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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CUTA Gene

protein-coding   GIFtS: 48
GCID: GC06M033384

cutA divalent cation tolerance homolog (E. coli)

(Previous names: chromosome 6 open reading frame 82, acetylcholinesterase-associated...)
(Previous symbols: C6orf82, ACHAP)
 Explore 5 diseases affiliated with
CUTA via our new
 Human Malady Compendium 
Biological research products
for CUTA
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
CutA Divalent Cation Tolerance Homolog (E. Coli)1 2     Brain Acetylcholinesterase Putative Membrane Anchor2 3
Acetylcholinesterase-Associated Protein1 2 3     Chromosome 6 Open Reading Frame 821
ACHAP1 2 3     Divalent Cation Tolerant Protein CUTA2
C6orf821 2 3     Protein CutA2

External Ids:    HGNC: 211011   Entrez Gene: 515962   Ensembl: ENSG000001125147   UniProtKB: O608883   

Export aliases for CUTA gene to outside databases

Previous GC identifers: GC06M033493 GC06M033126


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CUTA_HUMAN, O60888
Function: May form part of a complex of membrane proteins attached to acetylcholinesterase (AChE)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CUTA gene promoter:
         E2F-5   E2F   E2F-1   AP-1   ATF-2   E2F-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCUTA promoter sequence
   Search SABiosciences Chromatin IP Primers for CUTA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CUTA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.32   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.32

CUTA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CUTA gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M033384:  view genomic region     (about GC identifiers)

Start:
33,384,219 bp from pter      End:
33,386,094 bp from pter
Size:
1,876 bases      Orientation:
minus strand

1 alternative location:
Chr6-,ALT_REF_LOCI_7 33,454,030-33,455,776     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CUTA_HUMAN, O60888 (See protein sequence)
Recommended Name: Protein CutA precursor  
Size: 179 amino acids; 19116 Da
Subunit: Homotrimer
Sequence caution: Sequence=AAF61220.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for CUTA:
1XK8 (3D)        2ZFH (3D)    
Secondary accessions: A2AB26 A2BEL4 Q3B784 Q5JXM9 Q5SU05 Q9NYQ9
Alternative splicing: 3 isoforms:  O60888-1   O60888-2   O60888-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CUTA: NX_O60888

Post-translational modifications:

  • O-glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60888

  • CUTA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001014433.1  NP_001014837.1  NP_001014838.1  NP_001014840.1  NP_057005.1  

    ENSEMBL proteins: 
     ENSP00000363624   ENSP00000417544   ENSP00000418659   ENSP00000418612   ENSP00000417823  
     ENSP00000363608   ENSP00000363620   ENSP00000403268  

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    ProSpec Recombinant Protein for CUTA
    Uscn Proteins for CUTA

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane IDA10800960


    CUTA for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CUTA for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR004323 Ion_tolerance_CutA
     IPR011322 N-reg_PII-like_a/b

    Graphical View of Domain Structure for InterPro Entry O60888

    ProtoNet protein and cluster: O60888

    UniProtKB/Swiss-Prot: CUTA_HUMAN, O60888
    Similarity: Belongs to the CutA family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CUTA_HUMAN, O60888
    Function: May form part of a complex of membrane proteins attached to acetylcholinesterase (AChE)

    miRNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0019899enzyme binding IPI10800960


    CUTA for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CUTA:
     Elongated cells 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CUTA

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/9 Interacting proteins for CUTA (O608881, 3 ENSP000003636244) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR4A1P227361, 3EBI-1051556,EBI-721550 I2D: score=1 
    GRB2P629933, ENSP000003390074I2D: score=2 STRING: ENSP00000339007
    MCCP235083I2D: score=1 
    MLH1P406923I2D: score=1 
    PINX1Q96BK53I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008104protein localization IDA10800960
    GO:0010038response to metal ion IEA--
    GO:0051260protein homooligomerization ----


    CUTA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CUTA
    Search CenterWatch for drugs/clinical trials and news about CUTA 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CUTA gene (5 alternative transcripts): 
    NM_001014433.2  NM_001014837.1  NM_001014838.1  NM_001014840.1  NM_015921.2  

    Unigene Cluster for CUTA:

    CutA divalent cation tolerance homolog (E. coli)
    Hs.520070  [show with all ESTs]
    Unigene Representative Sequence: BM913222
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000462802 ENST00000374500(uc003oen.1) ENST00000479249 ENST00000488034
    ENST00000494751 ENST00000488478 ENST00000482684 ENST00000374484 ENST00000465956
    ENST00000487637 ENST00000374496 ENST00000492510 ENST00000440279(uc003oej.1 uc003oem.1 uc003oek.1 uc003oel.1)


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    Additional cDNA sequence: 

    AF106943.1 AF230924.1 AK311556.1 BC005890.2 BC107751.1 

    19 DOTS entries:

    DT.100823864  DT.80101365  DT.95294758  DT.97855893  DT.92448614  DT.100722977  DT.92448612  DT.100715447 
    DT.92414190  DT.95364357  DT.100823865  DT.100823856  DT.92448596  DT.92448603  DT.100823861  DT.92448604 
    DT.121319942  DT.95364351  DT.92354396 

    24/444 AceView cDNA sequences (see all 444):

    BQ679689 AI476771 BM856483 CR613274 AI342536 AJ708756 BI829298 BX396632 
    BU785543 AV691035 CR620346 BE348323 BC005890 BE792779 AA329903 CR606293 
    AA429256 CR595524 Z45875 BE386188 BQ676568 CB130698 BM782722 CR590722 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CUTA (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e
    SP1:                    -     -     -     -                 -                                                   
    SP2:                    -     -     -     -                 -                                                   
    SP3:                                -     -                 -                                                   
    SP4:                                      -                 -                                                   
    SP5:                                                        -                                                   


    ECgene alternative splicing isoforms for CUTA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CUTA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGATCCCCG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CUTA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CUTA

    SOURCE GeneReport for Unigene cluster: Hs.520070

    UniProtKB/Swiss-Prot: CUTA_HUMAN, O60888
    Tissue specificity: Ubiquitous. Widely expressed in brain

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for CUTA gene from 9/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cuta1 , 5 cutA divalent cation tolerance homolog (E. coli)1, 5 87.01(n)1
    90.4(a)1
      17 (13.60 cM)5
    676751  NM_026307.21  NP_080583.31 
     269379735 
    chicken
    (Gallus gallus)
    Aves CUTA6
    Uncharacterized protein
    34(a)
    1 ↔ 1
    17(8979362-8985595)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.89742 Transcribed sequence with moderate similarity to protein more 71.53(n)    CF782916.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.101502 Transcribed sequence with weak similarity to protein more 75.1(n)    57091244 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG115901 CG11590 51.44(n)
    50.86(a)
      32368  NM_132717.1  NP_572945.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F35G12.76
    Protein F35G12.7
    37(a)
    1 ↔ 1
    III(4586436-4587283)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CUTA1 protein CutA 49.22(n)
    42.97(a)
      817940  NM_128933.3  NP_180930.1 
    rice
    (Oryza sativa)
    Liliopsida Os10g03783001 hypothetical protein 48.4(n)
    44.44(a)
      4348499  NM_001071015.1  NP_001064480.1 
    E. coli
    (Escherichia coli)
    Gamma proteobacteria cutA6
    divalent-cation tolerance protein, copper sensitiv...
    37(a)
    1 ↔ 1
    Chromosome(4363041-4363379)


    ENSEMBL Gene Tree for CUTA (if available)
    TreeFam Gene Tree for CUTA (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/24 NCBI SNPs in CUTA are shown (see all 24    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1145405731,2
    C,F,--33384734(+) ACTTTG/TGGTTT 10 K Q mis11Minor allele frequency- T:0.00NA 4552
    rs2012681501,2
    --33384746(+) AATCAC/TCTAAG 10 M V mis10--------
    rs2008392291,2
    --33384755(+) AGGGAC/TAAAGA 5 -- int10--------
    rs734023031,2
    C,--33385006(+) GTTAAC/TCCCCC 5 -- int13Minor allele frequency- T:0.33WA CSA 122
    rs2003763941,2
    --33385076(+) GCTTCA/TCCACC 10 E V mis10--------
    rs1437280191,2
    C,--33385090(+) GCCCTA/GGAGTG 5 -- int10--------
    rs1468235911,2
    --33385205(+) CCCACC/TCCCAA 5 -- int10--------
    rs1398203651,2
    F--33385298(+) AGTAAC/GAAAGG 10 L V mis11Minor allele frequency- G:0.00NA 4412
    rs1900674531,2
    C,--33385477(+) CCTGAA/GAGCAG 5 -- int1 ut510--------
    rs1458122821,2
    C,--33385527(+) TTACA-/CCCGGG 5 -- int1 ut510--------

    HapMap Linkage Disequilibrium report for CUTA (33384219 - 33386094 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CUTA: --
    Human Gene Mutation Database (HGMD): CUTA

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CUTA
    DNA2.0 Custom Variant and Variant Library Synthesis for CUTA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CUTA for disorders           About GeneDecksing

    5 diseases for CUTA:    About MalaCards
    systemic lupus erythematosus    lupus erythematosus    intrahepatic cholangiocarcinoma    cholangiocarcinoma
    malaria

    Human Genome Epidemiology (HuGE) Navigator: CUTA (2 documents)

    Export disorders for CUTA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CUTA gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with CUTA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two distinct proteins are associated with tetrameric acetylcholinesterase on the cell surface. (PubMed id 10954708)1, 2, 9 Perrier A.L.... Krejci E. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    4. Hydrophobic protein that copurifies with human brain acetylcholinesterase: amino acid sequence, genomic organization, and chromosomal localization. (PubMed id 10800960)1, 2 Navaratnam D.S.... Smith A.D. (2000)
    5. Characterization of the human CUTA isoform2 present in the stably transfected HeLa cells. (PubMed id 17924204)1, 9 Yang J....Yu L. (2009)
    6. LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins. (PubMed id 23234360)2 Halim A.... Nilsson J. (2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. CutA divalent cation tolerance homolog (Escherichia co li) (CUTA) regulates b-cleavage of b-amyloid precursor protein (APP) through int eracting with b-site APP cleaving protein 1 (BACE1). (PubMed id 22351782)1 Zhao Y....Zhang Y.W. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51596 HGNC: 21101 AceView: C6orf82 Ensembl:ENSG00000112514 euGenes: HUgn51596
    ECgene: CUTA H-InvDB: CUTA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for CUTA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for CUTA gene:
    Search GeneIP for patents involving CUTA

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