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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CTXN3 Gene

protein-coding GIFtS: 37
GCID: GC05P127013

cortexin 3

Explore 1 disease affiliated with
CTXN3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cortexin 3¹ ²
Kidney And Brain-Expressed Protein² ³
KABE² ³
Cortexin-3¹

External Ids:	HGNC: 31110¹	Entrez Gene: 613212²	Ensembl: ENSG00000205279⁷	UniProtKB: Q4LDR2³

Export aliases for CTXN3 gene to outside databases

Previous GC identifers: GC05U900493 GC05P122176

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_034772.6

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CTXN3 gene promoter:
Nkx3-1 Nkx3-1 v4 CUTL1 Nkx3-1 v1 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 RORalpha1 Nkx3-1 v2 Nkx3-1 v3
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for CTXN3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTXN3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.2 Ensembl cytogenetic band: 5q23.2 HGNC cytogenetic band: 5q23.2

CTXN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTXN3 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P127013: view genomic region (about GC identifiers)

Start:	126,984,713 bp from pter	End:	126,994,322 bp from pter
Size:	9,610 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CTXN3_HUMAN, Q4LDR2 (See protein sequence)

Recommended Name: Cortexin-3

Size: 81 amino acids; 8933 Da

Subcellular location: Membrane; Single-pass membrane protein (Potential)

Secondary accessions: B2RV32 D3DQ82

Explore the universe of human proteins at neXtProt for CTXN3: NX_Q4LDR2

CTXN3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001041717.1 NP_001120857.1

ENSEMBL proteins:

ENSP00000368758 ENSP00000378732

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

CTXN3 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CTXN3 for domains About GeneDecksing

1 InterPro domain/family:

IPR020066 Cortexin

Graphical View of Domain Structure for InterPro Entry Q4LDR2

ProtoNet protein and cluster: Q4LDR2

UniProtKB/Swiss-Prot: CTXN3_HUMAN, Q4LDR2

Similarity: Belongs to the cortexin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CTXN3

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for CTXN3 gene (2 alternative transcripts):

NM_001048252.2 NM_001127385.1

Unigene Cluster for CTXN3:

Cortexin 3

Hs.66194 [show with all ESTs]

Unigene Representative Sequence: NM_001048252

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000379445(uc003kul.4) ENST00000514851 ENST00000395322(uc003kum.4)

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Additional cDNA sequence:

AB219764.1 AB219832.1 BC071790.1 BC147012.1

2 DOTS entries:

DT.453800 DT.101967156

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CTXN3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTAGAGGTA

About this image

CTXN3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Head Mesenchyme

Kidney

Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CTXN3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CTXN3

SOURCE GeneReport for Unigene cluster: Hs.66194

SABiosciences Custom PCR Arrays for CTXN3

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CTXN3 gene from 4/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ctxn3^{1 , 5}	cortexin 3^{1, 5}	87.5(n)¹ 93.75(a)¹		18 (32.15 cM)⁵ 629147¹ NM_001134697.1¹ NP_001128169.1¹ 57468486⁵
chicken (Gallus gallus)	Aves	LOC100859328¹	cortexin-3-like	76.13(n) 79.01(a)		100859328 XM_003643064.1 XP_003643112.1
lizard (Anolis carolinensis)	Reptilia	CTXN3⁶	--	65(a)	1 ↔ 1	2(29781499-29781741)
zebrafish (Danio rerio)	Actinopterygii	LOC100331302¹	cortexin-3-like	67.11(n) 72.37(a)		100331302 XM_002663503.1 XP_002663549.1

ENSEMBL Gene Tree for CTXN3 (if available)
TreeFam Gene Tree for CTXN3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CTXN3 gene

CTXN2² CTXN1²

2 SIMAP similar genes for CTXN3 using alignment to 1 protein entry: CTXN3_HUMAN:

CTXN2 CTXN1

CTXN3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6595787^1,2	C,F,A,H,	--	126982737(+)	`TGTATC/TTGAGC`	1	--	us2k¹		19		NS EA NA WA CSA	2340
rs115332102^1,2		--	126982832(+)	`ATAAAG/AATTAT`	1	--	us2k¹		1		WA	118
rs1382330^1,2	C,F,H,	--	126982856(-)	`TAGATC/ACTATT`	1	--	us2k¹ tfbs³		6		NS EA WA	528
rs144028481^1,2		--	126982857(+)	`ATAGGA/TTCTAA`	1	--	us2k¹		0	--	--	--	--
rs189549695^1,2		--	126982872(+)	`AAATGA/TTCAAA`	1	--	us2k¹		0	--	--	--	--
rs181940436^1,2		--	126982882(+)	`ATGGAA/CCTTTG`	1	--	us2k¹		0	--	--	--	--
rs184917315^1,2		--	126983061(+)	`TAGTTC/TGGCTT`	1	--	us2k¹		0	--	--	--	--
rs189049283^1,2		--	126983104(+)	`TGGAGG/TGGTTA`	1	--	us2k¹		0	--	--	--	--
rs114855197^1,2	F,	--	126983131(+)	`AGCAAG/AGACAG`	1	--	us2k¹		1		WA	118
rs139807221^1,2		--	126983151(+)	`AAATGC/TGCCAA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CTXN3 (126984713 - 126994322 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CTXN3: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CTXN3 for disorders About GeneDecksing

1 disease for CTXN3: About MalaCards

schizophrenia

Human Genome Epidemiology (HuGE) Navigator: CTXN3 (1 document)

Export disorders for CTXN3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CTXN3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CTXN3)

Utopia: connect your pdf to the dynamic
world of online information

A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype. (PubMed id 19023125)¹ Potkin S.G....Macciardi F. (2009)
In silico-initiated cloning and molecular characterization of cortexin 3, a novel human gene specifically expressed in the kidney and brain, and well conserved in vertebrates. (PubMed id 17786280)¹ Wang H.T....Li B.G. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 613212	HGNC: 31110	Ensembl:ENSG00000205279	euGenes: HUgn613212	ECgene: CTXN3
H-InvDB: CTXN3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CTXN3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CTXN3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CTXN3 gene:
Search GeneIP for patents involving CTXN3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTXN3

	Browse SwitchGear 3'UTR luciferase reporter plasmids for CTXN3
	Browse SwitchGear Promoter luciferase reporter plasmids for CTXN3

Search ThermoFisher Antibodies for CTXN3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTXN3

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CTXN3 gene at Home site.

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CTXN3 Gene

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CTXN3 Gene

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Aliasesfor CTXN3 gene

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Proteinsfor CTXN3 gene

Protein Domains /Familiesfor CTXN3 gene

Functionfor CTXN3 gene

Pathways & Interactionsfor CTXN3 gene

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Transcriptsfor CTXN3 gene

Expression for CTXN3 gene

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Genomic Variantsfor CTXN3 gene

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Genome Databases showing CTXN3 gene

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Specialized Databases showing CTXN3 gene

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for CTXN3 gene

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for CTXN3 gene

Genomic Views
for CTXN3 gene

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for CTXN3 gene

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for CTXN3 gene

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for CTXN3 gene

Pathways & Interactions
for CTXN3 gene

Drugs & Compounds
for CTXN3 gene

Transcripts
for CTXN3 gene

Expression
for CTXN3 gene

Orthologs
for CTXN3 gene

Paralogs
for CTXN3 gene

Genomic Variants
for CTXN3 gene

Disorders / Diseases
for CTXN3 gene

Publications
for CTXN3 gene

Intellectual Property
for CTXN3 gene

Products
for CTXN3 gene