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Aliases for CUEDC2 Gene

Aliases for CUEDC2 Gene

  • CUE Domain Containing 2 2 3 5
  • C10orf66 3 4
  • Chromosome 10 Open Reading Frame 66 2
  • CUE Domain-Containing Protein 2 3
  • BA18I14.5 3

External Ids for CUEDC2 Gene

Previous HGNC Symbols for CUEDC2 Gene

  • C10orf66

Previous GeneCards Identifiers for CUEDC2 Gene

  • GC10M103848
  • GC10M104172
  • GC10M097816
  • GC10M104184

Summaries for CUEDC2 Gene

GeneCards Summary for CUEDC2 Gene

CUEDC2 (CUE Domain Containing 2) is a Protein Coding gene. Among its related pathways are DNA Damage and Toll-like Receptor Signaling Pathway.

UniProtKB/Swiss-Prot for CUEDC2 Gene

  • Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUEDC2 Gene

Genomics for CUEDC2 Gene

Regulatory Elements for CUEDC2 Gene

Enhancers for CUEDC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G102595 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -168.0 -168005 11.2 FOXA2 MLX ARID4B DMAP1 ZNF2 YY1 ZNF766 ZNF143 FOS SP5 MFSD13A SFXN2 ACTR1A SUFU C10orf95 PSD FBXL15 CUEDC2 MIR146B ARL3
GH10G102467 1 Ensembl ENCODE 12 -36.2 -36209 2.7 HDAC1 KLF1 ZBTB40 ADNP ZNF600 NR2F1 ELF4 CEBPB ELF1 DPF2 MFSD13A MIR146B CUEDC2 SUFU NFKB2 RNU6-43P FBXL15 PSD ELOVL3 RPARP-AS1
GH10G102478 1 ENCODE 11.6 -46.6 -46562 0.9 PKNOX1 ATF1 CREB3L1 ARNT ARID4B SIN3A ZNF2 ZNF143 DEK ZNF263 MFSD13A SUFU MIR146B CUEDC2 RNU6-43P NFKB2 ELOVL3 ENSG00000273262 GC10P102474 PIR54211
GH10G102462 0.9 ENCODE 11.5 -30.9 -30886 1.6 HDAC1 HDGF TBP FOXA2 ARID4B ZNF48 RARA KAT2B YY1 SCRT2 MFSD13A MIR146B CUEDC2 FBXL15 PSD SUFU RNU6-43P NFKB2 ELOVL3 GC10P102468
GH10G102625 1.8 FANTOM5 Ensembl ENCODE dbSUPER 4.9 -198.1 -198055 10.6 ATF1 ZFP64 ARID4B YY1 GLIS2 GATA2 FOS NFYC REST MIER3 MFSD13A SFXN2 ACTR1A CUEDC2 GBF1 TRIM8 RNU6-43P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CUEDC2 on UCSC Golden Path with GeneCards custom track

Promoters for CUEDC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000032739 66 1201 HDGF CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for CUEDC2 Gene

Chromosome:
10
Start:
102,423,245 bp from pter
End:
102,432,666 bp from pter
Size:
9,422 bases
Orientation:
Minus strand

Genomic View for CUEDC2 Gene

Genes around CUEDC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CUEDC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CUEDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUEDC2 Gene

Proteins for CUEDC2 Gene

  • Protein details for CUEDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H467-CUED2_HUMAN
    Recommended name:
    CUE domain-containing protein 2
    Protein Accession:
    Q9H467
    Secondary Accessions:
    • D3DR88
    • Q9BWG8

    Protein attributes for CUEDC2 Gene

    Size:
    287 amino acids
    Molecular mass:
    32009 Da
    Quaternary structure:
    • Interacts with PGR. Interacts with ESR1 in the presence or absence of 17 beta-estradiol.
    SequenceCaution:
    • Sequence=AAH00262.1; Type=Erroneous termination; Positions=227; Note=Translated as Glu.; Evidence={ECO:0000305};

neXtProt entry for CUEDC2 Gene

Post-translational modifications for CUEDC2 Gene

  • Ubiquitination at Lys82, Lys186, isoforms=213, Lys219, isoforms=230, Lys256, isoforms=261, isoforms=272, and isoforms=279
  • Modification sites at PhosphoSitePlus

Other Protein References for CUEDC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CUEDC2 Gene

Domains & Families for CUEDC2 Gene

Protein Domains for CUEDC2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CUEDC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H467

UniProtKB/Swiss-Prot:

CUED2_HUMAN :
  • The CUE domain mediates interaction with PGR and ESR1.
  • Belongs to the CUEDC2 family.
Domain:
  • The CUE domain mediates interaction with PGR and ESR1.
Family:
  • Belongs to the CUEDC2 family.
genes like me logo Genes that share domains with CUEDC2: view

No data available for Gene Families for CUEDC2 Gene

Function for CUEDC2 Gene

Molecular function for CUEDC2 Gene

UniProtKB/Swiss-Prot Function:
Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.

Gene Ontology (GO) - Molecular Function for CUEDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17347654
genes like me logo Genes that share ontologies with CUEDC2: view
genes like me logo Genes that share phenotypes with CUEDC2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CUEDC2

CRISPR Products

miRNA for CUEDC2 Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CUEDC2 Gene

Localization for CUEDC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CUEDC2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CUEDC2 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CUEDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with CUEDC2: view

Pathways & Interactions for CUEDC2 Gene

genes like me logo Genes that share pathways with CUEDC2: view

Pathways by source for CUEDC2 Gene

1 Cell Signaling Technology pathway for CUEDC2 Gene
1 BioSystems pathway for CUEDC2 Gene

Gene Ontology (GO) - Biological Process for CUEDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010936 negative regulation of macrophage cytokine production IMP 24882011
GO:1900016 negative regulation of cytokine production involved in inflammatory response IMP 24882011
genes like me logo Genes that share ontologies with CUEDC2: view

No data available for SIGNOR curated interactions for CUEDC2 Gene

Drugs & Compounds for CUEDC2 Gene

No Compound Related Data Available

Transcripts for CUEDC2 Gene

Unigene Clusters for CUEDC2 Gene

CUE domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CUEDC2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - -
SP2: - -
SP3: - - -
SP4: -
SP5: -
SP6: - - -
SP7: -
SP8:

Relevant External Links for CUEDC2 Gene

GeneLoc Exon Structure for
CUEDC2
ECgene alternative splicing isoforms for
CUEDC2

Expression for CUEDC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CUEDC2 Gene

Protein differential expression in normal tissues from HIPED for CUEDC2 Gene

This gene is overexpressed in Bone (56.0) and Fetal Brain (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CUEDC2 Gene



NURSA nuclear receptor signaling pathways regulating expression of CUEDC2 Gene:

CUEDC2

SOURCE GeneReport for Unigene cluster for CUEDC2 Gene:

Hs.500874

mRNA Expression by UniProt/SwissProt for CUEDC2 Gene:

Q9H467-CUED2_HUMAN
Tissue specificity: Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared to high-grade tumors.

Evidence on tissue expression from TISSUES for CUEDC2 Gene

  • Eye(4.2)
  • Bone(4)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with CUEDC2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CUEDC2 Gene

Orthologs for CUEDC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CUEDC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CUEDC2 34 35
  • 99.88 (n)
dog
(Canis familiaris)
Mammalia CUEDC2 34 35
  • 93.01 (n)
cow
(Bos Taurus)
Mammalia CUEDC2 34 35
  • 92.11 (n)
rat
(Rattus norvegicus)
Mammalia Cuedc2 34
  • 88.64 (n)
mouse
(Mus musculus)
Mammalia Cuedc2 34 16 35
  • 88.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CUEDC2 35
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CUEDC2 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves CUEDC2 34 35
  • 62.86 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia cuedc2 34
  • 59.41 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398317 34
zebrafish
(Danio rerio)
Actinopterygii cuedc2 34 35
  • 55.19 (n)
wufi42e02 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001586 34
  • 48.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9636 34 35
  • 44.36 (n)
Species where no ortholog for CUEDC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CUEDC2 Gene

ENSEMBL:
Gene Tree for CUEDC2 (if available)
TreeFam:
Gene Tree for CUEDC2 (if available)

Paralogs for CUEDC2 Gene

No data available for Paralogs for CUEDC2 Gene

Variants for CUEDC2 Gene

Sequence variations from dbSNP and Humsavar for CUEDC2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000023936 -- 102,432,501(+) CCCTG(A/G)GCCGG intron-variant
rs1000056704 -- 102,432,142(+) AGGCA(C/T)CAAGG intron-variant
rs1000082882 -- 102,424,972(+) AAGGT(A/G)ACAGG intron-variant
rs1000102189 -- 102,429,751(+) CCTGG(A/G)CTGTC intron-variant
rs1000473105 -- 102,429,309(+) ATAAA(C/T)AGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CUEDC2 Gene

Variant ID Type Subtype PubMed ID
nsv1159761 CNV deletion 26073780
nsv951006 CNV deletion 24416366

Variation tolerance for CUEDC2 Gene

Residual Variation Intolerance Score: 33.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CUEDC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CUEDC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CUEDC2 Gene

Disorders for CUEDC2 Gene

UniProtKB/Swiss-Prot

CUED2_HUMAN
  • Note=May predict the clinical outcome of tamoxifen therapy of breast cancer patients. Patients with tumors that highly express CUEDC2 do not respond to tamoxifen treatment as effectively as those with tumors with low expression.

Relevant External Links for CUEDC2

Genetic Association Database (GAD)
CUEDC2
Human Genome Epidemiology (HuGE) Navigator
CUEDC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CUEDC2

No disorders were found for CUEDC2 Gene.

No data available for MalaCards and Genatlas for CUEDC2 Gene

Publications for CUEDC2 Gene

  1. CUEDC2 interacts with heat shock protein 70 and negatively regulates its chaperone activity. (PMID: 24685480) Gong L. … Chen L. (Biochem. Biophys. Res. Commun. 2014) 2 3 64
  2. Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer. (PMID: 21572428) Pan X. … Zhang X.M. (Nat. Med. 2011) 3 4 64
  3. CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasome. (PMID: 17347654) Zhang P.-J. … Zhang X.-M. (EMBO J. 2007) 3 4 64
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64

Products for CUEDC2 Gene

Sources for CUEDC2 Gene

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