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Aliases for CUTA Gene

Aliases for CUTA Gene

  • CutA Divalent Cation Tolerance Homolog (E. Coli) 2 3
  • Acetylcholinesterase-Associated Protein 2 3 4
  • Brain Acetylcholinesterase Putative Membrane Anchor 3 4
  • C6orf82 3 4
  • ACHAP 3 4
  • Divalent Cation Tolerant Protein CUTA 3
  • Chromosome 6 Open Reading Frame 82 2
  • Protein CutA 3

External Ids for CUTA Gene

Previous HGNC Symbols for CUTA Gene

  • C6orf82
  • ACHAP

Previous GeneCards Identifiers for CUTA Gene

  • GC06M033493
  • GC06M033126

Summaries for CUTA Gene

GeneCards Summary for CUTA Gene

CUTA (CutA Divalent Cation Tolerance Homolog (E. Coli)) is a Protein Coding gene. GO annotations related to this gene include enzyme binding.

UniProtKB/Swiss-Prot for CUTA Gene

  • May form part of a complex of membrane proteins attached to acetylcholinesterase (AChE)

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUTA Gene

Genomics for CUTA Gene

Regulatory Elements for CUTA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CUTA Gene

Start:
33,416,442 bp from pter
End:
33,418,317 bp from pter
Size:
1,876 bases
Orientation:
Minus strand

Genomic View for CUTA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CUTA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUTA Gene

Proteins for CUTA Gene

  • Protein details for CUTA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60888-CUTA_HUMAN
    Recommended name:
    Protein CutA
    Protein Accession:
    O60888
    Secondary Accessions:
    • A2AB26
    • A2BEL4
    • Q3B784
    • Q5JXM9
    • Q5SU05
    • Q9NYQ9

    Protein attributes for CUTA Gene

    Size:
    179 amino acids
    Molecular mass:
    19116 Da
    Quaternary structure:
    • Homotrimer
    SequenceCaution:
    • Sequence=AAF61220.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CUTA Gene

    Alternative splice isoforms for CUTA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CUTA Gene

Proteomics data for CUTA Gene at MOPED

Post-translational modifications for CUTA Gene

Antibody Products

No data available for DME Specific Peptides for CUTA Gene

Domains for CUTA Gene

Protein Domains for CUTA Gene

Suggested Antigen Peptide Sequences for CUTA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60888

UniProtKB/Swiss-Prot:

CUTA_HUMAN :
  • O60888
Family:
  • Belongs to the CutA family.
genes like me logo Genes that share domains with CUTA: view

No data available for Gene Families for CUTA Gene

Function for CUTA Gene

Molecular function for CUTA Gene

UniProtKB/Swiss-Prot Function:
May form part of a complex of membrane proteins attached to acetylcholinesterase (AChE)

Gene Ontology (GO) - Molecular Function for CUTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20195357
GO:0019899 enzyme binding IPI 10800960
genes like me logo Genes that share ontologies with CUTA: view

Phenotypes for CUTA Gene

GenomeRNAi human phenotypes for CUTA:
genes like me logo Genes that share phenotypes with CUTA: view

Animal Model Products

miRNA for CUTA Gene

miRTarBase miRNAs that target CUTA

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CUTA

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CUTA Gene

Localization for CUTA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CUTA Gene COMPARTMENTS Subcellular localization image for CUTA gene
Compartment Confidence
mitochondrion 2
extracellular 1
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CUTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 10800960
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CUTA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CUTA Gene

Pathways for CUTA Gene

SuperPathways for CUTA Gene

No Data Available

Interacting Proteins for CUTA Gene

Gene Ontology (GO) - Biological Process for CUTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008104 protein localization IDA 10800960
GO:0010038 response to metal ion IEA --
genes like me logo Genes that share ontologies with CUTA: view

No data available for Pathways by source for CUTA Gene

Transcripts for CUTA Gene

Unigene Clusters for CUTA Gene

CutA divalent cation tolerance homolog (E. coli):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CUTA

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CUTA Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: -
SP6: - -
SP7: - -
SP8:
SP9:

Relevant External Links for CUTA Gene

GeneLoc Exon Structure for
CUTA
ECgene alternative splicing isoforms for
CUTA

Expression for CUTA Gene

mRNA expression in normal human tissues for CUTA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CUTA Gene

SOURCE GeneReport for Unigene cluster for CUTA Gene Hs.520070

mRNA Expression by UniProt/SwissProt for CUTA Gene

O60888-CUTA_HUMAN
Tissue specificity: Ubiquitous. Widely expressed in brain.
genes like me logo Genes that share expressions with CUTA: view

Expression partners for CUTA Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for CUTA Gene

Orthologs for CUTA Gene

This gene was present in the common ancestor of animals.

Orthologs for CUTA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CUTA 35
  • 88.89 (n)
  • 92.67 (a)
CUTA 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CUTA 35
  • 88.14 (n)
  • 87.57 (a)
CUTA 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cuta 35
  • 87.01 (n)
  • 90.4 (a)
Cuta 16
Cuta 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CUTA 35
  • 99.44 (n)
  • 98.88 (a)
CUTA 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cuta 35
  • 85.12 (n)
  • 89.27 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 69 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CUTA 36
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves CUTA 36
  • 33 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cuta 35
  • 66.67 (n)
  • 73.87 (a)
Str.8974 35
zebrafish
(Danio rerio)
Actinopterygii Dr.10150 35
LOC100535353 35
  • 68.63 (n)
  • 68.24 (a)
CUTA 36
  • 61 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10007 35
fruit fly
(Drosophila melanogaster)
Insecta CG11590 36
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F35G12.7 36
  • 37 (a)
OneToOne
Species with no ortholog for CUTA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CUTA Gene

ENSEMBL:
Gene Tree for CUTA (if available)
TreeFam:
Gene Tree for CUTA (if available)

Paralogs for CUTA Gene

No data available for Paralogs for CUTA Gene

Variants for CUTA Gene

Sequence variations from dbSNP and Humsavar for CUTA Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1053841 -- 33,418,004(-) GTAGG(A/C/T)CGCAT intron-variant, utr-variant-5-prime
rs11543059 -- 33,417,549(-) GGCTA(C/G)GTTCC reference, stop-gained
rs28733686 -- 33,418,025(+) GAGAG(G/T)TGATC intron-variant, utr-variant-5-prime
rs62407905 -- 33,418,066(+) CCCCA(C/G)GAAGA intron-variant, utr-variant-5-prime
rs73402303 -- 33,417,229(+) GTTAA(C/T)CCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CUTA Gene

Variant ID Type Subtype PubMed ID
nsv830635 CNV Loss 17160897
nsv830637 CNV Loss 17160897
nsv885769 CNV Loss 21882294

Relevant External Links for CUTA Gene

HapMap Linkage Disequilibrium report
CUTA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CUTA Gene

Disorders for CUTA Gene

Relevant External Links for CUTA

Genetic Association Database (GAD)
CUTA
Human Genome Epidemiology (HuGE) Navigator
CUTA

No disorders were found for CUTA Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CUTA Gene

Publications for CUTA Gene

  1. Two distinct proteins are associated with tetrameric acetylcholinesterase on the cell surface. (PMID: 10954708) Perrier A.L. … Krejci E. (J. Biol. Chem. 2000) 3 4 23
  2. Characterization of the human CUTA isoform2 present in the stably transfected HeLa cells. (PMID: 17924204) Yang J. … Yu L. (Mol. Biol. Rep. 2009) 3 23
  3. Hydrophobic protein that copurifies with human brain acetylcholinesterase: amino acid sequence, genomic organization, and chromosomal localization. (PMID: 10800960) Navaratnam D.S. … Smith A.D. (J. Neurochem. 2000) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 48

Products for CUTA Gene

Sources for CUTA Gene

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