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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CUL5 Gene

protein-coding   GIFtS: 65
GCID: GC11P107913

Cullin 5

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cullin 51 2     VACM-12 3
VACM12 3 5     cullin-52
Vasopressin-Activated Calcium-Mobilizing Receptor 12 3     Cullin-5 (Vasopressin-Activated Calcium-Mobilizing Receptor-1)2
CUL-52 3     Vasopressin-Activated Calcium-Mobilizing Receptor-12

External Ids:    HGNC: 25561   Entrez Gene: 80652   Ensembl: ENSG000001662667   OMIM: 6017415   UniProtKB: Q930343   

Export aliases for CUL5 gene to outside databases

Previous GC identifers: GC11P110074 GC11P109236 GC11P107417 GC11P107384 GC11P103804


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CUL5 Gene: 
CUL5 (cullin 5) is a protein-coding gene. Diseases associated with CUL5 include glomuvenous malformation, and rabies, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and HIV Infection. GO annotations related to this gene include calcium channel activity and receptor activity. An important paralog of this gene is CUL1.

UniProtKB/Swiss-Prot: CUL5_HUMAN, Q93034
Function: Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein
ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As
a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating
enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate
recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. Seems to be involved poteosomal
degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor

Gene Wiki entry for CUL5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CUL5 gene promoter:
         ER-alpha   AhR   C/EBPalpha   Arnt   YY1   CHOP-10   N-Myc   Zic1   ARP-1   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCUL5 promoter sequence
   Search SABiosciences Chromatin IP Primers for CUL5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CUL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.3   Ensembl cytogenetic band:  11q22.3   HGNC cytogenetic band: 11q22.3

CUL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CUL5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P107913:  view genomic region     (about GC identifiers)

Start:
107,879,408 bp from pter      End:
107,978,503 bp from pter
Size:
99,096 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CUL5_HUMAN, Q93034 (See protein sequence)
Recommended Name: Cullin-5  
Size: 780 amino acids; 90955 Da
Subunit: Component of multiple ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes
formed of CUL5, Elongin BC (TCEB1 and TCEB2), RBX2 and a variable SOCS box domain-containing protein as
substrate-specific recognition component. Component of the probable ECS(LRRC41) complex with the substrate
recognition component LRRC41. Component of the probable ECS(SOCS1) complex with the substrate recognition
component SOCS1. Component of the probable ECS(WSB1) complex with the substrate recognition subunit WSB1.
Component of the probable ECS(SOCS3) complex with the substrate recognition component SOCS3. Component of the
probable ECS(SPSB1) complex with the substrate recognition component SPSB1. Component of the probable ECS(SPSB2)
complex with the substrate recognition component SPSB2. Component of the probable ECS(SPSB4) complex with the
substrate recognition component SPSB4. Component of the probable ECS(RAB40C) complex with the substrate
recognition subunit RAB40C. May also form complexes containing CUL5, elongin BC complex (TCEB1 and TCEB2), RBX1
and TCEB3. May also form complexes containing CUL5, Elongin BC (TCEB1 and TCEB2), RBX1 and VHL. The substrate
recognition component can also be a viral protein such as HIV Vif, or human adenovirus 5 E1B large T-antigen and
E4-orf6. Interacts with RNF7/RBX2, LRRC41, SOCS3, SPSB1, SPSB2, SPSB4 and RAB40C. Interacts with ASB1, ASB2,
ASB6, ASB7 and ASB12
2 PDB 3D structures from and Proteopedia for CUL5:
3DPL (3D)        3DQV (3D)    
Secondary accessions: A8K960 O14766 Q9BZC6

Explore the universe of human proteins at neXtProt for CUL5: NX_Q93034

Explore proteomics data for CUL5 at MOPED 

Post-translational modifications:

  • UniProtKB: Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q93034

  • CUL5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CUL5 Protein Expression
    REFSEQ proteins: NP_003469.2  
    ENSEMBL proteins: 
     ENSP00000376808   ENSP00000436494   ENSP00000435376   ENSP00000431221  
    Reactome Protein details: Q93034
    Human Recombinant Protein Products for CUL5: 
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for CUL5
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    Novus Biologicals CUL5 Protein
    Novus Biologicals CUL5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CUL5 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--
    GO:0031461cullin-RING ubiquitin ligase complex ----

    CUL5 for ontologies           About GeneDecksing



    CUL5 Antibody Products: 
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    Abcam antibodies for CUL5
    Cloud-Clone Corp. Antibodies for CUL5 
    ThermoFisher Antibody for CUL5
    LSBio Antibodies in human, mouse, rat for CUL5 

    Assay Products for CUL5: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CUL5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CUL5 
    Cloud-Clone Corp. CLIAs for CUL5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR016159 Cullin_repeat-like_dom
     IPR019559 Cullin_neddylation_domain
     IPR016157 Cullin_CS
     IPR001373 Cullin_N
     IPR011991 WHTH_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q93034

    ProtoNet protein and cluster: Q93034

    1 Blocks protein domain: IPB001373 Cullin

    UniProtKB/Swiss-Prot: CUL5_HUMAN, Q93034
    Similarity: Belongs to the cullin family


    CUL5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CUL5_HUMAN, Q93034
    Function: Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein
    ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As
    a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating
    enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate
    recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. Seems to be involved poteosomal
    degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor

         Genatlas biochemistry entry for CUL5:
    cullin 5,widely expressed,C elegans,cullin Cdc53 (CUL) family member,negative regulator of cell cycle

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS9581826
    GO:0005262calcium channel activity TAS9581826
    GO:0005515protein binding IPI12504025
    GO:0031625ubiquitin protein ligase binding IDA17636018
         
    CUL5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CUL5:
     Decreased nuclei size in G2M  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CUL5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CUL5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CUL5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CUL5 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CUL5:
    hsa-mir-192 (MIRT004846)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CUL5
    8/76 QIAGEN miScript miRNA Assays for microRNAs that regulate CUL5 (see all 76):
    hsa-miR-411* hsa-miR-3607-3p hsa-miR-300 hsa-miR-508-5p hsa-miR-200b hsa-miR-3622a-5p hsa-miR-3667-3p hsa-miR-152
    SwitchGear 3'UTR luciferase reporter plasmidCUL5 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CUL5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CUL5

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CUL5

    Clone
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    OriGene ORF clones in mouse, rat for CUL5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CUL5 (NM_003478)
    Sino Biological Human cDNA Clone for CUL5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CUL5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUL5
    Sirion Biotech Customized lentivirus for stable overexpression of CUL5 
                         Customized lentivirus expression plasmids for stable overexpression of CUL5 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUL5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CUL5 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2HIV Life Cycle
    HIV Infection0.61
    Host Interactions of HIV factors0.60
    3Immune System
    Immune System0.56
    Adaptive Immune System0.56
    4Signaling by FGFR
    Signaling by ERBB20.90
    5CDK-mediated phosphorylation and removal of Cdc6
    Vif-mediated degradation of APOBEC3G0.89

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CUL5
        Common schema of ubiquitination



    5/10        Reactome Pathways for CUL5 (see all 10)
        Adaptive Immune System
    Disease
    Host Interactions of HIV factors
    Signaling by ERBB2
    Vif-mediated degradation of APOBEC3G


    1         Kegg Pathway  (Kegg details for CUL5):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: CUL5_HUMAN, Q93034
    Pathway: Protein modification; protein ubiquitination


    CUL5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CUL5

    5/133 Interacting proteins for CUL5 (Q930341, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 133)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASB2Q96Q272, 3MINT-75029 MINT-77968 MINT-1786035 MINT-7986036 I2D: score=2 
    RBX1P628771, 3EBI-1057139,EBI-398523 I2D: score=5 
    SMAD2Q157962, 3MINT-61623 I2D: score=3 
    ASB1Q9Y5762, 3MINT-77970 I2D: score=2 
    ASB12Q8WXK42, 3MINT-77976 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS8681378
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0006970response to osmotic stress IEA--
    GO:0007050cell cycle arrest TAS8681378
    GO:0008283cell proliferation TAS9037604

    CUL5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CUL5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CUL5

    1 HMDB Compound for CUL5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Vasopressin3-(Phenylalanine)-8-lysine oxytocin (see all 8)11000-17-2--

    2 Novoseek inferred chemical compound relationships for CUL5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acetylene 49.2 3 16636053 (3)
    calcium 0 4 17186378 (1), 15762197 (1)

    Search CenterWatch for drugs/clinical trials and news about CUL5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CUL5 gene: 
    NM_003478.3  

    Unigene Cluster for CUL5:

    Cullin 5
    Hs.440320  [show with all ESTs]
    Unigene Representative Sequence: NM_003478
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393094(uc001pju.3 uc001pjv.3) ENST00000532064 ENST00000526303
    ENST00000531427 ENST00000532782 ENST00000531843
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CUL5
    8/76 QIAGEN miScript miRNA Assays for microRNAs that regulate CUL5 (see all 76):
    hsa-miR-411* hsa-miR-3607-3p hsa-miR-300 hsa-miR-508-5p hsa-miR-200b hsa-miR-3622a-5p hsa-miR-3667-3p hsa-miR-152
    SwitchGear 3'UTR luciferase reporter plasmidCUL5 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUL5
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CUL5

    Additional mRNA sequence: 

    AF017061.1 AF327710.1 AK125294.1 AK292575.1 BC017838.1 BC037203.1 BC063306.1 X81882.1 

    10 DOTS entries:

    DT.441965  DT.442301  DT.120707182  DT.97789810  DT.100748383  DT.120707136  DT.120707137  DT.97823023 
    DT.100680560  DT.40131194 

    24/165 AceView cDNA sequences (see all 165):

    AA732467 AF327710 AA972127 BE674758 AI376842 AA256943 BU633592 AK125294 
    AA403250 AI688961 AI674090 CB053708 BX097158 AI619822 AI478539 AA505090 
    BM786444 AA151127 BX499523 AW268641 AW303561 AI292184 BM718656 BQ576268 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CUL5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGCTTTCC
    CUL5 Expression
    About this image


    See CUL5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CUL5

    SOURCE GeneReport for Unigene cluster: Hs.440320
        SABiosciences Expression via Pathway-Focused PCR Arrays including CUL5: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CUL5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUL5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CUL5 gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cul51 , 5 cullin 51, 5 90.73(n)1
    98.46(a)1
      9 (29.12 cM)5
    757171  NM_027807.31  NP_082083.21 
     536145825 
    chicken
    (Gallus gallus)
    Aves CUL51 cullin 5 87.37(n)
    99.48(a)
      418969  XM_417163.3  XP_417163.3 
    lizard
    (Anolis carolinensis)
    Reptilia CUL56
    cullin 5
    99(a)
    1 ↔ 1
    GL343659.1(194347-239292)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.145002 Xenopus laevis transcribed sequence with strong similarity more 80.17(n)    BJ042671.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi20h122 Danio rerio Vasopressin-activated calcium-mobilizing more 78.76(n)    BC057475.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG14013
    Cul-51
    vasopressin activated calcium
    mobilizing receptor3
    Cullin-51
    67(a)3
    59.58(n)1
    67.19(a)1
      98F63
    434341  NM_143408.21  NP_651665.21 
    worm
    (Caenorhabditis elegans)
    Secernentea cul-51 , 3 Cullin family3
    Protein CUL-51
    49(a)3
    56.2(n)1
    52.98(a)1
      V(10182152-10185480)3
    1794131  NM_073215.31  NP_505616.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC536
    Cullin, structural protein of SCF complexes (which...
    21(a)
    1 → many
    IV(224304-226751)


    ENSEMBL Gene Tree for CUL5 (if available)
    TreeFam Gene Tree for CUL5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CUL5 gene
    CUL12  CUL32  CUL4A2  CUL4B2  CUL22  
    2 SIMAP similar genes for CUL5 using alignment to 5 protein entries:     CUL5_HUMAN (see all proteins):
    CUL1    CUL2

    CUL5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1938 SNPs in CUL5 are shown (see all 1938)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1902555711,2
    --107877412(+) GTGGCA/GCAATC 1 -- us2k10--------
    rs1830288081,2
    --107877763(+) GTAGCA/GTTAAA 1 -- us2k10--------
    rs1871297481,2
    --107877842(+) ATAGCA/GATAGC 1 -- us2k10--------
    rs1919107191,2
    --107877859(+) GCACAG/TGCTGG 1 -- us2k10--------
    rs755827931,2
    F--107877861(+) ACAGGC/TTGGTC 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1143782121,2
    C,F--107877869(+) GTCTCG/CAACCC 1 -- us2k11Minor allele frequency- C:0.08WA 118
    rs1442689361,2
    --107877951(+) GCTGAA/CATGCA 1 -- us2k10--------
    rs797135001,2
    C--107878032(+) ATATAA/GAACAT 1 -- us2k10--------
    rs1179539011,2
    F--107878115(+) TATGTG/ACCTGC 1 -- us2k11Minor allele frequency- A:0.02EA 120
    rs1417327541,2
    --107878269(+) AAGTCA/GGAGTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CUL5 (107879408 - 107978503 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CUL5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2745050CNV Deletion23290073
    nsv507616CNV Insertion20534489
    esv2750980CNV Gain17911159
    nsv521771CNV Gain19592680


    Human Gene Mutation Database (HGMD): CUL5
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CUL5
    DNA2.0 Custom Variant and Variant Library Synthesis for CUL5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601741    OMIM disorders: --

    12 diseases for CUL5:    About MalaCards
    glomuvenous malformation    rabies    ataxia telangiectasia    hiv type 1
    lung adenocarcinoma    ataxia    adenocarcinoma    thyroiditis
    endotheliitis    breast cancer    leukemia    neuronitis


    CUL5 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CUL5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 5 12878869 (1), 19147357 (1)

    Genetic Association Database (GAD): CUL5
    Human Genome Epidemiology (HuGE) Navigator: CUL5 (1 document)

    Export disorders for CUL5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CUL5 gene, integrated from 9 sources (see all 141):
    (articles sorted by number of sources associating them with CUL5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and analysis of expression of human VACM-1, a cullin gene family member located on chromosome 11q22-23. (PubMed id 9037604)1, 2, 3, 9 Byrd P.J....Taylor A.M.R. (1997)
    2. Polymorphisms of CUL5 are associated with CD4+ T cell loss in HIV-1 infected individuals. (PubMed id 17257057)1, 4, 9 An P....Winkler C.A. (2007)
    3. Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery. (PubMed id 12186903)1, 2, 9 Harada J.N.... Berk A.J. (2002)
    4. Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation. (PubMed id 15574592)1, 2, 9 Mehle A.... Gabuzda D. (2004)
    5. ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. (PubMed id 16325183)1, 2 Kohroki J.... Masuho Y. (2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. VHL-box and SOCS-box domains determine binding specificity for Cul2- Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. (PubMed id 15601820)1, 2 Kamura T.... Nakayama K.I. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Muf1, a novel elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase. (PubMed id 11384984)1, 2 Kamura T.... Conaway J.W. (2001)
    10. ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. (PubMed id 10230407)1, 2 Ohta T.... Xiong Y. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8065 HGNC: 2556 AceView: CUL5 Ensembl:ENSG00000166266 euGenes: HUgn8065
    ECgene: CUL5 Kegg: 8065 H-InvDB: CUL5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CUL5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CUL5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CUL5 gene:
    Search GeneIP for patents involving CUL5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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