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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CUL2 Gene

protein-coding   GIFtS: 64
GCID: GC10M035338

cullin 2
 Explore 17 diseases affiliated with
CUL2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CUL2    

Aliases
for CUL2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cullin 21 2
CUL-22 3
Cullin-21

External Ids:    HGNC: 25521   Entrez Gene: 84532   Ensembl: ENSG000001080947   OMIM: 6031355   UniProtKB: Q136173   

Export aliases for CUL2 gene to outside databases

Previous GC identifers: GC10M035046 GC10M035449 GC10M035302


Summaries
for CUL2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: CUL2_HUMAN, Q13617
Function: Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein
ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex
and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3
ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is
inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional
specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of
hypoxia-inducible factor (HIF)

Gene Wiki entry for CUL2


Genomic Views
for CUL2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CUL2 gene promoter:
         ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CUL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CUL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CUL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p11.21   Ensembl cytogenetic band:  10p11.21   HGNC cytogenetic band: 10p11.2

CUL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CUL2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M035338:  view genomic region     (about GC identifiers)

Start:
 35,297,479 bp from pter      End:
 35,379,570 bp from pter
Size:
 82,092 bases      Orientation:
 minus strand

Proteins
for CUL2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CUL2_HUMAN, Q13617 (See protein sequence)
Recommended Name: Cullin-2  
Size: 745 amino acids; 86983 Da
Subunit: Component of multiple ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes formed of
CUL2, Elongin BC (TCEB1 and TCEB2), RBX1 and a variable substrate-specific adapter. Component of the ECS(VHL) or
CBC(VHL) complex containing VHL. Component of the ECS(MED8) complex with the probable substrate recognition component
MED8 (By similarity). Component of the ECS(LRR1) complex with the probable substrate recognition component LRR1.
Component of a probable ECS E3 ubiquitin-protein ligase complex containing CUL2, RBX1, TCEB1, TCEB2 and FEM1B. Part of
an E3 ubiquitin-protein ligase complex including ZYG11B, CUL2 and Elongin BC. Part of an E3 ubiquitin-protein ligase
complex including ZYG11BL, CUL2 and Elongin BC. Interacts with RBX1, RNF7, FEM1B and TIP120A/CAND1. Interacts with
COPS2, and MED8 (By similarity). Interacts with human respiratory syncytial virus (HRSV) protein NS1. Found in a
complex composed of LIMD1, VHL, EGLN1/PHD2, TCEB2 AND CUL2
Secondary accessions: B3KT95 B7Z6K8 D3DRY6 G3V1S2 O00200 Q5T2B6 Q9UNF9
Alternative splicing: 2 isoforms:  Q13617-1   Q13617-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CUL2: NX_Q13617

Post-translational modifications:

  • CBC(VHL) complex formation seems to promote neddylation. Deneddylated via its interaction with the COP9 signalosome
    • (CSN) complex (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13617

    • CUL2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001185706.1  NP_001185707.1  NP_001185708.1  NP_003582.2  

    ENSEMBL proteins: 
     ENSP00000363883   ENSP00000363880   ENSP00000363878   ENSP00000363881   ENSP00000363886  
     ENSP00000414095   ENSP00000444856   ENSP00000363874  
    Reactome Protein details: Q13617
    Human Recombinant Protein Products: 
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    Novus Biologicals CUL2 Proteins
    Novus Biologicals CUL2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CUL2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0031461cullin-RING ubiquitin ligase complex ----
    GO:0031462Cul2-RING ubiquitin ligase complex IDA17636018


    CUL2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CUL2

    Protein Domains /
    Families
    for CUL2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CUL2 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR016159 Cullin_repeat-like_dom
     IPR019559 Cullin_neddylation_domain
     IPR016157 Cullin_CS
     IPR001373 Cullin_N
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q13617

    ProtoNet protein and cluster: Q13617

    1 Blocks protein family: IPB001373 Cullin

    UniProtKB/Swiss-Prot: CUL2_HUMAN, Q13617
    Similarity: Belongs to the cullin family


    Function
    for CUL2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CUL2_HUMAN, Q13617
    Function: Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein
    ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex
    and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3
    ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is
    inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional
    specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of
    hypoxia-inducible factor (HIF)

         Genatlas biochemistry entry for CUL2:
    cullin 2,complexing with VHL/elongin B and C to form an ubiquitin-ligase complex referred to VCB-CUL2(see
    VHL),putatively targetting certain proteins for degradation,not a major renal cell carcinoma,tumor suppressor gene,but
    maybe involved in other carcinomas,see TSG10

    miRNA
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    hsa-mir-424 (MIRT005927)

    OriGene 3'-UTR Clone: CUL2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CUL2
    8/61 QIAGEN miScript miRNA Assays for microRNAs that regulate CUL2 (see all 61):
    hsa-miR-323-3p hsa-miR-4291 hsa-miR-142-5p hsa-miR-15a hsa-miR-574-3p hsa-miR-1260b hsa-miR-3653 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmid: CUL2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CUL2 (see all 7)
    OriGene shRNA RFP: CUL2
    OriGene siRNA: CUL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CUL2

    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for CUL2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUL2

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0031625ubiquitin protein ligase binding IDA17636018


    CUL2 for ontologies           About GeneDecksing


    9 GenomeRNAi human phenotypes for CUL2:
     Decreased viability of wild-ty  Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  G0/1 arrest 
     Increased G1 DNA content  Increased cell death in HCT116  Increased cell death in breast  Increased cell number in G1, s 
     Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for CUL2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
    		Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha1.00
    		Destruction of Ubiquitinated HIF-alpha by the Proteasome0.67
    		Cellular response to hypoxia0.72
    		Nuclear Export of Ubiquitinated HIF-alpha:VHL:EloB/C:CUL2:RBX1 Complex0.67
    		Cellular responses to stress0.72
    		Hypoxic and oxygen homeostasis regulation of HIF-1-alpha0.27
    		Regulation of Hypoxia-inducible Factor (HIF) by Oxygen0.72
    2Antigen processing: Ubiquitination & Proteasome degradation
    		Antigen processing: Ubiquitination & Proteasome degradation1.00
    		Polyubiquitination of substrate0.75
    		Class I MHC mediated antigen processing & presentation0.83
    		Ubiquitin mediated proteolysis0.36
    3Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    4TGF-Beta Pathway
    		JAK-STAT Pathway0.57
    		SOCS Pathway0.29
    5HIF1Alpha Pathway
    		HIF1Alpha Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CUL2
        HIF1Alpha Pathway
    JAK-STAT Pathway
    SOCS Pathway

    1 BioSystems Pathway for CUL2 
        Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

    5/11        Reactome Pathways for CUL2 (see all 11)
        Cellular response to hypoxia
    Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
    Polyubiquitination of substrate
    Adaptive Immune System
    Cellular responses to stress


    3         Kegg Pathways  (Kegg details for CUL2):
        Ubiquitin mediated proteolysis
    Pathways in cancer
    Renal cell carcinoma

    UniProtKB/Swiss-Prot: CUL2_HUMAN, Q13617
    Pathway: Protein modification; protein ubiquitination


    CUL2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CUL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/169 Interacting proteins for CUL2 (Q136171, 2, 3 ENSP000003638804) via UniProtKB, MINT, STRING, and/or I2D (see all 169)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCEB1Q153692, 3, ENSP000002848114MINT-4140881 MINT-7014221 MINT-6543008 MINT-8295435 MINT-7014239 MINT-8295568 MINT-8295466 MINT-6542668 MINT-8295501 MINT-8295600 MINT-7014201 MINT-8295545 I2D: score=7 STRING: ENSP00000284811
    TCEB2Q153702, 3, ENSP000002623064MINT-7014221 MINT-6543008 MINT-8295435 MINT-7014239 MINT-8295568 MINT-8295466 MINT-6542668 MINT-7014201 MINT-8295545 I2D: score=2 STRING: ENSP00000262306
    RBX1P628772, 3, ENSP000002162254MINT-7014221 MINT-8295435 MINT-7014239 MINT-7014201 MINT-4140852 I2D: score=4 STRING: ENSP00000216225
    COMMD1Q8N6682, 3, ENSP000003082364MINT-4140802 MINT-4140816 MINT-4140831 I2D: score=3 STRING: ENSP00000308236
    RELAQ042062, 3, ENSP000003842734MINT-7014239 I2D: score=2 STRING: ENSP00000384273
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS8681378
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0007050cell cycle arrest TAS8681378
    GO:0008285negative regulation of cell proliferation TAS8681378
    GO:0016567protein ubiquitination IEA--


    CUL2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CUL2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CUL2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CUL2
    1 Novoseek chemical compound relationship for CUL2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nickel 23.7 2 16097032 (1), 11779168 (1)

    Search CenterWatch for drugs/clinical trials and news about CUL2 

    Transcripts
    for CUL2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CUL2 gene (4 alternative transcripts): 
    NM_001198777.1  NM_001198778.1  NM_001198779.1  NM_003591.3  

    Unigene Cluster for CUL2:

    Cullin 2
    Hs.82919  [show with all ESTs]
    Unigene Representative Sequence: NM_001198779
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374751(uc001ixw.3) ENST00000374748 ENST00000374746 ENST00000374749(uc021ppa.1 uc010qer.2 uc009xma.3 uc001ixv.3 uc010qes.2)
    ENST00000374754 ENST00000421317 ENST00000468804 ENST00000478044 ENST00000537177
    ENST00000374742

    miRNA
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    8/61 QIAGEN miScript miRNA Assays for microRNAs that regulate CUL2 (see all 61):
    hsa-miR-323-3p hsa-miR-4291 hsa-miR-142-5p hsa-miR-15a hsa-miR-574-3p hsa-miR-1260b hsa-miR-3653 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmid: CUL2 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CUL2
    Clone
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    Primer
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    Additional cDNA sequence: 

    AF126404.1 AK095217.1 AK294080.1 AK300491.1 AK310225.1 AL832733.1 BC009591.1 BC095405.1 
    BC110901.1 U58088.1 U83410.1 

    12 DOTS entries:

    DT.75164500  DT.443924  DT.100794071  DT.121286517  DT.92430857  DT.97788261  DT.100667900  DT.116161 
    DT.121286430  DT.92430859  DT.95277957  DT.95277953 

    24/207 AceView cDNA sequences (see all 207):

    BC009591 BE464164 CF529216 BQ012915 AA325660 AI352018 AI953367 NM_003591 
    AI991737 BQ225809 BM454670 AA608922 AI089201 BP335520 AF126404 AW613421 
    BG031734 BX384597 BM552099 BQ720615 AI394320 AW300503 AI473563 AA345217 

    GeneLoc Exon Structure


    Expression
    for CUL2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CUL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATACTGCTGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CUL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CUL2

    SOURCE GeneReport for Unigene cluster: Hs.82919
        SABiosciences Expression via Pathway-Focused PCR Arrays including CUL2: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Parkinson's Disease in human mouse rat
              Cell Cycle in human mouse rat
              Apoptosis 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUL2

    Orthologs
    for CUL2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CUL2 gene from 7/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cul21 , 5 cullin 21, 5 91.36(n)1
    97.32(a)1    		   18 (2.21 cM)5
    717451  NM_029402.31  NP_083678.21 
     33829885 
    chicken
    (Gallus gallus)    		 Aves CUL21 cullin 2 87.81(n)
    96.66(a)    		   420467  NM_001030970.1  NP_001026141.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CUL26
    		 --
    		 94(a)
    		 1 ↔ 1
    		 6(10866515-10898489)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC691672 hypothetical protein MGC69167 80.53(n)    BC059348.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufj48a062 Transcribed sequence with weak similarity to protein more 79.4(n)    BM095257.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta cul-23
    Cul-21    		 Cullin-21 50(a)3
    54.29(n)1
    51.76(a)1    		   39E63
    354201  NM_165390.11  NP_724352.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea cul-21 Protein CUL-2 50.81(n)
    45.27(a)    		   176806  NM_067424.3  NP_499825.3 


    ENSEMBL Gene Tree for CUL2 (if available)
    TreeFam Gene Tree for CUL2 (if available) 

    Paralogs
    for CUL2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CUL2 gene
    CUL12  CUL32  CUL4B2  CUL4A2  CUL52  
    5 SIMAP similar genes for CUL2 using alignment to 4 protein entries:     CUL2_HUMAN (see all proteins):
    CUL1    CUL4B    CUL3    CUL4A    CUL5

    CUL2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CUL2
    PGOHUM00000243839


    Genomic Variants
    for CUL2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1453 NCBI SNPs in CUL2 are shown (see all 1453)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1411716871,2
    		--35297061(+) TTTTCA/CTAGCT 4 -- int10--------
    rs23842751,2
    		C,F,A,H,--35297142(+) GCTACA/GGCTTC 4 -- int116Minor allele frequency- G:0.38NS EA NA WA CSA 757
    rs1450000751,2
    		--35297172(+) TCCTGA/GCCTAA 4 -- int10--------
    rs1849118661,2
    		--35297222(+) GGAAGA/GTGTGC 4 -- int10--------
    rs1867533951,2
    		--35297304(+) TCATGC/TGAGAG 4 -- int10--------
    rs23842761,2
    		C,F,O,A,H,--35297305(+) CATGCG/AAGAGA 4 -- int119Minor allele frequency- A:0.15NS EA NA WA 2444
    rs1916088101,2
    		--35297339(+) GAAAGA/GATGTG 4 -- int10--------
    rs1480583751,2
    		--35297380(+) CCTCCA/GCACAA 4 -- int10--------
    rs455551381,2
    		--35297385(+) GCACAA/TGTATT 4 -- int10--------
    rs1409088281,2
    		--35297475(+) AAAAAG/TGAATC 4 -- int10--------

    HapMap Linkage Disequilibrium report for CUL2 (35297479 - 35379570 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for CUL2
         4 CNVs: 29587 29585 29588 29586
         1 Indel: 39741

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    Disorders / Diseases
    for CUL2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CUL2 for disorders           About GeneDecksing

    OMIM gene information: 603135    OMIM disorders: --

    17 diseases for CUL2:    About MalaCards
    von hippel-lindau disease    renal clear cell carcinoma    renal cell carcinoma    hemangioma
    crohn's disease    kidney disease    parkinson's disease    kidney cancer
    pheochromocytoma    alzheimer's disease    retinoblastoma    carcinoma
    glioblastoma    hypoxia    melanoma    malaria
    leukemia

    2 diseases from the University of Copenhagen DISEASES database for CUL2:
    Hemangioma     Renal cell carcinoma

    3 Novoseek disease relationships for CUL2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    von hippel-lindau disease 70.4 1 11278610 (1)
    tumors 35.2 7 10318914 (2), 10441001 (2), 9447969 (1), 10585493 (1) (see all 5)
    cancer 9.3 6 20078552 (4), 10441001 (1)

    Genetic Association Database (GAD): CUL2
    Human Genome Epidemiology (HuGE) Navigator: CUL2 (5 documents)

    Export disorders for CUL2 gene to outside databases

    Publications
    for CUL2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CUL2 gene, integrated from 9 sources (see all 149):
    (articles sorted by number of sources associating them with CUL2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. (PubMed id 8681378)1, 2, 3 Kipreos E.T.... Hedgecock E.M. (1996)
    2. Identification of NEDD8-conjugation site in human cullin-2. (PubMed id 10092517)1, 2, 9 Wada H.... Kamitani T. (1999)
    3. The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. (PubMed id 22286099)1, 2 Foxler D.E.... Sharp T.V. (2012)
    4. The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components. (PubMed id 17304241)1, 2 Vasudevan S.... Kipreos E.T. (2007)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. TIP120A associates with cullins and modulates ubiquitin ligase activity. (PubMed id 12609982)1, 2 Min K.-W.... Yoon J.-B. (2003)
    9. Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. (PubMed id 12149480)1, 2 Brower C.S.... Conaway R.C. (2002)
    10. Muf1, a novel elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase. (PubMed id 11384984)1, 2 Kamura T.... Conaway J.W. (2001)

    External Searches for CUL2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CUL2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8453 HGNC: 2552 AceView: CUL2 Ensembl:ENSG00000108094 euGenes: HUgn8453
    ECgene: CUL2 Kegg: 8453 H-InvDB: CUL2

    Other Databases showing CUL2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CUL2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CUL2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CUL2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CUL2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CUL2 gene:
    Search GeneIP for patents involving CUL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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