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Aliases for CUL4B Gene

Aliases for CUL4B Gene

  • Cullin 4B 2 3
  • MRXHF2 3 6
  • MRXS15 3 6
  • CUL-4B 3 4
  • MRXSC 3 6
  • SFM2 3 6
  • Cullin-4B 3
  • KIAA0695 4

External Ids for CUL4B Gene

Previous GeneCards Identifiers for CUL4B Gene

  • GC0XM114476
  • GC0XM116644
  • GC0XM117633
  • GC0XM118412
  • GC0XM119440
  • GC0XM119543
  • GC0XM119658
  • GC0XM109109

Summaries for CUL4B Gene

Entrez Gene Summary for CUL4B Gene

  • This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CUL4B Gene

CUL4B (Cullin 4B) is a Protein Coding gene. Diseases associated with CUL4B include mental retardation, x-linked, syndromic 15 and mental retardation, x-linked, with short stature, small testes, muscle wasting, and tremor. Among its related pathways are Class I MHC mediated antigen processing and presentation and Global Genomic NER (GG-NER). GO annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is CUL1.

UniProtKB/Swiss-Prot for CUL4B Gene

  • Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8.

Gene Wiki entry for CUL4B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUL4B Gene

Genomics for CUL4B Gene

Regulatory Elements for CUL4B Gene

Genomic Location for CUL4B Gene

Start:
120,524,589 bp from pter
End:
120,575,829 bp from pter
Size:
51,241 bases
Orientation:
Minus strand

Genomic View for CUL4B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CUL4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUL4B Gene

Proteins for CUL4B Gene

  • Protein details for CUL4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13620-CUL4B_HUMAN
    Recommended name:
    Cullin-4B
    Protein Accession:
    Q13620
    Secondary Accessions:
    • B1APK5
    • B3KVX4
    • B7Z5K8
    • Q6PIE4
    • Q6UP07
    • Q7Z673
    • Q9BY37
    • Q9UEB7
    • Q9UED7

    Protein attributes for CUL4B Gene

    Size:
    913 amino acids
    Molecular mass:
    103982 Da
    Quaternary structure:
    • Component of multiple DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes that seem to be formed of DDB1, CUL4A or CUL4B, RBX1 and a variable substrate recognition component which seems to belong to a protein family described as DCAF (Ddb1- and Cul4-associated factor) or CDW (CUL4-DDB1-associated WD40-repeat) proteins. Component of the DCX(DTL) complex with the putative substrate recognition component DTL. Component of the DCX(DDB2) complex with the putative substrate recognition component DDB2. Part of a complex with RBX1 and TIP120A/CAND1. Interacts with RBX1 GRWD1, MLST8, SMU1, TLE2, TLE3, VPRBP, DDA1, DCAF6, DCAF17, DDB2, DCAF8, TIP120A/CAND1 and TMEM113. Interacts with cyclin E and with importins alpha-1 (KPNA2), alpha-3 (KPNA4), alpha-5 (KPNA1) and beta-1 (KPNB1). May interact with WDR26, WDR51B, SNRNP40, WDR61, WDR76 and WDR5.
    SequenceCaution:
    • Sequence=AAB67315.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAK16812.1; Type=Frameshift; Positions=115; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CUL4B Gene

    Alternative splice isoforms for CUL4B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CUL4B Gene

Proteomics data for CUL4B Gene at MOPED

Post-translational modifications for CUL4B Gene

  • Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.
  • Ubiquitination at Lys240, Lys385, Lys495, Lys582, Lys632, Lys691, and Lys844
  • Modification sites at PhosphoSitePlus

Other Protein References for CUL4B Gene

No data available for DME Specific Peptides for CUL4B Gene

Domains for CUL4B Gene

Suggested Antigen Peptide Sequences for CUL4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13620

UniProtKB/Swiss-Prot:

CUL4B_HUMAN :
  • Q13620
Family:
  • Belongs to the cullin family.
genes like me logo Genes that share domains with CUL4B: view

No data available for Gene Families for CUL4B Gene

Function for CUL4B Gene

Molecular function for CUL4B Gene

UniProtKB/Swiss-Prot Function: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8.

Gene Ontology (GO) - Molecular Function for CUL4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003684 contributes_to damaged DNA binding IDA 22334663
GO:0005515 protein binding IPI 12609982
GO:0031625 ubiquitin protein ligase binding IEA --
genes like me logo Genes that share ontologies with CUL4B: view
genes like me logo Genes that share phenotypes with CUL4B: view

Animal Models for CUL4B Gene

MGI Knock Outs for CUL4B:

Animal Model Products

CRISPR Products

miRNA for CUL4B Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CUL4B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CUL4B Gene

Localization for CUL4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CUL4B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CUL4B Gene COMPARTMENTS Subcellular localization image for CUL4B gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 2

Gene Ontology (GO) - Cellular Components for CUL4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
GO:0031461 cullin-RING ubiquitin ligase complex --
genes like me logo Genes that share ontologies with CUL4B: view

Pathways for CUL4B Gene

genes like me logo Genes that share pathways with CUL4B: view

Pathways by source for CUL4B Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q13620-CUL4B_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for CUL4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair TAS --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0007049 cell cycle NAS 8681378
GO:0019985 translesion synthesis TAS --
GO:0035518 histone H2A monoubiquitination IDA 22334663
genes like me logo Genes that share ontologies with CUL4B: view

Transcripts for CUL4B Gene

Unigene Clusters for CUL4B Gene

Cullin 4B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CUL4B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CUL4B Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: - - - -
SP2: - - - -
SP3:
SP4:
SP5: - -
SP6: -
SP7: - -
SP8:
SP9:

ExUns: 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for CUL4B Gene

GeneLoc Exon Structure for
CUL4B
ECgene alternative splicing isoforms for
CUL4B

Expression for CUL4B Gene

mRNA expression in normal human tissues for CUL4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CUL4B Gene

SOURCE GeneReport for Unigene cluster for CUL4B Gene Hs.102914

genes like me logo Genes that share expressions with CUL4B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CUL4B Gene

Orthologs for CUL4B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CUL4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CUL4B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CUL4B 35
  • 94.31 (n)
  • 98.65 (a)
CUL4B 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CUL4B 35
  • 96.52 (n)
  • 99.55 (a)
CUL4B 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cul4b 35
  • 92.04 (n)
  • 97.71 (a)
Cul4b 16
Cul4b 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CUL4B 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CUL4B 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cul4b 35
  • 92.28 (n)
  • 98.29 (a)
chicken
(Gallus gallus)
Aves CUL4B 35
  • 82.88 (n)
  • 92.05 (a)
CUL4B 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CUL4B 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cul4b 35
  • 81.39 (n)
  • 90.67 (a)
Str.6401 35
zebrafish
(Danio rerio)
Actinopterygii cul4b 35
  • 75.62 (n)
  • 86.69 (a)
cul4b 36
  • 84 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007727 35
  • 62.77 (n)
  • 66.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cul-4 35
  • 60.65 (n)
  • 64.97 (a)
Cul-4 36
  • 62 (a)
OneToMany
cul-4 37
  • 69 (a)
worm
(Caenorhabditis elegans)
Secernentea cul-4 36
  • 31 (a)
OneToMany
cul-4 37
  • 33 (a)
soybean
(Glycine max)
eudicotyledons Gma.6896 35
thale cress
(Arabidopsis thaliana)
eudicotyledons CUL4 35
  • 59.12 (n)
  • 57.24 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.5410 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9784 36
  • 54 (a)
OneToMany
Species with no ortholog for CUL4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CUL4B Gene

ENSEMBL:
Gene Tree for CUL4B (if available)
TreeFam:
Gene Tree for CUL4B (if available)

Paralogs for CUL4B Gene

Paralogs for CUL4B Gene

Selected SIMAP similar genes for CUL4B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CUL4B: view

Variants for CUL4B Gene

Sequence variations from dbSNP and Humsavar for CUL4B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs14279 -- 120,524,806(-) CTGTT(C/T)CAGCT utr-variant-3-prime
rs1057116 -- 120,526,086(-) TGTGT(A/G)TATAT utr-variant-3-prime
rs1801846 -- 120,525,756(-) CCAAA(A/G)TTTTT utr-variant-3-prime
rs2106543 -- 120,570,228(+) CAAAG(C/G)GGGAG intron-variant
rs2285549 -- 120,544,033(+) ATAAA(C/T)GCAAA intron-variant

Relevant External Links for CUL4B Gene

HapMap Linkage Disequilibrium report
CUL4B
Human Gene Mutation Database (HGMD)
CUL4B
Locus Specific Mutation Databases (LSDB)
CUL4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CUL4B Gene

Disorders for CUL4B Gene

(1) OMIM Diseases for CUL4B Gene (300304)

UniProtKB/Swiss-Prot

CUL4B_HUMAN
  • Mental retardation, X-linked, syndromic, 15 (MRXS15) [MIM:300354]: A syndromic form of X-linked mental retardation characterized by severe intellectual deficit associated with short stature, craniofacial dysmorphism, small testes, muscle wasting in lower legs, kyphosis, joint hyperextensibility, pes cavus, small feet, and abnormalities of the toes. Additional neurologic manifestations include speech delay and impairment, tremor, seizures, gait ataxia, hyperactivity and decreased attention span. {ECO:0000269 PubMed:17236139, ECO:0000269 PubMed:17273978, ECO:0000269 PubMed:19377476, ECO:0000269 PubMed:20002452}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for CUL4B Gene

genes like me logo Genes that share disorders with CUL4B: view

Publications for CUL4B Gene

  1. The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A. (PMID: 18593899) Guerrero-Santoro J. … Rapic-Otrin V. (Cancer Res. 2008) 3 4 23
  2. cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. (PMID: 8681378) Kipreos E.T. … Hedgecock E.M. (Cell 1996) 2 3 4
  3. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 3 4
  4. ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. (PMID: 10230407) Ohta T. … Xiong Y. (Mol. Cell 1999) 3 4
  5. Covalent modification of all members of human cullin family proteins by NEDD8. (PMID: 10597293) Hori T. … Tanaka K. (Oncogene 1999) 3 4

Products for CUL4B Gene

  • Addgene plasmids for CUL4B

Sources for CUL4B Gene

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