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CUL5 Gene

protein-coding   GIFtS: 65
GCID: GC11P107913

Cullin 5

  See CUL5-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cullin 51 2     VACM-12 3
VACM12 3 5     cullin-52
Vasopressin-Activated Calcium-Mobilizing Receptor 12 3     Cullin-5 (Vasopressin-Activated Calcium-Mobilizing Receptor-1)2
CUL-52 3     Vasopressin-Activated Calcium-Mobilizing Receptor-12

External Ids:    HGNC: 25561   Entrez Gene: 80652   Ensembl: ENSG000001662667   OMIM: 6017415   UniProtKB: Q930343   

Export aliases for CUL5 gene to outside databases

Previous GC identifers: GC11P110074 GC11P109236 GC11P107417 GC11P107384 GC11P103804


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CUL5 Gene:
CUL5 (cullin 5) is a protein-coding gene. Diseases associated with CUL5 include glomuvenous malformation. GO annotations related to this gene include calcium channel activity and receptor activity. An important paralog of this gene is CUL1.

UniProtKB/Swiss-Prot: CUL5_HUMAN, Q93034
Function: Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein
ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As
a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating
enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate
recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal
degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor

Gene Wiki entry for CUL5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CUL5 gene promoter:
         ER-alpha   AhR   C/EBPalpha   Arnt   YY1   CHOP-10   N-Myc   Zic1   ARP-1   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCUL5 promoter sequence
   Search Chromatin IP Primers for CUL5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CUL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.3   Ensembl cytogenetic band:  11q22.3   HGNC cytogenetic band: 11q22.3

CUL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CUL5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P107913:  view genomic region     (about GC identifiers)

Start:
107,879,408 bp from pter      End:
107,978,503 bp from pter
Size:
99,096 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CUL5_HUMAN, Q93034 (See protein sequence)
Recommended Name: Cullin-5  
Size: 780 amino acids; 90955 Da
Subunit: Component of multiple ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes
formed of CUL5, Elongin BC (TCEB1 and TCEB2), RBX2 and a variable SOCS box domain-containing protein as
substrate-specific recognition component. Component of the probable ECS(LRRC41) complex with the substrate
recognition component LRRC41. Component of the probable ECS(SOCS1) complex with the substrate recognition
component SOCS1. Component of the probable ECS(WSB1) complex with the substrate recognition subunit WSB1.
Component of the probable ECS(SOCS3) complex with the substrate recognition component SOCS3. Component of the
probable ECS(SPSB1) complex with the substrate recognition component SPSB1. Component of the probable ECS(SPSB2)
complex with the substrate recognition component SPSB2. Component of the probable ECS(SPSB4) complex with the
substrate recognition component SPSB4. Component of the probable ECS(RAB40C) complex with the substrate
recognition subunit RAB40C. May also form complexes containing CUL5, elongin BC complex (TCEB1 and TCEB2), RBX1
and TCEB3. May also form complexes containing CUL5, Elongin BC (TCEB1 and TCEB2), RBX1 and VHL. The substrate
recognition component can also be a viral protein such as HIV Vif, or human adenovirus 5 E1B large T-antigen and
E4-orf6. Interacts with RNF7/RBX2, LRRC41, SOCS3, SPSB1, SPSB2, SPSB4 and RAB40C. Interacts with ASB1, ASB2,
ASB6, ASB7 and ASB12
4 PDB 3D structures from and Proteopedia for CUL5:
3DPL (3D)        3DQV (3D)        4JGH (3D)        4N9F (3D)    
Secondary accessions: A8K960 O14766 Q9BZC6

Explore the universe of human proteins at neXtProt for CUL5: NX_Q93034

Explore proteomics data for CUL5 at MOPED

Post-translational modifications: 

  • Neddylated; which enhances the ubiquitination activity of SCF and prevents binding of the inhibitor CAND1.
    Deneddylated via its interaction with the COP9 signalosome (CSN)1
  • Ubiquitination2 at Lys384, Lys529, Lys724
  • Modification sites at PhosphoSitePlus

  • See CUL5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003469.2  
    ENSEMBL proteins: 
     ENSP00000376808   ENSP00000436494   ENSP00000435376   ENSP00000431221  
    Reactome Protein details: Q93034

    CUL5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for CUL5
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CUL5
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    Novus Biologicals CUL5 Protein
    Novus Biologicals CUL5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CUL5

     
    Search eBioscience for Proteins for CUL5 

     
    antibodies-online proteins for CUL5 (5 products) 

     
    antibodies-online peptides for CUL5

    CUL5 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CUL5
    Browse R&D Systems for Antibodies
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    Abcam antibodies for CUL5
    Cloud-Clone Corp. Antibodies for CUL5
    ThermoFisher Antibody for CUL5
    antibodies-online antibodies for CUL5 (50 products) 

    CUL5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CUL5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CUL5
    Cloud-Clone Corp. CLIAs for CUL5
    Search eBioscience for ELISAs for CUL5 
    antibodies-online kits for CUL5 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR016159 Cullin_repeat-like_dom
     IPR019559 Cullin_neddylation_domain
     IPR016157 Cullin_CS
     IPR001373 Cullin_N
     IPR011991 WHTH_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q93034

    ProtoNet protein and cluster: Q93034

    1 Blocks protein domain: IPB001373 Cullin

    UniProtKB/Swiss-Prot: CUL5_HUMAN, Q93034
    Similarity: Belongs to the cullin family


    Find genes that share domains with CUL5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CUL5_HUMAN, Q93034
    Function: Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein
    ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As
    a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating
    enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate
    recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal
    degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor

         Genatlas biochemistry entry for CUL5:
    cullin 5,widely expressed,C elegans,cullin Cdc53 (CUL) family member,negative regulator of cell cycle

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS9581826
    GO:0005262calcium channel activity TAS9581826
    GO:0005515protein binding IPI12504025
    GO:0031625ubiquitin protein ligase binding IDA17636018
         
    Find genes that share ontologies with CUL5           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CUL5:
     Decreased nuclei size in G2M  Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CUL5

    miRNA
    Products:
        
    miRTarBase miRNAs that target CUL5:
    hsa-mir-215-5p (MIRT024359), hsa-mir-484 (MIRT042216), hsa-mir-148b-3p (MIRT019403), hsa-mir-192-5p (MIRT004846), hsa-mir-375 (MIRT019963), hsa-mir-19b-3p (MIRT006476), hsa-mir-100-5p (MIRT048574), hsa-mir-19a-3p (MIRT006475), hsa-mir-92a-3p (MIRT049218)

    Block miRNA regulation of human, mouse, rat CUL5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CUL5 (see all 76):
    hsa-miR-411* hsa-miR-3607-3p hsa-miR-300 hsa-miR-508-5p hsa-miR-200b hsa-miR-3622a-5p hsa-miR-3667-3p hsa-miR-152
    SwitchGear 3'UTR luciferase reporter plasmidCUL5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CUL5
    Predesigned siRNA for gene silencing in human, mouse, rat CUL5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CUL5

    Clone
    Products:
         
    OriGene clones in human, mouse for CUL5 (see all 7)
    OriGene ORF clones in mouse, rat for CUL5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CUL5 (NM_003478)
    Sino Biological Human cDNA Clone for CUL5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CUL5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUL5
    Addgene plasmids for CUL5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CUL5
    Browse ESI BIO Cell Lines and PureStem Progenitors for CUL5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUL5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    plasma membrane2
    extracellular1
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--
    GO:0031461cullin-RING ubiquitin ligase complex ----

    Find genes that share ontologies with CUL5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CUL5 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    2HIV Life Cycle
    HIV Infection0.62
    Host Interactions of HIV factors0.60
    3Signaling by FGFR
    Signaling by ERBB20.89
    4CDK-mediated phosphorylation and removal of Cdc6
    Vif-mediated degradation of APOBEC3G0.86
    5Signaling by GPCR
    Signal Transduction0.58


    Find genes that share SuperPaths with CUL5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3 Reactome Pathways for CUL5
        Vif-mediated degradation of APOBEC3G
    Signaling by ERBB2
    Antigen processing: Ubiquitination & Proteasome degradation


    1 Kegg Pathway  (Kegg details for CUL5):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: CUL5_HUMAN, Q93034
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CUL5: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CUL5

    Selected Interacting proteins for CUL5 (Q930341, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 134)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASB2Q96Q271, 2, 3EBI-1057139,EBI-2880677 MINT-75029 MINT-77968 MINT-1786035 MINT-7986036 I2D: score=2 
    RBX1P628771, 3EBI-1057139,EBI-398523 I2D: score=5 
    SMAD2Q157962, 3MINT-61623 I2D: score=3 
    ASB1Q9Y5762, 3MINT-77970 I2D: score=2 
    ASB12Q8WXK42, 3MINT-77976 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS8681378
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0006970response to osmotic stress IEA--
    GO:0007050cell cycle arrest TAS8681378
    GO:0008283cell proliferation TAS9037604

    Find genes that share ontologies with CUL5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CUL5

    1 HMDB Compound for CUL5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Vasopressin3-(Phenylalanine)-8-lysine oxytocin (see all 8)11000-17-2--

    2 Novoseek inferred chemical compound relationships for CUL5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acetylene 49.2 3 16636053 (3)
    calcium 0 4 17186378 (1), 15762197 (1)



    Find genes that share compounds with CUL5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CUL5 gene: 
    NM_003478.3  

    Unigene Cluster for CUL5:

    Cullin 5
    Hs.440320  [show with all ESTs]
    Unigene Representative Sequence: NM_003478
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393094(uc001pju.3 uc001pjv.3) ENST00000532064 ENST00000526303
    ENST00000531427 ENST00000532782 ENST00000531843
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CUL5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CUL5 (see all 76):
    hsa-miR-411* hsa-miR-3607-3p hsa-miR-300 hsa-miR-508-5p hsa-miR-200b hsa-miR-3622a-5p hsa-miR-3667-3p hsa-miR-152
    SwitchGear 3'UTR luciferase reporter plasmidCUL5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CUL5
    Predesigned siRNA for gene silencing in human, mouse, rat CUL5
    Clone
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    OriGene clones in human, mouse for CUL5 (see all 7)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CUL5 (NM_003478)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CUL5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUL5
    Addgene plasmids for CUL5 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CUL5
    OriGene qSTAR qPCR primer pairs in human, mouse for CUL5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CUL5
      QuantiTect SYBR Green Assays in human, mouse, rat CUL5
      QuantiFast Probe-based Assays in human, mouse, rat CUL5

    Additional mRNA sequence: 

    AF017061.1 AF327710.1 AK125294.1 AK292575.1 BC017838.1 BC037203.1 BC063306.1 X81882.1 

    10 DOTS entries:

    DT.441965  DT.442301  DT.120707182  DT.97789810  DT.100748383  DT.120707136  DT.120707137  DT.97823023 
    DT.100680560  DT.40131194 

    Selected AceView cDNA sequences (see all 165):

    AI688961 BE674758 BX499523 AA505090 AI382810 AW268641 BM472371 BQ576268 
    BX097158 AI619822 AK125294 AA788673 AW303561 AI674090 BU784350 AA972127 
    BU633592 AA403250 AA804245 AI376842 AA732467 AI292184 AF327710 CB053708 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CUL5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGCTTTCC
    CUL5 Expression
    About this image

    CUL5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CUL5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.440320
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CUL5: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CUL5
    OriGene qSTAR qPCR primer pairs in human, mouse for CUL5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CUL5
    QuantiTect SYBR Green Assays in human, mouse, rat CUL5
    QuantiFast Probe-based Assays in human, mouse, rat CUL5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUL5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CUL5 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cul51 , 5 cullin 51, 5 90.73(n)1
    98.46(a)1
      9 (29.12 cM)5
    757171  NM_027807.31  NP_082083.21 
     536145825 
    chicken
    (Gallus gallus)
    Aves CUL51 cullin 5 87.26(n)
    99.6(a)
      418969  XM_417163.4  XP_417163.4 
    lizard
    (Anolis carolinensis)
    Reptilia CUL56
    cullin 5
    99(a)
    1 ↔ 1
    GL343659.1(194347-239292)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.145002 Xenopus laevis transcribed sequence with strong similarity more 80.17(n)    BJ042671.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi20h122 Danio rerio Vasopressin-activated calcium-mobilizing more 78.76(n)    BC057475.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG14013
    Cul-51
    vasopressin activated calcium
    mobilizing receptor3
    Cullin-51
    67(a)3
    59.5(n)1
    67.1(a)1
      98F63
    434341  NM_143408.21  NP_651665.21 
    worm
    (Caenorhabditis elegans)
    Secernentea cul-51 , 3 Cullin family3
    cul-51
    49(a)3
    56.22(n)1
    52.78(a)1
      V(10182152-10185480)3
    1794131  NM_073215.41  NP_505616.21 


    ENSEMBL Gene Tree for CUL5 (if available)
    TreeFam Gene Tree for CUL5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CUL5 gene
    CUL12  CUL32  CUL4A2  CUL4B2  CUL22  
    2 SIMAP similar genes for CUL5 using alignment to 5 protein entries:     CUL5_HUMAN (see all proteins):
    CUL1    CUL2

    Find genes that share paralogs with CUL5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CUL5 (see all 1938)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1902555711,2
    --107877412(+) GTGGCA/GCAATC 1 -- us2k10--------
    rs1830288081,2
    --107877763(+) GTAGCA/GTTAAA 1 -- us2k10--------
    rs1871297481,2
    --107877842(+) ATAGCA/GATAGC 1 -- us2k10--------
    rs1919107191,2
    --107877859(+) GCACAG/TGCTGG 1 -- us2k10--------
    rs755827931,2
    F--107877861(+) ACAGGC/TTGGTC 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1143782121,2
    C,F--107877869(+) GTCTCG/CAACCC 1 -- us2k11Minor allele frequency- C:0.08WA 118
    rs1442689361,2
    --107877951(+) GCTGAA/CATGCA 1 -- us2k10--------
    rs797135001,2
    C--107878032(+) ATATAA/GAACAT 1 -- us2k10--------
    rs1179539011,2
    F--107878115(+) TATGTG/ACCTGC 1 -- us2k11Minor allele frequency- A:0.02EA 120
    rs1417327541,2
    --107878269(+) AAGTCA/GGAGTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CUL5 (107879408 - 107978503 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CUL5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745050CNV Deletion23290073
    nsv507616CNV Insertion20534489
    esv2750980CNV Gain17911159
    nsv521771CNV Gain19592680

    Human Gene Mutation Database (HGMD): CUL5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CUL5
    DNA2.0 Custom Variant and Variant Library Synthesis for CUL5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601741    OMIM disorders: --

    1 disease for CUL5:    
    About MalaCards
    glomuvenous malformation


    Find genes that share disorders with CUL5           About GenesLikeMe

    1 Novoseek inferred disease relationship for CUL5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 5 12878869 (1), 19147357 (1)

    Genetic Association Database (GAD): CUL5
    Human Genome Epidemiology (HuGE) Navigator: CUL5 (1 document)

    Export disorders for CUL5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CUL5 gene, integrated from 10 sources (see all 145):
    (articles sorted by number of sources associating them with CUL5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and analysis of expression of human VACM-1, a cullin gene family member located on chromosome 11q22-23. (PubMed id 9037604)1, 2, 3, 9 Byrd P.J....Taylor A.M.R. (Genome Res. 1997)
    2. Polymorphisms of CUL5 are associated with CD4+ T cell loss in HIV-1 infected individuals. (PubMed id 17257057)1, 4, 9 An P....Winkler C.A. (PLoS Genet. 2007)
    3. Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery. (PubMed id 12186903)1, 2, 9 Harada J.N.... Berk A.J. (J. Virol. 2002)
    4. Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation. (PubMed id 15574592)1, 2, 9 Mehle A.... Gabuzda D. (Genes Dev. 2004)
    5. Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation. (PubMed id 18805092)1, 2 Duda D.M....Schulman B.A. (Cell 2008)
    6. ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. (PubMed id 16325183)1, 2 Kohroki J.... Masuho Y. (FEBS Lett. 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. VHL-box and SOCS-box domains determine binding specificity for Cul2- Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. (PubMed id 15601820)1, 2 Kamura T.... Nakayama K.I. (Genes Dev. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Muf1, a novel elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase. (PubMed id 11384984)1, 2 Kamura T.... Conaway J.W. (J. Biol. Chem. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8065 HGNC: 2556 AceView: CUL5 Ensembl:ENSG00000166266 euGenes: HUgn8065
    ECgene: CUL5 Kegg: 8065 H-InvDB: CUL5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CUL5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CUL5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CUL5 gene:
    Search GeneIP for patents involving CUL5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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