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Aliases for CUL4A Gene

Aliases for CUL4A Gene

  • Cullin 4A 2 3 5
  • CUL-4A 3 4
  • Cullin-4A 3

External Ids for CUL4A Gene

Previous GeneCards Identifiers for CUL4A Gene

  • GC13P112473
  • GC13P108500
  • GC13P112949
  • GC13P111811
  • GC13P112911
  • GC13P113863
  • GC13P094301

Summaries for CUL4A Gene

Entrez Gene Summary for CUL4A Gene

  • CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009]

GeneCards Summary for CUL4A Gene

CUL4A (Cullin 4A) is a Protein Coding gene. Diseases associated with CUL4A include Xeroderma Pigmentosum, Variant Type and Xeroderma Pigmentosum Group E. Among its related pathways are Nucleotide excision repair and Transcription-Coupled Nucleotide Excision Repair (TC-NER). GO annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is CUL4B.

UniProtKB/Swiss-Prot for CUL4A Gene

  • Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL.

Gene Wiki entry for CUL4A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUL4A Gene

Genomics for CUL4A Gene

Regulatory Elements for CUL4A Gene

Enhancers for CUL4A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13G113182 1.6 Ensembl ENCODE dbSUPER 11.9 -22.0 -21953 6.5 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 PROZ PCID2 CUL4A F10-AS1 KARSP2 F10 GRTP1 F7 LAMP1 ENSG00000269356
GH13G113272 1.5 FANTOM5 Ensembl ENCODE 12 +66.0 66011 3.3 NFIB RAD21 RARA CHAMP1 RFX5 YY1 FOS ZNF263 SMARCC1 ZNF362 LAMP1 PROZ CUL4A GRTP1 PCID2 DCUN1D2-AS DCUN1D2 LDHBP1 LOC105370377
GH13G113393 1.5 Ensembl ENCODE dbSUPER 10.5 +185.7 185740 1.5 HDGF WRNIP1 SIN3A DMAP1 GLI4 ZNF2 ZNF48 GLIS2 ZNF143 ZNF207 GRTP1 GRTP1-AS1 PCID2 CUL4A DCUN1D2-AS DCUN1D2 RASA3 PIR34234
GH13G113175 1.3 Ensembl ENCODE dbSUPER 11.5 -29.7 -29721 5.7 PKNOX1 JUN SIN3A ZIC2 ZFHX2 POLR2A FOS MAFK NFE2L2 EGR2 PROZ PCID2 CUL4A F10-AS1 KARSP2 F10 F7 GRTP1 GRTP1-AS1 ENSG00000269356
GH13G113397 0.8 ENCODE dbSUPER 10.5 +189.8 189842 0.8 GLIS2 NR2F1 MYNN ZIC2 GRTP1 GRTP1-AS1 PCID2 CUL4A DCUN1D2-AS DCUN1D2 PIR34234 LOC101928841
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CUL4A on UCSC Golden Path with GeneCards custom track

Promoters for CUL4A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000066105 1107 3001 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3

Genomic Location for CUL4A Gene

Chromosome:
13
Start:
113,208,193 bp from pter
End:
113,267,108 bp from pter
Size:
58,916 bases
Orientation:
Plus strand

Genomic View for CUL4A Gene

Genes around CUL4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CUL4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CUL4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUL4A Gene

Proteins for CUL4A Gene

  • Protein details for CUL4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13619-CUL4A_HUMAN
    Recommended name:
    Cullin-4A
    Protein Accession:
    Q13619
    Secondary Accessions:
    • A2A2W2
    • O75834
    • Q589T6
    • Q5TC62
    • Q6UP08
    • Q9UP17

    Protein attributes for CUL4A Gene

    Size:
    759 amino acids
    Molecular mass:
    87680 Da
    Quaternary structure:
    • Component of multiple DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes that seem to consist of DDB1, CUL4A or CUL4B, RBX1 and a variable substrate recognition component which seems to belong to a protein family described as DCAF (Ddb1- and Cul4-associated factor) or CDW (CUL4-DDB1-associated WD40-repeat) proteins. Component of the CSA complex (DCX(ERCC8) complex) containing ERCC8, RBX1, DDB1 and CUL4A; the CSA complex interacts with RNA polymerase II; upon UV irradiation it interacts with the COP9 signalosome and preferentially with the hyperphosphorylated form of RNA polymerase II. Component of the DCX(DET1-COP1) complex with the substrate recognition component DET1 and COP1. Component of the DCX(DDB2) complex with the substrate recognition component DDB2. Component of the DCX(DTL) complex with the putative substrate recognition component DTL. Interacts with DDB1, RBX1, RNF7, CTD1, TIP120A/CAND1, SKP2, CDKN1B, MDM2, TP53 and HOXA9. Interacts with DDB2; the interactions with DDB2 and CAND1 are mutually exclusive. Interacts with VPRBP, DTL, DDA1, DCAF6, DCAF4, DCAF16, DCAF17, DET1, WDTC1, DCAF5, DCAF11, WDR24A, RFWD2, PAFAH1B1, ERCC8, GRWD1, FBXW5, RBBP7, GNB2, WSB1, WSB2, NUP43, PWP1, FBXW8, ATG16L1, KATNB1, RBBP4, RBBP5, LRWD1 and DCAF8. May interact with WDR26, WDR51B, SNRNP40, WDR61, WDR76, WDR5. Can self-associate. Interacts (when neddylated) with ARIH1; leading to activate the E3 ligase activity of ARIH1 (PubMed:24076655).
    • (Microbial infection) Interacts with Epstein-Barr virus BPLF1.

    Three dimensional structures from OCA and Proteopedia for CUL4A Gene

    Alternative splice isoforms for CUL4A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CUL4A Gene

Post-translational modifications for CUL4A Gene

  • (Microbial infection) Deneddylated by Epstein-Barr virus BPLF1 leading to a S-phase-like environment that is required for efficient replication of the viral genome.
  • Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.
  • Ubiquitination at isoforms=33 and isoforms=104
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CUL4A Gene

Domains & Families for CUL4A Gene

Gene Families for CUL4A Gene

Suggested Antigen Peptide Sequences for CUL4A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13619

UniProtKB/Swiss-Prot:

CUL4A_HUMAN :
  • Belongs to the cullin family.
Family:
  • Belongs to the cullin family.
genes like me logo Genes that share domains with CUL4A: view

Function for CUL4A Gene

Molecular function for CUL4A Gene

UniProtKB/Swiss-Prot Function:
Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL.

Gene Ontology (GO) - Molecular Function for CUL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12504025
GO:0031625 ubiquitin protein ligase binding IBA --
GO:0061630 contributes_to ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with CUL4A: view
genes like me logo Genes that share phenotypes with CUL4A: view

Animal Models for CUL4A Gene

MGI Knock Outs for CUL4A:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CUL4A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CUL4A Gene

Localization for CUL4A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CUL4A gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for CUL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0031461 cullin-RING ubiquitin ligase complex IEA --
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex IDA 12732143
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IDA 18381890
genes like me logo Genes that share ontologies with CUL4A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CUL4A Gene

Pathways & Interactions for CUL4A Gene

genes like me logo Genes that share pathways with CUL4A: view

Pathways by source for CUL4A Gene

UniProtKB/Swiss-Prot Q13619-CUL4A_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for CUL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS 8681378
GO:0000715 nucleotide-excision repair, DNA damage recognition TAS --
GO:0000717 nucleotide-excision repair, DNA duplex unwinding TAS --
GO:0001701 in utero embryonic development IEA --
GO:0006281 DNA repair IEA --
genes like me logo Genes that share ontologies with CUL4A: view

No data available for SIGNOR curated interactions for CUL4A Gene

Drugs & Compounds for CUL4A Gene

No Compound Related Data Available

Transcripts for CUL4A Gene

Unigene Clusters for CUL4A Gene

Cullin 4A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CUL4A

Alternative Splicing Database (ASD) splice patterns (SP) for CUL4A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a ·
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - -
SP6: - - - -
SP7:
SP8: - - - - - -
SP9: - - - - -
SP10: - - -
SP11: - - -
SP12: - - - -
SP13: -

ExUns: 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b · 26c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for CUL4A Gene

GeneLoc Exon Structure for
CUL4A
ECgene alternative splicing isoforms for
CUL4A

Expression for CUL4A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CUL4A Gene

mRNA differential expression in normal tissues according to GTEx for CUL4A Gene

This gene is overexpressed in Muscle - Skeletal (x5.2).

Protein differential expression in normal tissues from HIPED for CUL4A Gene

This gene is overexpressed in Lymph node (11.3) and Peripheral blood mononuclear cells (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CUL4A Gene



Protein tissue co-expression partners for CUL4A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CUL4A Gene:

CUL4A

SOURCE GeneReport for Unigene cluster for CUL4A Gene:

Hs.339735

Evidence on tissue expression from TISSUES for CUL4A Gene

  • Lung(4.5)
  • Liver(4.3)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with CUL4A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CUL4A Gene

Orthologs for CUL4A Gene

This gene was present in the common ancestor of animals.

Orthologs for CUL4A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CUL4A 34 35
  • 99.65 (n)
oppossum
(Monodelphis domestica)
Mammalia CUL4A 35
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CUL4A 35
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CUL4A 34 35
  • 87.83 (n)
mouse
(Mus musculus)
Mammalia Cul4a 34 16 35
  • 86.21 (n)
rat
(Rattus norvegicus)
Mammalia Cul4a 34
  • 86.17 (n)
cow
(Bos Taurus)
Mammalia CUL4A 34 35
  • 83.88 (n)
chicken
(Gallus gallus)
Aves CUL4A 34 35
  • 80.68 (n)
lizard
(Anolis carolinensis)
Reptilia CUL4A 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cul4a 34
  • 75.08 (n)
zebrafish
(Danio rerio)
Actinopterygii cul4a 35
  • 79 (a)
OneToOne
zgc64071 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6469 34
fruit fly
(Drosophila melanogaster)
Insecta cul-4 36
  • 68 (a)
Cul-4 35
  • 60 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cul-4 36 35
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9784 35
  • 54 (a)
OneToMany
Species where no ortholog for CUL4A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CUL4A Gene

ENSEMBL:
Gene Tree for CUL4A (if available)
TreeFam:
Gene Tree for CUL4A (if available)

Paralogs for CUL4A Gene

Paralogs for CUL4A Gene

(4) SIMAP similar genes for CUL4A Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CUL4A Gene

genes like me logo Genes that share paralogs with CUL4A: view

Variants for CUL4A Gene

Sequence variations from dbSNP and Humsavar for CUL4A Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000026576 -- 113,248,368(+) CTCAG(A/G)GATTC intron-variant
rs1000048623 -- 113,224,309(+) GATCG(C/T)ACCAC intron-variant
rs1000084944 -- 113,265,404(+) TTTAA(C/T)TGAGG downstream-variant-500B
rs1000132352 -- 113,249,055(+) CCTCC(C/T)CAGCC intron-variant
rs1000134625 -- 113,219,725(+) AACCC(A/G)TAACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CUL4A Gene

Variant ID Type Subtype PubMed ID
dgv1044n106 CNV insertion 24896259
dgv3434n54 CNV gain 21841781
dgv3435n54 CNV loss 21841781
dgv3436n54 CNV gain+loss 21841781
dgv3437n54 CNV loss 21841781
esv1087624 CNV insertion 17803354
esv1282521 CNV insertion 17803354
esv1574408 CNV insertion 17803354
esv1654591 CNV insertion 17803354
esv25141 CNV loss 19812545
esv2748266 CNV deletion 23290073
esv2748267 CNV deletion 23290073
esv2748268 CNV deletion 23290073
esv2748269 CNV deletion 23290073
esv2748270 CNV deletion 23290073
esv2748271 CNV deletion 23290073
esv3431454 CNV duplication 20981092
nsv1045409 CNV gain 25217958
nsv1048814 CNV gain 25217958
nsv1143402 CNV deletion 24896259
nsv1143602 CNV deletion 24896259
nsv1144704 CNV deletion 24896259
nsv1148358 CNV deletion 26484159
nsv1150383 CNV deletion 26484159
nsv1160149 CNV duplication 26073780
nsv1194 CNV insertion 18451855
nsv509520 CNV insertion 20534489
nsv518044 CNV gain 19592680
nsv563302 CNV loss 21841781
nsv563305 CNV gain 21841781
nsv563314 CNV gain 21841781
nsv563316 CNV loss 21841781

Variation tolerance for CUL4A Gene

Residual Variation Intolerance Score: 10.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.85; 83.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CUL4A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CUL4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CUL4A Gene

Disorders for CUL4A Gene

MalaCards: The human disease database

(2) MalaCards diseases for CUL4A Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
xeroderma pigmentosum, variant type
  • de sanctis-cacchione syndrome
xeroderma pigmentosum group e
  • xeroderma pigmentosum v
- elite association - COSMIC cancer census association via MalaCards
Search CUL4A in MalaCards View complete list of genes associated with diseases

Relevant External Links for CUL4A

Genetic Association Database (GAD)
CUL4A
Human Genome Epidemiology (HuGE) Navigator
CUL4A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CUL4A
genes like me logo Genes that share disorders with CUL4A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CUL4A Gene

Publications for CUL4A Gene

  1. Cul4A and DDB1 associate with Skp2 to target p27Kip1 for proteolysis involving the COP9 signalosome. (PMID: 16537899) Bondar T. … Raychaudhuri P. (Mol. Cell. Biol. 2006) 3 4 22 64
  2. DDB2, the xeroderma pigmentosum group E gene product, is directly ubiquitylated by Cullin 4A-based ubiquitin ligase complex. (PMID: 15811626) Matsuda N. … Tanaka K. (DNA Repair 2005) 3 4 22 64
  3. Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. (PMID: 14739464) Wertz I.E. … Dixit V.M. (Science 2004) 3 4 22 64
  4. Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. (PMID: 15448697) Hu J. … Xiong Y. (Nat. Cell Biol. 2004) 3 4 22 64
  5. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. (PMID: 12732143) Groisman R. … Nakatani Y. (Cell 2003) 3 4 22 64

Products for CUL4A Gene

  • Addgene plasmids for CUL4A

Sources for CUL4A Gene

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