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Aliases for CUEDC2 Gene

Aliases for CUEDC2 Gene

  • CUE Domain Containing 2 2 3
  • C10orf66 3 4
  • Chromosome 10 Open Reading Frame 66 2
  • CUE Domain-Containing Protein 2 3
  • BA18I14.5 3

External Ids for CUEDC2 Gene

Previous HGNC Symbols for CUEDC2 Gene

  • C10orf66

Previous GeneCards Identifiers for CUEDC2 Gene

  • GC10M103848
  • GC10M104172
  • GC10M097816
  • GC10M104184

Summaries for CUEDC2 Gene

GeneCards Summary for CUEDC2 Gene

CUEDC2 (CUE Domain Containing 2) is a Protein Coding gene. Among its related pathways are Cell Cycle / Checkpoint Control.

UniProtKB/Swiss-Prot for CUEDC2 Gene

  • Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUEDC2 Gene

Genomics for CUEDC2 Gene

Regulatory Elements for CUEDC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CUEDC2 Gene

Start:
102,423,245 bp from pter
End:
102,432,669 bp from pter
Size:
9,425 bases
Orientation:
Minus strand

Genomic View for CUEDC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CUEDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUEDC2 Gene

Proteins for CUEDC2 Gene

  • Protein details for CUEDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H467-CUED2_HUMAN
    Recommended name:
    CUE domain-containing protein 2
    Protein Accession:
    Q9H467
    Secondary Accessions:
    • D3DR88
    • Q9BWG8

    Protein attributes for CUEDC2 Gene

    Size:
    287 amino acids
    Molecular mass:
    32009 Da
    Quaternary structure:
    • Interacts with PGR. Interacts with ESR1 in the presence or absence of 17 beta-estradiol.
    SequenceCaution:
    • Sequence=AAH00262.1; Type=Erroneous termination; Positions=227; Note=Translated as Glu.; Evidence={ECO:0000305};

neXtProt entry for CUEDC2 Gene

Proteomics data for CUEDC2 Gene at MOPED

Post-translational modifications for CUEDC2 Gene

  • Ubiquitination at Lys82, Lys186, Lys213, Lys219, Lys230, Lys256, Lys261, Lys272, and Lys279
  • Modification sites at PhosphoSitePlus

Other Protein References for CUEDC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CUEDC2 (CUEDC2)
  • Santa Cruz Biotechnology (SCBT) Antibodies for CUEDC2

No data available for DME Specific Peptides for CUEDC2 Gene

Domains for CUEDC2 Gene

Protein Domains for CUEDC2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CUEDC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H467

UniProtKB/Swiss-Prot:

CUED2_HUMAN :
  • Q9H467
Domain:
  • The CUE domain mediates interaction with PGR and ESR1
  • Contains 1 CUE domain.
Family:
  • Belongs to the CUEDC2 family.
genes like me logo Genes that share domains with CUEDC2: view

No data available for Gene Families for CUEDC2 Gene

Function for CUEDC2 Gene

Molecular function for CUEDC2 Gene

UniProtKB/Swiss-Prot Function: Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.

Gene Ontology (GO) - Molecular Function for CUEDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17347654
genes like me logo Genes that share ontologies with CUEDC2: view

Animal Model Products

CRISPR Products

miRNA for CUEDC2 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CUEDC2 Gene

Localization for CUEDC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CUEDC2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CUEDC2 Gene COMPARTMENTS Subcellular localization image for CUEDC2 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CUEDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with CUEDC2: view

Pathways for CUEDC2 Gene

SuperPathways for CUEDC2 Gene

genes like me logo Genes that share pathways with CUEDC2: view

Pathways by source for CUEDC2 Gene

1 Cell Signaling Technology pathway for CUEDC2 Gene

Gene Ontology (GO) - Biological Process for CUEDC2 Gene

None

Transcripts for CUEDC2 Gene

mRNA/cDNA for CUEDC2 Gene

Unigene Clusters for CUEDC2 Gene

CUE domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CUEDC2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CUEDC2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - -
SP2: - -
SP3: - - -
SP4: -
SP5: -
SP6: - - -
SP7: -
SP8:

Relevant External Links for CUEDC2 Gene

GeneLoc Exon Structure for
CUEDC2
ECgene alternative splicing isoforms for
CUEDC2

Expression for CUEDC2 Gene

mRNA expression in normal human tissues for CUEDC2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CUEDC2 Gene

SOURCE GeneReport for Unigene cluster for CUEDC2 Gene Hs.500874

mRNA Expression by UniProt/SwissProt for CUEDC2 Gene

Q9H467-CUED2_HUMAN
Tissue specificity: Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared to high-grade tumors
genes like me logo Genes that share expressions with CUEDC2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CUEDC2 Gene

Orthologs for CUEDC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CUEDC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CUEDC2 35
  • 99.88 (n)
  • 100 (a)
CUEDC2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CUEDC2 35
  • 92.11 (n)
  • 94.35 (a)
CUEDC2 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CUEDC2 35
  • 93.01 (n)
  • 95.45 (a)
CUEDC2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cuedc2 35
  • 88.62 (n)
  • 88.03 (a)
Cuedc2 16
Cuedc2 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CUEDC2 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CUEDC2 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cuedc2 35
  • 88.64 (n)
  • 87.64 (a)
chicken
(Gallus gallus)
Aves CUEDC2 35
  • 62.86 (n)
  • 58.57 (a)
CUEDC2 36
  • 46 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398317 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cuedc2 35
  • 59.41 (n)
  • 54.98 (a)
zebrafish
(Danio rerio)
Actinopterygii cuedc2 35
  • 55.19 (n)
  • 46.01 (a)
cuedc2 36
  • 43 (a)
OneToOne
wufi42e02 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001586 35
  • 48.97 (n)
  • 34.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9636 35
  • 44.36 (n)
  • 30.8 (a)
CG9636 36
  • 26 (a)
OneToOne
Species with no ortholog for CUEDC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CUEDC2 Gene

ENSEMBL:
Gene Tree for CUEDC2 (if available)
TreeFam:
Gene Tree for CUEDC2 (if available)

Paralogs for CUEDC2 Gene

No data available for Paralogs for CUEDC2 Gene

Variants for CUEDC2 Gene

Sequence variations from dbSNP and Humsavar for CUEDC2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1044476 -- 102,424,324(-) CGGCC(C/T)GAAAT reference, synonymous-codon, nc-transcript-variant
rs1409312 -- 102,432,043(-) GGCTG(A/G)GAGAA intron-variant
rs1409313 -- 102,431,844(-) TCTCT(A/G)TCTAG intron-variant
rs1572530 -- 102,434,077(-) CTTGG(C/T)ACTGC upstream-variant-2KB
rs1572531 -- 102,433,976(-) CACGA(A/G)GGAAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CUEDC2 Gene

Variant ID Type Subtype PubMed ID
nsv895970 CNV Loss 21882294

Relevant External Links for CUEDC2 Gene

HapMap Linkage Disequilibrium report
CUEDC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CUEDC2 Gene

Disorders for CUEDC2 Gene

UniProtKB/Swiss-Prot

CUED2_HUMAN
  • Note=May predict the clinical outcome of tamoxifen therapy of breast cancer patients. Patients with tumors that highly express CUEDC2 do not respond to tamoxifen treatment as effectively as those with tumors with low expression.

Relevant External Links for CUEDC2

Genetic Association Database (GAD)
CUEDC2
Human Genome Epidemiology (HuGE) Navigator
CUEDC2
genes like me logo Genes that share disorders with CUEDC2: view

Publications for CUEDC2 Gene

  1. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  4. CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasome. (PMID: 17347654) Zhang P.-J. … Zhang X.-M. (EMBO J. 2007) 3 4
  5. Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer. (PMID: 21572428) Pan X. … Zhang X.M. (Nat. Med. 2011) 3 4

Products for CUEDC2 Gene

Sources for CUEDC2 Gene

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