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Aliases for CUTA Gene

Aliases for CUTA Gene

  • CutA Divalent Cation Tolerance Homolog 2 3 5
  • Acetylcholinesterase-Associated Protein 2 3 4
  • Brain Acetylcholinesterase Putative Membrane Anchor 3 4
  • C6orf82 3 4
  • ACHAP 3 4
  • CutA Divalent Cation Tolerance Homolog (E. Coli) 2
  • Divalent Cation Tolerant Protein CUTA 3
  • Chromosome 6 Open Reading Frame 82 2
  • Protein CutA 3

External Ids for CUTA Gene

Previous HGNC Symbols for CUTA Gene

  • C6orf82
  • ACHAP

Previous GeneCards Identifiers for CUTA Gene

  • GC06M033493
  • GC06M033126

Summaries for CUTA Gene

GeneCards Summary for CUTA Gene

CUTA (CutA Divalent Cation Tolerance Homolog) is a Protein Coding gene. Diseases associated with CUTA include Diabetes Mellitus, Permanent Neonatal. GO annotations related to this gene include enzyme binding.

UniProtKB/Swiss-Prot for CUTA Gene

  • May form part of a complex of membrane proteins attached to acetylcholinesterase (AChE).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUTA Gene

Genomics for CUTA Gene

Regulatory Elements for CUTA Gene

Enhancers for CUTA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G033414 1.8 FANTOM5 ENCODE dbSUPER 10.5 +0.6 608 6.4 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 RING1 SYNGAP1 CUTA HLA-DPB1 TAPBP DAXX HLA-DPA1 HLA-DMA BRD2 HLA-DMB
GH06G033341 1.7 FANTOM5 Ensembl ENCODE 10.9 +74.3 74345 4.0 HDGF PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 FEZF1 DAXX TAPBP PHF1 WDR46 RGL2 ZBTB22 PFDN6 KIFC1 RPL35AP4 CUTA
GH06G033423 1.8 FANTOM5 ENCODE dbSUPER 10.2 -7.6 -7648 3.9 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A YBX1 DMAP1 FEZF1 DAXX WDR46 BRD2 VPS52 LEMD2 RXRB ZBTB9 KIFC1 RPL35AP4 SYNGAP1
GH06G033428 1.6 FANTOM5 ENCODE dbSUPER 10.5 -10.8 -10794 1.7 HDGF PKNOX1 ATF1 FOXA2 ZFP64 ARID4B SIN3A YBX1 DMAP1 TCF12 ZBTB9 SMIM29 RPL35AP4 KIFC1 CUTA BAK1 SYNGAP1 MIR5004
GH06G033430 1.5 FANTOM5 ENCODE dbSUPER 10.1 -14.1 -14103 4.5 HDGF ATF1 FOXA2 ARID4B SIN3A ZNF48 GLIS2 ELK1 ZNF143 FOS RING1 HCG25 DAXX ZBTB9 SYNGAP1 LEMD2 VPS52 SMIM29 PHF1 KIFC1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CUTA on UCSC Golden Path with GeneCards custom track

Promoters for CUTA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000320342 517 1601 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3

Genomic Location for CUTA Gene

Chromosome:
6
Start:
33,416,442 bp from pter
End:
33,418,317 bp from pter
Size:
1,876 bases
Orientation:
Minus strand

Genomic View for CUTA Gene

Genes around CUTA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CUTA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CUTA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUTA Gene

Proteins for CUTA Gene

  • Protein details for CUTA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60888-CUTA_HUMAN
    Recommended name:
    Protein CutA
    Protein Accession:
    O60888
    Secondary Accessions:
    • A2AB26
    • A2BEL4
    • Q3B784
    • Q5JXM9
    • Q5SU05
    • Q9NYQ9

    Protein attributes for CUTA Gene

    Size:
    179 amino acids
    Molecular mass:
    19116 Da
    Quaternary structure:
    • Homotrimer.
    SequenceCaution:
    • Sequence=AAF61220.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CUTA Gene

    Alternative splice isoforms for CUTA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CUTA Gene

Post-translational modifications for CUTA Gene

Antibody Products

  • Abcam antibodies for CUTA
  • Santa Cruz Biotechnology (SCBT) Antibodies for CUTA

No data available for DME Specific Peptides for CUTA Gene

Domains & Families for CUTA Gene

Protein Domains for CUTA Gene

Suggested Antigen Peptide Sequences for CUTA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60888

UniProtKB/Swiss-Prot:

CUTA_HUMAN :
  • Belongs to the CutA family.
Family:
  • Belongs to the CutA family.
genes like me logo Genes that share domains with CUTA: view

No data available for Gene Families for CUTA Gene

Function for CUTA Gene

Molecular function for CUTA Gene

UniProtKB/Swiss-Prot Function:
May form part of a complex of membrane proteins attached to acetylcholinesterase (AChE).

Gene Ontology (GO) - Molecular Function for CUTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005507 copper ion binding IBA --
GO:0005515 protein binding IPI 20195357
GO:0019899 enzyme binding IPI 10800960
genes like me logo Genes that share ontologies with CUTA: view

Phenotypes for CUTA Gene

genes like me logo Genes that share phenotypes with CUTA: view

Animal Model Products

CRISPR Products

miRNA for CUTA Gene

miRTarBase miRNAs that target CUTA

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CUTA Gene

Localization for CUTA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CUTA gene
Compartment Confidence
extracellular 5
mitochondrion 2
plasma membrane 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CUTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 10800960
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CUTA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CUTA Gene

Pathways & Interactions for CUTA Gene

No Data Available

Gene Ontology (GO) - Biological Process for CUTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008104 protein localization IDA 10800960
GO:0010038 response to metal ion IEA --
genes like me logo Genes that share ontologies with CUTA: view

No data available for Pathways by source and SIGNOR curated interactions for CUTA Gene

Transcripts for CUTA Gene

Unigene Clusters for CUTA Gene

CutA divalent cation tolerance homolog (E. coli):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CUTA Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: -
SP6: - -
SP7: - -
SP8:
SP9:

Relevant External Links for CUTA Gene

GeneLoc Exon Structure for
CUTA
ECgene alternative splicing isoforms for
CUTA

Expression for CUTA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CUTA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CUTA Gene



Protein tissue co-expression partners for CUTA Gene

NURSA nuclear receptor signaling pathways regulating expression of CUTA Gene:

CUTA

SOURCE GeneReport for Unigene cluster for CUTA Gene:

Hs.520070

mRNA Expression by UniProt/SwissProt for CUTA Gene:

O60888-CUTA_HUMAN
Tissue specificity: Ubiquitous. Widely expressed in brain.

Evidence on tissue expression from TISSUES for CUTA Gene

  • Liver(4.4)
  • Nervous system(3.8)
  • Stomach(2.7)
  • Kidney(2.6)
  • Muscle(2.6)
  • Heart(2.3)
  • Skin(2.3)
  • Lung(2.2)
  • Eye(2.1)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with CUTA: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CUTA Gene

Orthologs for CUTA Gene

This gene was present in the common ancestor of animals.

Orthologs for CUTA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CUTA 34 35
  • 99.44 (n)
cow
(Bos Taurus)
Mammalia CUTA 34 35
  • 88.89 (n)
dog
(Canis familiaris)
Mammalia CUTA 34 35
  • 88.14 (n)
mouse
(Mus musculus)
Mammalia Cuta 34 16 35
  • 87.01 (n)
rat
(Rattus norvegicus)
Mammalia Cuta 34
  • 85.12 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 69 (a)
OneToMany
-- 35
  • 63 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CUTA 35
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves CUTA 35
  • 33 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cuta 34
  • 66.67 (n)
Str.8974 34
zebrafish
(Danio rerio)
Actinopterygii LOC100535353 34
  • 68.63 (n)
CUTA 35
  • 61 (a)
OneToOne
Dr.10150 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10007 34
fruit fly
(Drosophila melanogaster)
Insecta CG11590 35
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F35G12.7 35
  • 37 (a)
OneToOne
Species where no ortholog for CUTA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CUTA Gene

ENSEMBL:
Gene Tree for CUTA (if available)
TreeFam:
Gene Tree for CUTA (if available)

Paralogs for CUTA Gene

No data available for Paralogs for CUTA Gene

Variants for CUTA Gene

Sequence variations from dbSNP and Humsavar for CUTA Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1001093191 -- 33,419,095(+) TGGGA(C/G)GAGGT upstream-variant-2KB
rs1002716361 -- 33,418,485(+) GATGC(G/T)TCAGG upstream-variant-2KB
rs1003275531 -- 33,420,175(+) CCTCC(C/T)CCTCC upstream-variant-2KB, utr-variant-5-prime
rs1004492886 -- 33,416,085(+) AGGAG(A/G)GGGCA nc-transcript-variant, downstream-variant-500B, reference, missense, utr-variant-3-prime
rs1004624786 -- 33,420,017(+) CCTCC(-/TCG)TCCTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CUTA Gene

Variant ID Type Subtype PubMed ID
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1119076 CNV deletion 24896259
nsv602832 CNV loss 21841781
nsv830635 CNV loss 17160897
nsv830637 CNV loss 17160897

Variation tolerance for CUTA Gene

Residual Variation Intolerance Score: 82.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.55; 72.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CUTA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CUTA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CUTA Gene

Disorders for CUTA Gene

MalaCards: The human disease database

(1) MalaCards diseases for CUTA Gene - From: DISEASES

Disorder Aliases PubMed IDs
diabetes mellitus, permanent neonatal
  • diabetes, permanent neonatal
- elite association - COSMIC cancer census association via MalaCards
Search CUTA in MalaCards View complete list of genes associated with diseases

Relevant External Links for CUTA

Genetic Association Database (GAD)
CUTA
Human Genome Epidemiology (HuGE) Navigator
CUTA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CUTA
genes like me logo Genes that share disorders with CUTA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CUTA Gene

Publications for CUTA Gene

  1. Two distinct proteins are associated with tetrameric acetylcholinesterase on the cell surface. (PMID: 10954708) Perrier A.L. … Krejci E. (J. Biol. Chem. 2000) 3 4 22 64
  2. The role of copper and the copper-related protein CUTA in mediating APP processing and AI^ generation. (PMID: 25557959) Hou P. … Zhang Y.W. (Neurobiol. Aging 2015) 2 3 64
  3. CutA divalent cation tolerance homolog (Escherichia coli) (CUTA) regulates I^-cleavage of I^-amyloid precursor protein (APP) through interacting with I^-site APP cleaving protein 1 (BACE1). (PMID: 22351782) Zhao Y. … Zhang Y.W. (J. Biol. Chem. 2012) 2 3 64
  4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 46 64
  5. Characterization of the human CUTA isoform2 present in the stably transfected HeLa cells. (PMID: 17924204) Yang J. … Yu L. (Mol. Biol. Rep. 2009) 3 22 64

Products for CUTA Gene

Sources for CUTA Gene

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