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CUEDC2 Gene

protein-coding   GIFtS: 54
GCID: GC10M104184

CUE Domain Containing 2

(Previous name: chromosome 10 open reading frame 66)
(Previous symbol: C10orf66)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CUE Domain Containing 21 2
C10orf661 2 3
Chromosome 10 Open Reading Frame 661
bA18I14.52
CUE Domain-Containing Protein 22

External Ids:    HGNC: 283521   Entrez Gene: 790042   Ensembl: ENSG000001078747   OMIM: 6141425   UniProtKB: Q9H4673   

Export aliases for CUEDC2 gene to outside databases

Previous GC identifers: GC10M103848 GC10M104172 GC10M097816


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CUEDC2 Gene:
CUEDC2 (CUE domain containing 2) is a protein-coding gene. Diseases associated with CUEDC2 include alzheimer's disease, and malaria.

UniProtKB/Swiss-Prot: CUED2_HUMAN, Q9H467
Function: Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the
presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein
levels through a similar mechanism




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CUEDC2 gene promoter:
         USF1   p53   Tal-1   NRSF form 1   NRSF form 2   E47   COMP1   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCUEDC2 promoter sequence
   Search Chromatin IP Primers for CUEDC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CUEDC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.32   Ensembl cytogenetic band:  10q24.32   HGNC cytogenetic band: 10q24.32

CUEDC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CUEDC2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M104184:  view genomic region     (about GC identifiers)

Start:
104,183,002 bp from pter      End:
104,192,423 bp from pter
Size:
9,422 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CUED2_HUMAN, Q9H467 (See protein sequence)
Recommended Name: CUE domain-containing protein 2  
Size: 287 amino acids; 32009 Da
Subunit: Interacts with PGR. Interacts with ESR1 in the presence or absence of 17 beta-estradiol
Sequence caution: Sequence=AAH00262.1; Type=Erroneous termination; Positions=227; Note=Translated as Glu;
Secondary accessions: D3DR88 Q9BWG8

Explore the universe of human proteins at neXtProt for CUEDC2: NX_Q9H467

Explore proteomics data for CUEDC2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys82, Lys186, Lys213, Lys219, Lys230, Lys256, Lys261, Lys272, Lys279
  • Modification sites at PhosphoSitePlus

  • See CUEDC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_076945.2  
    ENSEMBL proteins: 
     ENSP00000358953  

    CUEDC2 Human Recombinant Protein Products:

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    Novus Biologicals CUEDC2 Proteins
    Novus Biologicals CUEDC2 Lysate
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    ProSpec Recombinant Protein for CUEDC2
    Cloud-Clone Corp. Proteins for CUEDC2

    CUEDC2 Antibody Products:

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    CUEDC2 Assay Products:

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    Cloud-Clone Corp. ELISAs for CUEDC2
    Cloud-Clone Corp. CLIAs for CUEDC2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003892 CUE

    Graphical View of Domain Structure for InterPro Entry Q9H467

    ProtoNet protein and cluster: Q9H467

    1 Blocks protein domain: IPB003892 Ubiquitin system component Cue

    UniProtKB/Swiss-Prot: CUED2_HUMAN, Q9H467
    Domain: The CUE domain mediates interaction with PGR and ESR1
    Similarity: Belongs to the CUEDC2 family
    Similarity: Contains 1 CUE domain


    CUEDC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CUED2_HUMAN, Q9H467
    Function: Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the
    presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein
    levels through a similar mechanism

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17347654
         
    CUEDC2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Cuedc2 (no phenotypes)

    CUEDC2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CUEDC2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CUEDC2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CUEDC2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CUEDC2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CUEDC2:
    hsa-mir-331-3p (MIRT043568), hsa-mir-615-3p (MIRT039666), hsa-mir-186-5p (MIRT045300), hsa-mir-324-5p (MIRT043183)

    Block miRNA regulation of human, mouse, rat CUEDC2 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate CUEDC2:
    hsa-miR-642a hsa-miR-4318 hsa-miR-330-5p hsa-miR-450b-3p hsa-miR-4314 hsa-miR-326 hsa-miR-324-5p hsa-miR-892a
    SwitchGear 3'UTR luciferase reporter plasmidCUEDC2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CUEDC2
    Predesigned siRNA for gene silencing in human, mouse, rat CUEDC2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CUEDC2

    Clone
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    OriGene ORF clones in mouse, rat for CUEDC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CUEDC2 (NM_024040)
    Sino Biological Human cDNA Clone for CUEDC2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CUEDC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUEDC2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CUEDC2
    Browse ESI BIO Cell Lines and PureStem Progenitors for CUEDC2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUEDC2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CUED2_HUMAN, Q9H467: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0031965nuclear membrane IDA--

    CUEDC2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CUEDC2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CUEDC2
        Cell Cycle / Checkpoint Control




    CUEDC2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CUEDC2
    Interactions:

        GeneGlobe Interaction Network for CUEDC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for CUEDC2 (Q9H4671, 2, 3 ENSP000003589534) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PGRP064011, 2, 3, ENSP000003251204EBI-1248228,EBI-78539 MINT-4787932 MINT-4787991 MINT-4787971 MINT-4788009 MINT-4787894 MINT-4787873 MINT-4787953 I2D: score=4 STRING: ENSP00000325120
    ESR1P033721, 2, 3, ENSP000002062494EBI-1248228,EBI-78473 MINT-4788039 MINT-4788057 I2D: score=3 STRING: ENSP00000206249
    CHUKO151113, ENSP000003594244I2D: score=3 STRING: ENSP00000359424
    PPP1CAP621363, ENSP000003260314I2D: score=2 STRING: ENSP00000326031
    IKBKBO149203, ENSP000003391514I2D: score=3 STRING: ENSP00000339151
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CUEDC2 (CUED2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CUEDC2 gene: 
    NM_024040.2  

    Unigene Cluster for CUEDC2:

    CUE domain containing 2
    Hs.500874  [show with all ESTs]
    Unigene Representative Sequence: AK094695
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000465409(uc001kvm.2) ENST00000369937(uc001kvn.2) ENST00000486762
    ENST00000477994

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CUEDC2 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate CUEDC2:
    hsa-miR-642a hsa-miR-4318 hsa-miR-330-5p hsa-miR-450b-3p hsa-miR-4314 hsa-miR-326 hsa-miR-324-5p hsa-miR-892a
    SwitchGear 3'UTR luciferase reporter plasmidCUEDC2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CUEDC2
    Predesigned siRNA for gene silencing in human, mouse, rat CUEDC2
    Clone
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    OriGene clones in human, mouse for CUEDC2 (see all 7)
    OriGene ORF clones in mouse, rat for CUEDC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CUEDC2 (NM_024040)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CUEDC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUEDC2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CUEDC2
    OriGene qSTAR qPCR primer pairs in human, mouse for CUEDC2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CUEDC2
      QuantiTect SYBR Green Assays in human, mouse, rat CUEDC2
      QuantiFast Probe-based Assays in human, mouse, rat CUEDC2

    Additional mRNA sequence: 

    AB025425.1 AB232358.1 AF086406.1 AK094695.1 BC000262.1 

    8 DOTS entries:

    DT.415694  DT.100777573  DT.99933063  DT.100780335  DT.100780337  DT.100780336  DT.92432604  DT.95200335 

    Selected AceView cDNA sequences (see all 236):

    CR619733 BM782365 CA502914 BG470650 BQ018603 AI381481 CR626050 AW248805 
    CR592558 AA370462 BM706980 BE253754 BM452007 AA363125 BI518742 BU155827 
    BQ677260 AW082846 BQ933043 BF725312 BM562487 BM824750 BM457768 BG912022 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CUEDC2 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:                          -                                   -                 -           -                           
    SP2:                          -                                   -                                                         
    SP3:                          -                                   -                 -                                       
    SP4:                                                              -                                                         
    SP5:                          -                                                                                             


    ECgene alternative splicing isoforms for CUEDC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CUEDC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCACAGTAA
    CUEDC2 Expression
    About this image

    CUEDC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CUEDC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.500874

    UniProtKB/Swiss-Prot: CUED2_HUMAN, Q9H467
    Tissue specificity: Significantly up-regulated in breast tumor tissues compared with matched adjacent normal
    tissues (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade
    tumors compared to high-grade tumors

        Custom PCR Arrays for CUEDC2
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    QuantiFast Probe-based Assays in human, mouse, rat CUEDC2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUEDC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CUEDC2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cuedc21 , 5 CUE domain containing 21, 5 88.62(n)1
    88.03(a)1
      19 (38.81 cM)5
    671161  NM_024192.21  NP_077154.21 
     463298125 
    chicken
    (Gallus gallus)
    Aves CUEDC21 CUE domain containing 2 62.86(n)
    58.57(a)
      423761  NM_001277349.1  NP_001264278.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3983172 mitotic phosphoprotein 38 75.33(n)    AF419151.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi42e022 Danio rerio clone RK011A3A05 hypothetical protein MGC2491 more 72.39(n)    AY394932.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG96361 CG9636 44.36(n)
    30.8(a)
      40967  NM_141517.3  NP_649774.1 


    ENSEMBL Gene Tree for CUEDC2 (if available)
    TreeFam Gene Tree for CUEDC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CUEDC2 (see all 198)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2007450801,2
    --104183441(+) TGAATC/TTTCTG 2 K syn10--------
    rs1119109061,2
    C--104183475(+) TGTACC/G/TTGTCA 1 -- spa11CSA 1
    rs32109271,2
    C,H--104183563(-) TTCATC/TCTGCA 2 I syn14Minor allele frequency- T:0.12MN NS NA 414
    rs1908098671,2
    C--104183604(+) GAGGCA/GTCTGG 2 R C mis10--------
    rs2022422641,2
    C--104183639(+) CTGGTC/TTAGGC 1 -- int11Minor allele frequency- T:0.00EU 1179
    rs2011235071,2
    --104183731(+) ATGGTA/GGAGGG 1 -- int10--------
    rs2000605631,2
    C--104183832(+) CCCCCC/TGAGCT 2 Q R mis10--------
    rs2016544461,2
    C--104183927(+) TCAGCG/ACCAGT 2 /G syn11Minor allele frequency- A:0.00EU 1237
    rs2016684601,2
    C--104183949(+) ACAAAC/TGTTAA 1 -- int10--------
    rs1826615521,2
    C--104183950(+) CAAACA/GTTAAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for CUEDC2 (104183002 - 104192423 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CUEDC2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv895970CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CUEDC2
    DNA2.0 Custom Variant and Variant Library Synthesis for CUEDC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614142    OMIM disorders: --

    UniProtKB/Swiss-Prot: CUED2_HUMAN, Q9H467
  • Note=May predict the clinical outcome of tamoxifen therapy of breast cancer patients. Patients with
    tumors that highly express CUEDC2 do not respond to tamoxifen treatment as effectively as those with tumors with
    low expression

  • 7 diseases for CUEDC2:    About MalaCards
    alzheimer's disease    malaria    multiple myeloma    myeloma
    breast cancer    prostate cancer    prostatitis


    CUEDC2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): CUEDC2
    Human Genome Epidemiology (HuGE) Navigator: CUEDC2 (1 document)

    Export disorders for CUEDC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CUEDC2 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with CUEDC2)
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    1. Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer. (PubMed id 21572428)1, 2 Pan X.... Zhang X.M. (Nat. Med. 2011)
    2. CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasome. (PubMed id 17347654)1, 2 Zhang P.-J....Zhang X.-M. (EMBO J. 2007)
    3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. CUEDC2 sensitizes chronic myeloid leukemic cells to imatinib treatment. (PubMed id 24125838)1 Zhang H....Pang T. (Leuk. Res. 2013)
    8. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (Nat. Genet. 2013)
    9. Phosphorylation-triggered CUEDC2 degradation promotes UV-induced G1 arrest through APC/C(Cdh1) regulation. (PubMed id 23776205)1 Zhang W.N....Li H.Y. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79004 HGNC: 28352 AceView: CUEDC2 Ensembl:ENSG00000107874 euGenes: HUgn79004
    ECgene: CUEDC2 H-InvDB: CUEDC2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CUEDC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CUEDC2 gene:
    Search GeneIP for patents involving CUEDC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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