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Aliases for CUEDC1 Gene

Aliases for CUEDC1 Gene

  • CUE Domain Containing 1 2 3 5

External Ids for CUEDC1 Gene

Previous GeneCards Identifiers for CUEDC1 Gene

  • GC17M056415
  • GC17M053295
  • GC17M055940
  • GC17M051300

Summaries for CUEDC1 Gene

GeneCards Summary for CUEDC1 Gene

CUEDC1 (CUE Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUEDC1 Gene

Genomics for CUEDC1 Gene

Regulatory Elements for CUEDC1 Gene

Enhancers for CUEDC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F057888 0.6 FANTOM5 ENCODE 18.9 +63.0 62972 7.9 PKNOX1 ZFP64 SIN3A YBX1 FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF207 SRSF1 COIL ENSG00000262298 CUEDC1 ENSG00000264112 EPX SUPT4H1 VEZF1 ENSG00000264914 GC17P057856
GH17F057897 1.4 FANTOM5 Ensembl ENCODE 18.6 +53.4 53423 8.6 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 SRSF1 CUEDC1 ENSG00000262298 COIL EPX VEZF1 ENSG00000263004 OR4D2 ENSG00000264914 GC17P057856
GH17F057872 1.2 FANTOM5 Ensembl ENCODE 18.1 +80.3 80257 4.9 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 GLIS2 ZNF143 CUEDC1 MRPS23 MKS1 SRSF1 TSPOAP1 GC17P057856 ENSG00000264914
GH17F057877 0.9 Ensembl ENCODE 18.1 +74.7 74745 5.6 ZFP64 ARID4B SIN3A DMAP1 GLIS2 FOS SP5 MXD4 PPARG ZNF518A SRSF1 COIL CUEDC1 VEZF1 MRPS23 ENSG00000262298 GC17P057856 ENSG00000264914
GH17F057866 1.3 FANTOM5 Ensembl ENCODE 15.8 +86.3 86259 5.0 HDGF ELF3 KLF17 ARID4B SIN3A ZNF48 ZNF2 RAD21 GLIS2 SCRT2 CUEDC1 GC17P057856 ENSG00000264914
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CUEDC1 on UCSC Golden Path with GeneCards custom track

Promoters for CUEDC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001349811 323 1601 ARID4B SIN3A FEZF1 ZNF48 GLIS2 KLF7 ZNF263 SP3 SP5 KAT8

Genomic Location for CUEDC1 Gene

57,861,243 bp from pter
57,955,323 bp from pter
94,081 bases
Minus strand

Genomic View for CUEDC1 Gene

Genes around CUEDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CUEDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CUEDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUEDC1 Gene

Proteins for CUEDC1 Gene

  • Protein details for CUEDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CUE domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • D3DTZ2
    • Q9NWD0

    Protein attributes for CUEDC1 Gene

    386 amino acids
    Molecular mass:
    42258 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CUEDC1 Gene

    Alternative splice isoforms for CUEDC1 Gene


neXtProt entry for CUEDC1 Gene

Post-translational modifications for CUEDC1 Gene

  • Ubiquitination at Lys 228, Lys 318, and Lys 342
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for CUEDC1
  • Santa Cruz Biotechnology (SCBT) Antibodies for CUEDC1

No data available for DME Specific Peptides for CUEDC1 Gene

Domains & Families for CUEDC1 Gene

Protein Domains for CUEDC1 Gene

Suggested Antigen Peptide Sequences for CUEDC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CUE domain.
  • Contains 1 CUE domain.
genes like me logo Genes that share domains with CUEDC1: view

No data available for Gene Families for CUEDC1 Gene

Function for CUEDC1 Gene

genes like me logo Genes that share phenotypes with CUEDC1: view

Animal Model Products

miRNA for CUEDC1 Gene

miRTarBase miRNAs that target CUEDC1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CUEDC1 Gene

Localization for CUEDC1 Gene

Subcellular locations from

Jensen Localization Image for CUEDC1 Gene COMPARTMENTS Subcellular localization image for CUEDC1 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 2
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CUEDC1 Gene

Pathways & Interactions for CUEDC1 Gene

SuperPathways for CUEDC1 Gene

No Data Available

Interacting Proteins for CUEDC1 Gene

Gene Ontology (GO) - Biological Process for CUEDC1 Gene


No data available for Pathways by source and SIGNOR curated interactions for CUEDC1 Gene

Transcripts for CUEDC1 Gene

Unigene Clusters for CUEDC1 Gene

CUE domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CUEDC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c
SP1: - - - -
SP2: - - - - -
SP3: - - - - - - - - -
SP4: - -
SP5: - - -
SP6: - -
SP7: -
SP9: -

Relevant External Links for CUEDC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CUEDC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CUEDC1 Gene

Protein differential expression in normal tissues from HIPED for CUEDC1 Gene

This gene is overexpressed in Lung (32.7), Frontal cortex (14.0), Urinary Bladder (10.8), and Prostate (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CUEDC1 Gene

Protein tissue co-expression partners for CUEDC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CUEDC1 Gene:


SOURCE GeneReport for Unigene cluster for CUEDC1 Gene:

genes like me logo Genes that share expression patterns with CUEDC1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CUEDC1 Gene

Orthologs for CUEDC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CUEDC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CUEDC1 34 35
  • 98.97 (n)
(Bos Taurus)
Mammalia CUEDC1 34 35
  • 88.23 (n)
(Canis familiaris)
Mammalia CUEDC1 34 35
  • 87.66 (n)
(Rattus norvegicus)
Mammalia Cuedc1 34
  • 85.82 (n)
(Mus musculus)
Mammalia Cuedc1 34 16 35
  • 85.35 (n)
(Monodelphis domestica)
Mammalia CUEDC1 35
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia CUEDC1 35
  • 77 (a)
(Gallus gallus)
Aves CUEDC1 34 35
  • 77.01 (n)
(Anolis carolinensis)
Reptilia CUEDC1 35
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cuedc1 34
  • 67.25 (n)
(Danio rerio)
Actinopterygii cuedc1b 34 35
  • 68.13 (n)
cuedc1a 35
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12024 34 35
  • 54.7 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006084 34
  • 53.8 (n)
Species where no ortholog for CUEDC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CUEDC1 Gene

Gene Tree for CUEDC1 (if available)
Gene Tree for CUEDC1 (if available)

Paralogs for CUEDC1 Gene

(1) SIMAP similar genes for CUEDC1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CUEDC1: view

No data available for Paralogs for CUEDC1 Gene

Variants for CUEDC1 Gene

Sequence variations from dbSNP and Humsavar for CUEDC1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1017528 -- 57,935,190(-) AAACC(A/G)TTCAT intron-variant
rs1047834 -- 57,861,756(-) GGTCT(C/T)TGAGC nc-transcript-variant, utr-variant-3-prime
rs10515151 -- 57,928,595(+) CCCTC(C/T)GATGC intron-variant
rs10515152 -- 57,928,631(+) GATCT(A/T)CCGAT intron-variant
rs10528320 -- 57,878,686(+) ATTTA(-/TTTA)CTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CUEDC1 Gene

Variant ID Type Subtype PubMed ID
esv3305376 CNV mobile element insertion 20981092
esv3308644 CNV mobile element insertion 20981092
esv3327169 CNV insertion 20981092
esv3341518 CNV insertion 20981092
esv3450717 CNV insertion 20981092
esv3554598 CNV deletion 23714750
nsv1070836 CNV deletion 25765185
nsv1116227 CNV deletion 24896259
nsv1143859 CNV deletion 24896259
nsv828066 CNV loss 20364138
nsv833497 CNV loss 17160897
nsv952346 CNV deletion 24416366

Variation tolerance for CUEDC1 Gene

Residual Variation Intolerance Score: 22.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.87; 74.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CUEDC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CUEDC1 Gene

Disorders for CUEDC1 Gene

Relevant External Links for CUEDC1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CUEDC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CUEDC1 Gene

Publications for CUEDC1 Gene

  1. Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis. (PMID: 20802204) Baranzini S.E. … Pelletier D. (Brain 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. (PMID: 25260751) Charlaftis N. … Gallagher E. (EMBO J. 2014) 3 64

Products for CUEDC1 Gene

Sources for CUEDC1 Gene

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