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CUTA Gene

protein-coding   GIFtS: 52
GCID: GC06M033384

CutA Divalent Cation Tolerance Homolog (E. Coli)

(Previous names: chromosome 6 open reading frame 82, acetylcholinesterase-associated...)
(Previous symbols: C6orf82, ACHAP)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CutA Divalent Cation Tolerance Homolog (E. Coli)1 2     Brain Acetylcholinesterase Putative Membrane Anchor2 3
Acetylcholinesterase-Associated Protein1 2 3     Chromosome 6 Open Reading Frame 821
ACHAP1 2 3     Divalent Cation Tolerant Protein CUTA2
C6orf821 2 3     Protein CutA2

External Ids:    HGNC: 211011   Entrez Gene: 515962   Ensembl: ENSG000001125147   UniProtKB: O608883   

Export aliases for CUTA gene to outside databases

Previous GC identifers: GC06M033493 GC06M033126


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CUTA Gene:
CUTA (cutA divalent cation tolerance homolog (E. coli)) is a protein-coding gene. Diseases associated with CUTA include intrahepatic cholangiocarcinoma, and cholangiocarcinoma. GO annotations related to this gene include enzyme binding.

UniProtKB/Swiss-Prot: CUTA_HUMAN, O60888
Function: May form part of a complex of membrane proteins attached to acetylcholinesterase (AChE)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NT_167249.2  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CUTA gene promoter:
         E2F-5   E2F   E2F-1   AP-1   ATF-2   E2F-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCUTA promoter sequence
   Search Chromatin IP Primers for CUTA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CUTA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.32   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.32

CUTA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CUTA gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M033384:  view genomic region     (about GC identifiers)

Start:
33,384,219 bp from pter      End:
33,386,094 bp from pter
Size:
1,876 bases      Orientation:
minus strand

1 alternative location:
Chr6-,NT_167249 4,864,565-4,866,311     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CUTA_HUMAN, O60888 (See protein sequence)
Recommended Name: Protein CutA precursor  
Size: 179 amino acids; 19116 Da
Subunit: Homotrimer
Sequence caution: Sequence=AAF61220.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for CUTA:
1XK8 (3D)        2ZFH (3D)    
Secondary accessions: A2AB26 A2BEL4 Q3B784 Q5JXM9 Q5SU05 Q9NYQ9
Alternative splicing: 3 isoforms:  O60888-1   O60888-2   O60888-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CUTA: NX_O60888

Explore proteomics data for CUTA at MOPED

Post-translational modifications: 

  • O-glycosylated1
  • Glycosylation2 at Thr168, Thr176
  • Modification sites at PhosphoSitePlus

  • See CUTA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001014433.1  NP_001014837.1  NP_001014838.1  NP_001014840.1  NP_057005.1  

    ENSEMBL proteins: 
     ENSP00000363624   ENSP00000417544   ENSP00000475963   ENSP00000418659   ENSP00000418612  
     ENSP00000417823   ENSP00000363608   ENSP00000403268   ENSP00000363620  

    CUTA Human Recombinant Protein Products:

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    ProSpec Recombinant Protein for CUTA
    Browse Proteins at Cloud-Clone Corp.

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR004323 Ion_tolerance_CutA
     IPR011322 N-reg_PII-like_a/b

    Graphical View of Domain Structure for InterPro Entry O60888

    ProtoNet protein and cluster: O60888

    UniProtKB/Swiss-Prot: CUTA_HUMAN, O60888
    Similarity: Belongs to the CutA family


    CUTA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CUTA_HUMAN, O60888
    Function: May form part of a complex of membrane proteins attached to acetylcholinesterase (AChE)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0019899enzyme binding IPI10800960
         
    CUTA for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CUTA:
     Elongated cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CUTA
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CUTA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CUTA

    miRNA
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    miRTarBase miRNAs that target CUTA:
    hsa-mir-484 (MIRT041685), hsa-mir-155-5p (MIRT020652)

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUTA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    extracellular1
    lysosome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane IDA10800960
    GO:0070062extracellular vesicular exosome IDA19056867

    CUTA for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CUTA
    Interactions:

        Search GeneGlobe Interaction Network for CUTA

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for CUTA (O608881, 3 ENSP000003636244) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR4A1P227361, 3EBI-1051556,EBI-721550 I2D: score=1 
    GRB2P629933, ENSP000003390074I2D: score=2 STRING: ENSP00000339007
    MCCP235083I2D: score=1 
    MLH1P406923I2D: score=1 
    PINX1Q96BK53I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008104protein localization IDA10800960
    GO:0010038response to metal ion IEA--

    CUTA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CUTA



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CUTA gene (5 alternative transcripts): 
    NM_001014433.2  NM_001014837.1  NM_001014838.1  NM_001014840.1  NM_015921.2  

    Unigene Cluster for CUTA:

    CutA divalent cation tolerance homolog (E. coli)
    Hs.520070  [show with all ESTs]
    Unigene Representative Sequence: BM913222
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000462802 ENST00000374500(uc003oen.1) ENST00000479249 ENST00000488034
    ENST00000607266 ENST00000494751 ENST00000488478 ENST00000482684 ENST00000374484
    ENST00000465956 ENST00000440279(uc003oej.1 uc003oem.1 uc003oek.1 uc003oel.1)
    ENST00000487637 ENST00000374496 ENST00000492510
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat CUTA
      QuantiFast Probe-based Assays in human, mouse, rat CUTA

    Additional mRNA sequence: 

    AF106943.1 AF230924.1 AK311556.1 BC005890.2 BC107751.1 

    19 DOTS entries:

    DT.100823864  DT.80101365  DT.95294758  DT.97855893  DT.92448614  DT.100722977  DT.92448612  DT.100715447 
    DT.92414190  DT.95364357  DT.100823865  DT.100823856  DT.92448596  DT.92448603  DT.100823861  DT.92448604 
    DT.121319942  DT.95364351  DT.92354396 

    Selected AceView cDNA sequences (see all 444):

    CB130698 AA620804 AL533788 AL038996 BI821481 BQ679689 AA743813 CR606293 
    CA748683 AI096824 BU069220 CR613274 CR595524 BU158743 W70287 BU662026 
    AI245618 BM706906 BU785543 AV693096 AA468809 AV696419 AI027189 BM988425 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CUTA (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e
    SP1:                    -     -     -     -                 -                                                   
    SP2:                    -     -     -     -                 -                                                   
    SP3:                                -     -                 -                                                   
    SP4:                                      -                 -                                                   
    SP5:                                                        -                                                   


    ECgene alternative splicing isoforms for CUTA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CUTA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGATCCCCG
    CUTA Expression
    About this image


    CUTA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    CUTA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CUTA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.520070

    UniProtKB/Swiss-Prot: CUTA_HUMAN, O60888
    Tissue specificity: Ubiquitous. Widely expressed in brain

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CUTA gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cuta1 , 5 cutA divalent cation tolerance homolog (E. coli)1, 5 87.01(n)1
    90.4(a)1
      17 (13.60 cM)5
    676751  NM_026307.31  NP_080583.31 
     269379735 
    chicken
    (Gallus gallus)
    Aves CUTA6
    cutA divalent cation tolerance homolog (E. coli)
    33(a)
    1 ↔ 1
    17(8281401-8286435)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.89742 Transcribed sequence with moderate similarity to protein more 71.53(n)    CF782916.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.101502 Transcribed sequence with weak similarity to protein more 75.1(n)    57091244 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG115906
    --
    32(a)
    1 ↔ 1
    X(14094211-14094940)
    worm
    (Caenorhabditis elegans)
    Secernentea F35G12.76
    Protein F35G12.7 (F35G12.7) mRNA, complete cds
    37(a)
    1 ↔ 1
    III(4586468-4587315) WBGene00009443


    ENSEMBL Gene Tree for CUTA (if available)
    TreeFam Gene Tree for CUTA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CUTA (see all 49)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1912350291,2
    --33384043(+) CTCTAC/TCCTCC 5 -- ds50010--------
    rs1158944281,2
    F--33384061(+) TTCCTG/CACCCC 5 -- ds50011Minor allele frequency- C:0.05WA 118
    rs1837735101,2
    --33384309(+) AAAAAA/CCAGGC 5 -- ds50010--------
    rs1884542551,2
    --33384333(+) ACCCAA/GAGACG 5 -- ut310--------
    rs1813018851,2
    --33384638(+) GACTGC/TCCAGC 5 -- int10--------
    rs1145405731,2
    C,F--33384734(+) ACTTTG/TGGTTT 10 K Q mis11Minor allele frequency- T:0.00NA 4552
    rs2012681501,2
    --33384746(+) AATCAC/TCTAAG 10 M V mis10--------
    rs2008392291,2
    --33384755(+) AGGGAC/TAAAGA 5 -- int10--------
    rs734023031,2
    C--33385006(+) GTTAAC/TCCCCC 5 -- int13Minor allele frequency- T:0.33WA CSA 122
    rs2003763941,2
    --33385076(+) GCTTCA/TCCACC 10 E V mis10--------

    HapMap Linkage Disequilibrium report for CUTA (33384219 - 33386094 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CUTA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv885769CNV Loss21882294
    nsv830637CNV Loss17160897
    nsv830635CNV Loss17160897

    Human Gene Mutation Database (HGMD): CUTA
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CUTA
    DNA2.0 Custom Variant and Variant Library Synthesis for CUTA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    5 diseases for CUTA:    
    About MalaCards
    intrahepatic cholangiocarcinoma    cholangiocarcinoma    systemic lupus erythematosus    lupus erythematosus
    malaria


    CUTA for disorders           About GeneDecksing

    Genetic Association Database (GAD): CUTA
    Human Genome Epidemiology (HuGE) Navigator: CUTA (2 documents)

    Export disorders for CUTA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CUTA gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with CUTA)
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    1. Two distinct proteins are associated with tetrameric acetylcholinesterase on the cell surface. (PubMed id 10954708)1, 2, 9 Perrier A.L.... Krejci E. (J. Biol. Chem. 2000)
    2. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. Hydrophobic protein that copurifies with human brain acetylcholinesterase: amino acid sequence, genomic organization, and chromosomal localization. (PubMed id 10800960)1, 2 Navaratnam D.S.... Smith A.D. (J. Neurochem. 2000)
    6. Characterization of the human CUTA isoform2 present in the stably transfected HeLa cells. (PubMed id 17924204)1, 9 Yang J....Yu L. (Mol. Biol. Rep. 2009)
    7. LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins. (PubMed id 23234360)2 Halim A.... Nilsson J. (J. Proteome Res. 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. CutA divalent cation tolerance homolog (Escherichia coli) (CUTA) regulates I^-cleavage of I^-amyloid precursor protein (APP) through interacting with I^-site APP cleaving protein 1 (BACE1). (PubMed id 22351782)1 Zhao Y....Zhang Y.W. (J. Biol. Chem. 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51596 HGNC: 21101 AceView: C6orf82 Ensembl:ENSG00000112514 euGenes: HUgn51596
    ECgene: CUTA H-InvDB: CUTA

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CUTA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CUTA gene:
    Search GeneIP for patents involving CUTA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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