Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CUL4B Gene

Aliases for CUL4B Gene

  • Cullin 4B 2 3 5
  • CUL-4B 3 4
  • KIAA0695 4
  • MRXHF2 3
  • MRXS15 3
  • MRXSC 3
  • SFM2 3

External Ids for CUL4B Gene

Previous GeneCards Identifiers for CUL4B Gene

  • GC0XM114476
  • GC0XM116644
  • GC0XM117633
  • GC0XM118412
  • GC0XM119440
  • GC0XM119543
  • GC0XM119658
  • GC0XM109109

Summaries for CUL4B Gene

Entrez Gene Summary for CUL4B Gene

  • This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CUL4B Gene

CUL4B (Cullin 4B) is a Protein Coding gene. Diseases associated with CUL4B include mental retardation, x-linked, syndromic 15 and x-linked intellectual disability, cabezas type. Among its related pathways are Nucleotide excision repair and Antigen processing- Ubiquitination and Proteasome degradation. GO annotations related to this gene include ubiquitin protein ligase binding and damaged DNA binding. An important paralog of this gene is CUL1.

UniProtKB/Swiss-Prot for CUL4B Gene

  • Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8.

Gene Wiki entry for CUL4B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUL4B Gene

Genomics for CUL4B Gene

Regulatory Elements for CUL4B Gene

Enhancers for CUL4B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CUL4B on UCSC Golden Path with GeneCards custom track

Genomic Location for CUL4B Gene

Chromosome:
X
Start:
120,524,589 bp from pter
End:
120,575,829 bp from pter
Size:
51,241 bases
Orientation:
Minus strand

Genomic View for CUL4B Gene

Genes around CUL4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CUL4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CUL4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUL4B Gene

Proteins for CUL4B Gene

  • Protein details for CUL4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13620-CUL4B_HUMAN
    Recommended name:
    Cullin-4B
    Protein Accession:
    Q13620
    Secondary Accessions:
    • B1APK5
    • B3KVX4
    • B7Z5K8
    • Q6PIE4
    • Q6UP07
    • Q7Z673
    • Q9BY37
    • Q9UEB7
    • Q9UED7

    Protein attributes for CUL4B Gene

    Size:
    913 amino acids
    Molecular mass:
    103982 Da
    Quaternary structure:
    • Component of multiple DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes that seem to be formed of DDB1, CUL4A or CUL4B, RBX1 and a variable substrate recognition component which seems to belong to a protein family described as DCAF (Ddb1- and Cul4-associated factor) or CDW (CUL4-DDB1-associated WD40-repeat) proteins. Component of the DCX(DTL) complex with the putative substrate recognition component DTL. Component of the DCX(DDB2) complex with the putative substrate recognition component DDB2. Part of a complex with RBX1 and TIP120A/CAND1. Interacts with RBX1 GRWD1, MLST8, SMU1, TLE2, TLE3, VPRBP, DDA1, DCAF6, DCAF17, DDB2, DCAF8, TIP120A/CAND1 and TMEM113. Interacts with cyclin E and with importins alpha-1 (KPNA2), alpha-3 (KPNA4), alpha-5 (KPNA1) and beta-1 (KPNB1). May interact with WDR26, WDR51B, SNRNP40, WDR61, WDR76 and WDR5.
    SequenceCaution:
    • Sequence=AAB67315.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAK16812.1; Type=Frameshift; Positions=115; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CUL4B Gene

    Alternative splice isoforms for CUL4B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CUL4B Gene

Proteomics data for CUL4B Gene at MOPED

Post-translational modifications for CUL4B Gene

  • Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.
  • Ubiquitination at Lys 240, Lys 385, Lys 495, Lys 582, Lys 691, and Lys 844
  • Modification sites at PhosphoSitePlus

Other Protein References for CUL4B Gene

Antibody Products

No data available for DME Specific Peptides for CUL4B Gene

Domains & Families for CUL4B Gene

Gene Families for CUL4B Gene

Suggested Antigen Peptide Sequences for CUL4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13620

UniProtKB/Swiss-Prot:

CUL4B_HUMAN :
  • Belongs to the cullin family.
Family:
  • Belongs to the cullin family.
genes like me logo Genes that share domains with CUL4B: view

Function for CUL4B Gene

Molecular function for CUL4B Gene

UniProtKB/Swiss-Prot Function:
Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8.
genes like me logo Genes that share phenotypes with CUL4B: view

Human Phenotype Ontology for CUL4B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CUL4B Gene

MGI Knock Outs for CUL4B:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for CUL4B Gene

Localization for CUL4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CUL4B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CUL4B Gene COMPARTMENTS Subcellular localization image for CUL4B gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
plasma membrane 2

Gene Ontology (GO) - Cellular Components for CUL4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CUL4B: view

Pathways & Interactions for CUL4B Gene

genes like me logo Genes that share pathways with CUL4B: view

Pathways by source for CUL4B Gene

UniProtKB/Swiss-Prot Q13620-CUL4B_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for CUL4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000715 nucleotide-excision repair, DNA damage recognition TAS --
GO:0000717 nucleotide-excision repair, DNA duplex unwinding TAS --
GO:0006281 DNA repair TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006289 nucleotide-excision repair TAS --
genes like me logo Genes that share ontologies with CUL4B: view

No data available for SIGNOR curated interactions for CUL4B Gene

Drugs & Compounds for CUL4B Gene

No Compound Related Data Available

Transcripts for CUL4B Gene

Unigene Clusters for CUL4B Gene

Cullin 4B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CUL4B Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: - - - -
SP2: - - - -
SP3:
SP4:
SP5: - -
SP6: -
SP7: - -
SP8:
SP9:

ExUns: 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for CUL4B Gene

GeneLoc Exon Structure for
CUL4B
ECgene alternative splicing isoforms for
CUL4B

Expression for CUL4B Gene

mRNA expression in normal human tissues for CUL4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CUL4B Gene

This gene is overexpressed in Bone (38.5) and Lymph node (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CUL4B Gene



SOURCE GeneReport for Unigene cluster for CUL4B Gene Hs.102914

genes like me logo Genes that share expression patterns with CUL4B: view

Protein tissue co-expression partners for CUL4B Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CUL4B Gene

Orthologs for CUL4B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CUL4B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CUL4B 35
  • 94.31 (n)
  • 98.65 (a)
CUL4B 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CUL4B 35
  • 96.52 (n)
  • 99.55 (a)
CUL4B 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cul4b 35
  • 92.04 (n)
  • 97.71 (a)
Cul4b 16
Cul4b 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cul4b 35
  • 92.28 (n)
  • 98.29 (a)
oppossum
(Monodelphis domestica)
Mammalia CUL4B 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CUL4B 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CUL4B 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves CUL4B 35
  • 82.88 (n)
  • 92.05 (a)
CUL4B 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CUL4B 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cul4b 35
  • 81.39 (n)
  • 90.67 (a)
Str.6401 35
zebrafish
(Danio rerio)
Actinopterygii cul4b 35
  • 75.62 (n)
  • 86.69 (a)
cul4b 36
  • 84 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta cul-4 37
  • 69 (a)
Cul-4 35
  • 60.65 (n)
  • 64.97 (a)
Cul-4 36
  • 62 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007727 35
  • 62.77 (n)
  • 66.39 (a)
worm
(Caenorhabditis elegans)
Secernentea cul-4 37
  • 33 (a)
cul-4 36
  • 31 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CUL4 35
  • 59.12 (n)
  • 57.24 (a)
soybean
(Glycine max)
eudicotyledons Gma.6896 35
barley
(Hordeum vulgare)
Liliopsida Hv.5410 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9784 36
  • 54 (a)
OneToMany
Species with no ortholog for CUL4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CUL4B Gene

ENSEMBL:
Gene Tree for CUL4B (if available)
TreeFam:
Gene Tree for CUL4B (if available)

Paralogs for CUL4B Gene

Paralogs for CUL4B Gene

(4) SIMAP similar genes for CUL4B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CUL4B: view

Variants for CUL4B Gene

Sequence variations from dbSNP and Humsavar for CUL4B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs61759504 - 120,560,385(+) CCCCC(A/G)GGCAG upstream-variant-2KB, reference, missense
VAR_032273 -
VAR_032274 Mental retardation, X-linked, syndromic, 15 (MRXS15)
VAR_032275 Mental retardation, X-linked, syndromic, 15 (MRXS15)
rs747671064 -- 120,562,767(+) GAAAG(C/T)GCAGT intron-variant, upstream-variant-2KB

Variation tolerance for CUL4B Gene

Residual Variation Intolerance Score: 7.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CUL4B Gene

HapMap Linkage Disequilibrium report
CUL4B
Human Gene Mutation Database (HGMD)
CUL4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CUL4B Gene

Disorders for CUL4B Gene

MalaCards: The human disease database

(5) MalaCards diseases for CUL4B Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CUL4B in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CUL4B_HUMAN
  • Mental retardation, X-linked, syndromic, 15 (MRXS15) [MIM:300354]: A syndromic form of X-linked mental retardation characterized by severe intellectual deficit associated with short stature, craniofacial dysmorphism, small testes, muscle wasting in lower legs, kyphosis, joint hyperextensibility, pes cavus, small feet, and abnormalities of the toes. Additional neurologic manifestations include speech delay and impairment, tremor, seizures, gait ataxia, hyperactivity and decreased attention span. {ECO:0000269 PubMed:17236139, ECO:0000269 PubMed:17273978, ECO:0000269 PubMed:19377476, ECO:0000269 PubMed:20002452}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CUL4B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CUL4B
genes like me logo Genes that share disorders with CUL4B: view

No data available for Genatlas for CUL4B Gene

Publications for CUL4B Gene

  1. cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. (PMID: 8681378) Kipreos E.T. … Hedgecock E.M. (Cell 1996) 2 3 4 67
  2. Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaks. (PMID: 20064923) Kerzendorfer C. … O'Driscoll M. (Hum. Mol. Genet. 2010) 3 23
  3. The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A. (PMID: 18593899) Guerrero-Santoro J. … Rapic-Otrin V. (Cancer Res. 2008) 3 23
  4. A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. (PMID: 19056892) Miranda-Carboni G.A. … Lane T.F. (Genes Dev. 2008) 3 23
  5. CRL4B promotes tumorigenesis by coordinating with SUV39H1/HP1/DNMT3A in DNA methylation-based epigenetic silencing. (PMID: 24292684) Yang Y. … Wang Y. (Oncogene 2015) 3

Products for CUL4B Gene

Sources for CUL4B Gene

Content