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Aliases for CTXN3 Gene

Aliases for CTXN3 Gene

  • Cortexin 3 2 3
  • Kidney And Brain-Expressed Protein 3 4
  • KABE 3 4
  • Cortexin-3 3

External Ids for CTXN3 Gene

Previous GeneCards Identifiers for CTXN3 Gene

  • GC05U900493
  • GC05P127013
  • GC05P122176

Summaries for CTXN3 Gene

GeneCards Summary for CTXN3 Gene

CTXN3 (Cortexin 3) is a Protein Coding gene. An important paralog of this gene is CTXN1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTXN3 Gene

Genomics for CTXN3 Gene

Genomic Location for CTXN3 Gene

Start:
127,649,021 bp from pter
End:
127,658,630 bp from pter
Size:
9,610 bases
Orientation:
Plus strand

Genomic View for CTXN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTXN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTXN3 Gene

Proteins for CTXN3 Gene

  • Protein details for CTXN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4LDR2-CTXN3_HUMAN
    Recommended name:
    Cortexin-3
    Protein Accession:
    Q4LDR2
    Secondary Accessions:
    • B2RV32
    • D3DQ82

    Protein attributes for CTXN3 Gene

    Size:
    81 amino acids
    Molecular mass:
    8933 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CTXN3 Gene

Proteomics data for CTXN3 Gene at MOPED

Post-translational modifications for CTXN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTXN3 Gene

No data available for DME Specific Peptides for CTXN3 Gene

Domains for CTXN3 Gene

Protein Domains for CTXN3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CTXN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4LDR2

UniProtKB/Swiss-Prot:

CTXN3_HUMAN :
  • Q4LDR2
Family:
  • Belongs to the cortexin family.
genes like me logo Genes that share domains with CTXN3: view

No data available for Gene Families for CTXN3 Gene

Function for CTXN3 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTXN3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CTXN3 Gene

Localization for CTXN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTXN3 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTXN3 Gene COMPARTMENTS Subcellular localization image for CTXN3 gene
Compartment Confidence
plasma membrane 3
cytosol 1
extracellular 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CTXN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0031224 intrinsic component of membrane --
genes like me logo Genes that share ontologies with CTXN3: view

Pathways for CTXN3 Gene

SuperPathways for CTXN3 Gene

No Data Available

Interacting Proteins for CTXN3 Gene

Gene Ontology (GO) - Biological Process for CTXN3 Gene

None

No data available for Pathways by source for CTXN3 Gene

Transcripts for CTXN3 Gene

mRNA/cDNA for CTXN3 Gene

(4) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CTXN3 Gene

Cortexin 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTXN3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTXN3 Gene

No ASD Table

Relevant External Links for CTXN3 Gene

GeneLoc Exon Structure for
CTXN3
ECgene alternative splicing isoforms for
CTXN3

Expression for CTXN3 Gene

mRNA expression in normal human tissues for CTXN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTXN3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (11.8), Brain - Cortex (10.0), Kidney - Cortex (8.0), Brain - Anterior cingulate cortex (BA24) (7.2), and Brain - Substantia nigra (5.1).

SOURCE GeneReport for Unigene cluster for CTXN3 Gene Hs.66194

genes like me logo Genes that share expressions with CTXN3: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for CTXN3 Gene

Orthologs for CTXN3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CTXN3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CTXN3 35
  • 89.71 (n)
  • 92.59 (a)
CTXN3 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CTXN3 35
  • 89.71 (n)
  • 92.59 (a)
CTXN3 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ctxn3 35
  • 87.5 (n)
  • 93.75 (a)
Ctxn3 16
Ctxn3 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CTXN3 35
  • 97.94 (n)
  • 97.53 (a)
CTXN3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ctxn3 35
  • 88.75 (n)
  • 93.75 (a)
chicken
(Gallus gallus)
Aves LOC100859328 35
  • 76.13 (n)
  • 79.01 (a)
CTXN3 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CTXN3 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ctxn3 35
  • 69.66 (n)
  • 73.08 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100331302 35
  • 67.1 (n)
  • 71.43 (a)
CR396586.1 36
  • 46 (a)
OneToOne
Species with no ortholog for CTXN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTXN3 Gene

ENSEMBL:
Gene Tree for CTXN3 (if available)
TreeFam:
Gene Tree for CTXN3 (if available)

Paralogs for CTXN3 Gene

Paralogs for CTXN3 Gene

Selected SIMAP similar genes for CTXN3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CTXN3: view

Variants for CTXN3 Gene

Sequence variations from dbSNP and Humsavar for CTXN3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs45074 -- 127,657,557(+) CTAGT(C/G)CCCCT synonymous-codon, reference
rs248703 -- 127,658,882(+) GAAAA(A/G)CTTGT downstream-variant-500B
rs248704 -- 127,658,806(+) ACAGA(C/T)AAAAC downstream-variant-500B
rs248705 -- 127,658,689(+) GTATT(A/G)AGTGC downstream-variant-500B
rs248706 -- 127,658,266(+) TCTCC(C/T)AAAGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CTXN3 Gene

Variant ID Type Subtype PubMed ID
nsv830479 CNV Gain 17160897
nsv830480 CNV Loss 17160897

Relevant External Links for CTXN3 Gene

HapMap Linkage Disequilibrium report
CTXN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTXN3 Gene

Disorders for CTXN3 Gene

Relevant External Links for CTXN3

Genetic Association Database (GAD)
CTXN3
Human Genome Epidemiology (HuGE) Navigator
CTXN3

No disorders were found for CTXN3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CTXN3 Gene

Publications for CTXN3 Gene

  1. A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype. (PMID: 19023125) Potkin S.G. … Macciardi F. (Schizophr Bull 2009) 3 48
  2. Association of CTXN3-SLC12A2 polymorphisms and schizophrenia in a Thai population. (PMID: 22643131) Panichareon B. … Sukhumsirichart W. (Behav Brain Funct 2012) 3
  3. A genome-wide association meta-analysis of plasma AI^ peptides concentrations in the elderly. (PMID: 24535457) Chouraki V. … Lambert J.C. (Mol. Psychiatry 2014) 3
  4. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S. … Cupples L.A. (BMC Med. Genet. 2007) 48
  5. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PMID: 17903300) Fox C.S. … Atwood L.D. (BMC Med. Genet. 2007) 48

Products for CTXN3 Gene

Sources for CTXN3 Gene

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