CUL3 Gene
protein-coding GIFtS: 66
GCID: GC02M225298
|
|
cullin 3
| |
Aliases
for CUL3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cullin 31 2 | | CUL-32 3 | | PHA2E2 | | Cullin-31 | | KIAA06173 |
Export aliases for CUL3 gene to outside databasesPrevious GC identifers: GC02M223357 GC02M224055 GC02M225537 GC02M225160 GC02M225043 GC02M217186 |
Summaries
for CUL3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CUL3:
This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in thepolyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffoldprotein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in lateendosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively splicedtranscript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Mar 2012)
UniProtKB/Swiss-Prot: CUL3_HUMAN, Q13618Function: Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes whichmediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein maycontribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and isinhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functionalspecificity of the BCR complex depends on the BTB domain-containing protein as the susbstrate recognition component.BCR(KLHL42) is involved in ubiquitination of KATNA1. BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, H2AFY andDAXX, and probably GLI2 or GLI3. BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes andthereby coordinates faithful mitotic progression and completion of cytokinesis. BCR(KLHL12) is involved in ER-Golgitransport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required forembryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B).BCR(KLHL3) acts as a regulator of ion transport in the distal nephron; possibly by mediating ubiquitination ofSLC12A3/NCC. Involved in ubiquitination of cyclin E and of cyclin D1 (in vitro) thus involved in regulation of G1/Stransition. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41
Gene Wiki entry for CUL3
|
Genomic Views
for CUL3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CUL3 gene promoter:
E2F-3a E2F-4 E2F-5 Egr-1 E2F-2 RelA PPAR-gamma1 E2F E2F-1 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CUL3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CUL3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q36.2 Ensembl cytogenetic band: 2q36.2 HGNC cytogenetic band: 2q36.2CUL3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M225298: view genomic region
(about GC identifiers)
Start:
|
225,334,867 bp from pter |
End:
|
225,450,110 bp from pter |
Size:
|
115,244 bases |
Orientation:
|
minus strand |
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Proteins
for CUL3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CUL3_HUMAN, Q13618 (See
protein sequence)Recommended Name: Cullin-3 Size: 768 amino acids; 88930 Da
Subunit: Forms neddylation-dependent homodimers. Component of multiple BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligasecomplexes formed of CUL3, RBX1 and a variable BTB domain-containing protein acting as both, adapter to cullin andsubstrate recognition subunit. The BCR complex may be active as a heterodimeric complex, in which NEDD8, covalentlyattached to one CUL3 molecule, binds to the C-terminus of a second CUL3 molecule. Interacts with RBX1, RNF7, CYCE andTIP120A/CAND1. Part of the BCR(SPOP) containing SPOP. Part of the probable BCR(KLHL9-KLHL13) complex with BTB domainproteins KLHL9 and KLHL13. Part of the BCR(KLHL41) complex containing KLHL41. Component of the BCR(KLHL12) E3ubiquitin ligase complex, at least composed of CUL3 and KLHL12 and RBX1. Component of the BCR(KLHL3) E3 ubiquitinligase complex, at least composed of CUL3 and KLHL3 and RBX1 (Probable). Part of the BCR(ENC1) complex containingENC1. Part of a complex consisting of BMI1/PCGF4, CUL3 and SPOP. Part of a complex consisting of H2AFY, CUL3 and SPOP.Component of the BCR(KLHL42) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL42. Interacts with KLHL42(via the BTB domain). Interacts with KATNA1; the interaction is enhanced by KLHL42. Interacts with KCTD5, KLHL9,KLHL13, GAN, ZBTB16, KLHL21, KLHL3, KLHL15, KLHL20, KLHL36, GMCL1P1, BTBD1. Part of a complex that contains CUL3, RBX1and GAN. Interacts (via BTB domain) with KLHL17; the interaction regulates surface GRIK2 expression. Interacts withKCTD7. Part of the BCR(GAN) complex containing GAN. Part of the BCR(KEAP1) complex containing KEAP1
Subcellular location: Nucleus. Golgi apparatus
Sequence caution: Sequence=AAC28621.1; Type=Frameshift; Positions=452; Sequence=AAC36682.1; Type=Frameshift;Positions=159, 179; Sequence=BAA31592.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from  and Proteopedia  for CUL3:4AP2 (3D)
4APF (3D)
4EOZ (3D)
Secondary accessions: A8K536 B8ZZC3 O75415 Q569L3 Q9UBI8 Q9UET7Alternative splicing: 3 isoforms: Q13618-1 Q13618-2 Q13618-3 Explore the universe of human proteins at neXtProt for CUL3: NX_Q13618
Post-translational modifications:
Neddylated. Attachment of NEDD8 is required for the E3 ubiquitin-protein ligase activity of the BCR complex.Deneddylated via its interaction with the COP9 signalosome (CSN) complex1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13618
CUL3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001244126.1 NP_001244127.1 NP_003581.1
ENSEMBL proteins: ENSP00000264414 ENSP00000400558 ENSP00000387200 ENSP00000386525 ENSP00000410575 ENSP00000400935 ENSP00000343601 Reactome Protein details: Q13618
Human Recombinant Protein Products for CUL3:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
CUL3 for ontologies About GeneDecksing
CUL3 Antibody Products:
Assay Products for CUL3: |
Protein
Domains /
Families
for CUL3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CUL3 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q13618ProtoNet protein and cluster: Q13618 1 Blocks protein family: IPB001373 Cullin
UniProtKB/Swiss-Prot: CUL3_HUMAN, Q13618Similarity: Belongs to the cullin family |
Function
for CUL3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CUL3_HUMAN, Q13618Function: Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes whichmediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein maycontribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and isinhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functionalspecificity of the BCR complex depends on the BTB domain-containing protein as the susbstrate recognition component.BCR(KLHL42) is involved in ubiquitination of KATNA1. BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, H2AFY andDAXX, and probably GLI2 or GLI3. BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes andthereby coordinates faithful mitotic progression and completion of cytokinesis. BCR(KLHL12) is involved in ER-Golgitransport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required forembryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B).BCR(KLHL3) acts as a regulator of ion transport in the distal nephron; possibly by mediating ubiquitination ofSLC12A3/NCC. Involved in ubiquitination of cyclin E and of cyclin D1 (in vitro) thus involved in regulation of G1/Stransition. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41 Genatlas biochemistry entry for CUL3:cullin 3,salicylate suppressible gene,89kDa,C elegans cullin/Cdc53 (CUL) family member,likely involved in cellproliferation control
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
CUL3 for ontologies About GeneDecksing
Phenotypes:
4 GenomeRNAi human phenotypes for CUL3:
5 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Cul3):
CUL3 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Cul3tm1Jro for CUL3
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CUL3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CUL3 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CUL3 (NM_003590) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CUL3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUL3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUL3 |
|
Pathways & Interactions
for CUL3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Antigen processing: Ubiquitination & Proteasome degradation | | | 2 | Immune System | | | 3 | Protein Stability | | | 4 | Aurora B signaling | | | 5 | Canonical Wnt signaling pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for CUL3
3  BioSystems Pathways for CUL3
5 
Reactome Pathways for CUL3
1 
Kegg Pathway (Kegg details for CUL3):
UniProtKB/Swiss-Prot: CUL3_HUMAN, Q13618Pathway: Protein modification; protein ubiquitination
CUL3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CUL3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/243 Interacting proteins for CUL3 (Q136181, 2, 3 ENSP000002644144) via UniProtKB, MINT, STRING, and/or I2D (see all 243)
About this table
Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25): About this table
CUL3 for ontologies About GeneDecksing
|
Drugs & Compounds
for CUL3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CUL3 for compounds About GeneDecksing
 Browse Tocris compounds for CUL3
1 Novoseek chemical compound relationship for CUL3 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| lysine |
27.5 |
1 |
15572695 (1) |
Search CenterWatch for drugs/clinical trials and news about CUL3
|
Transcripts
for CUL3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CUL3 gene (3 alternative transcripts): NM_001257197.1 NM_001257198.1 NM_003590.4 Unigene Cluster for CUL3: Cullin 3 Hs.372286 [show with all ESTs]Unigene Representative Sequence: NM_00359015 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000264414(uc010fwy.1 uc002vny.2) ENST00000497715 ENST00000454323
ENST00000409096 ENST00000409777 ENST00000451538 ENST00000536702 ENST00000487558
ENST00000481135 ENST00000484081 ENST00000541548 ENST00000432260 ENST00000436172
ENST00000546102 ENST00000344951(uc010zls.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CUL3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CUL3 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CUL3 (NM_003590) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CUL3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUL3 |
Additional cDNA sequence: AB014517.2 AF052147.1 AF062537.1 AF064087.1 AK098531.1 AK291151.1 AK299644.1 AK308496.1 AY007151.1 AY337761.1 BC031844.1 BC039598.1 BC092409.1 U58089.1 18 DOTS entries: DT.455114 DT.92409519 DT.100029181 DT.91722547 DT.120999387 DT.91757974 DT.95164412 DT.99928171 DT.100728655 DT.120999360 DT.120999410 DT.86851392 DT.91757963 DT.91757978 DT.91830938 DT.97800924 DT.102832628 DT.95204178 24/367 AceView cDNA sequences (see all 367): AA449074 R38742 BU687479 BQ687143 BX956353 AA133493 BE464384 AA380036 CR603582 BM855146 BQ688156 Z21352 CB306448 BU162882 CB157780 NM_003590 BF198018 BC031844 AA489370 BP340205 BM670800 AI761926 BF431840 AA282431
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CUL3 (see all 10) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | - | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | · | 21c | ^ | 22a | · | 22b | · | 22c |
|---|
|
| SP1: | | | - | | - | | | | - | | | | | | | | | | | | |
| SP2: | | | - | | - | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CUL3
|
Expression
for CUL3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CUL3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTAGACCA
About this image
See CUL3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CUL3
SOURCE GeneReport for Unigene cluster: Hs.372286
UniProtKB/Swiss-Prot: CUL3_HUMAN, Q13618Tissue specificity: Widely expressed
SABiosciences Expression via Pathway-Focused PCR Arrays including CUL3:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CUL3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CUL3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CUL3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CUL3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUL3 |
Orthologs
for CUL3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CUL3 gene from 8/34 species (see all 34) About this table
ENSEMBL Gene Tree for CUL3 (if available)
TreeFam Gene Tree for CUL3 (if available) |
Paralogs
for CUL3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CUL3 gene
- CUL12 CUL22 CUL4B2 CUL4A2 CUL52
4 SIMAP similar genes for CUL3 using alignment to 6 protein entries: CUL3_HUMAN (see all proteins):CUL4B CUL4A CUL1 CUL2
CUL3 for paralogs About GeneDecksing
|
Genomic Variants
for CUL3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CUL3 (225334867 - 225450110 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CUL3
2 CNVs: 98149 98150
Human Gene Mutation Database (HGMD): CUL3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CUL3 |
|
Disorders
/ Diseases
for CUL3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CUL3 for disorders About GeneDecksing
OMIM gene information: 603136
OMIM disorders: --
UniProtKB/Swiss-Prot: CUL3_HUMAN, Q13618
Defects in CUL3 are the cause of Pseudohypoaldosteronism type 2E (PHA2E) [MIM:614496]. An autosomal dominantdisorder characterized by severe hypertension, hyperkalemia, hyperchloremia, hyperchloremic metabolic acidosis, andcorrection of physiologic abnormalities by thiazide diuretics
14  diseases for CUL3: About MalaCardschronic obstructive pulmonary disease pseudohypoaldosteronism monkeypox retinitis pigmentosa
wilms tumor pulmonary disease retinitis breast cancer
malaria neuronitis hypertension prostate cancer, progression of
prostate cancer prostatitis
Human Genome Epidemiology (HuGE) Navigator: CUL3 (2 documents)
Export disorders for CUL3 gene to outside databases
|
Publications
for CUL3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CUL3 gene, integrated from 9 sources (see all 152):
(articles sorted by number of sources associating them with CUL3) | |  | Utopia: connect your pdf to the dynamic
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- The Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimer. (PubMed id 17192413)1, 2, 3 Wimuttisuk W. and Singer J.D. (2007)
- cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. (PubMed id 8681378)1, 2, 3 Kipreos E.T.... Hedgecock E.M. (1996)
- Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells. (PubMed id 10500095)1, 2, 9 Singer J.D.... Roberts J.M. (1999)
- A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells. (PubMed id 17543862)1, 2, 9 Sumara I....Peter M. (2007)
- BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase. (PubMed id 16524876)1, 2, 9 Kwon J.E.... Chung C.H. (2006)
- Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway. (PubMed id 15983046)1, 2, 9 Zhang D.D.... Hannink M. (2005)
- Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities. (PubMed id 22266938)1, 2 Boyden L.M.... Lifton R.P. (2012)
- A homozygous mutation in KCTD7 links neuronal ceroid l ipofuscinosis to the ubiquitin-proteasome system. (PubMed id 22748208)1, 2 Staropoli J.F....Cotman S.L. (2012)
- The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells. (PubMed id 19261606)1, 2 Cummings C.M....Singer J.D. (2009)
- KCTD5, a putative substrate adaptor for cullin3 ubiquitin ligases. (PubMed id 18573101)1, 2 Bayon Y.... Alonso A. (2008)
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External Searches for CUL3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing CUL3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing CUL3 gene
(According to HUGE)
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Specialized Databases showing CUL3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for CUL3 gene:
Search GeneIP for patents involving CUL3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CUL3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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