CUL1 Gene
protein-coding GIFtS: 66
GCID: GC07P148395
|
|
cullin 1
| |
Aliases
for CUL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cullin 11 2 | | CUL-12 3 | | Cullin-11 |
Export aliases for CUL1 gene to outside databasesPrevious GC identifers: GC07P146673 GC07P147710 GC07P147787 GC07P147833 GC07P148026 GC07P142474 |
Summaries
for CUL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CUL1_HUMAN, Q13616Function: Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligasecomplexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction andtranscription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits.May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and isinhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of theSCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) directubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylatedNFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2.SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition.SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1.SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directsubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) does not seem to directubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradationfrees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F)directs ubiquitination of CP110 (By similarity)
Gene Wiki entry for CUL1
|
Genomic Views
for CUL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CUL1 gene promoter:
FOXO3 FOXO3a FOXO1a MyoD FOXO3b FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CUL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CUL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q36.1 Ensembl cytogenetic band: 7q36.1 HGNC cytogenetic band: 7q36.1CUL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P148395: view genomic region
(about GC identifiers)
Start:
|
148,395,006 bp from pter |
End:
|
148,498,202 bp from pter |
Size:
|
103,197 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 147,733,888-147,836,155 |
|
Proteins
for CUL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CUL1_HUMAN, Q13616 (See
protein sequence)Recommended Name: Cullin-1 Size: 776 amino acids; 89679 Da
Subunit: Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1and a variable F-box domain-containing protein as substrate-specific subunit. Component of the SCF(FBXW11) complexcontaining FBXW11. Component of the SCF(SKP2) complex containing SKP2, in which it interacts directly with SKP1, SKP2and RBX1. Component of the SCF(FBXW2) complex containing FBXw2. Component of the SCF(FBXO32) complex containingFBXO32. Component of the probable SCF(FBXO7) complex containing FBXO7. Component of the SCF(FBXO11) complex containingFBXO11. Component of the SCF(FBXO25) complex containing FBXO25. Component of the SCF(FBXO33) complex containingFBXO33. Component of the probable SCF(FBXO4) complex containing FBXO4. Component of the SCF(FBXO44) complex, composedof SKP1, CUL1 and FBXO44. Interacts with RNF7. Part of a complex with TIP120A/CAND1 and RBX1. The unneddylated forminteracts with TIP120A/CAND1 and the interaction negatively regulates the association with SKP1 in the SCF complex.Interacts with COPS2. Can self-associate. Interacts with FBXW8. Interacts with CUL7; the interaction seems to bemediated by FBXW8. Component of the SCF(BTRC) complex, composed of SKP1, CUL1 and BTRC. This complex bindsphosphorylated NFKBIA. Part of a SCF complex consisting of CUL1, RBX1, SKP1 and FBXO2 (By similarity). Component of aSCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Interacts with TRIM21. Interacts with Epstein-Barrvirus BPLF1. Component of the SCF(FBXO17) complex, composed of SKP1, CUL1 and FBXO17. Component of the SCF(FBXO27)complex, composed of SKP1, CUL1 and FBXO27. Component of the SCF(Cyclin F) complex consisting of CUL1, RBX1, SKP1 andCCNF. Interacts with human adenovirus early E1A protein; this interaction inhibits RBX1-CUL1-dependent elongationreaction of ubiquitin chains by the SCF(FBW7) complex. Interacts with CHEK2; mediates CHEK2 ubiquitination andregulates its function
6/7 PDB 3D structures from  and Proteopedia  for CUL1 (see all 7):1LDJ (3D)
1LDK (3D)
1U6G (3D)
3RTR (3D)
3TDU (3D)
3TDZ (3D)
Secondary accessions: D3DWG3 O60719 Q08AL6 Q8IYW1Explore the universe of human proteins at neXtProt for CUL1: NX_Q13616
Post-translational modifications:
Neddylated; which enhances the ubiquitination activity of SCF. Deneddylated via its interaction with the COP9signalosome (CSN) complex. Deneddylated by Epstein-Barr virus BPLF1 leading to a S-phase-like environment that isrequired for efficient replication of the viral genome1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13616
CUL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003583.2
ENSEMBL proteins: ENSP00000387160 ENSP00000326804 Reactome Protein details: Q13616
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
CUL1 for ontologies About GeneDecksing
CUL1 Antibody Products:
Assay Products for CUL1: |
Protein
Domains /
Families
for CUL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CUL1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q13616ProtoNet protein and cluster: Q13616 1 Blocks protein family: IPB001373 Cullin
UniProtKB/Swiss-Prot: CUL1_HUMAN, Q13616Similarity: Belongs to the cullin family |
Function
for CUL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CUL1_HUMAN, Q13616Function: Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligasecomplexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction andtranscription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits.May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and isinhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of theSCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) directubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylatedNFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2.SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition.SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1.SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directsubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) does not seem to directubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradationfrees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F)directs ubiquitination of CP110 (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CUL1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CUL1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CUL1 (NM_003592) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CUL1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUL1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUL1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- | | GO:0031625 | ubiquitin protein ligase binding |
IEA | -- |
CUL1 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for CUL1:
Animal Models:
Mouse knock-outs for CUL1: Cul1tmTye Cul1tm1Rsjo
5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Cul1):
CUL1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CUL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/36 super-pathways (see all 36) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ubiquitinated Orc1 is degraded by the proteasome | | | 2 | Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant | | | 3 | FBXW7 WD mutants do not bind NICD1 | | | 4 | Antigen processing: Ubiquitination & Proteasome degradation | | | 5 | Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/7 EMD Millipore Pathways for CUL1 (see all 7)
1 
Cell Signaling Technology (CST) Pathway for CUL1
5/7  GeneGo (Thomson Reuters) Pathways for CUL1 (see all 7)
5/8  BioSystems Pathways for CUL1 (see all 8)
5/53 
Reactome Pathways for CUL1 (see all 53)
5/7 
Kegg Pathways (Kegg details for CUL1) (see all 7):
UniProtKB/Swiss-Prot: CUL1_HUMAN, Q13616Pathway: Protein modification; protein ubiquitination
CUL1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CUL1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/1048 Interacting proteins for CUL1 (Q136161, 2, 3 ENSP000003268044) via UniProtKB, MINT, STRING, and/or I2D (see all 1048)
| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| SKP1 | P632081, 2, 3, ENSP000002314874 | EBI-359390,EBI-307486 MINT-4304038 MINT-7305060 MINT-8399460 MINT-7305000 MINT-6804066 MINT-6540206 MINT-8198846 I2D:
score=19 STRING: ENSP00000231487 | | RBX1 | P628771, 2, 3, ENSP000002162254 | EBI-359390,EBI-398523 MINT-24857 MINT-17422 MINT-6804066 MINT-6540206 MINT-8198846 I2D:
score=15 STRING: ENSP00000216225 | | BTRC | Q9Y2972, 3, ENSP000003592064 | MINT-4544675 MINT-14454 MINT-49909 I2D:
score=8 STRING: ENSP00000359206 | | COPS5 | Q929052, 3, ENSP000003505124 | MINT-7945693 MINT-7947479 I2D:
score=3 STRING: ENSP00000350512 | | PPP1CA | P621362, 3, ENSP000003260314 | MINT-7945693 MINT-7947479 I2D:
score=2 STRING: ENSP00000326031 |
About this table
Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000080 | G1 phase of mitotic cell cycle |
TAS | -- | | GO:0000082 | G1/S transition of mitotic cell cycle |
TAS | -- | | GO:0000084 | S phase of mitotic cell cycle |
TAS | -- | | GO:0000278 | mitotic cell cycle |
TAS | -- | | GO:0006513 | protein monoubiquitination |
IEA | -- |
CUL1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CUL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CUL1 for compounds About GeneDecksing
 Browse Tocris compounds for CUL1
3 Novoseek chemical compound relationships for CUL1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cysteine |
16.8 |
1 |
17914462 (1) |
| atp |
0 |
1 |
12504026 (1) |
| oxygen |
0 |
1 |
19109186 (2), 19767563 (1) |
Search CenterWatch for drugs/clinical trials and news about CUL1
|
Transcripts
for CUL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CUL1 gene: NM_003592.2 Unigene Cluster for CUL1: Cullin 1 Hs.146806 [show with all ESTs]Unigene Representative Sequence: NM_0035922 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000409469 ENST00000325222(uc010lpg.3 uc003wey.3 uc003wez.3 uc003wfa.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CUL1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CUL1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CUL1 (NM_003592) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CUL1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUL1 |
Additional cDNA sequence: AF062536.1 AK096163.1 AK096505.1 AK296909.1 AK315023.1 BC032806.1 BC034318.1 BC125119.1 BC125120.1 BX537409.1 U58087.1 24/27 DOTS entries (see all 27): DT.449164 DT.100657722 DT.100840125 DT.435047 DT.118924 DT.95239754 DT.100840129 DT.100027687 DT.121092222 DT.100840126 DT.100027686 DT.427987 DT.95290145 DT.80100128 DT.92447345 DT.95264535 DT.100840123 DT.121092220 DT.91839485 DT.92447333 DT.99938086 DT.425280 DT.92447339 DT.121092218 24/449 AceView cDNA sequences (see all 449): CA417430 AK096163 CB241432 BX281216 N45615 AI093409 CA417983 BM785315 BQ001253 AW160679 BQ009218 CB118749 BQ028292 BM714767 AA486790 AL560070 BG391038 CB128666 BQ574313 BQ020773 AI284365 AL046497 AA242801 BI858355
GeneLoc Exon Structure
5/17 Alternative Splicing Database (ASD) splice patterns (SP) for CUL1 (see all 17) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | ^ | 24a | · | 24b | ^ | 25 | ^ | 26a | · | 26b | · | 26c | ^ | 27a | · | 27b | ^ | 28a | · | 28b |
|---|
|
| SP1: | - | | - | | | | | | | | - | | | | | | | | | | | | - | | | | - | | | | | | - | | | | - | | | | - | | | | | | |
| SP2: | - | | - | | | | | | | | - | | | | | | | | | | | | - | | | | - | | | | | | - | | | | - | | | | - | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CUL1
|
Expression
for CUL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CUL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAACCTGCTA
About this image
See CUL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CUL1
SOURCE GeneReport for Unigene cluster: Hs.146806
UniProtKB/Swiss-Prot: CUL1_HUMAN, Q13616Tissue specificity: Expressed in lung fibroblasts
SABiosciences Expression via Pathway-Focused PCR Arrays including CUL1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CUL1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CUL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CUL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CUL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUL1 |
Orthologs
for CUL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CUL1 gene from 6/30 species (see all 30) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CUL11 |
cullin 1 |
83.85(n)
99.87(a) |
|
420783 XM_418878.3 XP_418878.3 |
lizard
(Anolis carolinensis) |
Reptilia |
---- |
-- |
88(a)100(a) |
1 ↔ many1 ↔ many |
6(53299772-53329655) AAWZ02039031(1286-9495) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.238262 |
Xenopus laevis transcribed sequence with moderate similarity to protein spQ13616 (H.sapiens) CUL1_HUMAN CULLIN HOMOLOG 1 (CUL-1) less |
82.19(n) |
|
CA791386.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufc13a102 |
wufc13a10 |
81.95(n) |
|
323883 BC045445.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
lin191 , 3 |
lin-19-like1 |
62(a)
(best of 2)3
59.8(n)1
65.37(a)1 |
|
357421 NM_165571.21 NP_724623.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
cul-11 , 3 |
Cuticlin family3
Protein CUL-11 |
46(a)
(best of 2)3
52.8(n)1
47.42(a)1 |
|
III(10542891-10546537)3
1764661 NM_066908.31 NP_499309.11 |
ENSEMBL Gene Tree for CUL1 (if available)
TreeFam Gene Tree for CUL1 (if available) |
Paralogs
for CUL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CUL1 gene
- CUL32 CUL22 CUL4B2 CUL4A2 CUL52
5 SIMAP similar genes for CUL1 using alignment to 2 protein entries: CUL1_HUMAN (see all proteins):CUL2 CUL3 CUL4A CUL4B CUL5
CUL1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CUL1
PGOHUM00000235391
|
Genomic Variants
for CUL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CUL1 (148395006 - 148498202 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CUL1
1 CNV: 70072
1 Indel: 47260 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for CUL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CUL1 for disorders About GeneDecksing
OMIM gene information: 603134
OMIM disorders: --
20/21  diseases for CUL1 (see all 21): About MalaCardsdiffuse large b-cell lymphoma b-cell lymphomas xeroderma pigmentosum parkinson's disease
myxoma pituitary tumor rheumatoid arthritis ovarian cancer
hepatitis b vaccinia liver disease arthritis
gastric cancer colorectal cancer prostate cancer hepatitis
prostatitis melanoma malaria neuronitis
4 Novoseek disease relationships for CUL1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| parkinson disease |
22.3 |
3 |
19748892 (1), 19240248 (1) |
| cancer lung |
0 |
2 |
19349673 (1) |
| tumors |
0 |
1 |
19679553 (1) |
| cancer |
0 |
1 |
19679553 (1) |
Human Genome Epidemiology (HuGE) Navigator: CUL1 (2 documents)
Export disorders for CUL1 gene to outside databases
|
Publications
for CUL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CUL1 gene, integrated from 9 sources (see all 314):
(articles sorted by number of sources associating them with CUL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. (PubMed id 8681378)1, 2, 3 Kipreos E.T.... Hedgecock E.M. (1996)
- CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex. (PubMed id 12504026)1, 2, 9 Zheng J.... Zhang H. (2002)
- Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha. (PubMed id 10713156)1, 2, 9 Read M.A....Palombella V.J. (2000)
- Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A. (PubMed id 9663463)1, 2, 9 Michel J.J. and Xiong Y. (1998)
- Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha. (PubMed id 10230406)1, 2, 9 Tan P.... Pan Z.-Q. (1999)
- Covalent modification of all members of human cullin family proteins by NEDD8. (PubMed id 10597293)1, 2, 9 Hori T.... Tanaka K. (1999)
- Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germination: chip profiling implicates its role in cell cycle regulation. (PubMed id 10851089)1, 2, 9 Swaroop M....Sun Y. (2000)
- A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases. (PubMed id 20190741)1, 2 Gastaldello S.... Masucci M.G. (2010)
- Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. (PubMed id 18203720)1, 2 Glenn K.A.... Paulson H.L. (2008)
- Characterization of cullin-based E3 ubiquitin ligases in intact mammalian cells -- evidence for cullin dimerization. (PubMed id 17254749)1, 2 Chew E.H.... Hagen T. (2007)
|
External Searches for CUL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CUL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CUL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CUL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CUL1 gene:
Search GeneIP for patents involving CUL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CUL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for CUL1 | | OriGene shRNA RFP for CUL1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CUL1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CUL1 | | | OriGene Protein Over-expression Lysate for CUL1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CUL1 | | OriGene 3'-UTR Clone for CUL1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CUL1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CUL1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CUL1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CUL1 | | OriGene Custom Protein Services for CUL1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CUL1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CUL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CUL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CUL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CUL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CUL1 |
| |
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| | Antibodies & Assays for CUL1 |
| | | | Search Tocris compounds for CUL1 |
| |  |  |  |  | | | | | | Recombinant Protein for CUL1 |
|
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUL1 |
|  |  |  | | | | ThermoFisher Antibodies for CUL1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUL1 |
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