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CUL4A Gene

protein-coding   GIFtS: 63
GCID: GC13P113863

Cullin 4A

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cullin 4A1 2
CUL-4A2 3
cullin-4A2

External Ids:    HGNC: 25541   Entrez Gene: 84512   Ensembl: ENSG000001398427   OMIM: 6031375   UniProtKB: Q136193   

Export aliases for CUL4A gene to outside databases

Previous GC identifers: GC13P112473 GC13P108500 GC13P112949 GC13P111811 GC13P112911 GC13P094301


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CUL4A Gene:
CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response
proteins (Liu et al., 2009 (PubMed 19481525)).(supplied by OMIM, Oct 2009)

GeneCards Summary for CUL4A Gene:
CUL4A (cullin 4A) is a protein-coding gene. Diseases associated with CUL4A include glomuvenous malformation, and xeroderma pigmentosum. GO annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is CUL1.

UniProtKB/Swiss-Prot: CUL4A_HUMAN, Q13619
Function: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the
ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the
substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is
dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin
subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the
variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs
ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition
during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by
facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL)
plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response
to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is
involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs
autoubiquitination of DTL

Gene Wiki entry for CUL4A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NC_018924.2  NT_027140.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the CUL4A gene promoter:
         CREB   HEN1   Nkx6-1   deltaCREB   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCUL4A promoter sequence
   Search Chromatin IP Primers for CUL4A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CUL4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

CUL4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CUL4A gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P113863:  view genomic region     (about GC identifiers)

Start:
113,862,552 bp from pter      End:
113,919,399 bp from pter
Size:
56,848 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CUL4A_HUMAN, Q13619 (See protein sequence)
Recommended Name: Cullin-4A  
Size: 759 amino acids; 87680 Da
Subunit: Component of multiple DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes that seem to consist of
DDB1, CUL4A or CUL4B, RBX1 and a variable substrate recognition component which seems to belong to a protein
family described as DCAF (Ddb1- and Cul4-associated factor) or CDW (CUL4-DDB1-associated WD40-repeat) proteins.
Component of the CSA complex (DCX(ERCC8) complex) containing ERCC8, RBX1, DDB1 and CUL4A; the CSA complex
interacts with RNA polymerase II; upon UV irradiation it interacts with the COP9 signalosome and preferentially
with the hyperphosphorylated form of RNA polymerase II. Component of the DCX(DET1-COP1) complex with the
substrate recognition component DET1 and COP1. Component of the DCX(DDB2) complex with the substrate recognition
component DDB2. Component of the DCX(DTL) complex with the putative substrate recognition component DTL.
Interacts with DDB1, RBX1, RNF7, CTD1, TIP120A/CAND1, SKP2, CDKN1B, MDM2, TP53 and HOXA9. Interacts with DDB2;
the interactions with DDB2 and CAND1 are mutually exclusive. Interacts with VPRBP, DTL, DDA1, DCAF6, DCAF4,
DCAF16, DCAF17, DET1, WDTC1, DCAF5, DCAF11, WDR24A, RFWD2, PAFAH1B1, ERCC8, GRWD1, FBXW5, RBBP7, GNB2, WSB1,
WSB2, NUP43, PWP1, FBXW8, ATG16L1, KATNB1, RBBP4, RBBP5, LRWD1 and DCAF8. May interact with WDR26, WDR51B,
SNRNP40, WDR61, WDR76, WDR5. Can self-associate. Interacts with Epstein-Barr virus BPLF1
2 PDB 3D structures from and Proteopedia for CUL4A:
2HYE (3D)        4A0K (3D)    
Secondary accessions: A2A2W2 O75834 Q589T6 Q5TC62 Q6UP08 Q9UP17
Alternative splicing: 2 isoforms:  Q13619-1   Q13619-2   

Explore the universe of human proteins at neXtProt for CUL4A: NX_Q13619

Explore proteomics data for CUL4A at MOPED

Post-translational modifications: 

  • Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex (By similarity). Deneddylated
    by Epstein-Barr virus BPLF1 leading to a S-phase-like environment that is required for efficient replication of
    the viral genome1
  • Ubiquitination2 at Lys33, Lys104, Lys496
  • Modification sites at PhosphoSitePlus

  • See CUL4A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001008895.1  NP_001265442.1  NP_001265443.1  NP_003580.1  

    ENSEMBL proteins: 
     ENSP00000322132   ENSP00000364589   ENSP00000364590   ENSP00000389118  

    CUL4A Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CUL4A
    OriGene Custom MassSpec
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    GenScript Custom Purified and Recombinant Proteins Services for CUL4A
    Novus Biologicals CUL4A Proteins
    Novus Biologicals CUL4A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CUL4A

    CUL4A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
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    Novus Biologicals CUL4A Antibodies
    Abcam antibodies for CUL4A
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    ThermoFisher Antibodies for CUL4A
    LSBio Antibodies in human, mouse, rat for CUL4A

    CUL4A Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CUL4A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CUL4A
    Cloud-Clone Corp. CLIAs for CUL4A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR016159 Cullin_repeat-like_dom
     IPR019559 Cullin_neddylation_domain
     IPR016157 Cullin_CS
     IPR001373 Cullin_N
     IPR011991 WHTH_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q13619

    ProtoNet protein and cluster: Q13619

    1 Blocks protein domain: IPB001373 Cullin

    UniProtKB/Swiss-Prot: CUL4A_HUMAN, Q13619
    Similarity: Belongs to the cullin family


    CUL4A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CUL4A_HUMAN, Q13619
    Function: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the
    ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the
    substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is
    dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin
    subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the
    variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs
    ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition
    during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by
    facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL)
    plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response
    to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is
    involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs
    autoubiquitination of DTL

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12504025
    GO:0031625ubiquitin protein ligase binding IEA--
         
    CUL4A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CUL4A:
     Increased cell death in HCT116 

         11 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Cul4a):
     cellular  digestive/alimentary  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  reproductive system 
     tumorigenesis 

    CUL4A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CUL4A: Cul4atm1.2Pra Cul4atm1.2Pz Cul4a/Pcid2Cul4a/tm1Ktc

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CUL4A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CUL4A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CUL4A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CUL4A

    miRNA
    Products:
        
    miRTarBase miRNAs that target CUL4A:
    hsa-mir-18a-5p (MIRT050685), hsa-mir-193b-3p (MIRT041473), hsa-mir-103a-3p (MIRT027107), hsa-mir-23b-3p (MIRT046251), hsa-mir-16-5p (MIRT031821), hsa-mir-106a-5p (MIRT048313), hsa-mir-615-3p (MIRT039946)

    Block miRNA regulation of human, mouse, rat CUL4A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CUL4A (see all 28):
    hsa-miR-323-3p hsa-miR-142-5p hsa-miR-16-2* hsa-miR-137 hsa-miR-181c hsa-miR-548k hsa-miR-4305 hsa-miR-1271
    SwitchGear 3'UTR luciferase reporter plasmidCUL4A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CUL4A
    Predesigned siRNA for gene silencing in human, mouse, rat CUL4A

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CUL4A

    Clone
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    OriGene clones in human, mouse for CUL4A (see all 12)
    OriGene ORF clones in mouse, rat for CUL4A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CUL4A (NM_003589)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CUL4A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUL4A

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CUL4A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUL4A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    golgi apparatus2
    nucleus2
    plasma membrane2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031461cullin-RING ubiquitin ligase complex ----
    GO:0031464Cul4A-RING ubiquitin ligase complex IDA12732143
    GO:0080008Cul4-RING ubiquitin ligase complex IDA18381890

    CUL4A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CUL4A About    
    See pathways by source

    SuperPathContained pathways About
    1Global Genomic NER (GG-NER)
    Nucleotide excision repair0.69
    2Class I MHC mediated antigen processing and presentation
    Ubiquitin mediated proteolysis0.35
    3Protein Stability
    Protein Stability

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CUL4A
        Protein Stability


    2 Kegg Pathways  (Kegg details for CUL4A):
        Nucleotide excision repair
    Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: CUL4A_HUMAN, Q13619
    Pathway: Protein modification; protein ubiquitination


    CUL4A for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CUL4A: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CUL4A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CUL4A (Q136191, 2, 3 ENSP000003645894) via UniProtKB, MINT, STRING, and/or I2D (see all 252)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4LP628053, ENSP000003482584I2D: score=1 STRING: ENSP00000348258
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS8681378
    GO:0006281DNA repair IEA--
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0007050cell cycle arrest TAS8681378
    GO:0007346regulation of mitotic cell cycle ----

    CUL4A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CUL4A



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CUL4A gene (4 alternative transcripts): 
    NM_001008895.2  NM_001278513.1  NM_001278514.1  NM_003589.2  

    Unigene Cluster for CUL4A:

    Cullin 4A
    Hs.339735  [show with all ESTs]
    Unigene Representative Sequence: NM_001008895
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326335(uc010agu.3 uc010tjz.2) ENST00000375440 ENST00000488558
    ENST00000474116 ENST00000494985 ENST00000463426 ENST00000498562 ENST00000470067
    ENST00000472083 ENST00000375441 ENST00000451881(uc021rmu.1 uc021rmv.1)

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat CUL4A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CUL4A (see all 28):
    hsa-miR-323-3p hsa-miR-142-5p hsa-miR-16-2* hsa-miR-137 hsa-miR-181c hsa-miR-548k hsa-miR-4305 hsa-miR-1271
    SwitchGear 3'UTR luciferase reporter plasmidCUL4A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CUL4A
    Clone
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    OriGene ORF clones in mouse, rat for CUL4A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CUL4A (NM_003589)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CUL4A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUL4A
    Primer
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    OriGene qPCR primer pairs and template standards for CUL4A
    OriGene qSTAR qPCR primer pairs in human, mouse for CUL4A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CUL4A
      QuantiTect SYBR Green Assays in human, mouse, rat CUL4A
      QuantiFast Probe-based Assays in human, mouse, rat CUL4A

    Additional mRNA sequence: 

    AB012193.1 AB178950.1 AF077188.1 AK023430.1 AK126278.1 AK296700.1 AK314835.1 AL833355.1 
    AY365124.1 BC008308.1 BC015166.1 U58090.1 

    Selected DOTS entries (see all 29):

    DT.97826298  DT.95133634  DT.92000929  DT.97783600  DT.100828097  DT.100804102  DT.413424  DT.87016277 
    DT.106271  DT.100828091  DT.97794285  DT.101985114  DT.40208642  DT.95133622  DT.101975926  DT.65286724 
    DT.92063363  DT.100828098  DT.91751229  DT.100828092  DT.100689792  DT.100735373  DT.101971879  DT.120776861 

    Selected AceView cDNA sequences (see all 424):

    BQ006729 BM994332 AY365124 H95295 CA434329 CA429604 AI698068 AA468701 
    BQ945844 CB045592 BU187920 AA744468 AA844019 BI259757 CD171883 CA436829 
    BQ691960 AI355132 BQ672870 AI222827 AA150317 AA831848 W67977 AI198557 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CUL4A (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a ·
    SP1:                          -                 -           -     -                       -     -     -                             -                           
    SP2:                                            -           -     -                       -     -                                   -                           
    SP3:                                      -     -           -     -                       -     -     -                             -                           
    SP4:        -     -     -     -                 -           -     -                       -     -     -                                                         
    SP5:              -     -     -                 -           -     -                                                                                             

    ExUns: 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b · 26c
    SP1:                                                                  
    SP2:                                                                  
    SP3:                                                                  
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for CUL4A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CUL4A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATATGTGGTC
    CUL4A Expression
    About this image

    CUL4A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CUL4A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.339735
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CUL4A: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CUL4A gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cul4a1 , 5 cullin 4A1, 5 86.21(n)1
    95.13(a)1
      8 (5.73 cM)5
    993751  NM_146207.21  NP_666319.21 
     131056215 
    chicken
    (Gallus gallus)
    Aves CUL4A1 cullin 4A 80.68(n)
    91.04(a)
      418744  XM_003640529.2  XP_003640577.1 
    lizard
    (Anolis carolinensis)
    Reptilia CUL4A6
    cullin 4A
    80(a)
    1 ↔ 1
    3(106014173-106053439)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cul4a1 cullin 4A 75.08(n)
    84.2(a)
      548647  NM_001015893.1  NP_001015893.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc640712 similar to cullin 4A 75.59(n)   394002  BC054607.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cul-43 ubiquitin-protein ligase 68(a)   44B1   --
    worm
    (Caenorhabditis elegans)
    Secernentea cul-43 Expression: all stages 33(a)   II(7302044-7305464)   --
    soybean
    (Glycine max)
    eudicotyledons CA783962.12   -- 72.05(n)    CA783962.1 


    ENSEMBL Gene Tree for CUL4A (if available)
    TreeFam Gene Tree for CUL4A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CUL4A gene
    CUL12  CUL32  CUL4B2  CUL22  CUL52  
    4 SIMAP similar genes for CUL4A using alignment to 1 protein entry:     CUL4A_HUMAN:
    CUL4B    CUL3    CUL1    CUL2

    CUL4A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CUL4A
    PGOHUM00000245668


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CUL4A (see all 1353)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1863931571,2
    --113865073(+) ATGTGC/TCATAC 2 -- int10--------
    rs38414251,2
    C--113865114(-) AAAAA-/AAGTTTT 2 -- int10--------
    rs669285051,2
    C--113865114(+) AAAAC-/TTTTTTT 2 -- int10--------
    rs786471851,2
    C,F--113865153(+) AAATTA/TTAAAA 2 -- int11Minor allele frequency- T:0.03WA 118
    rs756934471,2
    C,F--113865163(+) AAATAC/TAAAAA 2 -- int11Minor allele frequency- T:0.03WA 118
    rs735810191,2
    C,F--113865306(+) ATATAA/GTGTGC 2 -- int12Minor allele frequency- G:0.06WA 120
    rs79846651,2
    C,F,A,H--113865336(+) gatgcA/Gtgcag 2 -- int115Minor allele frequency- G:0.04NS EA NA WA 1944
    rs786278291,2
    --113865475(+) GTCCCC/GCATTT 2 -- int10--------
    rs1504211181,2
    --113865607(+) TGTGAC/TTGTAA 2 -- int10--------
    rs726652171,2
    C,F--113865695(+) TGGGGT/GTTTTT 2 -- int11Minor allele frequency- G:0.01NA 120

    HapMap Linkage Disequilibrium report for CUL4A (113862552 - 113919399 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CUL4A (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2748271CNV Deletion23290073
    esv2748267CNV Deletion23290073
    esv2748268CNV Deletion23290073
    esv2748269CNV Deletion23290073
    esv2748266CNV Deletion23290073
    esv2748270CNV Deletion23290073
    nsv1194CNV Insertion18451855
    esv1654591CNV Insertion17803354
    esv1574408CNV Insertion17803354
    nsv509520CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CUL4A
    DNA2.0 Custom Variant and Variant Library Synthesis for CUL4A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603137    OMIM disorders: --

    16 diseases for CUL4A:    
    About MalaCards
    glomuvenous malformation    xeroderma pigmentosum    malignant pleural mesothelioma    cockayne syndrome
    pheochromocytoma    lung adenocarcinoma    hiv-1    intellectual disability
    hepatitis b    hypoxia    adenocarcinoma    hepatocellular carcinoma
    hepatitis    prostate cancer    prostatitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for CUL4A:
    Xeroderma pigmentosum

    CUL4A for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for CUL4A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    xeroderma pigmentosum 79.9 1 11564859 (1)
    tumors 0 1 12878869 (1)

    Genetic Association Database (GAD): CUL4A
    Human Genome Epidemiology (HuGE) Navigator: CUL4A (1 document)

    Export disorders for CUL4A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CUL4A gene, integrated from 10 sources (see all 183):
    (articles sorted by number of sources associating them with CUL4A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. (PubMed id 8681378)1, 2, 3 Kipreos E.T.... Hedgecock E.M. (Cell 1996)
    2. Cul4A and DDB1 associate with Skp2 to target p27Kip1 for proteolysis involving the COP9 signalosome. (PubMed id 16537899)1, 2, 9 Bondar T....Raychaudhuri P. (Mol. Cell. Biol. 2006)
    3. DDB2, the xeroderma pigmentosum group E gene product, is directly ubiquitylated by Cullin 4A-based ubiquitin ligase complex. (PubMed id 15811626)1, 2, 9 Matsuda N.... Tanaka K. (DNA Repair 2005)
    4. Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. (PubMed id 15448697)1, 2, 9 Hu J.... Xiong Y. (Nat. Cell Biol. 2004)
    5. Covalent modification of all members of human cullin family proteins by NEDD8. (PubMed id 10597293)1, 2, 9 Hori T.... Tanaka K. (Oncogene 1999)
    6. A new NEDD8-ligating system for cullin-4A. (PubMed id 9694792)1, 2, 9 Osaka F.... Kato S. (Genes Dev. 1998)
    7. Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. (PubMed id 14739464)1, 2, 9 Wertz I.E.... Dixit V.M. (Science 2004)
    8. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. (PubMed id 12732143)1, 2, 9 Groisman R.... Nakatani Y. (Cell 2003)
    9. A Cul4 E3 ubiquitin ligase regulates histone hand-off during nucleosome assembly. (PubMed id 24209620)1, 2 Han J.... Zhang Z. (Cell 2013)
    10. Orc2 protects ORCA from ubiquitin-mediated degradation. (PubMed id 22935713)1, 2 Shen Z. and Prasanth S.G. (Cell Cycle 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8451 HGNC: 2554 AceView: CUL4A Ensembl:ENSG00000139842 euGenes: HUgn8451
    ECgene: CUL4A Kegg: 8451 H-InvDB: CUL4A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CUL4A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CUL4A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CUL4A gene:
    Search GeneIP for patents involving CUL4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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