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Aliases for CUEDC1 Gene

Aliases for CUEDC1 Gene

  • CUE Domain Containing 1 2 3

External Ids for CUEDC1 Gene

Previous GeneCards Identifiers for CUEDC1 Gene

  • GC17M056415
  • GC17M053295
  • GC17M055940
  • GC17M051300

Summaries for CUEDC1 Gene

GeneCards Summary for CUEDC1 Gene

CUEDC1 (CUE Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUEDC1 Gene

Genomics for CUEDC1 Gene

Regulatory Elements for CUEDC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CUEDC1 Gene

57,861,243 bp from pter
57,955,323 bp from pter
94,081 bases
Minus strand

Genomic View for CUEDC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CUEDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUEDC1 Gene

Proteins for CUEDC1 Gene

  • Protein details for CUEDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CUE domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • D3DTZ2
    • Q9NWD0

    Protein attributes for CUEDC1 Gene

    386 amino acids
    Molecular mass:
    42258 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CUEDC1 Gene

    Alternative splice isoforms for CUEDC1 Gene


neXtProt entry for CUEDC1 Gene

Proteomics data for CUEDC1 Gene at MOPED

Post-translational modifications for CUEDC1 Gene

  • Ubiquitination at Lys 228, Lys 318, and Lys 342
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CUEDC1 Gene

Domains & Families for CUEDC1 Gene

Protein Domains for CUEDC1 Gene


Suggested Antigen Peptide Sequences for CUEDC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CUE domain.
  • Contains 1 CUE domain.
genes like me logo Genes that share domains with CUEDC1: view

No data available for Gene Families for CUEDC1 Gene

Function for CUEDC1 Gene

Gene Ontology (GO) - Molecular Function for CUEDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CUEDC1: view

Phenotypes for CUEDC1 Gene

genes like me logo Genes that share phenotypes with CUEDC1: view

miRNA for CUEDC1 Gene

miRTarBase miRNAs that target CUEDC1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CUEDC1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CUEDC1 Gene

Localization for CUEDC1 Gene

Subcellular locations from

Jensen Localization Image for CUEDC1 Gene COMPARTMENTS Subcellular localization image for CUEDC1 gene
Compartment Confidence
cytoskeleton 2
cytosol 2
mitochondrion 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CUEDC1 Gene

Pathways & Interactions for CUEDC1 Gene

SuperPathways for CUEDC1 Gene

No Data Available

Interacting Proteins for CUEDC1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)
Selected Interacting proteins: Q9NWM3-CUED1_HUMAN ENSP00000353373 for CUEDC1 Gene via I2D MINT STRING

Gene Ontology (GO) - Biological Process for CUEDC1 Gene


No data available for Pathways by source and SIGNOR curated interactions for CUEDC1 Gene

Drugs & Compounds for CUEDC1 Gene

No Compound Related Data Available

Transcripts for CUEDC1 Gene

Unigene Clusters for CUEDC1 Gene

CUE domain containing 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CUEDC1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CUEDC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c
SP1: - - - -
SP2: - - - - -
SP3: - - - - - - - - -
SP4: - -
SP5: - - -
SP6: - -
SP7: -
SP9: -

Relevant External Links for CUEDC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CUEDC1 Gene

mRNA expression in normal human tissues for CUEDC1 Gene

Protein differential expression in normal tissues from HIPED for CUEDC1 Gene

This gene is overexpressed in Lung (32.7), Frontal cortex (14.0), Urinary Bladder (10.8), and Prostate (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CUEDC1 Gene

SOURCE GeneReport for Unigene cluster for CUEDC1 Gene Hs.46679

genes like me logo Genes that share expression patterns with CUEDC1: view

Protein tissue co-expression partners for CUEDC1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CUEDC1 Gene

Orthologs for CUEDC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CUEDC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CUEDC1 35
  • 88.23 (n)
  • 90.11 (a)
  • 89 (a)
(Canis familiaris)
Mammalia CUEDC1 35
  • 87.66 (n)
  • 89.55 (a)
  • 84 (a)
(Mus musculus)
Mammalia Cuedc1 35
  • 85.35 (n)
  • 88.45 (a)
Cuedc1 16
Cuedc1 36
  • 87 (a)
(Pan troglodytes)
Mammalia CUEDC1 35
  • 98.97 (n)
  • 98.04 (a)
  • 97 (a)
(Rattus norvegicus)
Mammalia Cuedc1 35
  • 85.82 (n)
  • 89.01 (a)
(Monodelphis domestica)
Mammalia CUEDC1 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia CUEDC1 36
  • 77 (a)
(Gallus gallus)
Aves CUEDC1 35
  • 77.01 (n)
  • 81.79 (a)
  • 75 (a)
(Anolis carolinensis)
Reptilia CUEDC1 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cuedc1 35
  • 67.25 (n)
  • 72.59 (a)
(Danio rerio)
Actinopterygii cuedc1b 35
  • 68.13 (n)
  • 71.93 (a)
cuedc1a 36
  • 57 (a)
cuedc1b 36
  • 66 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006084 35
  • 53.8 (n)
  • 44.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12024 35
  • 54.7 (n)
  • 42.31 (a)
CG12024 36
  • 36 (a)
Species with no ortholog for CUEDC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CUEDC1 Gene

Gene Tree for CUEDC1 (if available)
Gene Tree for CUEDC1 (if available)

Paralogs for CUEDC1 Gene

(1) SIMAP similar genes for CUEDC1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CUEDC1: view

No data available for Paralogs for CUEDC1 Gene

Variants for CUEDC1 Gene

Sequence variations from dbSNP and Humsavar for CUEDC1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs744930 -- 57,869,408(+) TCAGC(C/G/T)GTCTA intron-variant
rs747793 -- 57,926,671(-) TTAGA(A/G)TTTGA intron-variant
rs753048 -- 57,925,864(+) GCCAG(C/T)AAAGA intron-variant
rs894595 -- 57,917,066(-) TTGGA(C/T)GGGCC intron-variant
rs1017528 -- 57,935,190(-) AAACC(A/G)TTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CUEDC1 Gene

Variant ID Type Subtype PubMed ID
nsv828066 CNV Loss 20364138

Variation tolerance for CUEDC1 Gene

Residual Variation Intolerance Score: 22.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.87; 74.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CUEDC1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CUEDC1 Gene

Disorders for CUEDC1 Gene

Relevant External Links for CUEDC1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CUEDC1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CUEDC1 Gene

Publications for CUEDC1 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. (PMID: 25260751) Charlaftis N. … Gallagher E. (EMBO J. 2014) 67
  3. Expanding the substantial interactome of NEMO using protein microarrays. (PMID: 20098747) Fenner B.J. … Prehn J.H. (PLoS ONE 2010) 67
  4. Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis. (PMID: 20802204) Baranzini S.E. … Pelletier D. (Brain 2010) 67
  5. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PMID: 19953087) Persaud A. … Rotin D. (Mol. Syst. Biol. 2009) 67

Products for CUEDC1 Gene

Sources for CUEDC1 Gene

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