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CUL2 Gene

protein-coding   GIFtS: 65
GCID: GC10M035338

Cullin 2

  See CUL2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cullin 21 2
CUL-22 3
cullin-22

External Ids:    HGNC: 25521   Entrez Gene: 84532   Ensembl: ENSG000001080947   OMIM: 6031355   UniProtKB: Q136173   

Export aliases for CUL2 gene to outside databases

Previous GC identifers: GC10M035046 GC10M035449 GC10M035302


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CUL2 Gene:
CUL2 (cullin 2) is a protein-coding gene. Diseases associated with CUL2 include glomuvenous malformation. GO annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is CUL1.

UniProtKB/Swiss-Prot: CUL2_HUMAN, Q13617
Function: Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3
ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid
scaffold in the complex and may contribute to catalysis through positioning of the substrate and the
ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the
neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with
TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition
component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF)

Gene Wiki entry for CUL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_008705.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CUL2 gene promoter:
         ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCUL2 promoter sequence
   Search Chromatin IP Primers for CUL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CUL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p11.21   Ensembl cytogenetic band:  10p11.21   HGNC cytogenetic band: 10p11.2

CUL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CUL2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M035338:  view genomic region     (about GC identifiers)

Start:
35,297,479 bp from pter      End:
35,379,570 bp from pter
Size:
82,092 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CUL2_HUMAN, Q13617 (See protein sequence)
Recommended Name: Cullin-2  
Size: 745 amino acids; 86983 Da
Subunit: Component of multiple ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes
formed of CUL2, Elongin BC (TCEB1 and TCEB2), RBX1 and a variable substrate-specific adapter. Component of the
ECS(VHL) or CBC(VHL) complex containing VHL. Component of the ECS(MED8) complex with the probable substrate
recognition component MED8. Component of the ECS(LRR1) complex with the probable substrate recognition component
LRR1. Component of a probable ECS E3 ubiquitin-protein ligase complex containing CUL2, RBX1, TCEB1, TCEB2 and
FEM1B. Part of an E3 ubiquitin-protein ligase complex including ZYG11B, CUL2 and Elongin BC. Part of an E3
ubiquitin-protein ligase complex including ZYG11BL, CUL2 and Elongin BC. Interacts with RBX1, RNF7, FEM1B and
TIP120A/CAND1. Interacts with COPS2, and MED8. Interacts with human respiratory syncytial virus (HRSV) protein
NS1. Found in a complex composed of LIMD1, VHL, EGLN1/PHD2, TCEB2 and CUL2. Interacts with KLHDC10; which may be
an E3 ubiquitin ligase complex substrate recognition component
Secondary accessions: B3KT95 B7Z6K8 D3DRY6 G3V1S2 O00200 Q5T2B6 Q9UNF9
Alternative splicing: 2 isoforms:  Q13617-1   Q13617-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CUL2: NX_Q13617

Explore proteomics data for CUL2 at MOPED

Post-translational modifications: 

  • CBC(VHL) complex formation seems to promote neddylation. Deneddylated via its interaction with the COP9
    signalosome (CSN) complex (By similarity)1
  • Ubiquitination2 at Lys16, Lys608
  • Modification sites at PhosphoSitePlus

  • See CUL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001185706.1  NP_001185707.1  NP_001185708.1  NP_003582.2  

    ENSEMBL proteins: 
     ENSP00000363878   ENSP00000363880   ENSP00000363881   ENSP00000363883   ENSP00000363886  
     ENSP00000414095   ENSP00000444856   ENSP00000363874   ENSP00000473659  
    Reactome Protein details: Q13617

    CUL2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for CUL2
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    OriGene MassSpec for CUL2
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    Novus Biologicals CUL2 Proteins
    Novus Biologicals CUL2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CUL2

     
    Search eBioscience for Proteins for CUL2 

    CUL2 Antibody Products:

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    Novus Biologicals CUL2 Antibodies
    Abcam antibodies for CUL2
    Cloud-Clone Corp. Antibodies for CUL2
    ThermoFisher Antibodies for CUL2
    LSBio Antibodies in human, mouse, rat for CUL2

    CUL2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CUL2
    Cloud-Clone Corp. CLIAs for CUL2
    Search eBioscience for ELISAs for CUL2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR016159 Cullin_repeat-like_dom
     IPR019559 Cullin_neddylation_domain
     IPR016157 Cullin_CS
     IPR001373 Cullin_N
     IPR011991 WHTH_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q13617

    ProtoNet protein and cluster: Q13617

    1 Blocks protein domain: IPB001373 Cullin

    UniProtKB/Swiss-Prot: CUL2_HUMAN, Q13617
    Similarity: Belongs to the cullin family


    Find genes that share domains with CUL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CUL2_HUMAN, Q13617
    Function: Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3
    ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid
    scaffold in the complex and may contribute to catalysis through positioning of the substrate and the
    ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the
    neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with
    TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition
    component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF)

         Genatlas biochemistry entry for CUL2:
    cullin 2,complexing with VHL/elongin B and C to form an ubiquitin-ligase complex referred to VCB-CUL2(see
    VHL),putatively targetting certain proteins for degradation,not a major renal cell carcinoma,tumor suppressor
    gene,but maybe involved in other carcinomas,see TSG10

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12504026
    GO:0031625ubiquitin protein ligase binding IDA17636018
    GO:0032403protein complex binding IEA--
         
    Find genes that share ontologies with CUL2           About GenesLikeMe


    Phenotypes:
         9 GenomeRNAi human phenotypes for CUL2:
     Decreased viability of wild-ty  Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  G0/1 arrest 
     Increased G1 DNA content  Increased cell death in HCT116  Increased cell death in breast  Increased cell number in G1, s 
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CUL2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CUL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CUL2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CUL2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CUL2:
    hsa-let-7b-5p (MIRT052315), hsa-mir-30c-5p (MIRT007130), hsa-mir-93-3p (MIRT038756), hsa-mir-100-5p (MIRT048406), hsa-mir-4326 (MIRT052839), hsa-mir-99a-5p (MIRT048623), hsa-mir-424-5p (MIRT005927)

    Block miRNA regulation of human, mouse, rat CUL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CUL2 (see all 61):
    hsa-miR-323-3p hsa-miR-4291 hsa-miR-142-5p hsa-miR-15a hsa-miR-574-3p hsa-miR-1260b hsa-miR-3653 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidCUL2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CUL2
    Predesigned siRNA for gene silencing in human, mouse, rat CUL2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CUL2

    Clone
    Products:
         
    OriGene clones in human, mouse for CUL2 (see all 14)
    OriGene ORF clones in mouse, rat for CUL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CUL2 (NM_001198778)
    Sino Biological Human cDNA Clone for CUL2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CUL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUL2
    Addgene plasmids for CUL2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CUL2
    Browse ESI BIO Cell Lines and PureStem Progenitors for CUL2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005829cytosol TAS--
    GO:0030891VCB complex IEA--

    Find genes that share ontologies with CUL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CUL2 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    2Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
    Regulation of Hypoxia-inducible Factor (HIF) by Oxygen1.00
    Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha0.00
    Cellular response to hypoxia1.00
    3TGF-Beta Pathway
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    4Cellular Senescence
    Cellular responses to stress0.81
    5Renal cell carcinoma
    Renal cell carcinoma


    Find genes that share SuperPaths with CUL2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CUL2
        HIF1Alpha Pathway
    JAK-STAT Pathway
    SOCS Pathway

    1 BioSystems Pathway for CUL2
        Hypoxic and oxygen homeostasis regulation of HIF-1-alpha


    2 Reactome Pathways for CUL2
        Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
    Antigen processing: Ubiquitination & Proteasome degradation


    4 Kegg Pathways  (Kegg details for CUL2):
        HIF-1 signaling pathway
    Ubiquitin mediated proteolysis
    Pathways in cancer
    Renal cell carcinoma

    UniProtKB/Swiss-Prot: CUL2_HUMAN, Q13617
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CUL2: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Parkinson's Disease in human mouse rat
              Cell Cycle in human mouse rat
              Apoptosis 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CUL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CUL2 (Q136171, 2, 3 ENSP000003638804) via UniProtKB, MINT, STRING, and/or I2D (see all 183)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCEB1Q153691, 2, 3, ENSP000002848114EBI-456179,EBI-301231 MINT-4140881 MINT-7014221 MINT-6543008 MINT-8295435 MINT-7014239 MINT-8295568 MINT-8295466 MINT-6542668 MINT-8295501 MINT-8295600 MINT-7014201 MINT-8295545 I2D: score=7 STRING: ENSP00000284811
    TCEB2Q153702, 3, ENSP000002623064MINT-7014221 MINT-6543008 MINT-8295435 MINT-7014239 MINT-8295466 MINT-8295568 MINT-6542668 MINT-7014201 MINT-8295545 I2D: score=2 STRING: ENSP00000262306
    RBX1P628771, 2, 3, ENSP000002162254EBI-456179,EBI-398523 MINT-7014221 MINT-8295435 MINT-7014239 MINT-7014201 MINT-4140852 I2D: score=4 STRING: ENSP00000216225
    COMMD1Q8N6681, 2, 3, ENSP000003082364EBI-456179,EBI-1550112 MINT-4140802 MINT-4140816 MINT-4140831 I2D: score=3 STRING: ENSP00000308236
    RELAQ042062, 3, ENSP000003842734MINT-7014239 I2D: score=2 STRING: ENSP00000384273
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS8681378
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0007050cell cycle arrest TAS8681378
    GO:0008285negative regulation of cell proliferation TAS8681378
    GO:0016032viral process IEA--

    Find genes that share ontologies with CUL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CUL2

    1 Novoseek inferred chemical compound relationship for CUL2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nickel 23.7 2 16097032 (1), 11779168 (1)



    Find genes that share compounds with CUL2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CUL2 gene (4 alternative transcripts): 
    NM_001198777.1  NM_001198778.1  NM_001198779.1  NM_003591.3  

    Unigene Cluster for CUL2:

    Cullin 2
    Hs.82919  [show with all ESTs]
    Unigene Representative Sequence: NM_001198779
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374746 ENST00000374748 ENST00000374749(uc021ppa.1 uc010qer.2 uc009xma.3 uc001ixv.3 uc010qes.2)
    ENST00000374751(uc001ixw.3) ENST00000374754 ENST00000421317 ENST00000468804
    ENST00000478044 ENST00000537177 ENST00000374742 ENST00000602371
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CUL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CUL2 (see all 61):
    hsa-miR-323-3p hsa-miR-4291 hsa-miR-142-5p hsa-miR-15a hsa-miR-574-3p hsa-miR-1260b hsa-miR-3653 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidCUL2 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat CUL2
    Clone
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    OriGene clones in human, mouse for CUL2 (see all 14)
    OriGene ORF clones in mouse, rat for CUL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CUL2 (NM_001198778)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CUL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUL2
    Addgene plasmids for CUL2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CUL2
    OriGene qSTAR qPCR primer pairs in human, mouse for CUL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CUL2
      QuantiTect SYBR Green Assays in human, mouse, rat CUL2
      QuantiFast Probe-based Assays in human, mouse, rat CUL2

    Additional mRNA sequence: 

    AF126404.1 AK095217.1 AK294080.1 AK300491.1 AK310225.1 AL832733.1 BC009591.1 BC095405.1 
    BC110901.1 U58088.1 U83410.1 

    12 DOTS entries:

    DT.75164500  DT.443924  DT.100794071  DT.121286517  DT.92430857  DT.97788261  DT.100667900  DT.116161 
    DT.121286430  DT.92430859  DT.95277957  DT.95277953 

    Selected AceView cDNA sequences (see all 207):

    BU624879 BG031734 BM988515 CA438118 BX384597 BM552099 BQ720615 BE464164 
    AW613421 AI394320 AW300503 AA608922 BC009591 BQ225809 AI352018 AF126404 
    AA345217 BM454670 AI473563 AI089201 AI991737 NM_003591 CB163485 AA147389 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CUL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATACTGCTGC
    CUL2 Expression
    About this image

    CUL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CUL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.82919
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CUL2: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Parkinson's Disease in human mouse rat
              Cell Cycle in human mouse rat
              Apoptosis 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CUL2
    OriGene qSTAR qPCR primer pairs in human, mouse for CUL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CUL2
    QuantiTect SYBR Green Assays in human, mouse, rat CUL2
    QuantiFast Probe-based Assays in human, mouse, rat CUL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CUL2 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cul21 , 5 cullin 21, 5 91.36(n)1
    97.32(a)1
      18 (2.21 cM)5
    717451  NM_029402.31  NP_083678.21 
     33829885 
    chicken
    (Gallus gallus)
    Aves CUL21 cullin 2 87.81(n)
    96.66(a)
      420467  NM_001030970.1  NP_001026141.1 
    lizard
    (Anolis carolinensis)
    Reptilia CUL26
    cullin 2
    93(a)
    1 ↔ 1
    6(10864238-10899058)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC691672 hypothetical protein MGC69167 80.53(n)    BC059348.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj48a062 Transcribed sequence with weak similarity to protein more 79.4(n)    BM095257.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cul-23
    Cul-21
    Cullin-21 50(a)3
    54.2(n)1
    51.9(a)1
      39E63
    354201  NM_165390.21  NP_724352.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cul-21 cul-2 50.65(n)
    45.21(a)
      176806  NM_067424.4  NP_499825.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC536
    Cullin, structural protein of SCF complexes (which...
    27(a)
    1 → many
    IV(224304-226751) YDL132W


    ENSEMBL Gene Tree for CUL2 (if available)
    TreeFam Gene Tree for CUL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CUL2 gene
    CUL12  CUL32  CUL4A2  CUL4B2  CUL52  
    5 SIMAP similar genes for CUL2 using alignment to 5 protein entries:     CUL2_HUMAN (see all proteins):
    CUL1    CUL4B    CUL3    CUL4A    CUL5

    Find genes that share paralogs with CUL2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CUL2
    PGOHUM00000243839


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for CUL2 (see all 1668)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs567766321,2
    C--35083267(+) CACAC-/AC/A  
     CACACAC
    GCACG
    4 -- int1 us2k11NA 2
    rs1411716871,2
    --35297061(+) TTTTCA/CTAGCT 4 -- int10--------
    rs23842751,2
    C,F,A,H--35297142(+) GCTACA/GGCTTC 4 -- int116Minor allele frequency- G:0.38NS EA NA WA CSA 757
    rs1450000751,2
    --35297172(+) TCCTGA/GCCTAA 4 -- int10--------
    rs1849118661,2
    --35297222(+) GGAAGA/GTGTGC 4 -- int10--------
    rs1867533951,2
    --35297304(+) TCATGC/TGAGAG 4 -- int10--------
    rs23842761,2
    C,F,O,A,H--35297305(+) CATGCG/AAGAGA 4 -- int119Minor allele frequency- A:0.15NS EA NA WA 2444
    rs1916088101,2
    --35297339(+) GAAAGA/GATGTG 4 -- int10--------
    rs1480583751,2
    --35297380(+) CCTCCA/GCACAA 4 -- int10--------
    rs455551381,2
    --35297385(+) GCACAA/TGTATT 4 -- int10--------

    HapMap Linkage Disequilibrium report for CUL2 (35297479 - 35379570 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CUL2 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677225CNV Deletion23128226
    nsv507549CNV Insertion20534489
    nsv466870CNV Loss19166990
    dgv633n71CNV Loss21882294
    nsv895020CNV Gain21882294
    dgv632n71CNV Gain21882294
    nsv525060CNV Gain19592680
    nsv466860CNV Gain19166990
    nsv895015CNV Gain21882294
    nsv466869CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CUL2
    DNA2.0 Custom Variant and Variant Library Synthesis for CUL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603135    OMIM disorders: --

    1 disease for CUL2:    
    About MalaCards
    glomuvenous malformation

    2 diseases from the University of Copenhagen DISEASES database for CUL2:
    Hemangioma     Renal cell carcinoma

    Find genes that share disorders with CUL2           About GenesLikeMe

    3 Novoseek inferred disease relationships for CUL2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    von hippel-lindau disease 70.4 1 11278610 (1)
    tumors 35.2 7 10318914 (2), 10441001 (2), 9447969 (1), 10585493 (1) (see all 5)
    cancer 9.3 6 20078552 (4), 10441001 (1)

    Genetic Association Database (GAD): CUL2
    Human Genome Epidemiology (HuGE) Navigator: CUL2 (5 documents)

    Export disorders for CUL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CUL2 gene, integrated from 10 sources (see all 164):
    (articles sorted by number of sources associating them with CUL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. (PubMed id 8681378)1, 2, 3 Kipreos E.T.... Hedgecock E.M. (Cell 1996)
    2. Mutational analysis of hypoxia-related genes HIF1alpha and CUL2 in common human cancers. (PubMed id 20078552)1, 4, 9 Park S.W....Lee S.H. (APMIS 2009)
    3. Identification of NEDD8-conjugation site in human cullin-2. (PubMed id 10092517)1, 2, 9 Wada H.... Kamitani T. (Biochem. Biophys. Res. Commun. 1999)
    4. The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. (PubMed id 22286099)1, 2 Foxler D.E.... Sharp T.V. (Nat. Cell Biol. 2012)
    5. Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients. (PubMed id 19760754)1, 4 TAPrkvist L....Pettersson S. (Inflamm. Bowel Dis. 2010)
    6. KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise. (PubMed id 18984674)1, 4 Argyropoulos G....Rankinen T. (Physiol. Genomics 2009)
    7. The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components. (PubMed id 17304241)1, 2 Vasudevan S.... Kipreos E.T. (EMBO Rep. 2007)
    8. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 8453 HGNC: 2552 AceView: CUL2 Ensembl:ENSG00000108094 euGenes: HUgn8453
    ECgene: CUL2 Kegg: 8453 H-InvDB: CUL2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CUL2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CUL2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CUL2 gene:
    Search GeneIP for patents involving CUL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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