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CUL9 Gene

protein-coding   GIFtS: 55
GCID: GC06P043149

Cullin 9

Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cullin 91 2     H7AP12 3
P53-Associated Parkin-Like Cytoplasmic Protein1 2 3     UbcH7-Associated Protein 12 3
PARC2 3 5     KIAA07083 5
Parkin-Like Cytoplasmic P53 Binding Protein1 2     cullin-92
CUL-92 3     

External Ids:    HGNC: 159821   Entrez Gene: 231132   Ensembl: ENSG000001126597   OMIM: 6074895   UniProtKB: Q8IWT33   

Export aliases for CUL9 gene to outside databases

Previous GC identifers: GC06P043258 GC06P042866


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CUL9 Gene:
CUL9 (cullin 9) is a protein-coding gene. Diseases associated with CUL9 include peyronie's disease, and peyronies disease. GO annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is CUL7.

UniProtKB/Swiss-Prot: CUL9_HUMAN, Q8IWT3
Function: Cytoplasmic anchor protein in p53-associated protein complex. Regulates the subcellular localization of
p53 and subsequent function. Seems to be part of an atypical cullin-RING-based E3 ubiquitin-protein ligase
complex. In vitro, complexes of CUL9/PARC with either CUL7 or TP53 contain E3 ubiquitin-protein ligase activity

Gene Wiki entry for CUL9 (PARC) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CUL9 gene promoter:
         SRF   SRF (504 AA)   MyoD   Nkx2-5   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CUL9 promoter sequence
   Search Chromatin IP Primers for CUL9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CUL9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

CUL9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CUL9 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P043149:  view genomic region     (about GC identifiers)

Start:
43,149,913 bp from pter      End:
43,192,325 bp from pter
Size:
42,413 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CUL9_HUMAN, Q8IWT3 (See protein sequence)
Recommended Name: Cullin-9  
Size: 2517 amino acids; 281229 Da
Subunit: Forms a complex with p53/TP53 in the cytoplasm of unstressed cells. Interacts with UBCH7 and UBCH8.
Interacts with CUL7 and RBX1. The CUL7-CUL9 heterodimer seems to interact specifically with TP53
Sequence caution: Sequence=BAC85207.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=BAC86090.1;
Type=Miscellaneous discrepancy; Note=Intron retention;
1 PDB 3D structure from and Proteopedia for CUL9:
2JUF (3D)    
Secondary accessions: O75188 Q5TCY3 Q68CP2 Q68D92 Q8N3W9 Q9BU56
Alternative splicing: 2 isoforms:  Q8IWT3-1   Q8IWT3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CUL9: NX_Q8IWT3

Explore proteomics data for CUL9 at MOPED

Post-translational modifications: 

  • In vitro, self-ubiquitination in the presence of E1, E2 and ubiquitin1
  • Neddylated1
  • Ubiquitination2 at Lys87, Lys1299, Lys1718, Lys2144
  • Modification sites at PhosphoSitePlus

  • See CUL9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055904.1  
    ENSEMBL proteins: 
     ENSP00000252050   ENSP00000361730   ENSP00000421116   ENSP00000425649   ENSP00000346490  

    CUL9 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CUL9
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    Novus Biologicals CUL9 Proteins
    Novus Biologicals CUL9 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CUL9

    CUL9 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for CUL9
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    LSBio Antibodies in human, mouse, rat for CUL9

    CUL9 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for CUL9
    Cloud-Clone Corp. CLIAs for CUL9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 14):
     IPR004939 APC_su10/DOC_dom
     IPR001841 Znf_RING
     IPR011989 ARM-like
     IPR019559 Cullin_neddylation_domain
     IPR016157 Cullin_CS

    Graphical View of Domain Structure for InterPro Entry Q8IWT3

    ProtoNet protein and cluster: Q8IWT3

    3 Blocks protein domains:
    IPB000357 HEAT repeat
    IPB001841 Zn-finger
    IPB002867 Zn-finger


    UniProtKB/Swiss-Prot: CUL9_HUMAN, Q8IWT3
    Domain: The IBR domain is required for interaction with UBCH7 and UBCH8
    Similarity: Belongs to the cullin family
    Similarity: Contains 1 DOC domain
    Similarity: Contains 1 IBR-type zinc finger
    Similarity: Contains 2 RING-type zinc fingers


    CUL9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CUL9_HUMAN, Q8IWT3
    Function: Cytoplasmic anchor protein in p53-associated protein complex. Regulates the subcellular localization of
    p53 and subsequent function. Seems to be part of an atypical cullin-RING-based E3 ubiquitin-protein ligase
    complex. In vitro, complexes of CUL9/PARC with either CUL7 or TP53 contain E3 ubiquitin-protein ligase activity

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI18230339
    GO:0005524ATP binding IEA--
    GO:0008270zinc ion binding IEA--
    GO:0031625ubiquitin protein ligase binding IEA--
         
    CUL9 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CUL9:
     Decreased viability of wild-ty 

         7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Cul9):
     cellular  growth/size/body  homeostasis/metabolism  mortality/aging  no phenotypic analysis 
     normal  tumorigenesis 

    CUL9 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CUL9: Cul9tm2Jdec Cul9tm1.2Yxi Cul9tm1Jdec

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CUL9
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CUL9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CUL9
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CUL9

    miRNA
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    miRTarBase miRNAs that target CUL9:
    hsa-mir-335-5p (MIRT019029)

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    Predesigned siRNA for gene silencing in human, mouse, rat CUL9

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    GenScript: all cDNA clones in your preferred vector: CUL9 (NM_015089)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CUL9
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CUL9

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUL9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CUL9_HUMAN, Q8IWT3: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0031461cullin-RING ubiquitin ligase complex IEA--

    CUL9 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including CUL9: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CUL9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for CUL9 (Q8IWT31, 2, 3 ENSP000002520504) via UniProtKB, MINT, STRING, and/or I2D (see all 76)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046371, 2, 3, ENSP000002693054EBI-311123,EBI-366083 MINT-8415355 I2D: score=5 STRING: ENSP00000269305
    PLXNB3Q9ULL43, ENSP000003553784I2D: score=3 STRING: ENSP00000355378
    UBE2G2P606043, ENSP000003383484I2D: score=1 STRING: ENSP00000338348
    CUL7Q149992, ENSP000002653484MINT-8415355 STRING: ENSP00000265348
    UBE2L3P680363, ENSP000003442594I2D: score=3 STRING: ENSP00000344259
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--

    CUL9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CUL9



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CUL9 gene: 
    NM_015089.3  

    Unigene Cluster for CUL9:

    Cullin 9
    Hs.485434  [show with all ESTs]
    Unigene Representative Sequence: CR749511
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000252050(uc003ouk.3 uc003oul.3) ENST00000451399(uc003ouj.1)
    ENST00000515773(uc010jyk.3) ENST00000372647 ENST00000510282(uc003oum.1)
    ENST00000515344 ENST00000512408 ENST00000504485 ENST00000502719 ENST00000505172
    ENST00000502937 ENST00000513904 ENST00000508656 ENST00000506830 ENST00000512423
    ENST00000503766 ENST00000505405 ENST00000504647

    miRNA
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    Search for qRT-PCR Assays for microRNAs that regulate CUL9
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CUL9
    Predesigned siRNA for gene silencing in human, mouse, rat CUL9
    Clone
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    OriGene ORF clones in mouse, rat for CUL9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CUL9 (NM_015089)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CUL9
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CUL9
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CUL9
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CUL9
      QuantiTect SYBR Green Assays in human, mouse, rat CUL9
      QuantiFast Probe-based Assays in human, mouse, rat CUL9

    Additional mRNA sequence: 

    AB014608.3 AJ318215.1 AK125228.1 AK128364.1 AK129649.1 AY145132.1 BC002879.2 BC017747.1 
    BC028159.1 CR749511.1 CR749841.1 

    15 DOTS entries:

    DT.108384  DT.101973181  DT.92421315  DT.110448  DT.101977720  DT.423126  DT.95280257  DT.101961651 
    DT.95263374  DT.97857839  DT.40221218  DT.40268324  DT.75197655  DT.91876491  DT.97768546 

    Selected AceView cDNA sequences (see all 131):

    AI038289 AI694794 H79495 AB014608 AK125228 BC017747 AL042586 BX354806 
    AA970458 AI540798 AK129649 AA433938 CA306112 NM_015089 BQ949462 BU688112 
    BM128558 CA306236 CB305800 BC028159 CR749511 CK824035 AA481333 AJ318215 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CUL9 (see all 14)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^
    SP1:                                -                       -           -                       -                                                     -         
    SP2:                                -     -     -                                                                                                               
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20a · 20b ^ 21a · 21b · 21c ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34a · 34b ^ 35 ^ 36 ^ 37 ^ 38 ^
    SP1:        -     -                             -                                   -                 -                                                         
    SP2:                                                                                                                                                            
    SP3:                                                                    -     -     -                 -                                                         
    SP4:                                                                                                  -                                                         
    SP5:                                                                                                                                                            

    ExUns: 39 ^ 40a · 40b ^ 41a · 41b ^ 42 ^ 43 ^ 44
    SP1:        -                 -                     
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for CUL9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CUL9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGGCAGTC
    CUL9 Expression
    About this image

    CUL9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CUL9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.485434

    UniProtKB/Swiss-Prot: CUL9_HUMAN, Q8IWT3
    Tissue specificity: Ubiquitously expressed in all tissues with highest expression in testis brain and kidney

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CUL9: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CUL9
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CUL9
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    QuantiFast Probe-based Assays in human, mouse, rat CUL9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUL9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CUL9 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cul91 , 5 cullin 91, 5 85.4(n)1
    86.66(a)1
      17 (22.90 cM)5
    783091  NM_001081335.21  NP_001074804.21 
     465005725 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    35(a)
    1 → many
    3(4356083-4375184)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    57(a)
    55(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2(143790886-143864663)
    2(144228552-144239569)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ070967.12   -- 80.41(n)    BJ070967.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc02b112 Transcribed sequence with weak similarity to protein more 74.02(n)    BM102277.1 


    ENSEMBL Gene Tree for CUL9 (if available)
    TreeFam Gene Tree for CUL9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CUL9 gene
    CUL72  ZZEF12  
    1 SIMAP similar gene for CUL9 using alignment to 6 protein entries:     CUL9_HUMAN (see all proteins):
    CUL7

    CUL9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CUL9 (see all 1076)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs755414291,2
    C,F--43149778(+) CCCACG/ACCCCT 1 -- us2k11Minor allele frequency- A:0.07NA 120
    rs1815927751,2
    --43149796(+) TGCAGC/TCGCCC 1 -- us2k10--------
    rs801401741,2
    C,F--43150037(+) GTCCCC/TTCCCC 1 -- int12Minor allele frequency- T:0.10CSA WA 120
    rs1862107091,2
    --43150122(+) AGCTTC/TTTTGG 1 -- int10--------
    rs1494487441,2
    --43150209(+) GGCTCC/TGCAAG 1 -- int10--------
    rs1430331171,2
    C--43150253(+) CCATGA/CGTCCA 1 -- int10--------
    rs1483646411,2
    --43150276(+) ACACCC/TCAGTT 1 -- int10--------
    rs168689931,2
    C,F,H--43150302(+) AGGCCG/CACGTT 1 -- int126Minor allele frequency- C:0.37NA NS EA WA CSA 2899
    rs1909791221,2
    --43150321(+) TACCTC/TCTCCT 1 -- int10--------
    rs1154474441,2
    C,F--43150324(+) CTCCTC/GCTATC 1 -- int11Minor allele frequency- G:0.05WA 118

    HapMap Linkage Disequilibrium report for CUL9 (43149913 - 43192325 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CUL9:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671960CNV Deletion23128226
    dgv6839n71CNV Loss21882294
    nsv521730CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CUL9
    DNA2.0 Custom Variant and Variant Library Synthesis for CUL9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607489    OMIM disorders: --

    9 diseases for CUL9:    
    About MalaCards
    peyronie's disease    peyronies disease    brain cancer    fanconi's anemia
    tuberculosis    neuroblastoma    ovarian cancer    hypertension
    obesity

    1 disease from the University of Copenhagen DISEASES database for CUL9:
    Peyronie's disease

    CUL9 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Genetic Association Database (GAD): CUL9
    Human Genome Epidemiology (HuGE) Navigator: CUL9 (2 documents)

    Export disorders for CUL9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CUL9 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with CUL9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1. (PubMed id 10521492)1, 2, 3, 9 Moynihan T.P.... Robinson P.A. (J. Biol. Chem. 1999)
    2. PARC and CUL7 form atypical cullin RING ligase complexes. (PubMed id 17332328)1, 2, 3 Skaar J.R.... DeCaprio J.A. (Cancer Res. 2007)
    3. Parc: a cytoplasmic anchor for p53. (PubMed id 12526791)1, 2, 3 Nikolaev A.Y.... Gu W. (Cell 2003)
    4. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    5. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2 Ishikawa K.... Ohara O. (DNA Res. 1998)
    9. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    10. A strategy for modulation of enzymes in the ubiquitin system. (PubMed id 23287719)1 Ernst A.... Sidhu S.S. (Science 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23113 HGNC: 15982 AceView: PARC Ensembl:ENSG00000112659 euGenes: HUgn23113
    ECgene: CUL9 H-InvDB: CUL9

    (According to HUGE)
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    HUGE: KIAA0708

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CUL9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CUL9 gene:
    Search GeneIP for patents involving CUL9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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