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Aliases for CUL5 Gene

Aliases for CUL5 Gene

  • Cullin 5 2 3
  • VACM1 3 4 6
  • Vasopressin-Activated Calcium-Mobilizing Receptor 1 3 4
  • VACM-1 3 4
  • CUL-5 3 4
  • Cullin-5 (Vasopressin-Activated Calcium-Mobilizing Receptor-1) 3
  • Vasopressin-Activated Calcium-Mobilizing Receptor-1 3
  • Cullin-5 3

External Ids for CUL5 Gene

Summaries for CUL5 Gene

GeneCards Summary for CUL5 Gene

CUL5 (Cullin 5) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by GPCR. GO annotations related to this gene include receptor activity and calcium channel activity. An important paralog of this gene is CUL1.

UniProtKB/Swiss-Prot for CUL5 Gene

  • Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor

Gene Wiki entry for CUL5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUL5 Gene

Genomics for CUL5 Gene

Genomic Location for CUL5 Gene

Start:
108,008,682 bp from pter
End:
108,107,776 bp from pter
Size:
99,095 bases
Orientation:
Plus strand

Genomic View for CUL5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CUL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUL5 Gene

Regulatory Elements for CUL5 Gene

Proteins for CUL5 Gene

  • Protein details for CUL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93034-CUL5_HUMAN
    Recommended name:
    Cullin-5
    Protein Accession:
    Q93034
    Secondary Accessions:
    • A8K960
    • O14766
    • Q9BZC6

    Protein attributes for CUL5 Gene

    Size:
    780 amino acids
    Molecular mass:
    90955 Da
    Quaternary structure:
    • Component of multiple ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes formed of CUL5, Elongin BC (TCEB1 and TCEB2), RBX2 and a variable SOCS box domain-containing protein as substrate-specific recognition component. Component of the probable ECS(LRRC41) complex with the substrate recognition component LRRC41. Component of the probable ECS(SOCS1) complex with the substrate recognition component SOCS1. Component of the probable ECS(WSB1) complex with the substrate recognition subunit WSB1. Component of the probable ECS(SOCS3) complex with the substrate recognition component SOCS3. Component of the probable ECS(SPSB1) complex with the substrate recognition component SPSB1. Component of the probable ECS(SPSB2) complex with the substrate recognition component SPSB2. Component of the probable ECS(SPSB4) complex with the substrate recognition component SPSB4. Component of the probable ECS(RAB40C) complex with the substrate recognition subunit RAB40C. May also form complexes containing CUL5, elongin BC complex (TCEB1 and TCEB2), RBX1 and TCEB3. May also form complexes containing CUL5, Elongin BC (TCEB1 and TCEB2), RBX1 and VHL. The substrate recognition component can also be a viral protein such as HIV Vif, or human adenovirus 5 E1B large T-antigen and E4-orf6. Interacts with RNF7/RBX2, LRRC41, SOCS3, SPSB1, SPSB2, SPSB4 and RAB40C. Interacts with ASB1, ASB2, ASB6, ASB7 and ASB12.

    Three dimensional structures from OCA and Proteopedia for CUL5 Gene

neXtProt entry for CUL5 Gene

Proteomics data for CUL5 Gene at MOPED

Post-translational modifications for CUL5 Gene

  • Neddylated; which enhances the ubiquitination activity of SCF and prevents binding of the inhibitor CAND1. Deneddylated via its interaction with the COP9 signalosome (CSN).
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys384, Lys529, and Lys724

Other Protein References for CUL5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CUL5 Gene

Domains for CUL5 Gene

UniProtKB/Swiss-Prot:

CUL5_HUMAN
Family:
  • Belongs to the cullin family.:
    • Q93034
genes like me logo Genes that share domains with CUL5: view

No data available for Gene Families for CUL5 Gene

Function for CUL5 Gene

Molecular function for CUL5 Gene

GENATLAS Biochemistry: cullin 5,widely expressed,C elegans,cullin Cdc53 (CUL) family member,negative regulator of cell cycle
UniProtKB/Swiss-Prot Function: Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor

Gene Ontology (GO) - Molecular Function for CUL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9581826
GO:0005262 calcium channel activity TAS 9581826
GO:0005515 protein binding IPI 12504025
GO:0031625 ubiquitin protein ligase binding IDA 17636018
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with CUL5: view

Phenotypes for CUL5 Gene

GenomeRNAi human phenotypes for CUL5:
genes like me logo Genes that share phenotypes with CUL5: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CUL5 Gene

Localization for CUL5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CUL5 Gene COMPARTMENTS Subcellular localization image for CUL5 gene
Compartment Confidence
cytosol 4
nucleus 2
plasma membrane 2
extracellular 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CUL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0031461 cullin-RING ubiquitin ligase complex --
genes like me logo Genes that share ontologies with CUL5: view

Pathways for CUL5 Gene

genes like me logo Genes that share pathways with CUL5: view

UniProtKB/Swiss-Prot Q93034-CUL5_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for CUL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS 8681378
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0006970 response to osmotic stress IEA --
GO:0007050 cell cycle arrest TAS 8681378
GO:0008283 cell proliferation TAS 9037604
genes like me logo Genes that share ontologies with CUL5: view

Compounds for CUL5 Gene

(1) HMDB Compounds for CUL5 Gene

Compound Synonyms Cas Number PubMed IDs
Vasopressin
  • 3-(Phenylalanine)-8-lysine oxytocin
11000-17-2

(2) Novoseek inferred chemical compound relationships for CUL5 Gene

Compound -log(P) Hits PubMed IDs
acetylene 49.2 3
calcium 0 2
genes like me logo Genes that share compounds with CUL5: view

Transcripts for CUL5 Gene

Unigene Clusters for CUL5 Gene

Cullin 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CUL5 Gene

No ASD Table

Relevant External Links for CUL5 Gene

GeneLoc Exon Structure for
CUL5
ECgene alternative splicing isoforms for
CUL5

Expression for CUL5 Gene

mRNA expression in normal human tissues for CUL5 Gene

mRNA differential expression in normal tissues according to GTEx for CUL5 Gene

This gene is overexpressed in Muscle - Skeletal (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CUL5 Gene

SOURCE GeneReport for Unigene cluster for CUL5 Gene Hs.440320

genes like me logo Genes that share expressions with CUL5: view

Orthologs for CUL5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CUL5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CUL5 36
  • 99.83 (n)
  • 100 (a)
CUL5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CUL5 36
  • 96.03 (n)
  • 100 (a)
CUL5 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CUL5 36
  • 95.83 (n)
  • 99.87 (a)
CUL5 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cul5 36
  • 90.73 (n)
  • 98.46 (a)
Cul5 16
Cul5 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CUL5 37
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CUL5 37
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cul5 36
  • 91.28 (n)
  • 98.72 (a)
chicken
(Gallus gallus)
Aves CUL5 36
  • 87.26 (n)
  • 99.6 (a)
CUL5 37
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CUL5 37
  • 99 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14500 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cul5 36
  • 81.84 (n)
  • 98.85 (a)
Str.17488 36
zebrafish
(Danio rerio)
Actinopterygii cul5a 37
  • 97 (a)
OneToMany
cul5b 36
  • 78.89 (n)
  • 95 (a)
cul5b 37
  • 93 (a)
OneToMany
wufi20h12 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002404 36
  • 60.39 (n)
  • 72.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cul-5 36
  • 59.5 (n)
  • 67.1 (a)
Cul-5 37
  • 60 (a)
OneToOne
CG1401 38
  • 67 (a)
worm
(Caenorhabditis elegans)
Secernentea cul-5 36
  • 56.22 (n)
  • 52.78 (a)
cul-5 37
  • 52 (a)
OneToOne
cul-5 38
  • 49 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7070 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3614 37
  • 65 (a)
OneToOne
Species with no ortholog for CUL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CUL5 Gene

ENSEMBL:
Gene Tree for CUL5 (if available)
TreeFam:
Gene Tree for CUL5 (if available)

Paralogs for CUL5 Gene

Paralogs for CUL5 Gene

Selected SIMAP similar genes for CUL5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CUL5: view

Variants for CUL5 Gene

Sequence variations from dbSNP and Humsavar for CUL5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs15677 -- 108,106,762(+) CTCCA(A/G)CGTAC utr-variant-3-prime
rs1052608 -- 108,104,497(+) TATTA(A/C)AATCT utr-variant-3-prime
rs1052609 -- 108,104,498(+) ATTAA(A/C)ATCTC utr-variant-3-prime
rs1052612 -- 108,106,703(+) TACCA(C/G)CAGTT utr-variant-3-prime
rs2037312 -- 108,099,252(+) tgcct(C/G)cctcg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CUL5 Gene

Variant ID Type Subtype PubMed ID
nsv521771 CNV Gain 19592680
esv2750980 CNV Gain 17911159
esv2745050 CNV Deletion 23290073
nsv507616 CNV Insertion 20534489

Relevant External Links for CUL5 Gene

HapMap Linkage Disequilibrium report
CUL5
Human Gene Mutation Database (HGMD)
CUL5

Disorders for CUL5 Gene

(1) Novoseek inferred disease relationships for CUL5 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 2

Relevant External Links for CUL5

Genetic Association Database (GAD)
CUL5
Human Genome Epidemiology (HuGE) Navigator
CUL5
genes like me logo Genes that share disorders with CUL5: view

No data available for UniProtKB/Swiss-Prot for CUL5 Gene

Publications for CUL5 Gene

  1. Identification and analysis of expression of human VACM-1, a cullin gene family member located on chromosome 11q22-23. (PMID: 9037604) Byrd P.J. … Taylor A.M.R. (Genome Res. 1997) 2 3 4 23
  2. Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery. (PMID: 12186903) Harada J.N. … Berk A.J. (J. Virol. 2002) 3 4 23
  3. Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation. (PMID: 15574592) Mehle A. … Gabuzda D. (Genes Dev. 2004) 3 4 23
  4. Polymorphisms of CUL5 are associated with CD4+ T cell loss in HIV-1 infected individuals. (PMID: 17257057) An P. … Winkler C.A. (PLoS Genet. 2007) 3 23 49
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CUL5 Gene

  • Addgene plasmids for CUL5

Sources for CUL5 Gene

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