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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CUL4A Gene

protein-coding   GIFtS: 62
GCID: GC13P113863

Cullin 4A

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cullin 4A1 2
CUL-4A2 3
cullin-4A2

External Ids:    HGNC: 25541   Entrez Gene: 84512   Ensembl: ENSG000001398427   OMIM: 6031375   UniProtKB: Q136193   

Export aliases for CUL4A gene to outside databases

Previous GC identifers: GC13P112473 GC13P108500 GC13P112949 GC13P111811 GC13P112911 GC13P094301


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CUL4A Gene:
CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response
proteins (Liu et al., 2009 (PubMed 19481525)).(supplied by OMIM, Oct 2009)

GeneCards Summary for CUL4A Gene: 
CUL4A (cullin 4A) is a protein-coding gene. Diseases associated with CUL4A include glomuvenous malformation, and xeroderma pigmentosum, and among its related super-pathways are Global Genomic NER (GG-NER) and Antigen processing: Ubiquitination & Proteasome degradation. GO annotations related to this gene include protein binding and ubiquitin protein ligase binding. An important paralog of this gene is CUL1.

UniProtKB/Swiss-Prot: CUL4A_HUMAN, Q13619
Function: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the
ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to
catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein
ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the
association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3
ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs
ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. In association with RBX1, DDB1 and DDB2 is
required for histone H3 and histone H4 ubiquitination in response to ultraviolet and may be important for
subsequent DNA repair. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent
ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association
with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of
HOXA9

Gene Wiki entry for CUL4A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_027140.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CUL4A gene promoter:
         CREB   HEN1   Nkx6-1   deltaCREB   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCUL4A promoter sequence
   Search SABiosciences Chromatin IP Primers for CUL4A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CUL4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

CUL4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CUL4A gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P113863:  view genomic region     (about GC identifiers)

Start:
113,862,552 bp from pter      End:
113,919,399 bp from pter
Size:
56,848 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CUL4A_HUMAN, Q13619 (See protein sequence)
Recommended Name: Cullin-4A  
Size: 759 amino acids; 87680 Da
Subunit: Component of multiple DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes that seem to consist of
DDB1, CUL4A or CUL4B, RBX1 and a variable substrate recognition component which seems to belong to a protein
family described as DCAF (Ddb1- and Cul4-associated factor) or CDW (CUL4-DDB1-associated WD40-repeat) proteins.
Component of the CSA complex (DCX(ERCC8) complex) containing ERCC8, RBX1, DDB1 and CUL4A; the CSA complex
interacts with RNA polymerase II; upon UV irradiation it interacts with the COP9 signalosome and preferentially
with the hyperphosphorylated form of RNA polymerase II. Component of the DCX(DET1-COP1) complex with the
substrate recognition component DET1 and COP1. Component of the DCX(DDB2) complex with the substrate recognition
component DDB2. Component of the DCX(DTL) complex with the putative substrate recognition component DTL.
Interacts with DDB1, RBX1, RNF7, CTD1, TIP120A/CAND1, SKP2, CDKN1B, MDM2, TP53 and HOXA9. Interacts with DDB2;
the interactions with DDB2 and CAND1 are mutually exclusive. Interacts with VPRBP, DTL, DDA1, DCAF6, DCAF4,
DCAF16, DCAF17, DET1, WDTC1, DCAF5, DCAF11, WDR24A, RFWD2, PAFAH1B1, ERCC8, GRWD1, FBXW5, RBBP7, GNB2, WSB1,
WSB2, NUP43, PWP1, FBXW8, ATG16L1, KATNB1, RBBP4, RBBP5 and DCAF8. May interact with WDR26, WDR51B, SNRNP40,
WDR61, WDR76, WDR5. Can self-associate. Interacts with Epstein-Barr virus BPLF1
2 PDB 3D structures from and Proteopedia for CUL4A:
2HYE (3D)        4A0K (3D)    
Secondary accessions: A2A2W2 O75834 Q589T6 Q5TC62 Q6UP08 Q9UP17
Alternative splicing: 2 isoforms:  Q13619-1   Q13619-2   

Explore the universe of human proteins at neXtProt for CUL4A: NX_Q13619

Explore proteomics data for CUL4A at MOPED 

Post-translational modifications:

  • UniProtKB: Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex (By similarity). Deneddylated
    by Epstein-Barr virus BPLF1 leading to a S-phase-like environment that is required for efficient replication of
    the viral genome
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13619

  • CUL4A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CUL4A Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001008895.1  NP_001265442.1  NP_001265443.1  NP_003580.1  

    ENSEMBL proteins: 
     ENSP00000322132   ENSP00000364589   ENSP00000364590   ENSP00000389118  

    Human Recombinant Protein Products for CUL4A: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CUL4A 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031461cullin-RING ubiquitin ligase complex ----
    GO:0031464Cul4A-RING ubiquitin ligase complex IDA12732143
    GO:0080008Cul4-RING ubiquitin ligase complex IDA18381890

    CUL4A for ontologies           About GeneDecksing



    CUL4A Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR016159 Cullin_repeat-like_dom
     IPR019559 Cullin_neddylation_domain
     IPR016157 Cullin_CS
     IPR001373 Cullin_N
     IPR011991 WHTH_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q13619

    ProtoNet protein and cluster: Q13619

    1 Blocks protein domain: IPB001373 Cullin

    UniProtKB/Swiss-Prot: CUL4A_HUMAN, Q13619
    Similarity: Belongs to the cullin family


    CUL4A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CUL4A_HUMAN, Q13619
    Function: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the
    ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to
    catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein
    ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the
    association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3
    ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs
    ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. In association with RBX1, DDB1 and DDB2 is
    required for histone H3 and histone H4 ubiquitination in response to ultraviolet and may be important for
    subsequent DNA repair. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent
    ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association
    with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of
    HOXA9

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12504025
    GO:0031625ubiquitin protein ligase binding IEA--
         
    CUL4A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CUL4A:
     Increased cell death in HCT116 

         11 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Cul4a):
     cellular  digestive/alimentary  endocrine/exocrine gland  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  reproductive system 
     tumorigenesis 

    CUL4A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CUL4A: Cul4atm1.2Pra Cul4atm1.2Pz Cul4a/Pcid2Cul4a/tm1Ktc

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CUL4A 
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    SwitchGear 3'UTR luciferase reporter plasmidCUL4A 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUL4A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CUL4A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Global Genomic NER (GG-NER)
    Nucleotide excision repair0.70
    2Antigen processing: Ubiquitination & Proteasome degradation
    Ubiquitin mediated proteolysis0.36
    3Protein Stability
    Protein Stability

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CUL4A
        Protein Stability


    2         Kegg Pathways  (Kegg details for CUL4A):
        Nucleotide excision repair
    Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: CUL4A_HUMAN, Q13619
    Pathway: Protein modification; protein ubiquitination


    CUL4A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CUL4A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/218 Interacting proteins for CUL4A (Q136191, 2, 3 ENSP000003645894) via UniProtKB, MINT, STRING, and/or I2D (see all 218)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4LP628053, ENSP000003482584I2D: score=1 STRING: ENSP00000348258
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS8681378
    GO:0006281DNA repair IEA--
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0007050cell cycle arrest TAS8681378
    GO:0007346regulation of mitotic cell cycle IEA--

    CUL4A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CUL4A

    Search CenterWatch for drugs/clinical trials and news about CUL4A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CUL4A gene (4 alternative transcripts): 
    NM_001008895.2  NM_001278513.1  NM_001278514.1  NM_003589.2  

    Unigene Cluster for CUL4A:

    Cullin 4A
    Hs.339735  [show with all ESTs]
    Unigene Representative Sequence: NM_001008895
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326335(uc010agu.3 uc010tjz.2) ENST00000375440 ENST00000488558
    ENST00000474116 ENST00000494985 ENST00000463426 ENST00000498562 ENST00000470067
    ENST00000472083 ENST00000375441 ENST00000451881(uc021rmu.1 uc021rmv.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate CUL4A (see all 28):
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    Additional mRNA sequence: 

    AB012193.1 AB178950.1 AF077188.1 AK023430.1 AK126278.1 AK296700.1 AK314835.1 AL833355.1 
    AY365124.1 BC008308.1 BC015166.1 U58090.1 

    24/29 DOTS entries (see all 29):

    DT.97826298  DT.95133634  DT.92000929  DT.97783600  DT.100828097  DT.100804102  DT.413424  DT.87016277 
    DT.106271  DT.100828091  DT.97794285  DT.101985114  DT.40208642  DT.95133622  DT.101975926  DT.65286724 
    DT.92063363  DT.100828098  DT.91751229  DT.100828092  DT.100689792  DT.100735373  DT.101971879  DT.120776861 

    24/424 AceView cDNA sequences (see all 424):

    BU686345 BQ006729 AI222827 BG286909 AB012193 CB241305 BX095135 CB105171 
    BI259757 AA319020 AA361397 AI198557 AA633204 CA445237 AA744468 AW194088 
    BC008308 CR616294 AA150317 AL526514 CB132281 AA832183 BG723380 AI371296 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for CUL4A (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a ·
    SP1:                          -                 -           -     -                       -     -     -                             -                           
    SP2:                                            -           -     -                       -     -                                   -                           
    SP3:                                      -     -           -     -                       -     -     -                             -                           
    SP4:        -     -     -     -                 -           -     -                       -     -     -                                                         
    SP5:              -     -     -                 -           -     -                                                                                             

    ExUns: 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b · 26c
    SP1:                                                                  
    SP2:                                                                  
    SP3:                                                                  
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for CUL4A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CUL4A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATATGTGGTC
    CUL4A Expression
    About this image


    See CUL4A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CUL4A

    SOURCE GeneReport for Unigene cluster: Hs.339735
        SABiosciences Expression via Pathway-Focused PCR Arrays including CUL4A: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CUL4A gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cul4a1 , 5 cullin 4A1, 5 86.21(n)1
    95.13(a)1
      8 (5.73 cM)5
    993751  NM_146207.21  NP_666319.21 
     131056215 
    chicken
    (Gallus gallus)
    Aves CUL4A1 cullin 4A 80.85(n)
    91.3(a)
      418744  XM_003640529.1  XP_003640577.1 
    lizard
    (Anolis carolinensis)
    Reptilia CUL4A6
    Uncharacterized protein
    80(a)
    1 ↔ 1
    3(106014173-106053439)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc640712 similar to cullin 4A 75.59(n)   394002  BC054607.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cul-43 ubiquitin-protein ligase 68(a)   44B1   --
    worm
    (Caenorhabditis elegans)
    Secernentea cul-43 Expression: all stages 33(a)   II(7302044-7305464)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC536
    Cullin, structural protein of SCF complexes (which...
    20(a)
    1 → many
    IV(224304-226751)
    soybean
    (Glycine max)
    eudicotyledons CA783962.12   -- 72.05(n)    CA783962.1 


    ENSEMBL Gene Tree for CUL4A (if available)
    TreeFam Gene Tree for CUL4A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CUL4A gene
    CUL12  CUL32  CUL4B2  CUL22  CUL52  
    4 SIMAP similar genes for CUL4A using alignment to 1 protein entry:     CUL4A_HUMAN:
    CUL4B    CUL3    CUL1    CUL2

    CUL4A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CUL4A
    PGOHUM00000245668


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1353 SNPs in CUL4A are shown (see all 1353)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1863931571,2
    --113865073(+) ATGTGC/TCATAC 2 -- int10--------
    rs38414251,2
    C--113865114(-) AAAAA-/AAGTTTT 2 -- int10--------
    rs669285051,2
    C--113865114(+) AAAAC-/TTTTTTT 2 -- int10--------
    rs786471851,2
    C,F--113865153(+) AAATTA/TTAAAA 2 -- int11Minor allele frequency- T:0.03WA 118
    rs756934471,2
    C,F--113865163(+) AAATAC/TAAAAA 2 -- int11Minor allele frequency- T:0.03WA 118
    rs735810191,2
    C,F--113865306(+) ATATAA/GTGTGC 2 -- int12Minor allele frequency- G:0.06WA 120
    rs79846651,2
    C,F,A,H--113865336(+) gatgcA/Gtgcag 2 -- int115Minor allele frequency- G:0.04NS EA NA WA 1944
    rs786278291,2
    --113865475(+) GTCCCC/GCATTT 2 -- int10--------
    rs1504211181,2
    --113865607(+) TGTGAC/TTGTAA 2 -- int10--------
    rs726652171,2
    C,F--113865695(+) TGGGGT/GTTTTT 2 -- int11Minor allele frequency- G:0.01NA 120

    HapMap Linkage Disequilibrium report for CUL4A (113862552 - 113919399 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/18 variations for CUL4A (see all 18):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2748271CNV Deletion23290073
    esv2748267CNV Deletion23290073
    esv2748268CNV Deletion23290073
    esv2748269CNV Deletion23290073
    esv2748266CNV Deletion23290073
    esv2748270CNV Deletion23290073
    nsv1194CNV Insertion18451855
    esv1654591CNV Insertion17803354
    esv1574408CNV Insertion17803354
    nsv509520CNV Insertion20534489

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603137    OMIM disorders: --

    14 diseases for CUL4A:    About MalaCards
    glomuvenous malformation    xeroderma pigmentosum    malignant pleural mesothelioma    lung adenocarcinoma
    pheochromocytoma    adenocarcinoma    hepatitis b    hepatocellular carcinoma
    hypoxia    gastric cancer    prostate cancer    breast cancer
    hepatitis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for CUL4A:
    Xeroderma pigmentosum

    CUL4A for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for CUL4A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    xeroderma pigmentosum 79.9 1 11564859 (1)
    tumors 0 1 12878869 (1)

    Genetic Association Database (GAD): CUL4A
    Human Genome Epidemiology (HuGE) Navigator: CUL4A (1 document)

    Export disorders for CUL4A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CUL4A gene, integrated from 9 sources (see all 176):
    (articles sorted by number of sources associating them with CUL4A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. (PubMed id 8681378)1, 2, 3 Kipreos E.T.... Hedgecock E.M. (1996)
    2. Cul4A and DDB1 associate with Skp2 to target p27Kip1 for proteolysis involving the COP9 signalosome. (PubMed id 16537899)1, 2, 9 Bondar T....Raychaudhuri P. (2006)
    3. DDB2, the xeroderma pigmentosum group E gene product, is directly ubiquitylated by Cullin 4A-based ubiquitin ligase complex. (PubMed id 15811626)1, 2, 9 Matsuda N.... Tanaka K. (2005)
    4. Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. (PubMed id 15448697)1, 2, 9 Hu J.... Xiong Y. (2004)
    5. Covalent modification of all members of human cullin family proteins by NEDD8. (PubMed id 10597293)1, 2, 9 Hori T.... Tanaka K. (1999)
    6. A new NEDD8-ligating system for cullin-4A. (PubMed id 9694792)1, 2, 9 Osaka F.... Kato S. (1998)
    7. Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. (PubMed id 14739464)1, 2, 9 Wertz I.E.... Dixit V.M. (2004)
    8. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. (PubMed id 12732143)1, 2, 9 Groisman R.... Nakatani Y. (2003)
    9. A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases. (PubMed id 20190741)1, 2 Gastaldello S.... Masucci M.G. (2010)
    10. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8451 HGNC: 2554 AceView: CUL4A Ensembl:ENSG00000139842 euGenes: HUgn8451
    ECgene: CUL4A Kegg: 8451 H-InvDB: CUL4A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CUL4A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CUL4A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CUL4A gene:
    Search GeneIP for patents involving CUL4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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