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CUL4B Gene

protein-coding   GIFtS: 65
GCID: GC0XM119658

Cullin 4B

  See CUL4B-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cullin 4B1 2     MRXSC2 5
CUL-4B2 3     SFM22 5
MRXHF22 5     cullin-4B2
MRXS152 5     KIAA06953

External Ids:    HGNC: 25551   Entrez Gene: 84502   Ensembl: ENSG000001582907   OMIM: 3003045   UniProtKB: Q136203   

Export aliases for CUL4B gene to outside databases

Previous GC identifers: GC0XM114476 GC0XM116644 GC0XM117633 GC0XM118412 GC0XM119440 GC0XM119543 GC0XM109109


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CUL4B Gene:
This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin
ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts
with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication
including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CUL4B Gene:
CUL4B (cullin 4B) is a protein-coding gene. Diseases associated with CUL4B include mental retardation, x-linked, syndromic 15, and mental retardation, x-linked, with short stature, small testes, muscle wasting, and tremor. GO annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is CUL1.

UniProtKB/Swiss-Prot: CUL4B_HUMAN, Q13620
Function: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the
ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3
ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the
complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the
ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in
polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage.
Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for
ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian
target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B
regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction
between CUL4B and MLST8

Gene Wiki entry for CUL4B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011786.17  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CUL4B gene promoter:
         Nkx3-1   USF1   Sp1   p53   p300   YY1   N-Myc   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CUL4B promoter sequence
   Search Chromatin IP Primers for CUL4B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CUL4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq23   Ensembl cytogenetic band:  Xq24   HGNC cytogenetic band: Xq23

CUL4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CUL4B gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM119658:  view genomic region     (about GC identifiers)

Start:
119,658,444 bp from pter      End:
119,709,684 bp from pter
Size:
51,241 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CUL4B_HUMAN, Q13620 (See protein sequence)
Recommended Name: Cullin-4B  
Size: 913 amino acids; 103982 Da
Subunit: Component of multiple DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes that seem to be formed
of DDB1, CUL4A or CUL4B, RBX1 and a variable substrate recognition component which seems to belong to a protein
family described as DCAF (Ddb1- and Cul4-associated factor) or CDW (CUL4-DDB1-associated WD40-repeat) proteins.
Component of the DCX(DTL) complex with the putative substrate recognition component DTL. Component of the
DCX(DDB2) complex with the putative substrate recognition component DDB2. Part of a complex with RBX1 and
TIP120A/CAND1. Interacts with RBX1 GRWD1, MLST8, SMU1, TLE2, TLE3, VPRBP, DDA1, DCAF6, DCAF17, DDB2, DCAF8,
TIP120A/CAND1 and TMEM113. Interacts with cyclin E and with importins alpha-1 (KPNA2), alpha-3 (KPNA4), alpha-5
(KPNA1) and beta-1 (KPNB1). May interact with WDR26, WDR51B, SNRNP40, WDR61, WDR76 and WDR5
Sequence caution: Sequence=AAB67315.1; Type=Erroneous gene model prediction; Sequence=AAK16812.1; Type=Frameshift;
Positions=115;
4 PDB 3D structures from and Proteopedia for CUL4B:
2DO7 (3D)        4A0C (3D)        4A0L (3D)        4A64 (3D)    
Secondary accessions: B1APK5 B3KVX4 B7Z5K8 Q6PIE4 Q6UP07 Q7Z673 Q9BY37 Q9UEB7 Q9UED7
Alternative splicing: 3 isoforms:  Q13620-2   Q13620-1   Q13620-3   (Contains a N-acetylmethionine at position 1. Contains a phosphoserine at position 8. Contains a phosphoserine at position 10)

Explore the universe of human proteins at neXtProt for CUL4B: NX_Q13620

Explore proteomics data for CUL4B at MOPED

Post-translational modifications: 

  • Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex1
  • Ubiquitination2 at Lys240, Lys385, Lys495, Lys582, Lys632, Lys691, Lys844
  • Modification sites at PhosphoSitePlus

  • See CUL4B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001073341.1  NP_003579.3  

    ENSEMBL proteins: 
     ENSP00000360373   ENSP00000338919   ENSP00000384109   ENSP00000360374  

    CUL4B Human Recombinant Protein Products:

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    Novus Biologicals CUL4B Protein
    Novus Biologicals CUL4B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CUL4B

     
    Search eBioscience for Proteins for CUL4B 

     
    antibodies-online proteins for CUL4B (2 products) 

     
    antibodies-online peptides for CUL4B

    CUL4B Antibody Products:

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    ThermoFisher Antibody for CUL4B
    LSBio Antibodies in human, mouse, rat for CUL4B
    antibodies-online antibodies for CUL4B (47 products) 

    CUL4B Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for CUL4B
    Cloud-Clone Corp. CLIAs for CUL4B
    Search eBioscience for ELISAs for CUL4B 
    antibodies-online kits for CUL4B (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR016159 Cullin_repeat-like_dom
     IPR019559 Cullin_neddylation_domain
     IPR016157 Cullin_CS
     IPR001373 Cullin_N
     IPR011991 WHTH_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q13620

    ProtoNet protein and cluster: Q13620

    1 Blocks protein domain: IPB001373 Cullin

    UniProtKB/Swiss-Prot: CUL4B_HUMAN, Q13620
    Similarity: Belongs to the cullin family


    Find genes that share domains with CUL4B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CUL4B_HUMAN, Q13620
    Function: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the
    ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3
    ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the
    complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the
    ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in
    polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage.
    Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for
    ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian
    target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B
    regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction
    between CUL4B and MLST8

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12609982
    GO:0031625ubiquitin protein ligase binding IEA--
         
    Find genes that share ontologies with CUL4B           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CUL4B:
     Increased cell death in HCT116  Increased cell death in breast 

         9 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Cul4b):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size/body 
     integument  mortality/aging  nervous system  normal 

    Find genes that share phenotypes with CUL4B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cul4btm1.1Yxg for CUL4B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CUL4B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CUL4B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CUL4B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CUL4B

    miRNA
    Products:
        
    miRTarBase miRNAs that target CUL4B:
    hsa-mir-155-5p (MIRT001556), hsa-mir-1 (MIRT023489), hsa-mir-27b-3p (MIRT046192), hsa-mir-877-3p (MIRT037054)

    Block miRNA regulation of human, mouse, rat CUL4B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CUL4B (see all 34):
    hsa-miR-142-5p hsa-miR-579 hsa-miR-3664-5p hsa-miR-4272 hsa-miR-200a hsa-let-7a-2* hsa-miR-141 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidCUL4B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CUL4B
    Predesigned siRNA for gene silencing in human, mouse, rat CUL4B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CUL4B

    Clone
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    OriGene clones in human, mouse for CUL4B (see all 12)
    OriGene ORF clones in mouse, rat for CUL4B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CUL4B (NM_003588)
    Sino Biological Human cDNA Clone for CUL4B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CUL4B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUL4B
    Addgene plasmids for CUL4B 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUL4B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CUL4B_HUMAN, Q13620: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane4
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--
    GO:0031461cullin-RING ubiquitin ligase complex ----

    Find genes that share ontologies with CUL4B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CUL4B About    
    See pathways by source

    SuperPathContained pathways About
    1Global Genomic NER (GG-NER)
    Nucleotide excision repair0.69
    2Class I MHC mediated antigen processing and presentation
    Ubiquitin mediated proteolysis0.35


    Find genes that share SuperPaths with CUL4B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2 Kegg Pathways  (Kegg details for CUL4B):
        Nucleotide excision repair
    Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: CUL4B_HUMAN, Q13620
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CUL4B: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CUL4B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CUL4B (Q136201, 2, 3 ENSP000003841094) via UniProtKB, MINT, STRING, and/or I2D (see all 196)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4LP628053, ENSP000003482584I2D: score=1 STRING: ENSP00000348258
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0007049cell cycle NAS8681378
    GO:0016567protein ubiquitination IEA--
    GO:0045732positive regulation of protein catabolic process IEA--

    Find genes that share ontologies with CUL4B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CUL4B



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CUL4B gene (2 alternative transcripts): 
    NM_001079872.1  NM_003588.3  

    Unigene Cluster for CUL4B:

    Cullin 4B
    Hs.102914  [show with all ESTs]
    Unigene Representative Sequence: NM_003588
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371322(uc010nqq.3 uc004esv.3 uc004esw.3) ENST00000336592
    ENST00000404115 ENST00000497616 ENST00000371323 ENST00000467641 ENST00000486604

    miRNA
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    Block miRNA regulation of human, mouse, rat CUL4B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CUL4B (see all 34):
    hsa-miR-142-5p hsa-miR-579 hsa-miR-3664-5p hsa-miR-4272 hsa-miR-200a hsa-let-7a-2* hsa-miR-141 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidCUL4B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CUL4B
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    GenScript: all cDNA clones in your preferred vector (see all 2): CUL4B (NM_003588)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CUL4B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUL4B
    Addgene plasmids for CUL4B 
    Primer
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    OriGene qPCR primer pairs and template standards for CUL4B
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CUL4B
      QuantiTect SYBR Green Assays in human, mouse, rat CUL4B
      QuantiFast Probe-based Assays in human, mouse, rat CUL4B

    Additional mRNA sequence: 

    AB014595.2 AF212995.1 AK123688.1 AK299081.1 AK315037.1 AY365125.1 BC036216.1 BX537787.1 
    BX647096.1 CR936722.1 U58091.1 

    16 DOTS entries:

    DT.40305957  DT.100831949  DT.443666  DT.121311139  DT.100717818  DT.91752442  DT.121311125  DT.100653336 
    DT.100653337  DT.75175626  DT.40125199  DT.121310980  DT.121311038  DT.86857972  DT.91753185  DT.100655219 

    Selected AceView cDNA sequences (see all 308):

    AW072843 AI927107 AA045927 AA313465 BX342962 N33201 AV659562 AA393189 
    BQ422243 AA600959 BG057936 BM770833 BQ432443 AV659492 AA721377 AV659445 
    BF094640 AW157684 AI963347 AA370874 BP366384 AA989057 AW474599 BE537576 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CUL4B (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                                                              -           -     -     -                                                                     
    SP2:                                                              -           -     -     -                                                                     
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                              -           -                                                                                 

    ExUns: 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b
    SP1:  -                                                   
    SP2:  -                                                   
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for CUL4B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CUL4B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGTTTTCC
    CUL4B Expression
    About this image


    CUL4B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    CUL4B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CUL4B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.102914
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CUL4B: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CUL4B gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cul4b1 , 5 cullin 4B1, 5 92.04(n)1
    97.71(a)1
      X (22.81 cM)5
    725841  NM_001110142.11  NP_001103612.11 
     385332745 
    chicken
    (Gallus gallus)
    Aves CUL4B1 cullin 4B 82.88(n)
    92.05(a)
      422364  XM_420335.4  XP_420335.2 
    lizard
    (Anolis carolinensis)
    Reptilia CUL4B6
    cullin 4B
    88(a)
    1 ↔ 1
    GL343839.1(8233-28752)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU915683.12   -- 81.2(n)    BU915683.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cul4b1 cullin 4B 75.62(n)
    86.69(a)
      560313  NM_001122844.1  NP_001116316.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cul-43
    Cul-41
    ubiquitin-protein ligase3
    Cullin-41
    69(a)3
    60.65(n)1
    64.97(a)1
      44B13
    357801  NM_001169613.11  NP_001163084.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cul-43 Expression: all stages 33(a)   II(7302044-7305464)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CUL41 CUL4 59.12(n)
    57.24(a)
      834663  NM_123990.2  NP_568658.1 
    rice
    (Oryza sativa)
    Liliopsida AK059186.12   -- 74.83(n)    AK059186.1 


    ENSEMBL Gene Tree for CUL4B (if available)
    TreeFam Gene Tree for CUL4B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CUL4B gene
    CUL12  CUL32  CUL4A2  CUL22  CUL52  
    4 SIMAP similar genes for CUL4B using alignment to 3 protein entries:     CUL4B_HUMAN (see all proteins):
    CUL4A    CUL3    CUL2    CUL1

    Find genes that share paralogs with CUL4B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CUL4B (see all 680)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0322754
    Mental retardation, X-linked, syndromic, 15 (MRXS15)4--see VAR_0322752 V A mis40--------
    VAR_0322744
    Mental retardation, X-linked, syndromic, 15 (MRXS15)4--see VAR_0322742 R C mis40--------
    rs1214346161,2
    Cpathogenic1119671920(-) AACAAC/TGATTT 4 R * stg10--------
    rs1381400791,2
    C--119651849(+) ACACAA/GCAAAA 2 -- ds50010--------
    rs1495743221,2
    C--119651868(+) AGTATA/GGCTAG 2 -- ds50010--------
    rs1907473161,2
    --119651949(+) AGAGTA/TTCTGG 2 -- ds50010--------
    rs115494111,2
    C,H--119652454(+) TGAAAG/TTCACA 2 -- ut311Minor allele frequency- T:0.01NS 170
    rs142791,2
    C--119652551(-) CTGTTT/CCAGCT 2 -- ut31 ese32Minor allele frequency- C:0.00MN NA 186
    rs1819784161,2
    --119652646(+) CAGGAA/CCAACT 2 -- ut310--------
    rs558482121,2
    C--119652715(+) ACCATC/TAGGGA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for CUL4B (119658444 - 119709684 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CUL4B: --
    Human Gene Mutation Database (HGMD): CUL4B
    Locus Specific Mutation Databases (LSDB): CUL4B

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CUL4B
    DNA2.0 Custom Variant and Variant Library Synthesis for CUL4B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300304   
    OMIM disorders: 300354  
    UniProtKB/Swiss-Prot: CUL4B_HUMAN, Q13620
  • Mental retardation, X-linked, syndromic, 15 (MRXS15) [MIM:300354]: A syndromic form of X-linked mental
    retardation characterized by severe intellectual deficit associated with short stature, craniofacial dysmorphism,
    small testes, muscle wasting in lower legs, kyphosis, joint hyperextensibility, pes cavus, small feet, and
    abnormalities of the toes. Additional neurologic manifestations include speech delay and impairment, tremor,
    seizures, gait ataxia, hyperactivity and decreased attention span. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 3 diseases for CUL4B:    
    About MalaCards
    mental retardation, x-linked, syndromic 15    mental retardation, x-linked, with short stature, small testes, muscle wasting, and tremor    conjunctivochalasis

    3 diseases from the University of Copenhagen DISEASES database for CUL4B:
    Intellectual disability     Scheuermann's disease     Conjunctivochalasis

    Find genes that share disorders with CUL4B           About GenesLikeMe


    Export disorders for CUL4B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CUL4B gene, integrated from 10 sources (see all 94):
    (articles sorted by number of sources associating them with CUL4B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. (PubMed id 8681378)1, 2, 3 Kipreos E.T.... Hedgecock E.M. (Cell 1996)
    2. The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A. (PubMed id 18593899)1, 2, 9 Guerrero-Santoro J.... Rapic-Otrin V. (Cancer Res. 2008)
    3. A novel nonsense mutation in CUL4B gene in three brothers with X- linked mental retardation syndrome. (PubMed id 20002452)1, 2 Badura-Stronka M.... Latos-Bielenska A. (Clin. Genet. 2010)
    4. Characterization of nuclear localization signal in the N terminus of CUL4B and its essential role in cyclin E degradation and cell cycle progression. (PubMed id 19801544)1, 2 Zou Y.... Gong Y. (J. Biol. Chem. 2009)
    5. mTORC1 signaling requires proteasomal function and the involvement of CUL4-DDB1 ubiquitin E3 ligase. (PubMed id 18235224)1, 2 Ghosh P.... Sun H. (Cell Cycle 2008)
    6. Mutation in CUL4B, which encodes a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardation. (PubMed id 17273978)1, 2 Zou Y.... Gong Y. (Am. J. Hum. Genet. 2007)
    7. Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor. (PubMed id 17236139)1, 2 Tarpey P.S.... Partington M. (Am. J. Hum. Genet. 2007)
    8. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PubMed id 16949367)1, 2 Jin J.... Walter J.C. (Mol. Cell 2006)
    9. Involvement of CUL4 ubiquitin E3 ligases in regulating CDK inhibitors Dacapo/p27Kip1 and cyclin E degradation. (PubMed id 16322693)1, 2 Higa L.A....Zhang H. (Cell Cycle 2006)
    10. Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. (PubMed id 16678110)1, 2 Wang H.... Zhang Y. (Mol. Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8450 HGNC: 2555 AceView: CUL4B Ensembl:ENSG00000158290 euGenes: HUgn8450
    ECgene: CUL4B Kegg: 8450 H-InvDB: CUL4B

    (According to HUGE)
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    HUGE: KIAA0695

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CUL4B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CUL4B Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=CUL4B[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CUL4B gene:
    Search GeneIP for patents involving CUL4B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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