(Mus musculus)
Mammalia Cutc 34 16 35
  • 87.45 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CUTC 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves CUTC 34 35
  • 72.42 (n)
lizard
(Anolis carolinensis)
Reptilia CUTC 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cutc 34
  • 71.85 (n)
Str.16776 34
zebrafish
(Danio rerio)
Actinopterygii cutc 34 35
  • 67.73 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6136 34 35
  • 50.75 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002402 34
  • 48.3 (n)
worm
(Caenorhabditis elegans)
Secernentea cutc-1 34 35
  • 50.21 (n)
Species where no ortholog for CUTC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CUTC Gene

ENSEMBL:
Gene Tree for CUTC (if available)
TreeFam:
Gene Tree for CUTC (if available)

Paralogs for CUTC Gene

No data available for Paralogs for CUTC Gene

Variants for CUTC Gene

Sequence variations from dbSNP and Humsavar for CUTC Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_036363 A breast cancer sample
rs141066870 Likely benign 99,731,967(+) GTGCT(C/G)TAGGC upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs2231675 Likely benign 99,732,484(-) ATCAC(C/T)ACTGA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs2281636 Likely benign 99,732,646(+) CCTCA(G/T)AACGG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs11595470 Uncertain significance 99,732,455(+) TCCCC(C/G)GGGCG intron-variant, upstream-variant-2KB, utr-variant-5-prime

Variation tolerance for CUTC Gene

Residual Variation Intolerance Score: 54.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CUTC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CUTC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CUTC Gene

Disorders for CUTC Gene

Relevant External Links for CUTC

Genetic Association Database (GAD)
CUTC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CUTC

No disorders were found for CUTC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CUTC Gene

Publications for CUTC Gene

  1. Crystal structure of human copper homeostasis protein CutC reveals a potential copper-binding site. (PMID: 19878721) Li Y. … Ding J. (J. Struct. Biol. 2010) 3 4 22 64
  2. Identification and characterization of a novel Cut family cDNA that encodes human copper transporter protein CutC. (PMID: 16182249) Li J. … Mao Y. (Biochem. Biophys. Res. Commun. 2005) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4 64

Products for CUTC Gene

  • Addgene plasmids for CUTC

Sources for CUTC Gene

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