CUTC Gene
protein-coding GIFtS: 50
GCID: GC10P101481
|
|
cutC copper transporter homolog (E. coli)
| |
Aliases
for CUTC gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CutC Copper Transporter Homolog (E. Coli)1 2 | | CGI-321 | | RP11-483F11.32 | | Copper Homeostasis Protein CutC Homolog2 |
Export aliases for CUTC gene to outside databasesPrevious GC identifers: GC10P101157 GC10P095119 |
Summaries
for CUTC gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CUTC:
Members of the CUT family of copper transporters are associated with copper homeostasis and are involved in the uptake,storage, delivery, and efflux of copper (Gupta et al., 1995 (PubMed 7635807); Li et al., 2005 (PubMed16182249)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: CUTC_HUMAN, Q9NTM9Function: May play a role in copper homeostasis. Can bind one Cu(1+) per subunit
Gene Wiki entry for CUTC
|
Genomic Views
for CUTC gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CUTC gene promoter:
AREB6 STAT1 Lmo2 STAT1beta ZID STAT1alpha GATA-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CUTC
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CUTC |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q24.2 Ensembl cytogenetic band: 10q24.2 HGNC cytogenetic band: 10q24.31CUTC Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P101481: view genomic region
(about GC identifiers)
Start:
|
101,462,315 bp from pter |
End:
|
101,515,894 bp from pter |
Size:
|
53,580 bases |
Orientation:
|
plus strand |
|
Proteins
for CUTC gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CUTC_HUMAN, Q9NTM9 (See
protein sequence)Recommended Name: Copper homeostasis protein cutC homolog Size: 273 amino acids; 29341 Da
Subunit: Homotetramer
Subcellular location: Cytoplasm. Nucleus. Note=The overexpressed protein is detected in the cytoplasm, and depending onthe cell line, also in the nucleus
1 PDB 3D structure from  and Proteopedia  for CUTC:3IWP (3D)
Secondary accessions: Q5TCZ8 Q9Y321Explore the universe of human proteins at neXtProt for CUTC: NX_Q9NTM9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NTM9
CUTC Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057044.2
ENSEMBL proteins: ENSP00000359507 ENSP00000433900 ENSP00000359503
Human Recombinant Protein Products for CUTC:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
CUTC for ontologies About GeneDecksing
CUTC Antibody Products:
Assay Products for CUTC: |
Protein
Domains /
Families
for CUTC gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CUTC for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NTM9ProtoNet protein and cluster: Q9NTM9 UniProtKB/Swiss-Prot: CUTC_HUMAN, Q9NTM9Similarity: Belongs to the CutC family |
Function
for CUTC gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CUTC_HUMAN, Q9NTM9Function: May play a role in copper homeostasis. Can bind one Cu(1+) per subunit Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
CUTC for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CUTC (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CUTC
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CUTC (NM_015960) | |  | Sino Biological Human cDNA Clone for CUTC | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CUTC | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUTC |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUTC |
|
Pathways & Interactions
for CUTC gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CUTC
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/11 Interacting proteins for CUTC (Q9NTM92, 3 ENSP000003595074) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
CUTC for ontologies About GeneDecksing
|
Drugs & Compounds
for CUTC gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CUTC
1 HMDB Compound for CUTC About this table
Search CenterWatch for drugs/clinical trials and news about CUTC
|
Transcripts
for CUTC gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CUTC gene: NM_015960.2 Unigene Cluster for CUTC: CutC copper transporter homolog (E. coli) Hs.16606 [show with all ESTs]Unigene Representative Sequence: AK1304354 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000493385 ENST00000370476(uc010qpk.2 uc001kqd.4 uc001kqe.4)
ENST00000471520 ENST00000370472
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CUTC (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CUTC
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CUTC (NM_015960) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CUTC | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUTC |
Additional cDNA sequence: AF132966.1 AK001142.1 AK130435.1 AK302507.1 AK314687.1 BC011016.1 BC021105.1 BC028948.1 13 DOTS entries: DT.115401 DT.100815732 DT.100815731 DT.115400 DT.100036282 DT.121234346 DT.40131098 DT.95176903 DT.97775068 DT.121234368 DT.91902426 DT.92066261 DT.121234387 24/247 AceView cDNA sequences (see all 247): BM766670 BM679308 BM677773 AA181536 BM972169 AA316209 AK001142 CA306257 BI828517 AW613810 CA418375 NM_020354 BP346841 BX476961 BU619528 AI624722 BM668353 BM979941 BU619746 CR613820 CA488811 CA432699 BC021105 CA842068
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for CUTC About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CUTC
|
Expression
for CUTC gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CUTC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTATGAATTC
About this image
See CUTC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CUTC
SOURCE GeneReport for Unigene cluster: Hs.16606
UniProtKB/Swiss-Prot: CUTC_HUMAN, Q9NTM9Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for CUTC
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CUTC
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CUTC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CUTC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CUTC | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUTC |
Orthologs
for CUTC gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for CUTC gene from 8/21 species (see all 21) About this table
ENSEMBL Gene Tree for CUTC (if available)
TreeFam Gene Tree for CUTC (if available) |
Paralogs
for CUTC gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CUTC gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CUTC (101462315 - 101515894 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CUTC: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CUTC |
|
Disorders
/ Diseases
for CUTC gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CUTC for disorders About GeneDecksing
OMIM gene information: 610101
OMIM disorders: --
1  disease for CUTC: About MalaCardspneumonia
Export disorders for CUTC gene to outside databases
|
Publications
for CUTC gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CUTC gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with CUTC) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of a novel Cut family cDNA that encodes human copper transporter protein CutC. (PubMed id 16182249)1, 2, 3 Li J....Mao Y. (2005)
- Crystal structure of human copper homeostasis protein CutC reveals a potential copper-binding site. (PubMed id 19878721)1, 2, 9 Li Y....Ding J. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
- A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)1 Kenny E.E....Peter I. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for CUTC gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CUTC gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CUTC gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CUTC gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CUTC | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CUTC gene:
Search GeneIP for patents involving CUTC
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CUTC gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for CUTC | | OriGene shRNA RFP for CUTC | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CUTC | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CUTC | | | OriGene Protein Over-expression Lysate for CUTC | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CUTC | | OriGene 3'-UTR Clone for CUTC | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CUTC | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CUTC | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CUTC | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CUTC | | OriGene Custom Protein Services for CUTC | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CUTC | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CUTC | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CUTC | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CUTC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CUTC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CUTC |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CUTC |
| |  |  |  |  | | | | | | Recombinant Protein for CUTC |
|
 |
 |
 |
 | | | CUTC Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUTC |
|  |  |  |  | | | | Search ThermoFisher Antibodies for CUTC |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUTC |
| |  | |
|
|
|
