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Aliases for CUL5 Gene

Aliases for CUL5 Gene

  • Cullin 5 2 3 5
  • Vasopressin-Activated Calcium-Mobilizing Receptor 1 3 4
  • VACM-1 3 4
  • CUL-5 3 4
  • VACM1 3 4
  • Cullin-5 (Vasopressin-Activated Calcium-Mobilizing Receptor-1) 3
  • Vasopressin-Activated Calcium-Mobilizing Receptor-1 3

External Ids for CUL5 Gene

Previous GeneCards Identifiers for CUL5 Gene

  • GC11P110074
  • GC11P109236
  • GC11P107913
  • GC11P107417
  • GC11P107384
  • GC11P103804

Summaries for CUL5 Gene

GeneCards Summary for CUL5 Gene

CUL5 (Cullin 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include protein heterodimerization activity and ubiquitin protein ligase binding. An important paralog of this gene is CUL1.

UniProtKB/Swiss-Prot for CUL5 Gene

  • Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.

Gene Wiki entry for CUL5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUL5 Gene

Genomics for CUL5 Gene

Regulatory Elements for CUL5 Gene

Promoters for CUL5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CUL5 on UCSC Golden Path with GeneCards custom track

Genomic Location for CUL5 Gene

Chromosome:
11
Start:
108,008,682 bp from pter
End:
108,107,776 bp from pter
Size:
99,095 bases
Orientation:
Plus strand

Genomic View for CUL5 Gene

Genes around CUL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CUL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CUL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUL5 Gene

Proteins for CUL5 Gene

  • Protein details for CUL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93034-CUL5_HUMAN
    Recommended name:
    Cullin-5
    Protein Accession:
    Q93034
    Secondary Accessions:
    • A8K960
    • O14766
    • Q9BZC6

    Protein attributes for CUL5 Gene

    Size:
    780 amino acids
    Molecular mass:
    90955 Da
    Quaternary structure:
    • Component of multiple ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes formed of CUL5, Elongin BC (TCEB1 and TCEB2), RBX2 and a variable SOCS box domain-containing protein as substrate-specific recognition component. Component of the probable ECS(LRRC41) complex with the substrate recognition component LRRC41. Component of the probable ECS(SOCS1) complex with the substrate recognition component SOCS1. Component of the probable ECS(WSB1) complex with the substrate recognition subunit WSB1. Component of the probable ECS(SOCS3) complex with the substrate recognition component SOCS3. Component of the probable ECS(SPSB1) complex with the substrate recognition component SPSB1. Component of the probable ECS(SPSB2) complex with the substrate recognition component SPSB2. Component of the probable ECS(SPSB4) complex with the substrate recognition component SPSB4. Component of the probable ECS(RAB40C) complex with the substrate recognition subunit RAB40C. May also form complexes containing CUL5, elongin BC complex (TCEB1 and TCEB2), RBX1 and TCEB3. May also form complexes containing CUL5, Elongin BC (TCEB1 and TCEB2), RBX1 and VHL. The substrate recognition component can also be a viral protein such as HIV Vif, or human adenovirus 5 E1B large T-antigen and E4-orf6. Interacts with RNF7/RBX2, LRRC41, SOCS3, SPSB1, SPSB2, SPSB4 and RAB40C. Interacts with ASB1, ASB2, ASB6, ASB7 and ASB12.

    Three dimensional structures from OCA and Proteopedia for CUL5 Gene

neXtProt entry for CUL5 Gene

Proteomics data for CUL5 Gene at MOPED

Post-translational modifications for CUL5 Gene

  • Neddylated; which enhances the ubiquitination activity of SCF and prevents binding of the inhibitor CAND1. Deneddylated via its interaction with the COP9 signalosome (CSN).
  • Ubiquitination at Lys 384, Lys 529, and Lys 724
  • Modification sites at PhosphoSitePlus

Other Protein References for CUL5 Gene

Antibody Products

No data available for DME Specific Peptides for CUL5 Gene

Domains & Families for CUL5 Gene

Gene Families for CUL5 Gene

Suggested Antigen Peptide Sequences for CUL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q93034

UniProtKB/Swiss-Prot:

CUL5_HUMAN :
  • Belongs to the cullin family.
Family:
  • Belongs to the cullin family.
genes like me logo Genes that share domains with CUL5: view

Function for CUL5 Gene

Molecular function for CUL5 Gene

GENATLAS Biochemistry:
cullin 5,widely expressed,C elegans,cullin Cdc53 (CUL) family member,negative regulator of cell cycle
UniProtKB/Swiss-Prot Function:
Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.

Gene Ontology (GO) - Molecular Function for CUL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9581826
genes like me logo Genes that share ontologies with CUL5: view
genes like me logo Genes that share phenotypes with CUL5: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CUL5 Gene

Localization for CUL5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CUL5 Gene COMPARTMENTS Subcellular localization image for CUL5 gene
Compartment Confidence
cytosol 5
nucleus 3
golgi apparatus 2
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CUL5 Gene

Pathways & Interactions for CUL5 Gene

genes like me logo Genes that share pathways with CUL5: view

Pathways by source for CUL5 Gene

1 GeneTex pathway for CUL5 Gene
1 KEGG pathway for CUL5 Gene
1 R&D Systems pathway for CUL5 Gene

UniProtKB/Swiss-Prot Q93034-CUL5_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for CUL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest TAS 8681378
GO:0016032 viral process IEA,TAS --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
GO:0070588 calcium ion transmembrane transport TAS 9581826
GO:0097193 intrinsic apoptotic signaling pathway TAS 9581826
genes like me logo Genes that share ontologies with CUL5: view

No data available for SIGNOR curated interactions for CUL5 Gene

Drugs & Compounds for CUL5 Gene

(2) Drugs for CUL5 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vasopressin Approved Pharma Full agonist, Agonist 0

(1) Additional Compounds for CUL5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CUL5: view

Transcripts for CUL5 Gene

Unigene Clusters for CUL5 Gene

Cullin 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CUL5 Gene

No ASD Table

Relevant External Links for CUL5 Gene

GeneLoc Exon Structure for
CUL5
ECgene alternative splicing isoforms for
CUL5

Expression for CUL5 Gene

mRNA expression in normal human tissues for CUL5 Gene

mRNA differential expression in normal tissues according to GTEx for CUL5 Gene

This gene is overexpressed in Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for CUL5 Gene

This gene is overexpressed in Lymph node (8.3) and Uterus (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CUL5 Gene



SOURCE GeneReport for Unigene cluster for CUL5 Gene Hs.440320

genes like me logo Genes that share expression patterns with CUL5: view

Protein tissue co-expression partners for CUL5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CUL5 Gene

Orthologs for CUL5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CUL5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CUL5 35
  • 96.03 (n)
  • 100 (a)
CUL5 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CUL5 35
  • 95.83 (n)
  • 99.87 (a)
CUL5 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cul5 35
  • 90.73 (n)
  • 98.46 (a)
Cul5 16
Cul5 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CUL5 35
  • 99.83 (n)
  • 100 (a)
CUL5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cul5 35
  • 91.28 (n)
  • 98.72 (a)
oppossum
(Monodelphis domestica)
Mammalia CUL5 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CUL5 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves CUL5 35
  • 87.26 (n)
  • 99.6 (a)
CUL5 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CUL5 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cul5 35
  • 81.84 (n)
  • 98.85 (a)
Str.17488 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.14500 35
zebrafish
(Danio rerio)
Actinopterygii cul5b 35
  • 78.89 (n)
  • 95 (a)
wufi20h12 35
cul5a 36
  • 97 (a)
OneToMany
cul5b 36
  • 93 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1401 37
  • 67 (a)
Cul-5 35
  • 59.5 (n)
  • 67.1 (a)
Cul-5 36
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002404 35
  • 60.39 (n)
  • 72.6 (a)
worm
(Caenorhabditis elegans)
Secernentea cul-5 37
  • 49 (a)
cul-5 35
  • 56.22 (n)
  • 52.78 (a)
cul-5 36
  • 52 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7070 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3614 36
  • 65 (a)
OneToOne
Species with no ortholog for CUL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CUL5 Gene

ENSEMBL:
Gene Tree for CUL5 (if available)
TreeFam:
Gene Tree for CUL5 (if available)

Paralogs for CUL5 Gene

Paralogs for CUL5 Gene

(2) SIMAP similar genes for CUL5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CUL5: view

Variants for CUL5 Gene

Sequence variations from dbSNP and Humsavar for CUL5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs15677 -- 108,106,762(+) CTCCA(A/G)CGTAC utr-variant-3-prime
rs1052608 -- 108,104,497(+) TATTA(A/C)AATCT utr-variant-3-prime
rs1052609 -- 108,104,498(+) ATTAA(A/C)ATCTC utr-variant-3-prime
rs1052612 -- 108,106,703(+) TACCA(C/G)CAGTT utr-variant-3-prime
rs2271852 -- 108,054,576(+) TATTT(A/G)TTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CUL5 Gene

Variant ID Type Subtype PubMed ID
nsv521771 CNV Gain 19592680
esv2750980 CNV Gain 17911159
esv2745050 CNV Deletion 23290073
nsv507616 CNV Insertion 20534489

Variation tolerance for CUL5 Gene

Residual Variation Intolerance Score: 9.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CUL5 Gene

HapMap Linkage Disequilibrium report
CUL5
Human Gene Mutation Database (HGMD)
CUL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CUL5 Gene

Disorders for CUL5 Gene

Relevant External Links for CUL5

Genetic Association Database (GAD)
CUL5
Human Genome Epidemiology (HuGE) Navigator
CUL5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CUL5

No disorders were found for CUL5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CUL5 Gene

Publications for CUL5 Gene

  1. Identification and analysis of expression of human VACM-1, a cullin gene family member located on chromosome 11q22-23. (PMID: 9037604) Byrd P.J. … Taylor A.M.R. (Genome Res. 1997) 2 3 4 23 67
  2. Regulation of APOBEC3 proteins by a novel YXXL motif in human immunodeficiency virus type 1 Vif and simian immunodeficiency virus SIVagm Vif. (PMID: 19109396) Pery E. … Gabuzda D. (J. Virol. 2009) 3 23
  3. Granulocytic differentiation of HL-60 promyelocytic leukemia cells is associated with increased expression of Cul5. (PMID: 19118439) Baxter S.S. … Fay M.J. (In Vitro Cell. Dev. Biol. Anim. 2009) 3 23
  4. Characterization of Cullin-box sequences that direct recruitment of Cul2-Rbx1 and Cul5-Rbx2 modules to Elongin BC-based ubiquitin ligases. (PMID: 18187417) Mahrour N. … Conaway J.W. (J. Biol. Chem. 2008) 3 23
  5. E4Orf6-E1B-55k-dependent degradation of de novo-generated adeno-associated virus type 5 Rep52 and capsid proteins employs a cullin 5-containing E3 ligase complex. (PMID: 18216112) Nayak R. … Pintel D.J. (J. Virol. 2008) 3 23

Products for CUL5 Gene

Sources for CUL5 Gene

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