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Aliases for CUL2 Gene

Aliases for CUL2 Gene

  • Cullin 2 2 3 5
  • CUL-2 3 4
  • Testis Secretory Sperm-Binding Protein Li 238E 3

External Ids for CUL2 Gene

Previous GeneCards Identifiers for CUL2 Gene

  • GC10M035449
  • GC10M035302
  • GC10M035338

Summaries for CUL2 Gene

GeneCards Summary for CUL2 Gene

CUL2 (Cullin 2) is a Protein Coding gene. Diseases associated with CUL2 include renal cell carcinoma and hypoxia. Among its related pathways are Immune System and Cellular Senescence. GO annotations related to this gene include ubiquitin protein ligase binding and protein complex binding. An important paralog of this gene is CUL1.

UniProtKB/Swiss-Prot for CUL2 Gene

  • Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).

Gene Wiki entry for CUL2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUL2 Gene

Genomics for CUL2 Gene

Regulatory Elements for CUL2 Gene

Transcription factor binding sites by QIAGEN in the CUL2 gene promoter:

Genomic Location for CUL2 Gene

Chromosome:
10
Start:
35,008,551 bp from pter
End:
35,126,899 bp from pter
Size:
118,349 bases
Orientation:
Minus strand

Genomic View for CUL2 Gene

Genes around CUL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CUL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CUL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUL2 Gene

Proteins for CUL2 Gene

  • Protein details for CUL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13617-CUL2_HUMAN
    Recommended name:
    Cullin-2
    Protein Accession:
    Q13617
    Secondary Accessions:
    • B3KT95
    • B7Z6K8
    • D3DRY6
    • G3V1S2
    • O00200
    • Q5T2B6
    • Q9UNF9

    Protein attributes for CUL2 Gene

    Size:
    745 amino acids
    Molecular mass:
    86983 Da
    Quaternary structure:
    • Component of multiple ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes formed of CUL2, Elongin BC (TCEB1 and TCEB2), RBX1 and a variable substrate-specific adapter. Component of the ECS(VHL) or CBC(VHL) complex containing VHL. Component of the ECS(MED8) complex with the probable substrate recognition component MED8. Component of the ECS(LRR1) complex with the probable substrate recognition component LRR1. Component of a probable ECS E3 ubiquitin-protein ligase complex containing CUL2, RBX1, TCEB1, TCEB2 and FEM1B. Part of an E3 ubiquitin-protein ligase complex including ZYG11B, CUL2 and Elongin BC. Part of an E3 ubiquitin-protein ligase complex including ZYG11BL, CUL2 and Elongin BC. Interacts with RBX1, RNF7, FEM1B and TIP120A/CAND1. Interacts with COPS2, and MED8. Interacts with human respiratory syncytial virus (HRSV) protein NS1. Found in a complex composed of LIMD1, VHL, EGLN1/PHD2, TCEB2 and CUL2. Interacts with KLHDC10; which may be an E3 ubiquitin ligase complex substrate recognition component.

    Three dimensional structures from OCA and Proteopedia for CUL2 Gene

    Alternative splice isoforms for CUL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CUL2 Gene

Proteomics data for CUL2 Gene at MOPED

Post-translational modifications for CUL2 Gene

  • CBC(VHL) complex formation seems to promote neddylation. Deneddylated via its interaction with the COP9 signalosome (CSN) complex (By similarity).
  • Ubiquitination at Lys 16
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CUL2 Gene

Domains & Families for CUL2 Gene

Gene Families for CUL2 Gene

Suggested Antigen Peptide Sequences for CUL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13617

UniProtKB/Swiss-Prot:

CUL2_HUMAN :
  • Belongs to the cullin family.
Family:
  • Belongs to the cullin family.
genes like me logo Genes that share domains with CUL2: view

Function for CUL2 Gene

Molecular function for CUL2 Gene

GENATLAS Biochemistry:
cullin 2,complexing with VHL/elongin B and C to form an ubiquitin-ligase complex referred to VCB-CUL2(see VHL),putatively targetting certain proteins for degradation,not a major renal cell carcinoma,tumor suppressor gene,but maybe involved in other carcinomas,see TSG10
UniProtKB/Swiss-Prot Function:
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
genes like me logo Genes that share phenotypes with CUL2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CUL2 Gene

Localization for CUL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CUL2 Gene COMPARTMENTS Subcellular localization image for CUL2 gene
Compartment Confidence
cytosol 5
nucleus 5
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CUL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA,TAS --
genes like me logo Genes that share ontologies with CUL2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CUL2 Gene

Pathways & Interactions for CUL2 Gene

genes like me logo Genes that share pathways with CUL2: view

UniProtKB/Swiss-Prot Q13617-CUL2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for CUL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
GO:0071456 cellular response to hypoxia TAS --
GO:0097193 intrinsic apoptotic signaling pathway TAS 8681378
genes like me logo Genes that share ontologies with CUL2: view

No data available for SIGNOR curated interactions for CUL2 Gene

Drugs & Compounds for CUL2 Gene

(1) Drugs for CUL2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CUL2: view

Transcripts for CUL2 Gene

Unigene Clusters for CUL2 Gene

Cullin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CUL2 Gene

No ASD Table

Relevant External Links for CUL2 Gene

GeneLoc Exon Structure for
CUL2
ECgene alternative splicing isoforms for
CUL2

Expression for CUL2 Gene

mRNA expression in normal human tissues for CUL2 Gene

Protein differential expression in normal tissues from HIPED for CUL2 Gene

This gene is overexpressed in Lymph node (12.6) and Peripheral blood mononuclear cells (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CUL2 Gene



SOURCE GeneReport for Unigene cluster for CUL2 Gene Hs.82919

genes like me logo Genes that share expression patterns with CUL2: view

Protein tissue co-expression partners for CUL2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CUL2 Gene

Orthologs for CUL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CUL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CUL2 35
  • 94.14 (n)
  • 99.6 (a)
CUL2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CUL2 35
  • 94.99 (n)
  • 99.46 (a)
CUL2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cul2 35
  • 91.36 (n)
  • 97.32 (a)
Cul2 16
Cul2 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CUL2 35
  • 99.69 (n)
  • 99.87 (a)
CUL2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cul2 35
  • 90.62 (n)
  • 97.52 (a)
oppossum
(Monodelphis domestica)
Mammalia CUL2 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CUL2 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves CUL2 35
  • 87.81 (n)
  • 96.66 (a)
CUL2 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CUL2 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cul2 35
  • 83.8 (n)
  • 93.83 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC69167 35
zebrafish
(Danio rerio)
Actinopterygii cul2 35
  • 76.87 (n)
  • 92.21 (a)
wufj48a06 35
cul2 36
  • 90 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.763 35
fruit fly
(Drosophila melanogaster)
Insecta cul-2 37
  • 50 (a)
Cul-2 35
  • 54.2 (n)
  • 51.9 (a)
Cul-2 36
  • 50 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003605 35
  • 55.01 (n)
  • 52.03 (a)
worm
(Caenorhabditis elegans)
Secernentea cul-2 35
  • 50.65 (n)
  • 45.21 (a)
cul-2 36
  • 39 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC53 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2270 36
  • 42 (a)
OneToOne
Species with no ortholog for CUL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CUL2 Gene

ENSEMBL:
Gene Tree for CUL2 (if available)
TreeFam:
Gene Tree for CUL2 (if available)

Paralogs for CUL2 Gene

Paralogs for CUL2 Gene

(5) SIMAP similar genes for CUL2 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for CUL2 Gene

genes like me logo Genes that share paralogs with CUL2: view

Variants for CUL2 Gene

Sequence variations from dbSNP and Humsavar for CUL2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1131503 - 35,054,531(-) TCTCA(A/G)CACCC reference, missense
rs12830 -- 35,013,777(-) TCTTC(A/G)TTTTC reference, synonymous-codon
rs15460 -- 35,009,984(-) TGTAT(C/T)TTAAA utr-variant-3-prime
rs1213387 -- 35,123,456(+) CTATA(A/C)TGGAA intron-variant
rs998658 -- 35,119,726(+) ACCAC(A/G)TCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CUL2 Gene

Variant ID Type Subtype PubMed ID
dgv632n71 CNV Gain 21882294
nsv466860 CNV Gain 19166990
nsv895015 CNV Gain 21882294
nsv466862 CNV Gain 19166990
nsv470931 CNV Gain 18288195
nsv525060 CNV Gain 19592680
nsv466869 CNV Gain 19166990
dgv633n71 CNV Loss 21882294
nsv466870 CNV Loss 19166990
nsv895019 CNV Gain 21882294
esv2677225 CNV Deletion 23128226
nsv507549 CNV Insertion 20534489
nsv895020 CNV Gain 21882294

Variation tolerance for CUL2 Gene

Residual Variation Intolerance Score: 8.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 19.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CUL2 Gene

HapMap Linkage Disequilibrium report
CUL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CUL2 Gene

Disorders for CUL2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CUL2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
renal cell carcinoma
  • renal cell carcinoma, clear cell, somatic
hypoxia
renal clear cell carcinoma
  • clear cell carcinoma of kidney
familial renal papillary carcinoma
  • hereditary papillary renal carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search CUL2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CUL2

Genetic Association Database (GAD)
CUL2
Human Genome Epidemiology (HuGE) Navigator
CUL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CUL2
genes like me logo Genes that share disorders with CUL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CUL2 Gene

Publications for CUL2 Gene

  1. cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. (PMID: 8681378) Kipreos E.T. … Hedgecock E.M. (Cell 1996) 2 3 4 67
  2. Mammalian SWI/SNF--a subunit BAF250/ARID1 is an E3 ubiquitin ligase that targets histone H2B. (PMID: 20086098) Li X.S. … Tanese N. (Mol. Cell. Biol. 2010) 3 23
  3. Phosphorylation of NF-kappaB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination. (PMID: 19270718) Geng H. … Schmitz M.L. (EMBO Rep. 2009) 3 23
  4. Regulation of DNA topoisomerase IIalpha stability by the ECV ubiquitin ligase complex. (PMID: 19695223) Yun J. … Choi C.H. (Biochem. Biophys. Res. Commun. 2009) 3 23
  5. Mutational analysis of hypoxia-related genes HIF1alpha and CUL2 in common human cancers. (PMID: 20078552) Park S.W. … Lee S.H. (APMIS 2009) 3 23

Products for CUL2 Gene

Sources for CUL2 Gene

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