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Aliases for CUL1 Gene

Aliases for CUL1 Gene

  • Cullin 1 2 3
  • CUL-1 3 4
  • Cullin-1 3

External Ids for CUL1 Gene

Summaries for CUL1 Gene

GeneCards Summary for CUL1 Gene

CUL1 (Cullin 1) is a Protein Coding gene. Among its related pathways are PI-3K cascade and Signaling by GPCR. GO annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is CUL3.

UniProtKB/Swiss-Prot for CUL1 Gene

  • Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at Lys-21 and Lys-22; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) direct ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2.

Gene Wiki entry for CUL1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUL1 Gene

Genomics for CUL1 Gene

Genomic Location for CUL1 Gene

Start:
148,697,914 bp from pter
End:
148,801,110 bp from pter
Size:
103,197 bases
Orientation:
Plus strand

Genomic View for CUL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CUL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUL1 Gene

Regulatory Elements for CUL1 Gene

Proteins for CUL1 Gene

  • Protein details for CUL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13616-CUL1_HUMAN
    Recommended name:
    Cullin-1
    Protein Accession:
    Q13616
    Secondary Accessions:
    • D3DWG3
    • O60719
    • Q08AL6
    • Q8IYW1

    Protein attributes for CUL1 Gene

    Size:
    776 amino acids
    Molecular mass:
    89679 Da
    Quaternary structure:
    • Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit. Component of the SCF(FBXW11) complex containing FBXW11. Component of the SCF(SKP2) complex containing SKP2, in which it interacts directly with SKP1, SKP2 and RBX1. Component of the SCF(FBXW2) complex containing FBXw2. Component of the SCF(FBXO32) complex containing FBXO32. Component of the probable SCF(FBXO7) complex containing FBXO7. Component of the SCF(FBXO10) complex containing FBXO10. Component of the SCF(FBXO11) complex containing FBXO11. Component of the SCF(FBXO25) complex containing FBXO25. Component of the SCF(FBXO33) complex containing FBXO33. Component of the probable SCF(FBXO4) complex containing FBXO4. Component of the SCF(FBXO44) complex, composed of SKP1, CUL1 and FBXO44. Component of the SCF(BTRC) complex, composed of SKP1, CUL1 and BTRC. This complex binds phosphorylated NFKBIA. Part of a SCF complex consisting of CUL1, RBX1, SKP1 and FBXO2. Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Component of the SCF(FBXO17) complex, composed of SKP1, CUL1 and FBXO17. Component of the SCF(FBXO27) complex, composed of SKP1, CUL1 and FBXO27. Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF. Component of the SCF(FBXL3) complex composed of CUL1, SKP1, RBX1 and FBXL3. Component of the SCF(FBXL21) complex composed of CUL1, SKP1, RBX1 and FBXL21. Component of the SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Component of the SCF(FBXW7) composed of CUL1, SKP1, RBX1 and FBXW7. Interacts with CHEK2; mediates CHEK2 ubiquitination and regulates its function. Part of a complex with TIP120A/CAND1 and RBX1. The unneddylated form interacts with TIP120A/CAND1 and the interaction mediates the exchange of the F-box substrate-specific subunit. Can self-associate. Interacts with FBXW8. Interacts with RNF7. Interacts with CUL7; the interaction seems to be mediated by FBXW8. Interacts with TRIM21. Interacts with COPS2. Interacts with Epstein-Barr virus BPLF1. Interacts with human adenovirus early E1A protein; this interaction inhibits RBX1-CUL1-dependent elongation reaction of ubiquitin chains by the SCF(FBXW7) complex. Interacts with DCUN1D3.

    Three dimensional structures from OCA and Proteopedia for CUL1 Gene

neXtProt entry for CUL1 Gene

Proteomics data for CUL1 Gene at MOPED

Post-translational modifications for CUL1 Gene

  • Neddylated; which enhances the ubiquitination activity of SCF and prevents binding of the inhibitor CAND1. Deneddylated via its interaction with the COP9 signalosome (CSN) complex. Deneddylated by Epstein-Barr virus BPLF1 leading to a S-phase-like environment that is required for efficient replication of the viral genome.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys131, Lys410, Lys464, Lys468, Lys708, and Lys769

Other Protein References for CUL1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CUL1 Gene

Domains for CUL1 Gene

UniProtKB/Swiss-Prot:

CUL1_HUMAN
Family:
  • Belongs to the cullin family.:
    • Q13616
genes like me logo Genes that share domains with CUL1: view

No data available for Gene Families for CUL1 Gene

Function for CUL1 Gene

Molecular function for CUL1 Gene

UniProtKB/Swiss-Prot Function: Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at Lys-21 and Lys-22; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) direct ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2.

Gene Ontology (GO) - Molecular Function for CUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11961546
GO:0031625 ubiquitin protein ligase binding IEA --
genes like me logo Genes that share ontologies with CUL1: view
genes like me logo Genes that share phenotypes with CUL1: view

Animal Models for CUL1 Gene

MGI Knock Outs for CUL1:

miRNA for CUL1 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CUL1 Gene

Localization for CUL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CUL1 Gene COMPARTMENTS Subcellular localization image for CUL1 gene
Compartment Confidence
cytosol 4
nucleus 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0019005 SCF ubiquitin ligase complex ISS --
GO:0031461 cullin-RING ubiquitin ligase complex IDA 22405651
GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex IPI 12628165
genes like me logo Genes that share ontologies with CUL1: view

Pathways for CUL1 Gene

SuperPathways for CUL1 Gene

Superpath Contained pathways
1 Signaling by NOTCH1 PEST Domain Mutants in Cancer
2 CDK-mediated phosphorylation and removal of Cdc6
.78
3 Class I MHC mediated antigen processing and presentation
4 Cell cycle Role of SCF complex in cell cycle regulation
5 Regulation of PLK1 Activity at G2/M Transition
genes like me logo Genes that share pathways with CUL1: view

UniProtKB/Swiss-Prot Q13616-CUL1_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for CUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006511 ubiquitin-dependent protein catabolic process --
genes like me logo Genes that share ontologies with CUL1: view

Compounds for CUL1 Gene

(3) Novoseek inferred chemical compound relationships for CUL1 Gene

Compound -log(P) Hits PubMed IDs
cysteine 16.8 1
atp 0 1
oxygen 0 3
genes like me logo Genes that share compounds with CUL1: view

Transcripts for CUL1 Gene

Unigene Clusters for CUL1 Gene

Cullin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CUL1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^
SP1: - - - - -
SP2: -
SP3:
SP4: - - - - - - - -
SP5: - - - - - - -
SP6: - - - - -
SP7: - - - -
SP8: -
SP9:
SP10: - - - - - - - - - -
SP11: - - - - - -
SP12:
SP13:
SP14:
SP15: -
SP16:
SP17:

ExUns: 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c ^ 27a · 27b ^ 28a · 28b
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - -
SP10:
SP11:
SP12: -
SP13:
SP14: -
SP15:
SP16:
SP17:

Relevant External Links for CUL1 Gene

GeneLoc Exon Structure for
CUL1
ECgene alternative splicing isoforms for
CUL1

Expression for CUL1 Gene

mRNA expression in normal human tissues for CUL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CUL1 Gene

SOURCE GeneReport for Unigene cluster for CUL1 Gene Hs.146806

mRNA Expression by UniProt/SwissProt for CUL1 Gene

Q13616-CUL1_HUMAN
Tissue specificity: Expressed in lung fibroblasts.
genes like me logo Genes that share expressions with CUL1: view

Orthologs for CUL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CUL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CUL1 36
  • 99.61 (n)
  • 100 (a)
CUL1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CUL1 36
  • 89.13 (n)
  • 99.74 (a)
CUL1 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CUL1 36
  • 90.42 (n)
  • 99.74 (a)
CUL1 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cul1 36
  • 91.19 (n)
  • 99.87 (a)
Cul1 16
Cul1 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CUL1 37
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CUL1 37
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cul1 36
  • 90.76 (n)
  • 99.87 (a)
chicken
(Gallus gallus)
Aves CUL1 36
  • 83.85 (n)
  • 99.87 (a)
CUL1 37
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CUL1 37
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23826 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cul1 36
  • 82.86 (n)
  • 98.97 (a)
Str.6235 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14110 36
zebrafish
(Danio rerio)
Actinopterygii cul1a 37
  • 97 (a)
OneToMany
cul1b 36
  • 78.44 (n)
  • 94.05 (a)
cul1b 37
  • 94 (a)
OneToMany
wufc13a10 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008007 36
  • 64.47 (n)
  • 72.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta lin19 36
  • 59.85 (n)
  • 65.37 (a)
lin19 37
  • 63 (a)
OneToOne
CG11261 38
  • 25 (a)
lin19 38
  • 62 (a)
worm
(Caenorhabditis elegans)
Secernentea cul-1 36
  • 52.85 (n)
  • 47.28 (a)
cul-1 37
  • 46 (a)
OneToMany
cul-6 37
  • 37 (a)
OneToMany
cul-1 38
  • 46 (a)
cul-6 38
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC53 37
  • 31 (a)
OneToMany
CDC53 39
bread mold
(Neurospora crassa)
Ascomycetes NCU05204 36
  • 53.41 (n)
  • 51.26 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cul1 36
  • 50.57 (n)
  • 43.96 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13631 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 72 (a)
OneToOne
Species with no ortholog for CUL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CUL1 Gene

ENSEMBL:
Gene Tree for CUL1 (if available)
TreeFam:
Gene Tree for CUL1 (if available)

Paralogs for CUL1 Gene

Paralogs for CUL1 Gene

Selected SIMAP similar genes for CUL1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CUL1 Gene

genes like me logo Genes that share paralogs with CUL1: view

Variants for CUL1 Gene

Sequence variations from dbSNP and Humsavar for CUL1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs122571 -- 148,697,503(+) ATAGA(A/G)GGATC upstream-variant-2KB
rs243477 -- 148,759,062(-) TGTTG(A/G)AAACA intron-variant
rs243478 -- 148,757,676(-) aaaac(A/G)gacta intron-variant
rs243479 -- 148,756,520(-) GTCTC(C/T)ACTAA intron-variant
rs243480 -- 148,755,813(-) AACCG(G/T)ATCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CUL1 Gene

Variant ID Type Subtype PubMed ID
esv21729 CNV Loss 19812545
nsv518186 CNV Loss 19592680
esv2735325 CNV Deletion 23290073
esv2386698 CNV Deletion 18987734
esv2671538 CNV Deletion 23128226
esv2735326 CNV Deletion 23290073
nsv528653 CNV Loss 19592680
nsv465194 CNV Gain 19166990
nsv522305 CNV Loss 19592680

Relevant External Links for CUL1 Gene

HapMap Linkage Disequilibrium report
CUL1

Disorders for CUL1 Gene

(4) Novoseek inferred disease relationships for CUL1 Gene

Disease -log(P) Hits PubMed IDs
parkinson disease 22.3 2
cancer lung 0 1
tumors 0 1
cancer 0 1

Relevant External Links for CUL1

Genetic Association Database (GAD)
CUL1
Human Genome Epidemiology (HuGE) Navigator
CUL1
genes like me logo Genes that share disorders with CUL1: view

No data available for UniProtKB/Swiss-Prot for CUL1 Gene

Publications for CUL1 Gene

  1. Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A. (PMID: 9663463) Michel J.J. … Xiong Y. (Cell Growth Differ. 1998) 3 4 23
  2. Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha. (PMID: 10230406) Tan P. … Pan Z.-Q. (Mol. Cell 1999) 3 4 23
  3. Covalent modification of all members of human cullin family proteins by NEDD8. (PMID: 10597293) Hori T. … Tanaka K. (Oncogene 1999) 3 4 23
  4. Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha. (PMID: 10713156) Read M.A. … Palombella V.J. (Mol. Cell. Biol. 2000) 3 4 23
  5. Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germination: chip profiling implicates its role in cell cycle regulation. (PMID: 10851089) Swaroop M. … Sun Y. (Oncogene 2000) 3 4 23

Products for CUL1 Gene

  • Addgene plasmids for CUL1

Sources for CUL1 Gene

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