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Aliases for CUL7 Gene

Aliases for CUL7 Gene

  • Cullin 7 2 3
  • KIAA0076 2 3 4
  • CUL-7 3 4
  • Cullin-7 3
  • DJ20C7.5 3
  • 3M1 3

External Ids for CUL7 Gene

Previous Symbols for CUL7 Gene

  • KIAA0076

Summaries for CUL7 Gene

Entrez Gene Summary for CUL7 Gene

  • The protein encoded by this gene is a component of an E3 ubiquitin-protein ligase complex. The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in this gene are a cause of 3M syndrome type 1 (3M1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

GeneCards Summary for CUL7 Gene

CUL7 (Cullin 7) is a Protein Coding gene. Diseases associated with CUL7 include 3-m syndrome 1 and 3-m syndrome, cul7-related. Among its related pathways are Class I MHC mediated antigen processing and presentation and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is ZZEF1.

UniProtKB/Swiss-Prot for CUL7 Gene

  • Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (PubMed:24793696). Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (PubMed:21572988, PubMed:24362026). Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development (PubMed:20139075). Does not promote polyubiquitination and proteasomal degradation of p53/TP53 (PubMed:16547496, PubMed:17332328). While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may be have additional functions.

Gene Wiki entry for CUL7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUL7 Gene

Genomics for CUL7 Gene

Genomic Location for CUL7 Gene

Start:
43,037,617 bp from pter
End:
43,053,950 bp from pter
Size:
16,334 bases
Orientation:
Minus strand

Genomic View for CUL7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CUL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUL7 Gene

Regulatory Elements for CUL7 Gene

Proteins for CUL7 Gene

  • Protein details for CUL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14999-CUL7_HUMAN
    Recommended name:
    Cullin-7
    Protein Accession:
    Q14999
    Secondary Accessions:
    • B4DYZ0
    • F5H0L1
    • Q5T654

    Protein attributes for CUL7 Gene

    Size:
    1698 amino acids
    Molecular mass:
    191161 Da
    Quaternary structure:
    • Component of the 3M complex, composed of core components CUL7, CCDC8 and OBSL1. Part of a Cul7-RING complex consisting of CUL7, RBX1, SKP1 and FBXW8. Interacts with a complex of SKP1 and FBXW8, but not with SKP1 alone. Interacts with CUL9; leading to inhibit CUL9 activity. Interacts with FBXW8; interaction is mutually exclusive of binding to CUL9 or p53/TP53. Interacts with p53/TP53; the interaction preferentially involves tetrameric and dimeric p53/TP53. The CUL7-CUL9 heterodimer seems to interact specifically with p53/TP53. Interacts with CUL1; the interactions seems to be mediated by FBXW8. Interacts with SV40 Large T antigen; this interaction seems to inhibit CUL7. Interacts with OBSL1.
    SequenceCaution:
    • Sequence=BAA07551.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CUL7 Gene

    Alternative splice isoforms for CUL7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CUL7 Gene

Proteomics data for CUL7 Gene at MOPED

Post-translational modifications for CUL7 Gene

  • According to a report, may not be neddylated despite the conserved consensus site for neddylation at Lys-1576.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys255 and Lys1431

Other Protein References for CUL7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CUL7 Gene

Domains for CUL7 Gene

UniProtKB/Swiss-Prot:

CUL7_HUMAN
Domain:
  • Contains 1 DOC domain.:
    • Q14999
Family:
  • Belongs to the cullin family.:
    • Q14999
genes like me logo Genes that share domains with CUL7: view

No data available for Gene Families for CUL7 Gene

Function for CUL7 Gene

Molecular function for CUL7 Gene

UniProtKB/Swiss-Prot Function: Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (PubMed:24793696). Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (PubMed:21572988, PubMed:24362026). Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development (PubMed:20139075). Does not promote polyubiquitination and proteasomal degradation of p53/TP53 (PubMed:16547496, PubMed:17332328). While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may be have additional functions.

Gene Ontology (GO) - Molecular Function for CUL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 17298945
GO:0031625 ubiquitin protein ligase binding IEA --
genes like me logo Genes that share ontologies with CUL7: view
genes like me logo Genes that share phenotypes with CUL7: view

Animal Models for CUL7 Gene

MGI Knock Outs for CUL7:

miRNA for CUL7 Gene

miRTarBase miRNAs that target CUL7

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CUL7 Gene

Localization for CUL7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CUL7 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Golgi apparatus. Note=Colocalizes with FBXW8 at the Golgi apparatus in neurons; localization to Golgi is mediated by OBSL1. During mitosis, localizes to the mitotic apparatus (PubMed:24793695). CCDC8 is required for centrosomal location (PubMed:24793695). {ECO:0000269 PubMed:24793695}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CUL7 Gene COMPARTMENTS Subcellular localization image for CUL7 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for CUL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005680 anaphase-promoting complex NAS 12481031
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA 21572988
genes like me logo Genes that share ontologies with CUL7: view

Pathways for CUL7 Gene

genes like me logo Genes that share pathways with CUL7: view

UniProtKB/Swiss-Prot Q14999-CUL7_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for CUL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IMP 24793695
GO:0000281 mitotic cytokinesis IMP 24793695
GO:0001570 vasculogenesis ISS --
GO:0001837 epithelial to mesenchymal transition IDA 20139075
GO:0001890 placenta development IDA 20139075
genes like me logo Genes that share ontologies with CUL7: view

Transcripts for CUL7 Gene

Unigene Clusters for CUL7 Gene

Cullin 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CUL7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10: -
SP11:
SP12: - -
SP13: -
SP14: -
SP15: - - - - - - - - - - - - - - - - - - - - - -
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

ExUns: 15a · 15b ^ 16 ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29a · 29b ·
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15: - - - - - - - - -
SP16: - -
SP17: -
SP18:
SP19:
SP20:
SP21:
SP22:

ExUns: 29c · 29d ^ 30a · 30b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

Relevant External Links for CUL7 Gene

GeneLoc Exon Structure for
CUL7
ECgene alternative splicing isoforms for
CUL7

Expression for CUL7 Gene

mRNA expression in normal human tissues for CUL7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CUL7 Gene

SOURCE GeneReport for Unigene cluster for CUL7 Gene Hs.520136

mRNA Expression by UniProt/SwissProt for CUL7 Gene

Q14999-CUL7_HUMAN
Tissue specificity: Highly expressed in fetal kidney and adult skeletal muscle. Also abundant in fetal brain, as well as in adult pancreas, kidney, placenta and heart. Detected in trophoblasts, lymphoblasts, osteoblasts, chondrocytes and skin fibroblasts.
genes like me logo Genes that share expressions with CUL7: view

Orthologs for CUL7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CUL7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CUL7 36
  • 99.57 (n)
  • 99.55 (a)
CUL7 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CUL7 36
  • 87.97 (n)
  • 87.32 (a)
CUL7 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CUL7 36
  • 88.57 (n)
  • 88.87 (a)
CUL7 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cul7 36
  • 81.46 (n)
  • 78.52 (a)
Cul7 16
Cul7 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 59 (a)
ManyToMany
-- 37
  • 41 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 51 (a)
ManyToMany
-- 37
  • 32 (a)
ManyToMany
-- 37
  • 49 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC680835 36
  • 82.64 (n)
  • 81.37 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 16 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 32 (a)
ManyToMany
-- 37
  • 42 (a)
ManyToMany
-- 37
  • 49 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CABZ01087282.1 37
  • 34 (a)
ManyToMany
CABZ01087282.2 37
  • 42 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 29 (a)
OneToMany
Species with no ortholog for CUL7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CUL7 Gene

ENSEMBL:
Gene Tree for CUL7 (if available)
TreeFam:
Gene Tree for CUL7 (if available)

Paralogs for CUL7 Gene

Paralogs for CUL7 Gene

Selected SIMAP similar genes for CUL7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CUL7: view

Variants for CUL7 Gene

Sequence variations from dbSNP and Humsavar for CUL7 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs915177 -- 43,051,567(-) AAGAT(A/C)TAGGG intron-variant
rs1079325 -- 43,047,968(-) GTTCA(C/T)AAATC intron-variant
rs2273917 -- 43,040,560(+) AGCTT(C/T)AGGAG synonymous-codon, reference
rs2273918 -- 43,045,924(+) CCAGA(C/T)AGAAG intron-variant
rs3749902 -- 43,044,932(-) ATAAC(A/G)TATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CUL7 Gene

Variant ID Type Subtype PubMed ID
nsv462927 CNV Loss 19166990
nsv462930 CNV Loss 19166990

Relevant External Links for CUL7 Gene

HapMap Linkage Disequilibrium report
CUL7
Human Gene Mutation Database (HGMD)
CUL7

Disorders for CUL7 Gene

(1) OMIM Diseases for CUL7 Gene (609577)

UniProtKB/Swiss-Prot

CUL7_HUMAN
  • 3M syndrome 1 (3M1) [MIM:273750]: An autosomal recessive disorder characterized by severe pre- and postnatal growth retardation, facial dysmorphism, large head circumference, and normal intelligence and endocrine function. Skeletal changes include long slender tubular bones and tall vertebral bodies. {ECO:0000269 PubMed:16142236, ECO:0000269 PubMed:17675530, ECO:0000269 PubMed:23018678}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for CUL7 Gene

Relevant External Links for CUL7

GeneTests
CUL7
GeneReviews
CUL7
genes like me logo Genes that share disorders with CUL7: view

Publications for CUL7 Gene

  1. CUL7: a DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. (PMID: 12481031) Dias D.C. … Pan Z.Q. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4 23
  2. Identification of mutations in CUL7 in 3-M syndrome. (PMID: 16142236) Huber C. … Cormier-Daire V. (Nat. Genet. 2005) 3 4 23
  3. Clinical, molecular and histopathological features of short stature syndrome with novel CUL7 mutation in Yakuts: new population isolate in Asia. (PMID: 17675530) Maksimova N. … Onodera O. (J. Med. Genet. 2007) 3 4 23
  4. Ubiquitin ligase cullin 7 induces epithelial-mesenchymal transition in human choriocarcinoma cells. (PMID: 20139075) Fu J. … Wang H. (J. Biol. Chem. 2010) 3 4 23
  5. Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis. (PMID: 12904573) Arai T. … DeCaprio J.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4

Products for CUL7 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CUL7
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CUL7
    • Block miRNA regulation of CUL7 using miScript Target Protectors
    • Addgene plasmids for CUL7

    Sources for CUL7 Gene

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