CUEDC1 Gene
protein-coding GIFtS: 46
GCID: GC17M055940
|
|
CUE domain containing 1
| |
Aliases
for CUEDC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CUE Domain Containing 11 2 | | CUE Domain-Containing Protein 12 |
Export aliases for CUEDC1 gene to outside databasesPrevious GC identifers: GC17M056415 GC17M053295 GC17M051300 |
Summaries
for CUEDC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CUEDC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CUEDC1 gene promoter:
AML1a GATA-3 Tal-1 Lmo2 E47 HEN1 c-Rel Sox9 FOXO1a FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CUEDC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CUEDC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q23.2 Ensembl cytogenetic band: 17q22 HGNC cytogenetic band: 17q23.2CUEDC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M055940: view genomic region
(about GC identifiers)
Start:
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55,938,604 bp from pter |
End:
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56,032,684 bp from pter |
Size:
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94,081 bases |
Orientation:
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minus strand |
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Proteins
for CUEDC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CUED1_HUMAN, Q9NWM3 (See
protein sequence)Recommended Name: CUE domain-containing protein 1 Size: 386 amino acids; 42258 Da
1 PDB 3D structure from  and Proteopedia  for CUEDC1:2DHY (3D)
Secondary accessions: D3DTZ2 Q9NWD0Alternative splicing: 2 isoforms: Q9NWM3-1 Q9NWM3-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CUEDC1: NX_Q9NWM3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NWM3
CUEDC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001258804.1 NP_060419.1
ENSEMBL proteins: ENSP00000462717 ENSP00000384712 ENSP00000462045 ENSP00000462177 ENSP00000353373 ENSP00000463666 ENSP00000462789
Human Recombinant Protein Products:
CUEDC1 Antibody Products:
Assay Products for CUEDC1: |
Protein
Domains /
Families
for CUEDC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CUEDC1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NWM3ProtoNet protein and cluster: Q9NWM3 1 Blocks protein family: IPB003892 Ubiquitin system component Cue
UniProtKB/Swiss-Prot: CUED1_HUMAN, Q9NWM3Similarity: Contains 1 CUE domain |
Function
for CUEDC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CUEDC1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CUEDC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CUEDC1 (NM_017949) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CUEDC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUEDC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUEDC1 |
1 GenomeRNAi human phenotype for CUEDC1:
|
Pathways & Interactions
for CUEDC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CUEDC1
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for CUEDC1 (Q9NWM32, 3 ENSP000003533734) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for CUEDC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CUEDC1
Search CenterWatch for drugs/clinical trials and news about CUEDC1 / CUED1
|
Transcripts
for CUEDC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CUEDC1 gene (2 alternative transcripts): NM_001271875.1 NM_017949.1 Unigene Cluster for CUEDC1: CUE domain containing 1 Hs.46679 [show with all ESTs]Unigene Representative Sequence: NR_07349513 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000577830(uc002ive.1) ENST00000584746 ENST00000407144 ENST00000577422
ENST00000582951 ENST00000581391 ENST00000577497 ENST00000578357 ENST00000581898
ENST00000585294 ENST00000360238(uc002ivd.1) ENST00000577840 ENST00000577589
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CUEDC1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CUEDC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CUEDC1 (NM_017949) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CUEDC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUEDC1 |
Additional cDNA sequence: AK000746.1 AK000977.1 BC056882.1 NR_073495.1 17 DOTS entries: DT.100091 DT.91939610 DT.100817511 DT.411821 DT.100817512 DT.95272725 DT.91717862 DT.100817513 DT.95272723 DT.97820894 DT.120901230 DT.97776374 DT.100029697 DT.100711604 DT.100817515 DT.91717858 DT.40228699 24/180 AceView cDNA sequences (see all 180): CB241425 BM994938 BM726395 AA707921 BM671784 AI871822 BQ960630 BC056882 BU686119 BX092396 BM709335 AI524442 AI281783 CA428549 BQ934581 BU685215 BU631252 AA293162 BU509455 BE870865 BQ019864 CR627470 BU732837 CF454298
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CUEDC1 (see all 10) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | - | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | - | | | | - | | | | - | | | | | | |
| SP3: | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | - | | | | | |
ECgene alternative splicing isoforms for CUEDC1
|
Expression
for CUEDC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CUEDC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGACTTAGAA
About this image
See CUEDC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CUEDC1
SOURCE GeneReport for Unigene cluster: Hs.46679
SABiosciences Custom PCR Arrays for CUEDC1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CUEDC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CUEDC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CUEDC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CUEDC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUEDC1 |
Orthologs
for CUEDC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CUEDC1 gene from 5/15 species (see all 15) About this table
ENSEMBL Gene Tree for CUEDC1 (if available)
TreeFam Gene Tree for CUEDC1 (if available) |
Paralogs
for CUEDC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CUEDC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CUEDC1 (55938604 - 56032684 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CUEDC1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CUEDC1 |
|
Disorders
/ Diseases
for CUEDC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CUEDC1 for disorders About GeneDecksing
1  disease for CUEDC1: About MalaCardsmultiple sclerosis
Export disorders for CUEDC1 gene to outside databases
|
Publications
for CUEDC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CUEDC1 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with CUEDC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis. (PubMed id 20802204)1 Baranzini S.E....Pelletier D. (2010)
- Expanding the substantial interactome of NEMO using p rotein microarrays. (PubMed id 20098747)1 Fenner B.J....Prehn J.H. (2010)
- Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (2009)
- Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for CUEDC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CUEDC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CUEDC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CUEDC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CUEDC1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CUEDC1 gene:
Search GeneIP for patents involving CUEDC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CUEDC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for CUEDC1 | | OriGene shRNA RFP for CUEDC1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CUEDC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CUEDC1 | | | OriGene Protein Over-expression Lysate for CUEDC1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CUEDC1 | | OriGene 3'-UTR Clone for CUEDC1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CUEDC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CUEDC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CUEDC1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CUEDC1 | | OriGene Custom Protein Services for CUEDC1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CUEDC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CUEDC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CUEDC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CUEDC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CUEDC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CUEDC1 |
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| | | | Search Tocris compounds for CUEDC1 |
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 | | | CUEDC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CUEDC1 |
|  |  |  | | | | ThermoFisher Antibodies for CUEDC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CUEDC1 |
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