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Aliases for CUEDC2 Gene

Aliases for CUEDC2 Gene

  • CUE Domain Containing 2 2 3 5
  • C10orf66 3 4
  • Chromosome 10 Open Reading Frame 66 2
  • BA18I14.5 3

External Ids for CUEDC2 Gene

Previous HGNC Symbols for CUEDC2 Gene

  • C10orf66

Previous GeneCards Identifiers for CUEDC2 Gene

  • GC10M103848
  • GC10M104172
  • GC10M097816
  • GC10M104184

Summaries for CUEDC2 Gene

GeneCards Summary for CUEDC2 Gene

CUEDC2 (CUE Domain Containing 2) is a Protein Coding gene. Among its related pathways are DNA Damage.

UniProtKB/Swiss-Prot for CUEDC2 Gene

  • Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUEDC2 Gene

Genomics for CUEDC2 Gene

Regulatory Elements for CUEDC2 Gene

Enhancers for CUEDC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CUEDC2 on UCSC Golden Path with GeneCards custom track

Promoters for CUEDC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CUEDC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CUEDC2 Gene

102,423,245 bp from pter
102,432,666 bp from pter
9,422 bases
Minus strand

Genomic View for CUEDC2 Gene

Genes around CUEDC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CUEDC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CUEDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUEDC2 Gene

Proteins for CUEDC2 Gene

  • Protein details for CUEDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CUE domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • D3DR88
    • Q9BWG8

    Protein attributes for CUEDC2 Gene

    287 amino acids
    Molecular mass:
    32009 Da
    Quaternary structure:
    • Interacts with PGR. Interacts with ESR1 in the presence or absence of 17 beta-estradiol.
    • Sequence=AAH00262.1; Type=Erroneous termination; Positions=227; Note=Translated as Glu.; Evidence={ECO:0000305};

neXtProt entry for CUEDC2 Gene

Proteomics data for CUEDC2 Gene at MOPED

Post-translational modifications for CUEDC2 Gene

  • Ubiquitination at Lys 82, Lys 186, Lys 213, Lys 219, Lys 230, Lys 256, Lys 261, Lys 272, and Lys 279
  • Modification sites at PhosphoSitePlus

Other Protein References for CUEDC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CUEDC2 (CUEDC2)
  • Santa Cruz Biotechnology (SCBT) Antibodies for CUEDC2

No data available for DME Specific Peptides for CUEDC2 Gene

Domains & Families for CUEDC2 Gene

Protein Domains for CUEDC2 Gene


Suggested Antigen Peptide Sequences for CUEDC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The CUE domain mediates interaction with PGR and ESR1.
  • Belongs to the CUEDC2 family.
  • The CUE domain mediates interaction with PGR and ESR1.
  • Contains 1 CUE domain.
  • Belongs to the CUEDC2 family.
genes like me logo Genes that share domains with CUEDC2: view

No data available for Gene Families for CUEDC2 Gene

Function for CUEDC2 Gene

Molecular function for CUEDC2 Gene

UniProtKB/Swiss-Prot Function:
Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.
genes like me logo Genes that share phenotypes with CUEDC2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CUEDC2

miRNA for CUEDC2 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CUEDC2 Gene

Localization for CUEDC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CUEDC2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for CUEDC2 Gene COMPARTMENTS Subcellular localization image for CUEDC2 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CUEDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with CUEDC2: view

Pathways & Interactions for CUEDC2 Gene

SuperPathways for CUEDC2 Gene

Superpath Contained pathways
1 DNA Damage
genes like me logo Genes that share pathways with CUEDC2: view

Pathways by source for CUEDC2 Gene

1 Cell Signaling Technology pathway for CUEDC2 Gene

Gene Ontology (GO) - Biological Process for CUEDC2 Gene


No data available for SIGNOR curated interactions for CUEDC2 Gene

Drugs & Compounds for CUEDC2 Gene

No Compound Related Data Available

Transcripts for CUEDC2 Gene

Unigene Clusters for CUEDC2 Gene

CUE domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CUEDC2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - -
SP2: - -
SP3: - - -
SP4: -
SP5: -
SP6: - - -
SP7: -

Relevant External Links for CUEDC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CUEDC2 Gene

mRNA expression in normal human tissues for CUEDC2 Gene

Protein differential expression in normal tissues from HIPED for CUEDC2 Gene

This gene is overexpressed in Bone (56.0) and Fetal Brain (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CUEDC2 Gene

SOURCE GeneReport for Unigene cluster for CUEDC2 Gene Hs.500874

mRNA Expression by UniProt/SwissProt for CUEDC2 Gene

Tissue specificity: Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared to high-grade tumors.
genes like me logo Genes that share expression patterns with CUEDC2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for CUEDC2 Gene

Orthologs for CUEDC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CUEDC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CUEDC2 35
  • 92.11 (n)
  • 94.35 (a)
  • 81 (a)
(Canis familiaris)
Mammalia CUEDC2 35
  • 93.01 (n)
  • 95.45 (a)
  • 95 (a)
(Mus musculus)
Mammalia Cuedc2 35
  • 88.62 (n)
  • 88.03 (a)
Cuedc2 16
Cuedc2 36
  • 88 (a)
(Pan troglodytes)
Mammalia CUEDC2 35
  • 99.88 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Cuedc2 35
  • 88.64 (n)
  • 87.64 (a)
(Monodelphis domestica)
Mammalia CUEDC2 36
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia CUEDC2 36
  • 58 (a)
(Gallus gallus)
Aves CUEDC2 35
  • 62.86 (n)
  • 58.57 (a)
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cuedc2 35
  • 59.41 (n)
  • 54.98 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398317 35
(Danio rerio)
Actinopterygii cuedc2 35
  • 55.19 (n)
  • 46.01 (a)
wufi42e02 35
cuedc2 36
  • 43 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001586 35
  • 48.97 (n)
  • 34.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9636 35
  • 44.36 (n)
  • 30.8 (a)
CG9636 36
  • 26 (a)
Species with no ortholog for CUEDC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CUEDC2 Gene

Gene Tree for CUEDC2 (if available)
Gene Tree for CUEDC2 (if available)

Paralogs for CUEDC2 Gene

No data available for Paralogs for CUEDC2 Gene

Variants for CUEDC2 Gene

Sequence variations from dbSNP and Humsavar for CUEDC2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1572530 -- 102,434,077(-) CTTGG(C/T)ACTGC upstream-variant-2KB
rs1572531 -- 102,433,976(-) CACGA(A/G)GGAAC upstream-variant-2KB
rs3210927 -- 102,423,806(+) TTCAT(A/C/G/T)CTGCA reference, synonymous-codon
rs3837341 -- 102,432,428(-) CCCCC(-/C)GGGGC intron-variant
rs11595402 -- 102,434,396(+) AAAAA(A/G)AAGAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CUEDC2 Gene

Variant ID Type Subtype PubMed ID
nsv895970 CNV Loss 21882294

Variation tolerance for CUEDC2 Gene

Residual Variation Intolerance Score: 33.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.27% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CUEDC2 Gene

Disorders for CUEDC2 Gene


  • Note=May predict the clinical outcome of tamoxifen therapy of breast cancer patients. Patients with tumors that highly express CUEDC2 do not respond to tamoxifen treatment as effectively as those with tumors with low expression.

Relevant External Links for CUEDC2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CUEDC2 Gene.

No data available for MalaCards and Genatlas for CUEDC2 Gene

Publications for CUEDC2 Gene

  1. CUEDC2 interacts with heat shock protein 70 and negatively regulates its chaperone activity. (PMID: 24685480) Gong L. … Chen L. (Biochem. Biophys. Res. Commun. 2014) 2 3 67
  2. A genome-wide association study of autism using the Simons Simplex Collection: Does reducing phenotypic heterogeneity in autism increase genetic homogeneity? (PMID: 25534755) Chaste P. … Devlin B. (Biol. Psychiatry 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Dysregulation of the miR-324-5p-CUEDC2 axis leads to macrophage dysfunction and is associated with colon cancer. (PMID: 24882011) Chen Y. … Li T. (Cell Rep 2014) 3
  5. Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover. (PMID: 24999758) Elzi D.J. … Shiio Y. (J. Proteome Res. 2014) 3

Products for CUEDC2 Gene

Sources for CUEDC2 Gene