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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CUL1 Gene

protein-coding   GIFtS: 67
GCID: GC07P148395

Cullin 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cullin 11 2
CUL-12 3
cullin-12

External Ids:    HGNC: 25511   Entrez Gene: 84542   Ensembl: ENSG000000551307   OMIM: 6031345   UniProtKB: Q136163   

Export aliases for CUL1 gene to outside databases

Previous GC identifers: GC07P146673 GC07P147710 GC07P147787 GC07P147833 GC07P148026 GC07P142474


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CUL1 Gene: 
CUL1 (cullin 1) is a protein-coding gene. Diseases associated with CUL1 include glomuvenous malformation, and polyploidy, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway. GO annotations related to this gene include protein binding and ubiquitin protein ligase binding. An important paralog of this gene is CUL3.

UniProtKB/Swiss-Prot: CUL1_HUMAN, Q13616
Function: Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase
complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction
and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1
subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.
The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and
exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the
SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct
ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated
NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2.
SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S
transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC
and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and
probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1.
SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11)
does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and
'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate
transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of
CRY1 and CRY2. SCF(FBXO9) direct ubiquitination of TTI1 and TELO2

Gene Wiki entry for CUL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007914.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CUL1 gene promoter:
         FOXO3   FOXO3a   FOXO1a   MyoD   FOXO3b   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): CUL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CUL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CUL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q36.1

CUL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CUL1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P148395:  view genomic region     (about GC identifiers)

Start:
148,395,006 bp from pter      End:
148,498,202 bp from pter
Size:
103,197 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 147,733,888-147,836,155     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CUL1_HUMAN, Q13616 (See protein sequence)
Recommended Name: Cullin-1  
Size: 776 amino acids; 89679 Da
Subunit: Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1,
RBX1 and a variable F-box domain-containing protein as substrate-specific subunit. Component of the SCF(FBXW11)
complex containing FBXW11. Component of the SCF(SKP2) complex containing SKP2, in which it interacts directly
with SKP1, SKP2 and RBX1. Component of the SCF(FBXW2) complex containing FBXw2. Component of the SCF(FBXO32)
complex containing FBXO32. Component of the probable SCF(FBXO7) complex containing FBXO7. Component of the
SCF(FBXO11) complex containing FBXO11. Component of the SCF(FBXO25) complex containing FBXO25. Component of the
SCF(FBXO33) complex containing FBXO33. Component of the probable SCF(FBXO4) complex containing FBXO4. Component
of the SCF(FBXO44) complex, composed of SKP1, CUL1 and FBXO44. Component of the SCF(BTRC) complex, composed of
SKP1, CUL1 and BTRC. This complex binds phosphorylated NFKBIA. Part of a SCF complex consisting of CUL1, RBX1,
SKP1 and FBXO2. Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Component of the
SCF(FBXO17) complex, composed of SKP1, CUL1 and FBXO17. Component of the SCF(FBXO27) complex, composed of SKP1,
CUL1 and FBXO27. Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF. Component of the
SCF(FBXL3) complex composed of CUL1, SKP1, RBX1 and FBXL3. Component of the SCF(FBXL21) complex composed of CUL1,
SKP1, RBX1 and FBXL21. Component of the SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Component of the
SCF(FBXW7) composed of CUL1, SKP1, RBX1 and FBXW7. Interacts with CHEK2; mediates CHEK2 ubiquitination and
regulates its function. Part of a complex with TIP120A/CAND1 and RBX1. The unneddylated form interacts with
TIP120A/CAND1 and the interaction mediates the exchange of the F-box substrate-specific subunit. Can
self-associate. Interacts with FBXW8. Interacts with RNF7. Interacts with CUL7; the interaction seems to be
mediated by FBXW8. Interacts with TRIM21. Interacts with COPS2. Interacts with Epstein-Barr virus BPLF1.
Interacts with human adenovirus early E1A protein; this interaction inhibits RBX1-CUL1-dependent elongation
reaction of ubiquitin chains by the SCF(FBXW7) complex
6/7 PDB 3D structures from and Proteopedia for CUL1 (see all 7):
1LDJ (3D)        1LDK (3D)        1U6G (3D)        3RTR (3D)        3TDU (3D)        3TDZ (3D)    
Secondary accessions: D3DWG3 O60719 Q08AL6 Q8IYW1

Explore the universe of human proteins at neXtProt for CUL1: NX_Q13616

Explore proteomics data for CUL1 at MOPED 

Post-translational modifications:

  • UniProtKB: Neddylated; which enhances the ubiquitination activity of SCF. Deneddylated via its interaction with the COP9
    signalosome (CSN) complex. Deneddylated by Epstein-Barr virus BPLF1 leading to a S-phase-like environment that is
    required for efficient replication of the viral genome
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13616

  • CUL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CUL1 Protein Expression
    REFSEQ proteins: NP_003583.2  
    ENSEMBL proteins: 
     ENSP00000387160   ENSP00000473318   ENSP00000326804  
    Reactome Protein details: Q13616
    Human Recombinant Protein Products for CUL1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CUL1
    OriGene Protein Over-expression Lysate for CUL1
    OriGene MassSpec for CUL1 
    OriGene Custom Protein Services for CUL1
    GenScript Custom Purified and Recombinant Proteins Services for CUL1
    Novus Biologicals CUL1 Proteins
    Novus Biologicals CUL1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CUL1
    Cloud-Clone Corp. Proteins for CUL1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0019005SCF ubiquitin ligase complex ISS--
    GO:0031461cullin-RING ubiquitin ligase complex IDA--

    CUL1 for ontologies           About GeneDecksing



    CUL1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CUL1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CUL1 
    OriGene Antibodies for CUL1
    OriGene Custom Antibody Services for CUL1
    GenScript Custom Superior Antibodies Services for CUL1
    Novus Biologicals CUL1 Antibodies
    Abcam antibodies for CUL1
    Cloud-Clone Corp. Antibodies for CUL1 
    ThermoFisher Antibodies for CUL1
    LSBio Antibodies in human, mouse, rat for CUL1 

    Assay Products for CUL1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CUL1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CUL1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CUL1 
    Cloud-Clone Corp. CLIAs for CUL1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR016159 Cullin_repeat-like_dom
     IPR019559 Cullin_neddylation_domain
     IPR016157 Cullin_CS
     IPR001373 Cullin_N
     IPR011991 WHTH_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q13616

    ProtoNet protein and cluster: Q13616

    1 Blocks protein domain: IPB001373 Cullin

    UniProtKB/Swiss-Prot: CUL1_HUMAN, Q13616
    Similarity: Belongs to the cullin family


    CUL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CUL1_HUMAN, Q13616
    Function: Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase
    complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction
    and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1
    subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.
    The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and
    exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the
    SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct
    ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated
    NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2.
    SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S
    transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC
    and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and
    probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1.
    SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11)
    does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and
    'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate
    transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of
    CRY1 and CRY2. SCF(FBXO9) direct ubiquitination of TTI1 and TELO2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11961546
    GO:0031625ubiquitin protein ligase binding IEA--
         
    CUL1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CUL1:
     Decreased nuclei size in G2M  Increased G2M DNA content  Increased cell death in HCT116  Increased cell death in breast 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cul1):
     cellular  embryogenesis  growth/size  mortality/aging  other 

    CUL1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CUL1: Cul1tmTye Cul1tm1Rsjo

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CUL1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CUL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CUL1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CUL1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CUL1
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate CUL1 (see all 13):
    hsa-miR-203 hsa-miR-4324 hsa-miR-300 hsa-miR-381 hsa-let-7a-2* hsa-miR-1284 hsa-miR-544b hsa-miR-493*
    SwitchGear 3'UTR luciferase reporter plasmidCUL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CUL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CUL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CUL1
    Sirion Biotech Customized adenovirus for overexpression of CUL1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CUL1 (see all 7)
    OriGene ORF clones in mouse, rat for CUL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CUL1 (NM_003592)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CUL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUL1
    Sirion Biotech Customized lentivirus for stable overexpression of CUL1 
                         Customized lentivirus expression plasmids for stable overexpression of CUL1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CUL1
    Search LifeMap BioReagents cell lines for CUL1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUL1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CUL1 About   (see all 35)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway0.93
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3Wnt signaling pathway
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    4Circadian Clock
    Circadian Clock0.40
    Circadian rhythm0.35
    5Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.89
    Signaling by NOTCH1 in Cancer0.79
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.89
    Signaling by NOTCH10.79
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH0.74

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/7 EMD Millipore Pathways for CUL1 (see all 7)
        Development Notch Signaling Pathway
    Cell cycle Regulation of G1/S transition (part 1)
    Cell cycle ESR1 regulation of G1/S transition
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Putative ubiquitin pathway


    1 Cell Signaling Technology (CST) Pathway for CUL1
        Protein Stability

    5/7 GeneGo (Thomson Reuters) Pathways for CUL1 (see all 7)
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Cell cycle ESR1 regulation of G1/S transition
    Cell cycle Regulation of G1/S transition (part 1)
    Proteolysis Putative ubiquitin pathway
    Cell cycle Role of SCF complex in cell cycle regulation

    5/8 BioSystems Pathways for CUL1 (see all 8)
        Parkin-Ubiquitin Proteasomal System pathway
    TGF-beta Receptor Signaling Pathway
    Wnt Signaling Pathway NetPath
    TNF-alpha/NF-kB Signaling Pathway
    Delta-Notch Signaling Pathway

    5/44        Reactome Pathways for CUL1 (see all 44)
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    NOTCH1 Intracellular Domain Regulates Transcription
    SCF-beta-TrCP mediated degradation of Emi1
    FBXW7 Mutants and NOTCH1 in Cancer
    Prolactin receptor signaling


    5/8         Kegg Pathways  (Kegg details for CUL1) (see all 8):
        Cell cycle
    Oocyte meiosis
    Ubiquitin mediated proteolysis
    Protein processing in endoplasmic reticulum
    Wnt signaling pathway

    UniProtKB/Swiss-Prot: CUL1_HUMAN, Q13616
    Pathway: Protein modification; protein ubiquitination


    CUL1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CUL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/1086 Interacting proteins for CUL1 (Q136161, 2, 3 ENSP000003268044) via UniProtKB, MINT, STRING, and/or I2D (see all 1086)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKP1P632081, 2, 3, ENSP000002314874EBI-359390,EBI-307486 MINT-4304038 MINT-7305060 MINT-8399460 MINT-7305000 MINT-6804066 MINT-6540206 MINT-8198846 I2D: score=19 STRING: ENSP00000231487
    RBX1P628771, 2, 3, ENSP000002162254EBI-359390,EBI-398523 MINT-24857 MINT-17422 MINT-6804066 MINT-6540206 MINT-8198846 I2D: score=15 STRING: ENSP00000216225
    CAND1Q86VP61, 2, 3EBI-359390,EBI-456077 MINT-4304052 MINT-7945693 I2D: score=7 
    BTRCQ9Y2972, 3, ENSP000003592064MINT-4544675 MINT-14454 MINT-49909 I2D: score=8 STRING: ENSP00000359206
    COPS5Q929052, 3, ENSP000003505124MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000350512
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006511ubiquitin-dependent protein catabolic process ----
    GO:0006513protein monoubiquitination IEA--
    GO:0006915apoptotic process ----

    CUL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CUL1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CUL1

    3 Novoseek inferred chemical compound relationships for CUL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 16.8 1 17914462 (1)
    atp 0 1 12504026 (1)
    oxygen 0 1 19109186 (2), 19767563 (1)

    Search CenterWatch for drugs/clinical trials and news about CUL1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CUL1 gene: 
    NM_003592.2  

    Unigene Cluster for CUL1:

    Cullin 1
    Hs.146806  [show with all ESTs]
    Unigene Representative Sequence: NM_003592
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409469 ENST00000602748 ENST00000325222(uc010lpg.3 uc003wey.3 uc003wez.3 uc003wfa.3)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate CUL1 (see all 13):
    hsa-miR-203 hsa-miR-4324 hsa-miR-300 hsa-miR-381 hsa-let-7a-2* hsa-miR-1284 hsa-miR-544b hsa-miR-493*
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    Additional mRNA sequence: 

    AF062536.1 AK096163.1 AK096505.1 AK296909.1 AK315023.1 BC032806.1 BC034318.1 BC125119.1 
    BC125120.1 BX537409.1 U58087.1 

    24/27 DOTS entries (see all 27):

    DT.449164  DT.100657722  DT.100840125  DT.435047  DT.118924  DT.95239754  DT.100840129  DT.100027687 
    DT.121092222  DT.100840126  DT.100027686  DT.427987  DT.95290145  DT.80100128  DT.92447345  DT.95264535 
    DT.100840123  DT.121092220  DT.91839485  DT.92447333  DT.99938086  DT.425280  DT.92447339  DT.121092218 

    24/449 AceView cDNA sequences (see all 449):

    BM927944 CB129145 BG548652 CD724180 BQ009809 AU125503 BG532186 Z44546 
    BQ228119 C04758 W80743 BM834457 BM549512 BQ052930 BQ422405 CB164375 
    BQ006765 BG480605 CR621639 AA281570 AA361899 BI858282 AA305185 AI378762 

    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for CUL1 (see all 17)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^
    SP1:                                                        -           -                                                           -     -                 -   
    SP2:                                                                                                                                                        -   
    SP3:                                                                                                                                                            
    SP4:                    -     -     -     -     -     -     -           -                                                                                       
    SP5:                          -     -     -     -     -     -           -                                                                                       

    ExUns: 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c ^ 27a · 27b ^ 28a · 28b
    SP1:  -     -                       -                                   -           -                 -           -           -               
    SP2:  -     -                       -                                   -           -                 -           -           -               
    SP3:                                -                                                                                                         
    SP4:                                                                                                                                          
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for CUL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CUL1 expression in normal human tissues (normalized intensities)      CUL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAACCTGCTA
    CUL1 Expression
    About this image


    CUL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
             testis ; cells in seminiferus ducts   
     
     Uterus
             cervix, uterine ; glandular cells   
     
     Epithelium (Reproductive System)    fully expand to see all 2 entries
             cervix, uterine ; squamous epithelial cells   
     
     Peripheral Nervous System (Nervous System)
             colon ; peripheral nerve/ganglion   

    See CUL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CUL1

    SOURCE GeneReport for Unigene cluster: Hs.146806

    UniProtKB/Swiss-Prot: CUL1_HUMAN, Q13616
    Tissue specificity: Expressed in lung fibroblasts

        SABiosciences Expression via Pathway-Focused PCR Arrays including CUL1: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Cell Cycle in human mouse rat
              Apoptosis 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CUL1 gene from 8/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cul11 , 5 cullin 11, 5 91.19(n)1
    99.87(a)1
      6 (22.90 cM)5
    269651  NM_012042.31  NP_036172.11 
     474533985 
    chicken
    (Gallus gallus)
    Aves CUL11 cullin 1 83.85(n)
    99.87(a)
      420783  XM_418878.3  XP_418878.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    88(a)
    100(a)
    1 ↔ many
    1 ↔ many
    6(53299772-53334634)
    AAWZ02039031(1286-9611)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.238262 Xenopus laevis transcribed sequence with moderate similarity more 82.19(n)    CA791386.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc13a102 wufc13a10 81.95(n)   323883  BC045445.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta lin191 , 3 lin-19-like1 62(a)
    (best of 2)3
    59.8(n)1
    65.37(a)1
      357421  NM_165571.21  NP_724623.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cul-11 , 3 Cuticlin family3
    Protein CUL-11
    46(a)
    (best of 2)3
    52.8(n)1
    47.42(a)1
      III(10542891-10546537)3
    1764661  NM_066908.31  NP_499309.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC53(YDL132W)4 Cullin, structural protein of SCF complexes (which more   --   4(224304-226751) 851424  NP_010150.1 


    ENSEMBL Gene Tree for CUL1 (if available)
    TreeFam Gene Tree for CUL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CUL1 gene
    CUL32  CUL4A2  CUL4B2  CUL22  CUL52  
    5 SIMAP similar genes for CUL1 using alignment to 2 protein entries:     CUL1_HUMAN (see all proteins):
    CUL2    CUL3    CUL4A    CUL4B    CUL5

    CUL1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CUL1
    PGOHUM00000235391


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2198 SNPs in CUL1 are shown (see all 2198)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1151484281,2
    F--148393983(+) GTGGAC/GGTAAA 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1425272411,2
    C--148394188(+) TTCTAC/TTCAGC 1 -- us2k10--------
    rs1468370711,2
    C--148394223(+) CTATAA/TTGAAT 1 -- us2k10--------
    rs1393266111,2
    --148394254(+) GTTAGC/GGAATA 1 -- us2k10--------
    rs1406246011,2
    C--148394318(+) GGACAG/TTTTTT 1 -- us2k10--------
    rs1887310071,2
    --148394405(+) GTGCTC/GACAAA 1 -- us2k10--------
    rs1159443821,2
    F--148394458(+) AAGTGT/CAGGAT 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1503928931,2
    --148394552(+) TACTTC/GTAGAG 1 -- us2k10--------
    rs2016740501,2
    --148394594(+) AATAG-/AAGGAT 1 -- us2k10--------
    rs1225711,2
    C,F,O,A,H--148394595(+) ATAGAG/AGGATC 1 -- us2k126Minor allele frequency- A:0.39NA EA MN NS WA CSA 3614

    HapMap Linkage Disequilibrium report for CUL1 (148395006 - 148498202 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CUL1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2671538CNV Deletion23128226
    esv2735326CNV Deletion23290073
    esv2735325CNV Deletion23290073
    esv2386698CNV Deletion18987734
    nsv522305CNV Loss19592680
    esv21729CNV Loss19812545
    nsv528653CNV Loss19592680
    nsv518186CNV Loss19592680
    nsv465194CNV Gain19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603134    OMIM disorders: --

    20/27 diseases for CUL1 (see all 27):    About MalaCards
    glomuvenous malformation    polyploidy    hepatitis e    xeroderma pigmentosum
    pituitary tumors    vaccinia    parkinson's disease    diffuse large b-cell lymphoma
    b-cell lymphomas    thyroid cancer    liver disease    multiple myeloma
    myeloma    rheumatoid arthritis    hepatitis b    arthritis
    gastric cancer    ovarian cancer    colorectal cancer    melanoma


    CUL1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for CUL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease 22.3 3 19748892 (1), 19240248 (1)
    cancer lung 0 2 19349673 (1)
    tumors 0 1 19679553 (1)
    cancer 0 1 19679553 (1)

    Genetic Association Database (GAD): CUL1
    Human Genome Epidemiology (HuGE) Navigator: CUL1 (2 documents)

    Export disorders for CUL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CUL1 gene, integrated from 9 sources (see all 342):
    (articles sorted by number of sources associating them with CUL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. (PubMed id 8681378)1, 2, 3 Kipreos E.T.... Hedgecock E.M. (1996)
    2. CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex. (PubMed id 12504026)1, 2, 9 Zheng J.... Zhang H. (2002)
    3. Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha. (PubMed id 10713156)1, 2, 9 Read M.A....Palombella V.J. (2000)
    4. Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A. (PubMed id 9663463)1, 2, 9 Michel J.J. and Xiong Y. (1998)
    5. Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha. (PubMed id 10230406)1, 2, 9 Tan P.... Pan Z.-Q. (1999)
    6. Covalent modification of all members of human cullin family proteins by NEDD8. (PubMed id 10597293)1, 2, 9 Hori T.... Tanaka K. (1999)
    7. Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germination: chip profiling implicates its role in cell cycle regulation. (PubMed id 10851089)1, 2, 9 Swaroop M....Sun Y. (2000)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    9. A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases. (PubMed id 20190741)1, 2 Gastaldello S.... Masucci M.G. (2010)
    10. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PubMed id 19738611)1, 4 Cunningham J.M....Fridley B.L. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8454 HGNC: 2551 AceView: CUL1 Ensembl:ENSG00000055130 euGenes: HUgn8454
    ECgene: CUL1 Kegg: 8454 H-InvDB: CUL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CUL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CUL1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CUL1 gene:
    Search GeneIP for patents involving CUL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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