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Aliases for CUL5 Gene

Aliases for CUL5 Gene

  • Cullin 5 2 3 5
  • Vasopressin-Activated Calcium-Mobilizing Receptor 1 3 4
  • VACM-1 3 4
  • CUL-5 3 4
  • VACM1 3 4
  • Cullin-5 (Vasopressin-Activated Calcium-Mobilizing Receptor-1) 3
  • Vasopressin-Activated Calcium-Mobilizing Receptor-1 3
  • Cullin-5 3

External Ids for CUL5 Gene

Previous GeneCards Identifiers for CUL5 Gene

  • GC11P110074
  • GC11P109236
  • GC11P107913
  • GC11P107417
  • GC11P107384
  • GC11P103804

Summaries for CUL5 Gene

GeneCards Summary for CUL5 Gene

CUL5 (Cullin 5) is a Protein Coding gene. Diseases associated with CUL5 include Alzheimer Disease 16 and Alzheimer Disease 12. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include protein heterodimerization activity and ubiquitin protein ligase binding. An important paralog of this gene is CUL1.

UniProtKB/Swiss-Prot for CUL5 Gene

  • Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.

Gene Wiki entry for CUL5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUL5 Gene

Genomics for CUL5 Gene

Regulatory Elements for CUL5 Gene

Enhancers for CUL5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G107988 1 FANTOM5 12.1 -20.1 -20086 0.4 PKNOX1 ARNT DMAP1 ZBTB40 ZNF335 RELB IKZF2 EGR2 ZNF263 SP3 CUL5 RAB39A
GH11G107927 1 ENCODE 10.3 -80.1 -80099 2.0 PKNOX1 ATF1 SIN3A ZNF2 ZNF121 GLIS2 ZNF143 ZNF207 KLF7 FOS CUL5 DDX10 SLC35F2 ASS1P13 RAB39A
GH11G108008 1.4 ENCODE dbSUPER 0.7 +1.1 1071 3.1 HDGF CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ACAT1 CUL5 GC11P108085
GH11G108020 0.8 ENCODE 0.4 +11.4 11428 0.2 HDAC1 HDGF LEF1 BACH1 ZNF644 HIC1 ZNF766 ZNF316 PATZ1 ZNF600 CUL5 GC11P108085
GH11G108013 0.4 Ensembl 0.7 +4.8 4819 0.2 ZNF10 HMBOX1 ACAT1 CUL5 GC11P108085
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CUL5 on UCSC Golden Path with GeneCards custom track

Promoters for CUL5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000044496 919 2400 HDGF MLX CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for CUL5 Gene

Chromosome:
11
Start:
108,008,682 bp from pter
End:
108,107,776 bp from pter
Size:
99,095 bases
Orientation:
Plus strand

Genomic View for CUL5 Gene

Genes around CUL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CUL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CUL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUL5 Gene

Proteins for CUL5 Gene

  • Protein details for CUL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93034-CUL5_HUMAN
    Recommended name:
    Cullin-5
    Protein Accession:
    Q93034
    Secondary Accessions:
    • A8K960
    • O14766
    • Q9BZC6

    Protein attributes for CUL5 Gene

    Size:
    780 amino acids
    Molecular mass:
    90955 Da
    Quaternary structure:
    • Component of multiple ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes formed of CUL5, Elongin BC (ELOB and ELOC), RBX2 and a variable SOCS box domain-containing protein as substrate-specific recognition component. Component of the probable ECS(LRRC41) complex with the substrate recognition component LRRC41. Component of the probable ECS(SOCS1) complex with the substrate recognition component SOCS1. Component of the probable ECS(WSB1) complex with the substrate recognition subunit WSB1. Component of the probable ECS(SOCS3) complex with the substrate recognition component SOCS3. Component of the probable ECS(SPSB1) complex with the substrate recognition component SPSB1. Component of the probable ECS(SPSB2) complex with the substrate recognition component SPSB2. Component of the probable ECS(SPSB4) complex with the substrate recognition component SPSB4. Component of the probable ECS(RAB40C) complex with the substrate recognition subunit RAB40C. May also form complexes containing CUL5, elongin BC complex (ELOB and ELOC), RBX1 and ELOA. May also form complexes containing CUL5, Elongin BC (ELOB and ELOC), RBX1 and VHL. Interacts with RNF7/RBX2, LRRC41, SOCS3, SPSB1, SPSB2, SPSB4 and RAB40C. Interacts with ASB1, ASB2, ASB6, ASB7 and ASB12. Interacts (when neddylated) with ARIH2; leading to activate the E3 ligase activity of ARIH1 (PubMed:24076655).
    • (Microbial infection) The substrate recognition component can also be a viral protein such as HIV Vif, or human adenovirus 5 E1B large T-antigen and E4-orf6.

    Three dimensional structures from OCA and Proteopedia for CUL5 Gene

neXtProt entry for CUL5 Gene

Post-translational modifications for CUL5 Gene

  • Neddylated; which enhances the ubiquitination activity of SCF and prevents binding of the inhibitor CAND1. Deneddylated via its interaction with the COP9 signalosome (CSN).
  • Ubiquitination at Lys384, isoforms=529, and isoforms=724
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CUL5 Gene

Domains & Families for CUL5 Gene

Gene Families for CUL5 Gene

Suggested Antigen Peptide Sequences for CUL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q93034

UniProtKB/Swiss-Prot:

CUL5_HUMAN :
  • Belongs to the cullin family.
Family:
  • Belongs to the cullin family.
genes like me logo Genes that share domains with CUL5: view

Function for CUL5 Gene

Molecular function for CUL5 Gene

GENATLAS Biochemistry:
cullin 5,widely expressed,C elegans,cullin Cdc53 (CUL) family member,negative regulator of cell cycle
UniProtKB/Swiss-Prot Function:
Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.

Gene Ontology (GO) - Molecular Function for CUL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0004872 receptor activity TAS 9581826
GO:0005262 calcium channel activity TAS 9581826
GO:0005515 protein binding IPI 12504025
GO:0031625 ubiquitin protein ligase binding IEA,IDA 17636018
genes like me logo Genes that share ontologies with CUL5: view
genes like me logo Genes that share phenotypes with CUL5: view

Animal Models for CUL5 Gene

MGI Knock Outs for CUL5:
  • Cul5 tm1.1(KOMP)Vlcg

Animal Model Products

  • Taconic Biosciences Mouse Models for CUL5

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CUL5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CUL5 Gene

Localization for CUL5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CUL5 gene
Compartment Confidence
cytosol 5
nucleus 3
golgi apparatus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CUL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0031461 cullin-RING ubiquitin ligase complex IEA --
GO:0031466 Cul5-RING ubiquitin ligase complex IDA 17636018
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with CUL5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CUL5 Gene

Pathways & Interactions for CUL5 Gene

genes like me logo Genes that share pathways with CUL5: view

UniProtKB/Swiss-Prot Q93034-CUL5_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for CUL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS 8681378
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0006974 cellular response to DNA damage stimulus IBA --
GO:0007050 cell cycle arrest TAS 8681378
GO:0008283 cell proliferation TAS 9037604
genes like me logo Genes that share ontologies with CUL5: view

No data available for SIGNOR curated interactions for CUL5 Gene

Drugs & Compounds for CUL5 Gene

(2) Drugs for CUL5 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vasopressin Approved Pharma Full agonist, Agonist 0

(1) Additional Compounds for CUL5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CUL5: view

Transcripts for CUL5 Gene

Unigene Clusters for CUL5 Gene

Cullin 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CUL5

Alternative Splicing Database (ASD) splice patterns (SP) for CUL5 Gene

No ASD Table

Relevant External Links for CUL5 Gene

GeneLoc Exon Structure for
CUL5
ECgene alternative splicing isoforms for
CUL5

Expression for CUL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CUL5 Gene

mRNA differential expression in normal tissues according to GTEx for CUL5 Gene

This gene is overexpressed in Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for CUL5 Gene

This gene is overexpressed in Lymph node (8.3) and Uterus (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CUL5 Gene



Protein tissue co-expression partners for CUL5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CUL5 Gene:

CUL5

SOURCE GeneReport for Unigene cluster for CUL5 Gene:

Hs.440320

Evidence on tissue expression from TISSUES for CUL5 Gene

  • Nervous system(3)
  • Kidney(2.3)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with CUL5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CUL5 Gene

Orthologs for CUL5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CUL5 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia CUL5 35
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CUL5 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CUL5 34 35
  • 99.83 (n)
cow
(Bos Taurus)
Mammalia CUL5 34 35
  • 96.03 (n)
dog
(Canis familiaris)
Mammalia CUL5 34 35
  • 95.83 (n)
rat
(Rattus norvegicus)
Mammalia Cul5 34
  • 91.28 (n)
mouse
(Mus musculus)
Mammalia Cul5 34 16 35
  • 90.73 (n)
chicken
(Gallus gallus)
Aves CUL5 34 35
  • 87.26 (n)
lizard
(Anolis carolinensis)
Reptilia CUL5 35
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cul5 34
  • 81.84 (n)
Str.17488 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.14500 34
zebrafish
(Danio rerio)
Actinopterygii cul5a 35
  • 97 (a)
OneToMany
cul5b 34 35
  • 78.89 (n)
wufi20h12 34
fruit fly
(Drosophila melanogaster)
Insecta CG1401 36
  • 67 (a)
Cul-5 34 35
  • 59.5 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002404 34
  • 60.39 (n)
worm
(Caenorhabditis elegans)
Secernentea cul-5 36 34 35
  • 56.22 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3614 35
  • 65 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7070 34
Species where no ortholog for CUL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CUL5 Gene

ENSEMBL:
Gene Tree for CUL5 (if available)
TreeFam:
Gene Tree for CUL5 (if available)

Paralogs for CUL5 Gene

Paralogs for CUL5 Gene

(2) SIMAP similar genes for CUL5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CUL5: view

Variants for CUL5 Gene

Sequence variations from dbSNP and Humsavar for CUL5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000011348 -- 108,062,237(+) ACATC(C/G)TTGTG intron-variant
rs1000046461 -- 108,035,789(+) TTTAT(G/T)GAGTA intron-variant
rs1000047516 -- 108,075,142(+) GATGA(A/T)GGAGG intron-variant
rs1000076109 -- 108,019,734(+) TATCC(-/TAATAA)TAATA intron-variant
rs1000083029 -- 108,050,427(+) GCAGT(A/G)GCGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CUL5 Gene

Variant ID Type Subtype PubMed ID
dgv1274n100 CNV gain 25217958
dgv1276n100 CNV gain 25217958
dgv1278n100 CNV gain 25217958
esv2745050 CNV deletion 23290073
esv2750980 CNV gain 17911159
nsv1040345 CNV gain 25217958
nsv1127231 CNV deletion 24896259
nsv472392 CNV novel sequence insertion 20440878
nsv478868 CNV novel sequence insertion 20440878
nsv507616 OTHER sequence alteration 20534489
nsv521771 CNV gain 19592680

Variation tolerance for CUL5 Gene

Residual Variation Intolerance Score: 9.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CUL5 Gene

Human Gene Mutation Database (HGMD)
CUL5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CUL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CUL5 Gene

Disorders for CUL5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CUL5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
alzheimer disease 16
  • alzheimer's disease 16
alzheimer disease 12
  • alzheimer's disease 12
alzheimer's disease 11
  • ad11
- elite association - COSMIC cancer census association via MalaCards
Search CUL5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CUL5

Genetic Association Database (GAD)
CUL5
Human Genome Epidemiology (HuGE) Navigator
CUL5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CUL5
genes like me logo Genes that share disorders with CUL5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CUL5 Gene

Publications for CUL5 Gene

  1. Identification and analysis of expression of human VACM-1, a cullin gene family member located on chromosome 11q22-23. (PMID: 9037604) Byrd P.J. … Taylor A.M.R. (Genome Res. 1997) 2 3 4 22 64
  2. Polymorphisms of CUL5 are associated with CD4+ T cell loss in HIV-1 infected individuals. (PMID: 17257057) An P. … Winkler C.A. (PLoS Genet. 2007) 3 22 46 64
  3. Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation. (PMID: 15574592) Mehle A. … Gabuzda D. (Genes Dev. 2004) 3 4 22 64
  4. Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery. (PMID: 12186903) Harada J.N. … Berk A.J. (J. Virol. 2002) 3 4 22 64
  5. TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes. (PMID: 24076655) Kelsall I.R. … Alpi A.F. (EMBO J. 2013) 3 4 64

Products for CUL5 Gene

  • Addgene plasmids for CUL5

Sources for CUL5 Gene

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