CUL4A Gene
protein-coding GIFtS: 61
GCID: GC13P113863
|
|
cullin 4A
| |
Aliases
for CUL4A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cullin 4A1 2 | | CUL-4A2 3 | | Cullin-4A1 |
Export aliases for CUL4A gene to outside databasesPrevious GC identifers: GC13P112473 GC13P108500 GC13P112949 GC13P111811 GC13P112911 GC13P094301 |
Summaries
for CUL4A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CUL4A:
CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-responseproteins (Liu et al., 2009 (PubMed 19481525)).(supplied by OMIM, Oct 2009)
UniProtKB/Swiss-Prot: CUL4A_HUMAN, Q13619Function: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate theubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute tocatalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligaseactivity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association ofthe deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligasecomplex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN.DCX(DDB2) directs ubiquitination of XPC. In association with RBX1, DDB1 and DDB2 is required for histone H3 andhistone H4 ubiquitination in response to ultraviolet and may be important for subsequent DNA repair. DCX(DTL) plays arole in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response toradiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved inubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9
Gene Wiki entry for CUL4A
|
Genomic Views
for CUL4A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_027140.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CUL4A gene promoter:
CREB HEN1 Nkx6-1 deltaCREB C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for CUL4A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CUL4A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q34 Ensembl cytogenetic band: 13q34 HGNC cytogenetic band: 13q34CUL4A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P113863: view genomic region
(about GC identifiers)
Start:
|
113,862,552 bp from pter |
End:
|
113,919,399 bp from pter |
Size:
|
56,848 bases |
Orientation:
|
plus strand |
|
Proteins
for CUL4A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CUL4A_HUMAN, Q13619 (See
protein sequence)Recommended Name: Cullin-4A Size: 759 amino acids; 87680 Da
Subunit: Component of multiple DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes that seem to consist ofDDB1, CUL4A or CUL4B, RBX1 and a variable substrate recognition component which seems to belong to a protein familydescribed as DCAF (Ddb1- and Cul4-associated factor) or CDW (CUL4-DDB1-associated WD40-repeat) proteins. Component ofthe CSA complex (DCX(ERCC8) complex) containing ERCC8, RBX1, DDB1 and CUL4A; the CSA complex interacts with RNApolymerase II; upon UV irradiation it interacts with the COP9 signalosome and preferentially with thehyperphosphorylated form of RNA polymerase II. Component of the DCX(DET1-COP1) complex with the substrate recognitioncomponent DET1 and COP1. Component of the DCX(DDB2) complex with the substrate recognition component DDB2. Componentof the DCX(DTL) complex with the putative substrate recognition component DTL. Interacts with DDB1, RBX1, RNF7, CTD1,TIP120A/CAND1, SKP2, CDKN1B, MDM2, TP53 and HOXA9. Interacts with DDB2; the interactions with DDB2 and CAND1 aremutually exclusive. Interacts with VPRBP, DTL, DDA1, DCAF6, DCAF4, DCAF16, DCAF17, DET1, WDTC1, DCAF5, DCAF11, WDR24A,RFWD2, PAFAH1B1, ERCC8, GRWD1, FBXW5, RBBP7, GNB2, WSB1, WSB2, NUP43, PWP1, FBXW8, ATG16L1, KATNB1, RBBP4, RBBP5 andDCAF8. May interact with WDR26, WDR51B, SNRNP40, WDR61, WDR76, WDR5. Can self-associate. Interacts with Epstein-Barrvirus BPLF1
2 PDB 3D structures from  and Proteopedia  for CUL4A:2HYE (3D)
4A0K (3D)
Secondary accessions: A2A2W2 O75834 Q589T6 Q5TC62 Q6UP08 Q9UP17Alternative splicing: 2 isoforms: Q13619-1 Q13619-2 Explore the universe of human proteins at neXtProt for CUL4A: NX_Q13619
Post-translational modifications:
Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex (By similarity). Deneddylated byEpstein-Barr virus BPLF1 leading to a S-phase-like environment that is required for efficient replication of the viralgenome1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13619
CUL4A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001008895.1 NP_003580.1
ENSEMBL proteins: ENSP00000322132 ENSP00000364589 ENSP00000364590 ENSP00000389118
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0031464 | Cul4A-RING ubiquitin ligase complex |
IDA | -- | | GO:0080008 | Cul4-RING ubiquitin ligase complex |
IDA | 18381890 |
CUL4A for ontologies About GeneDecksing
CUL4A Antibody Products:
Assay Products for CUL4A: |
Protein
Domains /
Families
for CUL4A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CUL4A for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q13619ProtoNet protein and cluster: Q13619 1 Blocks protein family: IPB001373 Cullin
UniProtKB/Swiss-Prot: CUL4A_HUMAN, Q13619Similarity: Belongs to the cullin family |
Function
for CUL4A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CUL4A_HUMAN, Q13619Function: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate theubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute tocatalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligaseactivity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association ofthe deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligasecomplex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN.DCX(DDB2) directs ubiquitination of XPC. In association with RBX1, DDB1 and DDB2 is required for histone H3 andhistone H4 ubiquitination in response to ultraviolet and may be important for subsequent DNA repair. DCX(DTL) plays arole in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response toradiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved inubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CUL4A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CUL4A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for CUL4A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUL4A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUL4A |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
CUL4A for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CUL4A:
Animal Models:
Mouse knock-outs for CUL4A: Cul4atm1.2Pra Cul4atm1.2Pz Cul4a/Pcid2Cul4a/tm1Ktc
11 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Cul4a):
CUL4A for phenotypes About GeneDecksing
|
Pathways & Interactions
for CUL4A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Protein Stability | | | 2 | Global Genomic NER (GG-NER) | | | 3 | Antigen processing: Ubiquitination & Proteasome degradation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for CUL4A
2 
Kegg Pathways (Kegg details for CUL4A):
UniProtKB/Swiss-Prot: CUL4A_HUMAN, Q13619Pathway: Protein modification; protein ubiquitination
CUL4A for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CUL4A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/209 Interacting proteins for CUL4A (Q136191, 2, 3 ENSP000003645894) via UniProtKB, MINT, STRING, and/or I2D (see all 209)
About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table
CUL4A for ontologies About GeneDecksing
|
Drugs & Compounds
for CUL4A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CUL4A
Search CenterWatch for drugs/clinical trials and news about CUL4A
|
Transcripts
for CUL4A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CUL4A gene (2 alternative transcripts): NM_001008895.1 NM_003589.2 Unigene Cluster for CUL4A: Cullin 4A Hs.339735 [show with all ESTs]Unigene Representative Sequence: NM_00100889511 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000326335(uc010agu.3 uc010tjz.2) ENST00000375440 ENST00000488558
ENST00000474116 ENST00000494985 ENST00000463426 ENST00000498562 ENST00000470067
ENST00000472083 ENST00000375441 ENST00000451881(uc021rmu.1 uc021rmv.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CUL4A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CUL4A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CUL4A (NM_003589) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CUL4A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUL4A |
Additional cDNA sequence: AB012193.1 AB178950.1 AF077188.1 AK023430.1 AK126278.1 AK296700.1 AK314835.1 AL833355.1 AY365124.1 BC008308.1 BC015166.1 U58090.1 24/29 DOTS entries (see all 29): DT.97826298 DT.95133634 DT.92000929 DT.97783600 DT.100828097 DT.100804102 DT.413424 DT.87016277 DT.106271 DT.100828091 DT.97794285 DT.101985114 DT.40208642 DT.95133622 DT.101975926 DT.65286724 DT.92063363 DT.100828098 DT.91751229 DT.100828092 DT.100689792 DT.100735373 DT.101971879 DT.120776861 24/424 AceView cDNA sequences (see all 424): AA844019 AA150317 AA468701 H95295 BU620946 CR610339 BI259757 CB045592 AA331530 AA319020 AI198557 BU686345 CR616294 CK300635 AA361397 BG723380 AL532255 AV709009 CR603374 BX095135 BC015166 AA832183 BU147437 BX439434
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for CUL4A (see all 13) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · |
|---|
|
| SP1: | | | | | | | | | - | | | | | | - | | | | - | | - | | | | | | | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | | | - | | - | | | | | | | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | - | | - | | - | | - | | | | | | - | | | | - | | - | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | - | | - | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 18b | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26a | · | 26b | · | 26c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CUL4A
|
Expression
for CUL4A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CUL4A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATATGTGGTC
About this image
See CUL4A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CUL4A
SOURCE GeneReport for Unigene cluster: Hs.339735
SABiosciences Expression via Pathway-Focused PCR Arrays including CUL4A:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CUL4A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CUL4A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CUL4A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CUL4A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUL4A |
Orthologs
for CUL4A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CUL4A gene from 7/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CUL4A1 |
cullin 4A |
80.85(n)
91.3(a) |
|
418744 XM_003640529.1 XP_003640577.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CUL4A6 |
-- |
80(a) |
1 ↔ 1 |
3(106014476-106053439) |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc640712 |
similar to cullin 4A |
75.59(n) |
|
394002 BC054607.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
cul-43 |
ubiquitin-protein ligase |
68(a) |
|
44B1 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
cul-43 |
Expression: all stages |
33(a) |
|
II(7302044-7305464) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
CUL46 |
cullin4 |
53(a) |
1 → many |
5(18731418-18736810) |
rice
(Oryza sativa) |
Liliopsida |
-- |
cullin, putative, expressed |
49(a) |
1 → many |
3(32664920-32671888) |
ENSEMBL Gene Tree for CUL4A (if available)
TreeFam Gene Tree for CUL4A (if available) |
Paralogs
for CUL4A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CUL4A gene
- CUL12 CUL32 CUL22 CUL4B2 CUL52
4 SIMAP similar genes for CUL4A using alignment to 1 protein entry: CUL4A_HUMAN:CUL4B CUL3 CUL1 CUL2
CUL4A for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CUL4A
PGOHUM00000245668
|
Genomic Variants
for CUL4A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CUL4A (113862552 - 113919399 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for CUL4A
9 CNVs: 87072 87076 87071 87073 87074 66567 87070 87075 76522 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CUL4A |
|
Disorders
/ Diseases
for CUL4A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CUL4A for disorders About GeneDecksing
OMIM gene information: 603137
OMIM disorders: --
9  diseases for CUL4A: About MalaCardsxeroderma pigmentosum cockayne syndrome lung adenocarcinoma hepatocellular carcinoma
adenocarcinoma breast cancer immunodeficiency carcinoma
malaria
1 disease from the University of Copenhagen DISEASES database for CUL4A:Xeroderma pigmentosum 2 Novoseek disease relationships for CUL4A gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| xeroderma pigmentosum |
79.9 |
1 |
11564859 (1) |
| tumors |
0 |
1 |
12878869 (1) |
Human Genome Epidemiology (HuGE) Navigator: CUL4A (1 document)
Export disorders for CUL4A gene to outside databases
|
Publications
for CUL4A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CUL4A gene, integrated from 9 sources (see all 167):
(articles sorted by number of sources associating them with CUL4A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. (PubMed id 8681378)1, 2, 3 Kipreos E.T.... Hedgecock E.M. (1996)
- Cul4A and DDB1 associate with Skp2 to target p27Kip1 for proteolysis involving the COP9 signalosome. (PubMed id 16537899)1, 2, 9 Bondar T....Raychaudhuri P. (2006)
- DDB2, the xeroderma pigmentosum group E gene product, is directly ubiquitylated by Cullin 4A-based ubiquitin ligase complex. (PubMed id 15811626)1, 2, 9 Matsuda N.... Tanaka K. (2005)
- Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. (PubMed id 15448697)1, 2, 9 Hu J.... Xiong Y. (2004)
- Covalent modification of all members of human cullin family proteins by NEDD8. (PubMed id 10597293)1, 2, 9 Hori T.... Tanaka K. (1999)
- A new NEDD8-ligating system for cullin-4A. (PubMed id 9694792)1, 2, 9 Osaka F.... Kato S. (1998)
- Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. (PubMed id 14739464)1, 2, 9 Wertz I.E.... Dixit V.M. (2004)
- The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. (PubMed id 12732143)1, 2, 9 Groisman R.... Nakatani Y. (2003)
- A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases. (PubMed id 20190741)1, 2 Gastaldello S.... Masucci M.G. (2010)
- Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. (PubMed id 16678110)1, 2 Wang H.... Zhang Y. (2006)
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External Searches for CUL4A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing CUL4A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing CUL4A gene
(According to HUGE)
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Specialized Databases showing CUL4A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for CUL4A gene:
Search GeneIP for patents involving CUL4A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CUL4A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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