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Aliases for CUEDC1 Gene

Aliases for CUEDC1 Gene

  • CUE Domain Containing 1 2 3

External Ids for CUEDC1 Gene

Previous GeneCards Identifiers for CUEDC1 Gene

  • GC17M056415
  • GC17M053295
  • GC17M055940
  • GC17M051300

Summaries for CUEDC1 Gene

GeneCards Summary for CUEDC1 Gene

CUEDC1 (CUE Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUEDC1 Gene

Genomics for CUEDC1 Gene

Regulatory Elements for CUEDC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CUEDC1 Gene

Start:
57,861,243 bp from pter
End:
57,955,323 bp from pter
Size:
94,081 bases
Orientation:
Minus strand

Genomic View for CUEDC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CUEDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUEDC1 Gene

Proteins for CUEDC1 Gene

  • Protein details for CUEDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWM3-CUED1_HUMAN
    Recommended name:
    CUE domain-containing protein 1
    Protein Accession:
    Q9NWM3
    Secondary Accessions:
    • D3DTZ2
    • Q9NWD0

    Protein attributes for CUEDC1 Gene

    Size:
    386 amino acids
    Molecular mass:
    42258 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CUEDC1 Gene

    Alternative splice isoforms for CUEDC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CUEDC1 Gene

Proteomics data for CUEDC1 Gene at MOPED

Post-translational modifications for CUEDC1 Gene

  • Ubiquitination at Lys228, Lys318, and Lys342
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CUEDC1 Gene

Domains for CUEDC1 Gene

Protein Domains for CUEDC1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CUEDC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NWM3

UniProtKB/Swiss-Prot:

CUED1_HUMAN :
  • Q9NWM3
Domain:
  • Contains 1 CUE domain.
genes like me logo Genes that share domains with CUEDC1: view

No data available for Gene Families for CUEDC1 Gene

Function for CUEDC1 Gene

Gene Ontology (GO) - Molecular Function for CUEDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CUEDC1: view

Phenotypes for CUEDC1 Gene

GenomeRNAi human phenotypes for CUEDC1:
genes like me logo Genes that share phenotypes with CUEDC1: view

Animal Model Products

CRISPR Products

miRNA for CUEDC1 Gene

miRTarBase miRNAs that target CUEDC1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CUEDC1 Gene

Localization for CUEDC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CUEDC1 Gene COMPARTMENTS Subcellular localization image for CUEDC1 gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CUEDC1 Gene

Pathways for CUEDC1 Gene

SuperPathways for CUEDC1 Gene

No Data Available

Interacting Proteins for CUEDC1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000353373%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000368818%0d%0a9606.ENSP00000413697%0d%0a9606.ENSP00000358622%0d%0a9606.ENSP00000460823%0d%0a
Selected Interacting proteins: Q9NWM3-CUED1_HUMAN ENSP00000353373 for CUEDC1 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for CUEDC1 Gene

None

No data available for Pathways by source for CUEDC1 Gene

Transcripts for CUEDC1 Gene

Unigene Clusters for CUEDC1 Gene

CUE domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CUEDC1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CUEDC1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CUEDC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c
SP1: - - - -
SP2: - - - - -
SP3: - - - - - - - - -
SP4: - -
SP5: - - -
SP6: - -
SP7: -
SP8:
SP9: -
SP10:

Relevant External Links for CUEDC1 Gene

GeneLoc Exon Structure for
CUEDC1
ECgene alternative splicing isoforms for
CUEDC1

Expression for CUEDC1 Gene

mRNA expression in normal human tissues for CUEDC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CUEDC1 Gene

SOURCE GeneReport for Unigene cluster for CUEDC1 Gene Hs.46679

genes like me logo Genes that share expressions with CUEDC1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CUEDC1 Gene

Orthologs for CUEDC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CUEDC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CUEDC1 35
  • 98.97 (n)
  • 98.04 (a)
CUEDC1 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CUEDC1 35
  • 88.23 (n)
  • 90.11 (a)
CUEDC1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CUEDC1 35
  • 87.66 (n)
  • 89.55 (a)
CUEDC1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cuedc1 35
  • 85.35 (n)
  • 88.45 (a)
Cuedc1 16
Cuedc1 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CUEDC1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CUEDC1 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cuedc1 35
  • 85.82 (n)
  • 89.01 (a)
chicken
(Gallus gallus)
Aves CUEDC1 35
  • 77.01 (n)
  • 81.79 (a)
CUEDC1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CUEDC1 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cuedc1 35
  • 67.25 (n)
  • 72.59 (a)
zebrafish
(Danio rerio)
Actinopterygii cuedc1a 36
  • 57 (a)
OneToMany
cuedc1b 35
  • 68.13 (n)
  • 71.93 (a)
cuedc1b 36
  • 66 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006084 35
  • 53.8 (n)
  • 44.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12024 35
  • 54.7 (n)
  • 42.31 (a)
CG12024 36
  • 36 (a)
OneToOne
Species with no ortholog for CUEDC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CUEDC1 Gene

ENSEMBL:
Gene Tree for CUEDC1 (if available)
TreeFam:
Gene Tree for CUEDC1 (if available)

Paralogs for CUEDC1 Gene

Selected SIMAP similar genes for CUEDC1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CUEDC1: view

No data available for Paralogs for CUEDC1 Gene

Variants for CUEDC1 Gene

Sequence variations from dbSNP and Humsavar for CUEDC1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs744930 -- 57,869,408(+) TCAGC(C/G)GTCTA intron-variant
rs747793 -- 57,926,671(-) TTAGA(A/G)TTTGA intron-variant
rs753048 -- 57,925,864(+) GCCAG(C/T)AAAGA intron-variant
rs894595 -- 57,917,066(-) TTGGA(C/T)GGGCC intron-variant
rs1017528 -- 57,935,190(-) AAACC(A/G)TTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CUEDC1 Gene

Variant ID Type Subtype PubMed ID
nsv828066 CNV Loss 20364138

Relevant External Links for CUEDC1 Gene

HapMap Linkage Disequilibrium report
CUEDC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CUEDC1 Gene

Disorders for CUEDC1 Gene

Relevant External Links for CUEDC1

Genetic Association Database (GAD)
CUEDC1
genes like me logo Genes that share disorders with CUEDC1: view

No data available for UniProtKB/Swiss-Prot for CUEDC1 Gene

Publications for CUEDC1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis. (PMID: 20802204) Baranzini S.E. … Pelletier D. (Brain 2010) 3 48
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PMID: 19953087) Persaud A. … Rotin D. (Mol. Syst. Biol. 2009) 3
  5. Expanding the substantial interactome of NEMO using protein microarrays. (PMID: 20098747) Fenner B.J. … Prehn J.H. (PLoS ONE 2010) 3

Products for CUEDC1 Gene

Sources for CUEDC1 Gene

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