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Aliases for CUL1 Gene

Aliases for CUL1 Gene

  • Cullin 1 2 3 5
  • CUL-1 3 4
  • Cullin-1 3

External Ids for CUL1 Gene

Previous GeneCards Identifiers for CUL1 Gene

  • GC07P146673
  • GC07P147710
  • GC07P147787
  • GC07P147833
  • GC07P148026
  • GC07P148395
  • GC07P142474

Summaries for CUL1 Gene

GeneCards Summary for CUL1 Gene

CUL1 (Cullin 1) is a Protein Coding gene. Diseases associated with CUL1 include Xeroderma Pigmentosum Group E and Parkinson Disease 15, Autosomal Recessive. Among its related pathways are IL-1 signaling pathway and Notch signaling pathway (KEGG). GO annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is CUL2.

UniProtKB/Swiss-Prot for CUL1 Gene

  • Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(BTRC) and/or SCF(FBXW11) direct ubiquitination of CEP68 (PubMed:25704143, PubMed:25503564). SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at Lys-21 and Lys-22; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2.

Gene Wiki entry for CUL1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUL1 Gene

Genomics for CUL1 Gene

Regulatory Elements for CUL1 Gene

Enhancers for CUL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G148581 0.6 FANTOM5 18.5 -116.1 -116074 0.3 CTCF RAD21 CUL1 RPL32P17 GC07P148581 C7orf33
GH07G148579 0.6 FANTOM5 16.3 -118.3 -118322 0.2 RFX1 POLR2A SMC3 EP300 RAD21 CUL1 RPL32P17 GC07P148581 GC07M148530
GH07G148620 1.1 FANTOM5 ENCODE 6.5 -76.9 -76899 1.0 ELF3 THRB RAD21 RARA YY1 FOS PPARG NR2F2 CEBPA GLIS1 CUL1 EZH2 GC07P148623 GC07P148604
GH07G148771 1.2 Ensembl ENCODE 5.5 +75.1 75118 2.8 SIN3A FEZF1 ZNF2 ZNF121 FOS ZNF263 SP3 TSHZ1 ZNF488 ZNF610 CUL1 GC07M148769 RNU7-20P
GH07G148625 0.6 ENCODE 10.8 -72.4 -72391 0.2 PKNOX1 ZBTB21 PRDM6 GLIS1 ZNF24 WT1 TRIM28 SP7 C7orf33 CUL1 RPL32P17 LOC105375557 GC07P148623
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CUL1 on UCSC Golden Path with GeneCards custom track

Promoters for CUL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000219538 1286 3201 PKNOX1 ARNT CREB3L1 AGO1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1

Genomic Location for CUL1 Gene

Chromosome:
7
Start:
148,697,914 bp from pter
End:
148,801,110 bp from pter
Size:
103,197 bases
Orientation:
Plus strand

Genomic View for CUL1 Gene

Genes around CUL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CUL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CUL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUL1 Gene

Proteins for CUL1 Gene

  • Protein details for CUL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13616-CUL1_HUMAN
    Recommended name:
    Cullin-1
    Protein Accession:
    Q13616
    Secondary Accessions:
    • D3DWG3
    • O60719
    • Q08AL6
    • Q8IYW1

    Protein attributes for CUL1 Gene

    Size:
    776 amino acids
    Molecular mass:
    89679 Da
    Quaternary structure:
    • Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit. Component of the SCF(FBXW11) complex containing FBXW11. Component of the SCF(SKP2) complex containing SKP2, in which it interacts directly with SKP1, SKP2 and RBX1. Component of the SCF(FBXW2) complex containing FBXW2. Component of the SCF(FBXO32) complex containing FBXO32. Component of the probable SCF(FBXO7) complex containing FBXO7. Component of the SCF(FBXO10) complex containing FBXO10. Component of the SCF(FBXO11) complex containing FBXO11. Component of the SCF(FBXO25) complex containing FBXO25. Component of the SCF(FBXO33) complex containing FBXO33. Component of the probable SCF(FBXO4) complex containing FBXO4. Component of the SCF(FBXO44) complex, composed of SKP1, CUL1 and FBXO44. Component of the SCF(BTRC) complex, composed of SKP1, CUL1 and BTRC. This complex binds phosphorylated NFKBIA. Part of a SCF complex consisting of CUL1, RBX1, SKP1 and FBXO2. Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Component of the SCF(FBXO17) complex, composed of SKP1, CUL1 and FBXO17. Component of the SCF(FBXO27) complex, composed of SKP1, CUL1 and FBXO27. Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF. Component of the SCF(FBXL3) complex composed of CUL1, SKP1, RBX1 and FBXL3. Component of the SCF(FBXL21) complex composed of CUL1, SKP1, RBX1 and FBXL21. Component of the SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Component of the SCF(FBXW7) composed of CUL1, SKP1, RBX1 and FBXW7. Interacts with CHEK2; mediates CHEK2 ubiquitination and regulates its function. Part of a complex with TIP120A/CAND1 and RBX1. The unneddylated form interacts with TIP120A/CAND1 and the interaction mediates the exchange of the F-box substrate-specific subunit. Can self-associate. Interacts with FBXW8. Interacts with RNF7. Interacts with CUL7; the interaction seems to be mediated by FBXW8. Interacts with TRIM21. Interacts with COPS2. Interacts with DCUN1D3. Interacts with CEP68 as part of the SCF(FBXW11) complex; the interaction is probably mediated by FBXW11 and the complex also contains CDK5RAP2 and PCNT (PubMed:25503564). Interacts (when neddylated) with ARIH1; leading to activate the E3 ligase activity of ARIH1 (PubMed:24076655, PubMed:27565346). Interacts with COPS9 isoform 2 (PubMed:23776465).
    • (Microbial infection) Interacts with Epstein-Barr virus BPLF1. Interacts with human adenovirus early E1A protein; this interaction inhibits RBX1-CUL1-dependent elongation reaction of ubiquitin chains by the SCF(FBXW7) complex.

    Three dimensional structures from OCA and Proteopedia for CUL1 Gene

neXtProt entry for CUL1 Gene

Post-translational modifications for CUL1 Gene

  • (Microbial infection) Deneddylated by Epstein-Barr virus BPLF1 leading to a S-phase-like environment that is required for efficient replication of the viral genome (PubMed:20190741).
  • Neddylated; which enhances the ubiquitination activity of SCF and prevents binding of the inhibitor CAND1. Deneddylated via its interaction with the COP9 signalosome (CSN) complex (PubMed:10597293, PubMed:10713156, PubMed:15537541, PubMed:18805092).
  • Ubiquitination at isoforms=131, Lys410, isoforms=464, isoforms=468, isoforms=708, and Lys769
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CUL1 (CUL1)

No data available for DME Specific Peptides for CUL1 Gene

Domains & Families for CUL1 Gene

Gene Families for CUL1 Gene

Suggested Antigen Peptide Sequences for CUL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13616

UniProtKB/Swiss-Prot:

CUL1_HUMAN :
  • Belongs to the cullin family.
Family:
  • Belongs to the cullin family.
genes like me logo Genes that share domains with CUL1: view

Function for CUL1 Gene

Molecular function for CUL1 Gene

UniProtKB/Swiss-Prot Function:
Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(BTRC) and/or SCF(FBXW11) direct ubiquitination of CEP68 (PubMed:25704143, PubMed:25503564). SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at Lys-21 and Lys-22; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2.

Gene Ontology (GO) - Molecular Function for CUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 11961546
GO:0031625 ubiquitin protein ligase binding IBA,IEA --
GO:0061630 contributes_to ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with CUL1: view
genes like me logo Genes that share phenotypes with CUL1: view

Animal Models for CUL1 Gene

MGI Knock Outs for CUL1:

Animal Model Products

CRISPR Products

miRNA for CUL1 Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CUL1
  • Applied Biological Materials Clones for CUL1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CUL1 Gene

Localization for CUL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CUL1 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0019005 SCF ubiquitin ligase complex ISS --
GO:0031461 cullin-RING ubiquitin ligase complex IEA,IDA 22405651
GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex IPI 12628165
genes like me logo Genes that share ontologies with CUL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CUL1 Gene

Pathways & Interactions for CUL1 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 CDK-mediated phosphorylation and removal of Cdc6
.78
3 Signaling by NOTCH1
4 Cell cycle Role of SCF complex in cell cycle regulation
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with CUL1: view

UniProtKB/Swiss-Prot Q13616-CUL1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for CUL1 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for CUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS 8681378
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
genes like me logo Genes that share ontologies with CUL1: view

Drugs & Compounds for CUL1 Gene

(3) Drugs for CUL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CUL1: view

Transcripts for CUL1 Gene

Unigene Clusters for CUL1 Gene

Cullin 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CUL1
  • Applied Biological Materials Clones for CUL1

Alternative Splicing Database (ASD) splice patterns (SP) for CUL1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^
SP1: - - - - -
SP2: -
SP3:
SP4: - - - - - - - -
SP5: - - - - - - -
SP6: - - - - -
SP7: - - - -
SP8: -
SP9:
SP10: - - - - - - - - - -
SP11: - - - - - -
SP12:
SP13:
SP14:
SP15: -
SP16:
SP17:

ExUns: 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c ^ 27a · 27b ^ 28a · 28b
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - -
SP10:
SP11:
SP12: -
SP13:
SP14: -
SP15:
SP16:
SP17:

Relevant External Links for CUL1 Gene

GeneLoc Exon Structure for
CUL1
ECgene alternative splicing isoforms for
CUL1

Expression for CUL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CUL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CUL1 Gene

This gene is overexpressed in Lymph node (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CUL1 Gene



Protein tissue co-expression partners for CUL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CUL1 Gene:

CUL1

SOURCE GeneReport for Unigene cluster for CUL1 Gene:

Hs.146806

mRNA Expression by UniProt/SwissProt for CUL1 Gene:

Q13616-CUL1_HUMAN
Tissue specificity: Expressed in lung fibroblasts.

Evidence on tissue expression from TISSUES for CUL1 Gene

  • Nervous system(4.5)
  • Liver(4.3)
  • Lung(2.4)
  • Muscle(2.3)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with CUL1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CUL1 Gene

Orthologs for CUL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CUL1 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia CUL1 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CUL1 34 35
  • 99.61 (n)
oppossum
(Monodelphis domestica)
Mammalia CUL1 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cul1 34 16 35
  • 91.19 (n)
rat
(Rattus norvegicus)
Mammalia Cul1 34
  • 90.76 (n)
dog
(Canis familiaris)
Mammalia CUL1 34 35
  • 90.42 (n)
cow
(Bos Taurus)
Mammalia CUL1 34 35
  • 89.13 (n)
chicken
(Gallus gallus)
Aves CUL1 34 35
  • 83.85 (n)
lizard
(Anolis carolinensis)
Reptilia CUL1 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cul1 34
  • 82.86 (n)
Str.6235 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.23826 34
zebrafish
(Danio rerio)
Actinopterygii cul1a 35
  • 97 (a)
OneToMany
cul1b 34 35
  • 78.44 (n)
wufc13a10 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14110 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008007 34
  • 64.47 (n)
fruit fly
(Drosophila melanogaster)
Insecta lin19 36 34 35
  • 59.85 (n)
CG11261 36
  • 25 (a)
worm
(Caenorhabditis elegans)
Secernentea cul-1 36 34 35
  • 52.85 (n)
cul-6 36 35
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC53 35 37
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 72 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU05204 34
  • 53.41 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cul1 34
  • 50.57 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13631 34
Species where no ortholog for CUL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CUL1 Gene

ENSEMBL:
Gene Tree for CUL1 (if available)
TreeFam:
Gene Tree for CUL1 (if available)

Paralogs for CUL1 Gene

Paralogs for CUL1 Gene

(5) SIMAP similar genes for CUL1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CUL1 Gene

genes like me logo Genes that share paralogs with CUL1: view

Variants for CUL1 Gene

Sequence variations from dbSNP and Humsavar for CUL1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000035239 -- 148,702,938(+) TGGAA(A/G)TCTTT intron-variant
rs1000099201 -- 148,742,238(+) GACTG(A/G)GTAAT intron-variant
rs1000153860 -- 148,736,875(+) CATCA(A/G)CACAT intron-variant
rs1000187366 -- 148,698,144(+) GCAGG(C/T)GGTAA upstream-variant-2KB
rs1000206601 -- 148,737,102(+) CTATT(A/G)AAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CUL1 Gene

Variant ID Type Subtype PubMed ID
esv21729 CNV loss 19812545
esv2386698 CNV deletion 18987734
esv2671538 CNV deletion 23128226
esv2735325 CNV deletion 23290073
esv2735326 CNV deletion 23290073
nsv1119145 CNV deletion 24896259
nsv465194 CNV gain 19166990
nsv518186 CNV loss 19592680
nsv522305 CNV loss 19592680
nsv528653 CNV loss 19592680
nsv608972 CNV gain 21841781
nsv958422 CNV deletion 24416366

Variation tolerance for CUL1 Gene

Residual Variation Intolerance Score: 9.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CUL1 Gene

Human Gene Mutation Database (HGMD)
CUL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CUL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CUL1 Gene

Disorders for CUL1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CUL1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
xeroderma pigmentosum group e
  • xeroderma pigmentosum v
parkinson disease 15, autosomal recessive
  • autosomal recessive early-onset parkinson disease 15
- elite association - COSMIC cancer census association via MalaCards
Search CUL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CUL1

Genetic Association Database (GAD)
CUL1
Human Genome Epidemiology (HuGE) Navigator
CUL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CUL1
genes like me logo Genes that share disorders with CUL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CUL1 Gene

Publications for CUL1 Gene

  1. CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex. (PMID: 12504026) Zheng J. … Zhang H. (Mol. Cell 2002) 3 4 22 64
  2. Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha. (PMID: 10713156) Read M.A. … Palombella V.J. (Mol. Cell. Biol. 2000) 3 4 22 64
  3. Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germination: chip profiling implicates its role in cell cycle regulation. (PMID: 10851089) Swaroop M. … Sun Y. (Oncogene 2000) 3 4 22 64
  4. Covalent modification of all members of human cullin family proteins by NEDD8. (PMID: 10597293) Hori T. … Tanaka K. (Oncogene 1999) 3 4 22 64
  5. Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha. (PMID: 10230406) Tan P. … Pan Z.-Q. (Mol. Cell 1999) 3 4 22 64

Products for CUL1 Gene

  • Addgene plasmids for CUL1

Sources for CUL1 Gene

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