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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CUEDC2 Gene

protein-coding   GIFtS: 49
GCID: GC10M104172

CUE domain containing 2

(Previous name: chromosome 10 open reading frame 66 )
(Previous symbol: C10orf66)
 Explore 2 diseases affiliated with
CUEDC2 via our new
 Human Malady Compendium 
Biological research products
for CUEDC2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
CUE Domain Containing 21 2
C10orf661 2 3
MGC24911
Chromosome 10 Open Reading Frame 661
BA18I14.51
CUE Domain-Containing Protein 22

External Ids:    HGNC: 283521   Entrez Gene: 790042   Ensembl: ENSG000001078747   OMIM: 6141425   UniProtKB: Q9H4673   

Export aliases for CUEDC2 gene to outside databases

Previous GC identifers: GC10M103848 GC10M097816


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CUED2_HUMAN, Q9H467
Function: Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence
of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through
a similar mechanism




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CUEDC2 gene promoter:
         USF1   p53   Tal-1   NRSF form 1   NRSF form 2   E47   COMP1   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCUEDC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CUEDC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CUEDC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.32   Ensembl cytogenetic band:  10q24.32   HGNC cytogenetic band: 10q24.32

CUEDC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CUEDC2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M104172:  view genomic region     (about GC identifiers)

Start:
104,183,002 bp from pter      End:
104,192,423 bp from pter
Size:
9,422 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CUED2_HUMAN, Q9H467 (See protein sequence)
Recommended Name: CUE domain-containing protein 2  
Size: 287 amino acids; 32009 Da
Subunit: Interacts with PGR. Interacts with ESR1 in the presence or absence of 17 beta-estradiol
Subcellular location: Cytoplasm. Nucleus
Sequence caution: Sequence=AAH00262.1; Type=Erroneous termination; Positions=227; Note=Translated as Glu;
Secondary accessions: D3DR88 Q9BWG8

Explore the universe of human proteins at neXtProt for CUEDC2: NX_Q9H467

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H467

  • CUEDC2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_076945.2  
    ENSEMBL proteins: 
     ENSP00000358953  

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    Uscn Proteins for CUEDC2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--


    CUEDC2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CUEDC2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR003892 CUE

    Graphical View of Domain Structure for InterPro Entry Q9H467

    ProtoNet protein and cluster: Q9H467

    1 Blocks protein family: IPB003892 Ubiquitin system component Cue

    UniProtKB/Swiss-Prot: CUED2_HUMAN, Q9H467
    Domain: The CUE domain mediates interaction with PGR and ESR1
    Similarity: Belongs to the CUEDC2 family
    Similarity: Contains 1 CUE domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CUED2_HUMAN, Q9H467
    Function: Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence
    of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through
    a similar mechanism

    miRNA
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    hsa-miR-642a hsa-miR-4318 hsa-miR-330-5p hsa-miR-450b-3p hsa-miR-4314 hsa-miR-326 hsa-miR-324-5p hsa-miR-892a
    SwitchGear 3'UTR luciferase reporter plasmidCUEDC2 3' UTR sequence
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17347654


    CUEDC2 for ontologies           About GeneDecksing


    Animal Models:
         1 MGI phenotypic allele for Cuedc2 (no phenotypes)

    CUEDC2 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CUEDC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/15 Interacting proteins for CUEDC2 (Q9H4671, 2, 3 ENSP000003589534) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PGRP064011, 2, 3, ENSP000003251204EBI-1248228,EBI-78539 MINT-4787932 MINT-4787991 MINT-4787971 MINT-4788009 MINT-4787894 MINT-4787873 MINT-4787953 I2D: score=4 STRING: ENSP00000325120
    ESR1P033721, 2, 3, ENSP000002062494EBI-1248228,EBI-78473 MINT-4788039 MINT-4788057 I2D: score=3 STRING: ENSP00000206249
    CHUKO151113, ENSP000003594244I2D: score=3 STRING: ENSP00000359424
    PPP1CAP621363, ENSP000003260314I2D: score=2 STRING: ENSP00000326031
    IKBKBO149203, ENSP000003391514I2D: score=3 STRING: ENSP00000339151
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CUEDC2
    Search CenterWatch for drugs/clinical trials and news about CUEDC2 / CUED2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CUEDC2 gene: 
    NM_024040.2  

    Unigene Cluster for CUEDC2:

    CUE domain containing 2
    Hs.500874  [show with all ESTs]
    Unigene Representative Sequence: AK094695
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000465409(uc001kvm.2) ENST00000369937(uc001kvn.2) ENST00000486762
    ENST00000477994

    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CUEDC2:
    hsa-miR-642a hsa-miR-4318 hsa-miR-330-5p hsa-miR-450b-3p hsa-miR-4314 hsa-miR-326 hsa-miR-324-5p hsa-miR-892a
    SwitchGear 3'UTR luciferase reporter plasmidCUEDC2 3' UTR sequence
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    Additional cDNA sequence: 

    AB025425.1 AB232358.1 AF086406.1 AK094695.1 BC000262.1 

    8 DOTS entries:

    DT.415694  DT.100777573  DT.99933063  DT.100780335  DT.100780337  DT.100780336  DT.92432604  DT.95200335 

    24/236 AceView cDNA sequences (see all 236):

    BM782365 BM452007 AL540797 AF086406 BG470650 BI518742 CR619733 AA363125 
    BU155827 BI771272 BQ933043 BF725312 BM562487 CD743077 BQ719075 AI381481 
    AA370462 AI086483 CR611545 AA532544 BU728292 BM129558 AA303129 AA652967 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CUEDC2 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:                          -                                   -                 -           -                           
    SP2:                          -                                   -                                                         
    SP3:                          -                                   -                 -                                       
    SP4:                                                              -                                                         
    SP5:                          -                                                                                             


    ECgene alternative splicing isoforms for CUEDC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CUEDC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCACAGTAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CUEDC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CUEDC2

    SOURCE GeneReport for Unigene cluster: Hs.500874

    UniProtKB/Swiss-Prot: CUED2_HUMAN, Q9H467
    Tissue specificity: Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues
    (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared
    to high-grade tumors

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CUEDC2 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cuedc21 , 5 CUE domain containing 21, 5 88.62(n)1
    88.03(a)1
      19 (38.81 cM)5
    671161  NM_024192.21  NP_077154.21 
     463298125 
    chicken
    (Gallus gallus)
    Aves CUEDC21 CUE domain containing 2 63.43(n)
    59.71(a)
      423761  XM_003641492.1  XP_003641540.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3983172 mitotic phosphoprotein 38 75.33(n)    AF419151.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi42e022 Danio rerio clone RK011A3A05 hypothetical protein MGC2491 more 72.39(n)    AY394932.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG96361 CG9636 43.91(n)
    29.89(a)
      40967  NM_141517.3  NP_649774.1 


    ENSEMBL Gene Tree for CUEDC2 (if available)
    TreeFam Gene Tree for CUEDC2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/158 NCBI SNPs in CUEDC2 are shown (see all 158    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1860429981,2
    --104182545(+) CTCACC/GCTGCT 2 -- int10--------
    rs1178780701,2
    C,F,--104182761(+) CTGCCA/TATCGG 2 -- int1 ut311Minor allele frequency- T:0.02NA 120
    rs1826749501,2
    --104182909(+) TGCTGC/GCCTGT 2 -- int10--------
    rs125581,2
    C,A--104183154(-) GCCTTC/TTAGGC 2 -- ut31 int1 ese33Minor allele frequency- T:0.00MN NA 188
    rs1489044551,2
    C,--104183176(+) CCGGCG/AAGTGC 2 -- ut31 int11Minor allele frequency- A:0.00EU 1323
    rs1435897221,2
    C,--104183385(+) ATTCCA/GCATCC 2 -- int10--------
    rs1381907491,2
    C,--104183389(+) CGCATC/TCCCAG 2 -- int10--------
    rs1855109131,2
    C,--104183392(+) ATCCCC/GAGCAA 2 -- int10--------
    rs2007450801,2
    --104183441(+) TGAATC/TTTCTG 2 K syn10--------
    rs1119109061,2
    C--104183475(+) TGTACC/G/TTGTCA 1 -- spa11CSA 1

    HapMap Linkage Disequilibrium report for CUEDC2 (104183002 - 104192423 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CUEDC2: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CUEDC2 for disorders           About GeneDecksing

    OMIM gene information: 614142    OMIM disorders: --

    UniProtKB/Swiss-Prot: CUED2_HUMAN, Q9H467
  • Note=May predict the clinical outcome of tamoxifen therapy of breast cancer patients. Patients with tumors
  • that highly express CUEDC2 do not respond to tamoxifen treatment as effectively as those with tumors with low
    expression

    2 diseases for CUEDC2:    About MalaCards
    alzheimer's disease    breast cancer

    Human Genome Epidemiology (HuGE) Navigator: CUEDC2 (1 document)

    Export disorders for CUEDC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CUEDC2 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with CUEDC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer. (PubMed id 21572428)1, 2 Pan X.... Zhang X.M. (2011)
    2. CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasome. (PubMed id 17347654)1, 2 Zhang P.-J....Zhang X.-M. (2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    6. CUEDC2 (CUE domain-containing 2) and SOCS3 (suppressor s of cytokine signaling 3) cooperate to negatively regulate Janus kinase 1/signa l transducers and activators of transcription 3 signaling. (PubMed id 22084247)1 Zhang W.N....Li H.Y. (2012)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79004 HGNC: 28352 AceView: CUEDC2 Ensembl:ENSG00000107874 euGenes: HUgn79004
    ECgene: CUEDC2 H-InvDB: CUEDC2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CUEDC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CUEDC2 gene:
    Search GeneIP for patents involving CUEDC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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