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CUL1 Gene

protein-coding   GIFtS: 68
GCID: GC07P148395

Cullin 1

  See CUL1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cullin 11 2
CUL-12 3
cullin-12

External Ids:    HGNC: 25511   Entrez Gene: 84542   Ensembl: ENSG000000551307   OMIM: 6031345   UniProtKB: Q136163   

Export aliases for CUL1 gene to outside databases

Previous GC identifers: GC07P146673 GC07P147710 GC07P147787 GC07P147833 GC07P148026 GC07P142474


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CUL1 Gene:
CUL1 (cullin 1) is a protein-coding gene. Diseases associated with CUL1 include glomuvenous malformation. GO annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is CUL3.

UniProtKB/Swiss-Prot: CUL1_HUMAN, Q13616
Function: Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase
complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction
and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1
subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.
The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and
exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the
SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct
ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated
NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2.
SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S
transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC
and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and
probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1.
SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1)
directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the
ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to
translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110.
SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) direct ubiquitination of TTI1 and
TELO2

Gene Wiki entry for CUL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CUL1 gene promoter:
         FOXO3   FOXO3a   FOXO1a   MyoD   FOXO3b   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): CUL1 promoter sequence
   Search Chromatin IP Primers for CUL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CUL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q36.1

CUL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CUL1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P148395:  view genomic region     (about GC identifiers)

Start:
148,395,006 bp from pter      End:
148,498,202 bp from pter
Size:
103,197 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 147,733,888-147,836,155     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CUL1_HUMAN, Q13616 (See protein sequence)
Recommended Name: Cullin-1  
Size: 776 amino acids; 89679 Da
Subunit: Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1,
RBX1 and a variable F-box domain-containing protein as substrate-specific subunit. Component of the SCF(FBXW11)
complex containing FBXW11. Component of the SCF(SKP2) complex containing SKP2, in which it interacts directly
with SKP1, SKP2 and RBX1. Component of the SCF(FBXW2) complex containing FBXw2. Component of the SCF(FBXO32)
complex containing FBXO32. Component of the probable SCF(FBXO7) complex containing FBXO7. Component of the
SCF(FBXO11) complex containing FBXO11. Component of the SCF(FBXO25) complex containing FBXO25. Component of the
SCF(FBXO33) complex containing FBXO33. Component of the probable SCF(FBXO4) complex containing FBXO4. Component
of the SCF(FBXO44) complex, composed of SKP1, CUL1 and FBXO44. Component of the SCF(BTRC) complex, composed of
SKP1, CUL1 and BTRC. This complex binds phosphorylated NFKBIA. Part of a SCF complex consisting of CUL1, RBX1,
SKP1 and FBXO2. Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Component of the
SCF(FBXO17) complex, composed of SKP1, CUL1 and FBXO17. Component of the SCF(FBXO27) complex, composed of SKP1,
CUL1 and FBXO27. Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF. Component of the
SCF(FBXL3) complex composed of CUL1, SKP1, RBX1 and FBXL3. Component of the SCF(FBXL21) complex composed of CUL1,
SKP1, RBX1 and FBXL21. Component of the SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Component of the
SCF(FBXW7) composed of CUL1, SKP1, RBX1 and FBXW7. Interacts with CHEK2; mediates CHEK2 ubiquitination and
regulates its function. Part of a complex with TIP120A/CAND1 and RBX1. The unneddylated form interacts with
TIP120A/CAND1 and the interaction mediates the exchange of the F-box substrate-specific subunit. Can
self-associate. Interacts with FBXW8. Interacts with RNF7. Interacts with CUL7; the interaction seems to be
mediated by FBXW8. Interacts with TRIM21. Interacts with COPS2. Interacts with Epstein-Barr virus BPLF1.
Interacts with human adenovirus early E1A protein; this interaction inhibits RBX1-CUL1-dependent elongation
reaction of ubiquitin chains by the SCF(FBXW7) complex
Selected PDB 3D structures from and Proteopedia for CUL1 (see all 7):
1LDJ (3D)        1LDK (3D)        1U6G (3D)        3RTR (3D)        3TDU (3D)        3TDZ (3D)    
Secondary accessions: D3DWG3 O60719 Q08AL6 Q8IYW1

Explore the universe of human proteins at neXtProt for CUL1: NX_Q13616

Explore proteomics data for CUL1 at MOPED

Post-translational modifications: 

  • Neddylated; which enhances the ubiquitination activity of SCF and prevents binding of the inhibitor CAND1.
    Deneddylated via its interaction with the COP9 signalosome (CSN) complex. Deneddylated by Epstein-Barr virus
    BPLF1 leading to a S-phase-like environment that is required for efficient replication of the viral genome1
  • Ubiquitination2 at Lys131, Lys410, Lys464, Lys468, Lys708, Lys769
  • Modification sites at PhosphoSitePlus

  • See CUL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003583.2  
    ENSEMBL proteins: 
     ENSP00000387160   ENSP00000473318   ENSP00000326804  
    Reactome Protein details: Q13616

    CUL1 Human Recombinant Protein Products:

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    Novus Biologicals CUL1 Proteins
    Novus Biologicals CUL1 Lysate
    Browse Sino Biological Recombinant Proteins
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    ProSpec Recombinant Protein for CUL1
    Cloud-Clone Corp. Proteins for CUL1

     
    Search eBioscience for Proteins for CUL1 

     
    antibodies-online proteins for CUL1 (8 products) 

     
    antibodies-online peptides for CUL1

    CUL1 Antibody Products:

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    antibodies-online antibodies for CUL1 (86 products) 

    CUL1 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR016159 Cullin_repeat-like_dom
     IPR019559 Cullin_neddylation_domain
     IPR016157 Cullin_CS
     IPR001373 Cullin_N
     IPR011991 WHTH_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q13616

    ProtoNet protein and cluster: Q13616

    1 Blocks protein domain: IPB001373 Cullin

    UniProtKB/Swiss-Prot: CUL1_HUMAN, Q13616
    Similarity: Belongs to the cullin family


    Find genes that share domains with CUL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CUL1_HUMAN, Q13616
    Function: Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase
    complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction
    and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1
    subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.
    The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and
    exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the
    SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct
    ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated
    NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2.
    SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S
    transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC
    and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and
    probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1.
    SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1)
    directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the
    ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to
    translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110.
    SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) direct ubiquitination of TTI1 and
    TELO2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11961546
    GO:0031625ubiquitin protein ligase binding IEA--
         
    Find genes that share ontologies with CUL1           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for CUL1:
     Decreased nuclei size in G2M  Increased G2M DNA content  Increased cell death in HCT116  Increased cell death in breast 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cul1):
     cellular  embryogenesis  growth/size/body  mortality/aging  other 

    Find genes that share phenotypes with CUL1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CUL1: Cul1tmTye Cul1tm1Rsjo

       genOway: Develop your customized and physiologically relevant rodent model for CUL1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CUL1:
    hsa-mir-100-5p (MIRT048506), hsa-mir-27a-3p (MIRT050028), hsa-let-7b-5p (MIRT032428), hsa-mir-27b-3p (MIRT046199)

    Block miRNA regulation of human, mouse, rat CUL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CUL1 (see all 13):
    hsa-miR-203 hsa-miR-4324 hsa-miR-300 hsa-miR-381 hsa-let-7a-2* hsa-miR-1284 hsa-miR-544b hsa-miR-493*
    SwitchGear 3'UTR luciferase reporter plasmidCUL1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CUL1
    Predesigned siRNA for gene silencing in human, mouse, rat CUL1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CUL1

    Clone
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    OriGene ORF clones in mouse, rat for CUL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CUL1 (NM_003592)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CUL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUL1
    Addgene plasmids for CUL1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    cytoskeleton1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0019005SCF ubiquitin ligase complex ISS--
    GO:0031461cullin-RING ubiquitin ligase complex IDA--

    Find genes that share ontologies with CUL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CUL1 About   (see all 36)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    2Parkin-Ubiquitin Proteasomal System pathway
    Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway0.89
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    4Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.79
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 in Cancer0.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH10.79
    NOTCH1 Intracellular Domain Regulates Transcription0.68
    5CDK-mediated phosphorylation and removal of Cdc6
    APC/C-mediated degradation of cell cycle proteins0.94
    Cyclin E associated events during G1/S transition0.86
    Regulation of mitotic cell cycle0.94
    Cyclin A-Cdk2-associated events at S phase entry0.85
    Regulation of APC/C activators between G1/S and early anaphase0.94
    S Phase0.78
    SCF-beta-TrCP mediated degradation of Emi10.91
    Activation of NF-kappaB in B Cells0.74


    Find genes that share SuperPaths with CUL1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CUL1
        Protein Stability

    Selected GeneGo (Thomson Reuters) Pathways for CUL1 (see all 7)
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Cell cycle ESR1 regulation of G1/S transition
    Cell cycle Regulation of G1/S transition (part 1)
    Proteolysis Putative ubiquitin pathway
    Cell cycle Role of SCF complex in cell cycle regulation

    Selected BioSystems Pathways for CUL1 (see all 8)
        Parkin-Ubiquitin Proteasomal System pathway
    TGF-beta Receptor Signaling Pathway
    Wnt Signaling Pathway NetPath
    Delta-Notch Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway

    Selected Reactome Pathways for CUL1 (see all 13)
        NOTCH1 Intracellular Domain Regulates Transcription
    SCF(Skp2)-mediated degradation of p27/p21
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
    SCF-beta-TrCP mediated degradation of Emi1


    Selected Kegg Pathways  (Kegg details for CUL1) (see all 8):
        Cell cycle
    Oocyte meiosis
    Ubiquitin mediated proteolysis
    Protein processing in endoplasmic reticulum
    Wnt signaling pathway

    UniProtKB/Swiss-Prot: CUL1_HUMAN, Q13616
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CUL1: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Cell Cycle in human mouse rat
              Apoptosis 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CUL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CUL1 (Q136161, 2, 3 ENSP000003268044) via UniProtKB, MINT, STRING, and/or I2D (see all 1186)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKP1P632081, 2, 3, ENSP000002314874EBI-359390,EBI-307486 MINT-4304038 MINT-7305060 MINT-8399460 MINT-7305000 MINT-6804066 MINT-6540206 MINT-8198846 I2D: score=19 STRING: ENSP00000231487
    RBX1P628771, 2, 3, ENSP000002162254EBI-359390,EBI-398523 MINT-24857 MINT-17422 MINT-6804066 MINT-6540206 MINT-8198846 I2D: score=15 STRING: ENSP00000216225
    BTRCQ9Y2971, 2, 3, ENSP000003592064EBI-359390,EBI-307461 MINT-4544675 MINT-14454 MINT-49909 I2D: score=8 STRING: ENSP00000359206
    CAND1Q86VP61, 2, 3EBI-359390,EBI-456077 MINT-4304052 MINT-7945693 I2D: score=7 
    COPS5Q929052, 3, ENSP000003505124MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000350512
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006511ubiquitin-dependent protein catabolic process ----
    GO:0006513protein monoubiquitination IEA--

    Find genes that share ontologies with CUL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CUL1

    3 Novoseek inferred chemical compound relationships for CUL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 16.8 1 17914462 (1)
    atp 0 1 12504026 (1)
    oxygen 0 1 19109186 (2), 19767563 (1)



    Find genes that share compounds with CUL1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CUL1 gene: 
    NM_003592.2  

    Unigene Cluster for CUL1:

    Cullin 1
    Hs.146806  [show with all ESTs]
    Unigene Representative Sequence: NM_003592
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409469 ENST00000602748 ENST00000325222(uc010lpg.3 uc003wey.3 uc003wez.3 uc003wfa.3)

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    hsa-miR-203 hsa-miR-4324 hsa-miR-300 hsa-miR-381 hsa-let-7a-2* hsa-miR-1284 hsa-miR-544b hsa-miR-493*
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    GenScript: all cDNA clones in your preferred vector: CUL1 (NM_003592)
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      QuantiFast Probe-based Assays in human, mouse, rat CUL1

    Additional mRNA sequence: 

    AF062536.1 AK096163.1 AK096505.1 AK296909.1 AK315023.1 BC032806.1 BC034318.1 BC125119.1 
    BC125120.1 BX537409.1 U58087.1 

    Selected DOTS entries (see all 27):

    DT.449164  DT.100657722  DT.100840125  DT.435047  DT.118924  DT.95239754  DT.100840129  DT.100027687 
    DT.121092222  DT.100840126  DT.100027686  DT.427987  DT.95290145  DT.80100128  DT.92447345  DT.95264535 
    DT.100840123  DT.121092220  DT.91839485  DT.92447333  DT.99938086  DT.425280  DT.92447339  DT.121092218 

    Selected AceView cDNA sequences (see all 449):

    BP374380 AL542914 AW296414 AI985805 AI559184 BG532186 AA361752 AW073848 
    AI186970 W80743 BG480605 AW337776 BM549512 CD724180 BQ009809 AW575487 
    BQ422405 BG548652 BM834457 CR617261 CR621639 AI298709 BQ228119 AU125503 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CUL1 (see all 17)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^
    SP1:                                                        -           -                                                           -     -                 -   
    SP2:                                                                                                                                                        -   
    SP3:                                                                                                                                                            
    SP4:                    -     -     -     -     -     -     -           -                                                                                       
    SP5:                          -     -     -     -     -     -           -                                                                                       

    ExUns: 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c ^ 27a · 27b ^ 28a · 28b
    SP1:  -     -                       -                                   -           -                 -           -           -               
    SP2:  -     -                       -                                   -           -                 -           -           -               
    SP3:                                -                                                                                                         
    SP4:                                                                                                                                          
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for CUL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CUL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAACCTGCTA
    CUL1 Expression
    About this image


    CUL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
    CUL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CUL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.146806

    UniProtKB/Swiss-Prot: CUL1_HUMAN, Q13616
    Tissue specificity: Expressed in lung fibroblasts

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CUL1: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Cell Cycle in human mouse rat
              Apoptosis 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CUL1 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cul11 , 5 cullin 11, 5 91.19(n)1
    99.87(a)1
      6 (22.90 cM)5
    269651  NM_012042.31  NP_036172.11 
     474533985 
    chicken
    (Gallus gallus)
    Aves CUL11 cullin 1 83.85(n)
    99.87(a)
      420783  XM_418878.4  XP_418878.3 
    lizard
    (Anolis carolinensis)
    Reptilia CUL16
    cullin 1
    89(a)
    1 ↔ 1
    6(53299772-53334634)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.238262 Xenopus laevis transcribed sequence with moderate similarity more 82.19(n)    CA791386.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc13a102 wufc13a10 81.95(n)   323883  BC045445.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta lin191 , 3 lin-19-like1 62(a)
    (best of 2)3
    59.85(n)1
    65.37(a)1
      357421  NM_165570.21  NP_724622.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cul-11 , 3 Cuticlin family3
    cul-11
    46(a)
    (best of 2)3
    52.85(n)1
    47.28(a)1
      III(10542891-10546537)3
    1764661  NM_066908.41  NP_499309.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC53(YDL132W)4 Cullin, structural protein of SCF complexes (which more   --   4(224304-226751) 851424  NP_010150.1 


    ENSEMBL Gene Tree for CUL1 (if available)
    TreeFam Gene Tree for CUL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for CUL1 gene
    CUL32  CUL4A2  CUL4B2  CUL22  CUL52  
    5 SIMAP similar genes for CUL1 using alignment to 2 protein entries:     CUL1_HUMAN (see all proteins):
    CUL2    CUL3    CUL4A    CUL4B    CUL5

    Find genes that share paralogs with CUL1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CUL1
    PGOHUM00000235391


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for CUL1 (see all 2198)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1151484281,2
    F--148393983(+) GTGGAC/GGTAAA 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1425272411,2
    C--148394188(+) TTCTAC/TTCAGC 1 -- us2k10--------
    rs1468370711,2
    C--148394223(+) CTATAA/TTGAAT 1 -- us2k10--------
    rs1393266111,2
    --148394254(+) GTTAGC/GGAATA 1 -- us2k10--------
    rs1406246011,2
    C--148394318(+) GGACAG/TTTTTT 1 -- us2k10--------
    rs1887310071,2
    --148394405(+) GTGCTC/GACAAA 1 -- us2k10--------
    rs1159443821,2
    F--148394458(+) AAGTGT/CAGGAT 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1503928931,2
    --148394552(+) TACTTC/GTAGAG 1 -- us2k10--------
    rs2016740501,2
    --148394594(+) AATAG-/AAGGAT 1 -- us2k10--------
    rs1225711,2
    C,F,O,A,H--148394595(+) ATAGAG/AGGATC 1 -- us2k126Minor allele frequency- A:0.39NA EA MN NS WA CSA 3614

    HapMap Linkage Disequilibrium report for CUL1 (148395006 - 148498202 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CUL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671538CNV Deletion23128226
    esv2735326CNV Deletion23290073
    esv2735325CNV Deletion23290073
    esv2386698CNV Deletion18987734
    nsv522305CNV Loss19592680
    esv21729CNV Loss19812545
    nsv528653CNV Loss19592680
    nsv518186CNV Loss19592680
    nsv465194CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 603134    OMIM disorders: --

    1 disease for CUL1:    
    About MalaCards
    glomuvenous malformation


    Find genes that share disorders with CUL1           About GenesLikeMe

    4 Novoseek inferred disease relationships for CUL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease 22.3 3 19748892 (1), 19240248 (1)
    cancer lung 0 2 19349673 (1)
    tumors 0 1 19679553 (1)
    cancer 0 1 19679553 (1)

    Genetic Association Database (GAD): CUL1
    Human Genome Epidemiology (HuGE) Navigator: CUL1 (2 documents)

    Export disorders for CUL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for CUL1 gene, integrated from 10 sources (see all 349):
    (articles sorted by number of sources associating them with CUL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. (PubMed id 8681378)1, 2, 3 Kipreos E.T.... Hedgecock E.M. (Cell 1996)
    2. CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex. (PubMed id 12504026)1, 2, 9 Zheng J.... Zhang H. (Mol. Cell 2002)
    3. Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha. (PubMed id 10713156)1, 2, 9 Read M.A....Palombella V.J. (Mol. Cell. Biol. 2000)
    4. Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A. (PubMed id 9663463)1, 2, 9 Michel J.J. and Xiong Y. (Cell Growth Differ. 1998)
    5. Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha. (PubMed id 10230406)1, 2, 9 Tan P.... Pan Z.-Q. (Mol. Cell 1999)
    6. Covalent modification of all members of human cullin family proteins by NEDD8. (PubMed id 10597293)1, 2, 9 Hori T.... Tanaka K. (Oncogene 1999)
    7. Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germination: chip profiling implicates its role in cell cycle regulation. (PubMed id 10851089)1, 2, 9 Swaroop M....Sun Y. (Oncogene 2000)
    8. FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas. (PubMed id 22113614)1, 2 Duan S....Pagano M. (Nature 2012)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    10. A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases. (PubMed id 20190741)1, 2 Gastaldello S.... Masucci M.G. (Nat. Cell Biol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8454 HGNC: 2551 AceView: CUL1 Ensembl:ENSG00000055130 euGenes: HUgn8454
    ECgene: CUL1 Kegg: 8454 H-InvDB: CUL1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CUL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CUL1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CUL1 gene:
    Search GeneIP for patents involving CUL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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