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Aliases for CUL9 Gene

Aliases for CUL9 Gene

  • Cullin 9 2 3
  • P53-Associated Parkin-Like Cytoplasmic Protein 2 3 4
  • PARC 3 4 6
  • Parkin-Like Cytoplasmic P53 Binding Protein 2 3
  • UbcH7-Associated Protein 1 3 4
  • KIAA0708 4 6
  • CUL-9 3 4
  • H7AP1 3 4
  • Cullin-9 3

External Ids for CUL9 Gene

Summaries for CUL9 Gene

GeneCards Summary for CUL9 Gene

CUL9 (Cullin 9) is a Protein Coding gene. GO annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is CUL7.

UniProtKB/Swiss-Prot for CUL9 Gene

  • Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328).

Gene Wiki entry for CUL9 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUL9 Gene

Genomics for CUL9 Gene

Genomic Location for CUL9 Gene

Start:
43,182,175 bp from pter
End:
43,224,587 bp from pter
Size:
42,413 bases
Orientation:
Plus strand

Genomic View for CUL9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CUL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUL9 Gene

Regulatory Elements for CUL9 Gene

Proteins for CUL9 Gene

  • Protein details for CUL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWT3-CUL9_HUMAN
    Recommended name:
    Cullin-9
    Protein Accession:
    Q8IWT3
    Secondary Accessions:
    • O75188
    • Q5TCY3
    • Q68CP2
    • Q68D92
    • Q8N3W9
    • Q9BU56

    Protein attributes for CUL9 Gene

    Size:
    2517 amino acids
    Molecular mass:
    281229 Da
    Quaternary structure:
    • Part of a Cul9-RING complex at least composed of CUL9 and RBX1. Interacts with CUL7: interaction with CUL7 component of the 3M complex leads to inhibition of CUL9 activity. The CUL7-CUL9 heterodimer seems to interact specifically with TP53. Forms a complex with p53/TP53 in the cytoplasm of unstressed cells. Interacts with UBCH7 and UBCH8.
    SequenceCaution:
    • Sequence=BAC85207.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAC86090.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CUL9 Gene

    Alternative splice isoforms for CUL9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CUL9 Gene

Proteomics data for CUL9 Gene at MOPED

Post-translational modifications for CUL9 Gene

Other Protein References for CUL9 Gene

No data available for DME Specific Peptides for CUL9 Gene

Domains for CUL9 Gene

UniProtKB/Swiss-Prot:

CUL9_HUMAN
Domain:
  • The IBR domain is required for interaction with UBCH7 and UBCH8:
    • Q8IWT3
  • Contains 1 DOC domain.:
    • Q8IWT3
Family:
  • Belongs to the cullin family.:
    • Q8IWT3
Similarity:
  • Contains 1 IBR-type zinc finger.:
    • Q8IWT3
  • Contains 2 RING-type zinc fingers.:
    • Q8IWT3
genes like me logo Genes that share domains with CUL9: view

No data available for Gene Families for CUL9 Gene

Function for CUL9 Gene

Molecular function for CUL9 Gene

UniProtKB/Swiss-Prot Function: Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328).

Gene Ontology (GO) - Molecular Function for CUL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 18230339
GO:0005524 ATP binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0031625 ubiquitin protein ligase binding IEA --
genes like me logo Genes that share ontologies with CUL9: view
genes like me logo Genes that share phenotypes with CUL9: view

Animal Models for CUL9 Gene

MGI Knock Outs for CUL9:

miRNA for CUL9 Gene

miRTarBase miRNAs that target CUL9

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CUL9 Gene

Localization for CUL9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CUL9 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CUL9 Gene COMPARTMENTS Subcellular localization image for CUL9 gene
Compartment Confidence
nucleus 3
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CUL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0031461 cullin-RING ubiquitin ligase complex IDA 24793696
genes like me logo Genes that share ontologies with CUL9: view

Pathways for CUL9 Gene

SuperPathways for CUL9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CUL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IMP 24793696
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0007088 regulation of mitotic nuclear division IMP 24793696
GO:0016567 protein ubiquitination IDA 24793696
genes like me logo Genes that share ontologies with CUL9: view

No data available for Pathways by source for CUL9 Gene

Transcripts for CUL9 Gene

Unigene Clusters for CUL9 Gene

Cullin 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CUL9 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^
SP1: - - - - -
SP2: - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: -

ExUns: 20a · 20b ^ 21a · 21b · 21c ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34a · 34b ^ 35 ^ 36 ^ 37 ^ 38 ^
SP1: - - - - -
SP2:
SP3: - - - -
SP4: -
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

ExUns: 39 ^ 40a · 40b ^ 41a · 41b ^ 42 ^ 43 ^ 44
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:

Relevant External Links for CUL9 Gene

GeneLoc Exon Structure for
CUL9
ECgene alternative splicing isoforms for
CUL9

Expression for CUL9 Gene

mRNA expression in normal human tissues for CUL9 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CUL9 Gene

SOURCE GeneReport for Unigene cluster for CUL9 Gene Hs.485434

mRNA Expression by UniProt/SwissProt for CUL9 Gene

Q8IWT3-CUL9_HUMAN
Tissue specificity: Ubiquitously expressed in all tissues with highest expression in testis brain and kidney.
genes like me logo Genes that share expressions with CUL9: view

Orthologs for CUL9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CUL9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CUL9 36
  • 99.47 (n)
  • 99.28 (a)
CUL9 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CUL9 36
  • 87.7 (n)
  • 88.84 (a)
CUL9 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CUL9 36
  • 89.96 (n)
  • 91.62 (a)
CUL9 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cul9 36
  • 85.4 (n)
  • 86.66 (a)
Cul9 16
Cul9 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 72 (a)
ManyToMany
-- 37
  • 75 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 64 (a)
ManyToMany
-- 37
  • 60 (a)
ManyToMany
-- 37
  • 59 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cul9 36
  • 85.57 (n)
  • 86.82 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 35 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 57 (a)
ManyToMany
-- 37
  • 48 (a)
ManyToMany
-- 37
  • 55 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cul9 36
  • 61.02 (n)
  • 55.69 (a)
Str.19701 36
zebrafish
(Danio rerio)
Actinopterygii CABZ01087282.1 37
  • 50 (a)
ManyToMany
CABZ01087282.2 37
  • 53 (a)
ManyToMany
cul9 36
  • 59.62 (n)
  • 54.54 (a)
wufc02b11 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 33 (a)
OneToMany
Species with no ortholog for CUL9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CUL9 Gene

ENSEMBL:
Gene Tree for CUL9 (if available)
TreeFam:
Gene Tree for CUL9 (if available)

Paralogs for CUL9 Gene

Paralogs for CUL9 Gene

Selected SIMAP similar genes for CUL9 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CUL9: view

Variants for CUL9 Gene

Sequence variations from dbSNP and Humsavar for CUL9 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs737259 -- 43,201,039(-) TACCT(A/G)TTGGA intron-variant
rs941849 -- 43,186,353(+) ACACT(C/G)CAGCC synonymous-codon, reference, upstream-variant-2KB, nc-transcript-variant
rs1214714 -- 43,214,919(+) gtgca(A/G)tgagc intron-variant
rs2273709 - 43,216,394(+) CGTAC(A/C)CCAGG reference, missense
rs2651195 -- 43,220,028(+) CGGAC(A/G)GTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CUL9 Gene

Variant ID Type Subtype PubMed ID
nsv521730 CNV Loss 19592680
esv2671960 CNV Deletion 23128226
dgv6839n71 CNV Loss 21882294

Relevant External Links for CUL9 Gene

HapMap Linkage Disequilibrium report
CUL9

Disorders for CUL9 Gene

(1) University of Copenhagen DISEASES for CUL9 Gene

Relevant External Links for CUL9

Genetic Association Database (GAD)
CUL9
Human Genome Epidemiology (HuGE) Navigator
CUL9
genes like me logo Genes that share disorders with CUL9: view

No data available for UniProtKB/Swiss-Prot for CUL9 Gene

Publications for CUL9 Gene

  1. The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1. (PMID: 10521492) Moynihan T.P. … Robinson P.A. (J. Biol. Chem. 1999) 2 3 4 23
  2. Parc: a cytoplasmic anchor for p53. (PMID: 12526791) Nikolaev A.Y. … Gu W. (Cell 2003) 2 3 4
  3. PARC and CUL7 form atypical cullin RING ligase complexes. (PMID: 17332328) Skaar J.R. … DeCaprio J.A. (Cancer Res. 2007) 2 3 4
  4. Dimerization of CUL7 and PARC is not required for all CUL7 functions and mouse development. (PMID: 15964813) Skaar J.R. … DeCaprio J.A. (Mol. Cell. Biol. 2005) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CUL9 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Ubiquitin Ligases in human,mouse,rat
    • Ubiquitination (Ubiquitylation) Pathway in human,mouse,rat
    • p53 Signaling Pathway in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CUL9
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CUL9
    • Block miRNA regulation of CUL9 using miScript Target Protectors

    Sources for CUL9 Gene

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